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Beat Fierz, Ph.D. - Publications

Affiliations: 
École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland 
Area:
biological chemistry
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60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Franz P, Fierz B. Decoding chromatin ubiquitylation: a chemical biology perspective. Journal of Molecular Biology. 168442. PMID 38211893 DOI: 10.1016/j.jmb.2024.168442  0.365
2024 Moreno-Yruela C, Fierz B. Revealing chromatin-specific functions of histone deacylases. Biochemical Society Transactions. PMID 38189424 DOI: 10.1042/BST20230693  0.378
2023 Nagpal H, Ali-Ahmad A, Hirano Y, Cai W, Halic M, Fukagawa T, Sekulić N, Fierz B. CENP-A and CENP-B collaborate to create an open centromeric chromatin state. Nature Communications. 14: 8227. PMID 38086807 DOI: 10.1038/s41467-023-43739-5  0.366
2023 Michael AK, Stoos L, Crosby P, Eggers N, Nie XY, Makasheva K, Minnich M, Healy KL, Weiss J, Kempf G, Cavadini S, Kater L, Seebacher J, Vecchia L, Chakraborty D, ... ... Fierz B, et al. Cooperation between bHLH transcription factors and histones for DNA access. Nature. PMID 37407816 DOI: 10.1038/s41586-023-06282-3  0.342
2022 Bonnet J, Boichenko I, Kalb R, Le Jeune M, Maltseva S, Pieropan M, Finkl K, Fierz B, Müller J. PR-DUB preserves Polycomb repression by preventing excessive accumulation of H2Aub1, an antagonist of chromatin compaction. Genes & Development. 36: 1046-1061. PMID 36357125 DOI: 10.1101/gad.350014.122  0.312
2022 Guidotti N, Eördögh Á, Mivelaz M, Rivera-Fuentes P, Fierz B. Multivalent Peptide Ligands To Probe the Chromocenter Microenvironment in Living Cells. Acs Chemical Biology. PMID 35447032 DOI: 10.1021/acschembio.2c00203  0.357
2022 Heidarsson PO, Mercadante D, Sottini A, Nettels D, Borgia MB, Borgia A, Kilic S, Fierz B, Best RB, Schuler B. Release of linker histone from the nucleosome driven by polyelectrolyte competition with a disordered protein. Nature Chemistry. PMID 34992286 DOI: 10.1038/s41557-021-00839-3  0.319
2021 Balana AT, Mukherjee A, Nagpal H, Moon SP, Fierz B, Vasquez KM, Pratt MR. O-GlcNAcylation of High Mobility Group Box 1 (HMGB1) Alters Its DNA Binding and DNA Damage Processing Activities. Journal of the American Chemical Society. PMID 34546745 DOI: 10.1021/jacs.1c06192  0.53
2021 Stirpe A, Guidotti N, Northall SJ, Kilic S, Hainard A, Vadas O, Fierz B, Schalch T. SUV39 SET domains mediate crosstalk of heterochromatic histone marks. Elife. 10. PMID 34524082 DOI: 10.7554/eLife.62682  0.316
2021 Fierz B. Applying Peptide and Protein Synthesis to Study Post-translational Modifications in Epigenetics and Beyond. Chimia. 75: 484-488. PMID 34233809 DOI: 10.2533/chimia.2021.484  0.363
2021 Fierz B. Applying Peptide and Protein Synthesis to Study Post-translational Modifications in Epigenetics and Beyond. Chimia. 75: 484-488. PMID 34233809 DOI: 10.2533/chimia.2021.484  0.363
2020 Nagpal H, Fierz B. The elusive structure of centro-chromatin: molecular order or dynamic heterogenetity? Journal of Molecular Biology. PMID 33065112 DOI: 10.1016/j.jmb.2020.10.010  0.336
2020 Pathare GR, Decout A, Glück S, Cavadini S, Makasheva K, Hovius R, Kempf G, Weiss J, Kozicka Z, Guey B, Melenec P, Fierz B, Thomä NH, Ablasser A. Structural mechanism of cGAS inhibition by the nucleosome. Nature. PMID 32911482 DOI: 10.1038/S41586-020-2750-6  0.396
2020 Dhall A, Shelton PMM, Delachat AM, Leonen CJA, Fierz B, Chatterjee C. Nucleosome binding by the lysine specific demethylase 1 (LSD1) enzyme enables histone H3 demethylation. Biochemistry. PMID 32567837 DOI: 10.1021/Acs.Biochem.0C00412  0.635
2020 Guidotti N, Fierz B. Semisynthesis and Reconstitution of Nucleosomes Carrying Asymmetric Histone Modifications. Methods in Molecular Biology (Clifton, N.J.). 2133: 263-291. PMID 32144672 DOI: 10.1007/978-1-0716-0434-2_13  0.493
2020 Mivelaz M, Fierz B. Observing protein interaction dynamics to chemically defined chromatin fibers by colocalization single-molecule fluorescence microscopy. Methods (San Diego, Calif.). PMID 32004546 DOI: 10.1016/J.Ymeth.2020.01.018  0.509
2019 Mivelaz M, Cao AM, Kubik S, Zencir S, Hovius R, Boichenko I, Stachowicz AM, Kurat CF, Shore D, Fierz B. Chromatin Fiber Invasion and Nucleosome Displacement by the Rap1 Transcription Factor. Molecular Cell. PMID 31761495 DOI: 10.1016/J.Molcel.2019.10.025  0.461
2019 Fierz B, Poirier MG. Biophysics of Chromatin Dynamics. Annual Review of Biophysics. PMID 30883217 DOI: 10.1146/Annurev-Biophys-070317-032847  0.468
2019 Fierz B. Revealing chromatin organization in metaphase chromosomes. The Embo Journal. PMID 30833290 DOI: 10.15252/Embj.2019101699  0.338
2019 Boichenko I, Fierz B. Chemical and biophysical methods to explore dynamic mechanisms of chromatin silencing. Current Opinion in Chemical Biology. 51: 1-10. PMID 30825740 DOI: 10.1016/J.Cbpa.2019.01.022  0.49
2019 Callegari A, Sieben C, Benke A, Suter DM, Fierz B, Mazza D, Manley S. Single-molecule dynamics and genome-wide transcriptomics reveal that NF-kB (p65)-DNA binding times can be decoupled from transcriptional activation. Plos Genetics. 15: e1007891. PMID 30653501 DOI: 10.1371/Journal.Pgen.1007891  0.338
2019 Guidotti N, Lechner CC, Bachmann AL, Fierz B. A modular ligation strategy for asymmetric bivalent nucleosomes trimethylated at K36 and K27. Chembiochem : a European Journal of Chemical Biology. PMID 30615245 DOI: 10.1002/Cbic.201800744  0.439
2019 Tessier R, Ceballos J, Guidotti N, Simonet-Davin R, Fierz B, Waser J. “Doubly Orthogonal” Labeling of Peptides and Proteins Chem. 5: 2243-2263. DOI: 10.1016/J.Chempr.2019.06.022  0.34
2019 Cao A, Mivelaz M, Boichenko I, Bryan L, Kubik S, Shore D, Fierz B. Chromatin Remodeling Induced by the Invasion of Yeast Pioneer Transcription Factor Rap1 Revealed by Single-Molecule FRET Biophysical Journal. 116: 39a-40a. DOI: 10.1016/J.Bpj.2018.11.258  0.352
2018 Kilic S, Boichenko I, Lechner CC, Fierz B. A bi-terminal protein ligation strategy to probe chromatin structure during DNA damage. Chemical Science. 9: 3704-3709. PMID 29780501 DOI: 10.1039/C8Sc00681D  0.42
2018 Kilic S, Felekyan S, Doroshenko O, Boichenko I, Dimura M, Vardanyan H, Bryan LC, Arya G, Seidel CAM, Fierz B. Single-molecule FRET reveals multiscale chromatin dynamics modulated by HP1α. Nature Communications. 9: 235. PMID 29339721 DOI: 10.1038/S41467-017-02619-5  0.49
2017 Delachat AM, Guidotti N, Bachmann AL, Meireles-Filho ACA, Pick H, Lechner CC, Deluz C, Deplancke B, Suter DM, Fierz B. Engineered Multivalent Sensors to Detect Coexisting Histone Modifications in Living Stem Cells. Cell Chemical Biology. PMID 29174541 DOI: 10.1016/J.Chembiol.2017.10.008  0.443
2017 Choi J, Bachmann AL, Tauscher K, Benda C, Fierz B, Müller J. DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation. Nature Structural & Molecular Biology. PMID 29058710 DOI: 10.1038/Nsmb.3488  0.431
2017 Bryan LC, Weilandt DR, Bachmann AL, Kilic S, Lechner CC, Odermatt PD, Fantner GE, Georgeon S, Hantschel O, Hatzimanikatis V, Fierz B. Single-molecule kinetic analysis of HP1-chromatin binding reveals a dynamic network of histone modification and DNA interactions. Nucleic Acids Research. PMID 28985346 DOI: 10.1093/Nar/Gkx697  0.482
2017 Guidotti N, Lechner CC, Fierz B. Controlling the supramolecular assembly of nucleosomes asymmetrically modified on H4. Chemical Communications (Cambridge, England). PMID 28862273 DOI: 10.1039/C7Cc06180C  0.382
2017 Cuvier O, Fierz B. Dynamic chromatin technologies: from individual molecules to epigenomic regulation in cells. Nature Reviews. Genetics. PMID 28529337 DOI: 10.1038/Nrg.2017.28  0.401
2016 Müller MM, Fierz B, Bittova L, Liszczak G, Muir TW. A two-state activation mechanism controls the histone methyltransferase Suv39h1. Nature Chemical Biology. PMID 26807716 DOI: 10.1038/Nchembio.2008  0.64
2016 Lechner CC, Agashe ND, Fierz B. Traceless Synthesis of Asymmetrically Modified Bivalent Nucleosomes. Angewandte Chemie (International Ed. in English). PMID 26806951 DOI: 10.1002/Anie.201510996  0.466
2015 Bryan LC, Bachmann AL, Fierz B. Molecular and Chemical Mechanism in Epigenetics - Swiss Summer School 2015 July 12-17, 2015, Hotel Kurhaus, Arolla, Switzerland. Chimia. 69: 624-6. PMID 26598408 DOI: 10.2533/Chimia.2015.624  0.317
2015 Fierz B. Dynamic chromatin regulation from a single molecule perspective. Acs Chemical Biology. PMID 26565113 DOI: 10.1021/Acschembio.5B00832  0.425
2015 Kilic S, Bachmann AL, Bryan LC, Fierz B. Multivalency governs HP1α association dynamics with the silent chromatin state. Nature Communications. 6: 7313. PMID 26084584 DOI: 10.1038/Ncomms8313  0.508
2014 Dhall A, Wei S, Fierz B, Woodcock CL, Lee TH, Chatterjee C. Sumoylated human histone H4 prevents chromatin compaction by inhibiting long-range internucleosomal interactions. The Journal of Biological Chemistry. 289: 33827-37. PMID 25294883 DOI: 10.1074/Jbc.M114.591644  0.657
2014 Nguyen UT, Bittova L, Müller MM, Fierz B, David Y, Houck-Loomis B, Feng V, Dann GP, Muir TW. Accelerated chromatin biochemistry using DNA-barcoded nucleosome libraries. Nature Methods. 11: 834-40. PMID 24997861 DOI: 10.1038/Nmeth.3022  0.76
2014 Pick H, Kilic S, Fierz B. Engineering chromatin states: chemical and synthetic biology approaches to investigate histone modification function. Biochimica Et Biophysica Acta. 1839: 644-56. PMID 24768924 DOI: 10.1016/J.Bbagrm.2014.04.016  0.483
2014 Fierz B. Synthetic chromatin approaches to probe the writing and erasing of histone modifications. Chemmedchem. 9: 495-504. PMID 24497444 DOI: 10.1002/Cmdc.201300487  0.481
2014 Fierz B. Chromatin as a Dynamic Platform for Protein-Protein Interactions Biophysical Journal. 106: 77a. DOI: 10.1016/J.Bpj.2013.11.502  0.351
2013 Kim DH, Tang Z, Shimada M, Fierz B, Houck-Loomis B, Bar-Dagen M, Lee S, Lee SK, Muir TW, Roeder RG, Lee JW. Histone H3K27 trimethylation inhibits H3 binding and function of SET1-like H3K4 methyltransferase complexes. Molecular and Cellular Biology. 33: 4936-46. PMID 24126056 DOI: 10.1128/Mcb.00601-13  0.596
2013 Neumaier S, Reiner A, Büttner M, Fierz B, Kiefhaber T. Testing the diffusing boundary model for the helix-coil transition in peptides. Proceedings of the National Academy of Sciences of the United States of America. 110: 12905-10. PMID 23878243 DOI: 10.1073/Pnas.1303515110  0.674
2012 Fierz B, Kilic S, Hieb AR, Luger K, Muir TW. Stability of nucleosomes containing homogenously ubiquitylated H2A and H2B prepared using semisynthesis. Journal of the American Chemical Society. 134: 19548-51. PMID 23163596 DOI: 10.1021/Ja308908P  0.641
2012 Whitcomb SJ, Fierz B, McGinty RK, Holt M, Ito T, Muir TW, Allis CD. Histone monoubiquitylation position determines specificity and direction of enzymatic cross-talk with histone methyltransferases Dot1L and PRC2. The Journal of Biological Chemistry. 287: 23718-25. PMID 22619169 DOI: 10.1074/Jbc.M112.361824  0.715
2012 Fierz B, Muir TW. Chromatin as an expansive canvas for chemical biology. Nature Chemical Biology. 8: 417-27. PMID 22510649 DOI: 10.1038/Nchembio.938  0.594
2011 Fierz B, Chatterjee C, McGinty RK, Bar-Dagan M, Raleigh DP, Muir TW. Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction. Nature Chemical Biology. 7: 113-9. PMID 21196936 DOI: 10.1038/Nchembio.501  0.722
2011 Reiner A, Fierz B, Kiefhaber T. Conformational dynamics in peptides and proteins studied by triplet-triplet energy transfer Methods in Protein Biochemistry. 73-94. DOI: 10.1515/9783110252361  0.66
2011 Fierz B, Chatterjee C, McGinty RK, Bar-Dagan M, Raleigh DP, Muir TW. Discrete Mechanisms Govern the Modulation of Chromatin Structure by Ubiquitylation and Acetylation Biophysical Journal. 100: 68a. DOI: 10.1016/J.Bpj.2010.12.570  0.714
2010 Chatterjee C, McGinty RK, Fierz B, Muir TW. Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation. Nature Chemical Biology. 6: 267-9. PMID 20208522 DOI: 10.1038/Nchembio.315  0.683
2009 Fierz B, Reiner A, Kiefhaber T. Local conformational dynamics in alpha-helices measured by fast triplet transfer. Proceedings of the National Academy of Sciences of the United States of America. 106: 1057-62. PMID 19131517 DOI: 10.1073/Pnas.0808581106  0.68
2008 Fierz B, Kiefhaber T. Dynamics of Unfolded Polypeptide Chains Protein Folding Handbook. 2: 809-855. DOI: 10.1002/9783527619498.ch22  0.547
2007 Fierz B, Satzger H, Root C, Gilch P, Zinth W, Kiefhaber T. Loop formation in unfolded polypeptide chains on the picoseconds to microseconds time scale. Proceedings of the National Academy of Sciences of the United States of America. 104: 2163-8. PMID 17284588 DOI: 10.1073/Pnas.0611087104  0.616
2007 Fierz B, Kiefhaber T. End-to-end vs interior loop formation kinetics in unfolded polypeptide chains. Journal of the American Chemical Society. 129: 672-9. PMID 17227031 DOI: 10.1021/Ja0666396  0.587
2007 Fierz B, Joder K, Krieger F, Kiefhaber T. Using triplet-triplet energy transfer to measure conformational dynamics in polypeptide chains. Methods in Molecular Biology (Clifton, N.J.). 350: 169-87. PMID 16957323 DOI: 10.1385/1-59745-189-4:169  0.605
2006 Heinz B, Schmidt B, Root C, Satzger H, Milota F, Fierz B, Kiefhaber T, Zinth W, Gilch P. On the unusual fluorescence properties of xanthone in water. Physical Chemistry Chemical Physics : Pccp. 8: 3432-9. PMID 16855722 DOI: 10.1039/B603560D  0.566
2006 Heinz B, Schmidt B, Root C, Satzger H, Milota F, Fierz B, Kiefhaber T, Zinth W, Gilch P. Slow fluorescence and fast intersystem crossing - the xanthone anomaly Optics Infobase Conference Papers.  0.52
2004 Satzger H, Schmidt B, Root C, Zinth W, Fierz B, Krieger F, Kiefhaber T, Gilch P. Ultrafast quenching of the xanthone triplet by energy transfer: New insight into the intersystem crossing kinetics Journal of Physical Chemistry A. 108: 10072-10079. DOI: 10.1021/Jp047583+  0.598
2004 Krieger F, Fierz B, Axthelm F, Joder K, Meyer D, Kiefhaber T. Intrachain diffusion in a protein loop fragment from carp parvalbumin Chemical Physics. 307: 209-215. DOI: 10.1016/J.Chemphys.2004.05.036  0.613
2003 Krieger F, Fierz B, Bieri O, Drewello M, Kiefhaber T. Dynamics of unfolded polypeptide chains as model for the earliest steps in protein folding. Journal of Molecular Biology. 332: 265-74. PMID 12946363 DOI: 10.1016/S0022-2836(03)00892-1  0.617
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