Andre Nussenzweig, Ph.D. - Publications

Affiliations: 
Center for Cancer Research National Cancer Institute, NIH, Bethesda, Bethesda, MD, United States 
Area:
genomic Instability, DNA damage/repair, recombination/replication
Website:
https://ccr.cancer.gov/Laboratory-of-Genome-Integrity/andre-nussenzweig

113 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Callen E, Zong D, Wu W, Wong N, Stanlie A, Ishikawa M, Pavani R, Dumitrache LC, Byrum AK, Mendez-Dorantes C, Martinez P, Canela A, Maman Y, Day A, Kruhlak MJ, ... ... Nussenzweig A, et al. 53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination. Molecular Cell. PMID 31653568 DOI: 10.1016/j.molcel.2019.09.024  0.52
2019 Canela A, Maman Y, Huang SN, Wutz G, Tang W, Zagnoli-Vieira G, Callen E, Wong N, Day A, Peters JM, Caldecott KW, Pommier Y, Nussenzweig A. Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity. Molecular Cell. PMID 31202577 DOI: 10.1016/j.molcel.2019.04.030  0.32
2019 Zong D, Adam S, Wang Y, Sasanuma H, Callén E, Murga M, Day A, Kruhlak MJ, Wong N, Munro M, Ray Chaudhuri A, Karim B, Xia B, Takeda S, Johnson N, ... ... Nussenzweig A, et al. BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation. Molecular Cell. PMID 30704900 DOI: 10.1016/j.molcel.2018.12.010  0.52
2018 Tubbs A, Sridharan S, van Wietmarschen N, Maman Y, Callen E, Stanlie A, Wu W, Wu X, Day A, Wong N, Yin M, Canela A, Fu H, Redon C, Pruitt SC, ... ... Nussenzweig A, et al. Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse. Cell. PMID 30078706 DOI: 10.1016/j.cell.2018.07.011  0.32
2018 Di Siena S, Campolo F, Gimmelli R, Di Pietro C, Marazziti D, Dolci S, Lenzi A, Nussenzweig A, Pellegrini M. Atm reactivation reverses ataxia telangiectasia phenotypes in vivo. Cell Death & Disease. 9: 314. PMID 29472706 DOI: 10.1038/s41419-018-0357-8  0.4
2017 Canela A, Maman Y, Jung S, Wong N, Callen E, Day A, Kieffer-Kwon KR, Pekowska A, Zhang H, Rao SSP, Huang SC, Mckinnon PJ, Aplan PD, Pommier Y, Aiden EL, ... ... Nussenzweig A, et al. Genome Organization Drives Chromosome Fragility. Cell. PMID 28735753 DOI: 10.1016/j.cell.2017.06.034  0.52
2016 Chaudhuri AR, Callen E, Ding X, Gogola E, Duarte AA, Lee JE, Wong N, Lafarga V, Calvo JA, Panzarino NJ, John S, Day A, Crespo AV, Shen B, Starnes LM, ... ... Nussenzweig A, et al. Erratum: Replication fork stability confers chemoresistance in BRCA-deficient cells. Nature. PMID 27680696 DOI: 10.1038/nature19826  0.88
2016 Li M, Cole F, Patel DS, Misenko SM, Her J, Malhowski A, Alhamza A, Zheng H, Baer R, Ludwig T, Jasin M, Nussenzweig A, Serrano L, Bunting SF. 53BP1 ablation rescues genomic instability in mice expressing 'RING-less' BRCA1. Embo Reports. PMID 27670884 DOI: 10.15252/embr.201642497  0.32
2016 Morgado-Palacin I, Day A, Murga M, Lafarga V, Anton ME, Tubbs A, Chen HT, Ergan A, Anderson R, Bhandoola A, Pike KG, Barlaam B, Cadogan E, Wang X, Pierce AJ, ... ... Nussenzweig A, et al. Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML. Science Signaling. 9: ra91. PMID 27625305 DOI: 10.1126/scisignal.aad8243  0.88
2016 Nieto-Soler M, Morgado-Palacin I, Lafarga V, Lecona E, Murga M, Callen E, Azorin D, Alonso J, Lopez-Contreras AJ, Nussenzweig A, Fernandez-Capetillo O. Efficacy of ATR inhibitors as single agents in Ewing sarcoma. Oncotarget. 7: 58759-58767. PMID 27577084 DOI: 10.18632/oncotarget.11643  0.88
2016 Ding X, Chaudhuri AR, Callen E, Pang Y, Biswas K, Klarmann KD, Martin BK, Burkett S, Cleveland L, Stauffer S, Sullivan T, Dewan A, Marks H, Tubbs AT, Wong N, ... ... Nussenzweig A, et al. Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies. Nature Communications. 7: 12425. PMID 27498558 DOI: 10.1038/ncomms12425  0.52
2016 Canela A, Sridharan S, Sciascia N, Tubbs A, Meltzer P, Sleckman BP, Nussenzweig A. DNA Breaks and End Resection Measured Genome-wide by End Sequencing. Molecular Cell. PMID 27477910 DOI: 10.1016/j.molcel.2016.06.034  0.32
2016 Ray Chaudhuri A, Callen E, Ding X, Gogola E, Duarte AA, Lee JE, Wong N, Lafarga V, Calvo JA, Panzarino NJ, John S, Day A, Crespo AV, Shen B, Starnes LM, ... ... Nussenzweig A, et al. Replication fork stability confers chemoresistance in BRCA-deficient cells. Nature. 535: 382-7. PMID 27443740 DOI: 10.1038/nature18325  0.52
2016 Starnes LM, Su D, Pikkupeura LM, Weinert BT, Santos MA, Mund A, Soria R, Cho YW, Pozdnyakova I, Kubec Højfeldt M, Vala A, Yang W, López-Méndez B, Lee JE, Peng W, ... ... Nussenzweig A, et al. A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. Genes & Development. PMID 26744420 DOI: 10.1101/gad.268797.115  0.52
2015 Cloutier JM, Mahadevaiah SK, ElInati E, Nussenzweig A, Tóth A, Turner JM. Histone H2AFX Links Meiotic Chromosome Asynapsis to Prophase I Oocyte Loss in Mammals. Plos Genetics. 11: e1005462. PMID 26509888 DOI: 10.1371/journal.pgen.1005462  0.52
2015 Ortega-Molina A, Boss IW, Canela A, Pan H, Jiang Y, Zhao C, Jiang M, Hu D, Agirre X, Niesvizky I, Lee JE, Chen HT, Ennishi D, Scott DW, Mottok A, ... ... Nussenzweig A, et al. The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development. Nature Medicine. PMID 26366710 DOI: 10.1038/nm.3943  0.32
2015 Robbiani DF, Deroubaix S, Feldhahn N, Oliveira TY, Callen E, Wang Q, Jankovic M, Silva IT, Rommel PC, Bosque D, Eisenreich T, Nussenzweig A, Nussenzweig MC. Plasmodium Infection Promotes Genomic Instability and AID-Dependent B Cell Lymphoma. Cell. 162: 727-37. PMID 26276629 DOI: 10.1016/j.cell.2015.07.019  0.52
2015 Lopez-Contreras AJ, Specks J, Barlow JH, Ambrogio C, Desler C, Vikingsson S, Rodrigo-Perez S, Green H, Rasmussen LJ, Murga M, Nussenzweig A, Fernandez-Capetillo O. Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice. Genes & Development. 29: 690-5. PMID 25838540 DOI: 10.1101/gad.256958.114  0.52
2014 Santos MA, Faryabi RB, Ergen AV, Day AM, Malhowski A, Canela A, Onozawa M, Lee JE, Callen E, Gutierrez-Martinez P, Chen HT, Wong N, Finkel N, Deshpande A, Sharrow S, ... ... Nussenzweig A, et al. DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier. Nature. 514: 107-11. PMID 25079327 DOI: 10.1038/nature13483  0.52
2014 Polato F, Callen E, Wong N, Faryabi R, Bunting S, Chen HT, Kozak M, Kruhlak MJ, Reczek CR, Lee WH, Ludwig T, Baer R, Feigenbaum L, Jackson S, Nussenzweig A. CtIP-mediated resection is essential for viability and can operate independently of BRCA1. The Journal of Experimental Medicine. 211: 1027-36. PMID 24842372 DOI: 10.1084/jem.20131939  0.52
2013 Fernandez-Capetillo O, Nussenzweig A. Naked replication forks break apRPArt. Cell. 155: 979-80. PMID 24267882 DOI: 10.1016/j.cell.2013.10.049  0.88
2013 Lee BS, Gapud EJ, Zhang S, Dorsett Y, Bredemeyer A, George R, Callen E, Daniel JA, Osipovich O, Oltz EM, Bassing CH, Nussenzweig A, Lees-Miller S, Hammel M, Chen BP, et al. Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination. Molecular and Cellular Biology. 33: 3568-79. PMID 23836881 DOI: 10.1128/MCB.00308-13  0.52
2013 Bunting SF, Nussenzweig A. End-joining, translocations and cancer Nature Reviews Cancer. 13: 443-454. PMID 23760025 DOI: 10.1038/nrc3537  0.52
2013 Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen HT, Faryabi RB, Polato F, Santos M, Starnes LM, Wesemann DR, Lee JE, Tubbs A, Sleckman BP, Daniel JA, ... ... Nussenzweig A, et al. 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell. 153: 1266-80. PMID 23727112 DOI: 10.1016/j.cell.2013.05.023  0.52
2013 Daniel JA, Nussenzweig A. The AID-induced DNA damage response in chromatin Molecular Cell. 50: 309-321. PMID 23664375 DOI: 10.1016/j.molcel.2013.04.017  0.32
2013 Bowman-Colin C, Xia B, Bunting S, Klijn C, Drost R, Bouwman P, Fineman L, Chen X, Culhane AC, Cai H, Rodig SJ, Bronson RT, Jonkers J, Nussenzweig A, Kanellopoulou C, et al. Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 110: 8632-7. PMID 23657012 DOI: 10.1073/pnas.1305362110  0.52
2013 Barlow JH, Faryabi RB, Callén E, Wong N, Malhowski A, Chen HT, Gutierrez-Cruz G, Sun HW, McKinnon P, Wright G, Casellas R, Robbiani DF, Staudt L, Fernandez-Capetillo O, Nussenzweig A. Identification of early replicating fragile sites that contribute to genome instability. Cell. 152: 620-32. PMID 23352430 DOI: 10.1016/j.cell.2013.01.006  0.88
2013 Di Virgilio M, Callen E, Yamane A, Zhang W, Jankovic M, Gitlin AD, Feldhahn N, Resch W, Oliveira TY, Chait BT, Nussenzweig A, Casellas R, Robbiani DF, Nussenzweig MC. Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching. Science (New York, N.Y.). 339: 711-5. PMID 23306439 DOI: 10.1126/science.1230624  0.52
2013 Yamane A, Robbiani DF, Resch W, Bothmer A, Nakahashi H, Oliveira T, Rommel PC, Brown EJ, Nussenzweig A, Nussenzweig MC, Casellas R. RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycle. Cell Reports. 3: 138-47. PMID 23291097 DOI: 10.1016/j.celrep.2012.12.006  0.52
2013 Bothmer A, Rommel PC, Gazumyan A, Polato F, Reczek CR, Muellenbeck MF, Schaetzlein S, Edelmann W, Chen PL, Brosh RM, Casellas R, Ludwig T, Baer R, Nussenzweig A, Nussenzweig MC, et al. Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching. The Journal of Experimental Medicine. 210: 115-23. PMID 23254285 DOI: 10.1084/jem.20121975  0.52
2012 Sin HS, Barski A, Zhang F, Kartashov AV, Nussenzweig A, Chen J, Andreassen PR, Namekawa SH. RNF8 regulates active epigenetic modifications and escape gene activation from inactive sex chromosomes in post-meiotic spermatids. Genes & Development. 26: 2737-48. PMID 23249736 DOI: 10.1101/gad.202713.112  0.52
2012 Callen E, Faryabi RB, Luckey M, Hao B, Daniel JA, Yang W, Sun HW, Dressler G, Peng W, Chi H, Ge K, Krangel MS, Park JH, Nussenzweig A. The DNA Damage- and Transcription-Associated Protein Paxip1 Controls Thymocyte Development and Emigration Immunity. 37: 971-985. PMID 23159437 DOI: 10.1016/j.immuni.2012.10.007  0.32
2012 Feldhahn N, Ferretti E, Robbiani DF, Callen E, Deroubaix S, Selleri L, Nussenzweig A, Nussenzweig MC. The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo. The Embo Journal. 31: 4045-56. PMID 22940690 DOI: 10.1038/emboj.2012.247  0.52
2012 Daniel JA, Pellegrini M, Lee BS, Guo Z, Filsuf D, Belkina NV, You Z, Paull TT, Sleckman BP, Feigenbaum L, Nussenzweig A. Loss of ATM kinase activity leads to embryonic lethality in mice Journal of Cell Biology. 198: 295-304. PMID 22869595 DOI: 10.1083/jcb.201204035  0.52
2012 Daniel JA, Nussenzweig A. Roles for histone H3K4 methyltransferase activities during immunoglobulin class-switch recombination Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms. 1819: 733-738. PMID 22710321 DOI: 10.1016/j.bbagrm.2012.01.019  0.32
2012 Bunting SF, Callén E, Kozak ML, Kim JM, Wong N, López-Contreras AJ, Ludwig T, Baer R, Faryabi RB, Malhowski A, Chen HT, Fernandez-Capetillo O, D'Andrea A, Nussenzweig A. BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair. Molecular Cell. 46: 125-35. PMID 22445484 DOI: 10.1016/j.molcel.2012.02.015  0.52
2012 Hakim O, Resch W, Yamane A, Klein I, Kieffer-Kwon KR, Jankovic M, Oliveira T, Bothmer A, Voss TC, Ansarah-Sobrinho C, Mathe E, Liang G, Cobell J, Nakahashi H, Robbiani DF, ... Nussenzweig A, et al. DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes. Nature. 484: 69-74. PMID 22314321 DOI: 10.1038/nature10909  0.52
2011 Klein IA, Resch W, Jankovic M, Oliveira T, Yamane A, Nakahashi H, Di Virgilio M, Bothmer A, Nussenzweig A, Robbiani DF, Casellas R, Nussenzweig MC. Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes. Cell. 147: 95-106. PMID 21962510 DOI: 10.1016/j.cell.2011.07.048  0.52
2011 Bothmer A, Robbiani DF, Di Virgilio M, Bunting SF, Klein IA, Feldhahn N, Barlow J, Chen HT, Bosque D, Callen E, Nussenzweig A, Nussenzweig MC. Regulation of DNA End Joining, Resection, and Immunoglobulin Class Switch Recombination by 53BP1 Molecular Cell. 42: 319-329. PMID 21549309 DOI: 10.1016/j.molcel.2011.03.019  0.52
2011 Zhang S, Yajima H, Huynh H, Zheng J, Callen E, Chen HT, Wong N, Bunting S, Lin YF, Li M, Lee KJ, Story M, Gapud E, Sleckman BP, Nussenzweig A, et al. Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair. The Journal of Cell Biology. 193: 295-305. PMID 21482716 DOI: 10.1083/jcb.201009074  0.52
2011 Fernando RN, Eleuteri B, Abdelhady S, Nussenzweig A, Andäng M, Ernfors P. Cell cycle restriction by histone H2AX limits proliferation of adult neural stem cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 5837-42. PMID 21436033 DOI: 10.1073/pnas.1014993108  0.52
2011 Gapud EJ, Dorsett Y, Yin B, Callen E, Bredemeyer A, Mahowald GK, Omi KQ, Walker LM, Bednarski JJ, McKinnon PJ, Bassing CH, Nussenzweig A, Sleckman BP. Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation. Proceedings of the National Academy of Sciences of the United States of America. 108: 2022-7. PMID 21245316 DOI: 10.1073/pnas.1013295108  0.52
2011 Pellegrini M, Claps G, Orlova VV, Barrios F, Dolci S, Geremia R, Rossi P, Rossi G, Arnold B, Chavakis T, Feigenbaum L, Sharan SK, Nussenzweig A. Targeted JAM-C deletion in germ cells by Spo11-controlled Cre recombinase. Journal of Cell Science. 124: 91-9. PMID 21147852 DOI: 10.1242/jcs.072959  0.4
2010 Daniel JA, Santos MA, Wang Z, Zang C, Schwab KR, Jankovic M, Filsuf D, Chen HT, Gazumyan A, Yamane A, Cho YW, Sun HW, Ge K, Peng W, Nussenzweig MC, ... ... Nussenzweig A, et al. PTIP promotes chromatin changes critical for immunoglobulin class switch recombination Science. 329: 917-923. PMID 20671152 DOI: 10.1126/science.1187942  0.52
2010 Santos MA, Huen MS, Jankovic M, Chen HT, López-Contreras AJ, Klein IA, Wong N, Barbancho JL, Fernandez-Capetillo O, Nussenzweig MC, Chen J, Nussenzweig A. Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8. The Journal of Experimental Medicine. 207: 973-81. PMID 20385748 DOI: 10.1084/jem.20092308  0.88
2010 Nussenzweig A, Nussenzweig MC. Origin of chromosomal translocations in lymphoid cancer. Cell. 141: 27-38. PMID 20371343 DOI: 10.1016/j.cell.2010.03.016  0.52
2010 Bothmer A, Robbiani DF, Feldhahn N, Gazumyan A, Nussenzweig A, Nussenzweig MC. 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. The Journal of Experimental Medicine. 207: 855-65. PMID 20368578 DOI: 10.1084/jem.20100244  0.52
2010 Bunting SF, Callén E, Wong N, Chen HT, Polato F, Gunn A, Bothmer A, Feldhahn N, Fernandez-Capetillo O, Cao L, Xu X, Deng CX, Finkel T, Nussenzweig M, Stark JM, ... Nussenzweig A, et al. 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell. 141: 243-54. PMID 20362325 DOI: 10.1016/j.cell.2010.03.012  0.52
2010 Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, ... ... Nussenzweig A, et al. Impact papers on aging in 2009. Aging. 2: 111-21. PMID 20351400 DOI: v2/n3/full/100132.html  0.52
2010 Boboila C, Yan C, Wesemann DR, Jankovic M, Wang JH, Manis J, Nussenzweig A, Nussenzweig M, Alt FW. Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4. The Journal of Experimental Medicine. 207: 417-27. PMID 20142431 DOI: 10.1084/jem.20092449  0.52
2010 Boboila C, Jankovic M, Yan CT, Wang JH, Wesemann DR, Zhang T, Fazeli A, Feldman L, Nussenzweig A, Nussenzweig M, Alt FW. Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proceedings of the National Academy of Sciences of the United States of America. 107: 3034-9. PMID 20133803 DOI: 10.1073/pnas.0915067107  0.52
2010 Jankovic M, Robbiani DF, Dorsett Y, Eisenreich T, Xu Y, Tarakhovsky A, Nussenzweig A, Nussenzweig MC. Role of the translocation partner in protection against AID-dependent chromosomal translocations. Proceedings of the National Academy of Sciences of the United States of America. 107: 187-92. PMID 19966290 DOI: 10.1073/pnas.0908946107  0.52
2009 Robbiani DF, Bunting S, Feldhahn N, Bothmer A, Camps J, Deroubaix S, McBride KM, Klein IA, Stone G, Eisenreich TR, Ried T, Nussenzweig A, Nussenzweig MC. AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Molecular Cell. 36: 631-41. PMID 19941823 DOI: 10.1016/j.molcel.2009.11.007  0.52
2009 Kawauchi S, Calof AL, Santos R, Lopez-Burks ME, Young CM, Hoang MP, Chua A, Lao T, Lechner MS, Daniel JA, Nussenzweig A, Kitzes L, Yokomori K, Hallgrimsson B, Lander AD. Multiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange Syndrome. Plos Genetics. 5: e1000650. PMID 19763162 DOI: 10.1371/journal.pgen.1000650  0.52
2009 Cao L, Xu X, Bunting SF, Liu J, Wang RH, Cao LL, Wu JJ, Peng TN, Chen J, Nussenzweig A, Deng CX, Finkel T. A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Molecular Cell. 35: 534-41. PMID 19716796 DOI: 10.1016/j.molcel.2009.06.037  0.52
2009 Murga M, Bunting S, Montaña MF, Soria R, Mulero F, Cañamero M, Lee Y, McKinnon PJ, Nussenzweig A, Fernandez-Capetillo O. A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nature Genetics. 41: 891-8. PMID 19620979 DOI: 10.1038/ng.420  0.52
2009 Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW. Mechanisms promoting translocations in editing and switching peripheral B cells. Nature. 460: 231-6. PMID 19587764 DOI: 10.1038/nature08159  0.52
2009 Callén E, Bunting S, Huang CY, Difilippantonio MJ, Wong N, Khor B, Mahowald G, Kruhlak MJ, Ried T, Sleckman BP, Nussenzweig A. Chimeric IgH-TCRalpha/delta translocations in T lymphocytes mediated by RAG. Cell Cycle (Georgetown, Tex.). 8: 2408-12. PMID 19556863  0.52
2009 Callén E, Jankovic M, Wong N, Zha S, Chen HT, Difilippantonio S, Di Virgilio M, Heidkamp G, Alt FW, Nussenzweig A, Nussenzweig M. Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Molecular Cell. 34: 285-97. PMID 19450527 DOI: 10.1016/j.molcel.2009.04.025  0.52
2009 Kruhlak MJ, Celeste A, Nussenzweig A. Monitoring DNA breaks in optically highlighted chromatin in living cells by laser scanning confocal microscopy. Methods in Molecular Biology (Clifton, N.J.). 523: 125-40. PMID 19381917 DOI: 10.1007/978-1-59745-190-1_9  0.52
2009 Economopoulou M, Langer HF, Celeste A, Orlova VV, Choi EY, Ma M, Vassilopoulos A, Callen E, Deng C, Bassing CH, Boehm M, Nussenzweig A, Chavakis T. Histone H2AX is integral to hypoxia-driven neovascularization. Nature Medicine. 15: 553-8. PMID 19377486 DOI: 10.1038/nm.1947  0.52
2008 Robbiani DF, Bothmer A, Callen E, Reina-San-Martin B, Dorsett Y, Difilippantonio S, Bolland DJ, Chen HT, Corcoran AE, Nussenzweig A, Nussenzweig MC. AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations. Cell. 135: 1028-38. PMID 19070574 DOI: 10.1016/j.cell.2008.09.062  0.92
2008 Daniel JA, Pellegrini M, Lee JH, Paull TT, Feigenbaum L, Nussenzweig A. Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo Journal of Cell Biology. 183: 777-783. PMID 19047460 DOI: 10.1083/jcb.200805154  0.52
2008 Difilippantonio S, Gapud E, Wong N, Huang CY, Mahowald G, Chen HT, Kruhlak MJ, Callen E, Livak F, Nussenzweig MC, Sleckman BP, Nussenzweig A. 53BP1 facilitates long-range DNA end-joining during V(D)J recombination. Nature. 456: 529-33. PMID 18931658 DOI: 10.1038/nature07476  0.92
2008 Fernandez-Capetillo O, Nussenzweig A. ATM breaks into heterochromatin. Molecular Cell. 31: 303-4. PMID 18691960 DOI: 10.1016/j.molcel.2008.07.004  0.88
2008 Takizawa M, Tolarová H, Li Z, Dubois W, Lim S, Callen E, Franco S, Mosaico M, Feigenbaum L, Alt FW, Nussenzweig A, Potter M, Casellas R. AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development. The Journal of Experimental Medicine. 205: 1949-57. PMID 18678733 DOI: 10.1084/jem.20081007  0.52
2008 Schotta G, Sengupta R, Kubicek S, Malin S, Kauer M, Callén E, Celeste A, Pagani M, Opravil S, De La Rosa-Velazquez IA, Espejo A, Bedford MT, Nussenzweig A, Busslinger M, Jenuwein T. A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes & Development. 22: 2048-61. PMID 18676810 DOI: 10.1101/gad.476008  0.52
2007 Nussenzweig A, Nussenzweig MC. A backup DNA repair pathway moves to the forefront. Cell. 131: 223-5. PMID 17956720 DOI: 10.1016/j.cell.2007.10.005  0.52
2007 Difilippantonio S, Nussenzweig A. The NBS1-ATM connection revisited. Cell Cycle (Georgetown, Tex.). 6: 2366-70. PMID 17881893 DOI: 10.4161/cc.6.19.4758  0.92
2007 Curry JD, Schulz D, Guidos CJ, Danska JS, Nutter L, Nussenzweig A, Schlissel MS. Chromosomal reinsertion of broken RSS ends during T cell development. The Journal of Experimental Medicine. 204: 2293-303. PMID 17785508 DOI: 10.1084/jem.20070583  0.52
2007 Jankovic M, Nussenzweig A, Nussenzweig MC. Antigen receptor diversification and chromosome translocations. Nature Immunology. 8: 801-8. PMID 17641661 DOI: 10.1038/ni1498  0.52
2007 Kim JA, Kruhlak M, Dotiwala F, Nussenzweig A, Haber JE. Heterochromatin is refractory to γ-H2AX modification in yeast and mammals Journal of Cell Biology. 178: 209-218. PMID 17635934 DOI: 10.1083/jcb.200612031  0.52
2007 Callén E, Jankovic M, Difilippantonio S, Daniel JA, Chen HT, Celeste A, Pellegrini M, McBride K, Wangsa D, Bredemeyer AL, Sleckman BP, Ried T, Nussenzweig M, Nussenzweig A. ATM Prevents the Persistence and Propagation of Chromosome Breaks in Lymphocytes Cell. 130: 63-75. PMID 17599403 DOI: 10.1016/j.cell.2007.06.016  0.52
2007 Downs JA, Nussenzweig MC, Nussenzweig A. Chromatin dynamics and the preservation of genetic information. Nature. 447: 951-8. PMID 17581578 DOI: 10.1038/nature05980  0.52
2007 Ramiro A, Reina San-Martin B, McBride K, Jankovic M, Barreto V, Nussenzweig A, Nussenzweig MC. The role of activation-induced deaminase in antibody diversification and chromosome translocations. Advances in Immunology. 94: 75-107. PMID 17560272 DOI: 10.1016/S0065-2776(06)94003-6  0.52
2007 Kruhlak M, Crouch EE, Orlov M, Montaño C, Gorski SA, Nussenzweig A, Misteli T, Phair RD, Casellas R. The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks. Nature. 447: 730-4. PMID 17554310 DOI: 10.1038/nature05842  0.52
2007 Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature. 447: 725-9. PMID 17554309 DOI: 10.1038/nature05862  0.52
2007 Soutoglou E, Dorn JF, Sengupta K, Jasin M, Nussenzweig A, Ried T, Danuser G, Misteli T. Positional stability of single double-strand breaks in mammalian cells. Nature Cell Biology. 9: 675-82. PMID 17486118 DOI: 10.1038/ncb1591  0.52
2007 Difilippantonio S, Celeste A, Kruhlak MJ, Lee Y, Difilippantonio MJ, Feigenbaum L, Jackson SP, McKinnon PJ, Nussenzweig A. Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis. The Journal of Experimental Medicine. 204: 1003-11. PMID 17485521 DOI: 10.1084/jem.20070319  0.92
2007 Kuznetsov S, Pellegrini M, Shuda K, Fernandez-Capetillo O, Liu Y, Martin BK, Burkett S, Southon E, Pati D, Tessarollo L, West SC, Donovan PJ, Nussenzweig A, Sharan SK. RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. The Journal of Cell Biology. 176: 581-92. PMID 17312021 DOI: 10.1083/jcb.200608130  0.52
2007 Reina-San-Martin B, Chen J, Nussenzweig A, Nussenzweig MC. Enhanced intra-switch region recombination during immunoglobulin class switch recombination in 53BP1-/- B cells. European Journal of Immunology. 37: 235-9. PMID 17183606 DOI: 10.1002/eji.200636789  0.52
2006 Kruhlak MJ, Celeste A, Nussenzweig A. Spatio-temporal dynamics of chromatin containing DNA breaks. Cell Cycle (Georgetown, Tex.). 5: 1910-2. PMID 16929171 DOI: 10.4161/cc.5.17.3169  0.52
2006 Ramiro AR, Nussenzweig MC, Nussenzweig A. Switching on chromosomal translocations. Cancer Research. 66: 7837-9. PMID 16912154 DOI: 10.1158/0008-5472.CAN-06-0863  0.52
2006 Pellegrini M, Celeste A, Difilippantonio S, Guo R, Wang W, Feigenbaum L, Nussenzweig A. Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo. Nature. 443: 222-5. PMID 16906133 DOI: 10.1038/nature05112  0.92
2006 Kruhlak MJ, Celeste A, Dellaire G, Fernandez-Capetillo O, Müller WG, McNally JG, Bazett-Jones DP, Nussenzweig A. Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks. The Journal of Cell Biology. 172: 823-34. PMID 16520385 DOI: 10.1083/jcb.200510015  0.52
2006 Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, Manis JP, van Deursen J, Nussenzweig A, Paull TT, Alt FW, Chen J. MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Molecular Cell. 21: 187-200. PMID 16427009 DOI: 10.1016/j.molcel.2005.11.025  0.52
2006 Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, Eisenreich TR, Chen J, Dickins RA, Lowe SW, Nussenzweig A, Nussenzweig MC. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature. 440: 105-9. PMID 16400328 DOI: 10.1038/nature04495  0.52
2005 Ward IM, Difilippantonio S, Minn K, Mueller MD, Molina JR, Yu X, Frisk CS, Ried T, Nussenzweig A, Chen J. 53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice Molecular and Cellular Biology. 25: 10079-10086. PMID 16260621 DOI: 10.1128/MCB.25.22.10079-10086.2005  0.52
2005 Dmitrieva NI, Celeste A, Nussenzweig A, Burg MB. Ku86 preserves chromatin integrity in cells adapted to high NaCl. Proceedings of the National Academy of Sciences of the United States of America. 102: 10730-5. PMID 16027367 DOI: 10.1073/pnas.0504870102  0.52
2005 Difilippantonio S, Celeste A, Fernandez-Capetillo O, Chen HT, Reina San Martin B, Van Laethem F, Yang YP, Petukhova GV, Eckhaus M, Feigenbaum L, Manova K, Kruhlak M, Camerini-Otero RD, Sharan S, Nussenzweig M, ... Nussenzweig A, et al. Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. Nature Cell Biology. 7: 675-85. PMID 15965469 DOI: 10.1038/ncb1270  0.52
2005 Reina-San-Martin B, Nussenzweig MC, Nussenzweig A, Difilippantonio S. Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1. Proceedings of the National Academy of Sciences of the United States of America. 102: 1590-5. PMID 15668392 DOI: 10.1073/pnas.0406289102  0.92
2005 Lee AC, Fernandez-Capetillo O, Pisupati V, Jackson SP, Nussenzweig A. Specific association of mouse MDC1/NFBD1 with NBS1 at sites of DNA-damage. Cell Cycle (Georgetown, Tex.). 4: 177-82. PMID 15611643  0.88
2005 Turner JM, Mahadevaiah SK, Fernandez-Capetillo O, Nussenzweig A, Xu X, Deng CX, Burgoyne PS. Silencing of unsynapsed meiotic chromosomes in the mouse. Nature Genetics. 37: 41-7. PMID 15580272 DOI: 10.1038/ng1484  0.88
2004 Reina-San-Martin B, Chen HT, Nussenzweig A, Nussenzweig MC. ATM is required for efficient recombination between immunoglobulin switch regions. The Journal of Experimental Medicine. 200: 1103-10. PMID 15520243 DOI: 10.1084/jem.20041162  0.52
2004 Coppola V, Barrick CA, Southon EA, Celeste A, Wang K, Chen B, Haddad el-B, Yin J, Nussenzweig A, Subramaniam A, Tessarollo L. Ablation of TrkA function in the immune system causes B cell abnormalities. Development (Cambridge, England). 131: 5185-95. PMID 15459109 DOI: 10.1242/dev.01383  0.52
2004 Sengupta S, Robles AI, Linke SP, Sinogeeva NI, Zhang R, Pedeux R, Ward IM, Celeste A, Nussenzweig A, Chen J, Halazonetis TD, Harris CC. Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. The Journal of Cell Biology. 166: 801-13. PMID 15364958 DOI: 10.1083/jcb.200405128  0.52
2004 Ramiro AR, Jankovic M, Eisenreich T, Difilippantonio S, Chen-Kiang S, Muramatsu M, Honjo T, Nussenzweig A, Nussenzweig MC. AID is required for c-myc/IgH chromosome translocations in vivo. Cell. 118: 431-8. PMID 15315756 DOI: 10.1016/j.cell.2004.08.006  0.92
2004 Daniel R, Ramcharan J, Rogakou E, Taganov KD, Greger JG, Bonner W, Nussenzweig A, Katz RA, Skalka AM. Histone H2AX is phosphorylated at sites of retroviral DNA integration but is dispensable for postintegration repair. The Journal of Biological Chemistry. 279: 45810-4. PMID 15308627 DOI: 10.1074/jbc.M407886200  0.52
2004 Fernandez-Capetillo O, Lee A, Nussenzweig M, Nussenzweig A. H2AX: the histone guardian of the genome. Dna Repair. 3: 959-67. PMID 15279782 DOI: 10.1016/j.dnarep.2004.03.024  0.88
2004 Fernandez-Capetillo O, Nussenzweig A. Aging counts on chromosomes. Nature Genetics. 36: 672-4. PMID 15226747 DOI: 10.1038/ng0704-672  0.88
2004 Fernandez-Capetillo O, Allis CD, Nussenzweig A. Phosphorylation of histone H2B at DNA double-strand breaks Journal of Experimental Medicine. 199: 1671-1677. PMID 15197225 DOI: 10.1084/jem.20032247  0.52
2004 Couëdel C, Mills KD, Barchi M, Shen L, Olshen A, Johnson RD, Nussenzweig A, Essers J, Kanaar R, Li GC, Alt FW, Jasin M. Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells. Genes & Development. 18: 1293-304. PMID 15175261 DOI: 10.1101/gad.1209204  0.52
2004 Ward IM, Reina-San-Martin B, Olaru A, Minn K, Tamada K, Lau JS, Cascalho M, Chen L, Nussenzweig A, Livak F, Nussenzweig MC, Chen J. 53BP1 is required for class switch recombination. The Journal of Cell Biology. 165: 459-64. PMID 15159415 DOI: 10.1083/jcb.200403021  0.52
2004 Fernandez-Capetillo O, Nussenzweig A. Linking histone deacetylation with the repair of DNA breaks. Proceedings of the National Academy of Sciences of the United States of America. 101: 1427-8. PMID 14757822 DOI: 10.1073/pnas.0307342101  0.88
2003 Fernandez-Capetillo O, Liebe B, Scherthan H, Nussenzweig A. H2AX regulates meiotic telomere clustering. The Journal of Cell Biology. 163: 15-20. PMID 14530383 DOI: 10.1083/jcb.200305124  0.88
2003 Fernandez-Capetillo O, Celeste A, Nussenzweig A. Focusing on foci: H2AX and the recruitment of DNA-damage response factors. Cell Cycle (Georgetown, Tex.). 2: 426-7. PMID 12963833  0.88
2003 Rockwood LD, Nussenzweig A, Janz S. Paradoxical decrease in mutant frequencies and chromosomal rearrangements in a transgenic lacZ reporter gene in Ku80 null mice deficient in DNA double strand break repair Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 529: 51-58. PMID 12943919 DOI: 10.1016/S0027-5107(03)00108-8  0.52
2003 Celeste A, Difilippantonio S, Difilippantonio MJ, Fernandez-Capetillo O, Pilch DR, Sedelnikova OA, Eckhaus M, Ried T, Bonner WM, Nussenzweig A. H2AX haploinsufficiency modifies genomic stability and tumor susceptibility Cell. 114: 371-383. PMID 12914701 DOI: 10.1016/S0092-8674(03)00567-1  0.52
2003 Reina-San-Martin B, Difilippantonio S, Hanitsch L, Masilamani RF, Nussenzweig A, Nussenzweig MC. H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation. The Journal of Experimental Medicine. 197: 1767-78. PMID 12810694 DOI: 10.1084/jem.20030569  0.92
2003 Celeste A, Fernandez-Capetillo O, Kruhlak MJ, Pilch DR, Staudt DW, Lee A, Bonner RF, Bonner WM, Nussenzweig A. Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nature Cell Biology. 5: 675-9. PMID 12792649 DOI: 10.1038/ncb1004  0.52
2003 Fernandez-Capetillo O, Mahadevaiah SK, Celeste A, Romanienko PJ, Camerini-Otero RD, Bonner WM, Manova K, Burgoyne P, Nussenzweig A. H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis. Developmental Cell. 4: 497-508. PMID 12689589 DOI: 10.1016/S1534-5807(03)00093-5  0.52
2002 Fernandez-Capetillo O, Chen HT, Celeste A, Ward I, Romanienko PJ, Morales JC, Naka K, Xia Z, Camerini-Otero RD, Motoyama N, Carpenter PB, Bonner WM, Chen J, Nussenzweig A. DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nature Cell Biology. 4: 993-7. PMID 12447390 DOI: 10.1038/ncb884  0.88
2002 Celeste A, Petersen S, Romanienko PJ, Fernandez-Capetillo O, Chen HT, Sedelnikova OA, Reina-San-Martin B, Coppola V, Meffre E, Difilippantonio MJ, Redon C, Pilch DR, Olaru A, Eckhaus M, Camerini-Otero RD, ... ... Nussenzweig A, et al. Genomic instability in mice lacking histone H2AX. Science (New York, N.Y.). 296: 922-7. PMID 11934988 DOI: 10.1126/science.1069398  0.52
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