Andre Nussenzweig, Ph.D. - Publications

Affiliations: 
Center for Cancer Research National Cancer Institute, NIH, Bethesda, Bethesda, MD, United States 
Area:
genomic Instability, DNA damage/repair, recombination/replication
Website:
https://ccr.cancer.gov/Laboratory-of-Genome-Integrity/andre-nussenzweig

223 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Pavani R, Tripathi V, Vrtis KB, Zong D, Chari R, Callen E, Pankajam AV, Zhen G, Matos-Rodrigues G, Yang J, Wu S, Reginato G, Wu W, Cejka P, Walter JC, ... Nussenzweig A, et al. Structure and repair of replication-coupled DNA breaks. Science (New York, N.Y.). eado3867. PMID 38900911 DOI: 10.1126/science.ado3867  0.49
2024 Zhang L, Hsu JI, Braekeleer ED, Chen CW, Patel TD, Martell AG, Guzman AG, Wohlan K, Waldvogel SM, Uryu H, Tovy A, Callen E, Murdaugh RL, Richard R, Jansen S, ... ... Nussenzweig A, et al. is a synthetic-lethal target in -mutant leukemia cells. Elife. 12. PMID 38896450 DOI: 10.7554/eLife.91611  0.313
2024 Hisey JA, Radchenko EA, Mandel NH, McGinty RJ, Matos-Rodrigues G, Rastokina A, Masnovo C, Ceschi S, Hernandez A, Nussenzweig A, Mirkin SM. Pathogenic CANVAS (AAGGG)n repeats stall DNA replication due to the formation of alternative DNA structures. Nucleic Acids Research. PMID 38381906 DOI: 10.1093/nar/gkae124  0.38
2024 van de Kooij B, Schreuder A, Pavani R, Garzero V, Uruci S, Wendel TJ, van Hoeck A, San Martin Alonso M, Everts M, Koerse D, Callen E, Boom J, Mei H, Cuppen E, Luijsterburg MS, ... ... Nussenzweig A, et al. EXO1 protects BRCA1-deficient cells against toxic DNA lesions. Molecular Cell. 84: 659-674.e7. PMID 38266640 DOI: 10.1016/j.molcel.2023.12.039  0.487
2023 Paiano J, Nussenzweig A. Nascent DNA sequencing and its diverse applications in genome integrity research. Methods in Cell Biology. 182: 67-81. PMID 38359988 DOI: 10.1016/bs.mcb.2022.12.011  0.494
2023 Zong D, Koussa NC, Cornwell JA, Pankajam AV, Kruhlak MJ, Wong N, Chari R, Cappell SD, Nussenzweig A. Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR. Genes & Development. 37: 913-928. PMID 37932011 DOI: 10.1101/gad.351085.123  0.347
2023 Matos-Rodrigues G, Hisey JA, Nussenzweig A, Mirkin SM. Detection of alternative DNA structures and its implications for human disease. Molecular Cell. 83: 3622-3641. PMID 37863029 DOI: 10.1016/j.molcel.2023.08.018  0.433
2023 Zhang L, Hsu JI, Braekeleer ED, Chen CW, Patel TD, Urya H, Guzman AG, Martell AG, Waldvogel SM, Tovy A, Callen E, Murdaugh R, Richard R, Jansen S, Vissers L, ... ... Nussenzweig A, et al. is a synthetic lethal target in -mutant leukemia cells. Biorxiv : the Preprint Server For Biology. PMID 37693622 DOI: 10.1101/2023.08.31.555634  0.365
2023 Zong D, Koussa NC, Cornwell JA, Pankajam AV, Kruhlak MJ, Wong N, Chari R, Cappell SD, Nussenzweig A. Comprehensive mapping of cell fates in microsatellite unstable cancer cells support dual targeting of WRN and ATR. Biorxiv : the Preprint Server For Biology. PMID 37662356 DOI: 10.1101/2023.07.28.550976  0.363
2023 Hisey JA, Radchenko EA, Ceschi S, Rastokina A, Mandel NH, McGinty RJ, Matos-Rodrigues G, Hernandez A, Nussenzweig A, Mirkin SM. Pathogenic CANVAS (AAGGG) repeats stall DNA replication due to the formation of alternative DNA structures. Biorxiv : the Preprint Server For Biology. PMID 37546920 DOI: 10.1101/2023.07.25.550509  0.429
2023 Zagelbaum J, Schooley A, Zhao J, Schrank BR, Callen E, Zha S, Gottesman ME, Nussenzweig A, Rabadan R, Dekker J, Gautier J. Author Correction: Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization. Nature Structural & Molecular Biology. PMID 37059902 DOI: 10.1038/s41594-023-00994-w  0.435
2023 Saayman X, Graham E, Nathan WJ, Nussenzweig A, Esashi F. Centromeres as universal hotspots of DNA breakage, driving RAD51-mediated recombination during quiescence. Molecular Cell. PMID 36702125 DOI: 10.1016/j.molcel.2023.01.004  0.533
2022 Zagelbaum J, Schooley A, Zhao J, Schrank BR, Callen E, Zha S, Gottesman ME, Nussenzweig A, Rabadan R, Dekker J, Gautier J. Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization. Nature Structural & Molecular Biology. PMID 36564591 DOI: 10.1038/s41594-022-00893-6  0.483
2022 Ciccia A, Greenberg RA, Lees-Miller SP, Nussenzweig A. A genetic roadmap to the response to genotoxic agents in human cells. Faculty Reviews. 11: 35. PMID 36532708 DOI: 10.12703/r-01-0000019  0.428
2022 Wang D, Wu W, Callen E, Pavani R, Zolnerowich N, Kodali S, Zong D, Wong N, Noriega S, Nathan WJ, Matos-Rodrigues G, Chari R, Kruhlak MJ, Livak F, Ward M, ... ... Nussenzweig A, et al. Active DNA demethylation promotes cell fate specification and the DNA damage response. Science (New York, N.Y.). 378: 983-989. PMID 36454826 DOI: 10.1126/science.add9838  0.444
2022 Matos-Rodrigues G, van Wietmarschen N, Wu W, Tripathi V, Koussa NC, Pavani R, Nathan WJ, Callen E, Belinky F, Mohammed A, Napierala M, Usdin K, Ansari AZ, Mirkin SM, Nussenzweig A. S1-END-seq reveals DNA secondary structures in human cells. Molecular Cell. PMID 36075220 DOI: 10.1016/j.molcel.2022.08.007  0.501
2022 Borel V, Boeing S, Van Wietmarschen N, Sridharan S, Hill BR, Ombrato L, Perez-Lloret J, Jackson D, Goldstone R, Boulton SJ, Nussenzweig A, Bellelli R. Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis. Cell Reports. 39: 110871. PMID 35649380 DOI: 10.1016/j.celrep.2022.110871  0.36
2022 Fowler FC, Chen BR, Zolnerowich N, Wu W, Pavani R, Paiano J, Peart C, Chen Z, Nussenzweig A, Sleckman BP, Tyler JK. DNA-PK promotes DNA end resection at DNA double strand breaks in G cells. Elife. 11. PMID 35575473 DOI: 10.7554/eLife.74700  0.462
2022 Pommier Y, Nussenzweig A, Takeda S, Austin C. Human topoisomerases and their roles in genome stability and organization. Nature Reviews. Molecular Cell Biology. PMID 35228717 DOI: 10.1038/s41580-022-00452-3  0.407
2022 Setiaputra D, Escribano-Díaz C, Reinert JK, Sadana P, Zong D, Callen E, Sifri C, Seebacher J, Nussenzweig A, Thomä NH, Durocher D. RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1. Molecular Cell. PMID 35216668 DOI: 10.1016/j.molcel.2022.01.025  0.455
2022 Caldecott KW, Ward ME, Nussenzweig A. The threat of programmed DNA damage to neuronal genome integrity and plasticity. Nature Genetics. 54: 115-120. PMID 35145299 DOI: 10.1038/s41588-021-01001-y  0.37
2021 Bronder D, Tighe A, Wangsa D, Zong D, Meyer TJ, Wardenaar R, Minshall P, Hirsch D, Heselmeyer-Haddad K, Nelson L, Spierings D, McGrail JC, Cam M, Nussenzweig A, Foijer F, et al. TP53 loss initiates chromosomal instability in fallopian tube epithelial cells. Disease Models & Mechanisms. PMID 34569598 DOI: 10.1242/dmm.049001  0.375
2021 Paiano J, Zolnerowich N, Wu W, Pavani R, Wang C, Li H, Zheng L, Shen B, Sleckman BP, Chen BR, Nussenzweig A. Role of 53BP1 in end protection and DNA synthesis at DNA breaks. Genes & Development. PMID 34503990 DOI: 10.1101/gad.348667.121  0.473
2021 Chen BR, Wang Y, Tubbs A, Zong D, Fowler FC, Zolnerowich N, Wu W, Bennett A, Chen CC, Feng W, Nussenzweig A, Tyler JK, Sleckman BP. LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells. Elife. 10. PMID 34477552 DOI: 10.7554/eLife.68466  0.473
2021 Mei Q, Fitzgerald DM, Liu J, Xia J, Pribis JP, Zhai Y, Nehring RB, Paiano J, Li H, Nussenzweig A, Hastings PJ, Rosenberg SM. Two mechanisms of chromosome fragility at replication-termination sites in bacteria. Science Advances. 7. PMID 34144978 DOI: 10.1126/sciadv.abe2846  0.478
2021 Zatreanu D, Robinson HMR, Alkhatib O, Boursier M, Finch H, Geo L, Grande D, Grinkevich V, Heald RA, Langdon S, Majithiya J, McWhirter C, Martin NMB, Moore S, Neves J, ... ... Nussenzweig A, et al. Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance. Nature Communications. 12: 3636. PMID 34140467 DOI: 10.1038/s41467-021-23463-8  0.437
2021 Ramsden DA, Nussenzweig A. Mechanisms driving chromosomal translocations: lost in time and space. Oncogene. 40: 4263-4270. PMID 34103687 DOI: 10.1038/s41388-021-01856-9  0.306
2021 Shinoda K, Zong D, Callen E, Wu W, Dumitrache LC, Belinky F, Chari R, Wong N, Ishikawa M, Stanlie A, Multhaupt-Buell T, Sharma N, Ozelius L, Ehrlich M, McKinnon PJ, ... Nussenzweig A, et al. The dystonia gene THAP1 controls DNA double-strand break repair choice. Molecular Cell. PMID 33857404 DOI: 10.1016/j.molcel.2021.03.034  0.487
2021 Wu W, Hill SE, Nathan WJ, Paiano J, Callen E, Wang D, Shinoda K, van Wietmarschen N, Colón-Mercado JM, Zong D, De Pace R, Shih HY, Coon S, Parsadanian M, Pavani R, ... ... Nussenzweig A, et al. Neuronal enhancers are hotspots for DNA single-strand break repair. Nature. PMID 33767446 DOI: 10.1038/s41586-021-03468-5  0.449
2021 Feldhahn N, Ferretti E, Robbiani DF, Callen E, Deroubaix S, Selleri L, Nussenzweig A, Nussenzweig MC. The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo. The Embo Journal. 40: e107130. PMID 33448440 DOI: 10.15252/embj.2020107130  0.469
2021 Wong N, John S, Nussenzweig A, Canela A. END-seq: An Unbiased, High-Resolution, and Genome-Wide Approach to Map DNA Double-Strand Breaks and Resection in Human Cells. Methods in Molecular Biology (Clifton, N.J.). 2153: 9-31. PMID 32840769 DOI: 10.1007/978-1-0716-0644-5_2  0.567
2020 van Wietmarschen N, Sridharan S, Nathan WJ, Tubbs A, Chan EM, Callen E, Wu W, Belinky F, Tripathi V, Wong N, Foster K, Noorbakhsh J, Garimella K, Cruz-Migoni A, Sommers JA, ... ... Nussenzweig A, et al. Repeat expansions confer WRN dependence in microsatellite-unstable cancers. Nature. PMID 32999459 DOI: 10.1038/s41586-020-2769-8  0.492
2020 Zong D, Oberdoerffer P, Batista PJ, Nussenzweig A. RNA: a double-edged sword in genome maintenance. Nature Reviews. Genetics. PMID 32764716 DOI: 10.1038/S41576-020-0263-7  0.376
2020 He Y, Ren J, Xu X, Ni K, Schwader A, Finney R, Wang C, Sun L, Klarmann K, Keller J, Tubbs A, Nussenzweig A, Muegge K. Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination. Proceedings of the National Academy of Sciences of the United States of America. PMID 32727902 DOI: 10.1073/Pnas.2004112117  0.476
2020 Feng X, Tubbs A, Zhang C, Tang M, Sridharan S, Wang C, Jiang D, Su D, Zhang H, Chen Z, Nie L, Xiong Y, Huang M, Nussenzweig A, Chen J. ATR inhibition potentiates ionizing radiation-induced interferon response via cytosolic nucleic acid-sensing pathways. The Embo Journal. e104036. PMID 32484965 DOI: 10.15252/Embj.2019104036  0.5
2020 Nacson J, Di Marcantonio D, Wang Y, Bernhardy AJ, Clausen E, Hua X, Cai KQ, Martinez E, Feng W, Callén E, Wu W, Gupta GP, Testa JR, Nussenzweig A, Sykes SM, et al. BRCA1 Mutational Complementation Induces Synthetic Viability. Molecular Cell. PMID 32359443 DOI: 10.1016/J.Molcel.2020.04.006  0.421
2020 Mahgoub M, Paiano J, Bruno M, Wu W, Pathuri S, Zhang X, Ralls S, Cheng X, Nussenzweig A, Macfarlan TS. Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks in male mice. Elife. 9. PMID 32352380 DOI: 10.7554/Elife.53360  0.533
2020 Chu SH, Chabon JR, Matovina CN, Minehart JC, Chen BR, Zhang J, Kumar V, Xiong Y, Callen E, Hung PJ, Feng Z, Koche RP, Liu XS, Chaudhuri J, Nussenzweig A, et al. Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development. Iscience. 23: 100941. PMID 32169821 DOI: 10.1016/J.Isci.2020.100941  0.544
2020 Sciascia N, Wu W, Zong D, Sun Y, Wong N, John S, Wangsa D, Ried T, Bunting SF, Pommier Y, Nussenzweig A. Suppressing proteasome mediated processing of Topoisomerase II DNA-protein complexes preserves genome integrity. Elife. 9. PMID 32057297 DOI: 10.7554/Elife.53447  0.597
2020 Paiano J, Wu W, Yamada S, Sciascia N, Callen E, Paola Cotrim A, Deshpande RA, Maman Y, Day A, Paull TT, Nussenzweig A. ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis. Nature Communications. 11: 857. PMID 32051414 DOI: 10.1038/S41467-020-14654-W  0.45
2020 Sciascia N, Wu W, Zong D, Sun Y, Wong N, John S, Wangsa D, Ried T, Bunting SF, Pommier Y, Nussenzweig A. Author response: Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity Elife. DOI: 10.7554/Elife.53447.Sa2  0.45
2020 Mahgoub M, Paiano J, Bruno M, Wu W, Pathuri S, Zhang X, Ralls S, Cheng X, Nussenzweig A, Macfarlan TS. Author response: Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks in male mice Elife. DOI: 10.7554/Elife.53360.Sa2  0.415
2019 Shinoda K, Maman Y, Canela A, Schatz DG, Livak F, Nussenzweig A. Intra-Vκ Cluster Recombination Shapes the Ig Kappa Locus Repertoire. Cell Reports. 29: 4471-4481.e6. PMID 31875554 DOI: 10.1016/J.Celrep.2019.11.088  0.366
2019 Eke I, Zong D, Aryankalayil MJ, Sandfort V, Bylicky MA, Rath BH, Graves EE, Nussenzweig A, Coleman CN. 53BP1/RIF1 signaling promotes cell survival after multifractionated radiotherapy. Nucleic Acids Research. PMID 31822909 DOI: 10.1093/Nar/Gkz1139  0.413
2019 Livak F, Nussenzweig A. One ring to rule them all. Nature. 575: 291-293. PMID 31719691 DOI: 10.1038/D41586-019-03200-4  0.501
2019 Callen E, Zong D, Wu W, Wong N, Stanlie A, Ishikawa M, Pavani R, Dumitrache LC, Byrum AK, Mendez-Dorantes C, Martinez P, Canela A, Maman Y, Day A, Kruhlak MJ, ... ... Nussenzweig A, et al. 53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination. Molecular Cell. PMID 31653568 DOI: 10.1016/J.Molcel.2019.09.024  0.557
2019 Yin M, Baslan T, Walker RL, Zhu YJ, Freeland A, Matsukawa T, Sridharan S, Nussenzweig A, Pruitt SC, Lowe SW, Meltzer PS, Aplan PD. A unique mutator phenotype reveals complementary oncogenic lesions leading to acute leukemia. Jci Insight. PMID 31622281 DOI: 10.1172/Jci.Insight.131434  0.513
2019 Canela A, Maman Y, Huang SN, Wutz G, Tang W, Zagnoli-Vieira G, Callen E, Wong N, Day A, Peters JM, Caldecott KW, Pommier Y, Nussenzweig A. Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity. Molecular Cell. PMID 31202577 DOI: 10.1016/J.Molcel.2019.04.030  0.583
2019 Zong D, Adam S, Wang Y, Sasanuma H, Callén E, Murga M, Day A, Kruhlak MJ, Wong N, Munro M, Ray Chaudhuri A, Karim B, Xia B, Takeda S, Johnson N, ... ... Nussenzweig A, et al. BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation. Molecular Cell. PMID 30704900 DOI: 10.1016/J.Molcel.2018.12.010  0.59
2018 Nacson J, Krais JJ, Bernhardy AJ, Clausen E, Feng W, Wang Y, Nicolas E, Cai KQ, Tricarico R, Hua X, DiMarcantonio D, Martinez E, Zong D, Handorf EA, Bellacosa A, ... ... Nussenzweig A, et al. BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance. Cell Reports. 25: 1384. PMID 30380426 DOI: 10.1016/J.Celrep.2018.10.009  0.326
2018 Sasanuma H, Tsuda M, Morimoto S, Saha LK, Rahman MM, Kiyooka Y, Fujiike H, Cherniack AD, Itou J, Callen Moreu E, Toi M, Nakada S, Tanaka H, Tsutsui K, Yamada S, ... Nussenzweig A, et al. BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes. Proceedings of the National Academy of Sciences of the United States of America. PMID 30352856 DOI: 10.1073/Pnas.1803177115  0.474
2018 Das P, Veazey KJ, Van HT, Kaushik S, Lin K, Lu Y, Ishii M, Kikuta J, Ge K, Nussenzweig A, Santos MA. Histone methylation regulator PTIP is required to maintain normal and leukemic bone marrow niches. Proceedings of the National Academy of Sciences of the United States of America. PMID 30297393 DOI: 10.1073/Pnas.1806019115  0.32
2018 Chu SH, Song EJ, Chabon JR, Minehart J, Matovina CN, Makofske JL, Frank ES, Ross K, Koche RP, Feng Z, Xu H, Krivtsov A, Nussenzweig A, Armstrong SA. Inhibition of MEK and ATR is effective in a B-cell acute lymphoblastic leukemia model driven by and activated . Blood Advances. 2: 2478-2490. PMID 30266823 DOI: 10.1182/Bloodadvances.2018021592  0.333
2018 Nacson J, Krais JJ, Bernhardy AJ, Clausen E, Feng W, Wang Y, Nicolas E, Cai KQ, Tricarico R, Hua X, DiMarcantonio D, Martinez E, Zong D, Handorf EA, Bellacosa A, ... ... Nussenzweig A, et al. BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance. Cell Reports. 24: 3513-3527.e7. PMID 30257212 DOI: 10.1016/J.Celrep.2018.08.086  0.461
2018 van Wietmarschen N, Nussenzweig A. Mechanism for Synthetic Lethality in BRCA-Deficient Cancers: No Longer Lagging Behind. Molecular Cell. 71: 877-878. PMID 30241603 DOI: 10.1016/J.Molcel.2018.08.045  0.427
2018 Tubbs A, Sridharan S, van Wietmarschen N, Maman Y, Callen E, Stanlie A, Wu W, Wu X, Day A, Wong N, Yin M, Canela A, Fu H, Redon C, Pruitt SC, ... ... Nussenzweig A, et al. Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse. Cell. PMID 30078706 DOI: 10.1016/J.Cell.2018.07.011  0.41
2018 Vian L, Pękowska A, Rao SSP, Kieffer-Kwon KR, Jung S, Baranello L, Huang SC, El Khattabi L, Dose M, Pruett N, Sanborn AL, Canela A, Maman Y, Oksanen A, Resch W, ... ... Nussenzweig A, et al. The Energetics and Physiological Impact of Cohesin Extrusion. Cell. PMID 29706548 DOI: 10.1016/J.Cell.2018.03.072  0.456
2018 Weyemi U, Paul BD, Snowman AM, Jailwala P, Nussenzweig A, Bonner WM, Snyder SH. Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis. Nature Communications. 9: 1526. PMID 29670103 DOI: 10.1038/S41467-018-03948-9  0.417
2018 Gupta R, Somyajit K, Narita T, Maskey E, Stanlie A, Kremer M, Typas D, Lammers M, Mailand N, Nussenzweig A, Lukas J, Choudhary C. DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity. Cell. PMID 29656893 DOI: 10.1016/J.Cell.2018.03.050  0.561
2018 Gutierrez-Martinez P, Hogdal L, Nagai M, Kruta M, Singh R, Sarosiek K, Nussenzweig A, Beerman I, Letai A, Rossi DJ. Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage. Nature Cell Biology. PMID 29531308 DOI: 10.1038/S41556-018-0054-Y  0.5
2018 Di Siena S, Campolo F, Gimmelli R, Di Pietro C, Marazziti D, Dolci S, Lenzi A, Nussenzweig A, Pellegrini M. Atm reactivation reverses ataxia telangiectasia phenotypes in vivo. Cell Death & Disease. 9: 314. PMID 29472706 DOI: 10.1038/S41419-018-0357-8  0.74
2018 Chu SH, Chabon J, Minehart J, Matovina CN, Zhang J, Chen B, Callen-Moreu E, Hung PJ, Feng Z, Koche R, Liu XS, Chaudhuri J, Nussenzweig A, Sleckman B, Armstrong SA. The Lysine Histone Methyltransferase SETD2 Is Required for Appropriate Immunoglobulin VDJ Recombination Blood. 132: 511-511. DOI: 10.1182/Blood-2018-99-111952  0.515
2017 Mijic S, Zellweger R, Chappidi N, Berti M, Jacobs K, Mutreja K, Ursich S, Ray Chaudhuri A, Nussenzweig A, Janscak P, Lopes M. Replication fork reversal triggers fork degradation in BRCA2-defective cells. Nature Communications. 8: 859. PMID 29038466 DOI: 10.1038/S41467-017-01164-5  0.499
2017 Ray Chaudhuri A, Nussenzweig A. Thwarting endogenous stress: BRCA protects against aldehyde toxicity. Embo Molecular Medicine. 9: 1331-1333. PMID 28835508 DOI: 10.15252/Emmm.201708194  0.517
2017 Canela A, Maman Y, Jung S, Wong N, Callen E, Day A, Kieffer-Kwon KR, Pekowska A, Zhang H, Rao SSP, Huang SC, Mckinnon PJ, Aplan PD, Pommier Y, Aiden EL, ... ... Nussenzweig A, et al. Genome Organization Drives Chromosome Fragility. Cell. PMID 28735753 DOI: 10.1016/J.Cell.2017.06.034  0.528
2017 Ray Chaudhuri A, Nussenzweig A. The multifaceted roles of PARP1 in DNA repair and chromatin remodelling. Nature Reviews. Molecular Cell Biology. 18: 610-621. PMID 28676700 DOI: 10.1038/Nrm.2017.53  0.573
2017 Yazinski SA, Comaills V, Buisson R, Genois MM, Nguyen HD, Ho CK, Todorova Kwan T, Morris R, Lauffer S, Nussenzweig A, Ramaswamy S, Benes CH, Haber DA, Maheswaran S, Birrer MJ, et al. ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells. Genes & Development. PMID 28242626 DOI: 10.1101/Gad.290957.116  0.392
2017 Tubbs A, Nussenzweig A. Endogenous DNA Damage as a Source of Genomic Instability in Cancer. Cell. 168: 644-656. PMID 28187286 DOI: 10.1016/J.Cell.2017.01.002  0.486
2017 Greer YE, Gao B, Yang Y, Nussenzweig A, Rubin JS. Lack of Casein Kinase 1 Delta Promotes Genomic Instability - The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1. Plos One. 12: e0170903. PMID 28125685 DOI: 10.1371/Journal.Pone.0170903  0.474
2017 Chaudhuri AR, Callen E, Ding X, Gogola E, Duarte AA, Lee J, Wong N, Lafarga V, Calvo JA, Panzarino NJ, John S, Day A, Crespo AV, Shen B, Starnes LM, ... ... Nussenzweig A, et al. Abstract IA09: Replication fork stability confers chemoresistance in BRCA-deficient cells Molecular Cancer Research. 15. DOI: 10.1158/1557-3125.Dnarepair16-Ia09  0.759
2016 Skau CT, Fischer RS, Gurel P, Thiam HR, Tubbs A, Baird MA, Davidson MW, Piel M, Alushin GM, Nussenzweig A, Steeg PS, Waterman CM. FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis. Cell. PMID 27839864 DOI: 10.1016/J.Cell.2016.10.023  0.431
2016 Chaudhuri AR, Callen E, Ding X, Gogola E, Duarte AA, Lee JE, Wong N, Lafarga V, Calvo JA, Panzarino NJ, John S, Day A, Crespo AV, Shen B, Starnes LM, ... ... Nussenzweig A, et al. Erratum: Replication fork stability confers chemoresistance in BRCA-deficient cells. Nature. PMID 27680696 DOI: 10.1038/nature19826  0.616
2016 Li M, Cole F, Patel DS, Misenko SM, Her J, Malhowski A, Alhamza A, Zheng H, Baer R, Ludwig T, Jasin M, Nussenzweig A, Serrano L, Bunting SF. 53BP1 ablation rescues genomic instability in mice expressing 'RING-less' BRCA1. Embo Reports. PMID 27670884 DOI: 10.15252/Embr.201642497  0.511
2016 Morgado-Palacin I, Day A, Murga M, Lafarga V, Anton ME, Tubbs A, Chen HT, Ergan A, Anderson R, Bhandoola A, Pike KG, Barlaam B, Cadogan E, Wang X, Pierce AJ, ... ... Nussenzweig A, et al. Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML. Science Signaling. 9: ra91. PMID 27625305 DOI: 10.1126/Scisignal.Aad8243  0.745
2016 Nieto-Soler M, Morgado-Palacin I, Lafarga V, Lecona E, Murga M, Callen E, Azorin D, Alonso J, Lopez-Contreras AJ, Nussenzweig A, Fernandez-Capetillo O. Efficacy of ATR inhibitors as single agents in Ewing sarcoma. Oncotarget. 7: 58759-58767. PMID 27577084 DOI: 10.18632/Oncotarget.11643  0.665
2016 Ding X, Chaudhuri AR, Callen E, Pang Y, Biswas K, Klarmann KD, Martin BK, Burkett S, Cleveland L, Stauffer S, Sullivan T, Dewan A, Marks H, Tubbs AT, Wong N, ... ... Nussenzweig A, et al. Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies. Nature Communications. 7: 12425. PMID 27498558 DOI: 10.1038/Ncomms12425  0.425
2016 Zong D, Chaudhuri AR, Nussenzweig A. More end resection is not merrier. Nature Structural & Molecular Biology. 23: 699-701. PMID 27487392 DOI: 10.1038/Nsmb.3274  0.559
2016 Canela A, Sridharan S, Sciascia N, Tubbs A, Meltzer P, Sleckman BP, Nussenzweig A. DNA Breaks and End Resection Measured Genome-wide by End Sequencing. Molecular Cell. PMID 27477910 DOI: 10.1016/J.Molcel.2016.06.034  0.554
2016 Ray Chaudhuri A, Callen E, Ding X, Gogola E, Duarte AA, Lee JE, Wong N, Lafarga V, Calvo JA, Panzarino NJ, John S, Day A, Crespo AV, Shen B, Starnes LM, ... ... Nussenzweig A, et al. Replication fork stability confers chemoresistance in BRCA-deficient cells. Nature. 535: 382-7. PMID 27443740 DOI: 10.1038/Nature18325  0.762
2016 Starnes LM, Su D, Pikkupeura LM, Weinert BT, Santos MA, Mund A, Soria R, Cho YW, Pozdnyakova I, Kubec Højfeldt M, Vala A, Yang W, López-Méndez B, Lee JE, Peng W, ... ... Nussenzweig A, et al. A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. Genes & Development. PMID 26744420 DOI: 10.1101/Gad.268797.115  0.439
2016 Salewsky B, Hildebrand G, Rothe S, Parplys AC, Radszewski J, Kieslich M, Wessendorf P, Krenzlin H, Borgmann K, Nussenzweig A, Sperling K, Digweed M. Directed Alternative Splicing in Nijmegen Breakage Syndrome: Proof of Principle Concerning Its Therapeutical Application. Molecular Therapy : the Journal of the American Society of Gene Therapy. 24: 117-24. PMID 26265251 DOI: 10.1038/mt.2015.144  0.328
2016 Ortega-Molina A, Boss IW, Canela A, Pan H, Jiang Y, Zhao C, Jiang M, Hu D, Lee J, Chen H, Ennishi D, Scott DW, Hother C, Liu S, Cao X, ... ... Nussenzweig A, et al. Abstract IA18: Functional characterization of the tumor suppressor lysine-specific methyltransferase KMT2D in lymphoma Cancer Research. 76. DOI: 10.1158/1538-7445.Chromepi15-Ia18  0.353
2015 Cloutier JM, Mahadevaiah SK, ElInati E, Nussenzweig A, Tóth A, Turner JM. Histone H2AFX Links Meiotic Chromosome Asynapsis to Prophase I Oocyte Loss in Mammals. Plos Genetics. 11: e1005462. PMID 26509888 DOI: 10.1371/Journal.Pgen.1005462  0.541
2015 Ortega-Molina A, Boss IW, Canela A, Pan H, Jiang Y, Zhao C, Jiang M, Hu D, Agirre X, Niesvizky I, Lee JE, Chen HT, Ennishi D, Scott DW, Mottok A, ... ... Nussenzweig A, et al. The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development. Nature Medicine. PMID 26366710 DOI: 10.1038/Nm.3943  0.364
2015 Robbiani DF, Deroubaix S, Feldhahn N, Oliveira TY, Callen E, Wang Q, Jankovic M, Silva IT, Rommel PC, Bosque D, Eisenreich T, Nussenzweig A, Nussenzweig MC. Plasmodium Infection Promotes Genomic Instability and AID-Dependent B Cell Lymphoma. Cell. 162: 727-37. PMID 26276629 DOI: 10.1016/J.Cell.2015.07.019  0.403
2015 Canela A, Stanlie A, Nussenzweig A. Collateral DNA damage produced by genome-editing drones: exception or rule? Molecular Cell. 58: 565-7. PMID 26000841 DOI: 10.1016/J.Molcel.2015.05.012  0.42
2015 Zong D, Callén E, Pegoraro G, Lukas C, Lukas J, Nussenzweig A. Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining. Nucleic Acids Research. 43: 4950-61. PMID 25916843 DOI: 10.1093/Nar/Gkv336  0.566
2015 Lopez-Contreras AJ, Specks J, Barlow JH, Ambrogio C, Desler C, Vikingsson S, Rodrigo-Perez S, Green H, Rasmussen LJ, Murga M, Nussenzweig A, Fernandez-Capetillo O. Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice. Genes & Development. 29: 690-5. PMID 25838540 DOI: 10.1101/Gad.256958.114  0.656
2015 Naranjo-Suarez S, Callen E, Zhong Y, Makohon-Moore A, Nussenzweig A, Iacobuzio-Donahue C. Abstract A68: Hypoxia-induced CHK1 repression may enhance the mutator phenotype of pancreatic cancer cells Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-A68  0.455
2015 Patel S, Sukumar M, Palmer D, Roychoudhari R, Roy R, Nussenzweig A, Restifo N. Abstract 1347: Genomic stress in antigen experienced T-lymphocytes Cancer Research. 75: 1347-1347. DOI: 10.1158/1538-7445.Am2015-1347  0.345
2014 Wessendorf P, Vijg J, Nussenzweig A, Digweed M. Deficiency of the DNA repair protein nibrin increases the basal but not the radiation induced mutation frequency in vivo. Mutation Research. 769: 11-6. PMID 25771721 DOI: 10.1016/J.Mrfmmm.2014.07.001  0.506
2014 Santos MA, John S, Nussenzweig A. Tumor promoting role of the DNA damage response. Cell Cycle (Georgetown, Tex.). 13: 2807-8. PMID 25486465 DOI: 10.4161/15384101.2014.959855  0.578
2014 Barlow JH, Nussenzweig A. Replication initiation and genome instability: a crossroads for DNA and RNA synthesis. Cellular and Molecular Life Sciences : Cmls. 71: 4545-59. PMID 25238783 DOI: 10.1007/S00018-014-1721-1  0.56
2014 Santos MA, Faryabi RB, Ergen AV, Day AM, Malhowski A, Canela A, Onozawa M, Lee JE, Callen E, Gutierrez-Martinez P, Chen HT, Wong N, Finkel N, Deshpande A, Sharrow S, ... ... Nussenzweig A, et al. DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier. Nature. 514: 107-11. PMID 25079327 DOI: 10.1038/Nature13483  0.78
2014 Polato F, Callen E, Wong N, Faryabi R, Bunting S, Chen HT, Kozak M, Kruhlak MJ, Reczek CR, Lee WH, Ludwig T, Baer R, Feigenbaum L, Jackson S, Nussenzweig A. CtIP-mediated resection is essential for viability and can operate independently of BRCA1. The Journal of Experimental Medicine. 211: 1027-36. PMID 24842372 DOI: 10.1084/Jem.20131939  0.816
2014 Ira G, Nussenzweig A. A new Riff: Rif1 eats its cake and has it too. Embo Reports. 15: 622-4. PMID 24769453 DOI: 10.1002/Embr.201438825  0.43
2013 Fernandez-Capetillo O, Nussenzweig A. Naked replication forks break apRPArt. Cell. 155: 979-80. PMID 24267882 DOI: 10.1016/J.Cell.2013.10.049  0.716
2013 Lee BS, Gapud EJ, Zhang S, Dorsett Y, Bredemeyer A, George R, Callen E, Daniel JA, Osipovich O, Oltz EM, Bassing CH, Nussenzweig A, Lees-Miller S, Hammel M, Chen BP, et al. Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination. Molecular and Cellular Biology. 33: 3568-79. PMID 23836881 DOI: 10.1128/Mcb.00308-13  0.556
2013 Bunting SF, Nussenzweig A. End-joining, translocations and cancer Nature Reviews Cancer. 13: 443-454. PMID 23760025 DOI: 10.1038/Nrc3537  0.438
2013 Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen HT, Faryabi RB, Polato F, Santos M, Starnes LM, Wesemann DR, Lee JE, Tubbs A, Sleckman BP, Daniel JA, ... ... Nussenzweig A, et al. 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell. 153: 1266-80. PMID 23727112 DOI: 10.1016/J.Cell.2013.05.023  0.846
2013 Daniel JA, Nussenzweig A. The AID-induced DNA damage response in chromatin Molecular Cell. 50: 309-321. PMID 23664375 DOI: 10.1016/J.Molcel.2013.04.017  0.576
2013 Bowman-Colin C, Xia B, Bunting S, Klijn C, Drost R, Bouwman P, Fineman L, Chen X, Culhane AC, Cai H, Rodig SJ, Bronson RT, Jonkers J, Nussenzweig A, Kanellopoulou C, et al. Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 110: 8632-7. PMID 23657012 DOI: 10.1073/Pnas.1305362110  0.446
2013 Barlow JH, Faryabi RB, Callén E, Wong N, Malhowski A, Chen HT, Gutierrez-Cruz G, Sun HW, McKinnon P, Wright G, Casellas R, Robbiani DF, Staudt L, Fernandez-Capetillo O, Nussenzweig A. Identification of early replicating fragile sites that contribute to genome instability. Cell. 152: 620-32. PMID 23352430 DOI: 10.1016/J.Cell.2013.01.006  0.844
2013 Di Virgilio M, Callen E, Yamane A, Zhang W, Jankovic M, Gitlin AD, Feldhahn N, Resch W, Oliveira TY, Chait BT, Nussenzweig A, Casellas R, Robbiani DF, Nussenzweig MC. Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching. Science (New York, N.Y.). 339: 711-5. PMID 23306439 DOI: 10.1126/Science.1230624  0.642
2013 Yamane A, Robbiani DF, Resch W, Bothmer A, Nakahashi H, Oliveira T, Rommel PC, Brown EJ, Nussenzweig A, Nussenzweig MC, Casellas R. RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycle. Cell Reports. 3: 138-47. PMID 23291097 DOI: 10.1016/J.Celrep.2012.12.006  0.5
2013 Bothmer A, Rommel PC, Gazumyan A, Polato F, Reczek CR, Muellenbeck MF, Schaetzlein S, Edelmann W, Chen PL, Brosh RM, Casellas R, Ludwig T, Baer R, Nussenzweig A, Nussenzweig MC, et al. Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching. The Journal of Experimental Medicine. 210: 115-23. PMID 23254285 DOI: 10.1084/Jem.20121975  0.581
2012 Sin HS, Barski A, Zhang F, Kartashov AV, Nussenzweig A, Chen J, Andreassen PR, Namekawa SH. RNF8 regulates active epigenetic modifications and escape gene activation from inactive sex chromosomes in post-meiotic spermatids. Genes & Development. 26: 2737-48. PMID 23249736 DOI: 10.1101/Gad.202713.112  0.441
2012 Callen E, Faryabi RB, Luckey M, Hao B, Daniel JA, Yang W, Sun HW, Dressler G, Peng W, Chi H, Ge K, Krangel MS, Park JH, Nussenzweig A. The DNA Damage- and Transcription-Associated Protein Paxip1 Controls Thymocyte Development and Emigration Immunity. 37: 971-985. PMID 23159437 DOI: 10.1016/J.Immuni.2012.10.007  0.781
2012 Muñoz MC, Laulier C, Gunn A, Cheng A, Robbiani DF, Nussenzweig A, Stark JM. RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1. The Journal of Biological Chemistry. 287: 40618-28. PMID 23055523 DOI: 10.1074/Jbc.M112.410951  0.494
2012 Feldhahn N, Ferretti E, Robbiani DF, Callen E, Deroubaix S, Selleri L, Nussenzweig A, Nussenzweig MC. The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo. The Embo Journal. 31: 4045-56. PMID 22940690 DOI: 10.1038/Emboj.2012.247  0.581
2012 Daniel JA, Pellegrini M, Lee BS, Guo Z, Filsuf D, Belkina NV, You Z, Paull TT, Sleckman BP, Feigenbaum L, Nussenzweig A. Loss of ATM kinase activity leads to embryonic lethality in mice Journal of Cell Biology. 198: 295-304. PMID 22869595 DOI: 10.1083/Jcb.201204035  0.686
2012 Daniel JA, Nussenzweig A. Roles for histone H3K4 methyltransferase activities during immunoglobulin class-switch recombination Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms. 1819: 733-738. PMID 22710321 DOI: 10.1016/J.Bbagrm.2012.01.019  0.427
2012 Bunting SF, Callén E, Kozak ML, Kim JM, Wong N, López-Contreras AJ, Ludwig T, Baer R, Faryabi RB, Malhowski A, Chen HT, Fernandez-Capetillo O, D'Andrea A, Nussenzweig A. BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair. Molecular Cell. 46: 125-35. PMID 22445484 DOI: 10.1016/J.Molcel.2012.02.015  0.862
2012 Hakim O, Resch W, Yamane A, Klein I, Kieffer-Kwon KR, Jankovic M, Oliveira T, Bothmer A, Voss TC, Ansarah-Sobrinho C, Mathe E, Liang G, Cobell J, Nakahashi H, Robbiani DF, ... Nussenzweig A, et al. DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes. Nature. 484: 69-74. PMID 22314321 DOI: 10.1038/Nature10909  0.578
2011 Klein IA, Resch W, Jankovic M, Oliveira T, Yamane A, Nakahashi H, Di Virgilio M, Bothmer A, Nussenzweig A, Robbiani DF, Casellas R, Nussenzweig MC. Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes. Cell. 147: 95-106. PMID 21962510 DOI: 10.1016/J.Cell.2011.07.048  0.464
2011 Bothmer A, Robbiani DF, Di Virgilio M, Bunting SF, Klein IA, Feldhahn N, Barlow J, Chen HT, Bosque D, Callen E, Nussenzweig A, Nussenzweig MC. Regulation of DNA End Joining, Resection, and Immunoglobulin Class Switch Recombination by 53BP1 Molecular Cell. 42: 319-329. PMID 21549309 DOI: 10.1016/J.Molcel.2011.03.019  0.589
2011 Ichijima Y, Ichijima M, Lou Z, Nussenzweig A, Camerini-Otero RD, Chen J, Andreassen PR, Namekawa SH. MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells. Genes & Development. 25: 959-71. PMID 21536735 DOI: 10.1101/Gad.2030811  0.488
2011 Zhang S, Yajima H, Huynh H, Zheng J, Callen E, Chen HT, Wong N, Bunting S, Lin YF, Li M, Lee KJ, Story M, Gapud E, Sleckman BP, Nussenzweig A, et al. Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair. The Journal of Cell Biology. 193: 295-305. PMID 21482716 DOI: 10.1083/Jcb.201009074  0.576
2011 Fernando RN, Eleuteri B, Abdelhady S, Nussenzweig A, Andäng M, Ernfors P. Cell cycle restriction by histone H2AX limits proliferation of adult neural stem cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 5837-42. PMID 21436033 DOI: 10.1073/Pnas.1014993108  0.33
2011 Gapud EJ, Dorsett Y, Yin B, Callen E, Bredemeyer A, Mahowald GK, Omi KQ, Walker LM, Bednarski JJ, McKinnon PJ, Bassing CH, Nussenzweig A, Sleckman BP. Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation. Proceedings of the National Academy of Sciences of the United States of America. 108: 2022-7. PMID 21245316 DOI: 10.1073/Pnas.1013295108  0.58
2011 Pellegrini M, Claps G, Orlova VV, Barrios F, Dolci S, Geremia R, Rossi P, Rossi G, Arnold B, Chavakis T, Feigenbaum L, Sharan SK, Nussenzweig A. Targeted JAM-C deletion in germ cells by Spo11-controlled Cre recombinase. Journal of Cell Science. 124: 91-9. PMID 21147852 DOI: 10.1242/Dev.063149  0.611
2010 Daniel JA, Santos MA, Wang Z, Zang C, Schwab KR, Jankovic M, Filsuf D, Chen HT, Gazumyan A, Yamane A, Cho YW, Sun HW, Ge K, Peng W, Nussenzweig MC, ... ... Nussenzweig A, et al. PTIP promotes chromatin changes critical for immunoglobulin class switch recombination Science. 329: 917-923. PMID 20671152 DOI: 10.1126/Science.1187942  0.455
2010 Bunting SF, Nussenzweig A. Dangerous liaisons: Fanconi anemia and toxic nonhomologous end joining in DNA crosslink repair. Molecular Cell. 39: 164-6. PMID 20670885 DOI: 10.1016/J.Molcel.2010.07.016  0.498
2010 Santos MA, Huen MS, Jankovic M, Chen HT, López-Contreras AJ, Klein IA, Wong N, Barbancho JL, Fernandez-Capetillo O, Nussenzweig MC, Chen J, Nussenzweig A. Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8. The Journal of Experimental Medicine. 207: 973-81. PMID 20385748 DOI: 10.1084/Jem.20092308  0.738
2010 Nussenzweig A, Nussenzweig MC. Origin of chromosomal translocations in lymphoid cancer. Cell. 141: 27-38. PMID 20371343 DOI: 10.1016/J.Cell.2010.03.016  0.386
2010 Bothmer A, Robbiani DF, Feldhahn N, Gazumyan A, Nussenzweig A, Nussenzweig MC. 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. The Journal of Experimental Medicine. 207: 855-65. PMID 20368578 DOI: 10.1084/Jem.20100244  0.589
2010 Bunting SF, Callén E, Wong N, Chen HT, Polato F, Gunn A, Bothmer A, Feldhahn N, Fernandez-Capetillo O, Cao L, Xu X, Deng CX, Finkel T, Nussenzweig M, Stark JM, ... Nussenzweig A, et al. 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell. 141: 243-54. PMID 20362325 DOI: 10.1016/J.Cell.2010.03.012  0.782
2010 Boboila C, Yan C, Wesemann DR, Jankovic M, Wang JH, Manis J, Nussenzweig A, Nussenzweig M, Alt FW. Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4. The Journal of Experimental Medicine. 207: 417-27. PMID 20142431 DOI: 10.1084/Jem.20092449  0.499
2010 Boboila C, Jankovic M, Yan CT, Wang JH, Wesemann DR, Zhang T, Fazeli A, Feldman L, Nussenzweig A, Nussenzweig M, Alt FW. Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proceedings of the National Academy of Sciences of the United States of America. 107: 3034-9. PMID 20133803 DOI: 10.1073/Pnas.0915067107  0.474
2010 Jankovic M, Robbiani DF, Dorsett Y, Eisenreich T, Xu Y, Tarakhovsky A, Nussenzweig A, Nussenzweig MC. Role of the translocation partner in protection against AID-dependent chromosomal translocations. Proceedings of the National Academy of Sciences of the United States of America. 107: 187-92. PMID 19966290 DOI: 10.1073/Pnas.0908946107  0.45
2010 Bunting SF, Nussenzweig A. Dangerous liaisons: Fanconi anemia and toxic nonhomologous end joining in DNA crosslink repair Molecular Cell. 39: 164-166. DOI: 10.1016/j.molcel.2010.07.016  0.398
2009 Robbiani DF, Bunting S, Feldhahn N, Bothmer A, Camps J, Deroubaix S, McBride KM, Klein IA, Stone G, Eisenreich TR, Ried T, Nussenzweig A, Nussenzweig MC. AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Molecular Cell. 36: 631-41. PMID 19941823 DOI: 10.1016/J.Molcel.2009.11.007  0.489
2009 Kawauchi S, Calof AL, Santos R, Lopez-Burks ME, Young CM, Hoang MP, Chua A, Lao T, Lechner MS, Daniel JA, Nussenzweig A, Kitzes L, Yokomori K, Hallgrimsson B, Lander AD. Multiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange Syndrome. Plos Genetics. 5: e1000650. PMID 19763162 DOI: 10.1371/Journal.Pgen.1000650  0.419
2009 Cao L, Xu X, Bunting SF, Liu J, Wang RH, Cao LL, Wu JJ, Peng TN, Chen J, Nussenzweig A, Deng CX, Finkel T. A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Molecular Cell. 35: 534-41. PMID 19716796 DOI: 10.1016/J.Molcel.2009.06.037  0.461
2009 Murga M, Bunting S, Montaña MF, Soria R, Mulero F, Cañamero M, Lee Y, McKinnon PJ, Nussenzweig A, Fernandez-Capetillo O. A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nature Genetics. 41: 891-8. PMID 19620979 DOI: 10.1038/Ng.420  0.673
2009 Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW. Mechanisms promoting translocations in editing and switching peripheral B cells. Nature. 460: 231-6. PMID 19587764 DOI: 10.1038/Nature08159  0.727
2009 Callén E, Bunting S, Huang CY, Difilippantonio MJ, Wong N, Khor B, Mahowald G, Kruhlak MJ, Ried T, Sleckman BP, Nussenzweig A. Chimeric IgH-TCRalpha/delta translocations in T lymphocytes mediated by RAG. Cell Cycle (Georgetown, Tex.). 8: 2408-12. PMID 19556863 DOI: 10.4161/Cc.8.15.9085  0.744
2009 Callén E, Jankovic M, Wong N, Zha S, Chen HT, Difilippantonio S, Di Virgilio M, Heidkamp G, Alt FW, Nussenzweig A, Nussenzweig M. Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Molecular Cell. 34: 285-97. PMID 19450527 DOI: 10.1016/J.Molcel.2009.04.025  0.815
2009 Kruhlak MJ, Celeste A, Nussenzweig A. Monitoring DNA breaks in optically highlighted chromatin in living cells by laser scanning confocal microscopy. Methods in Molecular Biology (Clifton, N.J.). 523: 125-40. PMID 19381917 DOI: 10.1007/978-1-59745-190-1_9  0.527
2009 Economopoulou M, Langer HF, Celeste A, Orlova VV, Choi EY, Ma M, Vassilopoulos A, Callen E, Deng C, Bassing CH, Boehm M, Nussenzweig A, Chavakis T. Histone H2AX is integral to hypoxia-driven neovascularization. Nature Medicine. 15: 553-8. PMID 19377486 DOI: 10.1038/Nm.1947  0.499
2009 Kim YC, Gerlitz G, Furusawa T, Catez F, Nussenzweig A, Oh KS, Kraemer KH, Shiloh Y, Bustin M. Activation of ATM depends on chromatin interactions occurring before induction of DNA damage. Nature Cell Biology. 11: 92-6. PMID 19079244 DOI: 10.1038/Ncb1817  0.553
2009 Nussenzweig A. Chromatin Responses to DNA damage Biophysical Journal. 96: 543a. DOI: 10.1016/j.bpj.2008.12.2941  0.461
2008 Robbiani DF, Bothmer A, Callen E, Reina-San-Martin B, Dorsett Y, Difilippantonio S, Bolland DJ, Chen HT, Corcoran AE, Nussenzweig A, Nussenzweig MC. AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations. Cell. 135: 1028-38. PMID 19070574 DOI: 10.1016/J.Cell.2008.09.062  0.782
2008 Daniel JA, Pellegrini M, Lee JH, Paull TT, Feigenbaum L, Nussenzweig A. Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo Journal of Cell Biology. 183: 777-783. PMID 19047460 DOI: 10.1083/Jcb.200805154  0.751
2008 Difilippantonio S, Gapud E, Wong N, Huang CY, Mahowald G, Chen HT, Kruhlak MJ, Callen E, Livak F, Nussenzweig MC, Sleckman BP, Nussenzweig A. 53BP1 facilitates long-range DNA end-joining during V(D)J recombination. Nature. 456: 529-33. PMID 18931658 DOI: 10.1038/Nature07476  0.794
2008 Fernandez-Capetillo O, Nussenzweig A. ATM breaks into heterochromatin. Molecular Cell. 31: 303-4. PMID 18691960 DOI: 10.1016/J.Molcel.2008.07.004  0.741
2008 Takizawa M, Tolarová H, Li Z, Dubois W, Lim S, Callen E, Franco S, Mosaico M, Feigenbaum L, Alt FW, Nussenzweig A, Potter M, Casellas R. AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development. The Journal of Experimental Medicine. 205: 1949-57. PMID 18678733 DOI: 10.1084/Jem.20081007  0.46
2008 Schotta G, Sengupta R, Kubicek S, Malin S, Kauer M, Callén E, Celeste A, Pagani M, Opravil S, De La Rosa-Velazquez IA, Espejo A, Bedford MT, Nussenzweig A, Busslinger M, Jenuwein T. A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes & Development. 22: 2048-61. PMID 18676810 DOI: 10.1101/Gad.476008  0.483
2008 Callén E, Nussenzweig MC, Nussenzweig A. Breaking down cell cycle checkpoints and DNA repair during antigen receptor gene assembly. Oncogene. 26: 7759-64. PMID 18066088 DOI: 10.1038/Sj.Onc.1210873  0.595
2007 Nussenzweig A, Nussenzweig MC. A backup DNA repair pathway moves to the forefront. Cell. 131: 223-5. PMID 17956720 DOI: 10.1016/J.Cell.2007.10.005  0.443
2007 Nussenzweig A. Causes and consequences of the DNA damage response. Cell Cycle (Georgetown, Tex.). 6: 2339-40. PMID 17914283 DOI: 10.4161/Cc.6.19.4995  0.61
2007 Difilippantonio S, Nussenzweig A. The NBS1-ATM connection revisited. Cell Cycle (Georgetown, Tex.). 6: 2366-70. PMID 17881893 DOI: 10.4161/Cc.6.19.4758  0.759
2007 Curry JD, Schulz D, Guidos CJ, Danska JS, Nutter L, Nussenzweig A, Schlissel MS. Chromosomal reinsertion of broken RSS ends during T cell development. The Journal of Experimental Medicine. 204: 2293-303. PMID 17785508 DOI: 10.1084/Jem.20070583  0.473
2007 Jankovic M, Nussenzweig A, Nussenzweig MC. Antigen receptor diversification and chromosome translocations. Nature Immunology. 8: 801-8. PMID 17641661 DOI: 10.1038/Ni1498  0.61
2007 Kim JA, Kruhlak M, Dotiwala F, Nussenzweig A, Haber JE. Heterochromatin is refractory to γ-H2AX modification in yeast and mammals Journal of Cell Biology. 178: 209-218. PMID 17635934 DOI: 10.1083/Jcb.200612031  0.574
2007 Callén E, Jankovic M, Difilippantonio S, Daniel JA, Chen HT, Celeste A, Pellegrini M, McBride K, Wangsa D, Bredemeyer AL, Sleckman BP, Ried T, Nussenzweig M, Nussenzweig A. ATM Prevents the Persistence and Propagation of Chromosome Breaks in Lymphocytes Cell. 130: 63-75. PMID 17599403 DOI: 10.1016/J.Cell.2007.06.016  0.837
2007 Downs JA, Nussenzweig MC, Nussenzweig A. Chromatin dynamics and the preservation of genetic information. Nature. 447: 951-8. PMID 17581578 DOI: 10.1038/Nature05980  0.575
2007 Ramiro A, Reina San-Martin B, McBride K, Jankovic M, Barreto V, Nussenzweig A, Nussenzweig MC. The role of activation-induced deaminase in antibody diversification and chromosome translocations. Advances in Immunology. 94: 75-107. PMID 17560272 DOI: 10.1016/S0065-2776(06)94003-6  0.368
2007 Kruhlak M, Crouch EE, Orlov M, Montaño C, Gorski SA, Nussenzweig A, Misteli T, Phair RD, Casellas R. The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks. Nature. 447: 730-4. PMID 17554310 DOI: 10.1038/Nature05842  0.571
2007 Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature. 447: 725-9. PMID 17554309 DOI: 10.1038/Nature05862  0.421
2007 Soutoglou E, Dorn JF, Sengupta K, Jasin M, Nussenzweig A, Ried T, Danuser G, Misteli T. Positional stability of single double-strand breaks in mammalian cells. Nature Cell Biology. 9: 675-82. PMID 17486118 DOI: 10.1038/Ncb1591  0.53
2007 Difilippantonio S, Celeste A, Kruhlak MJ, Lee Y, Difilippantonio MJ, Feigenbaum L, Jackson SP, McKinnon PJ, Nussenzweig A. Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis. The Journal of Experimental Medicine. 204: 1003-11. PMID 17485521 DOI: 10.1084/Jem.20070319  0.843
2007 Kuznetsov S, Pellegrini M, Shuda K, Fernandez-Capetillo O, Liu Y, Martin BK, Burkett S, Southon E, Pati D, Tessarollo L, West SC, Donovan PJ, Nussenzweig A, Sharan SK. RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. The Journal of Cell Biology. 176: 581-92. PMID 17312021 DOI: 10.1083/Jcb.200608130  0.769
2007 Reina-San-Martin B, Chen J, Nussenzweig A, Nussenzweig MC. Enhanced intra-switch region recombination during immunoglobulin class switch recombination in 53BP1-/- B cells. European Journal of Immunology. 37: 235-9. PMID 17183606 DOI: 10.1002/Eji.200636789  0.469
2006 Kruhlak MJ, Celeste A, Nussenzweig A. Spatio-temporal dynamics of chromatin containing DNA breaks. Cell Cycle (Georgetown, Tex.). 5: 1910-2. PMID 16929171 DOI: 10.4161/Cc.5.17.3169  0.601
2006 Ramiro AR, Nussenzweig MC, Nussenzweig A. Switching on chromosomal translocations. Cancer Research. 66: 7837-9. PMID 16912154 DOI: 10.1158/0008-5472.Can-06-0863  0.457
2006 Pellegrini M, Celeste A, Difilippantonio S, Guo R, Wang W, Feigenbaum L, Nussenzweig A. Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo. Nature. 443: 222-5. PMID 16906133 DOI: 10.1038/Nature05112  0.81
2006 Kruhlak MJ, Celeste A, Dellaire G, Fernandez-Capetillo O, Müller WG, McNally JG, Bazett-Jones DP, Nussenzweig A. Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks. The Journal of Cell Biology. 172: 823-34. PMID 16520385 DOI: 10.1083/Jcb.200510015  0.757
2006 Nussenzweig A, Paull T. DNA repair: tails of histones lost. Nature. 439: 406-7. PMID 16437102 DOI: 10.1038/439406A  0.603
2006 Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, Manis JP, van Deursen J, Nussenzweig A, Paull TT, Alt FW, Chen J. MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Molecular Cell. 21: 187-200. PMID 16427009 DOI: 10.1016/J.Molcel.2005.11.025  0.621
2006 Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, Eisenreich TR, Chen J, Dickins RA, Lowe SW, Nussenzweig A, Nussenzweig MC. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature. 440: 105-9. PMID 16400328 DOI: 10.1038/Nature04495  0.802
2005 Ward IM, Difilippantonio S, Minn K, Mueller MD, Molina JR, Yu X, Frisk CS, Ried T, Nussenzweig A, Chen J. 53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice Molecular and Cellular Biology. 25: 10079-10086. PMID 16260621 DOI: 10.1128/Mcb.25.22.10079-10086.2005  0.737
2005 Lan L, Nakajima S, Komatsu K, Nussenzweig A, Shimamoto A, Oshima J, Yasui A. Accumulation of Werner protein at DNA double-strand breaks in human cells. Journal of Cell Science. 118: 4153-62. PMID 16141234 DOI: 10.1242/Jcs.02544  0.603
2005 Dmitrieva NI, Celeste A, Nussenzweig A, Burg MB. Ku86 preserves chromatin integrity in cells adapted to high NaCl. Proceedings of the National Academy of Sciences of the United States of America. 102: 10730-5. PMID 16027367 DOI: 10.1073/Pnas.0504870102  0.599
2005 Difilippantonio S, Celeste A, Fernandez-Capetillo O, Chen HT, Reina San Martin B, Van Laethem F, Yang YP, Petukhova GV, Eckhaus M, Feigenbaum L, Manova K, Kruhlak M, Camerini-Otero RD, Sharan S, Nussenzweig M, ... Nussenzweig A, et al. Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. Nature Cell Biology. 7: 675-85. PMID 15965469 DOI: 10.1038/Ncb1270  0.831
2005 Reina-San-Martin B, Nussenzweig MC, Nussenzweig A, Difilippantonio S. Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1. Proceedings of the National Academy of Sciences of the United States of America. 102: 1590-5. PMID 15668392 DOI: 10.1073/Pnas.0406289102  0.796
2005 Lee AC, Fernandez-Capetillo O, Pisupati V, Jackson SP, Nussenzweig A. Specific association of mouse MDC1/NFBD1 with NBS1 at sites of DNA-damage. Cell Cycle (Georgetown, Tex.). 4: 177-82. PMID 15611643 DOI: 10.4161/Cc.4.1.1354  0.849
2005 Turner JM, Mahadevaiah SK, Fernandez-Capetillo O, Nussenzweig A, Xu X, Deng CX, Burgoyne PS. Silencing of unsynapsed meiotic chromosomes in the mouse. Nature Genetics. 37: 41-7. PMID 15580272 DOI: 10.1038/Ng1484  0.719
2004 Reina-San-Martin B, Chen HT, Nussenzweig A, Nussenzweig MC. ATM is required for efficient recombination between immunoglobulin switch regions. The Journal of Experimental Medicine. 200: 1103-10. PMID 15520243 DOI: 10.1084/Jem.20041162  0.523
2004 Coppola V, Barrick CA, Southon EA, Celeste A, Wang K, Chen B, Haddad el-B, Yin J, Nussenzweig A, Subramaniam A, Tessarollo L. Ablation of TrkA function in the immune system causes B cell abnormalities. Development (Cambridge, England). 131: 5185-95. PMID 15459109 DOI: 10.1242/Dev.01383  0.343
2004 Sengupta S, Robles AI, Linke SP, Sinogeeva NI, Zhang R, Pedeux R, Ward IM, Celeste A, Nussenzweig A, Chen J, Halazonetis TD, Harris CC. Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. The Journal of Cell Biology. 166: 801-13. PMID 15364958 DOI: 10.1083/Jcb.200405128  0.54
2004 Ramiro AR, Jankovic M, Eisenreich T, Difilippantonio S, Chen-Kiang S, Muramatsu M, Honjo T, Nussenzweig A, Nussenzweig MC. AID is required for c-myc/IgH chromosome translocations in vivo. Cell. 118: 431-8. PMID 15315756 DOI: 10.1016/J.Cell.2004.08.006  0.7
2004 Daniel R, Ramcharan J, Rogakou E, Taganov KD, Greger JG, Bonner W, Nussenzweig A, Katz RA, Skalka AM. Histone H2AX is phosphorylated at sites of retroviral DNA integration but is dispensable for postintegration repair. The Journal of Biological Chemistry. 279: 45810-4. PMID 15308627 DOI: 10.1074/Jbc.M407886200  0.609
2004 Fernandez-Capetillo O, Lee A, Nussenzweig M, Nussenzweig A. H2AX: the histone guardian of the genome. Dna Repair. 3: 959-67. PMID 15279782 DOI: 10.1016/J.Dnarep.2004.03.024  0.845
2004 Fernandez-Capetillo O, Nussenzweig A. Aging counts on chromosomes. Nature Genetics. 36: 672-4. PMID 15226747 DOI: 10.1038/Ng0704-672  0.621
2004 Fernandez-Capetillo O, Allis CD, Nussenzweig A. Phosphorylation of histone H2B at DNA double-strand breaks Journal of Experimental Medicine. 199: 1671-1677. PMID 15197225 DOI: 10.1084/Jem.20032247  0.74
2004 Couëdel C, Mills KD, Barchi M, Shen L, Olshen A, Johnson RD, Nussenzweig A, Essers J, Kanaar R, Li GC, Alt FW, Jasin M. Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells. Genes & Development. 18: 1293-304. PMID 15175261 DOI: 10.1101/Gad.1209204  0.575
2004 Ward IM, Reina-San-Martin B, Olaru A, Minn K, Tamada K, Lau JS, Cascalho M, Chen L, Nussenzweig A, Livak F, Nussenzweig MC, Chen J. 53BP1 is required for class switch recombination. The Journal of Cell Biology. 165: 459-64. PMID 15159415 DOI: 10.1083/Jcb.200403021  0.585
2004 Fernandez-Capetillo O, Nussenzweig A. Linking histone deacetylation with the repair of DNA breaks. Proceedings of the National Academy of Sciences of the United States of America. 101: 1427-8. PMID 14757822 DOI: 10.1073/Pnas.0307342101  0.77
2004 Pilch DR, Sedelnikova OA, Redon C, Celeste A, Nussenzweig A, Bonner WM. Characteristics of gamma-H2AX foci at DNA double-strand breaks sites. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 81: 123-9. PMID 12897845 DOI: 10.1139/O03-042  0.541
2003 Fernandez-Capetillo O, Liebe B, Scherthan H, Nussenzweig A. H2AX regulates meiotic telomere clustering. The Journal of Cell Biology. 163: 15-20. PMID 14530383 DOI: 10.1083/Jcb.200305124  0.716
2003 Fernandez-Capetillo O, Celeste A, Nussenzweig A. Focusing on foci: H2AX and the recruitment of DNA-damage response factors. Cell Cycle (Georgetown, Tex.). 2: 426-7. PMID 12963833 DOI: 10.4161/Cc.2.5.509  0.718
2003 Rockwood LD, Nussenzweig A, Janz S. Paradoxical decrease in mutant frequencies and chromosomal rearrangements in a transgenic lacZ reporter gene in Ku80 null mice deficient in DNA double strand break repair Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 529: 51-58. PMID 12943919 DOI: 10.1016/S0027-5107(03)00108-8  0.467
2003 Celeste A, Difilippantonio S, Difilippantonio MJ, Fernandez-Capetillo O, Pilch DR, Sedelnikova OA, Eckhaus M, Ried T, Bonner WM, Nussenzweig A. H2AX haploinsufficiency modifies genomic stability and tumor susceptibility Cell. 114: 371-383. PMID 12914701 DOI: 10.1016/S0092-8674(03)00567-1  0.821
2003 Reina-San-Martin B, Difilippantonio S, Hanitsch L, Masilamani RF, Nussenzweig A, Nussenzweig MC. H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation. The Journal of Experimental Medicine. 197: 1767-78. PMID 12810694 DOI: 10.1084/Jem.20030569  0.747
2003 Celeste A, Fernandez-Capetillo O, Kruhlak MJ, Pilch DR, Staudt DW, Lee A, Bonner RF, Bonner WM, Nussenzweig A. Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nature Cell Biology. 5: 675-9. PMID 12792649 DOI: 10.1038/Ncb1004  0.858
2003 Fernandez-Capetillo O, Mahadevaiah SK, Celeste A, Romanienko PJ, Camerini-Otero RD, Bonner WM, Manova K, Burgoyne P, Nussenzweig A. H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis. Developmental Cell. 4: 497-508. PMID 12689589 DOI: 10.1016/S1534-5807(03)00093-5  0.657
2003 Furuta T, Takemura H, Liao ZY, Aune GJ, Redon C, Sedelnikova OA, Pilch DR, Rogakou EP, Celeste A, Chen HT, Nussenzweig A, Aladjem MI, Bonner WM, Pommier Y. Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes. The Journal of Biological Chemistry. 278: 20303-12. PMID 12660252 DOI: 10.1074/Jbc.M300198200  0.607
2002 Fernandez-Capetillo O, Chen HT, Celeste A, Ward I, Romanienko PJ, Morales JC, Naka K, Xia Z, Camerini-Otero RD, Motoyama N, Carpenter PB, Bonner WM, Chen J, Nussenzweig A. DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nature Cell Biology. 4: 993-7. PMID 12447390 DOI: 10.1038/Ncb884  0.756
2002 Difilippantonio MJ, Petersen S, Chen HT, Johnson R, Jasin M, Kanaar R, Ried T, Nussenzweig A. Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification Journal of Experimental Medicine. 196: 469-480. PMID 12186839 DOI: 10.1084/Jem.20020851  0.793
2002 Ishii KJ, Takeshita F, Gursel I, Gursel M, Conover J, Nussenzweig A, Klinman DM. Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation. The Journal of Experimental Medicine. 196: 269-74. PMID 12119352 DOI: 10.1084/Jem.20020773  0.562
2002 Celeste A, Petersen S, Romanienko PJ, Fernandez-Capetillo O, Chen HT, Sedelnikova OA, Reina-San-Martin B, Coppola V, Meffre E, Difilippantonio MJ, Redon C, Pilch DR, Olaru A, Eckhaus M, Camerini-Otero RD, ... ... Nussenzweig A, et al. Genomic instability in mice lacking histone H2AX. Science (New York, N.Y.). 296: 922-7. PMID 11934988 DOI: 10.1126/Science.1069398  0.846
2001 Petersen S, Casellas R, Reina-San-Martin B, Chen HT, Difilippantonio MJ, Wilson PC, Hanitsch L, Celeste A, Muramatsu M, Pilch DR, Redon C, Ried T, Bonner WM, Honjo T, Nussenzweig MC, ... Nussenzweig A, et al. AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching Nature. 414: 660-665. PMID 11740565 DOI: 10.1038/414660A  0.75
2001 Davodeau F, Difilippantonio M, Roldan E, Malissen M, Casanova JL, Couedel C, Morcet JF, Merkenschlager M, Nussenzweig A, Bonneville M, Malissen B. The tight interallelic positional coincidence that distinguishes T-cell receptor Jalpha usage does not result from homologous chromosomal pairing during ValphaJalpha rearrangement. The Embo Journal. 20: 4717-29. PMID 11532936 DOI: 10.1093/Emboj/20.17.4717  0.659
2001 Sekiguchi J, Ferguson DO, Chen HT, Yang EM, Earle J, Frank K, Whitlow S, Gu Y, Xu Y, Nussenzweig A, Alt FW. Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development. Proceedings of the National Academy of Sciences of the United States of America. 98: 3243-8. PMID 11248063 DOI: 10.1073/Pnas.051632098  0.589
2001 Zhu J, Petersen S, Tessarollo L, Nussenzweig A. Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice. Current Biology : Cb. 11: 105-9. PMID 11231126 DOI: 10.1016/S0960-9822(01)00019-7  0.425
2000 Arrington ED, Caldwell MC, Kumaravel TS, Lohani A, Joshi A, Evans MK, Chen HT, Nussenzweig A, Holbrook NJ, Gorospe M. Enhanced sensitivity and long-term G2 arrest in hydrogen peroxide-treated Ku80-null cells are unrelated to DNA repair defects. Free Radical Biology & Medicine. 29: 1166-76. PMID 11121725 DOI: 10.1016/S0891-5849(00)00439-1  0.527
2000 Chen HT, Bhandoola A, Difilippantonio MJ, Zhu J, Brown MJ, Tai X, Rogakou EP, Brotz TM, Bonner WM, Ried T, Nussenzweig A. Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX. Science (New York, N.Y.). 290: 1962-5. PMID 11110662 DOI: 10.1126/Science.290.5498.1962  0.746
2000 Bhandoola A, Dolnick B, Fayad N, Nussenzweig A, Singer A. Immature thymocytes undergoing receptor rearrangements are resistant to an Atm-dependent death pathway activated in mature T cells by double-stranded DNA breaks. The Journal of Experimental Medicine. 192: 891-7. PMID 10993919 DOI: 10.1084/Jem.192.6.891  0.49
2000 Difilippantonio MJ, Zhu J, Chen HT, Meffre E, Nussenzweig MC, Max EE, Ried T, Nussenzweig A. DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature. 404: 510-4. PMID 10761921 DOI: 10.1038/35006670  0.77
1999 Hurd YL, Yakovleva T, Nussenzweig A, Li GC, Terenius L, Bakalkin G. A novel neuron-specific DNA end-binding factor in the murine brain. Molecular and Cellular Neurosciences. 14: 213-24. PMID 10576891 DOI: 10.1006/Mcne.1999.0782  0.474
1999 Qin XF, Schwers S, Yu W, Papavasiliou F, Suh H, Nussenzweig A, Rajewsky K, Nussenzweig MC. Secondary V(D)J recombination in B-1 cells. Nature. 397: 355-9. PMID 9950428 DOI: 10.1038/16933  0.314
1998 Bakalkin G, Yakovleva T, Hurd YL, Nussenzweig A, Li GC, Terenius L. Autoantigen Ku in the brain. Developmentally regulated expression and subcellular localization. Neuroreport. 9: 2147-51. PMID 9674610 DOI: 10.1097/00001756-199806220-00044  0.335
1998 Casellas R, Nussenzweig A, Wuerffel R, Pelanda R, Reichlin A, Suh H, Qin XF, Besmer E, Kenter A, Rajewsky K, Nussenzweig MC. Ku80 is required for immunoglobulin isotype switching Embo Journal. 17: 2404-2411. PMID 9545251 DOI: 10.1093/Emboj/17.8.2404  0.41
1998 Nussenzweig A, Sokol K, Burgman P, Li L, Li GC. Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development. Proceedings of the National Academy of Sciences of the United States of America. 94: 13588-93. PMID 9391070 DOI: 10.1073/Pnas.94.25.13588  0.536
1997 Ludwig DL, Chen F, Peterson SR, Nussenzweig A, Li GC, Chen DJ. Ku80 gene expression is Sp1-dependent and sensitive to CpG methylation within a novel cis element. Gene. 199: 181-94. PMID 9358055 DOI: 10.1016/S0378-1119(97)00366-1  0.406
1997 Ouyang H, Nussenzweig A, Kurimasa A, Soares VC, Li X, Cordon-Cardo C, Li Wh, Cheong N, Nussenzweig M, Iliakis G, Chen DJ, Li GC. Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo. The Journal of Experimental Medicine. 186: 921-9. PMID 9294146 DOI: 10.1084/Jem.186.6.921  0.57
1996 Cortes P, Weis-Garcia F, Misulovin Z, Nussenzweig A, Lai JS, Li G, Nussenzweig MC, Baltimore D. In vitro V(D)J recombination: Signal joint formation Proceedings of the National Academy of Sciences of the United States of America. 93: 14008-14013. PMID 8943051 DOI: 10.1073/Pnas.93.24.14008  0.325
1996 Nussenzweig A, Chen C, da Costa Soares V, Sanchez M, Sokol K, Nussenzweig MC, Li GC. Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature. 382: 551-5. PMID 8700231 DOI: 10.1038/382551A0  0.591
1996 Yang SH, Nussenzweig A, Li L, Kim D, Ouyang H, Burgman P, Li GC. Modulation of thermal induction of hsp70 expression by Ku autoantigen or its individual subunits. Molecular and Cellular Biology. 16: 3799-806. PMID 8668197 DOI: 10.1128/Mcb.16.7.3799  0.304
1996 Yang S, Nussenzweig A, Yang W, Kim D, Li GC. Cloning and Characterization of Rat Ku70: Involvement of Ku Autoantigen in the Heat-Shock Response Radiation Research. 146: 603. DOI: 10.2307/3579375  0.342
1995 Kim D, Ouyang H, Yang SH, Nussenzweig A, Burgman P, Li GC. A constitutive heat shock element-binding factor is immunologically identical to the Ku autoantigen. The Journal of Biological Chemistry. 270: 15277-84. PMID 7797514 DOI: 10.1074/Jbc.270.25.15277  0.351
1995 Li GC, Yang SH, Kim D, Nussenzweig A, Ouyang H, Wei J, Burgman P, Li L. Suppression of heat-induced hsp70 expression by the 70-kDa subunit of the human Ku autoantigen. Proceedings of the National Academy of Sciences of the United States of America. 92: 4512-6. PMID 7753835 DOI: 10.1073/Pnas.92.10.4512  0.303
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