Kun-Liang Guan, PhD - Publications

Affiliations: 
Pharmacology, Member, Moores Cancer Center University of California, San Diego, La Jolla, CA 
Area:
Molecular Biology, Cell Biology, Genetics & Genealogy
Website:
http://pharmacology.ucsd.edu/faculty/guan.html

133 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Jewell JL, Fu V, Hong AW, Yu FX, Meng D, Melick CH, Wang H, Lam WM, Yuan HX, Taylor SS, Guan KL. GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor. Elife. 8. PMID 31112131 DOI: 10.7554/eLife.43038  0.56
2019 Li L, Guan KL. Correction: Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) is a negative regulator of the mammalian target of rapamycin complex 1 (mTORC1). The Journal of Biological Chemistry. 294: 5810. PMID 30979852 DOI: 10.1074/jbc.AAC119.008438  0.48
2019 Huang W, Lv X, Liu C, Zha Z, Zhang H, Jiang Y, Xiong Y, Lei QY, Guan KL. Correction: The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCF-dependent degradation in response to phosphatidylinositol 3-kinase inhibition. The Journal of Biological Chemistry. 294: 5809. PMID 30979851 DOI: 10.1074/jbc.AAC119.008437  0.64
2019 Zhang H, Liu CY, Zha ZY, Zhao B, Yao J, Zhao S, Xiong Y, Lei QY, Guan KL. Correction: TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. The Journal of Biological Chemistry. 294: 5808. PMID 30979850 DOI: 10.1074/jbc.AAC119.008436  1
2019 Li Y, Inoki K, Vacratsis P, Guan KL. Correction: The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3. The Journal of Biological Chemistry. 294: 5807. PMID 30979849 DOI: 10.1074/jbc.AAC119.008435  0.4
2019 Tang H, Inoki K, Brooks SV, Okazawa H, Lee M, Wang J, Kim M, Kennedy CL, Macpherson PCD, Ji X, Van Roekel S, Fraga DA, Wang K, Zhu J, Wang Y, ... ... Guan KL, et al. mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism. Aging Cell. e12943. PMID 30924297 DOI: 10.1111/acel.12943  0.4
2018 Meng Z, Qiu Y, Lin KC, Kumar A, Placone JK, Fang C, Wang KC, Lu S, Pan M, Hong AW, Moroishi T, Luo M, Plouffe SW, Diao Y, Ye Z, ... ... Guan KL, et al. RAP2 mediates mechanoresponses of the Hippo pathway. Nature. PMID 30135582 DOI: 10.1038/s41586-018-0444-0  0.56
2018 Akgül S, Li Y, Zheng S, Kool M, Treisman DM, Li C, Wang Y, Gröbner S, Ikenoue T, Shen Y, Camelo-Piragua S, Tomasek G, Stark S, Guduguntla V, Gusella JF, ... Guan KL, et al. Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma. Cell Reports. 24: 463-478.e5. PMID 29996106 DOI: 10.1016/j.celrep.2018.06.050  0.4
2017 Jin Y, Chen Y, Zhao S, Guan KL, Zhuang Y, Zhou W, Wu X, Xu T. DNA-PK facilitates piggyBac transposition by promoting paired-end complex formation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28645898 DOI: 10.1073/pnas.1612980114  0.36
2017 Zhang Q, Meng F, Chen S, Plouffe SW, Wu S, Liu S, Li X, Zhou R, Wang J, Zhao B, Liu J, Qin J, Zou J, Feng XH, Guan KL, et al. Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade. Nature Cell Biology. PMID 28346439 DOI: 10.1038/ncb3496  1
2017 Ma S, Sun R, Jiang B, Gao J, Deng W, Liu P, He R, Cui J, Ji M, Yi W, Yang P, Wu X, Xiong Y, Qiu Z, Ye D, ... Guan KL, et al. L2hgdh deficiency accumulates L-2-hydroxyglutarate with progressive leukoencephalopathy and neurodegeneration. Molecular and Cellular Biology. PMID 28137912 DOI: 10.1128/MCB.00492-16  0.36
2016 Wang KC, Yeh YT, Nguyen P, Limqueco E, Lopez J, Thorossian S, Guan KL, Li YJ, Chien S. Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 27671657 DOI: 10.1073/pnas.1613121113  1
2016 Zha Z, Han XR, Smith MD, Lei QY, Guan KL, Xiong Y. Hypertension-associated C825T polymorphism impairs the function of Gβ3 to target GRK2 ubiquitination. Cell Discovery. 2: 16005. PMID 27462452 DOI: 10.1038/celldisc.2016.5  0.64
2016 Feng X, Liu P, Zhou X, Li MT, Li FL, Wang Z, Meng ZP, Sun YP, Yu Y, Xiong Y, Yuan HX, Guan KL. Thromboxane A2 Activates YAP/TAZ to Induce Vascular Smooth Muscle Cell Proliferation and Migration. The Journal of Biological Chemistry. PMID 27382053 DOI: 10.1074/jbc.M116.739722  1
2016 Hong AW, Meng Z, Guan KL. The Hippo pathway in intestinal regeneration and disease. Nature Reviews. Gastroenterology & Hepatology. PMID 27147489 DOI: 10.1038/nrgastro.2016.59  1
2016 Meng F, Zhou R, Wu S, Zhang Q, Jin Q, Zhou Y, Plouffe SW, Liu S, Song H, Xia Z, Zhao B, Ye S, Feng XH, Guan KL, Zou J, et al. Mst1 shuts off cytosolic antiviral defense through IRF3 phosphorylation. Genes & Development. PMID 27125670 DOI: 10.1101/gad.277533.116  1
2016 Zhou L, Wang F, Sun R, Chen X, Zhang M, Xu Q, Wang Y, Wang S, Xiong Y, Guan KL, Yang P, Yu H, Ye D. SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense. Embo Reports. PMID 27113762 DOI: 10.15252/embr.201541643  1
2016 Fu V, Moroishi T, Guan KL. Glycoholics Anonymous: Cancer Sobers Up with mTORC1. Cancer Cell. 29: 432-4. PMID 27070696 DOI: 10.1016/j.ccell.2016.03.016  1
2016 Meng Z, Moroishi T, Guan KL. Mechanisms of Hippo pathway regulation. Genes & Development. 30: 1-17. PMID 26728553 DOI: 10.1101/gad.274027.115  1
2015 Lyubasyuk V, Ouyang H, Yu FX, Guan KL, Zhang K. YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations. Molecular & Cellular Oncology. 2: e970957. PMID 27308390 DOI: 10.4161/23723548.2014.970957  0.56
2015 Wang P, Wu J, Ma S, Zhang L, Yao J, Hoadley KA, Wilkerson MD, Perou CM, Guan KL, Ye D, Xiong Y. Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. Cell Reports. PMID 26686626 DOI: 10.1016/j.celrep.2015.11.029  1
2015 Yuan HX, Wang Z, Yu FX, Li F, Russell RC, Jewell JL, Guan KL. NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition. Genes & Development. 29: 2362-76. PMID 26588989 DOI: 10.1101/gad.265116.115  1
2015 Yu FX, Zhao B, Guan KL. Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. Cell. 163: 811-28. PMID 26544935 DOI: 10.1016/j.cell.2015.10.044  1
2015 Wang S, Jiang B, Zhang T, Liu L, Wang Y, Wang Y, Chen X, Lin H, Zhou L, Xia Y, Chen L, Yang C, Xiong Y, Ye D, Guan KL. Correction: Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1. Plos Biology. 13: e1002287. PMID 26539968 DOI: 10.1371/journal.pbio.1002287  1
2015 Yuan HX, Guan KL. The SIN1-PH Domain Connects mTORC2 to PI3K. Cancer Discovery. 5: 1127-9. PMID 26526694 DOI: 10.1158/2159-8290.CD-15-1125  1
2015 Meng Z, Moroishi T, Mottier-Pavie V, Plouffe SW, Hansen CG, Hong AW, Park HW, Mo JS, Lu W, Lu S, Flores F, Yu FX, Halder G, Guan KL. MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nature Communications. 6: 8357. PMID 26437443 DOI: 10.1038/ncomms9357  1
2015 Nemazanyy I, Montagnac G, Russell RC, Morzyglod L, Burnol AF, Guan KL, Pende M, Panasyuk G. Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. Nature Communications. 6: 8283. PMID 26387534 DOI: 10.1038/ncomms9283  1
2015 Wang S, Jiang B, Zhang T, Liu L, Wang Y, Wang Y, Chen X, Lin H, Zhou L, Xia Y, Chen L, Yang C, Xiong Y, Ye D, Guan KL. Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1. Plos Biology. 13: e1002243. PMID 26356530 DOI: 10.1371/journal.pbio.1002243  1
2015 Ha J, Guan KL, Kim J. AMPK and autophagy in glucose/glycogen metabolism. Molecular Aspects of Medicine. PMID 26297963 DOI: 10.1016/j.mam.2015.08.002  1
2015 Park HW, Kim YC, Yu B, Moroishi T, Mo JS, Plouffe SW, Meng Z, Lin KC, Yu FX, Alexander CM, Wang CY, Guan KL. Alternative Wnt Signaling Activates YAP/TAZ. Cell. 162: 780-94. PMID 26276632 DOI: 10.1016/j.cell.2015.07.013  1
2015 Gong R, Hong AW, Plouffe SW, Zhao B, Liu G, Yu FX, Xu Y, Guan KL. Opposing roles of conventional and novel PKC isoforms in Hippo-YAP pathway regulation. Cell Research. PMID 26206313 DOI: 10.1038/cr.2015.88  1
2015 Lv XB, Liu CY, Wang Z, Sun YP, Xiong Y, Lei QY, Guan KL. PARD3 induces TAZ activation and cell growth by promoting LATS1 and PP1 interaction. Embo Reports. PMID 26116754 DOI: 10.15252/embr.201439951  1
2015 Moroishi T, Park HW, Qin B, Chen Q, Meng Z, Plouffe SW, Taniguchi K, Yu FX, Karin M, Pan D, Guan KL. A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis. Genes & Development. 29: 1271-84. PMID 26109050 DOI: 10.1101/gad.262816.115  1
2015 Hansen CG, Moroishi T, Guan KL. YAP and TAZ: a nexus for Hippo signaling and beyond. Trends in Cell Biology. PMID 26045258 DOI: 10.1016/j.tcb.2015.05.002  1
2015 Qi Q, Li DY, Luo HR, Guan KL, Ye K. Netrin-1 exerts oncogenic activities through enhancing Yes-associated protein stability. Proceedings of the National Academy of Sciences of the United States of America. 112: 7255-60. PMID 26039999 DOI: 10.1073/pnas.1505917112  1
2015 Zha Z, Han X, Smith MD, Liu Y, Giguère PM, Kopanja D, Raychaudhuri P, Siderovski DP, Guan KL, Lei QY, Xiong Y. A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation. Molecular Cell. 58: 794-803. PMID 25982117 DOI: 10.1016/j.molcel.2015.04.017  1
2015 Zhou X, Wang S, Wang Z, Feng X, Liu P, Lv XB, Li F, Yu FX, Sun Y, Yuan H, Zhu H, Xiong Y, Lei QY, Guan KL. Estrogen regulates Hippo signaling via GPER in breast cancer. The Journal of Clinical Investigation. 125: 2123-35. PMID 25893606 DOI: 10.1172/JCI79573  1
2015 Zhou Q, Li L, Zhao B, Guan KL. The hippo pathway in heart development, regeneration, and diseases. Circulation Research. 116: 1431-47. PMID 25858067 DOI: 10.1161/CIRCRESAHA.116.303311  1
2015 Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, ... ... Guan KL, et al. A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature. 519: 57-62. PMID 25731159 DOI: 10.1038/nature14228  0.56
2015 Plouffe SW, Hong AW, Guan KL. Disease implications of the Hippo/YAP pathway. Trends in Molecular Medicine. 21: 212-22. PMID 25702974 DOI: 10.1016/j.molmed.2015.01.003  1
2015 Jewell JL, Flores F, Guan KL. Micro(RNA) managing by mTORC1. Molecular Cell. 57: 575-6. PMID 25699705 DOI: 10.1016/j.molcel.2015.02.006  1
2015 Kim YC, Guan KL. mTOR: a pharmacologic target for autophagy regulation. The Journal of Clinical Investigation. 125: 25-32. PMID 25654547 DOI: 10.1172/JCI73939  1
2015 Jewell JL, Kim YC, Russell RC, Yu FX, Park HW, Plouffe SW, Tagliabracci VS, Guan KL. Metabolism. Differential regulation of mTORC1 by leucine and glutamine. Science (New York, N.Y.). 347: 194-8. PMID 25567907 DOI: 10.1126/science.1259472  1
2015 Yu FX, Meng Z, Plouffe SW, Guan KL. Hippo pathway regulation of gastrointestinal tissues. Annual Review of Physiology. 77: 201-27. PMID 25293527 DOI: 10.1146/annurev-physiol-021014-071733  1
2015 Liu G, Yu FX, Kim YC, Meng Z, Naipauer J, Looney DJ, Liu X, Gutkind JS, Mesri EA, Guan KL. Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway. Oncogene. 34: 3536-46. PMID 25195862 DOI: 10.1038/onc.2014.281  0.56
2014 Yu FX, Zhang K, Guan KL. YAP as oncotarget in uveal melanoma. Oncoscience. 1: 480-1. PMID 25594048  0.56
2014 Parmigiani A, Nourbakhsh A, Ding B, Wang W, Kim YC, Akopiants K, Guan KL, Karin M, Budanov AV. Sestrins inhibit mTORC1 kinase activation through the GATOR complex. Cell Reports. 9: 1281-91. PMID 25457612 DOI: 10.1016/j.celrep.2014.10.019  1
2014 Zhao D, Mo Y, Li MT, Zou SW, Cheng ZL, Sun YP, Xiong Y, Guan KL, Lei QY. NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. The Journal of Clinical Investigation. 124: 5453-65. PMID 25384215 DOI: 10.1172/JCI76611  0.64
2014 Zhao B, Guan KL. Hippo pathway key to ploidy checkpoint. Cell. 158: 695-6. PMID 25126776 DOI: 10.1016/j.cell.2014.07.041  1
2014 Kim YC, Park HW, Sciarretta S, Mo JS, Jewell JL, Russell RC, Wu X, Sadoshima J, Guan KL. Rag GTPases are cardioprotective by regulating lysosomal function. Nature Communications. 5: 4241. PMID 24980141 DOI: 10.1038/ncomms5241  1
2014 Yu FX, Luo J, Mo JS, Liu G, Kim YC, Meng Z, Zhao L, Peyman G, Ouyang H, Jiang W, Zhao J, Chen X, Zhang L, Wang CY, Bastian BC, ... ... Guan KL, et al. Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Cancer Cell. 25: 822-30. PMID 24882516 DOI: 10.1016/j.ccr.2014.04.017  1
2014 Xu Y, Li F, Lv L, Li T, Zhou X, Deng CX, Guan KL, Lei QY, Xiong Y. Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase. Cancer Research. 74: 3630-42. PMID 24786789 DOI: 10.1158/0008-5472.CAN-13-3615  0.64
2014 Wang YP, Zhou LS, Zhao YZ, Wang SW, Chen LL, Liu LX, Ling ZQ, Hu FJ, Sun YP, Zhang JY, Yang C, Yang Y, Xiong Y, Guan KL, Ye D. Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress. The Embo Journal. 33: 1304-20. PMID 24769394 DOI: 10.1002/embj.201387224  1
2014 Wang P, Zhou Z, Hu A, Ponte de Albuquerque C, Zhou Y, Hong L, Sierecki E, Ajiro M, Kruhlak M, Harris C, Guan KL, Zheng ZM, Newton AC, Sun P, Zhou H, et al. Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt. Molecular Cell. 54: 378-91. PMID 24703948 DOI: 10.1016/j.molcel.2014.03.007  1
2014 Yu FX, Guan KL. Transcription and processing: multilayer controls of RNA biogenesis by the Hippo pathway. The Embo Journal. 33: 942-4. PMID 24639555 DOI: 10.1002/embj.201488329  1
2014 Tang H, Inoki K, Lee M, Wright E, Khuong A, Khuong A, Sugiarto S, Garner M, Paik J, DePinho RA, Goldman D, Guan KL, Shrager JB. mTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation of FoxO and E3 ubiquitin ligases. Science Signaling. 7: ra18. PMID 24570486 DOI: 10.1126/scisignal.2004809  1
2014 Li T, Liu M, Feng X, Wang Z, Das I, Xu Y, Zhou X, Sun Y, Guan KL, Xiong Y, Lei QY. Glyceraldehyde-3-phosphate dehydrogenase is activated by lysine 254 acetylation in response to glucose signal. The Journal of Biological Chemistry. 289: 3775-85. PMID 24362262 DOI: 10.1074/jbc.M113.531640  0.64
2014 Lin R, Zhou X, Huang W, Zhao D, Lv L, Xiong Y, Guan KL, Lei QY. Acetylation control of cancer cell metabolism. Current Pharmaceutical Design. 20: 2627-33. PMID 23859620  0.64
2013 Li J, Chen X, Ding X, Cheng Y, Zhao B, Lai ZC, Al Hezaimi K, Hakem R, Guan KL, Wang CY. LATS2 suppresses oncogenic Wnt signaling by disrupting β-catenin/BCL9 interaction. Cell Reports. 5: 1650-63. PMID 24360964 DOI: 10.1016/j.celrep.2013.11.037  1
2013 Lv L, Xu YP, Zhao D, Li FL, Wang W, Sasaki N, Jiang Y, Zhou X, Li TT, Guan KL, Lei QY, Xiong Y. Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization. Molecular Cell. 52: 340-52. PMID 24120661 DOI: 10.1016/j.molcel.2013.09.004  0.64
2013 Dai X, She P, Chi F, Feng Y, Liu H, Jin D, Zhao Y, Guo X, Jiang D, Guan KL, Zhong TP, Zhao B. Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration, and angiogenesis. The Journal of Biological Chemistry. 288: 34041-51. PMID 24106267 DOI: 10.1074/jbc.M113.518019  1
2013 Park HW, Guan KL. Regulation of the Hippo pathway and implications for anticancer drug development. Trends in Pharmacological Sciences. 34: 581-9. PMID 24051213 DOI: 10.1016/j.tips.2013.08.006  1
2013 Lin R, Tao R, Gao X, Li T, Zhou X, Guan KL, Xiong Y, Lei QY. Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth. Molecular Cell. 51: 506-18. PMID 23932781 DOI: 10.1016/j.molcel.2013.07.002  0.64
2013 Zhao D, Xiong Y, Lei QY, Guan KL. LDH-A acetylation: implication in cancer. Oncotarget. 4: 802-3. PMID 23868819  0.64
2013 Yu FX, Zhang Y, Park HW, Jewell JL, Chen Q, Deng Y, Pan D, Taylor SS, Lai ZC, Guan KL. Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation. Genes & Development. 27: 1223-32. PMID 23752589 DOI: 10.1101/gad.219402.113  1
2013 Russell RC, Tian Y, Yuan H, Park HW, Chang YY, Kim J, Kim H, Neufeld TP, Dillin A, Guan KL. ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nature Cell Biology. 15: 741-50. PMID 23685627 DOI: 10.1038/ncb2757  1
2013 Kim J, Guan KL. AMPK connects energy stress to PIK3C3/VPS34 regulation. Autophagy. 9: 1110-1. PMID 23669030 DOI: 10.4161/auto.24877  1
2013 Zhao D, Xiong Y, Lei QY, Guan KL. LDH-A Acetylation: implication in Pancreatic Cancer Initiation and Diagnosis. Oncotarget. PMID 23633471  0.64
2013 Zhao D, Zou SW, Liu Y, Zhou X, Mo Y, Wang P, Xu YH, Dong B, Xiong Y, Lei QY, Guan KL. Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer. Cancer Cell. 23: 464-76. PMID 23523103 DOI: 10.1016/j.ccr.2013.02.005  0.64
2013 Jewell JL, Guan KL. Nutrient signaling to mTOR and cell growth. Trends in Biochemical Sciences. 38: 233-42. PMID 23465396 DOI: 10.1016/j.tibs.2013.01.004  1
2013 Yu FX, Guan KL. The Hippo pathway: regulators and regulations. Genes & Development. 27: 355-71. PMID 23431053 DOI: 10.1101/gad.210773.112  1
2013 Jewell JL, Russell RC, Guan KL. Amino acid signalling upstream of mTOR. Nature Reviews. Molecular Cell Biology. 14: 133-9. PMID 23361334 DOI: 10.1038/nrm3522  1
2013 Li L, Guan KL. Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) is a negative regulator of the mammalian target of rapamycin complex 1 (mTORC1). The Journal of Biological Chemistry. 288: 703-8. PMID 23184942 DOI: 10.1074/jbc.C112.396903  1
2013 Wang P, Dong Q, Zhang C, Kuan PF, Liu Y, Jeck WR, Andersen JB, Jiang W, Savich GL, Tan TX, Auman JT, Hoskins JM, Misher AD, Moser CD, Yourstone SM, ... ... Guan KL, et al. Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas. Oncogene. 32: 3091-100. PMID 22824796 DOI: 10.1038/onc.2012.315  1
2012 Tumaneng K, Schlegelmilch K, Russell RC, Yimlamai D, Basnet H, Mahadevan N, Fitamant J, Bardeesy N, Camargo FD, Guan KL. YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29. Nature Cell Biology. 14: 1322-9. PMID 23143395 DOI: 10.1038/ncb2615  0.76
2012 Yu FX, Mo JS, Guan KL. Upstream regulators of the Hippo pathway. Cell Cycle (Georgetown, Tex.). 11: 4097-8. PMID 23075495 DOI: 10.4161/cc.22322  0.56
2012 Mo JS, Yu FX, Gong R, Brown JH, Guan KL. Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs). Genes & Development. 26: 2138-43. PMID 22972936 DOI: 10.1101/gad.197582.112  1
2012 Magee JA, Ikenoue T, Nakada D, Lee JY, Guan KL, Morrison SJ. Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression. Cell Stem Cell. 11: 415-28. PMID 22958933 DOI: 10.1016/j.stem.2012.05.026  1
2012 Yu FX, Zhao B, Panupinthu N, Jewell JL, Lian I, Wang LH, Zhao J, Yuan H, Tumaneng K, Li H, Fu XD, Mills GB, Guan KL. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell. 150: 780-91. PMID 22863277 DOI: 10.1016/j.cell.2012.06.037  1
2012 Tang F, Wu Q, Ikenoue T, Guan KL, Liu Y, Zheng P. A critical role for Rictor in T lymphopoiesis. Journal of Immunology (Baltimore, Md. : 1950). 189: 1850-7. PMID 22815285 DOI: 10.4049/jimmunol.1201057  0.4
2012 Huang W, Lv X, Liu C, Zha Z, Zhang H, Jiang Y, Xiong Y, Lei QY, Guan KL. The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFβ-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibition. The Journal of Biological Chemistry. 287: 26245-53. PMID 22692215 DOI: 10.1074/jbc.M112.382036  0.64
2012 Purohit AA, Li W, Qu C, Dwyer T, Shao Q, Guan KL, Liu G. Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse. The Journal of Biological Chemistry. 287: 27126-38. PMID 22685302 DOI: 10.1074/jbc.M112.340174  1
2012 Tumaneng K, Russell RC, Guan KL. Organ size control by Hippo and TOR pathways. Current Biology : Cb. 22: R368-79. PMID 22575479 DOI: 10.1016/j.cub.2012.03.003  0.76
2012 Valbuena N, Guan KL, Moreno S. The Vam6 and Gtr1-Gtr2 pathway activates TORC1 in response to amino acids in fission yeast. Journal of Cell Science. 125: 1920-8. PMID 22344254 DOI: 10.1242/jcs.094219  1
2012 Zhao B, Li L, Wang L, Wang CY, Yu J, Guan KL. Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis. Genes & Development. 26: 54-68. PMID 22215811 DOI: 10.1101/gad.173435.111  1
2012 Mori H, Guan KL. Tissue-specific ablation of Tsc1 in pancreatic beta-cells. Methods in Molecular Biology (Clifton, N.J.). 821: 407-19. PMID 22125081 DOI: 10.1007/978-1-61779-430-8_26  1
2012 Inoki K, Kim J, Guan KL. AMPK and mTOR in cellular energy homeostasis and drug targets. Annual Review of Pharmacology and Toxicology. 52: 381-400. PMID 22017684 DOI: 10.1146/annurev-pharmtox-010611-134537  0.4
2012 Zhou X, Li TT, Feng X, Hsiang E, Xiong Y, Guan KL, Lei QY. Targeted polyubiquitylation of RASSF1C by the Mule and SCFβ-TrCP ligases in response to DNA damage. The Biochemical Journal. 441: 227-36. PMID 21910689 DOI: 10.1042/BJ20111500  0.64
2011 Xiong Y, Lei QY, Zhao S, Guan KL. Regulation of glycolysis and gluconeogenesis by acetylation of PKM and PEPCK. Cold Spring Harbor Symposia On Quantitative Biology. 76: 285-9. PMID 22096030 DOI: 10.1101/sqb.2011.76.010942  0.64
2011 Gong R, Li L, Liu Y, Wang P, Yang H, Wang L, Cheng J, Guan KL, Xu Y. Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation. Genes & Development. 25: 1668-73. PMID 21816923 DOI: 10.1101/gad.16968011  0.48
2011 Zhao B, Tumaneng K, Guan KL. The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. Nature Cell Biology. 13: 877-83. PMID 21808241 DOI: 10.1038/ncb2303  1
2011 Yoshida S, Hong S, Suzuki T, Nada S, Mannan AM, Wang J, Okada M, Guan KL, Inoki K. Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway. The Journal of Biological Chemistry. 286: 32651-60. PMID 21784859 DOI: 10.1074/jbc.M111.238014  0.4
2011 Jiang W, Wang S, Xiao M, Lin Y, Zhou L, Lei Q, Xiong Y, Guan KL, Zhao S. Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. Molecular Cell. 43: 33-44. PMID 21726808 DOI: 10.1016/j.molcel.2011.04.028  0.52
2011 Wu Q, Liu Y, Chen C, Ikenoue T, Qiao Y, Li CS, Li W, Guan KL, Liu Y, Zheng P. The tuberous sclerosis complex-mammalian target of rapamycin pathway maintains the quiescence and survival of naive T cells. Journal of Immunology (Baltimore, Md. : 1950). 187: 1106-12. PMID 21709159 DOI: 10.4049/jimmunol.1003968  0.4
2011 Lv L, Li D, Zhao D, Lin R, Chu Y, Zhang H, Zha Z, Liu Y, Li Z, Xu Y, Wang G, Huang Y, Xiong Y, Guan KL, Lei QY. Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Molecular Cell. 42: 719-30. PMID 21700219 DOI: 10.1016/j.molcel.2011.04.025  0.64
2011 Inoki K, Mori H, Wang J, Suzuki T, Hong S, Yoshida S, Blattner SM, Ikenoue T, Rüegg MA, Hall MN, Kwiatkowski DJ, Rastaldi MP, Huber TB, Kretzler M, Holzman LB, ... ... Guan KL, et al. mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice. The Journal of Clinical Investigation. 121: 2181-96. PMID 21606597 DOI: 10.1172/JCI44771  1
2011 Chen Y, Zhang J, Lin Y, Lei Q, Guan KL, Zhao S, Xiong Y. Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS. Embo Reports. 12: 534-41. PMID 21566644 DOI: 10.1038/embor.2011.65  0.52
2011 Kim J, Guan KL. Amino acid signaling in TOR activation. Annual Review of Biochemistry. 80: 1001-32. PMID 21548787 DOI: 10.1146/annurev-biochem-062209-094414  1
2011 Xie X, Zhang D, Zhao B, Lu MK, You M, Condorelli G, Wang CY, Guan KL. IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 108: 6474-9. PMID 21464307 DOI: 10.1073/pnas.1016132108  1
2011 Kim J, Guan KL. Regulation of the autophagy initiating kinase ULK1 by nutrients: roles of mTORC1 and AMPK. Cell Cycle (Georgetown, Tex.). 10: 1337-8. PMID 21403467 DOI: 10.4161/cc.10.9.15291  1
2011 Xie X, Guan KL. The ribosome and TORC2: collaborators for cell growth. Cell. 144: 640-2. PMID 21376227 DOI: 10.1016/j.cell.2011.02.029  1
2011 Zheng M, Wang YH, Wu XN, Wu SQ, Lu BJ, Dong MQ, Zhang H, Sun P, Lin SC, Guan KL, Han J. Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nature Cell Biology. 13: 263-72. PMID 21336308 DOI: 10.1038/ncb2168  1
2011 Hallows WC, Yu W, Smith BC, Devries MK, Devires MK, Ellinger JJ, Someya S, Shortreed MR, Prolla T, Markley JL, Smith LM, Zhao S, Guan KL, Denu JM. Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Molecular Cell. 41: 139-49. PMID 21255725 DOI: 10.1016/j.molcel.2011.01.002  1
2011 Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH, Ito S, Yang C, Wang P, Xiao MT, Liu LX, Jiang WQ, Liu J, Zhang JY, Wang B, ... ... Guan KL, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 19: 17-30. PMID 21251613 DOI: 10.1016/j.ccr.2010.12.014  0.64
2011 Zhao B, Li L, Lu Q, Wang LH, Liu CY, Lei Q, Guan KL. Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes & Development. 25: 51-63. PMID 21205866 DOI: 10.1101/gad.2000111  1
2011 Liu CY, Lv X, Li T, Xu Y, Zhou X, Zhao S, Xiong Y, Lei QY, Guan KL. PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ. The Journal of Biological Chemistry. 286: 5558-66. PMID 21189257 DOI: 10.1074/jbc.M110.194019  0.64
2010 Zhao B, Li L, Guan KL. Hippo signaling at a glance. Journal of Cell Science. 123: 4001-6. PMID 21084559 DOI: 10.1242/jcs.069070  1
2010 Zhao S, Guan KL. IDH1 mutant structures reveal a mechanism of dominant inhibition. Cell Research. 20: 1279-81. PMID 21079649 DOI: 10.1038/cr.2010.160  1
2010 Liu CY, Zha ZY, Zhou X, Zhang H, Huang W, Zhao D, Li T, Chan SW, Lim CJ, Hong W, Zhao S, Xiong Y, Lei QY, Guan KL. The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase. The Journal of Biological Chemistry. 285: 37159-69. PMID 20858893 DOI: 10.1074/jbc.M110.152942  0.64
2010 Zhang D, Contu R, Latronico MV, Zhang J, Zhang JL, Rizzi R, Catalucci D, Miyamoto S, Huang K, Ceci M, Gu Y, Dalton ND, Peterson KL, Guan KL, Brown JH, et al. MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. The Journal of Clinical Investigation. 120: 2805-16. PMID 20644257 DOI: 10.1172/JCI43008  1
2010 Lian I, Kim J, Okazawa H, Zhao J, Zhao B, Yu J, Chinnaiyan A, Israel MA, Goldstein LS, Abujarour R, Ding S, Guan KL. The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes & Development. 24: 1106-18. PMID 20516196 DOI: 10.1101/gad.1903310  1
2010 Zhao B, Li L, Lei Q, Guan KL. The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. Genes & Development. 24: 862-74. PMID 20439427 DOI: 10.1101/gad.1909210  1
2010 Li Z, Zhao B, Wang P, Chen F, Dong Z, Yang H, Guan KL, Xu Y. Structural insights into the YAP and TEAD complex. Genes & Development. 24: 235-40. PMID 20123905 DOI: 10.1101/gad.1865810  1
2010 Zhao B, Li L, Tumaneng K, Wang CY, Guan KL. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). Genes & Development. 24: 72-85. PMID 20048001 DOI: 10.1101/gad.1843810  1
2009 Zhao B, Lei Q, Guan KL. Mst out and HCC in. Cancer Cell. 16: 363-4. PMID 19878866 DOI: 10.1016/j.ccr.2009.10.008  1
2009 Zhang H, Liu CY, Zha ZY, Zhao B, Yao J, Zhao S, Xiong Y, Lei QY, Guan KL. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. The Journal of Biological Chemistry. 284: 13355-62. PMID 19324877 DOI: 10.1074/jbc.M900843200  1
2009 Zhao B, Lei QY, Guan KL. Harness the power: new insights into the inhibition of YAP/Yorkie. Developmental Cell. 16: 321-2. PMID 19289076 DOI: 10.1016/j.devcel.2009.02.015  1
2009 Zhao B, Kim J, Ye X, Lai ZC, Guan KL. Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein. Cancer Research. 69: 1089-98. PMID 19141641 DOI: 10.1158/0008-5472.CAN-08-2997  1
2008 Zhao B, Lei QY, Guan KL. The Hippo-YAP pathway: new connections between regulation of organ size and cancer. Current Opinion in Cell Biology. 20: 638-46. PMID 18955139 DOI: 10.1016/j.ceb.2008.10.001  1
2008 Ikenoue T, Inoki K, Zhao B, Guan KL. PTEN acetylation modulates its interaction with PDZ domain. Cancer Research. 68: 6908-12. PMID 18757404 DOI: 10.1158/0008-5472.CAN-08-1107  1
2008 Zhao B, Ye X, Yu J, Li L, Li W, Li S, Yu J, Lin JD, Wang CY, Chinnaiyan AM, Lai ZC, Guan KL. TEAD mediates YAP-dependent gene induction and growth control. Genes & Development. 22: 1962-71. PMID 18579750 DOI: 10.1101/gad.1664408  1
2008 Lei QY, Zhang H, Zhao B, Zha ZY, Bai F, Pei XH, Zhao S, Xiong Y, Guan KL. TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. Molecular and Cellular Biology. 28: 2426-36. PMID 18227151 DOI: 10.1128/MCB.01874-07  1
2007 Zhao B, Wei X, Li W, Udan RS, Yang Q, Kim J, Xie J, Ikenoue T, Yu J, Li L, Zheng P, Ye K, Chinnaiyan A, Halder G, Lai ZC, ... Guan KL, et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes & Development. 21: 2747-61. PMID 17974916 DOI: 10.1101/gad.1602907  1
1996 Wu X, Noh SJ, Zhou G, Dixon JE, Guan KL. Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells. The Journal of Biological Chemistry. 271: 3265-71. PMID 8621729  1
1993 Guan KL, Dixon JE. Bacterial and viral protein tyrosine phosphatases. Seminars in Cell Biology. 4: 389-96. PMID 8305677  1
1992 Millar JB, Russell P, Dixon JE, Guan KL. Negative regulation of mitosis by two functionally overlapping PTPases in fission yeast. The Embo Journal. 11: 4943-52. PMID 1464319  1
1991 Guan KL, Dixon JE. Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase. Analytical Biochemistry. 192: 262-7. PMID 1852137 DOI: 10.1016/0003-2697(91)90534-Z  1
1991 Guan KL, Broyles SS, Dixon JE. A Tyr/Ser protein phosphatase encoded by vaccinia virus. Nature. 350: 359-62. PMID 1848923 DOI: 10.1038/350359a0  1
1991 Bliska JB, Guan KL, Dixon JE, Falkow S. Tyrosine phosphate hydrolysis of host proteins by an essential Yersinia virulence determinant. Proceedings of the National Academy of Sciences of the United States of America. 88: 1187-91. PMID 1705028  1
1991 Guan KL, Dixon JE. Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediate. The Journal of Biological Chemistry. 266: 17026-30. PMID 1654322  1
1991 Guan KL, Deschenes RJ, Qiu H, Dixon JE. Cloning and expression of a yeast protein tyrosine phosphatase. The Journal of Biological Chemistry. 266: 12964-70. PMID 1649172  1
1990 Guan KL, Dixon JE. Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia. Science (New York, N.Y.). 249: 553-6. PMID 2166336  1
1990 Guan KL, Haun RS, Watson SJ, Geahlen RL, Dixon JE. Cloning and expression of a protein-tyrosine-phosphatase. Proceedings of the National Academy of Sciences of the United States of America. 87: 1501-5. PMID 2154749  1
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