| Year |
Citation |
Score |
| 2022 |
Hu M, Bao R, Lin M, Han XR, Ai YJ, Gao Y, Guan KL, Xiong Y, Yuan HX. ALK fusion promotes metabolic reprogramming of cancer cells by transcriptionally upregulating PFKFB3. Oncogene. PMID 36064579 DOI: 10.1038/s41388-022-02453-0 |
0.317 |
|
| 2022 |
Li FL, Fu V, Liu G, Tang T, Konradi AW, Peng X, Kemper E, Cravatt BF, Franklin JM, Wu Z, Mayfield J, Dixon JE, Gerwick WH, Guan KL. Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides. Nature Chemical Biology. PMID 35788180 DOI: 10.1038/s41589-022-01061-z |
0.54 |
|
| 2022 |
Meng Z, Li FL, Fang C, Yeoman B, Qiu Y, Wang Y, Cai X, Lin KC, Yang D, Luo M, Fu V, Ma X, Diao Y, Giancotti FG, Ren B, ... Guan KL, et al. The Hippo pathway mediates Semaphorin signaling. Science Advances. 8: eabl9806. PMID 35613278 DOI: 10.1126/sciadv.abl9806 |
0.392 |
|
| 2022 |
Russell RC, Guan KL. The multifaceted role of autophagy in cancer. The Embo Journal. e110031. PMID 35535466 DOI: 10.15252/embj.2021110031 |
0.691 |
|
| 2022 |
Luo M, Hu Y, Wei X, Guan KL. Protocols for measuring phosphorylation, subcellular localization, and kinase activity of Hippo pathway components YAP and LATS in cultured cells. Star Protocols. 3: 101102. PMID 35535164 DOI: 10.1016/j.xpro.2021.101102 |
0.333 |
|
| 2022 |
Zhong Y, Zhou X, Guan KL, Zhang J. Rheb regulates nuclear mTORC1 activity independent of farnesylation. Cell Chemical Biology. PMID 35294906 DOI: 10.1016/j.chembiol.2022.02.006 |
0.318 |
|
| 2021 |
Zhao B, Kim J, Ye X, Lai ZC, Guan KL. Editor's Note: Both TEAD-Binding and WW Domains Are Required for the Growth Stimulation and Oncogenic Transformation Activity of Yes-Associated Protein. Cancer Research. 81: 5583. PMID 34725135 DOI: 10.1158/0008-5472.CAN-21-2838 |
0.317 |
|
| 2020 |
Wu Z, Guan KL. Hippo Signaling in Embryogenesis and Development. Trends in Biochemical Sciences. PMID 32928629 DOI: 10.1016/J.Tibs.2020.08.008 |
0.416 |
|
| 2020 |
Lin Z, Xie R, Guan K, Zhang M. A WW Tandem-Mediated Dimerization Mode of SAV1 Essential for Hippo Signaling. Cell Reports. 32: 108118. PMID 32905778 DOI: 10.1016/J.Celrep.2020.108118 |
0.418 |
|
| 2020 |
Xia YK, Zeng YR, Zhang ML, Liu P, Liu F, Zhang H, He CX, Sun YP, Zhang JY, Zhang C, Song L, Ding C, Tang YJ, Yang Z, Yang C, ... Guan KL, et al. Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network. Protein & Cell. PMID 32683582 DOI: 10.1007/S13238-020-00754-2 |
0.361 |
|
| 2020 |
Cheng ZL, Zhang ML, Lin HP, Gao C, Song JB, Zheng Z, Li L, Zhang Y, Shen X, Zhang H, Huang Z, Zhan W, Zhang C, Hu X, Sun YP, ... Guan KL, et al. The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming. Cell Reports. 32: 107877. PMID 32668244 DOI: 10.1016/J.Celrep.2020.107877 |
0.575 |
|
| 2020 |
Dey A, Varelas X, Guan KL. Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine. Nature Reviews. Drug Discovery. PMID 32555376 DOI: 10.1038/S41573-020-0070-Z |
0.419 |
|
| 2020 |
Zhu H, Blum RH, Bernareggi D, Ask EH, Wu Z, Hoel HJ, Meng Z, Wu C, Guan KL, Malmberg KJ, Kaufman DS. Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity. Cell Stem Cell. PMID 32531207 DOI: 10.1016/J.Stem.2020.05.008 |
0.379 |
|
| 2020 |
Fu V, Guan KL. Tales from the Cryptkeeper: New Roles for Lats1/2 in Wnt-driven Homeostasis. Cell Stem Cell. 26: 612-614. PMID 32386550 DOI: 10.1016/J.Stem.2020.04.011 |
0.339 |
|
| 2020 |
Franklin JM, Guan KL. YAP/TAZ phase separation for transcription. Nature Cell Biology. PMID 32203419 DOI: 10.1038/S41556-020-0498-8 |
0.318 |
|
| 2020 |
Hong AW, Meng Z, Plouffe SW, Lin Z, Zhang M, Guan KL. Critical roles of phosphoinositides and NF2 in Hippo pathway regulation. Genes & Development. PMID 32115406 DOI: 10.1101/Gad.333435.119 |
0.451 |
|
| 2020 |
Chen R, Xie R, Meng Z, Ma S, Guan KL. Publisher Correction: STRIPAK integrates upstream signals to initiate the Hippo kinase cascade. Nature Cell Biology. PMID 31896773 DOI: 10.1038/S41556-019-0460-9 |
0.367 |
|
| 2020 |
Guan K. Abstract IA04: Regulation of the Hippo pathway in cancer Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Hippo19-Ia04 |
0.469 |
|
| 2020 |
Wang X, Radhakrishnan A, Covey D, Horton J, Schwabe R, Tontonoz P, Guan K, Tabas I. Abstract B04: Hepatic cholesterol upregulates TAZ in nonalcoholic steatohepatitis Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Hippo19-B04 |
0.361 |
|
| 2020 |
Zhong Y, Zhou X, Guan K, Zhang J. Constitutively Active Rheb Regulates Nuclear mTORC1 Activity and Function The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.07130 |
0.382 |
|
| 2019 |
Koo JH, Plouffe SW, Meng Z, Lee DH, Yang D, Lim DS, Wang CY, Guan KL. Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth. Genes & Development. PMID 31831627 DOI: 10.1101/Gad.331546.119 |
0.43 |
|
| 2019 |
Chen R, Xie R, Meng Z, Ma S, Guan KL. STRIPAK integrates upstream signals to initiate the Hippo kinase cascade. Nature Cell Biology. PMID 31792377 DOI: 10.1038/S41556-019-0426-Y |
0.509 |
|
| 2019 |
Major LG, Holle AW, Young JL, Hepburn MS, Jeong K, Chin IL, Sanderson RW, Jeong JH, Aman ZM, Kennedy BF, Hwang Y, Han DW, Park HW, Guan KL, Spatz JP, et al. Volume adaptation controls stem cell mechanotransduction. Acs Applied Materials & Interfaces. PMID 31714734 DOI: 10.1021/Acsami.9B19770 |
0.33 |
|
| 2019 |
Shi H, Chapman NM, Wen J, Guy C, Long L, Dhungana Y, Rankin S, Pelletier S, Vogel P, Wang H, Peng J, Guan KL, Chi H. Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity. PMID 31668641 DOI: 10.1016/J.Immuni.2019.10.001 |
0.466 |
|
| 2019 |
Wang TX, Liang JY, Zhang C, Xiong Y, Guan KL, Yuan HX. The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis. Cell Death & Disease. 10: 755. PMID 31591388 DOI: 10.1038/S41419-019-1984-4 |
0.349 |
|
| 2019 |
Lin Z, Yang Z, Xie R, Ji Z, Guan K, Zhang M. Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity. Elife. 8. PMID 31486770 DOI: 10.7554/Elife.49439 |
0.36 |
|
| 2019 |
Li MT, Liang JY, Sun YP, Jin J, Xiong Y, Guan KL, Yuan HX. ELP3 acetyltransferase is phosphorylated and regulated by the oncogenic anaplastic lymphoma kinase (ALK). The Biochemical Journal. PMID 31341009 DOI: 10.1042/Bcj20190106 |
0.475 |
|
| 2019 |
Jewell JL, Fu V, Hong AW, Yu FX, Meng D, Melick CH, Wang H, Lam WM, Yuan HX, Taylor SS, Guan KL. GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor. Elife. 8. PMID 31112131 DOI: 10.7554/Elife.43038 |
0.712 |
|
| 2019 |
Li L, Guan KL. Correction: Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) is a negative regulator of the mammalian target of rapamycin complex 1 (mTORC1). The Journal of Biological Chemistry. 294: 5810. PMID 30979852 DOI: 10.1074/jbc.AAC119.008438 |
0.318 |
|
| 2019 |
Zhang H, Liu CY, Zha ZY, Zhao B, Yao J, Zhao S, Xiong Y, Lei QY, Guan KL. Correction: TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. The Journal of Biological Chemistry. 294: 5808. PMID 30979850 DOI: 10.1074/jbc.AAC119.008436 |
0.328 |
|
| 2019 |
Verma S, Yeddula N, Soda Y, Zhu Q, Pao G, Moresco J, Diedrich JK, Hong A, Plouffe S, Moroishi T, Guan KL, Verma IM. BRCA1/BARD1-dependent ubiquitination of NF2 regulates Hippo-YAP1 signaling. Proceedings of the National Academy of Sciences of the United States of America. PMID 30918126 DOI: 10.1073/Pnas.1822155116 |
0.491 |
|
| 2019 |
Zhang M, Wu J, Sun R, Tao X, Wang X, Kang Q, Wang H, Zhang L, Liu P, Zhang J, Xia Y, Zhao Y, Yang Y, Xiong Y, Guan KL, et al. SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress. Plos One. 14: e0211796. PMID 30759120 DOI: 10.1371/Journal.Pone.0211796 |
0.381 |
|
| 2019 |
Kim J, Guan KL. mTOR as a central hub of nutrient signalling and cell growth. Nature Cell Biology. 21: 63-71. PMID 30602761 DOI: 10.1038/S41556-018-0205-1 |
0.466 |
|
| 2019 |
Chen R, Plouffe SW, Guan KL. Determining the Phosphorylation Status of Hippo Components YAP and TAZ Using Phos-tag. Methods in Molecular Biology (Clifton, N.J.). 1893: 281-287. PMID 30565141 DOI: 10.1007/978-1-4939-8910-2_21 |
0.425 |
|
| 2019 |
Jewell JL, Fu V, Hong AW, Yu F, Meng D, Melick CH, Wang H, Lam WM, Yuan H, Taylor SS, Guan K. Author response: GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor Elife. DOI: 10.7554/Elife.43038.019 |
0.666 |
|
| 2019 |
Zhu H, Blum R, Wu Z, Meng Z, Guan K, Kaufman DS. Deletion of CISH in Human Pluripotent Stem Cell-Derived Natural Killer Cells Enhances Anti-Tumor Activity Via Metabolic Reprogramming Blood. 134: 619-619. DOI: 10.1182/Blood-2019-124446 |
0.301 |
|
| 2019 |
Guan K. Abstract SY40-01: The hippo pathway in growth, regeneration, and cancer Cancer Research. 79. DOI: 10.1158/1538-7445.Am2019-Sy40-01 |
0.46 |
|
| 2018 |
Ma S, Meng Z, Chen R, Guan KL. The Hippo Pathway: Biology and Pathophysiology. Annual Review of Biochemistry. PMID 30566373 DOI: 10.1146/Annurev-Biochem-013118-111829 |
0.483 |
|
| 2018 |
Pan WW, Moroishi T, Koo JH, Guan KL. Cell type-dependent function of LATS1/2 in cancer cell growth. Oncogene. PMID 30531839 DOI: 10.1038/S41388-018-0610-8 |
0.452 |
|
| 2018 |
Zhang Z, Du J, Wang S, Shao L, Jin K, Li F, Wei B, Ding W, Fu P, van Dam H, Wang A, Jin J, Ding C, Yang B, Zheng M, ... Guan KL, et al. OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ. Molecular Cell. PMID 30472188 DOI: 10.1016/J.Molcel.2018.10.030 |
0.432 |
|
| 2018 |
Badur MG, Muthusamy T, Parker SJ, Ma S, McBrayer SK, Cordes T, Magana JH, Guan KL, Metallo CM. Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells. Cell Reports. 25: 1018-1026.e4. PMID 30355481 DOI: 10.1016/J.Celrep.2018.09.074 |
0.313 |
|
| 2018 |
Han H, Qi R, Zhou JJ, Ta AP, Yang B, Nakaoka HJ, Seo G, Guan KL, Luo R, Wang W. Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction. Molecular Cell. PMID 30293781 DOI: 10.1016/J.Molcel.2018.08.038 |
0.438 |
|
| 2018 |
Meng Z, Qiu Y, Lin KC, Kumar A, Placone JK, Fang C, Wang KC, Lu S, Pan M, Hong AW, Moroishi T, Luo M, Plouffe SW, Diao Y, Ye Z, ... Guan KL, et al. RAP2 mediates mechanoresponses of the Hippo pathway. Nature. PMID 30135582 DOI: 10.1038/S41586-018-0444-0 |
0.367 |
|
| 2018 |
Koo JH, Guan KL. Interplay between YAP/TAZ and Metabolism. Cell Metabolism. 28: 196-206. PMID 30089241 DOI: 10.1016/J.Cmet.2018.07.010 |
0.406 |
|
| 2018 |
Martin D, Degese MS, Vitale-Cross L, Iglesias-Bartolome R, Valera JLC, Wang Z, Feng X, Yeerna H, Vadmal V, Moroishi T, Thorne RF, Zaida M, Siegele B, Cheong SC, Molinolo AA, ... ... Guan KL, et al. Assembly and activation of the Hippo signalome by FAT1 tumor suppressor. Nature Communications. 9: 2372. PMID 29985391 DOI: 10.1038/s41467-018-04590-1 |
0.322 |
|
| 2018 |
Ma S, Guan KL. Polycystic kidney disease: a Hippo connection. Genes & Development. 32: 737-739. PMID 29921661 DOI: 10.1101/Gad.316570.118 |
0.318 |
|
| 2018 |
Yu OM, Benitez JA, Plouffe SW, Ryback D, Klein A, Smith J, Greenbaum J, Delatte B, Rao A, Guan KL, Furnari FB, Chaim OM, Miyamoto S, Brown JH. YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity. Oncogene. PMID 29887596 DOI: 10.1038/S41388-018-0301-5 |
0.442 |
|
| 2018 |
Plouffe SW, Lin KC, Moore JL, Tan FE, Ma S, Ye Z, Qiu Y, Ren B, Guan KL. The Hippo pathway effector proteins YAP and TAZ have both distinct and overlapping functions in the cell. The Journal of Biological Chemistry. PMID 29802201 DOI: 10.1074/Jbc.Ra118.002715 |
0.486 |
|
| 2018 |
Li FL, Liu JP, Bao RX, Yan G, Feng X, Xu YP, Sun YP, Yan W, Ling ZQ, Xiong Y, Guan KL, Yuan HX. Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis. Nature Communications. 9: 508. PMID 29410405 DOI: 10.1038/S41467-018-02950-5 |
0.432 |
|
| 2018 |
Zhou B, Flodby P, Luo J, Castillo DR, Liu Y, Yu FX, McConnell A, Varghese B, Li G, Chimge NO, Sunohara M, Koss MN, Elatre W, Conti P, Liebler JM, ... ... Guan K, et al. Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis. The Journal of Clinical Investigation. PMID 29400695 DOI: 10.1172/Jci90429 |
0.385 |
|
| 2018 |
Liu MX, Jin L, Sun SJ, Liu P, Feng X, Cheng ZL, Liu WR, Guan KL, Shi YH, Yuan HX, Xiong Y. Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma. Oncogene. PMID 29335519 DOI: 10.1038/S41388-017-0070-6 |
0.322 |
|
| 2018 |
Fu V, Plouffe SW, Guan KL. The Hippo pathway in organ development, homeostasis, and regeneration. Current Opinion in Cell Biology. 49: 99-107. PMID 29316535 DOI: 10.1016/J.Ceb.2017.12.012 |
0.41 |
|
| 2018 |
Moreno E, Guan K, Halder G. Decision letter: Nerfin-1 represses transcriptional output of Hippo signaling in cell competition Elife. DOI: 10.7554/Elife.38843.015 |
0.332 |
|
| 2018 |
Stoner SA, Yan M, Liu K, Shima T, Wang H, Arimoto K, Bejar R, Jamieson C, Guan K, Zhang D. Hippo Kinase Inactivation Contributes to Del(20q) Malignancies and Cooperates with JAK2-V617F to Promote Myelofibrosis in Mice Blood. 132: 99-99. DOI: 10.1182/Blood-2018-99-115591 |
0.319 |
|
| 2018 |
Zhu H, Blum R, Wu Z, Bahena A, Hoel HJ, Ask EH, Guan K, Malmberg K, Kaufman DS. Notch Activation Rescues Exhaustion in CISH-Deleted Human iPSC-Derived Natural Killer Cells to Promote In Vivo Persistence and Enhance Anti-Tumor Activity Blood. 132: 1279-1279. DOI: 10.1182/Blood-2018-99-112791 |
0.314 |
|
| 2017 |
Lin KC, Park HW, Guan KL. Regulation of the Hippo Pathway Transcription Factor TEAD. Trends in Biochemical Sciences. PMID 28964625 DOI: 10.1016/j.tibs.2017.09.003 |
0.361 |
|
| 2017 |
Mo Y, Lin R, Liu P, Tan M, Xiong Y, Guan KL, Yuan HX. SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes. The Febs Journal. PMID 28886238 DOI: 10.1111/Febs.14259 |
0.409 |
|
| 2017 |
Lin KC, Moroishi T, Meng Z, Jeong HS, Plouffe SW, Sekido Y, Han J, Park HW, Guan KL. Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation. Nature Cell Biology. 19: 996-1002. PMID 28752853 DOI: 10.1038/ncb3581 |
0.412 |
|
| 2017 |
Gu Y, Albuquerque CP, Braas D, Zhang W, Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, Gahman TC, Shiau AK, Cloughesy TF, Christofk HR, Zhou H, Guan KL, et al. mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT. Molecular Cell. PMID 28648777 DOI: 10.1016/J.Molcel.2017.05.030 |
0.426 |
|
| 2017 |
Strnadel J, Choi S, Fujimura K, Wang H, Zhang W, Wyse M, Wright T, Gross E, Peinado C, Park HW, Bui J, Kelber J, Bouvet M, Guan KL, Klemke RL. eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth. Cancer Research. PMID 28381547 DOI: 10.1158/0008-5472.Can-16-2594 |
0.337 |
|
| 2017 |
Zhang Q, Meng F, Chen S, Plouffe SW, Wu S, Liu S, Li X, Zhou R, Wang J, Zhao B, Liu J, Qin J, Zou J, Feng XH, Guan KL, et al. Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade. Nature Cell Biology. PMID 28346439 DOI: 10.1038/Ncb3496 |
0.531 |
|
| 2017 |
Wang Z, Liu P, Zhou X, Wang T, Feng X, Sun YP, Xiong Y, Yuan HX, Guan KL. Endothelin promotes colorectal tumorigenesis by activating YAP/TAZ. Cancer Research. PMID 28249901 DOI: 10.1158/0008-5472.Can-16-3229 |
0.359 |
|
| 2017 |
Ma X, Zhang S, He L, Rong Y, Wilz Brier L, Sun Q, Liu R, Fan W, Chen S, Yue Z, Kim J, Guan KL, Li D, Zhong Q. MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy. Autophagy. 0. PMID 28059666 DOI: 10.1080/15548627.2016.1269988 |
0.357 |
|
| 2016 |
Hong AW, Meng Z, Yuan HX, Plouffe SW, Moon S, Kim W, Jho EH, Guan KL. Osmotic stress-induced phosphorylation by NLK at Ser128 activates YAP. Embo Reports. PMID 27979971 DOI: 10.15252/Embr.201642681 |
0.48 |
|
| 2016 |
Plouffe SW, Meng Z, Lin KC, Lin B, Hong AW, Chun JV, Guan KL. Characterization of Hippo Pathway Components by Gene Inactivation. Molecular Cell. 64: 993-1008. PMID 27912098 DOI: 10.1016/J.Molcel.2016.10.034 |
0.441 |
|
| 2016 |
Moroishi T, Hayashi T, Pan WW, Fujita Y, Holt MV, Qin J, Carson DA, Guan KL. The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity. Cell. 167: 1525-1539.e17. PMID 27912060 DOI: 10.1016/J.Cell.2016.11.005 |
0.304 |
|
| 2016 |
Wang KC, Yeh YT, Nguyen P, Limqueco E, Lopez J, Thorossian S, Guan KL, Li YJ, Chien S. Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 27671657 DOI: 10.1073/Pnas.1613121113 |
0.36 |
|
| 2016 |
Zha Z, Han XR, Smith MD, Lei QY, Guan KL, Xiong Y. Hypertension-associated C825T polymorphism impairs the function of Gβ3 to target GRK2 ubiquitination. Cell Discovery. 2: 16005. PMID 27462452 DOI: 10.1038/Celldisc.2016.5 |
0.312 |
|
| 2016 |
Hong AW, Meng Z, Guan KL. The Hippo pathway in intestinal regeneration and disease. Nature Reviews. Gastroenterology & Hepatology. PMID 27147489 DOI: 10.1038/Nrgastro.2016.59 |
0.46 |
|
| 2016 |
Meng F, Zhou R, Wu S, Zhang Q, Jin Q, Zhou Y, Plouffe SW, Liu S, Song H, Xia Z, Zhao B, Ye S, Feng XH, Guan KL, Zou J, et al. Mst1 shuts off cytosolic antiviral defense through IRF3 phosphorylation. Genes & Development. PMID 27125670 DOI: 10.1101/Gad.277533.116 |
0.546 |
|
| 2016 |
Diao Y, Li B, Meng Z, Jung I, Lee A, Dixon J, Maliskova L, Guan KL, Shen Y, Ren B. A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9 mediated genetic screening. Genome Research. PMID 26813977 DOI: 10.1101/Gr.197152.115 |
0.329 |
|
| 2016 |
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... Guan KL, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356 |
0.505 |
|
| 2016 |
Yuan HX, Guan KL. Structural insights of mTOR complex 1. Cell Research. PMID 26794870 DOI: 10.1038/Cr.2016.10 |
0.423 |
|
| 2016 |
Meng Z, Moroishi T, Guan KL. Mechanisms of Hippo pathway regulation. Genes & Development. 30: 1-17. PMID 26728553 DOI: 10.1101/Gad.274027.115 |
0.497 |
|
| 2016 |
Han XR, Zha Z, Yuan HX, Feng X, Xia YK, Lei QY, Guan KL, Xiong Y. KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation. Oncogene. PMID 26725323 DOI: 10.1038/Onc.2015.482 |
0.381 |
|
| 2016 |
Stoner SA, Andrews ET, Dekelver R, Weng S, Lo M, Guan K, Zhang D. RUNX1-ETO-Dependent Transcriptional Repression of RASSF2 Contributes to t(8;21) Leukemia through Evasion of MST1-Driven Apoptosis Signaling Blood. 128: 1547-1547. DOI: 10.1182/Blood.V128.22.1547.1547 |
0.344 |
|
| 2015 |
Lyubasyuk V, Ouyang H, Yu FX, Guan KL, Zhang K. YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations. Molecular & Cellular Oncology. 2: e970957. PMID 27308390 DOI: 10.4161/23723548.2014.970957 |
0.309 |
|
| 2015 |
Hansen CG, Ng YL, Lam WM, Plouffe SW, Guan KL. The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1. Cell Research. PMID 26611634 DOI: 10.1038/Cr.2015.140 |
0.481 |
|
| 2015 |
Yuan HX, Wang Z, Yu FX, Li F, Russell RC, Jewell JL, Guan KL. NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition. Genes & Development. 29: 2362-76. PMID 26588989 DOI: 10.1101/Gad.265116.115 |
0.8 |
|
| 2015 |
Yu FX, Zhao B, Guan KL. Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. Cell. 163: 811-28. PMID 26544935 DOI: 10.1016/J.Cell.2015.10.044 |
0.449 |
|
| 2015 |
Yuan HX, Guan KL. The SIN1-PH Domain Connects mTORC2 to PI3K. Cancer Discovery. 5: 1127-9. PMID 26526694 DOI: 10.1158/2159-8290.Cd-15-1125 |
0.421 |
|
| 2015 |
Ma T, Li J, Xu Y, Yu C, Xu T, Wang H, Liu K, Cao N, Nie BM, Zhu SY, Xu S, Li K, Wei WG, Wu Y, Guan KL, et al. Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming. Nature Cell Biology. PMID 26502054 DOI: 10.1038/Ncb3256 |
0.33 |
|
| 2015 |
Meng Z, Moroishi T, Mottier-Pavie V, Plouffe SW, Hansen CG, Hong AW, Park HW, Mo JS, Lu W, Lu S, Flores F, Yu FX, Halder G, Guan KL. MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nature Communications. 6: 8357. PMID 26437443 DOI: 10.1038/ncomms9357 |
0.396 |
|
| 2015 |
Sig Kim J, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan KL, Karin M, Hee Lee J. Corrigendum: Sestrin2 inhibits mTORC1 through modulation of GATOR complexes. Scientific Reports. 5: 14029. PMID 26390293 DOI: 10.1038/Srep14029 |
0.35 |
|
| 2015 |
Nemazanyy I, Montagnac G, Russell RC, Morzyglod L, Burnol AF, Guan KL, Pende M, Panasyuk G. Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. Nature Communications. 6: 8283. PMID 26387534 DOI: 10.1038/Ncomms9283 |
0.693 |
|
| 2015 |
Wang S, Jiang B, Zhang T, Liu L, Wang Y, Wang Y, Chen X, Lin H, Zhou L, Xia Y, Chen L, Yang C, Xiong Y, Ye D, Guan KL. Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1. Plos Biology. 13: e1002243. PMID 26356530 DOI: 10.1371/Journal.Pbio.1002243 |
0.331 |
|
| 2015 |
Ha J, Guan KL, Kim J. AMPK and autophagy in glucose/glycogen metabolism. Molecular Aspects of Medicine. PMID 26297963 DOI: 10.1016/J.Mam.2015.08.002 |
0.382 |
|
| 2015 |
Park HW, Kim YC, Yu B, Moroishi T, Mo JS, Plouffe SW, Meng Z, Lin KC, Yu FX, Alexander CM, Wang CY, Guan KL. Alternative Wnt Signaling Activates YAP/TAZ. Cell. 162: 780-94. PMID 26276632 DOI: 10.1016/J.Cell.2015.07.013 |
0.306 |
|
| 2015 |
Gong R, Hong AW, Plouffe SW, Zhao B, Liu G, Yu FX, Xu Y, Guan KL. Opposing roles of conventional and novel PKC isoforms in Hippo-YAP pathway regulation. Cell Research. PMID 26206313 DOI: 10.1038/Cr.2015.88 |
0.577 |
|
| 2015 |
Lv XB, Liu CY, Wang Z, Sun YP, Xiong Y, Lei QY, Guan KL. PARD3 induces TAZ activation and cell growth by promoting LATS1 and PP1 interaction. Embo Reports. PMID 26116754 DOI: 10.15252/Embr.201439951 |
0.455 |
|
| 2015 |
Moroishi T, Park HW, Qin B, Chen Q, Meng Z, Plouffe SW, Taniguchi K, Yu FX, Karin M, Pan D, Guan KL. A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis. Genes & Development. 29: 1271-84. PMID 26109050 DOI: 10.1101/gad.262816.115 |
0.416 |
|
| 2015 |
Li W, Guan KL. The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak. The Journal of Biological Chemistry. 290: 14797. PMID 26048998 DOI: 10.1074/Jbc.A115.401878 |
0.402 |
|
| 2015 |
Hansen CG, Moroishi T, Guan KL. YAP and TAZ: a nexus for Hippo signaling and beyond. Trends in Cell Biology. PMID 26045258 DOI: 10.1016/J.Tcb.2015.05.002 |
0.455 |
|
| 2015 |
Qi Q, Li DY, Luo HR, Guan KL, Ye K. Netrin-1 exerts oncogenic activities through enhancing Yes-associated protein stability. Proceedings of the National Academy of Sciences of the United States of America. 112: 7255-60. PMID 26039999 DOI: 10.1073/pnas.1505917112 |
0.396 |
|
| 2015 |
Zhou Q, Li L, Zhao B, Guan KL. The hippo pathway in heart development, regeneration, and diseases. Circulation Research. 116: 1431-47. PMID 25858067 DOI: 10.1161/Circresaha.116.303311 |
0.498 |
|
| 2015 |
Kim JS, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan KL, Karin M, Lee JH. Sestrin2 inhibits mTORC1 through modulation of GATOR complexes. Scientific Reports. 5: 9502. PMID 25819761 DOI: 10.1038/Srep09502 |
0.35 |
|
| 2015 |
Mo JS, Meng Z, Kim YC, Park HW, Hansen CG, Kim S, Lim DS, Guan KL. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nature Cell Biology. 17: 500-10. PMID 25751140 DOI: 10.1038/ncb3111 |
0.423 |
|
| 2015 |
Plouffe SW, Hong AW, Guan KL. Disease implications of the Hippo/YAP pathway. Trends in Molecular Medicine. 21: 212-22. PMID 25702974 DOI: 10.1016/J.Molmed.2015.01.003 |
0.455 |
|
| 2015 |
Jewell JL, Flores F, Guan KL. Micro(RNA) managing by mTORC1. Molecular Cell. 57: 575-6. PMID 25699705 DOI: 10.1016/J.Molcel.2015.02.006 |
0.566 |
|
| 2015 |
Kim YC, Guan KL. mTOR: a pharmacologic target for autophagy regulation. The Journal of Clinical Investigation. 125: 25-32. PMID 25654547 DOI: 10.1172/Jci73939 |
0.486 |
|
| 2015 |
Moroishi T, Hansen CG, Guan KL. The emerging roles of YAP and TAZ in cancer. Nature Reviews. Cancer. 15: 73-9. PMID 25592648 DOI: 10.1038/Nrc3876 |
0.402 |
|
| 2015 |
Jewell JL, Kim YC, Russell RC, Yu FX, Park HW, Plouffe SW, Tagliabracci VS, Guan KL. Metabolism. Differential regulation of mTORC1 by leucine and glutamine. Science (New York, N.Y.). 347: 194-8. PMID 25567907 DOI: 10.1126/Science.1259472 |
0.811 |
|
| 2015 |
Yu FX, Meng Z, Plouffe SW, Guan KL. Hippo pathway regulation of gastrointestinal tissues. Annual Review of Physiology. 77: 201-27. PMID 25293527 DOI: 10.1146/Annurev-Physiol-021014-071733 |
0.366 |
|
| 2015 |
Liu G, Yu FX, Kim YC, Meng Z, Naipauer J, Looney DJ, Liu X, Gutkind JS, Mesri EA, Guan KL. Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway. Oncogene. 34: 3536-46. PMID 25195862 DOI: 10.1038/Onc.2014.281 |
0.451 |
|
| 2014 |
Parmigiani A, Nourbakhsh A, Ding B, Wang W, Kim YC, Akopiants K, Guan KL, Karin M, Budanov AV. Sestrins inhibit mTORC1 kinase activation through the GATOR complex. Cell Reports. 9: 1281-91. PMID 25457612 DOI: 10.1016/J.Celrep.2014.10.019 |
0.497 |
|
| 2014 |
Zhao B, Guan KL. Hippo pathway key to ploidy checkpoint. Cell. 158: 695-6. PMID 25126776 DOI: 10.1016/J.Cell.2014.07.041 |
0.498 |
|
| 2014 |
Gao Y, Zhang W, Han X, Li F, Wang X, Wang R, Fang Z, Tong X, Yao S, Li F, Feng Y, Sun Y, Hou Y, Yang Z, Guan K, et al. YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression. Nature Communications. 5: 4629. PMID 25115923 DOI: 10.1038/Ncomms5629 |
0.355 |
|
| 2014 |
Kim YC, Park HW, Sciarretta S, Mo JS, Jewell JL, Russell RC, Wu X, Sadoshima J, Guan KL. Rag GTPases are cardioprotective by regulating lysosomal function. Nature Communications. 5: 4241. PMID 24980141 DOI: 10.1038/Ncomms5241 |
0.788 |
|
| 2014 |
Luk JM, Guan KL. An alternative DNA damage pathway to apoptosis in hematological cancers. Nature Medicine. 20: 587-8. PMID 24901566 DOI: 10.1038/Nm.3593 |
0.37 |
|
| 2014 |
Yu FX, Luo J, Mo JS, Liu G, Kim YC, Meng Z, Zhao L, Peyman G, Ouyang H, Jiang W, Zhao J, Chen X, Zhang L, Wang CY, Bastian BC, ... Guan KL, et al. Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Cancer Cell. 25: 822-30. PMID 24882516 DOI: 10.1016/J.Ccr.2014.04.017 |
0.4 |
|
| 2014 |
Mo JS, Park HW, Guan KL. The Hippo signaling pathway in stem cell biology and cancer. Embo Reports. 15: 642-56. PMID 24825474 DOI: 10.15252/embr.201438638 |
0.336 |
|
| 2014 |
Xu Y, Li F, Lv L, Li T, Zhou X, Deng CX, Guan KL, Lei QY, Xiong Y. Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase. Cancer Research. 74: 3630-42. PMID 24786789 DOI: 10.1158/0008-5472.Can-13-3615 |
0.312 |
|
| 2014 |
Wang P, Zhou Z, Hu A, Ponte de Albuquerque C, Zhou Y, Hong L, Sierecki E, Ajiro M, Kruhlak M, Harris C, Guan KL, Zheng ZM, Newton AC, Sun P, Zhou H, et al. Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt. Molecular Cell. 54: 378-91. PMID 24703948 DOI: 10.1016/J.Molcel.2014.03.007 |
0.494 |
|
| 2014 |
Yu FX, Guan KL. Transcription and processing: multilayer controls of RNA biogenesis by the Hippo pathway. The Embo Journal. 33: 942-4. PMID 24639555 DOI: 10.1002/Embj.201488329 |
0.452 |
|
| 2014 |
Russell RC, Yuan HX, Guan KL. Autophagy regulation by nutrient signaling. Cell Research. 24: 42-57. PMID 24343578 DOI: 10.1038/Cr.2013.166 |
0.778 |
|
| 2013 |
Li J, Chen X, Ding X, Cheng Y, Zhao B, Lai ZC, Al Hezaimi K, Hakem R, Guan KL, Wang CY. LATS2 suppresses oncogenic Wnt signaling by disrupting β-catenin/BCL9 interaction. Cell Reports. 5: 1650-63. PMID 24360964 DOI: 10.1016/J.Celrep.2013.11.037 |
0.476 |
|
| 2013 |
Lv L, Xu YP, Zhao D, Li FL, Wang W, Sasaki N, Jiang Y, Zhou X, Li TT, Guan KL, Lei QY, Xiong Y. Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization. Molecular Cell. 52: 340-52. PMID 24120661 DOI: 10.1016/J.Molcel.2013.09.004 |
0.32 |
|
| 2013 |
Dai X, She P, Chi F, Feng Y, Liu H, Jin D, Zhao Y, Guo X, Jiang D, Guan KL, Zhong TP, Zhao B. Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration, and angiogenesis. The Journal of Biological Chemistry. 288: 34041-51. PMID 24106267 DOI: 10.1074/Jbc.M113.518019 |
0.451 |
|
| 2013 |
Park HW, Guan KL. Regulation of the Hippo pathway and implications for anticancer drug development. Trends in Pharmacological Sciences. 34: 581-9. PMID 24051213 DOI: 10.1016/j.tips.2013.08.006 |
0.355 |
|
| 2013 |
Yuan HX, Russell RC, Guan KL. Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy. Autophagy. 9: 1983-95. PMID 24013218 DOI: 10.4161/Auto.26058 |
0.767 |
|
| 2013 |
Yu FX, Zhang Y, Park HW, Jewell JL, Chen Q, Deng Y, Pan D, Taylor SS, Lai ZC, Guan KL. Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation. Genes & Development. 27: 1223-32. PMID 23752589 DOI: 10.1101/Gad.219402.113 |
0.715 |
|
| 2013 |
Russell RC, Tian Y, Yuan H, Park HW, Chang YY, Kim J, Kim H, Neufeld TP, Dillin A, Guan KL. ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nature Cell Biology. 15: 741-50. PMID 23685627 DOI: 10.1038/Ncb2757 |
0.746 |
|
| 2013 |
Kim J, Guan KL. AMPK connects energy stress to PIK3C3/VPS34 regulation. Autophagy. 9: 1110-1. PMID 23669030 DOI: 10.4161/Auto.24877 |
0.412 |
|
| 2013 |
Nemazanyy I, Blaauw B, Paolini C, Caillaud C, Protasi F, Mueller A, Proikas-Cezanne T, Russell RC, Guan KL, Nishino I, Sandri M, Pende M, Panasyuk G. Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease. Embo Molecular Medicine. 5: 870-90. PMID 23630012 DOI: 10.1002/Emmm.201202057 |
0.739 |
|
| 2013 |
Jewell JL, Guan KL. Nutrient signaling to mTOR and cell growth. Trends in Biochemical Sciences. 38: 233-42. PMID 23465396 DOI: 10.1016/J.Tibs.2013.01.004 |
0.696 |
|
| 2013 |
Yu FX, Guan KL. The Hippo pathway: regulators and regulations. Genes & Development. 27: 355-71. PMID 23431053 DOI: 10.1101/Gad.210773.112 |
0.46 |
|
| 2013 |
Yuan HX, Xiong Y, Guan KL. Nutrient sensing, metabolism, and cell growth control. Molecular Cell. 49: 379-87. PMID 23395268 DOI: 10.1016/J.Molcel.2013.01.019 |
0.31 |
|
| 2013 |
Jewell JL, Russell RC, Guan KL. Amino acid signalling upstream of mTOR. Nature Reviews. Molecular Cell Biology. 14: 133-9. PMID 23361334 DOI: 10.1038/Nrm3522 |
0.784 |
|
| 2013 |
Kim J, Kim YC, Fang C, Russell RC, Kim JH, Fan W, Liu R, Zhong Q, Guan KL. Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell. 152: 290-303. PMID 23332761 DOI: 10.1016/j.cell.2012.12.016 |
0.732 |
|
| 2013 |
Li L, Guan KL. Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) is a negative regulator of the mammalian target of rapamycin complex 1 (mTORC1). The Journal of Biological Chemistry. 288: 703-8. PMID 23184942 DOI: 10.1074/Jbc.C112.396903 |
0.555 |
|
| 2013 |
Kim J, Russell R, Yuan H, Guan K. Abstract SY08-01: AMPK and mTOR in nutrient signaling, metabolism, and autophagy regulation. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Sy08-01 |
0.491 |
|
| 2013 |
Wang Y, Zhou L, Zhao Y, Wang S, Yang Y, Ye D, Xiong Y, Guan K. Abstract 5177: SIRT2 deacetylates and activates glucose-6-phosphate dehydrogenase (G6PD) to protect cells against oxidative stress. Cancer Research. 73: 5177-5177. DOI: 10.1158/1538-7445.Am2013-5177 |
0.388 |
|
| 2012 |
Tumaneng K, Schlegelmilch K, Russell RC, Yimlamai D, Basnet H, Mahadevan N, Fitamant J, Bardeesy N, Camargo FD, Guan KL. YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29. Nature Cell Biology. 14: 1322-9. PMID 23143395 DOI: 10.1038/Ncb2615 |
0.758 |
|
| 2012 |
Yu FX, Mo JS, Guan KL. Upstream regulators of the Hippo pathway. Cell Cycle (Georgetown, Tex.). 11: 4097-8. PMID 23075495 DOI: 10.4161/Cc.22322 |
0.522 |
|
| 2012 |
Mo JS, Yu FX, Gong R, Brown JH, Guan KL. Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs). Genes & Development. 26: 2138-43. PMID 22972936 DOI: 10.1101/Gad.197582.112 |
0.506 |
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| 2012 |
Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... Guan KL, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496 |
0.55 |
|
| 2012 |
Magee JA, Ikenoue T, Nakada D, Lee JY, Guan KL, Morrison SJ. Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression. Cell Stem Cell. 11: 415-28. PMID 22958933 DOI: 10.1016/J.Stem.2012.05.026 |
0.333 |
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| 2012 |
Yu FX, Zhao B, Panupinthu N, Jewell JL, Lian I, Wang LH, Zhao J, Yuan H, Tumaneng K, Li H, Fu XD, Mills GB, Guan KL. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell. 150: 780-91. PMID 22863277 DOI: 10.1016/J.Cell.2012.06.037 |
0.702 |
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| 2012 |
Tang F, Wu Q, Ikenoue T, Guan KL, Liu Y, Zheng P. A critical role for Rictor in T lymphopoiesis. Journal of Immunology (Baltimore, Md. : 1950). 189: 1850-7. PMID 22815285 DOI: 10.4049/Jimmunol.1201057 |
0.371 |
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| 2012 |
Huang W, Lv X, Liu C, Zha Z, Zhang H, Jiang Y, Xiong Y, Lei QY, Guan KL. The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFβ-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibition. The Journal of Biological Chemistry. 287: 26245-53. PMID 22692215 DOI: 10.1074/Jbc.M112.382036 |
0.411 |
|
| 2012 |
Purohit AA, Li W, Qu C, Dwyer T, Shao Q, Guan KL, Liu G. Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse. The Journal of Biological Chemistry. 287: 27126-38. PMID 22685302 DOI: 10.1074/Jbc.M112.340174 |
0.404 |
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| 2012 |
Hong W, Guan KL. The YAP and TAZ transcription co-activators: key downstream effectors of the mammalian Hippo pathway. Seminars in Cell & Developmental Biology. 23: 785-93. PMID 22659496 DOI: 10.1016/J.Semcdb.2012.05.004 |
0.5 |
|
| 2012 |
Tumaneng K, Russell RC, Guan KL. Organ size control by Hippo and TOR pathways. Current Biology : Cb. 22: R368-79. PMID 22575479 DOI: 10.1016/J.Cub.2012.03.003 |
0.719 |
|
| 2012 |
Valbuena N, Guan KL, Moreno S. The Vam6 and Gtr1-Gtr2 pathway activates TORC1 in response to amino acids in fission yeast. Journal of Cell Science. 125: 1920-8. PMID 22344254 DOI: 10.1242/Jcs.094219 |
0.466 |
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| 2012 |
Zhao B, Li L, Wang L, Wang CY, Yu J, Guan KL. Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis. Genes & Development. 26: 54-68. PMID 22215811 DOI: 10.1101/Gad.173435.111 |
0.486 |
|
| 2012 |
Inoki K, Kim J, Guan KL. AMPK and mTOR in cellular energy homeostasis and drug targets. Annual Review of Pharmacology and Toxicology. 52: 381-400. PMID 22017684 DOI: 10.1146/annurev-pharmtox-010611-134537 |
0.366 |
|
| 2012 |
Zhou X, Li TT, Feng X, Hsiang E, Xiong Y, Guan KL, Lei QY. Targeted polyubiquitylation of RASSF1C by the Mule and SCFβ-TrCP ligases in response to DNA damage. The Biochemical Journal. 441: 227-36. PMID 21910689 DOI: 10.1042/Bj20111500 |
0.342 |
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| 2012 |
Wang P, Dong Q, Zhang C, Kuan P, Liu Y, Jeck WR, Andersen JB, Auman JT, Hoskins JM, Kim JW, Cibulskis K, Getz G, Hunt HV, Thorgeirsson SS, Roberts LR, ... ... Guan K, et al. Abstract 1058: Mutations in isocitrate dehydrogenase 1 and 2 are associated with DNA hypermethylation in intrahepatic cholangiocarcinomas Cancer Research. 72: 1058-1058. DOI: 10.1158/1538-7445.Am2012-1058 |
0.301 |
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| 2011 |
Gong R, Li L, Liu Y, Wang P, Yang H, Wang L, Cheng J, Guan KL, Xu Y. Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation. Genes & Development. 25: 1668-73. PMID 21816923 DOI: 10.1101/Gad.16968011 |
0.397 |
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| 2011 |
Zhao B, Tumaneng K, Guan KL. The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. Nature Cell Biology. 13: 877-83. PMID 21808241 DOI: 10.1038/Ncb2303 |
0.519 |
|
| 2011 |
Russell RC, Fang C, Guan KL. An emerging role for TOR signaling in mammalian tissue and stem cell physiology. Development (Cambridge, England). 138: 3343-56. PMID 21791526 DOI: 10.1242/Dev.058230 |
0.747 |
|
| 2011 |
Yoshida S, Hong S, Suzuki T, Nada S, Mannan AM, Wang J, Okada M, Guan KL, Inoki K. Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway. The Journal of Biological Chemistry. 286: 32651-60. PMID 21784859 DOI: 10.1074/Jbc.M111.238014 |
0.491 |
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| 2011 |
Lv L, Li D, Zhao D, Lin R, Chu Y, Zhang H, Zha Z, Liu Y, Li Z, Xu Y, Wang G, Huang Y, Xiong Y, Guan KL, Lei QY. Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Molecular Cell. 42: 719-30. PMID 21700219 DOI: 10.1016/J.Molcel.2011.04.025 |
0.311 |
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| 2011 |
Kim J, Guan KL. Amino acid signaling in TOR activation. Annual Review of Biochemistry. 80: 1001-32. PMID 21548787 DOI: 10.1146/Annurev-Biochem-062209-094414 |
0.492 |
|
| 2011 |
Xie X, Zhang D, Zhao B, Lu MK, You M, Condorelli G, Wang CY, Guan KL. IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 108: 6474-9. PMID 21464307 DOI: 10.1073/Pnas.1016132108 |
0.475 |
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| 2011 |
Egan D, Kim J, Shaw RJ, Guan KL. The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR. Autophagy. 7: 643-4. PMID 21460621 DOI: 10.4161/Auto.7.6.15123 |
0.489 |
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| 2011 |
Kim J, Guan KL. Regulation of the autophagy initiating kinase ULK1 by nutrients: roles of mTORC1 and AMPK. Cell Cycle (Georgetown, Tex.). 10: 1337-8. PMID 21403467 DOI: 10.4161/Cc.10.9.15291 |
0.464 |
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| 2011 |
Xie X, Guan KL. The ribosome and TORC2: collaborators for cell growth. Cell. 144: 640-2. PMID 21376227 DOI: 10.1016/J.Cell.2011.02.029 |
0.381 |
|
| 2011 |
Zheng M, Wang YH, Wu XN, Wu SQ, Lu BJ, Dong MQ, Zhang H, Sun P, Lin SC, Guan KL, Han J. Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nature Cell Biology. 13: 263-72. PMID 21336308 DOI: 10.1038/Ncb2168 |
0.511 |
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| 2011 |
Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nature Cell Biology. 13: 132-41. PMID 21258367 DOI: 10.1038/Ncb2152 |
0.539 |
|
| 2011 |
Hallows WC, Yu W, Smith BC, Devries MK, Devires MK, Ellinger JJ, Someya S, Shortreed MR, Prolla T, Markley JL, Smith LM, Zhao S, Guan KL, Denu JM. Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Molecular Cell. 41: 139-49. PMID 21255725 DOI: 10.1016/J.Molcel.2011.01.002 |
0.578 |
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| 2011 |
Zhao B, Li L, Lu Q, Wang LH, Liu CY, Lei Q, Guan KL. Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes & Development. 25: 51-63. PMID 21205866 DOI: 10.1101/Gad.2000111 |
0.56 |
|
| 2011 |
Liu CY, Lv X, Li T, Xu Y, Zhou X, Zhao S, Xiong Y, Lei QY, Guan KL. PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ. The Journal of Biological Chemistry. 286: 5558-66. PMID 21189257 DOI: 10.1074/Jbc.M110.194019 |
0.428 |
|
| 2010 |
Zhao B, Li L, Guan KL. Hippo signaling at a glance. Journal of Cell Science. 123: 4001-6. PMID 21084559 DOI: 10.1242/Jcs.069070 |
0.413 |
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| 2010 |
Liu CY, Zha ZY, Zhou X, Zhang H, Huang W, Zhao D, Li T, Chan SW, Lim CJ, Hong W, Zhao S, Xiong Y, Lei QY, Guan KL. The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase. The Journal of Biological Chemistry. 285: 37159-69. PMID 20858893 DOI: 10.1074/Jbc.M110.152942 |
0.335 |
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| 2010 |
Wang C, Yoo Y, Fan H, Kim E, Guan KL, Guan JL. Regulation of Integrin β 1 recycling to lipid rafts by Rab1a to promote cell migration. The Journal of Biological Chemistry. 285: 29398-405. PMID 20639577 DOI: 10.1074/Jbc.M110.141440 |
0.385 |
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| 2010 |
Lian I, Kim J, Okazawa H, Zhao J, Zhao B, Yu J, Chinnaiyan A, Israel MA, Goldstein LS, Abujarour R, Ding S, Guan KL. The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes & Development. 24: 1106-18. PMID 20516196 DOI: 10.1101/Gad.1903310 |
0.404 |
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| 2010 |
Li L, Kim E, Yuan H, Inoki K, Goraksha-Hicks P, Schiesher RL, Neufeld TP, Guan KL. Regulation of mTORC1 by the Rab and Arf GTPases. The Journal of Biological Chemistry. 285: 19705-9. PMID 20457610 DOI: 10.1074/Jbc.C110.102483 |
0.421 |
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| 2010 |
Zhao B, Li L, Lei Q, Guan KL. The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. Genes & Development. 24: 862-74. PMID 20439427 DOI: 10.1101/Gad.1909210 |
0.578 |
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| 2010 |
Alexander A, Cai SL, Kim J, Nanez A, Sahin M, MacLean KH, Inoki K, Guan KL, Shen J, Person MD, Kusewitt D, Mills GB, Kastan MB, Walker CL. ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proceedings of the National Academy of Sciences of the United States of America. 107: 4153-8. PMID 20160076 DOI: 10.1073/Pnas.0913860107 |
0.327 |
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| 2010 |
Li Z, Zhao B, Wang P, Chen F, Dong Z, Yang H, Guan KL, Xu Y. Structural insights into the YAP and TEAD complex. Genes & Development. 24: 235-40. PMID 20123905 DOI: 10.1101/Gad.1865810 |
0.466 |
|
| 2010 |
Zhao B, Li L, Tumaneng K, Wang CY, Guan KL. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP). Genes & Development. 24: 72-85. PMID 20048001 DOI: 10.1101/Gad.1843810 |
0.543 |
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| 2010 |
Alexander A, Cai S, Kim J, Nanez A, Sahin M, MacLean KH, Inoki K, Guan K, Shen J, Person MD, Kusewitt D, Mills GB, Kastan MB, Walker CL. Abstract 4831: ATM signals to TSC2 in the cytoplasm to regulate mTORC1 and autophagy in response to ROS Cancer Research. 70: 4831-4831. DOI: 10.1158/1538-7445.Am10-4831 |
0.473 |
|
| 2009 |
Zhao B, Lei Q, Guan KL. Mst out and HCC in. Cancer Cell. 16: 363-4. PMID 19878866 DOI: 10.1016/J.Ccr.2009.10.008 |
0.468 |
|
| 2009 |
Li L, Guan KL. Amino Acid Signaling to TOR Activation: Vam6 Functioning as a Gtr1 GEF Molecular Cell. 35: 543-545. PMID 19748348 DOI: 10.1016/J.Molcel.2009.08.010 |
0.347 |
|
| 2009 |
Zhou X, Ikenoue T, Chen X, Li L, Inoki K, Guan KL. Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy. Proceedings of the National Academy of Sciences of the United States of America. 106: 8923-8. PMID 19458266 DOI: 10.1073/pnas.0903621106 |
0.332 |
|
| 2009 |
Zhang H, Liu CY, Zha ZY, Zhao B, Yao J, Zhao S, Xiong Y, Lei QY, Guan KL. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. The Journal of Biological Chemistry. 284: 13355-62. PMID 19324877 DOI: 10.1074/Jbc.M900843200 |
0.463 |
|
| 2009 |
Zhao B, Lei QY, Guan KL. Harness the power: new insights into the inhibition of YAP/Yorkie. Developmental Cell. 16: 321-2. PMID 19289076 DOI: 10.1016/J.Devcel.2009.02.015 |
0.46 |
|
| 2009 |
Kim E, Guan KL. RAG GTPases in nutrient-mediated TOR signaling pathway. Cell Cycle (Georgetown, Tex.). 8: 1014-8. PMID 19270521 DOI: 10.4161/Cc.8.7.8124 |
0.441 |
|
| 2009 |
Zhao B, Kim J, Ye X, Lai ZC, Guan KL. Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein. Cancer Research. 69: 1089-98. PMID 19141641 DOI: 10.1158/0008-5472.Can-08-2997 |
0.529 |
|
| 2008 |
Zhao B, Lei QY, Guan KL. The Hippo-YAP pathway: new connections between regulation of organ size and cancer. Current Opinion in Cell Biology. 20: 638-46. PMID 18955139 DOI: 10.1016/J.Ceb.2008.10.001 |
0.549 |
|
| 2008 |
Chen C, Liu Y, Liu R, Ikenoue T, Guan KL, Liu Y, Zheng P. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. The Journal of Experimental Medicine. 205: 2397-408. PMID 18809716 DOI: 10.1084/Jem.20081297 |
0.357 |
|
| 2008 |
Ikenoue T, Inoki K, Zhao B, Guan KL. PTEN acetylation modulates its interaction with PDZ domain. Cancer Research. 68: 6908-12. PMID 18757404 DOI: 10.1158/0008-5472.Can-08-1107 |
0.366 |
|
| 2008 |
Cao C, Lu S, Kivlin R, Wallin B, Card E, Bagdasarian A, Tamakloe T, Chu WM, Guan KL, Wan Y. AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes. The Journal of Biological Chemistry. 283: 28897-908. PMID 18715874 DOI: 10.1074/Jbc.M804144200 |
0.421 |
|
| 2008 |
Kim E, Goraksha-Hicks P, Li L, Neufeld TP, Guan KL. Regulation of TORC1 by Rag GTPases in nutrient response. Nature Cell Biology. 10: 935-45. PMID 18604198 DOI: 10.1038/Ncb1753 |
0.329 |
|
| 2008 |
Zhao B, Ye X, Yu J, Li L, Li W, Li S, Yu J, Lin JD, Wang CY, Chinnaiyan AM, Lai ZC, Guan KL. TEAD mediates YAP-dependent gene induction and growth control. Genes & Development. 22: 1962-71. PMID 18579750 DOI: 10.1101/Gad.1664408 |
0.454 |
|
| 2008 |
Ikenoue T, Inoki K, Yang Q, Zhou X, Guan KL. Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. The Embo Journal. 27: 1919-31. PMID 18566587 DOI: 10.1038/emboj.2008.119 |
0.376 |
|
| 2008 |
Zhao S, Guan KL. Substrate selectivity APPLies to Akt. Cell. 133: 399-400. PMID 18455980 DOI: 10.1016/J.Cell.2008.04.015 |
0.464 |
|
| 2008 |
Lei QY, Zhang H, Zhao B, Zha ZY, Bai F, Pei XH, Zhao S, Xiong Y, Guan KL. TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. Molecular and Cellular Biology. 28: 2426-36. PMID 18227151 DOI: 10.1128/Mcb.01874-07 |
0.503 |
|
| 2007 |
Zhao B, Wei X, Li W, Udan RS, Yang Q, Kim J, Xie J, Ikenoue T, Yu J, Li L, Zheng P, Ye K, Chinnaiyan A, Halder G, Lai ZC, Guan KL, et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes & Development. 21: 2747-61. PMID 17974916 DOI: 10.1101/Gad.1602907 |
0.504 |
|
| 2007 |
Li Y, Wang Y, Kim E, Beemiller P, Wang CY, Swanson J, You M, Guan KL. Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb. The Journal of Biological Chemistry. 282: 35803-13. PMID 17928295 DOI: 10.1074/Jbc.M705231200 |
0.368 |
|
| 2007 |
Yang Q, Guan KL. Expanding mTOR signaling Cell Research. 17: 666-681. PMID 17680028 DOI: 10.1038/Cr.2007.64 |
0.485 |
|
| 2007 |
Lee CH, Inoki K, Guan KL. mTOR pathway as a target in tissue hypertrophy. Annual Review of Pharmacology and Toxicology. 47: 443-67. PMID 16968213 DOI: 10.1146/annurev.pharmtox.47.120505.105359 |
0.357 |
|
| 2006 |
Yang Q, Inoki K, Ikenoue T, Guan KL. Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes & Development. 20: 2820-32. PMID 17043309 DOI: 10.1101/gad.1461206 |
0.399 |
|
| 2006 |
Wan M, Wu X, Guan KL, Han M, Zhuang Y, Xu T. Muscle atrophy in transgenic mice expressing a human TSC1 transgene. Febs Letters. 580: 5621-7. PMID 16996505 DOI: 10.1016/J.Febslet.2006.09.008 |
0.338 |
|
| 2006 |
Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, Yang Q, Bennett C, Harada Y, Stankunas K, Wang CY, He X, MacDougald OA, You M, Williams BO, Guan KL, et al. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell. 126: 955-68. PMID 16959574 DOI: 10.1016/J.Cell.2006.06.055 |
0.418 |
|
| 2006 |
Yang Q, Inoki K, Kim E, Guan KL. TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity. Proceedings of the National Academy of Sciences of the United States of America. 103: 6811-6. PMID 16627617 DOI: 10.1073/pnas.0602282103 |
0.384 |
|
| 2006 |
Inoki K, Guan KL. Complexity of the TOR signaling network Trends in Cell Biology. 16: 206-212. PMID 16516475 DOI: 10.1016/j.tcb.2006.02.002 |
0.379 |
|
| 2006 |
Li W, Aurandt J, Jürgensen C, Jürgense C, Rao Y, Guan KL. FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5. Journal of Cell Science. 119: 47-55. PMID 16371650 DOI: 10.1242/Jcs.02697 |
0.427 |
|
| 2006 |
Aurandt J, Li W, Guan KL. Semaphorin 4D activates the MAPK pathway downstream of plexin-B1. The Biochemical Journal. 394: 459-64. PMID 16187944 DOI: 10.1042/Bj20051123 |
0.434 |
|
| 2005 |
Li Y, Inoki K, Vikis H, Guan KL. Measurements of TSC2 GAP Activity Toward Rheb Methods in Enzymology. 407: 46-54. PMID 16757313 DOI: 10.1016/S0076-6879(05)07005-9 |
0.348 |
|
| 2005 |
Kruger RP, Aurandt J, Guan KL. Semaphorins command cells to move. Nature Reviews. Molecular Cell Biology. 6: 789-800. PMID 16314868 DOI: 10.1038/Nrm1740 |
0.411 |
|
| 2005 |
Gan B, Melkoumian ZK, Wu X, Guan KL, Guan JL. Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control. The Journal of Cell Biology. 170: 379-89. PMID 16043512 DOI: 10.1083/Jcb.200411106 |
0.368 |
|
| 2005 |
Lee J, Li W, Guan KL. SRC-1 mediates UNC-5 signaling in Caenorhabditis elegans. Molecular and Cellular Biology. 25: 6485-95. PMID 16024786 DOI: 10.1128/Mcb.25.15.6485-6495.2005 |
0.428 |
|
| 2005 |
Inoki K, Ouyang H, Li Y, Guan KL. Signaling by target of rapamycin proteins in cell growth control. Microbiology and Molecular Biology Reviews : Mmbr. 69: 79-100. PMID 15755954 DOI: 10.1128/Mmbr.69.1.79-100.2005 |
0.427 |
|
| 2005 |
Yu Y, Li S, Xu X, Li Y, Guan K, Arnold E, Ding J. Structural basis for the unique biological function of small GTPase RHEB. The Journal of Biological Chemistry. 280: 17093-100. PMID 15728574 DOI: 10.1074/Jbc.M501253200 |
0.351 |
|
| 2005 |
Corradetti MN, Inoki K, Guan KL. The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. The Journal of Biological Chemistry. 280: 9769-72. PMID 15632201 DOI: 10.1074/Jbc.C400557200 |
0.404 |
|
| 2005 |
Inoki K, Corradetti MN, Guan KL. Dysregulation of the TSC-mTOR pathway in human disease. Nature Genetics. 37: 19-24. PMID 15624019 DOI: 10.1038/Ng1494 |
0.362 |
|
| 2004 |
Kruger RP, Lee J, Li W, Guan KL. Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10826-34. PMID 15574733 DOI: 10.1523/Jneurosci.3715-04.2004 |
0.31 |
|
| 2004 |
Li Y, Inoki K, Guan KL. Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. Molecular and Cellular Biology. 24: 7965-75. PMID 15340059 DOI: 10.1128/MCB.24.18.7965-7975.2004 |
0.347 |
|
| 2004 |
Basile JR, Barac A, Zhu T, Guan KL, Gutkind JS. Class IV semaphorins promote angiogenesis by stimulating Rho-initiated pathways through plexin-B. Cancer Research. 64: 5212-24. PMID 15289326 DOI: 10.1158/0008-5472.Can-04-0126 |
0.391 |
|
| 2004 |
Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes & Development. 18: 1533-8. PMID 15231735 DOI: 10.1101/Gad.1199104 |
0.309 |
|
| 2004 |
Li W, Zhu T, Guan K. Transformation Potential of Ras Isoforms Correlates with Activation of Phosphatidylinositol 3-Kinase but Not ERK Journal of Biological Chemistry. 279: 37398-37406. PMID 15210703 DOI: 10.1074/Jbc.M405730200 |
0.378 |
|
| 2004 |
Xie S, Wang Q, Ruan Q, Liu T, Jhanwar-Uniyal M, Guan K, Dai W. MEK1-induced Golgi dynamics during cell cycle progression is partly mediated by Polo-like kinase-3. Oncogene. 23: 3822-9. PMID 15021912 DOI: 10.1038/Sj.Onc.1207479 |
0.496 |
|
| 2004 |
Ruan Q, Wang Q, Xie S, Fang Y, Darzynkiewicz Z, Guan K, Jhanwar-Uniyal M, Dai W. Polo-like kinase 3 is Golgi localized and involved in regulating Golgi fragmentation during the cell cycle. Experimental Cell Research. 294: 51-9. PMID 14980500 DOI: 10.1016/J.Yexcr.2003.10.022 |
0.491 |
|
| 2004 |
Yang F, Yamashita J, Tang E, Wang HL, Guan K, Wang CY. The zinc finger mutation C417R of I-kappa B kinase gamma impairs lipopolysaccharide- and TNF-mediated NF-kappa B activation through inhibiting phosphorylation of the I-kappa B kinase beta activation loop. Journal of Immunology (Baltimore, Md. : 1950). 172: 2446-52. PMID 14764716 DOI: 10.4049/Jimmunol.172.4.2446 |
0.361 |
|
| 2004 |
Li Y, Corradetti MN, Inoki K, Guan KL. TSC2: filling the GAP in the mTOR signaling pathway. Trends in Biochemical Sciences. 29: 32-8. PMID 14729330 DOI: 10.1016/J.Tibs.2003.11.007 |
0.352 |
|
| 2004 |
Yoder JH, Chong H, Guan KL, Han M. Modulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphatase. The Embo Journal. 23: 111-9. PMID 14685271 DOI: 10.1038/Sj.Emboj.7600025 |
0.352 |
|
| 2004 |
Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell. 115: 577-90. PMID 14651849 DOI: 10.1016/s0092-8674(03)00929-2 |
0.359 |
|
| 2003 |
Guan KL, Rao Y. Signalling mechanisms mediating neuronal responses to guidance cues. Nature Reviews. Neuroscience. 4: 941-56. PMID 14682358 DOI: 10.1038/Nrn1254 |
0.358 |
|
| 2003 |
Tang ED, Inohara N, Wang CY, Nuñez G, Guan KL. Roles for homotypic interactions and transautophosphorylation in IkappaB kinase beta IKKbeta) activation [corrected]. The Journal of Biological Chemistry. 278: 38566-70. PMID 12890679 DOI: 10.1074/Jbc.M304374200 |
0.439 |
|
| 2003 |
Inoki K, Li Y, Xu T, Guan KL. Rheb GTpase is a direct target of TSC2 GAP activity and regulates mTOR signaling Genes and Development. 17: 1829-1834. PMID 12869586 DOI: 10.1101/gad.1110003 |
0.411 |
|
| 2003 |
Tang ED, Wang CY, Xiong Y, Guan KL. A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha. The Journal of Biological Chemistry. 278: 37297-305. PMID 12867425 DOI: 10.1074/Jbc.M303389200 |
0.378 |
|
| 2003 |
Hurley JH, Zhang S, Bye LS, Marshall MS, DePaoli-Roach AA, Guan K, Fox AP, Yu L. Insulin signaling inhibits the 5-HT2C receptor in choroid plexus via MAP kinase. Bmc Neuroscience. 4: 10. PMID 12795815 DOI: 10.1186/1471-2202-4-10 |
0.41 |
|
| 2003 |
Yang F, Tang E, Guan K, Wang CY. IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide. Journal of Immunology (Baltimore, Md. : 1950). 170: 5630-5. PMID 12759443 DOI: 10.4049/Jimmunol.170.11.5630 |
0.368 |
|
| 2003 |
Li Y, Inoki K, Vacratsis P, Guan KL. The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3. The Journal of Biological Chemistry. 278: 13663-71. PMID 12582162 DOI: 10.1074/Jbc.M300862200 |
0.334 |
|
| 2002 |
Vikis H, Guan KL. Regulation of the Ras-MAPK pathway at the level of Ras and Raf Genetic Engineering. 24: 49-66. PMID 12416300 DOI: 10.1007/978-1-4615-0721-5_3 |
0.467 |
|
| 2002 |
Li Y, Inoki K, Yeung R, Guan KL. Regulation of TSC2 by 14-3-3 binding. The Journal of Biological Chemistry. 277: 44593-6. PMID 12364343 DOI: 10.1074/JBC.C200510200 |
0.369 |
|
| 2002 |
Aurandt J, Vikis HG, Gutkind JS, Ahn N, Guan KL. The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG Proceedings of the National Academy of Sciences of the United States of America. 99: 12085-12090. PMID 12196628 DOI: 10.1073/Pnas.142433199 |
0.333 |
|
| 2002 |
Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nature Cell Biology. 4: 648-57. PMID 12172553 DOI: 10.1038/Ncb839 |
0.401 |
|
| 2002 |
Vikis HG, Stewart S, Guan K. SmgGDS displays differential binding and exchange activity towards different Ras isoforms. Oncogene. 21: 2425-2432. PMID 11948427 DOI: 10.1038/Sj.Onc.1205306 |
0.331 |
|
| 2002 |
Vikis HG, Li W, Guan KL. The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding. Genes & Development. 16: 836-45. PMID 11937491 DOI: 10.1101/Gad.966402 |
0.339 |
|
| 2002 |
Lu C, Li Y, Zhao Y, Xing G, Tang F, Wang Q, Sun Y, Wei H, Yang X, Wu C, Chen J, Guan KL, Zhang C, Chen H, He F. Intracrine hepatopoietin potentiates AP-1 activity through JAB1 independent of MAPK pathway. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 90-2. PMID 11709497 DOI: 10.1096/Fj.01-0506Fje |
0.369 |
|
| 2001 |
Zhan XL, Wishart MJ, Guan KL. Nonreceptor tyrosine phosphatases in cellular signaling: regulation of mitogen-activated protein kinases. Chemical Reviews. 101: 2477-96. PMID 11749384 DOI: 10.1021/cr000245u |
0.396 |
|
| 2001 |
Chen S, Guttridge DC, Tang E, Shi S, Guan K, Wang C. Suppression of Tumor Necrosis Factor-mediated Apoptosis by Nuclear Factor κB-independent Bone Morphogenetic Protein/Smad Signaling Journal of Biological Chemistry. 276: 39259-39263. PMID 11500509 DOI: 10.1074/Jbc.M105335200 |
0.429 |
|
| 2001 |
Chong H, Lee J, Guan KL. Positive and negative regulation of Raf kinase activity and function by phosphorylation. The Embo Journal. 20: 3716-27. PMID 11447113 DOI: 10.1093/Emboj/20.14.3716 |
0.334 |
|
| 2001 |
Zhang BH, Tang ED, Zhu T, Greenberg ME, Vojtek AB, Guan KL. Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf. The Journal of Biological Chemistry. 276: 31620-6. PMID 11410590 DOI: 10.1074/Jbc.M102808200 |
0.343 |
|
| 2001 |
Zhang BH, Guan KL. Regulation of the Raf kinase by phosphorylation Experimental Lung Research. 27: 269-295. PMID 11293329 DOI: 10.1080/019021401300054046 |
0.45 |
|
| 2001 |
Vikis HG, Li W, He Z, Guan KL. The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner. Proceedings of the National Academy of Sciences of the United States of America. 97: 12457-62. PMID 11035813 DOI: 10.1073/Pnas.220421797 |
0.339 |
|
| 2001 |
Li Y, Li M, Xing G, Hu Z, Wang Q, Dong C, Wei H, Fan G, Chen J, Yang X, Zhao S, Chen H, Guan K, Wu C, Zhang C, et al. Stimulation of the mitogen-activated protein kinase cascade and tyrosine phosphorylation of the epidermal growth factor receptor by hepatopoietin. The Journal of Biological Chemistry. 275: 37443-7. PMID 10982794 DOI: 10.1074/Jbc.M004373200 |
0.43 |
|
| 2000 |
Zhang BH, Guan KL. Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601 Embo Journal. 19: 5429-5439. PMID 11032810 DOI: 10.1093/Emboj/19.20.5429 |
0.414 |
|
| 2000 |
Simon AR, Vikis HG, Stewart S, Fanburg BL, Cochran BH, Guan KL. Regulation of STAT3 by direct binding to the Rac1 GTPase. Science (New York, N.Y.). 290: 144-7. PMID 11021801 DOI: 10.1126/Science.290.5489.144 |
0.477 |
|
| 2000 |
Stewart S, Guan KL. The dominant negative Ras mutant, N17Ras, can inhibit signaling independently of blocking ras activation Journal of Biological Chemistry. 275: 8854-8862. PMID 10722731 DOI: 10.1074/Jbc.275.12.8854 |
0.433 |
|
| 2000 |
Zhan XL, Hong Y, Zhu T, Mitchell AP, Deschenes RJ, Guan KL. Essential functions of protein tyrosine phosphatases PTP2 and PTP3 and RIM11 tyrosine phosphorylation in Saccharomyces cerevisiae meiosis and sporulation. Molecular Biology of the Cell. 11: 663-76. PMID 10679022 DOI: 10.1091/Mbc.11.2.663 |
0.713 |
|
| 2000 |
Xiao G, Jiang D, Thomas P, Benson MD, Guan K, Karsenty G, Franceschi RT. MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1. The Journal of Biological Chemistry. 275: 4453-9. PMID 10660618 DOI: 10.1074/Jbc.275.6.4453 |
0.499 |
|
| 2000 |
Li W, Han M, Guan K. The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf Genes & Development. 14: 895-900. DOI: 10.1101/Gad.14.8.895 |
0.425 |
|
| 1999 |
Zhan XL, Guan KL. A specific protein-protein interaction accounts for the in vivo substrate selectivity of Ptp3 towards the Fus3 MAP kinase. Genes & Development. 13: 2811-27. PMID 10557209 DOI: 10.1101/Gad.13.21.2811 |
0.4 |
|
| 1999 |
Guan KL, Han M. A G-protein signaling network mediated by an RGS protein Genes and Development. 13: 1763-1767. PMID 10421628 DOI: 10.1101/Gad.13.14.1763 |
0.31 |
|
| 1999 |
Tang ED, Nuñez G, Barr FG, Guan KL. Negative regulation of the forkhead transcription factor FKHR by Akt. The Journal of Biological Chemistry. 274: 16741-6. PMID 10358014 DOI: 10.1074/jbc.274.24.16741 |
0.365 |
|
| 1999 |
Tan M, Li S, Swaroop M, Guan K, Oberley LW, Sun Y. Transcriptional activation of the human glutathione peroxidase promoter by p53. The Journal of Biological Chemistry. 274: 12061-6. PMID 10207030 DOI: 10.1074/Jbc.274.17.12061 |
0.319 |
|
| 1998 |
Hodge C, Liao J, Stofega M, Guan K, Carter-Su C, Schwartz J. Growth hormone stimulates phosphorylation and activation of Elk-1 and expression of c-fos, egr-1, and junB through activation of extracellular signal-regulated kinases 1 and 2 Journal of Biological Chemistry. 273: 31327-31336. PMID 9813041 DOI: 10.1074/Jbc.273.47.31327 |
0.482 |
|
| 1998 |
Goldman D, Sapru MK, Stewart S, Plotkin J, Libermann TA, Wasylyk B, Guan K. Cloning and characterization of GETS-1, a goldfish Ets family member that functions as a transcriptional repressor in muscle Biochemical Journal. 335: 267-275. PMID 9761723 DOI: 10.1042/Bj3350267 |
0.417 |
|
| 1998 |
Sugimoto T, Stewart S, Han M, Guan KL. The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation. The Embo Journal. 17: 1717-27. PMID 9501093 DOI: 10.1093/Emboj/17.6.1717 |
0.443 |
|
| 1997 |
Dabrowski A, Groblewski GE, Schäfer C, Guan KL, Williams JA. Cholecystokinin and EGF activate a MAPK cascade by different mechanisms in rat pancreatic acinar cells. American Journal of Physiology. Cell Physiology. 273: C1472-C1479. PMID 29585032 DOI: 10.1152/Ajpcell.1997.273.5.C1472 |
0.344 |
|
| 1997 |
Sugimoto T, Stewart S, Guan KL. The calcium/calmodulin-dependent protein phosphatase calcineurin is the major Elk-1 phosphatase. The Journal of Biological Chemistry. 272: 29415-8. PMID 9367995 DOI: 10.1074/Jbc.272.47.29415 |
0.522 |
|
| 1997 |
Syu LJ, Guan KL, Saltiel AR. Inducible expression of a mutant form of MEK1 in Swiss 3T3 cells. Journal of Cellular Biochemistry. 67: 367-77. PMID 9361191 DOI: 10.1002/(Sici)1097-4644(19971201)67:3<367::Aid-Jcb8>3.0.Co;2-U |
0.309 |
|
| 1997 |
Vanderkuur JA, Butch ER, Waters SB, Pessin JE, Guan KL, Carter-Su C. Signaling molecules involved in coupling growth hormone receptor to mitogen-activated protein kinase activation Endocrinology. 138: 4301-4307. PMID 9322943 DOI: 10.1210/Endo.138.10.5453 |
0.357 |
|
| 1997 |
Zhan XL, Deschenes RJ, Guan KL. Differential regulation of FUS3 MAP kinase by tyrosine-specific phosphatases PTP2/PTP3 and dual-specificity phosphatase MSG5 in Saccharomyces cerevisiae. Genes & Development. 11: 1690-702. PMID 9224718 DOI: 10.1101/Gad.11.13.1690 |
0.696 |
|
| 1997 |
Gorgas G, Butch ER, Guan K, Miller RA. Diminished activation of the MAP kinase pathway in CD3-stimulated T lymphocytes from old mice. Mechanisms of Ageing and Development. 94: 71-83. PMID 9147361 DOI: 10.1016/S0047-6374(96)01857-X |
0.444 |
|
| 1997 |
Gupta AK, Lee YJ, Galoforo SS, Berns CM, Martinez AA, Corry PM, Wu X, Guan K. Differential effect of glucose deprivation on MAPK activation in drug sensitive human breast carcinoma MCF-7 and multidrug resistant MCF-7/ADR cells Molecular and Cellular Biochemistry. 170: 23-30. PMID 9144315 DOI: 10.1023/A:1006890316102 |
0.372 |
|
| 1997 |
Jiang Y, Li Z, Schwarz EM, Lin A, Guan K, Ulevitch RJ, Han J. Structure-function studies of p38 mitogen-activated protein kinase. Loop 12 influences substrate specificity and autophosphorylation, but not upstream kinase selection. The Journal of Biological Chemistry. 272: 11096-102. PMID 9111004 DOI: 10.1074/Jbc.272.17.11096 |
0.399 |
|
| 1996 |
Butch ER, Guan KL. Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2 Journal of Biological Chemistry. 271: 4230-4235. PMID 8626767 DOI: 10.1074/Jbc.271.8.4230 |
0.429 |
|
| 1996 |
Wu X, Noh SJ, Zhou G, Dixon JE, Guan KL. Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells. The Journal of Biological Chemistry. 271: 3265-71. PMID 8621729 DOI: 10.1074/Jbc.271.6.3265 |
0.624 |
|
| 1996 |
Sugimoto T, Haneda M, Togawa M, Isono M, Shikano T, Araki S, Nakagawa T, Kashiwagi A, Guan KL, Kikkawa R. Atrial natriuretic peptide induces the expression of MKP-1, a mitogen-activated protein kinase phosphatase, in glomerular mesangial cells. The Journal of Biological Chemistry. 271: 544-7. PMID 8550616 DOI: 10.1074/Jbc.271.1.544 |
0.465 |
|
| 1995 |
Pang L, Zheng CF, Guan KL, Saltiel AR. Nerve growth factor stimulates a novel protein kinase in PC-12 cells that phosphorylates and activates mitogen-activated protein kinase kinase (MEK) Biochemical Journal. 307: 513-519. PMID 7733891 DOI: 10.1042/Bj3070513 |
0.438 |
|
| 1995 |
Kornfeld K, Guan KL, Horvitz HR. The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK. Genes & Development. 9: 756-68. PMID 7729691 DOI: 10.1101/Gad.9.6.756 |
0.302 |
|
| 1995 |
Wu Y, Han M, Guan KL. MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events. Genes & Development. 9: 742-55. PMID 7729690 DOI: 10.1101/Gad.9.6.742 |
0.42 |
|
| 1995 |
Zhang ZY, Zhou G, Denu JM, Wu L, Tang X, Mondesert O, Russell P, Butch E, Guan KL. Purification and characterization of the low molecular weight protein tyrosine phosphatase, Stp1, from the fission yeast Schizosaccharomyces pombe. Biochemistry. 34: 10560-8. PMID 7654712 DOI: 10.1021/Bi00033A031 |
0.514 |
|
| 1995 |
Wang QM, Guan KL, Roach PJ, DePaoli-Roach AA. Phosphorylation and activation of the ATP-Mg-dependent protein phosphatase by the mitogen-activated protein kinase Journal of Biological Chemistry. 270: 18352-18358. PMID 7629158 DOI: 10.1074/Jbc.270.31.18352 |
0.439 |
|
| 1995 |
Duan RD, Zheng CF, Guan KL, Williams JA. Activation of MAP kinase kinase (MEK) and Ras by cholecystokinin in rat pancreatic acini. The American Journal of Physiology. 268: G1060-5. PMID 7611406 DOI: 10.1152/Ajpgi.1995.268.6.G1060 |
0.402 |
|
| 1995 |
Guan KL, Butch E. Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase Journal of Biological Chemistry. 270: 7197-7203. PMID 7535768 DOI: 10.1074/Jbc.270.13.7197 |
0.506 |
|
| 1994 |
Zheng CF, Ohmichi M, Saltiel AR, Guan KL. Growth factor induced MEK activation is primarily mediated by an activator different from c-raf Biochemistry. 33: 5595-5599. PMID 8180183 DOI: 10.1021/Bi00184A031 |
0.332 |
|
| 1994 |
Frost JA, Alberts AS, Sontag E, Guan K, Mumby MC, Feramisco JR. Simian virus 40 small t antigen cooperates with mitogen-activated kinases to stimulate AP-1 activity. Molecular and Cellular Biology. 14: 6244-52. PMID 8065356 DOI: 10.1128/Mcb.14.9.6244 |
0.419 |
|
| 1994 |
Zheng C, Guan K. Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues. The Embo Journal. 13: 1123-1131. DOI: 10.1002/J.1460-2075.1994.Tb06361.X |
0.455 |
|
| 1993 |
Guan K, Hakes D, Dixon JE, Park HD, Cooper TG. The yeast open reading frame encoding a dual specificity phosphatase. Trends in Biochemical Sciences. 18: 6. PMID 8438236 DOI: 10.1016/0968-0004(93)90079-3 |
0.485 |
|
| 1993 |
Guan KL, Dixon JE. Bacterial and viral protein tyrosine phosphatases. Seminars in Cell Biology. 4: 389-96. PMID 8305677 DOI: 10.1006/Scel.1993.1046 |
0.606 |
|
| 1993 |
Guan K, Farh L, Marshall TK, Deschenes RJ. Normal mitochondrial structure and genome maintenance in yeast requires the dynamin-like product of the MGM1 gene Current Genetics. 24: 141-148. PMID 7916673 DOI: 10.1007/Bf00324678 |
0.624 |
|
| 1993 |
Guan K, Hakes DJ, Wang Y, Park HD, Cooper TG, Dixon JE. A yeast protein phosphatase related to the vaccinia virus VH1 phosphatase is induced by nitrogen starvation. Proceedings of the National Academy of Sciences of the United States of America. 89: 12175-9. PMID 1334559 DOI: 10.1073/Pnas.89.24.12175 |
0.533 |
|
| 1992 |
Millar JB, Russell P, Dixon JE, Guan KL. Negative regulation of mitosis by two functionally overlapping PTPases in fission yeast. The Embo Journal. 11: 4943-52. PMID 1464319 DOI: 10.1002/J.1460-2075.1992.Tb05601.X |
0.572 |
|
| 1991 |
Ni L, Guan K, Zalkin H, Dixon JE. De novo purine nucleotide biosynthesis: cloning, sequencing and expression of a chicken PurH cDNA encoding 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase-IMP cyclohydrolase Gene. 106: 197-205. PMID 1937050 DOI: 10.1016/0378-1119(91)90199-L |
0.485 |
|
| 1991 |
Guan KL, Dixon JE. Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase. Analytical Biochemistry. 192: 262-7. PMID 1852137 DOI: 10.1016/0003-2697(91)90534-Z |
0.493 |
|
| 1991 |
Guan KL, Broyles SS, Dixon JE. A Tyr/Ser protein phosphatase encoded by vaccinia virus. Nature. 350: 359-62. PMID 1848923 DOI: 10.1038/350359A0 |
0.576 |
|
| 1991 |
Clemens JC, Guan K, Bliska JB, Falkow S, Dixon JE. Microbial pathogenesis and tyrosine dephosphorylation: surprising 'bedfellows'. Molecular Microbiology. 5: 2617-20. PMID 1723471 DOI: 10.1111/J.1365-2958.1991.Tb01970.X |
0.549 |
|
| 1991 |
Bliska JB, Guan KL, Dixon JE, Falkow S. Tyrosine phosphate hydrolysis of host proteins by an essential Yersinia virulence determinant. Proceedings of the National Academy of Sciences of the United States of America. 88: 1187-91. PMID 1705028 DOI: 10.1073/Pnas.88.4.1187 |
0.496 |
|
| 1991 |
Guan KL, Dixon JE. Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediate. The Journal of Biological Chemistry. 266: 17026-30. PMID 1654322 |
0.43 |
|
| 1991 |
Guan KL, Deschenes RJ, Qiu H, Dixon JE. Cloning and expression of a yeast protein tyrosine phosphatase. The Journal of Biological Chemistry. 266: 12964-70. PMID 1649172 |
0.694 |
|
| 1990 |
Guan KL, Dixon JE. Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia. Science (New York, N.Y.). 249: 553-6. PMID 2166336 DOI: 10.1126/Science.2166336 |
0.563 |
|
| 1990 |
Guan KL, Haun RS, Watson SJ, Geahlen RL, Dixon JE. Cloning and expression of a protein-tyrosine-phosphatase. Proceedings of the National Academy of Sciences of the United States of America. 87: 1501-5. PMID 2154749 DOI: 10.1073/Pnas.87.4.1501 |
0.516 |
|
| 1990 |
Guan K, Weiner H. Sequence of the precursor of bovine liver mitochondrial aldehyde dehydrogenase as determined from its cDNA, its gene, and its functionality Archives of Biochemistry and Biophysics. 277: 351-360. PMID 1689984 DOI: 10.1016/0003-9861(90)90590-U |
0.309 |
|
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