Peter J. Ratcliffe - Publications

Affiliations: 
University of Oxford, Oxford, United Kingdom 
Area:
hypoxia biology
Website:
https://www.magd.ox.ac.uk/member-of-staff/peter-ratcliffe/

230 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Ortmann BM, Burrows N, Lobb IT, Arnaiz E, Wit N, Bailey PSJ, Jordon LH, Lombardi O, Peñalver A, McCaffrey J, Seear R, Mole DR, Ratcliffe PJ, Maxwell PH, Nathan JA. The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes. Nature Genetics. PMID 34155378 DOI: 10.1038/s41588-021-00887-y  0.305
2020 Hodson E, Ratcliffe PJ. Endothelial Oxygen Sensing in Alveolar Maintenance. American Journal of Respiratory and Critical Care Medicine. 202: 917-919. PMID 32668176 DOI: 10.1164/Rccm.202006-2149Ed  0.339
2020 Cheng X, Prange-Barczynska M, Fielding JW, Zhang M, Burrell AL, Lima JD, Eckardt L, Argles I, Pugh CW, Buckler KJ, Robbins PA, Hodson EJ, Bruick RK, Collinson LM, Rastinejad F, ... ... Ratcliffe PJ, et al. Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control. The Journal of Clinical Investigation. PMID 31999648 DOI: 10.1172/Jci133194  0.378
2020 Bishop T, Ratcliffe PJ. Genetic basis of oxygen sensing in the carotid body: HIF2α and an isoform switch in cytochrome c oxidase subunit 4. Science Signaling. 13. PMID 31964803 DOI: 10.1126/Scisignal.Aba1302  0.385
2019 Schmid V, Lafleur VN, Lombardi O, Li R, Salama R, Colli L, Choudhry H, Chanock S, Ratcliffe PJ, Mole DR. Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer. Scientific Reports. 9: 18768. PMID 31822727 DOI: 10.1038/S41598-019-55098-7  0.332
2019 Holt-Martyn J, Chowdhury R, Tumber A, Yeh TL, Abboud MI, Lippl K, Lohans C, Langley G, McDonough M, Pugh C, Ratcliffe P, Schofield C. Structure-Activity Relationship and Crystallographic Studies On 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors. Chemmedchem. PMID 31751494 DOI: 10.1002/Cmdc.201900557  0.314
2019 Lauer V, Grampp S, Platt J, Lafleur V, Lombardi O, Choudhry H, Kranz F, Hartmann A, Wullich B, Yamamoto A, Coleman ML, Ratcliffe PJ, Mole DR, Schödel J. Hypoxia drives glucose transporter 3 expression through HIF-mediated induction of the long non-coding RNA NICI. The Journal of Biological Chemistry. PMID 31690629 DOI: 10.1074/Jbc.Ra119.009827  0.39
2019 Cockman ME, Lippl K, Tian YM, Pegg HB, Figg WD, Abboud MI, Heilig R, Fischer R, Myllyharju J, Schofield CJ, Ratcliffe PJ. Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates. Elife. 8. PMID 31500697 DOI: 10.7554/Elife.46490  0.417
2019 Schödel J, Ratcliffe PJ. Mechanisms of hypoxia signalling: new implications for nephrology. Nature Reviews. Nephrology. 15: 641-659. PMID 31488900 DOI: 10.1038/S41581-019-0182-Z  0.48
2019 Masson N, Keeley TP, Giuntoli B, White MD, Puerta ML, Perata P, Hopkinson RJ, Flashman E, Licausi F, Ratcliffe PJ. Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants. Science (New York, N.Y.). 365: 65-69. PMID 31273118 DOI: 10.1126/Science.Aaw0112  0.39
2019 Yamamoto A, Hester J, Macklin PS, Kawai K, Uchiyama M, Biggs D, Bishop T, Bull K, Cheng X, Cawthorne E, Coleman ML, Crockford TL, Davies B, Dow LE, Goldin R, ... ... Ratcliffe PJ, et al. Systemic silencing of PHD2 causes reversible immune regulatory dysfunction. The Journal of Clinical Investigation. 130. PMID 31162141 DOI: 10.1172/Jci124099  0.388
2019 Cockman ME, Lippl K, Tian Y, Pegg HB, Jnr WDF, Abboud MI, Heilig R, Fischer R, Myllyharju J, Schofield CJ, Ratcliffe PJ. Author response: Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates Elife. DOI: 10.7554/Elife.46490.072  0.339
2018 Smythies JA, Sun M, Masson N, Salama R, Simpson PD, Murray E, Neumann V, Cockman ME, Choudhry H, Ratcliffe PJ, Mole DR. Inherent DNA-binding specificities of the HIF-1α and HIF-2α transcription factors in chromatin. Embo Reports. PMID 30429208 DOI: 10.15252/Embr.201846401  0.395
2018 Wang Y, Zhong S, Schofield CJ, Ratcliffe PJ, Lu X. Nuclear entry and export of FIH are mediated by HIF1α and exportin1 respectively. Journal of Cell Science. PMID 30333145 DOI: 10.1242/Jcs.219782  0.416
2018 Fielding JW, Hodson EJ, Cheng X, Ferguson DJP, Eckardt L, Adam J, Lip P, Maton-Howarth M, Ratnayaka I, Pugh CW, Buckler KJ, Ratcliffe PJ, Bishop T. PHD2 inactivation in Type I cells drives HIF-2α dependent multi-lineage hyperplasia and the formation of paraganglioma-like carotid bodies. The Journal of Physiology. PMID 29917232 DOI: 10.1113/Jp275996  0.412
2018 Markolovic S, Zhuang Q, Wilkins SE, Eaton CD, Abboud MI, Katz MJ, McNeil HE, Leśniak RK, Hall C, Struwe WB, Konietzny R, Davis S, Yang M, Ge W, Benesch JLP, ... ... Ratcliffe PJ, et al. The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases. Nature Chemical Biology. 14: 688-695. PMID 29915238 DOI: 10.1038/S41589-018-0071-Y  0.307
2018 Holliday J, Platt S, Handzlik M, MacDonald I, Clarke K, Ratcliffe P, Cole M. T2 Factor inhibiting HIF (FIH1) modulates cardiac function and metabolism Heart. 104. DOI: 10.1136/Heartjnl-2018-Bscr.2  0.392
2018 Ratcliffe PJ. New horizons in hypoxia signaling pathways in health and disease Free Radical Biology and Medicine. 120. DOI: 10.1016/J.Freeradbiomed.2018.04.012  0.42
2017 Yeh TL, Leissing TM, Abboud MI, Thinnes CC, Atasoylu O, Holt-Martyn JP, Zhang D, Tumber A, Lippl K, Lohans CT, Leung IKH, Morcrette H, Clifton IJ, Claridge TDW, Kawamura A, ... ... Ratcliffe PJ, et al. Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. Chemical Science. 8: 7651-7668. PMID 29435217 DOI: 10.1039/C7Sc02103H  0.37
2017 Tiana M, Acosta-Iborra B, Puente-Santamaría L, Hernansanz-Agustin P, Worsley-Hunt R, Masson N, García-Rio F, Mole D, Ratcliffe P, Wasserman WW, Jimenez B, Peso LD. The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia. Nucleic Acids Research. PMID 29059365 DOI: 10.1093/Nar/Gkx951  0.418
2017 Sadiku P, Willson JA, Dickinson RS, Murphy F, Harris AJ, Lewis A, Sammut D, Mirchandani AS, Ryan E, Watts ER, Thompson AAR, Marriott HM, Dockrell DH, Taylor CT, Schneider M, ... ... Ratcliffe PJ, et al. Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses. The Journal of Clinical Investigation. PMID 28805660 DOI: 10.1172/Jci90848  0.325
2017 Grampp S, Schmid V, Salama R, Lauer V, Kranz F, Platt JL, Smythies J, Choudhry H, Goppelt-Struebe M, Ratcliffe PJ, Mole DR, Schödel J. Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway. Plos Genetics. 13: e1006872. PMID 28715484 DOI: 10.1371/Journal.Pgen.1006872  0.378
2017 Ratcliffe P, Koivunen P, Myllyharju J, Ragoussis J, Bovée JV, Batinic-Haberle I, Vinatier C, Trichet V, Robriquet F, Oliver L, Gardie B. Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics. Hypoxia (Auckland, N.Z.). 5: 11-20. PMID 28352643 DOI: 10.2147/Hp.S127042  0.375
2017 Pugh CW, Ratcliffe PJ. New horizons in hypoxia signaling pathways. Experimental Cell Research. 356: 116-121. PMID 28315322 DOI: 10.1016/J.Yexcr.2017.03.008  0.445
2017 Paolini NA, Attwood M, Sondalle SB, Vieira CM, van Adrichem AM, di Summa FM, O'Donohue MF, Gleizes PE, Rachuri S, Briggs JW, Fischer R, Ratcliffe PJ, Wlodarski MW, Houtkooper RH, von Lindern M, et al. A Ribosomopathy Reveals Decoding Defective Ribosomes Driving Human Dysmorphism. American Journal of Human Genetics. 100: 506-522. PMID 28257692 DOI: 10.1016/J.Ajhg.2017.01.034  0.302
2016 Pan J, Bishop T, Ratcliffe PJ, Yeger H, Cutz E. Hyperplasia and hypertrophy of pulmonary neuroepithelial bodies, presumed airway hypoxia sensors, in hypoxia-inducible factor prolyl hydroxylase-deficient mice. Hypoxia (Auckland, N.Z.). 4: 69-80. PMID 27800509 DOI: 10.2147/Hp.S103957  0.36
2016 Grampp S, Platt JL, Lauer V, Salama R, Kranz F, Neumann VK, Wach S, Stöhr C, Hartmann A, Eckardt KU, Ratcliffe PJ, Mole DR, Schödel J. Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer. Nature Communications. 7: 13183. PMID 27774982 DOI: 10.1038/Ncomms13183  0.376
2016 Camps C, Petousi N, Bento C, Cario H, Copley RR, McMullin MF, vanWijk R, Ratcliffe PJ, Robbins PA, Taylor JC. Gene panel sequencing improves the diagnostic work-up of patients with idiopathic erythrocytosis and identifies new mutations. Haematologica. PMID 27651169 DOI: 10.3324/Haematol.2016.144063  0.333
2016 Kaelin WG, Ratcliffe PJ, Semenza GL. Pathways for Oxygen Regulation and Homeostasis: The 2016 Albert Lasker Basic Medical Research Award. Jama. PMID 27622845 DOI: 10.1001/Jama.2016.12386  0.32
2016 Chowdhury R, Leung IK, Tian YM, Abboud MI, Ge W, Domene C, Cantrelle FX, Landrieu I, Hardy AP, Pugh CW, Ratcliffe PJ, Claridge TD, Schofield CJ. Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases. Nature Communications. 7: 12673. PMID 27561929 DOI: 10.1038/Ncomms12673  0.43
2016 Platt JL, Salama R, Smythies J, Choudhry H, Davies JO, Hughes JR, Ratcliffe PJ, Mole DR. Capture-C reveals preformed chromatin interactions between HIF-binding sites and distant promoters. Embo Reports. PMID 27506891 DOI: 10.15252/Embr.201642198  0.398
2016 Chan MC, Ilott NE, Schödel J, Sims D, Tumber A, Lippl K, Mole DR, Pugh CW, Ratcliffe PJ, Ponting CP, Schofield CJ. Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases. The Journal of Biological Chemistry. PMID 27502280 DOI: 10.1074/Jbc.M116.749291  0.462
2016 Frise MC, Cheng HY, Nickol AH, Curtis MK, Pollard KA, Roberts DJ, Ratcliffe PJ, Dorrington KL, Robbins PA. Clinical iron deficiency disturbs normal human responses to hypoxia. The Journal of Clinical Investigation. PMID 27140401 DOI: 10.1172/Jci85715  0.339
2016 Vukovic M, Sepulveda C, Subramani C, Guitart AV, Mohr J, Allen L, Panagopoulou TI, Paris J, Lawson H, Villacreces A, Armesilla-Diaz A, Gezer D, Holyoake TL, Ratcliffe PJ, Kranc KR. Adult haematopoietic stem cells lacking Hif-1α self-renew normally. Blood. PMID 27060169 DOI: 10.1182/Blood-2015-10-677138  0.361
2016 Chan MC, Holt-Martyn JP, Schofield CJ, Ratcliffe PJ. Pharmacological targeting of the HIF hydroxylases - a new field in medicine development. Molecular Aspects of Medicine. PMID 26791432 DOI: 10.1016/J.Mam.2016.01.001  0.431
2016 Schödel J, Grampp S, Maher ER, Moch H, Ratcliffe PJ, Russo P, Mole DR. Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer. European Urology. 69: 646-57. PMID 26298207 DOI: 10.1016/J.Eururo.2015.08.007  0.347
2016 Choudhry H, Albukhari A, Morotti M, Haider S, Moralli D, Schödel J, Green C, Camps C, Buffa F, Ratcliffe P, Ragoussis I, Mole D, Harris A. Abstract A29: Hypoxia regulated long noncoding RNAs and antisense transcripts in breast cancer: Novel insights of noncoding transcriptional regulation in hypoxic microenvironment Cancer Research. 76. DOI: 10.1158/1538-7445.Nonrna15-A29  0.399
2015 Vukovic M, Guitart AV, Sepulveda C, Villacreces A, O'Duibhir E, Panagopoulou TI, Ivens A, Menendez-Gonzalez J, Iglesias JM, Allen L, Glykofrydis F, Subramani C, Armesilla-Diaz A, Post AE, Schaak K, ... ... Ratcliffe PJ, et al. Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance. The Journal of Experimental Medicine. PMID 26642852 DOI: 10.1084/Jem.20150452  0.311
2015 Hodson EJ, Nicholls LG, Turner PJ, Llyr R, Fielding JW, Douglas G, Ratnayaka I, Robbins PA, Pugh CW, Buckler KJ, Ratcliffe PJ, Bishop T. Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF-2 pathway. The Journal of Physiology. PMID 26337139 DOI: 10.1113/Jp271050  0.43
2015 Livermore S, Pan J, Yeger H, Ratcliffe P, Bishop T, Cutz E. Augmented 5-HT Secretion in Pulmonary Neuroepithelial Bodies from PHD1 Null Mice. Advances in Experimental Medicine and Biology. 860: 309-13. PMID 26303495 DOI: 10.1007/978-3-319-18440-1_35  0.379
2015 Simpson PD, Eipper BA, Katz MJ, Gándara L, Wappner P, Fischer R, Hodson EJ, Ratcliffe PJ, Masson N. Striking Oxygen Sensitivity of the Peptidylglycine alpha-Amidating Monooxygenase (PAM) in Neuroendocrine Cells. The Journal of Biological Chemistry. PMID 26296884 DOI: 10.1074/Jbc.M115.667246  0.41
2015 Salama R, Masson N, Simpson P, Sciesielski LK, Sun M, Tian YM, Ratcliffe PJ, Mole DR. Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer. Plos One. 10: e0134645. PMID 26262842 DOI: 10.1371/Journal.Pone.0134645  0.386
2015 Chan MC, Atasoylu O, Hodson E, Tumber A, Leung IK, Chowdhury R, Gómez-Pérez V, Demetriades M, Rydzik AM, Holt-Martyn J, Tian YM, Bishop T, Claridge TD, Kawamura A, Pugh CW, ... Ratcliffe PJ, et al. Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain. Plos One. 10: e0132004. PMID 26147748 DOI: 10.1371/Journal.Pone.0132004  0.405
2015 Bishop T, Ratcliffe PJ. HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine Circulation Research. 117: 65-79. PMID 26089364 DOI: 10.1161/Circresaha.117.305109  0.438
2015 Michailidou Z, Morton NM, Moreno Navarrete JM, West CC, Stewart KJ, Fernández-Real JM, Schofield CJ, Seckl JR, Ratcliffe PJ. Adipocyte pseudohypoxia suppresses lipolysis and facilitates benign adipose tissue expansion. Diabetes. 64: 733-45. PMID 25377876 DOI: 10.2337/Db14-0233  0.363
2015 Choudhry H, Schodel J, Albukhari A, Haider S, Buffa F, Ratcliffe PJ, Mole DR, Ragousis I, Harris AL. Abstract P2-05-01: The non-coding transcriptome of hypoxic breast cancer: Novel insights of clinical relevant long non-coding RNA in hypoxia signalling Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-P2-05-01  0.339
2014 Bishop T, Ratcliffe PJ. Signaling hypoxia by hypoxia-inducible factor protein hydroxylases: a historical overview and future perspectives. Hypoxia (Auckland, N.Z.). 2: 197-213. PMID 27774477 DOI: 10.2147/Hp.S47598  0.457
2014 Choudhry H, Albukhari A, Morotti M, Hider S, Moralli D, Smythies J, Schödel J, Green CM, Camps C, Buffa F, Ratcliffe P, Ragoussis J, Harris AL, Mole DR. Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival. Oncogene. PMID 25417700 DOI: 10.1038/Onc.2014.378  0.412
2014 Couvé S, Ladroue C, Laine E, Mahtouk K, Guégan J, Gad S, Le Jeune H, Le Gentil M, Nuel G, Kim WY, Lecomte B, Pagès JC, Collin C, Lasne F, Benusiglio PR, ... ... Ratcliffe P, et al. Genetic evidence of a precisely tuned dysregulation in the hypoxia signaling pathway during oncogenesis. Cancer Research. 74: 6554-64. PMID 25371412 DOI: 10.1158/0008-5472.Can-14-1161  0.31
2014 Katz MJ, Acevedo JM, Loenarz C, Galagovsky D, Liu-Yi P, Pérez-Pepe M, Thalhammer A, Sekirnik R, Ge W, Melani M, Thomas MG, Simonetta S, Boccaccio GL, Schofield CJ, Cockman ME, ... Ratcliffe PJ, et al. Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth. Proceedings of the National Academy of Sciences of the United States of America. 111: 4025-30. PMID 24550463 DOI: 10.1073/Pnas.1314485111  0.347
2014 Loenarz C, Sekirnik R, Thalhammer A, Ge W, Spivakovsky E, Mackeen MM, McDonough MA, Cockman ME, Kessler BM, Ratcliffe PJ, Wolf A, Schofield CJ. Hydroxylation of the eukaryotic ribosomal decoding center affects translational accuracy. Proceedings of the National Academy of Sciences of the United States of America. 111: 4019-24. PMID 24550462 DOI: 10.1073/Pnas.1311750111  0.422
2014 Singleton RS, Liu-Yi P, Formenti F, Ge W, Sekirnik R, Fischer R, Adam J, Pollard PJ, Wolf A, Thalhammer A, Loenarz C, Flashman E, Yamamoto A, Coleman ML, Kessler BM, ... ... Ratcliffe PJ, et al. OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation. Proceedings of the National Academy of Sciences of the United States of America. 111: 4031-6. PMID 24550447 DOI: 10.1073/Pnas.1314482111  0.396
2014 Masson N, Ratcliffe PJ. Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways. Cancer & Metabolism. 2: 3. PMID 24491179 DOI: 10.1186/2049-3002-2-3  0.325
2014 Choudhry H, Schödel J, Oikonomopoulos S, Camps C, Grampp S, Harris AL, Ratcliffe PJ, Ragoussis J, Mole DR. Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2. Embo Reports. 15: 70-6. PMID 24363272 DOI: 10.1002/Embr.201337642  0.343
2014 Petousi N, Croft QP, Cavalleri GL, Cheng HY, Formenti F, Ishida K, Lunn D, McCormack M, Shianna KV, Talbot NP, Ratcliffe PJ, Robbins PA. Tibetans living at sea level have a hyporesponsive hypoxia-inducible factor system and blunted physiological responses to hypoxia. Journal of Applied Physiology (Bethesda, Md. : 1985). 116: 893-904. PMID 24030663 DOI: 10.1152/Japplphysiol.00535.2013  0.421
2014 Ratcliffe PJ. Oncogenic switching of hypoxia signalling pathways Cancer & Metabolism. 2. DOI: 10.1186/2049-3002-2-S1-O8  0.401
2013 Hopkinson RJ, Tumber A, Yapp C, Chowdhury R, Aik W, Che KH, Li XS, Kristensen JB, King ON, Chan MC, Yeoh KK, Choi H, Walport LJ, Thinnes CC, Bush JT, ... ... Ratcliffe PJ, et al. 5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation. Chemical Science (Royal Society of Chemistry : 2010). 4: 3110-3117. PMID 26682036 DOI: 10.1039/C3Sc51122G  0.308
2013 Guitart AV, Subramani C, Armesilla-Diaz A, Smith G, Sepulveda C, Gezer D, Vukovic M, Dunn K, Pollard P, Holyoake TL, Enver T, Ratcliffe PJ, Kranc KR. Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance. Blood. 122: 1741-5. PMID 23894152 DOI: 10.1182/Blood-2013-02-484923  0.35
2013 Bishop T, Talbot NP, Turner PJ, Nicholls LG, Pascual A, Hodson EJ, Douglas G, Fielding JW, Smith TG, Demetriades M, Schofield CJ, Robbins PA, Pugh CW, Buckler KJ, Ratcliffe PJ. Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2. The Journal of Physiology. 591: 3565-77. PMID 23690557 DOI: 10.1113/Jphysiol.2012.247254  0.396
2013 Chowdhury R, Candela-Lena JI, Chan MC, Greenald DJ, Yeoh KK, Tian YM, McDonough MA, Tumber A, Rose NR, Conejo-Garcia A, Demetriades M, Mathavan S, Kawamura A, Lee MK, van Eeden F, ... ... Ratcliffe PJ, et al. Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. Acs Chemical Biology. 8: 1488-96. PMID 23683440 DOI: 10.1021/Cb400088Q  0.43
2013 Ratcliffe PJ. Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer. The Journal of Physiology. 591: 2027-42. PMID 23401619 DOI: 10.1113/Jphysiol.2013.251470  0.457
2013 Schödel J, Mole DR, Ratcliffe PJ. Pan-genomic binding of hypoxia-inducible transcription factors. Biological Chemistry. 394: 507-17. PMID 23324384 DOI: 10.1515/Hsz-2012-0351  0.398
2013 Yeoh KK, Chan MC, Thalhammer A, Demetriades M, Chowdhury R, Tian YM, Stolze I, McNeill LA, Lee MK, Woon EC, Mackeen MM, Kawamura A, Ratcliffe PJ, Mecinović J, Schofield CJ. Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion. Organic & Biomolecular Chemistry. 11: 732-45. PMID 23151668 DOI: 10.1039/C2Ob26648B  0.309
2013 Guitart AV, Vukovic M, Subramani C, Dunn K, Pollard P, Ratcliffe PJ, Holyoake TL, Kranc K. HIF-1α Is Not Essential For The Establishment Of MLL-Leukaemic Stem Cells Blood. 122: 3767-3767. DOI: 10.1182/Blood.V122.21.3767.3767  0.336
2012 Ge W, Wolf A, Feng T, Ho CH, Sekirnik R, Zayer A, Granatino N, Cockman ME, Loenarz C, Loik ND, Hardy AP, Claridge TD, Hamed RB, Chowdhury R, Gong L, ... ... Ratcliffe PJ, et al. Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. Nature Chemical Biology. 8: 960-2. PMID 23103944 DOI: 10.1038/Nchembio.1093  0.332
2012 Pan J, Yeger H, Ratcliffe P, Bishop T, Cutz E. Hyperplasia of pulmonary neuroepithelial bodies (NEB) in lungs of prolyl hydroxylase -1(PHD-1) deficient mice. Advances in Experimental Medicine and Biology. 758: 149-55. PMID 23080156 DOI: 10.1007/978-94-007-4584-1_21  0.302
2012 Chen RL, Nagel S, Papadakis M, Bishop T, Pollard P, Ratcliffe PJ, Pugh CW, Buchan AM. Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: Insights from genetically modified mice Journal of Physiology. 590: 4079-4091. PMID 22615432 DOI: 10.1113/Jphysiol.2012.232884  0.3
2012 Schödel J, Bardella C, Sciesielski LK, Brown JM, Pugh CW, Buckle V, Tomlinson IP, Ratcliffe PJ, Mole DR. Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression. Nature Genetics. 44: 420-5, S1-2. PMID 22406644 DOI: 10.1038/Ng.2204  0.356
2012 Masson N, Singleton RS, Sekirnik R, Trudgian DC, Ambrose LJ, Miranda MX, Tian YM, Kessler BM, Schofield CJ, Ratcliffe PJ. The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity. Embo Reports. 13: 251-7. PMID 22310300 DOI: 10.1038/Embor.2012.9  0.383
2012 Foxler DE, Bridge KS, James V, Webb TM, Mee M, Wong SC, Feng Y, Constantin-Teodosiu D, Petursdottir TE, Bjornsson J, Ingvarsson S, Ratcliffe PJ, Longmore GD, Sharp TV. The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. Nature Cell Biology. 14: 201-8. PMID 22286099 DOI: 10.1038/Ncb2424  0.408
2012 Michailidou Z, Turban S, Miller E, Zou X, Schrader J, Ratcliffe PJ, Hadoke PW, Walker BR, Iredale JP, Morton NM, Seckl JR. Increased angiogenesis protects against adipose hypoxia and fibrosis in metabolic disease-resistant 11β-hydroxysteroid dehydrogenase type 1 (HSD1)-deficient mice. The Journal of Biological Chemistry. 287: 4188-97. PMID 22158867 DOI: 10.1074/Jbc.M111.259325  0.303
2011 Adam J, Ratcliffe PJ, Pollard PJ. Novel insights into FH-associated disease are KEAPing the lid on oncogenic HIF signalling. Oncotarget. 2: 820-1. PMID 22064867 DOI: 10.18632/Oncotarget.348  0.43
2011 Adam J, Hatipoglu E, O'Flaherty L, Ternette N, Sahgal N, Lockstone H, Baban D, Nye E, Stamp GW, Wolhuter K, Stevens M, Fischer R, Carmeliet P, Maxwell PH, Pugh CW, ... ... Ratcliffe PJ, et al. Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling. Cancer Cell. 20: 524-37. PMID 22014577 DOI: 10.1016/J.Ccr.2011.09.006  0.395
2011 Singleton RS, Trudgian DC, Fischer R, Kessler BM, Ratcliffe PJ, Cockman ME. Quantitative mass spectrometry reveals dynamics of factor-inhibiting hypoxia-inducible factor-catalyzed hydroxylation. The Journal of Biological Chemistry. 286: 33784-94. PMID 21808058 DOI: 10.1074/Jbc.M111.262808  0.446
2011 Bardella C, El-Bahrawy M, Frizzell N, Adam J, Ternette N, Hatipoglu E, Howarth K, O'Flaherty L, Roberts I, Turner G, Taylor J, Giaslakiotis K, Macaulay VM, Harris AL, Chandra A, ... ... Ratcliffe PJ, et al. Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status. The Journal of Pathology. 225: 4-11. PMID 21630274 DOI: 10.1002/Path.2932  0.302
2011 Chowdhury R, Yeoh KK, Tian YM, Hillringhaus L, Bagg EA, Rose NR, Leung IK, Li XS, Woon EC, Yang M, McDonough MA, King ON, Clifton IJ, Klose RJ, Claridge TD, ... Ratcliffe PJ, et al. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. Embo Reports. 12: 463-9. PMID 21460794 DOI: 10.1038/Embor.2011.43  0.302
2011 Schödel J, Oikonomopoulos S, Ragoussis J, Pugh CW, Ratcliffe PJ, Mole DR. High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq. Blood. 117: e207-17. PMID 21447827 DOI: 10.1182/Blood-2010-10-314427  0.41
2011 Formenti F, Beer PA, Croft QP, Dorrington KL, Gale DP, Lappin TR, Lucas GS, Maher ER, Maxwell PH, McMullin MF, O'Connor DF, Percy MJ, Pugh CW, Ratcliffe PJ, Smith TG, et al. Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2alpha gain-of-function mutation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 2001-11. PMID 21389259 DOI: 10.1096/Fj.10-177378  0.378
2011 Tian YM, Yeoh KK, Lee MK, Eriksson T, Kessler BM, Kramer HB, Edelmann MJ, Willam C, Pugh CW, Schofield CJ, Ratcliffe PJ. Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors. The Journal of Biological Chemistry. 286: 13041-51. PMID 21335549 DOI: 10.1074/Jbc.M110.211110  0.437
2011 Walmsley SR, Chilvers ER, Thompson AA, Vaughan K, Marriott HM, Parker LC, Shaw G, Parmar S, Schneider M, Sabroe I, Dockrell DH, Milo M, Taylor CT, Johnson RS, Pugh CW, ... Ratcliffe PJ, et al. Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice. The Journal of Clinical Investigation. 121: 1053-63. PMID 21317538 DOI: 10.1172/Jci43273  0.408
2011 Thalhammer A, Bencokova Z, Poole R, Loenarz C, Adam J, O'Flaherty L, Schödel J, Mole D, Giaslakiotis K, Schofield CJ, Hammond EM, Ratcliffe PJ, Pollard PJ. Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α). Plos One. 6: e16210. PMID 21264265 DOI: 10.1371/Journal.Pone.0016210  0.433
2011 Yang M, Chowdhury R, Ge W, Hamed RB, McDonough MA, Claridge TD, Kessler BM, Cockman ME, Ratcliffe PJ, Schofield CJ. Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains. The Febs Journal. 278: 1086-97. PMID 21251231 DOI: 10.1111/J.1742-4658.2011.08022.X  0.373
2011 Yang M, Ge W, Chowdhury R, Claridge TD, Kramer HB, Schmierer B, McDonough MA, Gong L, Kessler BM, Ratcliffe PJ, Coleman ML, Schofield CJ. Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor. The Journal of Biological Chemistry. 286: 7648-60. PMID 21177872 DOI: 10.1074/Jbc.M110.193540  0.376
2011 Loenarz C, Coleman ML, Boleininger A, Schierwater B, Holland PW, Ratcliffe PJ, Schofield CJ. The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens. Embo Reports. 12: 63-70. PMID 21109780 DOI: 10.1038/Embor.2010.170  0.447
2011 Jiang B, Ren C, Li Y, Lu Y, Li W, Wu Y, Gao Y, Ratcliffe PJ, Liu H, Zhang C. Sodium sulfite is a potential hypoxia inducer that mimics hypoxic stress in Caenorhabditis elegans. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 16: 267-74. PMID 21057967 DOI: 10.1007/S00775-010-0723-1  0.373
2011 Lakhal S, Schödel J, Townsend AR, Pugh CW, Ratcliffe PJ, Mole DR. Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis. The Journal of Biological Chemistry. 286: 4090-7. PMID 20966077 DOI: 10.1074/Jbc.M110.173096  0.4
2011 Astuti D, Ricketts CJ, Chowdhury R, McDonough MA, Gentle D, Kirby G, Schlisio S, Kenchappa RS, Carter BD, Kaelin WG, Ratcliffe PJ, Schofield CJ, Latif F, Maher ER. Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility. Endocrine-Related Cancer. 18: 73-83. PMID 20959442 DOI: 10.1677/Erc-10-0113  0.362
2011 Perez-Perri JI, Cockman M, Dekanty A, Ratcliffe PJ, Wappner P. Pontin and reptin: Two novel regulators of the transcriptional response to hypoxia Developmental Biology. 356: 257. DOI: 10.1016/J.Ydbio.2011.05.487  0.38
2011 Ratcliffe PJ, Eckardt K, Bauer C. Hypoxia, Erythropoietin Gene Expression, and Erythropoiesis Comprehensive Physiology. 1125-1153. DOI: 10.1002/Cphy.Cp040249  0.407
2010 O'Flaherty L, Adam J, Heather LC, Zhdanov AV, Chung YL, Miranda MX, Croft J, Olpin S, Clarke K, Pugh CW, Griffiths J, Papkovsky D, Ashrafian H, Ratcliffe PJ, Pollard PJ. Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism. Human Molecular Genetics. 19: 3844-51. PMID 20660115 DOI: 10.1093/Hmg/Ddq305  0.38
2010 Formenti F, Constantin-Teodosiu D, Emmanuel Y, Cheeseman J, Dorrington KL, Edwards LM, Humphreys SM, Lappin TR, McMullin MF, McNamara CJ, Mills W, Murphy JA, O'Connor DF, Percy MJ, Ratcliffe PJ, et al. Regulation of human metabolism by hypoxia-inducible factor. Proceedings of the National Academy of Sciences of the United States of America. 107: 12722-7. PMID 20616028 DOI: 10.1073/Pnas.1002339107  0.332
2010 Loenarz C, Ge W, Coleman ML, Rose NR, Cooper CD, Klose RJ, Ratcliffe PJ, Schofield CJ. PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase. Human Molecular Genetics. 19: 217-22. PMID 19843542 DOI: 10.1093/Hmg/Ddp480  0.309
2009 Cockman ME, Webb JD, Ratcliffe PJ. FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins. Annals of the New York Academy of Sciences. 1177: 9-18. PMID 19845602 DOI: 10.1111/J.1749-6632.2009.05042.X  0.412
2009 Smith TG, Talbot NP, Privat C, Rivera-Ch M, Nickol AH, Ratcliffe PJ, Dorrington KL, León-Velarde F, Robbins PA. Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: two randomized controlled trials. Jama. 302: 1444-50. PMID 19809026 DOI: 10.1001/Jama.2009.1404  0.317
2009 Coleman ML, Ratcliffe PJ. Signalling cross talk of the HIF system: involvement of the FIH protein. Current Pharmaceutical Design. 15: 3904-7. PMID 19671041 DOI: 10.2174/138161209789649448  0.337
2009 Coleman ML, Ratcliffe PJ. Angiogenesis: escape from hypoxia. Nature Medicine. 15: 491-3. PMID 19424207 DOI: 10.1038/Nm0509-491  0.331
2009 Mole DR, Blancher C, Copley RR, Pollard PJ, Gleadle JM, Ragoussis J, Ratcliffe PJ. Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts. The Journal of Biological Chemistry. 284: 16767-75. PMID 19386601 DOI: 10.1074/Jbc.M901790200  0.386
2009 Ebbesen P, Pettersen EO, Gorr TA, Jobst G, Williams K, Kieninger J, Wenger RH, Pastorekova S, Dubois L, Lambin P, Wouters BG, Van Den Beucken T, Supuran CT, Poellinger L, Ratcliffe P, et al. Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies. Journal of Enzyme Inhibition and Medicinal Chemistry. 24: 1-39. PMID 19330638 DOI: 10.1080/14756360902784425  0.361
2009 Webb JD, Murányi A, Pugh CW, Ratcliffe PJ, Coleman ML. MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH). The Biochemical Journal. 420: 327-33. PMID 19245366 DOI: 10.1042/Bj20081905  0.411
2009 Mazzone M, Dettori D, Leite de Oliveira R, Loges S, Schmidt T, Jonckx B, Tian YM, Lanahan AA, Pollard P, Ruiz de Almodovar C, De Smet F, Vinckier S, Aragonés J, Debackere K, Luttun A, ... ... Ratcliffe P, et al. Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell. 136: 839-51. PMID 19217150 DOI: 10.1016/J.Cell.2009.01.020  0.362
2009 Kelly L, McDonough MA, Coleman ML, Ratcliffe PJ, Schofield CJ. Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold. Molecular Biosystems. 5: 52-8. PMID 19081931 DOI: 10.1039/B815271C  0.301
2009 Lakhal S, Talbot NP, Crosby A, Stoepker C, Townsend AR, Robbins PA, Pugh CW, Ratcliffe PJ, Mole DR. Regulation of growth differentiation factor 15 expression by intracellular iron. Blood. 113: 1555-63. PMID 19047680 DOI: 10.1182/Blood-2008-07-170431  0.34
2009 Cockman ME, Webb JD, Kramer HB, Kessler BM, Ratcliffe PJ. Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins. Molecular & Cellular Proteomics : McP. 8: 535-46. PMID 18936059 DOI: 10.1074/Mcp.M800340-Mcp200  0.37
2008 Lienard BM, Conejo-García A, Stolze I, Loenarz C, Oldham NJ, Ratcliffe PJ, Schofield CJ. Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases. Chemical Communications (Cambridge, England). 6393-5. PMID 19048166 DOI: 10.1039/B814440K  0.423
2008 Smith TG, Balanos GM, Croft QP, Talbot NP, Dorrington KL, Ratcliffe PJ, Robbins PA. The increase in pulmonary arterial pressure caused by hypoxia depends on iron status. The Journal of Physiology. 586: 5999-6005. PMID 18955380 DOI: 10.1113/Jphysiol.2008.160960  0.309
2008 Pollard PJ, Loenarz C, Mole DR, McDonough MA, Gleadle JM, Schofield CJ, Ratcliffe PJ. Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha. The Biochemical Journal. 416: 387-94. PMID 18713068 DOI: 10.1042/Bj20081238  0.448
2008 Kaelin WG, Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Molecular Cell. 30: 393-402. PMID 18498744 DOI: 10.1016/J.Molcel.2008.04.009  0.422
2008 Smith TG, Robbins PA, Ratcliffe PJ. The human side of hypoxia-inducible factor. British Journal of Haematology. 141: 325-34. PMID 18410568 DOI: 10.1111/J.1365-2141.2008.07029.X  0.452
2008 Bishop T, Gallagher D, Pascual A, Lygate CA, de Bono JP, Nicholls LG, Ortega-Saenz P, Oster H, Wijeyekoon B, Sutherland AI, Grosfeld A, Aragones J, Schneider M, van Geyte K, Teixeira D, ... ... Ratcliffe PJ, et al. Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice. Molecular and Cellular Biology. 28: 3386-400. PMID 18332118 DOI: 10.1128/Mcb.02041-07  0.371
2008 Aragonés J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, Harten SK, ... ... Ratcliffe P, et al. Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nature Genetics. 40: 170-80. PMID 18176562 DOI: 10.1038/Ng.2007.62  0.401
2008 Mole DR, Ratcliffe PJ. Cellular oxygen sensing in health and disease. Pediatric Nephrology (Berlin, Germany). 23: 681-94. PMID 17955264 DOI: 10.1007/S00467-007-0632-X  0.434
2007 Hewitson KS, Schofield CJ, Ratcliffe PJ. Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2. Methods in Enzymology. 435: 25-42. PMID 17998047 DOI: 10.1016/S0076-6879(07)35002-7  0.431
2007 Coleman ML, Ratcliffe PJ. Oxygen sensing and hypoxia-induced responses. Essays in Biochemistry. 43: 1-15. PMID 17705789 DOI: 10.1042/Bse0430001  0.452
2007 Coleman ML, McDonough MA, Hewitson KS, Coles C, Mecinovic J, Edelmann M, Cook KM, Cockman ME, Lancaster DE, Kessler BM, Oldham NJ, Ratcliffe PJ, Schofield CJ. Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. The Journal of Biological Chemistry. 282: 24027-38. PMID 17573339 DOI: 10.1074/Jbc.M704102200  0.405
2007 Ratcliffe PJ. Fumarate hydratase deficiency and cancer: activation of hypoxia signaling? Cancer Cell. 11: 303-5. PMID 17418405 DOI: 10.1016/J.Ccr.2007.03.015  0.386
2007 Ratcliffe PJ. HIF-1 and HIF-2: working alone or together in hypoxia? The Journal of Clinical Investigation. 117: 862-5. PMID 17404612 DOI: 10.1172/Jci31750  0.437
2007 Grosfeld A, Stolze IP, Cockman ME, Pugh CW, Edelmann M, Kessler B, Bullock AN, Ratcliffe PJ, Masson N. Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor. The Journal of Biological Chemistry. 282: 13264-9. PMID 17339318 DOI: 10.1074/Jbc.M611648200  0.342
2007 Ehrismann D, Flashman E, Genn DN, Mathioudakis N, Hewitson KS, Ratcliffe PJ, Schofield CJ. Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay. The Biochemical Journal. 401: 227-34. PMID 16952279 DOI: 10.1042/Bj20061151  0.418
2006 Ratcliffe PJ. Understanding hypoxia signalling in cells--a new therapeutic opportunity? Clinical Medicine (London, England). 6: 573-8. PMID 17228556 DOI: 10.7861/Clinmedicine.6-6-573  0.461
2006 Cockman ME, Lancaster DE, Stolze IP, Hewitson KS, McDonough MA, Coleman ML, Coles CH, Yu X, Hay RT, Ley SC, Pugh CW, Oldham NJ, Masson N, Schofield CJ, Ratcliffe PJ. Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proceedings of the National Academy of Sciences of the United States of America. 103: 14767-72. PMID 17003112 DOI: 10.1073/Pnas.0606877103  0.416
2006 Smith TG, Brooks JT, Balanos GM, Lappin TR, Layton DM, Leedham DL, Liu C, Maxwell PH, McMullin MF, McNamara CJ, Percy MJ, Pugh CW, Ratcliffe PJ, Talbot NP, Treacy M, et al. Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology. Plos Medicine. 3: e290. PMID 16768548 DOI: 10.1371/Journal.Pmed.0030290  0.382
2006 Willam C, Maxwell PH, Nichols L, Lygate C, Tian YM, Bernhardt W, Wiesener M, Ratcliffe PJ, Eckardt KU, Pugh CW. HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation. Journal of Molecular and Cellular Cardiology. 41: 68-77. PMID 16765982 DOI: 10.1016/J.Yjmcc.2006.04.009  0.357
2006 Stolze IP, Mole DR, Ratcliffe PJ. Regulation of HIF: prolyl hydroxylases. Novartis Foundation Symposium. 272: 15-25; discussion 25. PMID 16686427 DOI: 10.1002/9780470035009.Ch3  0.457
2006 Elvidge GP, Glenny L, Appelhoff RJ, Ratcliffe PJ, Ragoussis J, Gleadle JM. Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways. The Journal of Biological Chemistry. 281: 15215-26. PMID 16565084 DOI: 10.1074/Jbc.M511408200  0.453
2006 Knowles HJ, Mole DR, Ratcliffe PJ, Harris AL. Normoxic stabilization of hypoxia-inducible factor-1alpha by modulation of the labile iron pool in differentiating U937 macrophages: effect of natural resistance-associated macrophage protein 1. Cancer Research. 66: 2600-7. PMID 16510578 DOI: 10.1158/0008-5472.Can-05-2351  0.405
2006 Tian YM, Mole DR, Ratcliffe PJ, Gleadle JM. Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation. The Biochemical Journal. 397: 179-86. PMID 16509823 DOI: 10.1042/Bj20051996  0.477
2005 Centanin L, Ratcliffe PJ, Wappner P. Reversion of lethality and growth defects in Fatiga oxygen-sensor mutant flies by loss of hypoxia-inducible factor-alpha/Sima. Embo Reports. 6: 1070-5. PMID 16179946 DOI: 10.1038/Sj.Embor.7400528  0.412
2005 Schofield CJ, Ratcliffe PJ. Signalling hypoxia by HIF hydroxylases. Biochemical and Biophysical Research Communications. 338: 617-26. PMID 16139242 DOI: 10.1016/J.Bbrc.2005.08.111  0.431
2005 Isaacs JS, Jung YJ, Mole DR, Lee S, Torres-Cabala C, Chung YL, Merino M, Trepel J, Zbar B, Toro J, Ratcliffe PJ, Linehan WM, Neckers L. HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. Cancer Cell. 8: 143-53. PMID 16098467 DOI: 10.1016/J.Ccr.2005.06.017  0.409
2005 Raval RR, Lau KW, Tran MG, Sowter HM, Mandriota SJ, Li JL, Pugh CW, Maxwell PH, Harris AL, Ratcliffe PJ. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Molecular and Cellular Biology. 25: 5675-86. PMID 15964822 DOI: 10.1128/Mcb.25.13.5675-5686.2005  0.373
2005 Willam C, Nicholls LG, Ratcliffe PJ, Pugh CW, Maxwell PH. The prolyl hydroxylase enzymes that act as oxygen sensors regulating destruction of hypoxia-inducible factor alpha. Advances in Enzyme Regulation. 44: 75-92. PMID 15581484 DOI: 10.1016/J.Advenzreg.2003.11.017  0.396
2004 Tuckerman JR, Zhao Y, Hewitson KS, Tian YM, Pugh CW, Ratcliffe PJ, Mole DR. Determination and comparison of specific activity of the HIF-prolyl hydroxylases. Febs Letters. 576: 145-50. PMID 15474027 DOI: 10.1016/J.Febslet.2004.09.005  0.439
2004 Bishop T, Lau KW, Epstein AC, Kim SK, Jiang M, O'Rourke D, Pugh CW, Gleadle JM, Taylor MS, Hodgkin J, Ratcliffe PJ. Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans. Plos Biology. 2: e289. PMID 15361934 DOI: 10.1371/Journal.Pbio.0020289  0.421
2004 Stolze IP, Tian YM, Appelhoff RJ, Turley H, Wykoff CC, Gleadle JM, Ratcliffe PJ. Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected]. The Journal of Biological Chemistry. 279: 42719-25. PMID 15302861 DOI: 10.1074/Jbc.M406713200  0.496
2004 Masson N, Appelhoff RJ, Tuckerman JR, Tian YM, Demol H, Puype M, Vandekerckhove J, Ratcliffe PJ, Pugh CW. The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin. Febs Letters. 570: 166-70. PMID 15251459 DOI: 10.1016/J.Febslet.2004.06.040  0.436
2004 Appelhoff RJ, Tian YM, Raval RR, Turley H, Harris AL, Pugh CW, Ratcliffe PJ, Gleadle JM. Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. The Journal of Biological Chemistry. 279: 38458-65. PMID 15247232 DOI: 10.1074/Jbc.M406026200  0.44
2004 Lancaster DE, McNeill LA, McDonough MA, Aplin RT, Hewitson KS, Pugh CW, Ratcliffe PJ, Schofield CJ. Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity. The Biochemical Journal. 383: 429-37. PMID 15239670 DOI: 10.1042/Bj20040735  0.42
2004 Metzen E, Ratcliffe PJ. HIF hydroxylation and cellular oxygen sensing. Biological Chemistry. 385: 223-30. PMID 15134335 DOI: 10.1515/Bc.2004.016  0.482
2004 Schofield CJ, Ratcliffe PJ. Oxygen sensing by HIF hydroxylases. Nature Reviews. Molecular Cell Biology. 5: 343-54. PMID 15122348 DOI: 10.1038/Nrm1366  0.436
2004 Kageyama Y, Koshiji M, To KK, Tian YM, Ratcliffe PJ, Huang LE. Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1028-30. PMID 15084514 DOI: 10.1096/Fj.03-1233Fje  0.399
2004 Masson N, Ratcliffe PJ. Analysis of von Hippel-Lindau tumor suppressor as a mediator of cellular oxygen sensing. Methods in Enzymology. 381: 305-20. PMID 15063683 DOI: 10.1016/S0076-6879(04)81021-8  0.329
2004 Wykoff CC, Sotiriou C, Cockman ME, Ratcliffe PJ, Maxwell P, Liu E, Harris AL. Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene. British Journal of Cancer. 90: 1235-43. PMID 15026807 DOI: 10.1038/Sj.Bjc.6601657  0.422
2004 Masson N, Ratcliffe PJ. HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels. Journal of Cell Science. 116: 3041-9. PMID 12829734 DOI: 10.1242/Jcs.00655  0.46
2003 Sowter HM, Raval RR, Moore JW, Ratcliffe PJ, Harris AL. Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia. Cancer Research. 63: 6130-4. PMID 14559790  0.315
2003 Mole DR, Schlemminger I, McNeill LA, Hewitson KS, Pugh CW, Ratcliffe PJ, Schofield CJ. 2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase. Bioorganic & Medicinal Chemistry Letters. 13: 2677-80. PMID 12873492 DOI: 10.1016/S0960-894X(03)00539-0  0.408
2003 Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system. Nature Medicine. 9: 677-84. PMID 12778166 DOI: 10.1038/Nm0603-677  0.442
2003 Knowles HJ, Raval RR, Harris AL, Ratcliffe PJ. Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells. Cancer Research. 63: 1764-8. PMID 12702559  0.34
2003 Schlemminger I, Mole DR, McNeill LA, Dhanda A, Hewitson KS, Tian YM, Ratcliffe PJ, Pugh CW, Schofield CJ. Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases. Bioorganic & Medicinal Chemistry Letters. 13: 1451-4. PMID 12668010 DOI: 10.1016/S0960-894X(03)00149-5  0.313
2003 Pugh CW, Ratcliffe PJ. The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis. Seminars in Cancer Biology. 13: 83-9. PMID 12507560 DOI: 10.1016/S1044-579X(02)00103-7  0.462
2003 Wiesener MS, Jürgensen JS, Rosenberger C, Scholze CK, Hörstrup JH, Warnecke C, Mandriota S, Bechmann I, Frei UA, Pugh CW, Ratcliffe PJ, Bachmann S, Maxwell PH, Eckardt KU. Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 271-3. PMID 12490539 DOI: 10.1096/Fj.02-0445Fje  0.413
2003 Elkins JM, Hewitson KS, McNeill LA, Seibel JF, Schlemminger I, Pugh CW, Ratcliffe PJ, Schofield CJ. Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha. The Journal of Biological Chemistry. 278: 1802-6. PMID 12446723 DOI: 10.1074/Jbc.C200644200  0.394
2003 Ratcliffe PJ. From erythropoietin to oxygen: hypoxia-inducible factor hydroxylases and the hypoxia signal pathway. Blood Purification. 20: 445-50. PMID 12207089 DOI: 10.1159/000065201  0.479
2002 Lavista-Llanos S, Centanin L, Irisarri M, Russo DM, Gleadle JM, Bocca SN, Muzzopappa M, Ratcliffe PJ, Wappner P. Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar. Molecular and Cellular Biology. 22: 6842-53. PMID 12215541 DOI: 10.1128/Mcb.22.19.6842-6853.2002  0.461
2002 Willam C, Masson N, Tian YM, Mahmood SA, Wilson MI, Bicknell R, Eckardt KU, Maxwell PH, Ratcliffe PJ, Pugh CW. Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 99: 10423-8. PMID 12149454 DOI: 10.1073/Pnas.162119399  0.419
2002 Mandriota SJ, Turner KJ, Davies DR, Murray PG, Morgan NV, Sowter HM, Wykoff CC, Maher ER, Harris AL, Ratcliffe PJ, Maxwell PH. HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron. Cancer Cell. 1: 459-68. PMID 12124175 DOI: 10.1016/S1535-6108(02)00071-5  0.365
2002 Mole DR, Pugh CW, Ratcliffe PJ, Maxwell PH. Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex. Advances in Enzyme Regulation. 42: 333-47. PMID 12123724 DOI: 10.1016/S0065-2571(01)00037-1  0.383
2002 Rosenberger C, Mandriota S, Jürgensen JS, Wiesener MS, Hörstrup JH, Frei U, Ratcliffe PJ, Maxwell PH, Bachmann S, Eckardt KU. Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys. Journal of the American Society of Nephrology : Jasn. 13: 1721-32. PMID 12089367 DOI: 10.1097/01.Asn.0000017223.49823.2A  0.421
2002 Hon WC, Wilson MI, Harlos K, Claridge TD, Schofield CJ, Pugh CW, Maxwell PH, Ratcliffe PJ, Stuart DI, Jones EY. Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. Nature. 417: 975-8. PMID 12050673 DOI: 10.1038/Nature00767  0.405
2002 Hewitson KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, Welford RW, Elkins JM, Oldham NJ, Bhattacharya S, Gleadle JM, Ratcliffe PJ, Pugh CW, Schofield CJ. Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. The Journal of Biological Chemistry. 277: 26351-5. PMID 12042299 DOI: 10.1074/Jbc.C200273200  0.433
2002 McNeill LA, Hewitson KS, Gleadle JM, Horsfall LE, Oldham NJ, Maxwell PH, Pugh CW, Ratcliffe PJ, Schofield CJ. The use of dioxygen by HIF prolyl hydroxylase (PHD1). Bioorganic & Medicinal Chemistry Letters. 12: 1547-50. PMID 12039559 DOI: 10.1016/S0960-894X(02)00219-6  0.374
2002 Turner KJ, Moore JW, Jones A, Taylor CF, Cuthbert-Heavens D, Han C, Leek RD, Gatter KC, Maxwell PH, Ratcliffe PJ, Cranston D, Harris AL. Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation. Cancer Research. 62: 2957-61. PMID 12019178  0.303
2002 Maxwell PH, Ratcliffe PJ. Oxygen sensors and angiogenesis. Seminars in Cell & Developmental Biology. 13: 29-37. PMID 11969369 DOI: 10.1006/Scdb.2001.0287  0.458
2002 Turner KJ, Crew JP, Wykoff CC, Watson PH, Poulsom R, Pastorek J, Ratcliffe PJ, Cranston D, Harris AL. The hypoxia-inducible genes VEGF and CA9 are differentially regulated in superficial vs invasive bladder cancer. British Journal of Cancer. 86: 1276-82. PMID 11953885 DOI: 10.1038/Sj.Bjc.6600215  0.301
2002 Maxwell PH, Pugh CW, Ratcliffe PJ. The pVHL-hIF-1 system. A key mediator of oxygen homeostasis. Advances in Experimental Medicine and Biology. 502: 365-76. PMID 11950150  0.376
2002 Mole DR, Maxwell PH, Pugh CW, Ratcliffe PJ. Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing. Iubmb Life. 52: 43-7. PMID 11795592 DOI: 10.1080/15216540252774757  0.426
2002 Pugh C, Maxwell P, Ratcliffe P. Oxygen mediated gene regulation Nephrology. 7: S21-S25. DOI: 10.1046/J.1440-1797.7.S.14.X  0.477
2001 Wykoff CC, Pugh CW, Harris AL, Maxwell PH, Ratcliffe PJ. The HIF pathway: implications for patterns of gene expression in cancer. Novartis Foundation Symposium. 240: 212-25; discussion 2. PMID 11727931 DOI: 10.1002/0470868716.Ch15  0.481
2001 Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, ... ... Ratcliffe PJ, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell. 107: 43-54. PMID 11595184 DOI: 10.1016/S0092-8674(01)00507-4  0.442
2001 Masson N, Willam C, Maxwell PH, Pugh CW, Ratcliffe PJ. Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation. The Embo Journal. 20: 5197-206. PMID 11566883 DOI: 10.1093/Emboj/20.18.5197  0.426
2001 Vaux EC, Wood SM, Cockman ME, Nicholls LG, Yeates KM, Pugh CW, Maxwell PH, Ratcliffe PJ. Selection of mutant CHO cells with constitutive activation of the HIF system and inactivation of the von Hippel-Lindau tumor suppressor. The Journal of Biological Chemistry. 276: 44323-30. PMID 11555645 DOI: 10.1074/Jbc.M104678200  0.437
2001 Clifford SC, Astuti D, Hooper L, Maxwell PH, Ratcliffe PJ, Maher ER. The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma. Oncogene. 20: 5067-74. PMID 11526493 DOI: 10.1038/Sj.Onc.1204602  0.386
2001 Vaux EC, Metzen E, Yeates KM, Ratcliffe PJ. Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain. Blood. 98: 296-302. PMID 11435296 DOI: 10.1182/Blood.V98.2.296  0.443
2001 Maxwell PH, Pugh CW, Ratcliffe PJ. Insights into the role of the von Hippel-Lindau gene product. A key player in hypoxic regulation. Experimental Nephrology. 9: 235-40. PMID 11423722 DOI: 10.1159/000052617  0.461
2001 Maxwell PH, Pugh CW, Ratcliffe PJ. Activation of the HIF pathway in cancer. Current Opinion in Genetics & Development. 11: 293-9. PMID 11377966 DOI: 10.1016/S0959-437X(00)00193-3  0.437
2001 Clifford SC, Cockman ME, Smallwood AC, Mole DR, Woodward ER, Maxwell PH, Ratcliffe PJ, Maher ER. Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease. Human Molecular Genetics. 10: 1029-38. PMID 11331613 DOI: 10.1093/Hmg/10.10.1029  0.353
2001 Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, von Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science (New York, N.Y.). 292: 468-72. PMID 11292861 DOI: 10.1126/Science.1059796  0.43
2001 Ratcliffe PJ, Pugh CW, Maxwell PH. Targeting tumors through the HIF system. Nature Medicine. 6: 1315-6. PMID 11100107 DOI: 10.1038/82113  0.392
2001 Maxwell PH, Pugh CW, Ratcliffe PJ. The pVHL-hIF-1 system. A key mediator of oxygen homeostasis. Advances in Experimental Medicine and Biology. 502: 365-376. DOI: 10.1007/978-1-4757-3401-0_24  0.49
2000 Wykoff CC, Pugh CW, Maxwell PH, Harris AL, Ratcliffe PJ. Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling. Oncogene. 19: 6297-305. PMID 11175344 DOI: 10.1038/Sj.Onc.1204012  0.43
2000 Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. The American Journal of Pathology. 157: 411-21. PMID 10934146 DOI: 10.1016/S0002-9440(10)64554-3  0.371
2000 Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Clifford SC, Maher ER, Pugh CW, Ratcliffe PJ, Maxwell PH. Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. The Journal of Biological Chemistry. 275: 25733-41. PMID 10823831 DOI: 10.1074/Jbc.M002740200  0.408
2000 Griffiths L, Binley K, Iqball S, Kan O, Maxwell P, Ratcliffe P, Lewis C, Harris A, Kingsman S, Naylor S. The macrophage - a novel system to deliver gene therapy to pathological hypoxia. Gene Therapy. 7: 255-262. PMID 10694803 DOI: 10.1038/Sj.Gt.3301058  0.353
1999 Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature. 399: 271-5. PMID 10353251 DOI: 10.1038/20459  0.466
1999 O'Rourke JF, Tian YM, Ratcliffe PJ, Pugh CW. Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha. The Journal of Biological Chemistry. 274: 2060-71. PMID 9890965 DOI: 10.1074/Jbc.274.4.2060  0.377
1998 Wiesener MS, Turley H, Allen WE, Willam C, Eckardt KU, Talks KL, Wood SM, Gatter KC, Harris AL, Pugh CW, Ratcliffe PJ, Maxwell PH. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. Blood. 92: 2260-8. PMID 9746763  0.309
1998 Bacon NCM, Wappner P, O'Rourke JF, Bartlett SM, Shilo B, Pugh CW, Ratcliffe PJ. Regulation of the Drosophila bHLH-PAS protein Sima by hypoxia: Functional evidence for homology with mammalian HIF-1α Biochemical and Biophysical Research Communications. 249: 811-816. PMID 9731218 DOI: 10.1006/Bbrc.1998.9234  0.435
1998 Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, Koch CJ, Ratcliffe P, Moons L, Jain RK, Collen D, et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. 394: 485-90. PMID 9697772 DOI: 10.1038/28867  0.412
1998 Maxwell P, Ratcliffe P. Regulation of expression of the erythropoietin gene. Current Opinion in Hematology. 5: 166-70. PMID 9664154 DOI: 10.1097/00062752-199805000-00003  0.41
1998 Gleadle JM, Ratcliffe PJ. Hypoxia and the regulation of gene expression. Molecular Medicine Today. 4: 122-9. PMID 9575495 DOI: 10.1016/S1357-4310(97)01198-2  0.416
1998 Wood SM, Wiesener MS, Yeates KM, Okada N, Pugh CW, Maxwell PH, Ratcliffe PJ. Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression. The Journal of Biological Chemistry. 273: 8360-8. PMID 9525945 DOI: 10.1074/Jbc.273.14.8360  0.445
1998 Ratcliffe PJ, O'Rourke JF, Maxwell PH, Pugh CW. Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression. The Journal of Experimental Biology. 201: 1153-62. PMID 9510527 DOI: 10.1242/jeb.201.8.1153  0.393
1998 Wiesener M, Turley H, Allen W, Willam C, Eckardt K, Talks K, Wood S, Gatter K, Harris A, Pugh C, Ratcliffe P, Maxwell P. Induction of Endothelial PAS Domain Protein-1 by Hypoxia: Characterization and Comparison With Hypoxia-Inducible Factor-1α Blood. 92: 2260-2268. DOI: 10.1182/Blood.V92.7.2260.2260_2260_2268  0.411
1998 Kambe T, Tada J, Chikuma M, Masuda S, Nagao M, Tsuchiya T, Ratcliffe PJ, Sasaki R. Embryonal Carcinoma P19 Cells Produce Erythropoietin Constitutively But Express Lactate Dehydrogenase in an Oxygen-Dependent Manner Blood. 91: 1185-1195. DOI: 10.1182/Blood.V91.4.1185  0.383
1998 Wood S, Yeates K, Pugh C, Ratcliffe P. Selection of a Mutant Cell Line Defective in Hypoxia Inducible Factor Alpha (HIF-1α) Clinical Science. 94: 1P-1P. DOI: 10.1042/Cs094001Pa  0.357
1998 Carmeliet P, Dor Y, Herbert J, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, Koch CJ, Ratcliffe P, Moons L, Jain RK, Collen D, et al. Erratum: Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis Nature. 395: 525-525. DOI: 10.1038/26791  0.347
1997 O'Rourke JF, Dachs GU, Gleadle JM, Maxwell PH, Pugh CW, Stratford IJ, Wood SM, Ratcliffe PJ. Hypoxia response elements. Oncology Research. 9: 327-32. PMID 9406238  0.386
1997 Maxwell PH, Ferguson DJ, Nicholls LG, Johnson MH, Ratcliffe PJ. The interstitial response to renal injury: fibroblast-like cells show phenotypic changes and have reduced potential for erythropoietin gene expression. Kidney International. 52: 715-24. PMID 9291192 DOI: 10.1038/Ki.1997.387  0.314
1997 Maxwell PH, Dachs GU, Gleadle JM, Nicholls LG, Harris AL, Stratford IJ, Hankinson O, Pugh CW, Ratcliffe PJ. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proceedings of the National Academy of Sciences of the United States of America. 94: 8104-9. PMID 9223322 DOI: 10.1073/Pnas.94.15.8104  0.394
1997 Dachs GU, Patterson AV, Firth JD, Ratcliffe PJ, Townsend KM, Stratford IJ, Harris AL. Targeting gene expression to hypoxic tumor cells. Nature Medicine. 3: 515-20. PMID 9142119 DOI: 10.1038/Nm0597-515  0.397
1997 Pugh CW, O'Rourke JF, Nagao M, Gleadle JM, Ratcliffe PJ. Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit. The Journal of Biological Chemistry. 272: 11205-14. PMID 9111021 DOI: 10.1074/Jbc.272.17.11205  0.426
1997 Ratcliffe PJ, Ebert BL, Firth JD, Gleadle JM, Maxwell PH, Nagao M, O'Rourke JF, Pugh CW, Wood SM. Oxygen regulated gene expression: erythropoietin as a model system. Kidney International. 51: 514-26. PMID 9027732 DOI: 10.1038/Ki.1997.72  0.56
1997 Gleadle JM, Ratcliffe PJ. Induction of hypoxia-inducible factor-1, erythropoietin, vascular endothelial growth factor, and glucose transporter-1 by hypoxia: evidence against a regulatory role for Src kinase. Blood. 89: 503-9. PMID 9002952  0.332
1997 O'Rourke JF, Pugh CW, Bartlett SM, Ratcliffe PJ. Identification of hypoxically inducible mRNAs in HeLa cells using differential-display PCR. Role of hypoxia-inducible factor-1. European Journal of Biochemistry. 241: 403-10. PMID 8917436 DOI: 10.1111/J.1432-1033.1996.00403.X  0.452
1997 Gleadle JM, Ratcliffe PJ. Induction of Hypoxia-Inducible Factor-1, Erythropoietin, Vascular Endothelial Growth Factor, and Glucose Transporter-1 by Hypoxia: Evidence Against a Regulatory Role for Src Kinase Blood. 89: 503-509. DOI: 10.1182/Blood.V89.2.503  0.44
1996 Nagao M, Ebert BL, Ratcliffe PJ, Pugh CW. Drosophila melanogaster SL2 cells contain a hypoxically inducible DNA binding complex which recognises mammalian HIF-binding sites. Febs Letters. 387: 161-6. PMID 8674541 DOI: 10.1016/0014-5793(96)00484-X  0.57
1996 Wood SM, Gleadle JM, Pugh CW, Hankinson O, Ratcliffe PJ. The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxie induction of gene expression: Studies in arnt-deficient cells Journal of Biological Chemistry. 271: 15117-15123. PMID 8662957 DOI: 10.1074/Jbc.271.25.15117  0.458
1996 Ebert BL, Gleadle JM, O'Rourke JF, Bartlett SM, Poulton J, Ratcliffe PJ. Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: similarities with the regulation of erythropoietin. The Biochemical Journal. 809-14. PMID 8611159 DOI: 10.1042/Bj3130809  0.587
1996 Ritthaler T, Göpfert T, Firth JD, Ratcliffe PJ, Kramer BK, Kurtz A. Influence of hypoxia on hepatic and renal endothelin gene expression PflüGers Archiv: European Journal of Physiology. 431: 587-593. PMID 8596703 DOI: 10.1007/Bf02191907  0.319
1996 Gleadle JM, Ebert BL, Ratcliffe PJ. Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia. Implications for the mechanism of oxygen sensing. European Journal of Biochemistry. 234: 92-9. PMID 8529674 DOI: 10.1111/J.1432-1033.1995.092_C.X  0.583
1996 Ebert BL, Firth JD, Ratcliffe PJ. Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences. The Journal of Biological Chemistry. 270: 29083-9. PMID 7493931 DOI: 10.1074/Jbc.270.49.29083  0.566
1995 Firth JD, Ebert BL, Ratcliffe PJ. Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements. The Journal of Biological Chemistry. 270: 21021-7. PMID 7673128 DOI: 10.1074/Jbc.270.36.21021  0.611
1995 Ratcliffe PJ, Ebert BL, Ferguson DJ, Firth JD, Gleadle JM, Maxwell PH, Pugh CW. Regulation of the erythropoietin gene. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 18-27. PMID 7644101 DOI: 10.1093/Ndt/10.Supp2.18  0.504
1995 Gleadle JM, Ebert BL, Firth JD, Ratcliffe PJ. Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents. The American Journal of Physiology. 268: C1362-8. PMID 7541940 DOI: 10.1152/Ajpcell.1995.268.6.C1362  0.583
1995 Gleadle J, Ebert B, Firth J, Ratcliffe P. Oxygen Sensing and Vascular Growth Factor Gene Expression: Comparison with Erythropoietin Regulation Clinical Science. 88. DOI: 10.1042/Cs088002Pa  0.565
1994 Maxwell PH, Osmond MK, Pugh CW, Heryet A, Nicholls LG, Tan CC, Doe BG, Ferguson DJ, Johnson MH, Ratcliffe PJ. Identification of the renal erythropoietin-producing cells using transgenic mice. Kidney International. 44: 1149-62. PMID 8264149 DOI: 10.1038/Ki.1993.362  0.316
1994 Eckardt KU, Pugh CW, Meier M, Tan CC, Ratcliffe PJ, Kurtz A, Caro J, Goldwasser E, Fandrey J, Rich IN, Koury MJ, Jelkmann WEB, Epstein FH. Production of erythropoietin by liver cells in vivo and in vitro Annals of the New York Academy of Sciences. 718: 50-63. PMID 8185251 DOI: 10.1111/J.1749-6632.1994.Tb55703.X  0.331
1994 Pugh CW, Ebert BL, Ebrahim O, Maxwell PH, Ratcliffe PJ, Caro J, Acker H, Goldwasser E. Analysis of cis-acting sequences required for operation of the erythropoietin 3' enhancer in different cell lines Annals of the New York Academy of Sciences. 718: 31-40. PMID 8185238 DOI: 10.1111/J.1749-6632.1994.Tb55701.X  0.456
1994 Pugh CW, Ebert BL, Ebrahim O, Ratcliffe PJ. Characterisation of functional domains within the mouse erythropoietin 3' enhancer conveying oxygen-regulated responses in different cell lines. Biochimica Et Biophysica Acta. 1217: 297-306. PMID 8148375 DOI: 10.1016/0167-4781(94)90289-5  0.537
1994 Firth JD, Ebert BL, Pugh CW, Ratcliffe PJ. Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer. Proceedings of the National Academy of Sciences of the United States of America. 91: 6496-500. PMID 8022811 DOI: 10.1073/Pnas.91.14.6496  0.591
1993 Eckardt KU, Koury ST, Tan CC, Schuster SJ, Kaissling B, Ratcliffe PJ, Kurtz A. Distribution of erythropoietin producing cells in rat kidneys during hypoxic hypoxia. Kidney International. 43: 815-23. PMID 8479117 DOI: 10.1038/Ki.1993.115  0.376
1993 Maxwell PH, Pugh CW, Ratcliffe PJ. Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism. Proceedings of the National Academy of Sciences of the United States of America. 90: 2423-7. PMID 8460154 DOI: 10.1073/Pnas.90.6.2423  0.447
1993 Eckardt K, Pugh CW, Ratcliffe PJ, Kurtz A. Oxygen-dependent expression of the erythropoietin gene in rat hepatocytes in vitro. PflüGers Archiv: European Journal of Physiology. 423: 356-364. PMID 8351193 DOI: 10.1007/Bf00374928  0.38
1992 Eckardt KU, LeHir M, Tan CC, Ratcliffe PJ, Kaissling B, Kurtz A. Renal innervation plays no role in oxygen-dependent control of erythropoietin mRNA levels. The American Journal of Physiology. 263: F925-30. PMID 1443180 DOI: 10.1152/Ajprenal.1992.263.5.F925  0.304
1992 Tan CC, Ratcliffe PJ. Rapid oxygen-dependent changes in erythropoietin mRNA in perfused rat kidneys: Evidence against mediation by cAMP Kidney International. 41: 1581-1587. PMID 1323727 DOI: 10.1038/Ki.1992.228  0.361
1991 Pugh CW, Tan CC, Jones RW, Ratcliffe PJ. Functional analysis of an oxygen-regulated transcriptional enhancer typing 3′ to the mouse erythropoietin gene Proceedings of the National Academy of Sciences of the United States of America. 88: 10553-10557. PMID 1961720 DOI: 10.1073/Pnas.88.23.10553  0.395
1991 Tan CC, Ratcliffe PJ. Effect of inhibitors of oxidative phosphorylation on erythropoietin mRNA in isolated perfused rat kidneys American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 261. PMID 1750523 DOI: 10.1152/Ajprenal.1991.261.6.F982  0.344
1990 Ratcliffe PJ, Jones RW, Phillips RE, Nicholls LG, Bell JI. Oxygen-dependent modulation of erythropoietin mRNA levels in isolated rat kidneys studied by RNase protection. The Journal of Experimental Medicine. 172: 657-60. PMID 2373996 DOI: 10.1084/Jem.172.2.657  0.331
1989 Endre ZH, Ratcliffe PJ, Tange JD, Ferguson DJP, Radda GK, Ledingham JGG. Erythrocytes alter the pattern of renal hypoxic injury: predominance of proximal tubular injury with moderate hypoxia Clinical Science. 76: 19-29. PMID 2920531 DOI: 10.1042/Cs0760019  0.308
1989 Ratcliffe PJ, Endre ZH, Tange JD, Ledingham JGG. Ischaemic acute renal failure: Why does it occur? Nephron. 52: 1-5. PMID 2651944 DOI: 10.1159/000185573  0.337
1988 Ratcliffe PJ, Endre ZH, Scheinman SJ, Tange JD, Ledingham JGG, Radda GK. 31P nuclear magnetic resonance study of steady-state adenosine 5'-triphosphate levels during graded hypoxia in the isolated perfused rat kidney Clinical Science. 74: 437-448. PMID 3356115 DOI: 10.1042/Cs0740437  0.361
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