Paul Yen - Publications

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114 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Rajak S, Xie S, Tewari A, Raza S, Yajun W, Bay BH, Yen PM, Sinha RA. MTORC1 inhibition drives crinophagic degradation of glucagon. Molecular Metabolism. 101286. PMID 34224916 DOI: 10.1016/j.molmet.2021.101286  0.01
2021 Widjaja AA, Dong J, Adami E, Viswanathan S, Ng B, Pakkiri LS, Chothani SP, Singh BK, Lim WW, Zhou J, Shekeran SG, Tan J, Lim SY, Goh J, Wang M, ... ... Yen PM, et al. Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury. Science Translational Medicine. 13. PMID 34108253 DOI: 10.1126/scitranslmed.aba8146  0.01
2021 Bruinstroop E, Zhou J, Tripathi M, Yau WW, Boelen A, Singh BK, Yen PM. Early induction of hepatic deiodinase type 1 inhibits hepatosteatosis during NAFLD progression. Molecular Metabolism. 101266. PMID 34098145 DOI: 10.1016/j.molmet.2021.101266  0.01
2021 Zhou J, Gauthier K, Ho JP, Lim A, Zhu XG, Han CR, Sinha RA, Cheng SY, Yen PM. Thyroid hormone receptor-α regulates autophagy, mitochondrial biogenesis, and fatty acid utilization in skeletal muscle. Endocrinology. PMID 34086893 DOI: 10.1210/endocr/bqab112  0.01
2021 Yau WW, Wong KA, Zhou J, Thimmukonda NK, Wu Y, Bay BH, Singh BK, Yen PM. Chronic cold exposure induces autophagy to promote fatty acid oxidation, mitochondrial turnover, and thermogenesis in brown adipose tissue. Iscience. 24: 102434. PMID 34027318 DOI: 10.1016/j.isci.2021.102434  0.01
2021 Yen P, Bucevska M, Reilly C, Verchere C. Can Tissue Expansion Reconstruction in the Trunk of Children Increase the Risk of Scoliosis? Plastic Surgery (Oakville, Ont.). 29: 88-97. PMID 34026671 DOI: 10.1177/2292550320933671  0.04
2021 Zhou J, Singh BK, Ho JP, Lim A, Bruinstroop E, Ohba K, Sinha RA, Yen PM. mediator subunit is a key regulator of hepatic autophagy and lipid metabolism. Autophagy. 1-19. PMID 33734012 DOI: 10.1080/15548627.2021.1899691  0.01
2021 Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, ... ... Yen PM, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 1-382. PMID 33634751 DOI: 10.1080/15548627.2020.1797280  0.01
2021 Chakraborty S, Ong WK, Yau WWY, Zhou Z, Bhanu Prakash KN, Toh SA, Han W, Yen PM, Sugii S. CD10 marks non-canonical PPARγ-independent adipocyte maturation and browning potential of adipose-derived stem cells. Stem Cell Research & Therapy. 12: 109. PMID 33541392 DOI: 10.1186/s13287-021-02179-y  0.01
2021 Setiawan I, Sanjaya A, Lesmana R, Yen PM, Goenawan H. Hippo pathway effectors YAP and TAZ and their association with skeletal muscle ageing. Journal of Physiology and Biochemistry. PMID 33495890 DOI: 10.1007/s13105-021-00787-z  0.01
2021 Zhou J, Tripathi M, Sinha RA, Singh BK, Yen PM. Gut microbiota and their metabolites in the progression of non-alcoholic fatty liver disease. Hepatoma Research. 7: 11. PMID 33490737 DOI: 10.20517/2394-5079.2020.134  0.01
2021 Dong J, Viswanathan S, Adami E, Singh BK, Chothani SP, Ng B, Lim WW, Zhou J, Tripathi M, Ko NSJ, Shekeran SG, Tan J, Lim SY, Wang M, Lio PM, ... Yen PM, et al. Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH. Nature Communications. 12: 66. PMID 33397952 DOI: 10.1038/s41467-020-20303-z  0.01
2020 Chaves C, Bruinstroop E, Refetoff S, Yen PM, Anselmo JD. INCREASED HEPATIC FAT CONTENT IN PATIENTS WITH RESISTANCE TO THYROID HORMONE BETA. Thyroid : Official Journal of the American Thyroid Association. PMID 33353459 DOI: 10.1089/thy.2020.0651  0.01
2020 Tripathi M, Yen PM, Singh BK. Protocol to Generate Senescent Cells from the Mouse Hepatic Cell Line AML12 to Study Hepatic Aging. Star Protocols. 1: 100064. PMID 33111102 DOI: 10.1016/j.xpro.2020.100064  0.01
2020 Rajak S, Iannucci LF, Zhou J, Anjum B, George N, Singh BK, Ghosh S, Yen PM, Sinha RA. Loss of ULK1 Attenuates Cholesterogenic Gene Expression in Mammalian Hepatic Cells. Frontiers in Cell and Developmental Biology. 8: 523550. PMID 33083385 DOI: 10.3389/fcell.2020.523550  0.01
2020 Rajak S, Raza S, Tewari A, Yadav S, Ghosh S, Yen PM, Sinha RA. Autophagic protein ULK1 regulates FOXM1 signalling in human hepatoma cells. Biochemical and Biophysical Research Communications. PMID 32900486 DOI: 10.1016/j.bbrc.2020.08.068  0.01
2020 Singh BK, Tripathi M, Sandireddy R, Tikno K, Zhou J, Yen PM. Decreased autophagy and fuel switching occur in a senescent hepatic cell model system. Aging. 12. PMID 32712601 DOI: 10.18632/aging.103740  0.01
2020 Yau WW, Yen PM. Thermogenesis in Adipose Tissue Activated by Thyroid Hormone. International Journal of Molecular Sciences. 21. PMID 32344721 DOI: 10.3390/ijms21083020  0.01
2020 Sinha RA, Rajak S, Singh BK, Yen PM. Hepatic Lipid Catabolism via PPARα-Lysosomal Crosstalk. International Journal of Molecular Sciences. 21. PMID 32244266 DOI: 10.3390/ijms21072391  0.01
2020 Tripathi M, Yen PM, Singh BK. Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases. International Journal of Molecular Sciences. 21. PMID 32121253 DOI: 10.3390/ijms21051645  0.01
2020 Sinha RA, Bruinstroop E, Singh BK, Yen PM. Thyroid hormones and thyromimetics: A new approach to NASH? Hepatology (Baltimore, Md.). PMID 32104916 DOI: 10.1002/hep.31204  0.01
2019 Yavarow ZA, Kang HR, Waskowicz LR, Bay BH, Young SP, Yen PM, Koeberl DD. Fenofibrate rapidly decreases hepatic lipid and glycogen storage in neonatal mice with glycogen storage disease type Ia. Human Molecular Genetics. PMID 31816064 DOI: 10.1093/hmg/ddz290  0.01
2019 Farah BL, Yen PM, Koeberl DD. Links between autophagy and disorders of glycogen metabolism - Perspectives on pathogenesis and possible treatments. Molecular Genetics and Metabolism. PMID 31787497 DOI: 10.1016/j.ymgme.2019.11.005  0.01
2019 Zhou J, Parker DC, White JP, Lim A, Huffman KM, Ho JP, Yen PM, Kraus WE. Thyroid Hormone Status Regulates Skeletal Muscle Response to Chronic Motor Nerve Stimulation. Frontiers in Physiology. 10: 1363. PMID 31736784 DOI: 10.3389/fphys.2019.01363  0.01
2019 Duntas LH, Yen PM. Diagnosis and treatment of hypothyroidism in the elderly. Endocrine. PMID 31482381 DOI: 10.1007/s12020-019-02067-9  0.01
2019 Sinha RA, Bruinstroop E, Singh BK, Yen PM. Non-alcoholic fatty liver disease and hypercholesterolemia: Roles of thyroid hormones, metabolites, and agonists. Thyroid : Official Journal of the American Thyroid Association. PMID 31389309 DOI: 10.1089/thy.2018.0664  0.01
2019 Zhou J, Waskowicz LR, Lim A, Liao XH, Lian B, Masamune H, Refetoff S, Tran B, Koeberl DD, Yen PM. A liver-specific thyromimetic, VK2809, decreases hepatosteatosis in glycogen storage disease type Ia (GSD Ia). Thyroid : Official Journal of the American Thyroid Association. PMID 31337282 DOI: 10.1089/Thy.2019.0007  0.01
2019 Meng F, Li E, Yen PM, Leow MKS. Hyperthyroidism in the personalized medicine era: the rise of mathematical optimization. Journal of the Royal Society, Interface. 16: 20190083. PMID 31238837 DOI: 10.1098/rsif.2019.0083  0.01
2019 Widjaja AA, Singh BK, Adami E, Viswanathan S, Dong J, D'Agostino GA, Ng B, Lim WW, Tan J, Paleja BS, Tripathi M, Lim SY, Shekeran SG, Chothani SP, Rabes A, ... ... Yen PM, et al. Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Non-Alcoholic Steatohepatitis. Gastroenterology. PMID 31078624 DOI: 10.1053/j.gastro.2019.05.002  0.01
2019 Siong Tan HW, Anjum B, Shen HM, Ghosh S, Yen PM, Sinha RA. Lysosomal inhibition attenuates peroxisomal gene transcription via suppression of PPARA and PPARGC1A levels. Autophagy. 1-5. PMID 31032705 DOI: 10.1080/15548627.2019.1609847  0.01
2019 Yen PP, Wiseman SM. Poor Readability of Online Patient Resources Regarding Sentinel Lymph Node Biopsy for Melanoma. Cureus. 11: e3877. PMID 30899628 DOI: 10.7759/cureus.3877  0.01
2019 Okamoto H, Hamao S, Eguchi R, Goto H, Takabayashi Y, Yen PY, Liang LU, Chou CW, Hoffmann G, Gohda S, Sugino H, Liao YF, Ishii H, Kubozono Y. Synthesis of the extended phenacene molecules, [10]phenacene and [11]phenacene, and their performance in a field-effect transistor. Scientific Reports. 9: 4009. PMID 30850618 DOI: 10.1038/s41598-019-39899-4  0.01
2019 Zhou J, Ng B, Ko NSJ, Fiedler LR, Khin E, Lim A, Sahib NE, Wu Y, Chothani SP, Schafer S, Bay BH, Sinha RA, Cook SA, Yen PM. Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo. Human Molecular Genetics. PMID 30715350 DOI: 10.1093/hmg/ddz033  0.01
2018 Zhou W, Ma D, Sun AX, Tran HD, Ma DL, Singh BK, Zhou J, Zhang J, Wang D, Zhao Y, Yen PM, Goh E, Tan EK. PD-linked CHCHD2 mutations impair CHCHD10 and MICOS complex leading to mitochondria dysfunction. Human Molecular Genetics. PMID 30496485 DOI: 10.1093/hmg/ddy413  0.01
2018 Singh BK, Sinha RA, Yen PM. Novel Transcriptional Mechanisms for Regulating Metabolism by Thyroid Hormone. International Journal of Molecular Sciences. 19. PMID 30360449 DOI: 10.3390/ijms19103284  0.01
2018 Cheong A, Low JJA, Lim A, Yen PM, Woon ECY. A fluorescent methylation-switchable probe for highly sensitive analysis of FTO -methyladenosine demethylase activity in cells. Chemical Science. 9: 7174-7185. PMID 30288236 DOI: 10.1039/c8sc02163e  0.01
2018 Waskowicz LR, Zhou J, Landau DJ, Brooks ED, Lim A, Yavarow ZA, Kudo T, Zhang H, Wu Y, Grant S, Young SP, Huat BB, Yen PM, Koeberl DD. Bezafibrate induces autophagy and improves hepatic lipid metabolism in glycogen storage disease type Ia. Human Molecular Genetics. PMID 30256948 DOI: 10.1093/hmg/ddy343  0.01
2018 Yau WW, Singh BK, Lesmana R, Zhou J, Sinha RA, Wong KA, Wu Y, Bay BH, Sugii S, Sun L, Yen PM. Thyroid hormone (T) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy. Autophagy. 1-20. PMID 30209975 DOI: 10.1080/15548627.2018.1511263  0.01
2018 Singh BK, Sinha RA, Tripathi M, Mendoza A, Ohba K, Sy JAC, Xie SY, Zhou J, Ho JP, Chang CY, Wu Y, Giguère V, Bay BH, Vanacker JM, Ghosh S, ... ... Yen PM, et al. Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function. Science Signaling. 11. PMID 29945885 DOI: 10.1126/Scisignal.Aam5855  0.01
2018 Zhou J, Sinha RA, Lesmana R, Yau WWY, Yen PM. Pharmacological Inhibition of Lysosomal Activity as a Method For Monitoring Thyroid Hormone-induced Autophagic Flux in Mammalian Cells In Vitro. Methods in Molecular Biology (Clifton, N.J.). 1801: 111-122. PMID 29892821 DOI: 10.1007/978-1-4939-7902-8_11  0.01
2018 Bruinstroop E, Dalan R, Yang C, Bee YM, Chandran K, Cho LW, Soh SB, Teo EK, Toh SA, Leow MKS, Sinha RA, Sadananthan SA, Michael N, Stapleton H, Leung C, ... ... Yen PM, et al. Low Dose Levothyroxine Reduces Intrahepatic Lipid Content in Patients with Type 2 Diabetes Mellitus and NAFLD. The Journal of Clinical Endocrinology and Metabolism. PMID 29718334 DOI: 10.1210/Jc.2018-00475  0.01
2018 Sinha RA, Singh BK, Yen PM. Direct effects of thyroid hormones on hepatic lipid metabolism. Nature Reviews. Endocrinology. PMID 29472712 DOI: 10.1038/nrendo.2018.10  0.01
2017 Wang ME, Singh BK, Hsu MC, Huang C, Yen PM, Wu LS, Jong DS, Chiu CH. Increasing Dietary Medium-Chain Fatty Acid Ratio Mitigates High-fat Diet-Induced Non-Alcoholic Steatohepatitis by Regulating Autophagy. Scientific Reports. 7: 13999. PMID 29070903 DOI: 10.1038/s41598-017-14376-y  0.01
2017 Singh BK, Yen PM. A clinician's guide to understanding resistance to thyroid hormone due to receptor mutations in the TRα and TRβ isoforms. Clinical Diabetes and Endocrinology. 3: 8. PMID 28932413 DOI: 10.1186/s40842-017-0046-z  0.01
2017 Farah BL, Landau DJ, Wu Y, Sinha RA, Loh A, Bay BH, Koeberl DD, Yen PM. Renal endoplasmic reticulum stress is coupled to impaired autophagy in a mouse model of GSD Ia. Molecular Genetics and Metabolism. PMID 28888852 DOI: 10.1016/j.ymgme.2017.08.013  0.01
2017 Iannucci LF, Cioffi F, Senese R, Goglia F, Lanni A, Yen PM, Sinha RA. Metabolomic analysis shows differential hepatic effects of T2 and T3 in rats after short-term feeding with high fat diet. Scientific Reports. 7: 2023. PMID 28515456 DOI: 10.1038/s41598-017-02205-1  0.01
2017 Flamant F, Cheng SY, Hollenberg AN, Moeller LC, Samarut J, Wondisford FE, Yen PM, Refetoff S. Thyroid hormone signaling pathways. Time for a more precise nomenclature. Endocrinology. PMID 28472304 DOI: 10.1210/En.2017-00250  0.01
2017 Butler MS, Roshan-Moniri M, Hsing M, Lau D, Kim A, Yen P, Mroczek M, Nouri M, Lien S, Axerio-Cilies P, Dalal K, Yau C, Ghaidi F, Guo Y, Yamazaki T, et al. Discovery and characterization of small molecules targeting the DNA-binding ETS domain of ERG in prostate cancer. Oncotarget. PMID 28465491 DOI: 10.18632/Oncotarget.17124  0.01
2017 Ohba K, Sinha RA, Leow MK, Iannucci LF, Singh BK, Zhou J, Kovalik JP, Liao XH, Refetoff S, Sng JCG, Yen PM. Changes in hepatic TRβ protein expression, lipogenic gene expression, and long chain acylcarnitine levels during chronic hyperthyroidism and T3 withdrawal in a mouse model. Thyroid : Official Journal of the American Thyroid Association. PMID 28457184 DOI: 10.1089/Thy.2016.0456  0.01
2017 Farah BL, Sinha RA, Wu Y, Singh BK, Lim A, Hirayama M, Landau DJ, Bay BH, Koeberl DD, Yen PM. Hepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa). Scientific Reports. 7: 44408. PMID 28317891 DOI: 10.1038/srep44408  0.01
2017 Zhou J, Chong SY, Lim A, Singh BK, Sinha RA, Salmon AB, Yen PM. Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging. Aging. PMID 28238968 DOI: 10.18632/aging.101181  0.01
2017 Singh BK, Sinha RA, Ohba K, Yen PM. Role of thyroid hormone in hepatic gene regulation, chromatin remodeling, and autophagy. Molecular and Cellular Endocrinology. PMID 28216439 DOI: 10.1016/j.mce.2017.02.018  0.01
2017 Butler MS, Roshan-Moniri M, Hsing M, Lau D, Kim A, Yen P, Mroczek M, Nouri M, Lien S, Axerio-Cilies P, Dalal K, Yau C, Ghaidi F, Guo Y, Yamazaki T, et al. Abstract 130: Discovery and characterization of small molecules targeting the DNA-binding ETS domain of ERG in prostate cancer Cancer Research. 77: 130-130. DOI: 10.1158/1538-7445.Am2017-130  0.01
2017 Yen P, Jin C, Dormuth C, Wright JM. Time course for blood pressure lowering of angiotensin receptor blockers Cochrane Database of Systematic Reviews. DOI: 10.1002/14651858.Cd012571  0.01
2016 Courtade JA, Wang EY, Yen P, Dai DL, Soukhatcheva G, Orban PC, Verchere CB. Loss of prohormone convertase 2 promotes beta cell dysfunction in a rodent transplant model expressing human pro-islet amyloid polypeptide. Diabetologia. PMID 27999871 DOI: 10.1007/S00125-016-4174-2  0.01
2016 Tripathi M, Zhang CW, Singh BK, Sinha RA, Moe KT, DeSilva DA, Yen PM. Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation. Cell Death & Disease. 7: e2513. PMID 27929536 DOI: 10.1038/cddis.2016.374  0.01
2016 Sinha RA, Singh BK, Yen PM. Reciprocal crosstalk between autophagic and endocrine signaling in metabolic homeostasis. Endocrine Reviews. er20161103. PMID 27901588 DOI: 10.1210/er.2016-1103  0.01
2016 Iannucci LF, Sun J, Singh BK, Zhou J, Kaddai VA, Lanni A, Yen PM, Sinha RA. Corrigendum to "Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells" [Biochem. Biophys. Res. Commun. 480 (2016) 461-467]. Biochemical and Biophysical Research Communications. PMID 27899181 DOI: 10.1016/j.bbrc.2016.11.116  0.01
2016 Sinha RA, Singh BK, Zhou J, Xie S, Farah BL, Lesmana R, Ohba K, Tripathi M, Ghosh S, Hollenberg AN, Yen PM. Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells. Autophagy. 0. PMID 27846372 DOI: 10.1080/15548627.2016.1235123  0.01
2016 Iannucci LF, Sun J, Singh BK, Zhou J, Kaddai VA, Lanni A, Yen PM, Sinha RA. Short chain fatty acids induce UCP2-mediated autophagy in hepatic cells. Biochemical and Biophysical Research Communications. PMID 27773823 DOI: 10.1016/j.bbrc.2016.10.072  0.01
2016 Lim A, Zhou J, Sinha RA, Singh BK, Ghosh S, Lim KH, Kah-Hoe Chow P, Woon EC, Yen PM. Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity. Biochemical and Biophysical Research Communications. PMID 27651333 DOI: 10.1016/j.bbrc.2016.09.086  1
2016 Yen PM. TSHβv-A New Bone to Pick. Endocrinology. 157: 3402-4. PMID 27580809 DOI: 10.1210/en.2016-1519  0.01
2016 Chng CL, Lim AY, Tan HC, Kovalik JP, Tham KW, Bee YM, Lim W, Acharyya S, Lai OF, Chong MF, Yen PM. Physiological and metabolic changes during the transition from hyperthyroidism to euthyroidism in Graves' disease. Thyroid : Official Journal of the American Thyroid Association. PMID 27465032 DOI: 10.1089/thy.2015.0602  1
2016 Sinha RA, Yen PM. Thyroid hormone-mediated autophagy and mitochondrial turnover in NAFLD. Cell & Bioscience. 6: 46. PMID 27437098 DOI: 10.1186/s13578-016-0113-7  1
2016 Ohba K, Khee-Shing Leow M, Singh BK, Sinha RA, Lesmana R, Liao XH, Ghosh S, Refetoff S, Ghee Sng JC, Yen PM. Desensitization and incomplete recovery of hepatic target genes after chronic thyroid hormone treatment and withdrawal in male adult mice. Endocrinology. en20151848. PMID 26866609 DOI: 10.1210/En.2015-1848  1
2015 Lesmana R, Sinha RA, Singh BK, Zhou J, Ohba K, Wu Y, Yau WW, Bay BH, Yen PM. Thyroid Hormone Stimulation of Autophagy Is Essential for Mitochondrial Biogenesis and Activity in Skeletal Muscle. Endocrinology. en20151632. PMID 26562261 DOI: 10.1210/en.2015-1632  1
2015 Farah BL, Landau DJ, Sinha RA, Brooks ED, Wu Y, Fung SY, Tanaka T, Hirayama M, Bay BH, Koeberl DD, Yen PM. Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency. Journal of Hepatology. PMID 26462884 DOI: 10.1016/j.jhep.2015.10.008  1
2015 Singh BK, Sinha RA, Zhou J, Tripathi M, Ohba K, Wang ME, Astapova I, Ghosh S, Hollenberg AN, Gauthier K, Yen PM. Hepatic FOXO1 target genes are co-regulated by thyroid hormone via RICTOR deacetylation and MTORC2-AKT inhibition. The Journal of Biological Chemistry. PMID 26453307 DOI: 10.1074/jbc.M115.668673  1
2015 Yen PM. Classical nuclear hormone receptor activity as a mediator of complex biological responses: a look at health and disease. Best Practice & Research. Clinical Endocrinology & Metabolism. 29: 517-28. PMID 26303080 DOI: 10.1016/j.beem.2015.07.005  0.01
2015 Sinha RA, Singh BK, Zhou J, Wu Y, Farah BL, Ohba K, Lesmana R, Gooding J, Bay BH, Yen PM. Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling. Autophagy. 0. PMID 26103054 DOI: 10.1080/15548627.2015.1061849  1
2015 Yen PM. Unliganded TRs regulate growth and developmental timing during early embryogenesis: evidence for a dual function mechanism of TR action. Cell & Bioscience. 5: 8. PMID 25973174 DOI: 10.1186/2045-3701-5-8  0.01
2015 Zhou J, Yong WP, Yap CS, Vijayaraghavan A, Sinha RA, Singh BK, Xiu S, Manesh S, Ngo A, Lim A, Ang C, Xie C, Wong FY, Lin SJ, Wan WK, ... ... Yen PM, et al. An integrative approach identified genes associated with drug response in gastric cancer. Carcinogenesis. 36: 441-51. PMID 25742747 DOI: 10.1093/carcin/bgv014  1
2015 Roshan-Moniri M, Hsing M, Butler MS, Lau D, Axerio-Cilies P, Yen P, Kim A, Lien S, Mroczek M, Ma D, Li H, Guo Y, Ban F, Ghaidi F, LeBlanc E, et al. Abstract 1652: Therapeutic targeting of ETS factor ERG for the treatment of prostate cancer Cancer Research. 75: 1652-1652. DOI: 10.1158/1538-7445.Am2015-1652  0.01
2015 Butler MS, Hsing M, Moniri MR, Lau D, Yen P, Kim A, Lien S, Mroczek M, Ghaidi F, LeBlanc E, McIntosh L, Cox M, Cherkasov A, Rennie PS. Abstract 1648: Targeting ETS factor ETV4 as a novel therapeutic for the management of breast and prostate cancer Cancer Research. 75: 1648-1648. DOI: 10.1158/1538-7445.Am2015-1648  0.01
2014 Sinha RA, Singh BK, Yen PM. Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism. Trends in Endocrinology and Metabolism: Tem. 25: 538-45. PMID 25127738 DOI: 10.1016/j.tem.2014.07.001  0.01
2014 Farah BL, Sinha RA, Wu Y, Singh BK, Zhou J, Bay BH, Yen PM. β-Adrenergic agonist and antagonist regulation of autophagy in HepG2 cells, primary mouse hepatocytes, and mouse liver. Plos One. 9: e98155. PMID 24950230 DOI: 10.1371/journal.pone.0098155  1
2014 Refetoff S, Bassett JH, Beck-Peccoz P, Bernal J, Brent G, Chatterjee K, De Groot LJ, Dumitrescu AM, Jameson JL, Kopp PA, Murata Y, Persani L, Samarut J, Weiss RE, Williams GR, ... Yen PM, et al. Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism. European Thyroid Journal. 3: 7-9. PMID 24847459 DOI: 10.1159/000358180  0.01
2014 Refetoff S, Bassett JH, Beck-Peccoz P, Bernal J, Brent G, Chatterjee K, De Groot LJ, Dumitrescu AM, Jameson JL, Kopp PA, Murata Y, Persani L, Samarut J, Weiss RE, Williams GR, ... Yen PM, et al. Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism. The Journal of Clinical Endocrinology and Metabolism. 99: 768-70. PMID 24823702 DOI: 10.1210/Jc.2013-3393  1
2014 Aw DK, Sinha RA, Xie SY, Yen PM. Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells. Biochemical and Biophysical Research Communications. 447: 569-73. PMID 24735537 DOI: 10.1016/j.bbrc.2014.04.031  1
2014 Aw DK, Sinha RA, Tan HC, Loh LM, Salvatore D, Yen PM. Studies of molecular mechanisms associated with increased deiodinase 3 expression in a case of consumptive hypothyroidism. The Journal of Clinical Endocrinology and Metabolism. 99: 3965-71. PMID 24646062 DOI: 10.1210/jc.2013-3408  0.01
2014 Refetoff S, Bassett JH, Beck-Peccoz P, Bernal J, Brent G, Chatterjee K, De Groot LJ, Dumitrescu AM, Jameson JL, Kopp PA, Murata Y, Persani L, Samarut J, Weiss RE, Williams GR, ... Yen PM, et al. Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism. Thyroid : Official Journal of the American Thyroid Association. 24: 407-9. PMID 24588711 DOI: 10.1089/Thy.2013.3393.Nomen  1
2014 Zhou J, Farah BL, Sinha RA, Wu Y, Singh BK, Bay BH, Yang CS, Yen PM. Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance. Plos One. 9: e87161. PMID 24489859 DOI: 10.1371/journal.pone.0087161  1
2014 Farah BL, Madden L, Li S, Nance S, Bird A, Bursac N, Yen PM, Young SP, Koeberl DD. Adjunctive β2-agonist treatment reduces glycogen independently of receptor-mediated acid α-glucosidase uptake in the limb muscles of mice with Pompe disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 2272-80. PMID 24448824 DOI: 10.1096/Fj.13-244202  1
2014 Sinha RA, Farah BL, Singh BK, Siddique MM, Li Y, Wu Y, Ilkayeva OR, Gooding J, Ching J, Zhou J, Martinez L, Xie S, Bay BH, Summers SA, Newgard CB, ... Yen PM, et al. Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice. Hepatology (Baltimore, Md.). 59: 1366-80. PMID 23929677 DOI: 10.1002/Hep.26667  1
2013 Xie S, Sinha RA, Singh BK, Li GD, Han W, Yen PM. Resveratrol induces insulin gene expression in mouse pancreatic α-cells. Cell & Bioscience. 3: 47. PMID 24330680 DOI: 10.1186/2045-3701-3-47  0.01
2013 Yap CS, Sinha RA, Ota S, Katsuki M, Yen PM. Thyroid hormone negatively regulates CDX2 and SOAT2 mRNA expression via induction of miRNA-181d in hepatic cells. Biochemical and Biophysical Research Communications. 440: 635-9. PMID 24103759 DOI: 10.1016/j.bbrc.2013.09.116  0.01
2013 Singh BK, Sinha RA, Zhou J, Xie SY, You SH, Gauthier K, Yen PM. FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes. The Journal of Biological Chemistry. 288: 30365-72. PMID 23995837 DOI: 10.1074/jbc.M113.504845  1
2013 Wang G, Cao X, Lai S, Luo X, Feng Y, Xia X, Yen PM, Gong J, Hu J. PI3K stimulates DNA synthesis and cell-cycle progression via its p55PIK regulatory subunit interaction with PCNA. Molecular Cancer Therapeutics. 12: 2100-9. PMID 23939377 DOI: 10.1158/1535-7163.MCT-12-0920  0.01
2012 Zhou J, Chen GB, Tang YC, Sinha RA, Wu Y, Yap CS, Wang G, Hu J, Xia X, Tan P, Goh LK, Yen PM. Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library. Bmc Medical Genomics. 5: 34. PMID 22876838 DOI: 10.1186/1755-8794-5-34  0.01
2012 Sinha RA, You SH, Zhou J, Siddique MM, Bay BH, Zhu X, Privalsky ML, Cheng SY, Stevens RD, Summers SA, Newgard CB, Lazar MA, Yen PM. Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy. The Journal of Clinical Investigation. 122: 2428-38. PMID 22684107 DOI: 10.1172/Jci60580  1
2012 Duntas L, Amino N, Hay I, McDermott M, Peeters R, Vaismann M, Ward L, Williams G, San Luis TO, Yen P. Thyroid disorders, noncommunicable diseases that gravely impact public health: a commentary and statement by the Advisory Board of the World Thyroid Federation. Thyroid : Official Journal of the American Thyroid Association. 22: 566-7. PMID 22667451 DOI: 10.1089/Thy.2012.0153  0.01
2011 Voss TC, Schiltz RL, Sung MH, Yen PM, Stamatoyannopoulos JA, Biddie SC, Johnson TA, Miranda TB, John S, Hager GL. Dynamic exchange at regulatory elements during chromatin remodeling underlies assisted loading mechanism. Cell. 146: 544-54. PMID 21835447 DOI: 10.1016/J.Cell.2011.07.006  1
2010 Wang D, Xia X, Weiss RE, Refetoff S, Yen PM. Distinct and histone-specific modifications mediate positive versus negative transcriptional regulation of TSHalpha promoter. Plos One. 5: e9853. PMID 20352046 DOI: 10.1371/Journal.Pone.0009853  1
2010 Culhane JC, Wang D, Yen PM, Cole PA. Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors. Journal of the American Chemical Society. 132: 3164-76. PMID 20148560 DOI: 10.1021/Ja909996P  1
2009 Wang D, Xia X, Liu Y, Oetting A, Walker RL, Zhu Y, Meltzer P, Cole PA, Shi YB, Yen PM. Negative regulation of TSHalpha target gene by thyroid hormone involves histone acetylation and corepressor complex dissociation. Molecular Endocrinology (Baltimore, Md.). 23: 600-9. PMID 19196836 DOI: 10.1210/Me.2008-0389  1
2008 Hu J, Xia X, Cheng A, Wang G, Luo X, Reed MF, Fojo T, Oetting A, Gong J, Yen PM. A peptide inhibitor derived from p55PIK phosphatidylinositol 3-kinase regulatory subunit: a novel cancer therapy. Molecular Cancer Therapeutics. 7: 3719-28. PMID 19074847 DOI: 10.1158/1535-7163.Mct-08-0499  1
2008 Yen PM. Waterboarding is not torture: a physician's response The Lancet. 371: 1838. PMID 18514727 DOI: 10.1016/S0140-6736(08)60795-3  1
2007 Oetting A, Yen PM. New insights into thyroid hormone action. Best Practice & Research. Clinical Endocrinology & Metabolism. 21: 193-208. PMID 17574003 DOI: 10.1016/j.beem.2007.04.004  0.01
2007 Harvey CB, Bassett JH, Maruvada P, Yen PM, Williams GR. The rat thyroid hormone receptor (TR) Deltabeta3 displays cell-, TR isoform-, and thyroid hormone response element-specific actions. Endocrinology. 148: 1764-73. PMID 17218414 DOI: 10.1210/en.2006-1248  0.01
2006 Yen PM. Thyroid hormones and 3,5-diiodothyropropionic acid: New keys for new locks Endocrinology. 147: 1598-1601. PMID 16543378 DOI: 10.1210/en.2006-0074  1
2006 Yen PM, Ando S, Feng X, Liu Y, Maruvada P, Xia X. Thyroid hormone action at the cellular, genomic and target gene levels. Molecular and Cellular Endocrinology. 246: 121-7. PMID 16442701 DOI: 10.1016/j.mce.2005.11.030  0.01
2006 Liu Y, Xia X, Fondell JD, Yen PM. Thyroid hormone-regulated target genes have distinct patterns of coactivator recruitment and histone acetylation. Molecular Endocrinology (Baltimore, Md.). 20: 483-90. PMID 16254015 DOI: 10.1210/me.2005-0101  0.01
2005 Shepshelovich J, Goldstein-Magal L, Globerson A, Yen PM, Rotman-Pikielny P, Hirschberg K. Protein synthesis inhibitors and the chemical chaperone TMAO reverse endoplasmic reticulum perturbation induced by overexpression of the iodide transporter pendrin. Journal of Cell Science. 118: 1577-86. PMID 15784681 DOI: 10.1242/jcs.02294  1
2005 Yen PM. Editorial: Studying hormonal regulation by microarrays: Distinguishing the trees from the forest Journal of Clinical Endocrinology and Metabolism. 90: 1241-1242. PMID 15699542 DOI: 10.1210/jc.2004-2463  1
2005 Liu Y, Ando S, Xia X, Yao R, Kim M, Fondell J, Yen PM. p62, A TFIIH subunit, directly interacts with thyroid hormone receptor and enhances T3-mediated transcription. Molecular Endocrinology (Baltimore, Md.). 19: 879-84. PMID 15625236 DOI: 10.1210/me.2004-0385  0.01
2004 Jimenez C, Moran SA, Sereti I, Wynne S, Yen PM, Falloon J, Davey RT, Sarlis NJ. Graves' disease after interleukin-2 therapy in a patient with human immunodeficiency virus infection. Thyroid : Official Journal of the American Thyroid Association. 14: 1097-102. PMID 15650365 DOI: 10.1089/thy.2004.14.1097  1
2004 Maruvada P, Dmitrieva NI, East-Palmer J, Yen PM. Cell cycle-dependent expression of thyroid hormone receptor-beta is a mechanism for variable hormone sensitivity. Molecular Biology of the Cell. 15: 1895-903. PMID 14767065 DOI: 10.1091/mbc.e03-09-0636  0.01
2003 Yen PM. Molecular basis of resistance to thyroid hormone Trends in Endocrinology and Metabolism. 14: 327-333. PMID 12946875 DOI: 10.1016/S1043-2760(03)00114-0  1
2003 Yen PM, Feng X, Flamant F, Chen Y, Walker RL, Weiss RE, Chassande O, Samarut J, Refetoff S, Meltzer PS. Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice. Embo Reports. 4: 581-7. PMID 12776178 DOI: 10.1038/Sj.Embor.Embor862  0.01
2003 Poguet AL, Legrand C, Feng X, Yen PM, Meltzer P, Samarut J, Flamant F. Microarray analysis of knockout mice identifies cyclin D2 as a possible mediator for the action of thyroid hormone during the postnatal development of the cerebellum. Developmental Biology. 254: 188-99. PMID 12591240 DOI: 10.1016/S0012-1606(02)00039-8  0.01
2003 Maruvada P, Baumann CT, Hager GL, Yen PM. Dynamic shuttling and intranuclear mobility of nuclear hormone receptors. The Journal of Biological Chemistry. 278: 12425-32. PMID 12506123 DOI: 10.1074/Jbc.M202752200  0.01
2003 Saunier B, Triyatni M, Ulianich L, Maruvada P, Yen P, Kohn LD. Role of the asialoglycoprotein receptor in binding and entry of hepatitis C virus structural proteins in cultured human hepatocytes. Journal of Virology. 77: 546-59. PMID 12477859 DOI: 10.1128/Jvi.77.1.546-559.2003  0.01
2002 Rotman-Pikielny P, Hirschberg K, Maruvada P, Suzuki K, Royaux IE, Green ED, Kohn LD, Lippincott-Schwartz J, Yen PM. Retention of pendrin in the endoplasmic reticulum is a major mechanism for Pendred syndrome Human Molecular Genetics. 11: 2625-2633. PMID 12354788 DOI: 10.1093/Hmg/11.21.2625  1
2002 Feng X, Meltzer P, Yen PM. Transgenic targeting of a dominant negative corepressor to liver and analyses by cDNA microarray. Methods in Molecular Biology (Clifton, N.J.). 202: 31-54. PMID 12094606 DOI: 10.1385/1-59259-174-4:31  0.01
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