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Michael E. O'Donnell - Publications

Affiliations: 
1986-1996 Weill Cornell Medical College, New York, NY, United States 
 1996- Rockefeller University, New York, NY, United States 
Area:
DNA Replication
Website:
http://www.rockefeller.edu/research/faculty/labheads/MichaelDonnell/
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241 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Zheng F, Yao NY, Georgescu RE, Li H, O'Donnell ME. Structure of the PCNA unloader Elg1-RFC. Science Advances. 10: eadl1739. PMID 38427736 DOI: 10.1126/sciadv.adl1739  0.557
2024 Subramanian S, Zhang W, Nimkar S, Kamel M, O'Donnell M, Kuriyan J. Adaptive capacity of a DNA polymerase clamp-loader ATPase complex. Molecular Biology and Evolution. PMID 38298175 DOI: 10.1093/molbev/msae013  0.417
2024 Marcus K, Huang Y, Subramanian S, Gee CL, Gorday K, Ghaffari-Kashani S, Luo XR, Zheng L, O'Donnell M, Subramaniam S, Kuriyan J. Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM. Nature Structural & Molecular Biology. PMID 38177685 DOI: 10.1038/s41594-023-01177-3  0.387
2023 Langston LD, Georgescu RE, O'Donnell ME. Mechanism of eukaryotic origin unwinding is a dual helicase DNA shearing process. Proceedings of the National Academy of Sciences of the United States of America. 120: e2316466120. PMID 38109526 DOI: 10.1073/pnas.2316466120  0.548
2023 Zheng F, Georgescu RE, Yao NY, O'Donnell ME, Li H. Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification on biology. Cell Reports. 42: 112694. PMID 37392384 DOI: 10.1016/j.celrep.2023.112694  0.534
2023 Yuan Z, Georgescu R, Li H, O'Donnell ME. Molecular choreography of primer synthesis by the eukaryotic Pol α-primase. Nature Communications. 14: 3697. PMID 37344454 DOI: 10.1038/s41467-023-39441-1  0.355
2023 Zheng F, Georgescu RE, Yao NY, O'Donnell ME, Li H. Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification to biology. Biorxiv : the Preprint Server For Biology. PMID 37205533 DOI: 10.1101/2023.05.03.539266  0.52
2023 Yuan Z, Georgescu R, Li H, O'Donnell ME. Molecular choreography of primer synthesis by the eukaryotic Pol α-primase. Biorxiv : the Preprint Server For Biology. PMID 37205351 DOI: 10.1101/2023.05.03.539257  0.408
2022 Langston LD, Yuan Z, Georgescu R, Li H, O'Donnell ME. SV40 T-antigen uses a DNA shearing mechanism to initiate origin unwinding. Proceedings of the National Academy of Sciences of the United States of America. 119: e2216240119. PMID 36442086 DOI: 10.1073/pnas.2216240119  0.473
2022 Chang JT, Li S, Beckwitt EC, Than T, Haluska C, Chandanani J, O'Donnell ME, Zhao X, Liu S. Smc5/6's multifaceted DNA binding capacities stabilize branched DNA structures. Nature Communications. 13: 7179. PMID 36418314 DOI: 10.1038/s41467-022-34928-9  0.559
2022 Li S, Wasserman MR, Yurieva O, Bai L, O'Donnell ME, Liu S. Origin recognition complex harbors an intrinsic nucleosome remodeling activity. Proceedings of the National Academy of Sciences of the United States of America. 119: e2211568119. PMID 36215487 DOI: 10.1073/pnas.2211568119  0.42
2022 Li S, Wasserman MR, Yurieva O, Bai L, O'Donnell ME, Liu S. Nucleosome-directed replication origin licensing independent of a consensus DNA sequence. Nature Communications. 13: 4947. PMID 35999198 DOI: 10.1038/s41467-022-32657-7  0.478
2022 Zheng F, Georgescu RE, Yao NY, Li H, O'Donnell ME. Cryo-EM structures reveal that RFC recognizes both the 3'- and 5'-DNA ends to load PCNA onto gaps for DNA repair. Elife. 11. PMID 35829698 DOI: 10.7554/eLife.77469  0.544
2022 Zheng F, Georgescu RE, Yao NY, O'Donnell ME, Li H. DNA is loaded through the 9-1-1 DNA checkpoint clamp in the opposite direction of the PCNA clamp. Nature Structural & Molecular Biology. PMID 35314830 DOI: 10.1038/s41594-022-00742-6  0.501
2022 Yao NY, Zhang D, Yurieva O, O'Donnell ME. CMG helicase can use ATPγS to unwind DNA: Implications for the rate-limiting step in the reaction mechanism. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35042821 DOI: 10.1073/pnas.2119580119  0.512
2021 Yao NY, O'Donnell ME. The DNA Replication Machine: Structure and Dynamic Function. Sub-Cellular Biochemistry. 96: 233-258. PMID 33252731 DOI: 10.1007/978-3-030-58971-4_5  0.428
2020 Li H, Yao NY, O'Donnell ME. Anatomy of a twin DNA replication factory. Biochemical Society Transactions. PMID 33300972 DOI: 10.1042/BST20200640  0.404
2020 Zheng F, Georgescu RE, Li H, O'Donnell ME. Structure of eukaryotic DNA polymerase δ bound to the PCNA clamp while encircling DNA. Proceedings of the National Academy of Sciences of the United States of America. PMID 33203675 DOI: 10.1073/pnas.2017637117  0.559
2020 Yuan Z, Georgescu R, Schauer GD, O'Donnell ME, Li H. Structure of the polymerase ε holoenzyme and atomic model of the leading strand replisome. Nature Communications. 11: 3156. PMID 32572031 DOI: 10.1038/S41467-020-16910-5  0.602
2020 Yuan Z, Georgescu R, Bai L, Zhang D, Li H, O'Donnell ME. DNA unwinding mechanism of a eukaryotic replicative CMG helicase. Nature Communications. 11: 688. PMID 32019936 DOI: 10.1038/S41467-020-14577-6  0.441
2019 Lewis JS, Spenkelink LM, Schauer GD, Yurieva O, Mueller SH, Natarajan V, Kaur G, Maher C, Kay C, O'Donnell ME, van Oijen AM. Tunability of DNA Polymerase Stability during Eukaryotic DNA Replication. Molecular Cell. PMID 31704183 DOI: 10.1016/J.Molcel.2019.10.005  0.534
2019 Yuan Z, Georgescu R, Santos RLA, Zhang D, Bai L, Yao NY, Zhao G, O'Donnell ME, Li H. Ctf4 organizes sister replisomes and Pol α into a replication factory. Elife. 8. PMID 31589141 DOI: 10.7554/Elife.47405  0.367
2019 Yao NY, O'Donnell ME. Getting ready for DNA duplication. Elife. 8. PMID 31560343 DOI: 10.7554/Elife.51291  0.594
2019 Whinn KS, Kaur G, Lewis JS, Schauer GD, Mueller SH, Jergic S, Maynard H, Gan ZY, Naganbabu M, Bruchez MP, O'Donnell ME, Dixon NE, van Oijen AM, Ghodke H. Nuclease dead Cas9 is a programmable roadblock for DNA replication. Scientific Reports. 9: 13292. PMID 31527759 DOI: 10.1038/S41598-019-49837-Z  0.712
2019 Wasserman MR, Schauer GD, O'Donnell ME, Liu S. Replication Fork Activation Is Enabled by a Single-Stranded DNA Gate in CMG Helicase. Cell. 178: 600-611.e16. PMID 31348887 DOI: 10.1016/J.Bpj.2019.11.2143  0.589
2019 Langston LD, O'Donnell ME. An explanation for origin unwinding in eukaryotes. Elife. 8. PMID 31282859 DOI: 10.7554/Elife.46515  0.585
2019 Knegtel RMA, Charrier JD, Durrant SJ, Davis C, O'Donnell M, Storck P, MacCormick S, Kay D, Pinder J, Virani A, Twin H, Griffiths M, Reaper P, Littlewood P, Young S, et al. Rational design of 5-(4-(isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine (VX-970, M6620): Optimization of intra- and inter-molecular polar interactions of a new ataxia telangiectasia mutated and Rad3-related (ATR) kinase inhibitor. Journal of Medicinal Chemistry. PMID 31074988 DOI: 10.1021/acs.jmedchem.9b00426  0.354
2019 Li H, O'Donnell ME. DNA replication from two different worlds. Science (New York, N.Y.). 363: 814-815. PMID 30792289 DOI: 10.1126/Science.Aaw6265  0.587
2019 Li H, O'Donnell ME. Mathematical description of eukaryotic chromosome replication. Proceedings of the National Academy of Sciences of the United States of America. PMID 30782813 DOI: 10.1073/Pnas.1900968116  0.382
2019 Wasserman MR, Schauer GD, O'Donnell ME, Liu S. Replisome Preservation by a Single-Stranded DNA Gate in the CMG Helicase Biophysical Journal. 116: 76a. DOI: 10.1016/J.Bpj.2018.11.450  0.596
2018 Mayle R, Langston L, Molloy KR, Zhang D, Chait BT, O'Donnell ME. Mcm10 has potent strand-annealing activity and limits translocase-mediated fork regression. Proceedings of the National Academy of Sciences of the United States of America. PMID 30598452 DOI: 10.1073/Pnas.1819107116  0.537
2018 Li H, O'Donnell ME. The Eukaryotic CMG Helicase at the Replication Fork: Emerging Architecture Reveals an Unexpected Mechanism. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. PMID 29405332 DOI: 10.1002/Bies.201700208  0.606
2018 O'Donnell ME, Li H. The ring-shaped hexameric helicases that function at DNA replication forks. Nature Structural & Molecular Biology. PMID 29379175 DOI: 10.1038/S41594-018-0024-X  0.468
2017 Bai L, Yuan Z, Sun J, Georgescu R, O'Donnell ME, Li H. Architecture of the Saccharomyces cerevisiae Replisome. Advances in Experimental Medicine and Biology. 1042: 207-228. PMID 29357060 DOI: 10.1007/978-981-10-6955-0_10  0.357
2017 Schroeder JW, Randall JR, Hirst WG, O'Donnell ME, Simmons LA. Mutagenic cost of ribonucleotides in bacterial DNA. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078353 DOI: 10.1073/pnas.1710995114  0.4
2017 Lewis JS, Spenkelink LM, Schauer GD, Hill FR, Georgescu RE, O'Donnell ME, van Oijen AM. Single-molecule visualization of Saccharomyces cerevisiae leading-strand synthesis reveals dynamic interaction between MTC and the replisome. Proceedings of the National Academy of Sciences of the United States of America. PMID 28923950 DOI: 10.1073/Pnas.1711291114  0.419
2017 Langston LD, Mayle R, Schauer GD, Yurieva O, Zhang D, Yao NY, Georgescu RE, O'Donnell ME. Mcm10 promotes rapid isomerization of CMG-DNA for replisome bypass of lagging strand DNA blocks. Elife. 6. PMID 28869037 DOI: 10.7554/Elife.29118  0.637
2017 Langston LD, O'Donnell ME. Action of CMG with strand-specific DNA blocks supports an internal unwinding mode for the eukaryotic replicative helicase. Elife. 6. PMID 28346143 DOI: 10.7554/Elife.23449  0.62
2017 Georgescu R, Yuan Z, Bai L, de Luna Almeida Santos R, Sun J, Zhang D, Yurieva O, Li H, O'Donnell ME. Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28096349 DOI: 10.1073/Pnas.1620500114  0.378
2017 Schauer GD, O'Donnell ME. Quality control mechanisms exclude incorrect polymerases from the eukaryotic replication fork. Proceedings of the National Academy of Sciences of the United States of America. PMID 28069954 DOI: 10.1073/pnas.1619748114  0.436
2017 Langston LD, Mayle R, Schauer GD, Yurieva O, Zhang D, Yao NY, Georgescu RE, O'Donnell ME. Author response: Mcm10 promotes rapid isomerization of CMG-DNA for replisome bypass of lagging strand DNA blocks Elife. DOI: 10.7554/Elife.29118.020  0.587
2016 Yurieva O, O'Donnell M. Reconstitution of a eukaryotic replisome reveals the mechanism of asymmetric distribution of DNA polymerases. Nucleus (Austin, Tex.). 0. PMID 27416113 DOI: 10.1080/19491034.2016.1205774  0.585
2016 Sun J, Yuan Z, Georgescu R, Li H, O'Donnell M. The eukaryotic CMG helicase pumpjack and integration into the replisome. Nucleus (Austin, Tex.). 7: 146-154. PMID 27310307 DOI: 10.1080/19491034.2016.1174800  0.593
2016 Bastia D, Srivastava P, Zaman S, Choudhury M, Mohanty BK, Bacal J, Langston LD, Pasero P, O'Donnell ME. Phosphorylation of CMG helicase and Tof1 is required for programmed fork arrest. Proceedings of the National Academy of Sciences of the United States of America. PMID 27298353 DOI: 10.1073/Pnas.1607552113  0.331
2016 Zhang D, O'Donnell M. The Eukaryotic Replication Machine. The Enzymes. 39: 191-229. PMID 27241931 DOI: 10.1016/Bs.Enz.2016.03.004  0.563
2016 Yuan Z, Bai L, Sun J, Georgescu R, Liu J, O'Donnell ME, Li H. Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation. Nature Structural & Molecular Biology. PMID 26854665 DOI: 10.1038/Nsmb.3170  0.443
2015 Sun J, Shi Y, Georgescu RE, Yuan Z, Chait BT, Li H, O'Donnell ME. The architecture of a eukaryotic replisome. Nature Structural & Molecular Biology. PMID 26524492 DOI: 10.1038/Nsmb.3113  0.607
2015 Georgescu RE, Schauer GD, Yao NY, Langston LD, Yurieva O, Zhang D, Finkelstein J, O'Donnell ME. Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation. Elife. 4: e04988. PMID 25871847 DOI: 10.7554/Elife.04988  0.47
2015 Georgescu R, Langston L, O'Donnell M. A proposal: Evolution of PCNA's role as a marker of newly replicated DNA. Dna Repair. 29: 4-15. PMID 25704660 DOI: 10.1016/J.Dnarep.2015.01.015  0.52
2014 Langston LD, Zhang D, Yurieva O, Georgescu RE, Finkelstein J, Yao NY, Indiani C, O'Donnell ME. CMG helicase and DNA polymerase ε form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication. Proceedings of the National Academy of Sciences of the United States of America. 111: 15390-5. PMID 25313033 DOI: 10.1073/Pnas.1418334111  0.555
2014 Georgescu RE, Langston L, Yao NY, Yurieva O, Zhang D, Finkelstein J, Agarwal T, O'Donnell ME. Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork. Nature Structural & Molecular Biology. 21: 664-70. PMID 24997598 DOI: 10.1038/Nsmb.2851  0.55
2014 Georgescu RE, Yao N, Indiani C, Yurieva O, O'Donnell ME. Replisome mechanics: lagging strand events that influence speed and processivity. Nucleic Acids Research. 42: 6497-510. PMID 24829446 DOI: 10.1093/Nar/Gku257  0.555
2014 Marzahn MR, Hayner JN, Finkelstein J, O'Donnell M, Bloom LB. The ATP sites of AAA+ clamp loaders work together as a switch to assemble clamps on DNA. The Journal of Biological Chemistry. 289: 5537-48. PMID 24436332 DOI: 10.1074/Jbc.M113.541466  0.492
2013 Chiraniya A, Finkelstein J, O'Donnell M, Bloom LB. A novel function for the conserved glutamate residue in the walker B motif of replication factor C. Genes. 4: 134-51. PMID 23946885 DOI: 10.3390/Genes4020134  0.495
2013 Pomerantz RT, Goodman MF, O'Donnell ME. DNA polymerases are error-prone at RecA-mediated recombination intermediates. Cell Cycle (Georgetown, Tex.). 12: 2558-63. PMID 23907132 DOI: 10.4161/Cc.25691  0.464
2013 Yao NY, Schroeder JW, Yurieva O, Simmons LA, O'Donnell ME. Cost of rNTP/dNTP pool imbalance at the replication fork. Proceedings of the National Academy of Sciences of the United States of America. 110: 12942-7. PMID 23882084 DOI: 10.1073/pnas.1309506110  0.432
2013 O'Donnell M, Langston L, Stillman B. Principles and concepts of DNA replication in bacteria, archaea, and eukarya Cold Spring Harbor Perspectives in Biology. 5. PMID 23818497 DOI: 10.1101/Cshperspect.A010108  0.456
2013 Pomerantz RT, Kurth I, Goodman MF, O'Donnell ME. Preferential D-loop extension by a translesion DNA polymerase underlies error-prone recombination. Nature Structural & Molecular Biology. 20: 748-55. PMID 23686288 DOI: 10.1038/Nsmb.2573  0.403
2013 Kurth I, Georgescu RE, O'Donnell ME. A solution to release twisted DNA during chromosome replication by coupled DNA polymerases. Nature. 496: 119-22. PMID 23535600 DOI: 10.1038/Nature11988  0.609
2013 Indiani C, Patel M, Goodman MF, O'Donnell ME. RecA acts as a switch to regulate polymerase occupancy in a moving replication fork. Proceedings of the National Academy of Sciences of the United States of America. 110: 5410-5. PMID 23509251 DOI: 10.1073/pnas.1303301110  0.458
2013 Indiani C, O'Donnell M. A proposal: Source of single strand DNA that elicits the SOS response. Frontiers in Bioscience (Landmark Edition). 18: 312-23. PMID 23276924 DOI: 10.2741/4102  0.533
2013 Kurth I, O'Donnell M. New insights into replisome fluidity during chromosome replication. Trends in Biochemical Sciences. 38: 195-203. PMID 23153958 DOI: 10.1016/j.tibs.2012.10.003  0.331
2012 Yao NY, O'Donnell M. The RFC clamp loader: structure and function. Sub-Cellular Biochemistry. 62: 259-79. PMID 22918590 DOI: 10.1007/978-94-007-4572-8_14  0.503
2012 Langston LD, O'Donnell M. Subunit sharing among high- and low-fidelity DNA polymerases. Proceedings of the National Academy of Sciences of the United States of America. 109: 12268-9. PMID 22826240 DOI: 10.1073/Pnas.1209533109  0.493
2012 Kelch BA, Makino DL, O'Donnell M, Kuriyan J. Clamp loader ATPases and the evolution of DNA replication machinery Bmc Biology. 10. PMID 22520345 DOI: 10.1186/1741-7007-10-34  0.612
2012 Sakato M, O'Donnell M, Hingorani MM. A central swivel point in the RFC clamp loader controls PCNA opening and loading on DNA. Journal of Molecular Biology. 416: 163-75. PMID 22197374 DOI: 10.1016/J.Jmb.2011.12.017  0.712
2012 Georgescu RE, Kurth I, O'Donnell ME. Single-molecule studies reveal the function of a third polymerase in the replisome. Nature Structural & Molecular Biology. 19: 113-6. PMID 22157955 DOI: 10.1038/Nsmb.2179  0.518
2012 Thompson JA, Marzahn MR, O'Donnell M, Bloom LB. Replication factor C is a more effective proliferating cell nuclear antigen (PCNA) opener than the checkpoint clamp loader, Rad24-RFC. The Journal of Biological Chemistry. 287: 2203-9. PMID 22115746 DOI: 10.1074/Jbc.C111.318899  0.596
2012 Kelch B, Makino D, Simonetta K, O'Donnell M, Kuriyan J. Molecular mechanisms of DNA polymerase clamp loaders Nato Science For Peace and Security Series a: Chemistry and Biology. 103-114. DOI: 10.1007/978-94-007-2530-0_10  0.468
2011 Paschall CO, Thompson JA, Marzahn MR, Chiraniya A, Hayner JN, O'Donnell M, Robbins AH, McKenna R, Bloom LB. The Escherichia coli clamp loader can actively pry open the β-sliding clamp. The Journal of Biological Chemistry. 286: 42704-14. PMID 21971175 DOI: 10.1074/Jbc.M111.268169  0.582
2011 Charrier JD, Durrant SJ, Golec JM, Kay DP, Knegtel RM, MacCormick S, Mortimore M, O'Donnell ME, Pinder JL, Reaper PM, Rutherford AP, Wang PS, Young SC, Pollard JR. Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. Journal of Medicinal Chemistry. 54: 2320-30. PMID 21413798 DOI: 10.1021/jm101488z  0.328
2011 Kelch BA, Makino DL, O'Donnell M, Kuriyan J. How a DNA polymerase clamp loader opens a sliding clamp Science. 334: 1675-1680. DOI: 10.1126/science.1211884  0.532
2010 Yao NY, O'Donnell M. SnapShot: The replisome. Cell. 141: 1088, 1088.e1. PMID 20550941 DOI: 10.1016/J.Cell.2010.05.042  0.613
2010 Pomerantz RT, O'Donnell M. Direct restart of a replication fork stalled by a head-on RNA polymerase. Journal of Visualized Experiments : Jove. PMID 20436399 DOI: 10.3791/1919  0.435
2010 Georgescu RE, Yao NY, O'Donnell M. Single-molecule analysis of the Escherichia coli replisome and use of clamps to bypass replication barriers. Febs Letters. 584: 2596-605. PMID 20388515 DOI: 10.1016/J.Febslet.2010.04.003  0.543
2010 Park AY, Jergic S, Politis A, Ruotolo BT, Hirshberg D, Jessop LL, Beck JL, Barsky D, O'Donnell M, Dixon NE, Robinson CV. A single subunit directs the assembly of the Escherichia coli DNA sliding clamp loader. Structure (London, England : 1993). 18: 285-92. PMID 20223211 DOI: 10.1016/J.Str.2010.01.009  0.708
2010 McNally R, Bowman GD, Goedken ER, O'Donnell M, Kuriyan J. Analysis of the role of PCNA-DNA contacts during clamp loading. Bmc Structural Biology. 10: 3. PMID 20113510 DOI: 10.1186/1472-6807-10-3  0.644
2010 Pomerantz RT, O'Donnell M. Direct restart of a replication fork stalled by a head-on RNA polymerase. Science (New York, N.Y.). 327: 590-2. PMID 20110508 DOI: 10.1126/science.1179595  0.322
2009 Kurth I, O'Donnell M. Replisome Dynamics during Chromosome Duplication. Ecosal Plus. 3. PMID 26443767 DOI: 10.1128/ecosalplus.4.4.2  0.483
2009 Pluciennik A, Burdett V, Lukianova O, O'Donnell M, Modrich P. Involvement of the beta clamp in methyl-directed mismatch repair in vitro. The Journal of Biological Chemistry. 284: 32782-91. PMID 19783657 DOI: 10.1074/Jbc.M109.054528  0.754
2009 Park MS, O'Donnell M. The clamp loader assembles the beta clamp onto either a 3' or 5' primer terminus: the underlying basis favoring 3' loading. The Journal of Biological Chemistry. 284: 31473-83. PMID 19759020 DOI: 10.1074/jbc.M109.050310  0.395
2009 Thompson JA, Paschall CO, O'Donnell M, Bloom LB. A slow ATP-induced conformational change limits the rate of DNA binding but not the rate of beta clamp binding by the escherichia coli gamma complex clamp loader. The Journal of Biological Chemistry. 284: 32147-57. PMID 19759003 DOI: 10.1074/jbc.M109.045997  0.542
2009 Georgescu RE, Kurth I, Yao NY, Stewart J, Yurieva O, O'Donnell M. Mechanism of polymerase collision release from sliding clamps on the lagging strand. The Embo Journal. 28: 2981-91. PMID 19696739 DOI: 10.1038/Emboj.2009.233  0.593
2009 Yao NY, Georgescu RE, Finkelstein J, O'Donnell ME. Single-molecule analysis reveals that the lagging strand increases replisome processivity but slows replication fork progression. Proceedings of the National Academy of Sciences of the United States of America. 106: 13236-41. PMID 19666586 DOI: 10.1073/Pnas.0906157106  0.542
2009 Anderson SG, Thompson JA, Paschall CO, O'Donnell M, Bloom LB. Temporal correlation of DNA binding, ATP hydrolysis, and clamp release in the clamp loading reaction catalyzed by the Escherichia coli gamma complex. Biochemistry. 48: 8516-27. PMID 19663416 DOI: 10.1021/bi900912a  0.519
2009 Langston LD, Indiani C, O'Donnell M. Whither the replisome: emerging perspectives on the dynamic nature of the DNA replication machinery. Cell Cycle (Georgetown, Tex.). 8: 2686-91. PMID 19652539 DOI: 10.4161/Cc.8.17.9390  0.542
2009 Simonetta KR, Kazmirski SL, Goedken ER, Cantor AJ, Kelch BA, McNally R, Seyedin SN, Makino DL, O'Donnell M, Kuriyan J. The mechanism of ATP-dependent primer-template recognition by a clamp loader complex. Cell. 137: 659-71. PMID 19450514 DOI: 10.1016/J.Cell.2009.03.044  0.642
2009 Yao NY, O'Donnell M. Replisome structure and conformational dynamics underlie fork progression past obstacles. Current Opinion in Cell Biology. 21: 336-43. PMID 19375905 DOI: 10.1016/j.ceb.2009.02.008  0.453
2009 Indiani C, Langston LD, Yurieva O, Goodman MF, O'Donnell M. Translesion DNA polymerases remodel the replisome and alter the speed of the replicative helicase. Proceedings of the National Academy of Sciences of the United States of America. 106: 6031-8. PMID 19279203 DOI: 10.1073/Pnas.0901403106  0.565
2009 O'Donnell M. Replisome Dynamics And Polymerase Exchanges Enable Forks To Cope With Various Obsticals Biophysical Journal. 96: 553a. DOI: 10.1016/J.Bpj.2008.12.3634  0.555
2009 Barsky D, Park A, Hirschberg D, Ruotolo BT, Jergic S, Dixon NE, O'Donnell M, Robinson CV. Ion Mobility-Mass Spectrometry Measurements Combined with Molecular Modeling Yields the Architecture of DNA Polymerase Complexes Biophysical Journal. 96: 209a. DOI: 10.1016/J.Bpj.2008.12.1854  0.669
2009 Sakato M, O'Donnell M, Hingorani MM. Kinetic Analysis of Arginine-Finger Motif Function in S. cerevisiae Clamp Loader Biophysical Journal. 96: 341a. DOI: 10.1016/J.Bpj.2008.12.1711  0.759
2008 Lamers MH, O'Donnell M. A consensus view of DNA binding by the C family of replicative DNA polymerases. Proceedings of the National Academy of Sciences of the United States of America. 105: 20565-6. PMID 19106294 DOI: 10.1073/Pnas.0811279106  0.526
2008 Pomerantz RT, O'Donnell M. The replisome uses mRNA as a primer after colliding with RNA polymerase. Nature. 456: 762-6. PMID 19020502 DOI: 10.1038/nature07527  0.319
2008 Minko IG, Yamanaka K, Kozekov ID, Kozekova A, Indiani C, O'Donnell ME, Jiang Q, Goodman MF, Rizzo CJ, Lloyd RS. Replication bypass of the acrolein-mediated deoxyguanine DNA-peptide cross-links by DNA polymerases of the DinB family. Chemical Research in Toxicology. 21: 1983-90. PMID 18788757 DOI: 10.1021/Tx800174A  0.508
2008 Georgescu RE, Yurieva O, Kim SS, Kuriyan J, Kong XP, O'Donnell M. Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp Proceedings of the National Academy of Sciences of the United States of America. 105: 11116-11121. PMID 18678908 DOI: 10.1073/Pnas.0804754105  0.588
2008 Langston LD, O'Donnell M. DNA polymerase delta is highly processive with proliferating cell nuclear antigen and undergoes collision release upon completing DNA. The Journal of Biological Chemistry. 283: 29522-31. PMID 18635534 DOI: 10.1074/Jbc.M804488200  0.621
2008 Laurence TA, Kwon Y, Johnson A, Hollars CW, O'Donnell M, Camarero JA, Barsky D. Motion of a DNA sliding clamp observed by single molecule fluorescence spectroscopy. The Journal of Biological Chemistry. 283: 22895-906. PMID 18556658 DOI: 10.1074/Jbc.M800174200  0.62
2008 Chen S, Coman MM, Sakato M, O'Donnell M, Hingorani MM. Conserved residues in the δ subunit help the E. coli clamp loader, γ complex, target primer-template DNA for clamp assembly Nucleic Acids Research. 36: 3274-3286. PMID 18424802 DOI: 10.1093/Nar/Gkn157  0.824
2008 Georgescu RE, Kim SS, Yurieva O, Kuriyan J, Kong XP, O'Donnell M. Structure of a Sliding Clamp on DNA Cell. 132: 43-54. PMID 18191219 DOI: 10.1016/J.Cell.2007.11.045  0.663
2007 Kadyrov FA, Holmes SF, Arana ME, Lukianova OA, O'Donnell M, Kunkel TA, Modrich P. Saccharomyces cerevisiae MutLalpha is a mismatch repair endonuclease. The Journal of Biological Chemistry. 282: 37181-90. PMID 17951253 DOI: 10.1074/Jbc.M707617200  0.685
2007 Georgescu RE, O'Donnell M. Structural biology. Getting DNA to unwind. Science (New York, N.Y.). 317: 1181-2. PMID 17761872 DOI: 10.1126/Science.1147795  0.608
2007 McInerney P, Johnson A, Katz F, O'Donnell M. Characterization of a triple DNA polymerase replisome. Molecular Cell. 27: 527-38. PMID 17707226 DOI: 10.1016/J.Molcel.2007.06.019  0.635
2007 McInerney P, O'Donnell M. Replisome fate upon encountering a leading strand block and clearance from DNA by recombination proteins. The Journal of Biological Chemistry. 282: 25903-16. PMID 17609212 DOI: 10.1074/Jbc.M703777200  0.616
2007 Pomerantz RT, O'Donnell M. Replisome mechanics: insights into a twin DNA polymerase machine. Trends in Microbiology. 15: 156-64. PMID 17350265 DOI: 10.1016/j.tim.2007.02.007  0.488
2007 Anderson SG, Williams CR, O'donnell M, Bloom LB. A function for the psi subunit in loading the Escherichia coli DNA polymerase sliding clamp. The Journal of Biological Chemistry. 282: 7035-45. PMID 17210572 DOI: 10.1074/jbc.M610136200  0.544
2006 Johnson A, Yao NY, Bowman GD, Kuriyan J, O'Donnell M. The replication factor C clamp loader requires arginine finger sensors to drive DNA binding and proliferating cell nuclear antigen loading. The Journal of Biological Chemistry. 281: 35531-43. PMID 16980295 DOI: 10.1074/Jbc.M606090200  0.531
2006 Indiani C, O'Donnell M. The replication clamp-loading machine at work in the three domains of life. Nature Reviews. Molecular Cell Biology. 7: 751-61. PMID 16955075 DOI: 10.1038/Nrm2022  0.491
2006 O'Donnell M, Jeruzalmi D. Helical proteins initiate replication of DNA helices. Nature Structural & Molecular Biology. 13: 665-7. PMID 16886004 DOI: 10.1038/Nsmb0806-665  0.609
2006 Langston LD, O'Donnell M. DNA replication: keep moving and don't mind the gap. Molecular Cell. 23: 155-60. PMID 16857582 DOI: 10.1016/J.Molcel.2006.05.034  0.538
2006 Yao NY, Johnson A, Bowman GD, Kuriyan J, O'Donnell M. Mechanism of proliferating cell nuclear antigen clamp opening by replication factor C. The Journal of Biological Chemistry. 281: 17528-39. PMID 16608854 DOI: 10.1074/Jbc.M601273200  0.618
2006 López de Saro FJ, Marinus MG, Modrich P, O'Donnell M. The beta sliding clamp binds to multiple sites within MutL and MutS. The Journal of Biological Chemistry. 281: 14340-9. PMID 16546997 DOI: 10.1074/Jbc.M601264200  0.714
2006 O'Donnell M. Replisome architecture and dynamics in Escherichia coli. The Journal of Biological Chemistry. 281: 10653-6. PMID 16421093 DOI: 10.1074/Jbc.R500028200  0.622
2006 Argiriadi MA, Goedken ER, Bruck I, O'Donnell M, Kuriyan J. Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium. Bmc Structural Biology. 6: 2. PMID 16403212 DOI: 10.1186/1472-6807-6-2  0.607
2006 O'Donnell M, Kuriyan J. Clamp loaders and replication initiation Current Opinion in Structural Biology. 16: 35-41. PMID 16377178 DOI: 10.1016/J.Sbi.2005.12.004  0.534
2006 Kaplan DL, O'Donnell M. RuvA is a sliding collar that protects Holliday junctions from unwinding while promoting branch migration. Journal of Molecular Biology. 355: 473-90. PMID 16324713 DOI: 10.1016/J.Jmb.2005.10.075  0.565
2005 Kazmirski SL, Zhao Y, Bowman GD, O'Donnell M, Kuriyan J. Out-of-plane motions in open sliding clamps: Molecular dynamics simulations of eukaryotic and archaeal proliferating cell nuclear antigen Proceedings of the National Academy of Sciences of the United States of America. 102: 13801-13806. PMID 16169903 DOI: 10.1073/Pnas.0506430102  0.574
2005 Indiani C, McInerney P, Georgescu R, Goodman MF, O'Donnell M. A sliding-clamp toolbelt binds high- and low-fidelity DNA polymerases simultaneously. Molecular Cell. 19: 805-15. PMID 16168375 DOI: 10.1016/j.molcel.2005.08.011  0.536
2005 Johnson A, O'Donnell M. Cellular DNA replicases: components and dynamics at the replication fork. Annual Review of Biochemistry. 74: 283-315. PMID 15952889 DOI: 10.1146/Annurev.Biochem.73.011303.073859  0.606
2005 Tackett AJ, Dilworth DJ, Davey MJ, O'Donnell M, Aitchison JD, Rout MP, Chait BT. Proteomic and genomic characterization of chromatin complexes at a boundary. The Journal of Cell Biology. 169: 35-47. PMID 15824130 DOI: 10.1083/Jcb.200502104  0.324
2005 Johnson A, O'Donnell M. DNA ligase: getting a grip to seal the deal. Current Biology : Cb. 15: R90-2. PMID 15694297 DOI: 10.1016/J.Cub.2005.01.025  0.572
2005 Bowman GD, Goedken ER, Kazmirski SL, O'Donnell M, Kuriyan J. DNA polymerase clamp loaders and DNA recognition. Febs Letters. 579: 863-7. PMID 15680964 DOI: 10.1016/J.Febslet.2004.11.038  0.53
2005 Goedken ER, Kazmirski SL, Bowman GD, O'Donnell M, Kuriyan J. Mapping the interaction of DNA with the Escherichia coli DNA polymerase clamp loader complex. Nature Structural & Molecular Biology. 12: 183-90. PMID 15665871 DOI: 10.1038/Nsmb889  0.64
2005 Bruck I, Georgescu RE, O'Donnell M. Conserved interactions in the Staphylococcus aureus DNA PolC chromosome replication machine. The Journal of Biological Chemistry. 280: 18152-62. PMID 15647255 DOI: 10.1074/Jbc.M413595200  0.573
2004 Kazmirski SL, Podobnik M, Weitze TF, O'Donnell M, Kuriyan J. Structural analysis of the inactive state of the Escherichia coli DNA polymerase clamp-loader complex Proceedings of the National Academy of Sciences of the United States of America. 101: 16750-16755. PMID 15556993 DOI: 10.1073/Pnas.0407904101  0.456
2004 Magdalena Coman M, Jin M, Ceapa R, Finkelstein J, O'Donnell M, Chait BT, Hingorani MM. Dual functions, clamp opening and primer-template recognition, define a key clamp loader subunit. Journal of Molecular Biology. 342: 1457-69. PMID 15364574 DOI: 10.1016/J.Jmb.2004.07.097  0.812
2004 Kaplan DL, O'Donnell M. Twin DNA pumps of a hexameric helicase provide power to simultaneously melt two duplexes. Molecular Cell. 15: 453-65. PMID 15304224 DOI: 10.1016/J.Molcel.2004.06.039  0.633
2004 Bertram JG, Bloom LB, O'Donnell M, Goodman MF. Increased dNTP binding affinity reveals a nonprocessive role for Escherichia coli beta clamp with DNA polymerase IV. The Journal of Biological Chemistry. 279: 33047-50. PMID 15210708 DOI: 10.1074/jbc.C400265200  0.596
2004 Bowman GD, O'Donnell M, Kuriyan J. Structural analysis of a eukaryotic sliding DNA clamp-clamp loader complex Nature. 429: 724-730. PMID 15201901 DOI: 10.1038/Nature02585  0.649
2004 López de Saro F, Georgescu RE, Leu F, O'Donnell M. Protein trafficking on sliding clamps. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 359: 25-30. PMID 15065653 DOI: 10.1098/Rstb.2003.1361  0.843
2004 Goedken ER, Levitus M, Johnson A, Bustamante C, O'Donnell M, Kuriyan J. Fluorescence measurements on the E.coli DNA polymerase clamp loader: implications for conformational changes during ATP and clamp binding. Journal of Molecular Biology. 336: 1047-59. PMID 15037068 DOI: 10.1016/J.Jmb.2003.12.074  0.582
2004 McInerney P, O'Donnell M. Functional uncoupling of twin polymerases: mechanism of polymerase dissociation from a lagging-strand block. The Journal of Biological Chemistry. 279: 21543-51. PMID 15014081 DOI: 10.1074/Jbc.M401649200  0.625
2004 Gulbis JM, Kazmirski SL, Finkelstein J, Kelman Z, O'Donnell M, Kuriyan J. Crystal structure of the chi:psi subassembly of the Escherichia coli DNA polymerase clamp-loader complex European Journal of Biochemistry. 271: 439-449. PMID 14717711 DOI: 10.1046/J.1432-1033.2003.03944.X  0.549
2004 Snyder AK, Williams CR, Johnson A, O'Donnell M, Bloom LB. Mechanism of loading the Escherichia coli DNA polymerase III sliding clamp: II. Uncoupling the beta and DNA binding activities of the gamma complex. The Journal of Biological Chemistry. 279: 4386-93. PMID 14610068 DOI: 10.1074/jbc.M310430200  0.552
2004 Williams CR, Snyder AK, Kuzmic P, O'Donnell M, Bloom LB. Mechanism of loading the Escherichia coli DNA polymerase III sliding clamp: I. Two distinct activities for individual ATP sites in the gamma complex. The Journal of Biological Chemistry. 279: 4376-85. PMID 14610067 DOI: 10.1074/jbc.M310429200  0.569
2003 López de Saro FJ, Georgescu RE, Goodman MF, O'Donnell M. Competitive processivity-clamp usage by DNA polymerases during DNA replication and repair. The Embo Journal. 22: 6408-18. PMID 14633999 DOI: 10.1093/Emboj/Cdg603  0.671
2003 López de Saro FJ, Georgescu RE, O'Donnell M. A peptide switch regulates DNA polymerase processivity. Proceedings of the National Academy of Sciences of the United States of America. 100: 14689-94. PMID 14630952 DOI: 10.1073/Pnas.2435454100  0.645
2003 Yao N, Coryell L, Zhang D, Georgescu RE, Finkelstein J, Coman MM, Hingorani MM, O'Donnell M. Replication factor C clamp loader subunit arrangement within the circular pentamer and its attachment points to proliferating cell nuclear antigen. The Journal of Biological Chemistry. 278: 50744-53. PMID 14530260 DOI: 10.1074/Jbc.M309206200  0.807
2003 Kaplan DL, Davey MJ, O'Donnell M. Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex. The Journal of Biological Chemistry. 278: 49171-82. PMID 13679365 DOI: 10.1074/Jbc.M308074200  0.595
2003 Kaplan DL, O'Donnell M. Rho factor: transcription termination in four steps. Current Biology : Cb. 13: R714-6. PMID 13678611 DOI: 10.1016/J.Cub.2003.08.047  0.332
2003 Bruck I, Goodman MF, O'Donnell M. The essential C family DnaE polymerase is error-prone and efficient at lesion bypass. The Journal of Biological Chemistry. 278: 44361-8. PMID 12949067 DOI: 10.1074/Jbc.M308307200  0.459
2003 Davey MJ, O'Donnell M. Replicative helicase loaders: ring breakers and ring makers. Current Biology : Cb. 13: R594-6. PMID 12906810 DOI: 10.1016/S0960-9822(03)00523-2  0.505
2003 Indiani C, O'Donnell M. Mechanism of the delta wrench in opening the beta sliding clamp. The Journal of Biological Chemistry. 278: 40272-81. PMID 12851392 DOI: 10.1074/Jbc.M305828200  0.468
2003 Finkelstein J, Antony E, Hingorani MM, O'Donnell M. Overproduction and analysis of eukaryotic multiprotein complexes in Escherichia coli using a dual-vector strategy. Analytical Biochemistry. 319: 78-87. PMID 12842110 DOI: 10.1016/S0003-2697(03)00273-2  0.744
2003 Podobnik M, Weitze TF, O'Donnell M, Kuriyan J. Nucleotide-induced conformational changes in an isolated Escherichia coli DNA polymerase III clamp loader subunit. Structure (London, England : 1993). 11: 253-63. PMID 12623013 DOI: 10.1016/S0969-2126(03)00027-3  0.533
2003 Leu FP, Georgescu R, O'Donnell M. Mechanism of the E. coli tau processivity switch during lagging-strand synthesis. Molecular Cell. 11: 315-27. PMID 12620221 DOI: 10.1016/S1097-2765(03)00042-X  0.826
2003 Johnson A, O'Donnell M. Ordered ATP hydrolysis in the gamma complex clamp loader AAA+ machine. The Journal of Biological Chemistry. 278: 14406-13. PMID 12582167 DOI: 10.1074/Jbc.M212708200  0.457
2003 Ason B, Handayani R, Williams CR, Bertram JG, Hingorani MM, O'Donnell M, Goodman MF, Bloom LB. Mechanism of loading the Escherichia coli DNA polymerase III beta sliding clamp on DNA. Bona fide primer/templates preferentially trigger the gamma complex to hydrolyze ATP and load the clamp. The Journal of Biological Chemistry. 278: 10033-40. PMID 12519754 DOI: 10.1074/Jbc.M211741200  0.809
2003 Davey MJ, Indiani C, O'Donnell M. Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture. The Journal of Biological Chemistry. 278: 4491-9. PMID 12480933 DOI: 10.1074/Jbc.M210511200  0.394
2003 Davey M, O'Donnell M. DNA replication initiation Reactome - a Curated Knowledgebase of Biological Pathways. 2. DOI: 10.3180/React_2244.1  0.6
2002 Davey MJ, Jeruzalmi D, Kuriyan J, O'Donnell M. Motors and switches: AAA+ machines within the replisome. Nature Reviews. Molecular Cell Biology. 3: 826-35. PMID 12415300 DOI: 10.1038/Nrm949  0.562
2002 Kaplan DL, O'Donnell M. DnaB drives DNA branch migration and dislodges proteins while encircling two DNA strands. Molecular Cell. 10: 647-57. PMID 12408831 DOI: 10.1016/S1097-2765(02)00642-1  0.635
2002 Kobayashi S, Valentine MR, Pham P, O'Donnell M, Goodman MF. Fidelity of Escherichia coli DNA polymerase IV. Preferential generation of small deletion mutations by dNTP-stabilized misalignment. The Journal of Biological Chemistry. 277: 34198-207. PMID 12097328 DOI: 10.1074/Jbc.M204826200  0.551
2002 Jeruzalmi D, O'Donnell M, Kuriyan J. Clamp loaders and sliding clamps. Current Opinion in Structural Biology. 12: 217-24. PMID 11959500 DOI: 10.1016/S0959-440X(02)00313-5  0.501
2002 Bruck I, Yuzhakov A, Yurieva O, Jeruzalmi D, Skangalis M, Kuriyan J, O'Donnell M. Analysis of a multicomponent thermostable DNA polymerase III replicase from an extreme thermophile. The Journal of Biological Chemistry. 277: 17334-48. PMID 11859073 DOI: 10.1074/Jbc.M110198200  0.537
2002 Shen X, Sayer JM, Kroth H, Ponten I, O'Donnell M, Woodgate R, Jerina DM, Goodman MF. Efficiency and accuracy of SOS-induced DNA polymerases replicating benzo[a]pyrene-7,8-diol 9,10-epoxide A and G adducts. The Journal of Biological Chemistry. 277: 5265-74. PMID 11734560 DOI: 10.1074/Jbc.M109575200  0.468
2002 Wang Z, Lazarov E, O'Donnell M, Goodman MF. Resolving a fidelity paradox: why Escherichia coli DNA polymerase II makes more base substitution errors in AT- compared with GC-rich DNA. The Journal of Biological Chemistry. 277: 4446-54. PMID 11733526 DOI: 10.1074/Jbc.M110006200  0.586
2001 O'Donnell M, Jeruzalmi D, Kuriyan J. Clamp loader structure predicts the architecture of DNA polymerase III holoenzyme and RFC. Current Biology : Cb. 11: R935-46. PMID 11719243 DOI: 10.1016/S0960-9822(01)00559-0  0.526
2001 Leu FP, O'Donnell M. Interplay of clamp loader subunits in opening the beta sliding clamp of Escherichia coli DNA polymerase III holoenzyme. The Journal of Biological Chemistry. 276: 47185-94. PMID 11572866 DOI: 10.1074/Jbc.M106780200  0.854
2001 Jeruzalmi D, O'Donnell M, Kuriyan J. Crystal structure of the processivity clamp loader gamma (gamma) complex of E. coli DNA polymerase III. Cell. 106: 429-41. PMID 11525729 DOI: 10.1016/S0092-8674(01)00463-9  0.524
2001 Jeruzalmi D, Yurieva O, Zhao Y, Young M, Stewart J, Hingorani M, O'Donnell M, Kuriyan J. Mechanism of processivity clamp opening by the delta subunit wrench of the clamp loader complex of E. coli DNA polymerase III. Cell. 106: 417-28. PMID 11525728 DOI: 10.1016/S0092-8674(01)00462-7  0.767
2001 López de Saro FJ, O'Donnell M. Interaction of the beta sliding clamp with MutS, ligase, and DNA polymerase I. Proceedings of the National Academy of Sciences of the United States of America. 98: 8376-80. PMID 11459978 DOI: 10.1073/Pnas.121009498  0.604
2001 Zhang L, Schwartz G, O'Donnell M, Harrison RK. Development of a Novel Helicase Assay Using Electrochemiluminescence Analytical Biochemistry. 293: 31-37. PMID 11373075 DOI: 10.1006/Abio.2001.5093  0.537
2001 Stewart J, Hingorani MM, Kelman Z, O'Donnell M. Mechanism of beta clamp opening by the delta subunit of Escherichia coli DNA polymerase III holoenzyme. The Journal of Biological Chemistry. 276: 19182-9. PMID 11279099 DOI: 10.1074/Jbc.M100592200  0.729
2001 Pham P, Bertram JG, O'Donnell M, Woodgate R, Goodman MF. A model for SOS-lesion-targeted mutations in Escherichia coli. Nature. 409: 366-70. PMID 11201748 DOI: 10.1038/35053116  0.578
2001 Bruck I, O'Donnell M. The ring-type polymerase sliding clamp family. Genome Biology. 2: REVIEWS3001. PMID 11178284 DOI: 10.1186/Gb-2001-2-1-Reviews3001  0.632
2000 Hingorani MM, O'Donnell M. A tale of toroids in DNA metabolism. Nature Reviews. Molecular Cell Biology. 1: 22-30. PMID 11413486 DOI: 10.1038/35036044  0.756
2000 Davey MJ, O'Donnell M. Mechanisms of DNA replication. Current Opinion in Chemical Biology. 4: 581-586. PMID 11006548 DOI: 10.1016/S1367-5931(00)00134-4  0.544
2000 Leu FP, Hingorani MM, Turner J, O'Donnell M. The delta subunit of DNA polymerase III holoenzyme serves as a sliding clamp unloader in Escherichia coli. The Journal of Biological Chemistry. 275: 34609-18. PMID 10924523 DOI: 10.1074/Jbc.M005495200  0.858
2000 Bruck I, O'Donnell M. The DNA replication machine of a gram-positive organism. Journal of Biological Chemistry. 275: 28971-28983. PMID 10878011 DOI: 10.1074/Jbc.M003565200  0.611
2000 Bertram JG, Bloom LB, Hingorani MM, Beechem JM, O'Donnell M, Goodman MF. Molecular mechanism and energetics of clamp assembly in Escherichia coli. The role of ATP hydrolysis when gamma complex loads beta on DNA. The Journal of Biological Chemistry. 275: 28413-20. PMID 10874049 DOI: 10.1074/Jbc.M910441199  0.781
2000 Klemperer N, Zhang D, Skangalis M, O'Donnell M. Cross-utilization of the beta sliding clamp by replicative polymerases of evolutionary divergent organisms. The Journal of Biological Chemistry. 275: 26136-43. PMID 10851235 DOI: 10.1074/Jbc.M002566200  0.492
2000 Tang M, Pham P, Shen X, Taylor JS, O'Donnell M, Woodgate R, Goodman MF. Roles of E. coli DNA polymerases IV and V in lesion-targeted and untargeted SOS mutagenesis. Nature. 404: 1014-8. PMID 10801133 DOI: 10.1038/35010020  0.594
2000 Yao N, Leu FP, Anjelkovic J, Turner J, O'Donnell M. DNA structure requirements for the Escherichia coli gamma complex clamp loader and DNA polymerase III holoenzyme. The Journal of Biological Chemistry. 275: 11440-50. PMID 10753961 DOI: 10.1074/Jbc.275.15.11440  0.866
2000 Chen X, Zuo S, Kelman Z, O'Donnell M, Hurwitz J, Goodman MF. Fidelity of eucaryotic DNA polymerase δ holoenzyme from Schizosaccharomyces pombe Journal of Biological Chemistry. 275: 17677-17682. PMID 10748208 DOI: 10.1074/Jbc.M910278199  0.59
2000 Hingorani MM, O'Donnell M. Sliding clamps: a (tail)ored fit. Current Biology : Cb. 10: R25-9. PMID 10660290 DOI: 10.1016/S0960-9822(99)00252-3  0.731
2000 Ason B, Bertram JG, Hingorani MM, Beechem JM, O'Donnell M, Goodman MF, Bloom LB. A model for Escherichia coli DNA polymerase III holoenzyme assembly at primer/template ends. DNA triggers a change in binding specificity of the gamma complex clamp loader. The Journal of Biological Chemistry. 275: 3006-15. PMID 10644772 DOI: 10.1074/Jbc.275.4.3006  0.794
2000 Yao N, Hurwitz J, O'Donnell M. Dynamics of β and proliferating cell nuclear antigen sliding clamps in traversing DNA secondary structure Journal of Biological Chemistry. 275: 1421-1432. PMID 10625694 DOI: 10.1074/Jbc.275.2.1421  0.615
1999 Fang L, Davey MJ, O'Donnell M. Replisome Assembly at oriC, the Replication Origin of E. coli, Reveals an Explanation for Initiation Sites outside an Origin Molecular Cell. 4: 541-553. PMID 10549286 DOI: 10.1016/S1097-2765(00)80205-1  0.498
1999 Yuzhakov A, Kelman Z, Hurwitz J, O'Donnell M. Multiple competition reactions for RPA order the assembly of the DNA polymerase δ holoenzyme Embo Journal. 18: 6189-6199. PMID 10545128 DOI: 10.1093/Emboj/18.21.6189  0.598
1999 Hingorani MM, Bloom LB, Goodman MF, O'Donnell M. Division of labor--sequential ATP hydrolysis drives assembly of a DNA polymerase sliding clamp around DNA. The Embo Journal. 18: 5131-44. PMID 10487764 DOI: 10.1093/Emboj/18.18.5131  0.793
1999 Turner J, Hingorani MM, Kelman Z, O'Donnell M. The internal workings of a DNA polymerase clamp-loading machine Embo Journal. 18: 771-783. PMID 9927437 DOI: 10.1093/Emboj/18.3.771  0.793
1999 Dean FB, Lian L, O'Donnell M. cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster. Genomics. 54: 424-36. PMID 9878245 DOI: 10.1006/Geno.1998.5587  0.348
1998 Hingorani MM, O'Donnell M. ATP binding to the Escherichia coli clamp loader powers opening of the ring-shaped clamp of DNA polymerase III holoenzyme. The Journal of Biological Chemistry. 273: 24550-63. PMID 9733750 DOI: 10.1074/Jbc.273.38.24550  0.755
1998 Kelman Z, Yuzhakov A, Andjelkovic J, O'Donnell M. Devoted to the lagging strand - The χ subunit of DNA polymerase III holoenzyme contacts SSB to promote processive elongation and sliding clamp assembly Embo Journal. 17: 2436-2449. PMID 9545254 DOI: 10.1093/Emboj/17.8.2436  0.63
1998 Kelman Z, Hurwitz J, O'Donnell M. Processivity of DNA polymerases: Two mechanisms, one goal Structure. 6: 121-125. PMID 9519403 DOI: 10.1016/S0969-2126(98)00014-8  0.596
1998 Hingorani MM, O'Donnell M. Toroidal proteins: running rings around DNA. Current Biology : Cb. 8: R83-6. PMID 9443909 DOI: 10.1016/S0960-9822(98)70052-1  0.745
1998 Zhang D, Frappier L, Gibbs E, Hurwitz J, O'Donnell M. Human RPA (hSSB) interacts with EBNA1, the latent origin binding protein of Epstein-Barr virus. Nucleic Acids Research. 26: 631-7. PMID 9421526 DOI: 10.1093/Nar/26.2.631  0.453
1998 Ward P, Dean FB, O'Donnell ME, Berns KI. Role of the adenovirus DNA-binding protein in in vitro adeno-associated virus DNA replication. Journal of Virology. 72: 420-7. PMID 9420241 DOI: 10.1128/Jvi.72.1.420-427.1998  0.392
1997 Ishiai M, Dean FB, Okumura K, Abe M, Moon KY, Amin AA, Kagotani K, Taguchi H, Murakami Y, Hanaoka F, O'Donnell M, Hurwitz J, Eki T. Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: human homologue (ORC5L) maps to 7q22. Genomics. 46: 294-8. PMID 9417919 DOI: 10.1006/Geno.1997.5003  0.334
1997 Guenther B, Onrust R, Sali A, O'Donnell M, Kuriyan J. Crystal structure of the delta' subunit of the clamp-loader complex of E. coli DNA polymerase III. Cell. 91: 335-45. PMID 9363942 DOI: 10.1016/S0092-8674(00)80417-1  0.545
1997 Uhlmann F, Gibbs E, Cai J, O'Donnell M, Hurwitz J. Identification of regions within the four small subunits of human replication factor C required for complex formation and DNA replication. The Journal of Biological Chemistry. 272: 10065-71. PMID 9092550 DOI: 10.1074/Jbc.272.15.10065  0.564
1997 Uhlmann F, Cai J, Gibbs E, O'Donnell M, Hurwitz J. Deletion analysis of the large subunit p140 in human replication factor C reveals regions required for complex formation and replication activities. The Journal of Biological Chemistry. 272: 10058-64. PMID 9092549 DOI: 10.1074/Jbc.272.15.10058  0.552
1997 Gibbs E, Kelman Z, Gulbis JM, O'Donnell M, Kuriyan J, Burgers PM, Hurwitz J. The influence of the proliferating cell nuclear antigen-interacting domain of p21(CIP1) on DNA synthesis catalyzed by the human and Saccharomyces cerevisiae polymerase delta holoenzymes. The Journal of Biological Chemistry. 272: 2373-81. PMID 8999948 DOI: 10.1074/Jbc.272.4.2373  0.487
1997 Latham GJ, McNees AG, De Corte B, Harris CM, Harris TM, O'Donnell M, Lloyd RS. Comparison of the efficiency of synthesis past single bulky DNA adducts in vivo and in vitro by the polymerase III holoenzyme. Chemical Research in Toxicology. 9: 1167-75. PMID 8902273 DOI: 10.1021/Tx9600558  0.456
1996 Yao N, Turner J, Kelman Z, Todd Stukenberg P, Dean F, Shechter D, Pan ZQ, Hurwitz J, O'Donnell M. Clamp loading, unloading and intrinsic stability of the PCNA, β and gp45 sliding clamps of human, E. coli and T4 replicases Genes to Cells. 1: 101-113. PMID 9078370 DOI: 10.1046/J.1365-2443.1996.07007.X  0.587
1996 Bloom LB, Turner J, Kelman Z, Beechem JM, O'Donnell M, Goodman MF. Dynamics of loading the beta sliding clamp of DNA polymerase III onto DNA. The Journal of Biological Chemistry. 271: 30699-708. PMID 8940047 DOI: 10.1074/Jbc.271.48.30699  0.64
1996 Gulbis JM, Kelman Z, Hurwitz J, O'Donnell M, Kuriyan J. Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA Cell. 87: 297-306. PMID 8861913 DOI: 10.1016/S0092-8674(00)81347-1  0.492
1996 Yuzhakov A, Turner J, O'Donnell M. Replisome assembly reveals the basis for asymmetric function in leading and lagging strand replication. Cell. 86: 877-86. PMID 8808623 DOI: 10.1016/S0092-8674(00)80163-4  0.61
1996 Dean FB, O'Donnell M. Two steps to binding replication origins? DNA-protein interactions. Current Biology : Cb. 6: 931-4. PMID 8805327 DOI: 10.1016/S0960-9822(02)00629-2  0.604
1996 Paz-Elizur T, Takeshita M, Goodman M, O'Donnell M, Livneh Z. Mechanism of translesion DNA synthesis by DNA polymerase II. Comparison to DNA polymerases I and III core Journal of Biological Chemistry. 271: 24662-24669. PMID 8798733 DOI: 10.1074/Jbc.271.40.24662  0.6
1996 Uhlmann F, Cai J, Flores-Rozas H, Dean FB, Finkelstein J, O'Donnell M, Hurwitz J. In vitro reconstitution of human replication factor C from its five subunits. Proceedings of the National Academy of Sciences of the United States of America. 93: 6521-6. PMID 8692848 DOI: 10.1073/Pnas.93.13.6521  0.589
1996 Tomer G, Cohen-Fix O, O'Donnell M, Goodman M, Livneh Z. Reconstitution of repair-gap UV mutagenesis with purified proteins from Escherichia coli: A role for DNA polymerases III and II Proceedings of the National Academy of Sciences of the United States of America. 93: 1376-1380. PMID 8643639 DOI: 10.1073/Pnas.93.4.1376  0.587
1996 Turner J, O'Donnell M. Cycling of Escherichia coli DNA polymerase III from one sliding clamp to another: model for lagging strand. Methods in Enzymology. 262: 442-9. PMID 8594368 DOI: 10.1016/0076-6879(95)62035-4  0.533
1996 Naktinis V, Turner J, O'Donnell M. A molecular switch in a replication machine defined by an internal competition for protein rings. Cell. 84: 137-45. PMID 8548818 DOI: 10.1016/S0092-8674(00)81000-4  0.624
1996 Fu TJ, Sanders GM, O'Donnell M, Geiduschek EP. Dynamics of DNA-tracking by two sliding-clamp proteins. The Embo Journal. 15: 4414-4422. DOI: 10.1002/J.1460-2075.1996.Tb00814.X  0.587
1995 Kelman Z, Finkelstein J, O'Donnell M. Protein Structure: Why have six-fold symmetry? Current Biology. 5: 1239-1242. PMID 8574578 DOI: 10.1016/S0960-9822(95)00247-8  0.496
1995 Stukenberg PT, O'Donnell M. Assembly of a chromosomal replication machine: two DNA polymerases, a clamp loader, and sliding clamps in one holoenzyme particle. V. Four different polymerase-clamp complexes on DNA. The Journal of Biological Chemistry. 270: 13384-91. PMID 7768940 DOI: 10.1074/jbc.270.22.13384  0.794
1995 Xiao H, Naktinis V, O'Donnell M. Assembly of a chromosomal replication machine: two DNA polymerases, a clamp loader, and sliding clamps in one holoenzyme particle. IV. ATP-binding site mutants identify the clamp loader. The Journal of Biological Chemistry. 270: 13378-83. PMID 7768939 DOI: 10.1074/Jbc.270.22.13378  0.509
1995 Onrust R, Finkelstein J, Turner J, Naktinis V, O'Donnell M. Assembly of a chromosomal replication machine: two DNA polymerases, a clamp loader, and sliding clamps in one holoenzyme particle. III. Interface between two polymerases and the clamp loader. The Journal of Biological Chemistry. 270: 13366-77. PMID 7768938 DOI: 10.1074/Jbc.270.22.13366  0.576
1995 Onrust R, Finkelstein J, Naktinis V, Turner J, Fang L, O'Donnell M. Assembly of a chromosomal replication machine: two DNA polymerases, a clamp loader, and sliding clamps in one holoenzyme particle. I. Organization of the clamp loader. The Journal of Biological Chemistry. 270: 13348-57. PMID 7768936 DOI: 10.1074/Jbc.270.22.13348  0.635
1995 Kelman Z, O'Donnell M. Embryonic PCNA: a missing link? Current Biology. 5: 814. PMID 7583129 DOI: 10.1016/S0960-9822(95)00159-X  0.568
1995 Kelman Z, O'Donnell M. DNA polymerase III holoenzyme: Structure and function of a chromosomal replicating machine Annual Review of Biochemistry. 64: 171-200. PMID 7574479 DOI: 10.1146/Annurev.Bi.64.070195.001131  0.6
1995 Kelman Z, O'donnell M. Structural and functional similarities of prokaryotic and eukaryotic DNA polymerase sliding clamps Nucleic Acids Research. 23: 3613-3620. PMID 7478986 DOI: 10.1093/Nar/23.18.3613  0.54
1995 Naktinis V, Onrust R, Fang L, O'Donnell M. Assembly of a Chromosomal Replication Machine: Two DNA Polymerases, a Clamp Loader, and Sliding Clamps in One Holoenzyme Particle. II. INTERMEDIATE COMPLEX BETWEEN THE CLAMP LOADER AND ITS CLAMP Journal of Biological Chemistry. 270: 13358-13365. DOI: 10.1074/Jbc.270.22.13358  0.497
1994 O'Donnell M. β Sliding clamp dynamics within E. Coli DNA polymerase III holoenzyme Annals of the New York Academy of Sciences. 726: 144-155. PMID 8092672 DOI: 10.1111/J.1749-6632.1994.Tb52806.X  0.471
1994 Stukenberg PT, Turner J, O'Donnell M. An explanation for lagging strand replication: polymerase hopping among DNA sliding clamps. Cell. 78: 877-87. PMID 8087854 DOI: 10.1016/S0092-8674(94)90662-9  0.806
1994 Kelman Z, O'Donnell M. DNA replication: enzymology and mechanisms Current Opinion in Genetics and Development. 4: 185-195. PMID 8032195 DOI: 10.1016/S0959-437X(05)80044-9  0.446
1994 Flores-Rozas H, Kelman Z, Dean FB, Pan ZQ, Harper JW, Elledge SJ, O'Donnell M, Hurwitz J. Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase δ holoenzyme Proceedings of the National Academy of Sciences of the United States of America. 91: 8655-8659. PMID 7915843 DOI: 10.1073/Pnas.91.18.8655  0.594
1993 O'Donnell M, Onrust R, Dean FB, Chen M, Hurwitz J. Homology in accessory proteins of replicative polymerases--E. coli to humans. Nucleic Acids Research. 21: 1-3. PMID 8441605 DOI: 10.1093/Nar/21.1.1  0.363
1993 Blinkova A, Hervas C, Stukenberg PT, Onrust R, O'Donnell ME, Walker JR. The Escherichia coli DNA polymerase III holoenzyme contains both products of the dnaX gene, tau and gamma, but only tau is essential. Journal of Bacteriology. 175: 6018-27. PMID 8376347 DOI: 10.1128/Jb.175.18.6018-6027.1993  0.671
1993 Kuriyan J, O'Donnell M. Sliding clamps of DNA polymerases Journal of Molecular Biology. 234: 915-925. PMID 7903401 DOI: 10.1006/Jmbi.1993.1644  0.642
1992 O'Donnell M. Accessory protein function in the DNA polymerase III holoenzyme from E. coli Bioessays. 14: 105-111. PMID 1575709 DOI: 10.1002/Bies.950140206  0.552
1992 Bonner CA, Stukenberg PT, Rajagopalan M, Eritja R, O'Donnell M, McEntee K, Echols H, Goodman MF. Processive DNA synthesis by DNA polymerase II mediated by DNA polymerase III accessory proteins. The Journal of Biological Chemistry. 267: 11431-8. PMID 1534562  0.739
1992 Rajagopalan M, Lu C, Woodgate R, O'Donnell M, Goodman MF, Echols H. Activity of the purified mutagenesis proteins UmuC, UmuD', and RecA in replicative bypass of an abasic DNA lesion by DNA polymerase III. Proceedings of the National Academy of Sciences of the United States of America. 89: 10777-81. PMID 1438275 DOI: 10.1073/Pnas.89.22.10777  0.59
1992 O'Donnell M, Kuriyan J, Kong XP, Stukenberg PT, Onrust R. The sliding clamp of DNA polymerase III holoenzyme encircles DNA Molecular Biology of the Cell. 3: 953-957. PMID 1358275 DOI: 10.1091/Mbc.3.9.953  0.777
1992 Kong XP, Onrust R, O'Donnell M, Kuriyan J. Three-dimensional structure of the β subunit of E. coli DNA polymerase III holoenzyme: A sliding DNA clamp Cell. 69: 425-437. PMID 1349852 DOI: 10.1016/0092-8674(92)90445-I  0.627
1992 Frappier L, O'Donnell M. EBNA1 distorts oriP, the Epstein-Barr virus latent replication origin Journal of Virology. 66: 1786-1790. PMID 1310782 DOI: 10.1128/Jvi.66.3.1786-1790.1992  0.354
1991 Stukenberg PT, Studwell-Vaughan PS, O'Donnell M. Mechanism of the sliding beta-clamp of DNA polymerase III holoenzyme. The Journal of Biological Chemistry. 266: 11328-34. PMID 2040637  0.754
1991 Frappier L, O'Donnell M. Epstein-Barr nuclear antigen 1 mediates a DNA loop within the latent replication origin of Epstein-Barr virus Proceedings of the National Academy of Sciences of the United States of America. 88: 10875-10879. PMID 1660154 DOI: 10.1073/Pnas.88.23.10875  0.555
1991 Onrust R, Stukenberg PT, O'Donnell M. Analysis of the ATPase subassembly which initiates processive DNA synthesis by DNA polymerase III holoenzyme. The Journal of Biological Chemistry. 266: 21681-6. PMID 1657977  0.794
1987 O'Donnell ME, Elias P, Funnell BE, Lehman IR. Interaction between the DNA polymerase and single-stranded DNA-binding protein (infected cell protein 8) of herpes simplex virus 1. The Journal of Biological Chemistry. 262: 4260-6. PMID 3031068  0.794
1987 O'Donnell ME, Elias P, Lehman IR. Processive replication of single-stranded DNA templates by the herpes simplex virus-induced DNA polymerase. The Journal of Biological Chemistry. 262: 4252-9. PMID 3031067  0.801
1986 Elias P, O'Donnell ME, Mocarski ES, Lehman IR. A DNA binding protein specific for an origin of replication of herpes simplex virus type 1. Proceedings of the National Academy of Sciences of the United States of America. 83: 6322-6. PMID 3018724 DOI: 10.1073/Pnas.83.17.6322  0.754
1985 O'Donnell ME, Williams CH. Reaction of both active site thiols of reduced thioredoxin reductase with N-ethylmaleimide. Biochemistry. 24: 7617-21. PMID 3912005 DOI: 10.1021/Bi00347A018  0.486
1985 O'Donnell ME, Kornberg A. Complete replication of templates by Escherichia coli DNA polymerase III holoenzyme. The Journal of Biological Chemistry. 260: 12884-9. PMID 2413036  0.753
1985 O'Donnell ME, Kornberg A. Dynamics of DNA polymerase III holoenzyme of Escherichia coli in replication of a multiprimed template. The Journal of Biological Chemistry. 260: 12875-83. PMID 2413035  0.749
1984 O'Donnell ME, Williams CH. Graphical analysis of interactions between oxidation-reduction sites in two site oxidation-reduction proteins. Analytical Biochemistry. 136: 235-46. PMID 6370035 DOI: 10.1016/0003-2697(84)90330-0  0.416
1984 O'Donnell ME, Williams CH. Reconstitution of Escherichia coli thioredoxin reductase with 1-deazaFAD. Evidence for 1-deazaFAD C-4a adduct formation linked to the ionization of an active site base. The Journal of Biological Chemistry. 259: 2243-51. PMID 6365906  0.392
1983 O'Donnell ME, Johnson FA, Williams CH. Proton nuclear magnetic resonance investigation of the mechanism of flavin C-4a adduct formation induced by oxidized nicotinamide adenine dinucleotide binding to monoalkylated pig heart lipoamide dehydrogenase. Biochemistry. 22: 3792-6. PMID 6688532 DOI: 10.1021/Bi00285A012  0.49
1983 O'Donnell ME, Williams CH. Proton stoichiometry in the reduction of the FAD and disulfide of Escherichia coli thioredoxin reductase. Evidence for a base at the active site. The Journal of Biological Chemistry. 258: 13795-805. PMID 6358211  0.399
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