Orr Ashenberg - Publications

Affiliations: 
Fred Hutch Cancer Research Center 

20 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Hwang WL, Jagadeesh K, Guo J, Hoffman HI, Ashenberg O, Drokhlyansky E, Van Wittenberghe N, Farhi S, Schapiro D, Rodrigues C, Ciprani D, Zollinger D, Hong TS, Aguirre A, Mino-Kenudson M, et al. Single-nucleus RNA-seq of frozen archival primary pancreatic ductal adenocarcinoma uncovers multi-compartment intratumoral heterogeneity associated with neoadjuvant treatment. Journal of Clinical Oncology. 38: 4633-4633. DOI: 10.1200/Jco.2020.38.15_Suppl.4633  0.303
2020 Cohen O, Abravanel D, Slyper M, Klughammer J, Jane-Valbuena J, Helvie K, Dellostritto L, Frangieh A, Vigneau S, Wu J, Mayorga A, Waldman J, Nguyen L, Dionne D, Ashenberg O, et al. Abstract GS6-05: A joint atlas of single-cell and bulk RNA-seq in metastatic breast cancer allows inference of oncogenic and drug-resistant transcriptional programs in malignant cells and the tumor microenvironment Cancer Research. 80. DOI: 10.1158/1538-7445.Sabcs19-Gs6-05  0.31
2019 Jerby L, Shah P, Cuoco MS, Rodman C, Su M, Melms JM, Leeson R, Kanodia A, Mei S, Lin J, Wang S, Rabasha B, Liu D, Zhang G, Margolais C, ... Ashenberg O, et al. Abstract A082: Single-cell RNA-sequencing of metastatic melanoma identifies a cancer cell-intrinsic program associated with immune checkpoint inhibitor resistance Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-A082  0.308
2019 Hwang WL, Jagadeesh KA, Ashenberg O, Drokhlyansky E, Eng G, Wittenberghe NV, Freed-Pastor W, Rodriguez C, Dionne D, Waldman J, Cuoco M, Tsankov A, Lambden C, Porter C, Schenkel J, et al. Abstract A22: Molecular subtypes and resistance programs in pancreatic ductal adenocarcinoma elucidated with single-nucleus RNA-seq Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-A22  0.308
2018 Phillips AM, Ponomarenko AI, Chen K, Ashenberg O, Miao J, McHugh SM, Butty VL, Whittaker CA, Moore CL, Bloom JD, Lin YS, Shoulders MD. Destabilized adaptive influenza variants critical for innate immune system escape are potentiated by host chaperones. Plos Biology. 16: e3000008. PMID 30222731 DOI: 10.1371/Journal.Pbio.3000008  0.517
2017 Ashenberg O, Padmakumar J, Doud MB, Bloom JD. Deep mutational scanning identifies sites in influenza nucleoprotein that affect viral inhibition by MxA. Plos Pathogens. 13: e1006288. PMID 28346537 DOI: 10.1371/Journal.Ppat.1006288  0.531
2015 Doud MB, Ashenberg O, Bloom JD. Site-Specific Amino Acid Preferences Are Mostly Conserved in Two Closely Related Protein Homologs. Molecular Biology and Evolution. 32: 2944-60. PMID 26226986 DOI: 10.1093/Molbev/Msv167  0.562
2013 Ashenberg O, Gong LI, Bloom JD. Mutational effects on stability are largely conserved during protein evolution. Proceedings of the National Academy of Sciences of the United States of America. 110: 21071-6. PMID 24324165 DOI: 10.1073/Pnas.1314781111  0.58
2013 Reinke AW, Baek J, Ashenberg O, Keating AE. Networks of bZIP protein-protein interactions diversified over a billion years of evolution. Science (New York, N.Y.). 340: 730-4. PMID 23661758 DOI: 10.1126/Science.1233465  0.571
2013 Ashenberg O, Laub MT. Using analyses of amino acid coevolution to understand protein structure and function Methods in Enzymology. 523: 191-212. PMID 23422431 DOI: 10.1016/B978-0-12-394292-0.00009-6  0.621
2013 Ashenberg O, Keating AE, Laub MT. Helix bundle loops determine whether histidine kinases autophosphorylate in cis or in trans Journal of Molecular Biology. 425: 1198-1209. PMID 23333741 DOI: 10.1016/J.Jmb.2013.01.011  0.658
2013 Reinke AW, Baek J, Ashenberg O, Keating AE. Networks of bZIP protein-protein interactions diversified over a billion years of evolution Science. 340: 730-734. DOI: 10.1126/science.1233465  0.513
2013 Ashenberg O, Gong LI, Bloom JD. Mutational effects on stability are largely conserved during protein evolution Proceedings of the National Academy of Sciences of the United States of America. 110: 21071-21076. DOI: 10.1073/pnas.1314781111  0.516
2012 Capra EJ, Perchuk BS, Ashenberg O, Seid CA, Snow HR, Skerker JM, Laub MT. Spatial tethering of kinases to their substrates relaxes evolutionary constraints on specificity Molecular Microbiology. 86: 1393-1403. PMID 23078131 DOI: 10.1111/Mmi.12064  0.626
2011 Ashenberg O, Rozen-Gagnon K, Laub MT, Keating AE. Determinants of homodimerization specificity in histidine kinases Journal of Molecular Biology. 413: 222-235. PMID 21854787 DOI: 10.1016/J.Jmb.2011.08.011  0.689
2010 Capra EJ, Perchuk BS, Lubin EA, Ashenberg O, Skerker JM, Laub MT. Systematic dissection and trajectory-scanning mutagenesis of the molecular interface that ensures specificity of two-component signaling pathways. Plos Genetics. 6: e1001220. PMID 21124821 DOI: 10.1371/Journal.Pgen.1001220  0.639
2010 Hahn S, Ashenberg O, Grigoryan G, Keating AE. Identifying and reducing error in cluster-expansion approximations of protein energies Journal of Computational Chemistry. 31: 2900-2914. PMID 20602445 DOI: 10.1002/Jcc.21585  0.66
2010 Capra EJ, Perchuk BS, Lubin EA, Ashenberg O, Skerker JM, Laub MT. Systematic dissection and trajectory-scanning mutagenesis of the molecular interface that ensures specificity of two-component signaling pathways Plos Genetics. 6. DOI: 10.1371/journal.pgen.1001220  0.524
2008 Skerker JM, Perchuk BS, Siryaporn A, Lubin EA, Ashenberg O, Goulian M, Laub MT. Rewiring the Specificity of Two-Component Signal Transduction Systems Cell. 133: 1043-1054. PMID 18555780 DOI: 10.1016/J.Cell.2008.04.040  0.622
2007 Deeds EJ, Ashenberg O, Gerardin J, Shakhnovich EI. Robust protein protein interactions in crowded cellular environments. Proceedings of the National Academy of Sciences of the United States of America. 104: 14952-7. PMID 17848524 DOI: 10.1073/Pnas.0702766104  0.344
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