Phillip Allen Sharp - Publications

Biology Massachusetts Institute of Technology, Cambridge, MA, United States 
Gene splicing

237 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Klein IA, Boija A, Afeyan LK, Hawken SW, Fan M, Dall'Agnese A, Oksuz O, Henninger JE, Shrinivas K, Sabari BR, Sagi I, Clark VE, Platt JM, Kar M, McCall PM, ... ... Sharp PA, et al. Partitioning of cancer therapeutics in nuclear condensates. Science (New York, N.Y.). 368: 1386-1392. PMID 32554597 DOI: 10.1126/science.aaz4427  0.4
2019 Shrinivas K, Sabari BR, Coffey EL, Klein IA, Boija A, Zamudio AV, Schuijers J, Hannett NM, Sharp PA, Young RA, Chakraborty AK. Enhancer Features that Drive Formation of Transcriptional Condensates. Molecular Cell. 75: 549-561.e7. PMID 31398323 DOI: 10.1016/j.molcel.2019.07.009  0.4
2019 Guo YE, Manteiga JC, Henninger JE, Sabari BR, Dall'Agnese A, Hannett NM, Spille JH, Afeyan LK, Zamudio AV, Shrinivas K, Abraham BJ, Boija A, Decker TM, Rimel JK, Fant CB, ... ... Sharp PA, et al. Pol II phosphorylation regulates a switch between transcriptional and splicing condensates. Nature. PMID 31391587 DOI: 10.1038/s41586-019-1464-0  0.4
2019 Kelly TJ, Suzuki HI, Zamudio JR, Suzuki M, Sharp PA. Sequestration of microRNA-mediated target repression by the Ago2-associated RNA-binding protein FAM120A. Rna (New York, N.Y.). 25: 1291-1297. PMID 31289130 DOI: 10.1261/rna.071621.119  0.36
2019 Grigelioniene G, Suzuki HI, Taylan F, Mirzamohammadi F, Borochowitz ZU, Ayturk UM, Tzur S, Horemuzova E, Lindstrand A, Weis MA, Grigelionis G, Hammarsjö A, Marsk E, Nordgren A, Nordenskjöld M, ... ... Sharp PA, et al. Gain-of-function mutation of microRNA-140 in human skeletal dysplasia. Nature Medicine. PMID 30804514 DOI: 10.1038/s41591-019-0353-2  0.36
2018 Gao A, Shrinivas K, Lepeudry P, Suzuki HI, Sharp PA, Chakraborty AK. Evolution of weak cooperative interactions for biological specificity. Proceedings of the National Academy of Sciences of the United States of America. PMID 30404915 DOI: 10.1073/pnas.1815912115  0.36
2018 Sabari BR, Dall'Agnese A, Boija A, Klein IA, Coffey EL, Shrinivas K, Abraham BJ, Hannett NM, Zamudio AV, Manteiga JC, Li CH, Guo YE, Day DS, Schuijers J, Vasile E, ... ... Sharp PA, et al. Coactivator condensation at super-enhancers links phase separation and gene control. Science (New York, N.Y.). PMID 29930091 DOI: 10.1126/science.aar3958  0.4
2018 Suzuki HI, Spengler RM, Grigelioniene G, Kobayashi T, Sharp PA. Deconvolution of seed and RNA-binding protein crosstalk in RNAi-based functional genomics. Nature Genetics. PMID 29662165 DOI: 10.1038/s41588-018-0104-1  0.36
2018 Wang G, Chow RD, Ye L, Guzman CD, Dai X, Dong MB, Zhang F, Sharp PA, Platt RJ, Chen S. Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR-mediated direct in vivo screening. Science Advances. 4: eaao5508. PMID 29503867 DOI: 10.1126/sciadv.aao5508  0.52
2018 Chiu AC, Suzuki HI, Wu X, Mahat DB, Kriz AJ, Sharp PA. Transcriptional Pause Sites Delineate Stable Nucleosome-Associated Premature Polyadenylation Suppressed by U1 snRNP. Molecular Cell. PMID 29398447 DOI: 10.1016/j.molcel.2018.01.006  1
2018 Murphy PA, Butty VL, Boutz PL, Begum S, Kimble AL, Sharp PA, Burge CB, Hynes RO. Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow. Elife. 7. PMID 29293084 DOI: 10.7554/eLife.29494  0.96
2017 Nissim L, Wu MR, Pery E, Binder-Nissim A, Suzuki HI, Stupp D, Wehrspaun C, Tabach Y, Sharp PA, Lu TK. Synthetic RNA-Based Immunomodulatory Gene Circuits for Cancer Immunotherapy. Cell. PMID 29056342 DOI: 10.1016/j.cell.2017.09.049  0.36
2017 Chow RD, Guzman CD, Wang G, Schmidt F, Youngblood MW, Ye L, Errami Y, Dong MB, Martinez MA, Zhang S, Renauer P, Bilguvar K, Gunel M, Sharp PA, Zhang F, et al. AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma. Nature Neuroscience. PMID 28805815 DOI: 10.1038/nn.4620  0.52
2017 Hnisz D, Shrinivas K, Young RA, Chakraborty AK, Sharp PA. A Phase Separation Model for Transcriptional Control. Cell. 169: 13-23. PMID 28340338 DOI: 10.1016/j.cell.2017.02.007  0.4
2017 Suzuki HI, Young RA, Sharp PA. Super-Enhancer-Mediated RNA Processing Revealed by Integrative MicroRNA Network Analysis. Cell. 168: 1000-1014.e15. PMID 28283057 DOI: 10.1016/j.cell.2017.02.015  0.4
2016 Zhang X, Chen MH, Wu X, Kodani A, Fan J, Doan R, Ozawa M, Ma J, Yoshida N, Reiter JF, Black DL, Kharchenko PV, Sharp PA, Walsh CA. Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. Cell. 166: 1147-1162.e15. PMID 27565344 DOI: 10.1016/j.cell.2016.07.025  1
2016 Garg S, Sharp PA. GENE EXPRESSION. Single-cell variability guided by microRNAs. Science (New York, N.Y.). 352: 1390-1. PMID 27313022 DOI: 10.1126/science.aag1097  1
2015 Gosline SJ, Gurtan AM, JnBaptiste CK, Bosson A, Milani P, Dalin S, Matthews BJ, Yap YS, Sharp PA, Fraenkel E. Elucidating MicroRNA Regulatory Networks Using Transcriptional, Post-transcriptional, and Histone Modification Measurements. Cell Reports. PMID 26748710 DOI: 10.1016/j.celrep.2015.12.031  1
2015 Sigova AA, Abraham BJ, Ji X, Molinie B, Hannett NM, Guo YE, Jangi M, Giallourakis CC, Sharp PA, Young RA. Transcription factor trapping by RNA in gene regulatory elements. Science (New York, N.Y.). PMID 26516199 DOI: 10.1126/science.aad3346  1
2015 Ran FA, Cong L, Yan WX, Scott DA, Gootenberg JS, Kriz AJ, Zetsche B, Shalem O, Wu X, Makarova KS, Koonin EV, Sharp PA, Zhang F. In vivo genome editing using Staphylococcus aureus Cas9. Nature. 520: 186-91. PMID 25830891 DOI: 10.1038/nature14299  1
2015 Lieberman J, Sharp PA. Harnessing RNA interference for therapy: the silent treatment. Jama. 313: 1207-8. PMID 25803342 DOI: 10.1001/jama.2015.1241  1
2015 Chen S, Sanjana NE, Zheng K, Shalem O, Lee K, Shi X, Scott DA, Song J, Pan JQ, Weissleder R, Lee H, Zhang F, Sharp PA. Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis. Cell. 160: 1246-60. PMID 25748654 DOI: 10.1016/j.cell.2015.02.038  1
2015 Boutz PL, Bhutkar A, Sharp PA. Detained introns are a novel, widespread class of post-transcriptionally spliced introns. Genes & Development. 29: 63-80. PMID 25561496 DOI: 10.1101/gad.247361.114  1
2014 Wu X, Kriz AJ, Sharp PA. Target specificity of the CRISPR-Cas9 system. Quantitative Biology. 2: 59-70. PMID 25722925 DOI: 10.1007/s40484-014-0030-x  1
2014 Bosson AD, Zamudio JR, Sharp PA. Endogenous miRNA and target concentrations determine susceptibility to potential ceRNA competition. Molecular Cell. 56: 347-59. PMID 25449132 DOI: 10.1016/j.molcel.2014.09.018  1
2014 Jangi M, Sharp PA. Building robust transcriptomes with master splicing factors. Cell. 159: 487-98. PMID 25417102 DOI: 10.1016/j.cell.2014.09.054  1
2014 Platt RJ, Chen S, Zhou Y, Yim MJ, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovic M, Graham DB, Jhunjhunwala S, Heidenreich M, Xavier RJ, Langer R, ... ... Sharp PA, et al. CRISPR-Cas9 knockin mice for genome editing and cancer modeling. Cell. 159: 440-55. PMID 25263330 DOI: 10.1016/j.cell.2014.09.014  1
2014 Xue W, Chen S, Yin H, Tammela T, Papagiannakopoulos T, Joshi NS, Cai W, Yang G, Bronson R, Crowley DG, Zhang F, Anderson DG, Sharp PA, Jacks T. CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature. 514: 380-4. PMID 25119044 DOI: 10.1038/nature13589  1
2014 Dimitrova N, Zamudio JR, Jong RM, Soukup D, Resnick R, Sarma K, Ward AJ, Raj A, Lee JT, Sharp PA, Jacks T. LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint. Molecular Cell. 54: 777-90. PMID 24857549 DOI: 10.1016/j.molcel.2014.04.025  1
2014 Lambert N, Robertson A, Jangi M, McGeary S, Sharp PA, Burge CB. RNA Bind-n-Seq: quantitative assessment of the sequence and structural binding specificity of RNA binding proteins. Molecular Cell. 54: 887-900. PMID 24837674 DOI: 10.1016/j.molcel.2014.04.016  1
2014 Chen S, Xue Y, Wu X, Le C, Bhutkar A, Bell EL, Zhang F, Langer R, Sharp PA. Global microRNA depletion suppresses tumor angiogenesis. Genes & Development. 28: 1054-67. PMID 24788094 DOI: 10.1101/gad.239681.114  1
2014 Wu X, Scott DA, Kriz AJ, Chiu AC, Hsu PD, Dadon DB, Cheng AW, Trevino AE, Konermann S, Chen S, Jaenisch R, Zhang F, Sharp PA. Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells. Nature Biotechnology. 32: 670-6. PMID 24752079 DOI: 10.1038/nbt.2889  1
2014 Yin H, Xue W, Chen S, Bogorad RL, Benedetti E, Grompe M, Koteliansky V, Sharp PA, Jacks T, Anderson DG. Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype. Nature Biotechnology. 32: 551-3. PMID 24681508 DOI: 10.1038/nbt.2884  1
2014 Jangi M, Boutz PL, Paul P, Sharp PA. Rbfox2 controls autoregulation in RNA-binding protein networks. Genes & Development. 28: 637-51. PMID 24637117 DOI: 10.1101/gad.235770.113  1
2014 Zamudio JR, Kelly TJ, Sharp PA. Argonaute-bound small RNAs from promoter-proximal RNA polymerase II. Cell. 156: 920-34. PMID 24581493 DOI: 10.1016/j.cell.2014.01.041  1
2014 Sharp PA, Leshner AI. Meeting global challenges. Science (New York, N.Y.). 343: 579. PMID 24503818 DOI: 10.1126/science.1250725  0.68
2014 Sharp PA, Leshner AI. Plan to transform AAAS moves full steam ahead Science. 346: 1473-1474.  0.68
2013 Wu X, Sharp PA. Divergent transcription: a driving force for new gene origination? Cell. 155: 990-6. PMID 24267885 DOI: 10.1016/j.cell.2013.10.048  1
2013 Almada AE, Wu X, Kriz AJ, Burge CB, Sharp PA. Promoter directionality is controlled by U1 snRNP and polyadenylation signals. Nature. 499: 360-3. PMID 23792564 DOI: 10.1038/nature12349  1
2013 Gurtan AM, Ravi A, Rahl PB, Bosson AD, JnBaptiste CK, Bhutkar A, Whittaker CA, Young RA, Sharp PA. Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts. Genes & Development. 27: 941-54. PMID 23630078 DOI: 10.1101/gad.215376.113  1
2013 Wilusz JE, Sharp PA. Molecular biology. A circuitous route to noncoding RNA. Science (New York, N.Y.). 340: 440-1. PMID 23620042 DOI: 10.1126/science.1238522  1
2013 Gurtan AM, Sharp PA. The role of miRNAs in regulating gene expression networks. Journal of Molecular Biology. 425: 3582-600. PMID 23500488 DOI: 10.1016/j.jmb.2013.03.007  1
2013 Sigova AA, Mullen AC, Molinie B, Gupta S, Orlando DA, Guenther MG, Almada AE, Lin C, Sharp PA, Giallourakis CC, Young RA. Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 2876-81. PMID 23382218 DOI: 10.1073/pnas.1221904110  0.96
2013 Leung AK, Sharp PA. Quantifying Argonaute proteins in and out of GW/P-bodies: implications in microRNA activities. Advances in Experimental Medicine and Biology. 768: 165-82. PMID 23224970 DOI: 10.1007/978-1-4614-5107-5_10  0.96
2013 Zhao P, Damerow MS, Stern P, Liu AH, Sweet-Cordero A, Siziopikou K, Neilson JR, Sharp PA, Cheng C. CD44 promotes Kras-dependent lung adenocarcinoma. Oncogene. 32: 5186-90. PMID 23208496 DOI: 10.1038/onc.2012.542  0.96
2012 Wilusz JE, JnBaptiste CK, Lu LY, Kuhn CD, Joshua-Tor L, Sharp PA. A triple helix stabilizes the 3' ends of long noncoding RNAs that lack poly(A) tails. Genes & Development. 26: 2392-407. PMID 23073843 DOI: 10.1101/gad.204438.112  1
2012 Ravi A, Gurtan AM, Kumar MS, Bhutkar A, Chin C, Lu V, Lees JA, Jacks T, Sharp PA. Proliferation and tumorigenesis of a murine sarcoma cell line in the absence of DICER1. Cancer Cell. 21: 848-55. PMID 22698408 DOI: 10.1016/j.ccr.2012.04.037  1
2012 Gurtan AM, Lu V, Bhutkar A, Sharp PA. In vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs. Rna (New York, N.Y.). 18: 1116-22. PMID 22546613 DOI: 10.1261/rna.032680.112  1
2012 Goldberg MS, Sharp PA. Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression. The Journal of Experimental Medicine. 209: 217-24. PMID 22271574 DOI: 10.1084/jem.20111487  1
2011 Wilusz JE, Whipple JM, Phizicky EM, Sharp PA. tRNAs marked with CCACCA are targeted for degradation. Science (New York, N.Y.). 334: 817-21. PMID 22076379 DOI: 10.1126/science.1213671  1
2011 Zheng GX, Ravi A, Gould GM, Burge CB, Sharp PA. Genome-wide impact of a recently expanded microRNA cluster in mouse. Proceedings of the National Academy of Sciences of the United States of America. 108: 15804-9. PMID 21911408 DOI: 10.1073/pnas.1112772108  1
2011 Mukherji S, Ebert MS, Zheng GX, Tsang JS, Sharp PA, van Oudenaarden A. MicroRNAs can generate thresholds in target gene expression. Nature Genetics. 43: 854-9. PMID 21857679 DOI: 10.1038/ng.905  1
2011 Medeiros LA, Dennis LM, Gill ME, Houbaviy H, Markoulaki S, Fu D, White AC, Kirak O, Sharp PA, Page DC, Jaenisch R. Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects. Proceedings of the National Academy of Sciences of the United States of America. 108: 14163-8. PMID 21844366 DOI: 10.1073/pnas.1111241108  1
2011 Sharp PA, Langer R. Research agenda. Promoting convergence in biomedical science. Science (New York, N.Y.). 333: 527. PMID 21798916 DOI: 10.1126/science.1205008  1
2011 Kirschner MW, Shapiro L, McAdams H, Almouzni G, Sharp PA, Young RA, Alon U. Fifty years after Jacob and Monod: what are the unanswered questions in molecular biology? Molecular Cell. 42: 403-4. PMID 21748867  0.4
2011 Flynn RA, Almada AE, Zamudio JR, Sharp PA. Antisense RNA polymerase II divergent transcripts are P-TEFb dependent and substrates for the RNA exosome. Proceedings of the National Academy of Sciences of the United States of America. 108: 10460-5. PMID 21670248 DOI: 10.1073/pnas.1106630108  1
2011 Meenhuis A, van Veelen PA, de Looper H, van Boxtel N, van den Berge IJ, Sun SM, Taskesen E, Stern P, de Ru AH, van Adrichem AJ, Demmers J, Jongen-Lavrencic M, Löwenberg B, Touw IP, Sharp PA, et al. MiR-17/20/93/106 promote hematopoietic cell expansion by targeting sequestosome 1-regulated pathways in mice. Blood. 118: 916-25. PMID 21628417 DOI: 10.1182/blood-2011-02-336487  1
2011 Leung AK, Vyas S, Rood JE, Bhutkar A, Sharp PA, Chang P. Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm. Molecular Cell. 42: 489-99. PMID 21596313 DOI: 10.1016/j.molcel.2011.04.015  1
2011 Zheng GX, Ravi A, Calabrese JM, Medeiros LA, Kirak O, Dennis LM, Jaenisch R, Burge CB, Sharp PA. A latent pro-survival function for the mir-290-295 cluster in mouse embryonic stem cells. Plos Genetics. 7: e1002054. PMID 21573140 DOI: 10.1371/journal.pgen.1002054  1
2011 Leung AK, Young AG, Bhutkar A, Zheng GX, Bosson AD, Nielsen CB, Sharp PA. Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs. Nature Structural & Molecular Biology. 18: 237-44. PMID 21258322 DOI: 10.1038/nsmb0911-1084a  1
2011 Goldberg MS, Xing D, Ren Y, Orsulic S, Bhatia SN, Sharp PA. Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 745-50. PMID 21187397 DOI: 10.1073/pnas.1016538108  1
2011 Grishok A, Hoersch S, Sharp PA. RNA interference and retinoblastoma-related genes are required for repression of endogenous siRNA targets in Caenorhabditis elegans (Journal of Biological Chemistry (2008) 105, 51 (20386-20391) DOI: 10.1073/pnas.0810589105) Proceedings of the National Academy of Sciences of the United States of America. 108: 14371. DOI: 10.1073/pnas.1110993108  1
2010 Creyghton MP, Cheng AW, Welstead GG, Kooistra T, Carey BW, Steine EJ, Hanna J, Lodato MA, Frampton GM, Sharp PA, Boyer LA, Young RA, Jaenisch R. Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proceedings of the National Academy of Sciences of the United States of America. 107: 21931-6. PMID 21106759 DOI: 10.1073/pnas.1016071107  1
2010 Leung AK, Sharp PA. MicroRNA functions in stress responses. Molecular Cell. 40: 205-15. PMID 20965416 DOI: 10.1016/j.molcel.2010.09.027  1
2010 Ebert MS, Sharp PA. Emerging roles for natural microRNA sponges. Current Biology : Cb. 20: R858-61. PMID 20937476 DOI: 10.1016/j.cub.2010.08.052  1
2010 Ebert MS, Sharp PA. MicroRNA sponges: progress and possibilities. Rna (New York, N.Y.). 16: 2043-50. PMID 20855538 DOI: 10.1261/rna.2414110  1
2010 Singh N, Agrawal A, Leung AK, Sharp PA, Bhatia SN. Effect of nanoparticle conjugation on gene silencing by RNA interference. Journal of the American Chemical Society. 132: 8241-3. PMID 20518524 DOI: 10.1021/ja102132e  1
2010 Rahl PB, Lin CY, Seila AC, Flynn RA, McCuine S, Burge CB, Sharp PA, Young RA. c-Myc regulates transcriptional pause release. Cell. 141: 432-45. PMID 20434984 DOI: 10.1016/j.cell.2010.03.030  1
2010 Edbauer D, Neilson JR, Foster KA, Wang CF, Seeburg DP, Batterton MN, Tada T, Dolan BM, Sharp PA, Sheng M. Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. Neuron. 65: 373-84. PMID 20159450 DOI: 10.1016/j.neuron.2010.01.005  1
2009 Agrawal A, Min DH, Singh N, Zhu H, Birjiniuk A, von Maltzahn G, Harris TJ, Xing D, Woolfenden SD, Sharp PA, Charest A, Bhatia S. Functional delivery of siRNA in mice using dendriworms. Acs Nano. 3: 2495-504. PMID 19673534 DOI: 10.1021/nn900201e  1
2009 Kleppner D, Sharp PA. Research data in the digital age. Science (New York, N.Y.). 325: 368. PMID 19628822 DOI: 10.1126/science.1178927  1
2009 Seila AC, Core LJ, Lis JT, Sharp PA. Divergent transcription: a new feature of active promoters. Cell Cycle (Georgetown, Tex.). 8: 2557-64. PMID 19597342  1
2009 Sharp PA. The centrality of RNA. Cell. 136: 577-80. PMID 19239877 DOI: 10.1016/j.cell.2009.02.007  1
2009 Fukae J, Sato S, Shiba K, Sato K, Mori H, Sharp PA, Mizuno Y, Hattori N. Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease. Febs Letters. 583: 521-5. PMID 19146857 DOI: 10.1016/j.febslet.2008.12.055  0.96
2008 Grishok A, Hoersch S, Sharp PA. RNA interference and retinoblastoma-related genes are required for repression of endogenous siRNA targets in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 105: 20386-91. PMID 19073934 DOI: 10.1073/pnas.0810589105  1
2008 Seila AC, Calabrese JM, Levine SS, Yeo GW, Rahl PB, Flynn RA, Young RA, Sharp PA. Divergent transcription from active promoters. Science (New York, N.Y.). 322: 1849-51. PMID 19056940 DOI: 10.1126/science.1162253  1
2008 Neilson JR, Sharp PA. Small RNA regulators of gene expression. Cell. 134: 899-902. PMID 18805079 DOI: 10.1016/j.cell.2008.09.006  1
2008 Stern P, Astrof S, Erkeland SJ, Schustak J, Sharp PA, Hynes RO. A system for Cre-regulated RNA interference in vivo. Proceedings of the National Academy of Sciences of the United States of America. 105: 13895-900. PMID 18779577 DOI: 10.1073/pnas.0806907105  1
2008 Marson A, Levine SS, Cole MF, Frampton GM, Brambrink T, Johnstone S, Guenther MG, Johnston WK, Wernig M, Newman J, Calabrese JM, Dennis LM, Volkert TL, Gupta S, Love J, ... ... Sharp PA, et al. Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell. 134: 521-33. PMID 18692474 DOI: 10.1016/j.cell.2008.07.020  1
2008 Sandberg R, Neilson JR, Sarma A, Sharp PA, Burge CB. Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites. Science (New York, N.Y.). 320: 1643-7. PMID 18566288 DOI: 10.1126/science.1155390  1
2008 Seila AC, Sharp PA. Small RNAs tell big stories in Whistler. Nature Cell Biology. 10: 630-3. PMID 18521067 DOI: 10.1038/ncb0608-630  1
2008 Ventura A, Young AG, Winslow MM, Lintault L, Meissner A, Erkeland SJ, Newman J, Bronson RT, Crowley D, Stone JR, Jaenisch R, Sharp PA, Jacks T. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell. 132: 875-86. PMID 18329372 DOI: 10.1016/j.cell.2008.02.019  1
2008 Kumar MS, Erkeland SJ, Pester RE, Chen CY, Ebert MS, Sharp PA, Jacks T. Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proceedings of the National Academy of Sciences of the United States of America. 105: 3903-8. PMID 18308936 DOI: 10.1073/pnas.0712321105  1
2007 Calabrese JM, Seila AC, Yeo GW, Sharp PA. RNA sequence analysis defines Dicer's role in mouse embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 18097-102. PMID 17989215 DOI: 10.1073/pnas.0709193104  1
2007 Wu H, Neilson JR, Kumar P, Manocha M, Shankar P, Sharp PA, Manjunath N. miRNA profiling of naïve, effector and memory CD8 T cells. Plos One. 2: e1020. PMID 17925868 DOI: 10.1371/journal.pone.0001020  1
2007 Leung AK, Sharp PA. microRNAs: a safeguard against turmoil? Cell. 130: 581-5. PMID 17719533 DOI: 10.1016/j.cell.2007.08.010  1
2007 Ebert MS, Neilson JR, Sharp PA. MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nature Methods. 4: 721-6. PMID 17694064 DOI: 10.1038/nmeth1079  1
2007 Wilker EW, van Vugt MA, Artim SA, Huang PH, Petersen CP, Reinhardt HC, Feng Y, Sharp PA, Sonenberg N, White FM, Yaffe MB. 14-3-3sigma controls mitotic translation to facilitate cytokinesis. Nature. 446: 329-32. PMID 17361185 DOI: 10.1038/nature05584  1
2007 Neilson JR, Zheng GX, Burge CB, Sharp PA. Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes & Development. 21: 578-89. PMID 17344418 DOI: 10.1101/gad.1522907  1
2007 Zerhouni EA, Sharp PA, Leavitt M, Niederhuber JE. Investiture of John E. Niederhuber, M.D., director of National Cancer Institute. The Oncologist. 12: 136-41. PMID 17296807 DOI: 10.1634/theoncologist.12-2-136  1
2007 Alemán LM, Doench J, Sharp PA. Comparison of siRNA-induced off-target RNA and protein effects. Rna (New York, N.Y.). 13: 385-95. PMID 17237357 DOI: 10.1261/rna.352507  1
2007 Schild-Poulter C, Shih A, Tantin D, Yarymowich NC, Soubeyrand S, Sharp PA, Haché RJ. DNA-PK phosphorylation sites on Oct-1 promote cell survival following DNA damage. Oncogene. 26: 3980-8. PMID 17213819 DOI: 10.1038/sj.onc.1210165  1
2007 Calabrese JM, Seila AC, Yeo GW, Sharp PA. RNA sequence analysis defines Dicer's role in mouse embryonic stem cells (Proceedings of the National Academy of Science of the United States of America (November 13, 2007) 104, 46, (18097-18102) DOI: 10.1073/pnas.0709193104) Proceedings of the National Academy of Sciences of the United States of America. 104: 21021. DOI: 10.1073/pnas.0711071105  1
2006 Leung AK, Sharp PA. Function and localization of microRNAs in mammalian cells. Cold Spring Harbor Symposia On Quantitative Biology. 71: 29-38. PMID 17381277 DOI: 10.1101/sqb.2006.71.049  1
2006 Calabrese JM, Sharp PA. Characterization of the short RNAs bound by the P19 suppressor of RNA silencing in mouse embryonic stem cells. Rna (New York, N.Y.). 12: 2092-102. PMID 17135486 DOI: 10.1261/rna.224606  1
2006 Leung AK, Calabrese JM, Sharp PA. Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules. Proceedings of the National Academy of Sciences of the United States of America. 103: 18125-30. PMID 17116888 DOI: 10.1073/pnas.0608845103  1
2006 Hakre S, Tussie-Luna MI, Ashworth T, Novina CD, Settleman J, Sharp PA, Roy AL. Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression. Molecular Cell. 24: 301-8. PMID 17052463 DOI: 10.1016/j.molcel.2006.09.005  1
2006 Cheng C, Yaffe MB, Sharp PA. A positive feedback loop couples Ras activation and CD44 alternative splicing. Genes & Development. 20: 1715-20. PMID 16818603 DOI: 10.1101/gad.1430906  1
2006 Petersen CP, Bordeleau ME, Pelletier J, Sharp PA. Short RNAs repress translation after initiation in mammalian cells. Molecular Cell. 21: 533-42. PMID 16483934 DOI: 10.1016/j.molcel.2006.01.031  1
2006 Cheng C, Sharp PA. Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion. Molecular and Cellular Biology. 26: 362-70. PMID 16354706 DOI: 10.1128/MCB.26.1.362-370.2006  1
2006 Miskevich F, Doench JG, Townsend MT, Sharp PA, Constantine-Paton M. RNA interference of Xenopus NMDAR NR1 in vitro and in vivo. Journal of Neuroscience Methods. 152: 65-73. PMID 16182372 DOI: 10.1016/j.jneumeth.2005.08.010  1
2005 Tantin D, Schild-Poulter C, Wang V, Haché RJ, Sharp PA. The octamer binding transcription factor Oct-1 is a stress sensor. Cancer Research. 65: 10750-8. PMID 16322220 DOI: 10.1158/0008-5472.CAN-05-2399  1
2005 Grishok A, Sharp PA. Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interference-related genes. Proceedings of the National Academy of Sciences of the United States of America. 102: 17360-5. PMID 16287966 DOI: 10.1073/pnas.0508989102  1
2005 Sharp PA. 1918 flu and responsible science. Science (New York, N.Y.). 310: 17. PMID 16210500 DOI: 10.1126/science.310.5745.17  1
2005 Hong JH, Hwang ES, McManus MT, Amsterdam A, Tian Y, Kalmukova R, Mueller E, Benjamin T, Spiegelman BM, Sharp PA, Hopkins N, Yaffe MB. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science (New York, N.Y.). 309: 1074-8. PMID 16099986 DOI: 10.1126/science.1110955  1
2005 Houbaviy HB, Dennis L, Jaenisch R, Sharp PA. Characterization of a highly variable eutherian microRNA gene. Rna (New York, N.Y.). 11: 1245-57. PMID 15987809 DOI: 10.1261/rna.2890305  1
2005 Sharp PA. The discovery of split genes and RNA splicing. Trends in Biochemical Sciences. 30: 279-81. PMID 15950867 DOI: 10.1016/j.tibs.2005.04.002  1
2005 Neilson JR, Sharp PA. Herpesviruses throw a curve ball: new insights into microRNA biogenesis and evolution. Nature Methods. 2: 252-4. PMID 15782215 DOI: 10.1038/nmeth0405-252  1
2005 Grishok A, Sinskey JL, Sharp PA. Transcriptional silencing of a transgene by RNAi in the soma of C. elegans. Genes & Development. 19: 683-96. PMID 15741313 DOI: 10.1101/gad.1247705  1
2005 Sharp PA. Phillip Sharp discusses RNAi, Nobel Prizes and entrepreneurial science. Drug Discovery Today. 10: 7-10. PMID 15676292 DOI: 10.1016/S1359-6446(04)03329-X  1
2004 Lee KB, Sharp PA. Transcription-dependent polyubiquitination of RNA polymerase II requires lysine 63 of ubiquitin. Biochemistry. 43: 15223-9. PMID 15568815 DOI: 10.1021/bi048719x  1
2004 Mansfield JH, Harfe BD, Nissen R, Obenauer J, Srineel J, Chaudhuri A, Farzan-Kashani R, Zuker M, Pasquinelli AE, Ruvkun G, Sharp PA, Tabin CJ, McManus MT. MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nature Genetics. 36: 1079-83. PMID 15361871 DOI: 10.1038/ng1421  1
2004 Fairbrother WG, Holste D, Burge CB, Sharp PA. Single nucleotide polymorphism-based validation of exonic splicing enhancers. Plos Biology. 2: E268. PMID 15340491 DOI: 10.1371/journal.pbio.0020268  1
2004 Novina CD, Sharp PA. The RNAi revolution. Nature. 430: 161-4. PMID 15241403 DOI: 10.1038/430161a  1
2004 Ventura A, Meissner A, Dillon CP, McManus M, Sharp PA, Van Parijs L, Jaenisch R, Jacks T. Cre-lox-regulated conditional RNA interference from transgenes. Proceedings of the National Academy of Sciences of the United States of America. 101: 10380-5. PMID 15240889 DOI: 10.1073/pnas.0403954101  1
2004 Fairbrother WG, Yeo GW, Yeh R, Goldstein P, Mawson M, Sharp PA, Burge CB. RESCUE-ESE identifies candidate exonic splicing enhancers in vertebrate exons. Nucleic Acids Research. 32: W187-90. PMID 15215377 DOI: 10.1093/nar/gkh393  1
2004 Doench JG, Sharp PA. Specificity of microRNA target selection in translational repression. Genes & Development. 18: 504-11. PMID 15014042 DOI: 10.1101/gad.1184404  1
2004 Wang VE, Tantin D, Chen J, Sharp PA. B cell development and immunoglobulin transcription in Oct-1-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 101: 2005-10. PMID 14762167 DOI: 10.1073/pnas.0307304101  1
2004 Nogueira ML, Wang VE, Tantin D, Sharp PA, Kristie TM. Herpes simplex virus infections are arrested in Oct-1-deficient cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 1473-8. PMID 14745036 DOI: 10.1073/pnas.0307300101  1
2004 Wang VE, Schmidt T, Chen J, Sharp PA, Tantin D. Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice. Molecular and Cellular Biology. 24: 1022-32. PMID 14729950 DOI: 10.1128/MCB.24.3.1022-1032.2004  1
2004 Tantin D, Tussie-Luna MI, Roy AL, Sharp PA. Regulation of immunoglobulin promoter activity by TFII-I class transcription factors. The Journal of Biological Chemistry. 279: 5460-9. PMID 14645227 DOI: 10.1074/jbc.M311177200  1
2003 Houbaviy HB, Murray MF, Sharp PA. Embryonic stem cell-specific MicroRNAs. Developmental Cell. 5: 351-8. PMID 12919684 DOI: 10.1016/S1534-5807(03)00227-2  1
2003 Song E, Lee SK, Dykxhoorn DM, Novina C, Zhang D, Crawford K, Cerny J, Sharp PA, Lieberman J, Manjunath N, Shankar P. Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages. Journal of Virology. 77: 7174-81. PMID 12805416 DOI: 10.1128/JVI.77.13.7174-7181.2003  1
2003 Dykxhoorn DM, Novina CD, Sharp PA. Killing the messenger: short RNAs that silence gene expression. Nature Reviews. Molecular Cell Biology. 4: 457-67. PMID 12778125 DOI: 10.1038/nrm1129  1
2003 Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, Sabatini DM, Chen IS, Hahn WC, Sharp PA, Weinberg RA, Novina CD. Lentivirus-delivered stable gene silencing by RNAi in primary cells. Rna (New York, N.Y.). 9: 493-501. PMID 12649500 DOI: 10.1261/rna.2192803  1
2003 Cheng C, Sharp PA. RNA polymerase II accumulation in the promoter-proximal region of the dihydrofolate reductase and gamma-actin genes. Molecular and Cellular Biology. 23: 1961-7. PMID 12612070 DOI: 10.1128/MCB.23.6.1961-1967.2003  1
2003 Doench JG, Petersen CP, Sharp PA. siRNAs can function as miRNAs. Genes & Development. 17: 438-42. PMID 12600936 DOI: 10.1101/gad.1064703  1
2003 Ge Q, McManus MT, Nguyen T, Shen CH, Sharp PA, Eisen HN, Chen J. RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription. Proceedings of the National Academy of Sciences of the United States of America. 100: 2718-23. PMID 12594334 DOI: 10.1073/pnas.0437841100  1
2002 McManus MT, Haines BB, Dillon CP, Whitehurst CE, van Parijs L, Chen J, Sharp PA. Small interfering RNA-mediated gene silencing in T lymphocytes. Journal of Immunology (Baltimore, Md. : 1950). 169: 5754-60. PMID 12421955 DOI: 10.4049/jimmunol.169.10.5754  1
2002 McManus MT, Sharp PA. Gene silencing in mammals by small interfering RNAs. Nature Reviews. Genetics. 3: 737-47. PMID 12360232 DOI: 10.1038/nrg908  1
2002 Scarr RB, Sharp PA. PDCD2 is a negative regulator of HCF-1 (C1). Oncogene. 21: 5245-54. PMID 12149646 DOI: 10.1038/sj.onc.1205647  1
2002 Fairbrother WG, Yeh RF, Sharp PA, Burge CB. Predictive identification of exonic splicing enhancers in human genes. Science (New York, N.Y.). 297: 1007-13. PMID 12114529 DOI: 10.1126/science.1073774  1
2002 McManus MT, Petersen CP, Haines BB, Chen J, Sharp PA. Gene silencing using micro-RNA designed hairpins. Rna (New York, N.Y.). 8: 842-50. PMID 12088155 DOI: 10.1017/S1355838202024032  1
2002 Novina CD, Murray MF, Dykxhoorn DM, Beresford PJ, Riess J, Lee SK, Collman RG, Lieberman J, Shankar P, Sharp PA. siRNA-directed inhibition of HIV-1 infection. Nature Medicine. 8: 681-6. PMID 12042777 DOI: 10.1038/nm725  1
2002 Lee KB, Wang D, Lippard SJ, Sharp PA. Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro. Proceedings of the National Academy of Sciences of the United States of America. 99: 4239-44. PMID 11904382 DOI: 10.1073/pnas.072068399  1
2002 Tantin D, Sharp PA. Mouse lymphoid cell line selected to have high immunoglobulin promoter activity. Molecular and Cellular Biology. 22: 1460-73. PMID 11839812 DOI: 10.1128/MCB.22.5.1460-1473.2002  1
2001 Sharp PA. RNA interference - 2001 Genes and Development. 15: 485-490. PMID 11238371 DOI: 10.1101/gad.880001  1
2001 Tuschl T, Sharp PA, Bartel DP. A ribozyme selected from variants of U6 snRNA promotes 2',5'-branch formation. Rna (New York, N.Y.). 7: 29-43. PMID 11214178 DOI: 10.1017/S1355838201001510  1
2001 Kim JB, Sharp PA. Positive Transcription Elongation Factor b Phosphorylates hSPT5 and RNA Polymerase II Carboxyl-terminal Domain Independently of Cyclin-dependent Kinase-activating Kinase Journal of Biological Chemistry. 276: 12317-12323. PMID 11145967 DOI: 10.1074/jbc.M010908200  1
2001 Chen K, Liu Q, Xie L, Sharp PA, Wang DIC. Engineering of a mammalian cell line for reduction of lactate formation and high monoclonal antibody production Biotechnology and Bioengineering. 72: 55-61. PMID 11084594 DOI: 10.1002/1097-0290(20010105)72:1<55::AID-BIT8>3.0.CO;2-4  1
2000 Sharp PA. View of life sciences in the 21st century Journal of Dermatological Science. 24: S1-S14. PMID 11137390 DOI: 10.1016/S0923-1811(00)00135-3  1
2000 Berget SM, Moore C, Sharp PA. Spliced segments at the 5' terminus of adenovirus 2 late mRNA. 1977 Reviews in Medical Virology. 10: 356-362; discussion . PMID 11114075  1
2000 Gilbert SL, Pehrson JR, Sharp PA. XIST RNA associates with specific regions of the inactive X chromatin. The Journal of Biological Chemistry. 275: 36491-4. PMID 11006266 DOI: 10.1074/jbc.C000409200  1
2000 Scarr RB, Smith MR, Beddall M, Sharp PA. A novel 50-kilodalton fragment of host cell factor 1 (C1) in G0 cells Molecular and Cellular Biology. 20: 3568-3575. PMID 10779346 DOI: 10.1128/MCB.20.10.3568-3575.2000  1
2000 Zamore PD, Tuschl T, Sharp PA, Bartel DP. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell. 101: 25-33. PMID 10778853 DOI: 10.1016/S0092-8674(00)80620-0  1
2000 Sharp PA, Zamore PD. Molecular biology. RNA interference. Science (New York, N.Y.). 287: 2431-3. PMID 10766620 DOI: 10.1126/science.287.5462.2431  1
2000 Blencowe BJ, Baurén G, Eldridge AG, Issner R, Nickerson JA, Rosonina E, Sharp PA. The SRm160/300 splicing coactivator subunits. Rna (New York, N.Y.). 6: 111-20. PMID 10668804 DOI: 10.1017/S1355838200991982  1
1999 Tuschl T, Zamore PD, Lehmann R, Bartel DP, Sharp PA. Targeted mRNA degradation by double-stranded RNA in vitro. Genes & Development. 13: 3191-7. PMID 10617568 DOI: 10.1101/gad.13.24.3191  1
1999 Page-McCaw PS, Amonlirdviman K, Sharp PA. PUF60: A novel U2AF65-related splicing activity Rna. 5: 1548-1560. PMID 10606266 DOI: 10.1017/S1355838299991938  1
1999 Tang H, Sharp PA. Transcriptional regulation of the murine 3' IgH enhancer by OCT-2 Immunity. 11: 517-526. PMID 10591177  1
1999 Gilbert SL, Sharp PA. Promoter-specific hypoacetylation of X-inactivated genes. Proceedings of the National Academy of Sciences of the United States of America. 96: 13825-30. PMID 10570157 DOI: 10.1073/pnas.96.24.13825  1
1999 Chasman D, Cepek K, Sharp PA, Pabo CO. Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface. Genes & Development. 13: 2650-7. PMID 10541551 DOI: 10.1101/gad.13.20.2650  1
1999 Kim JB, Yamaguchi Y, Wada T, Handa H, Sharp PA. Tat-SF1 protein associates with RAP30 and human SPT5 proteins. Molecular and Cellular Biology. 19: 5960-8. PMID 10454543  1
1999 Eldridge AG, Li Y, Sharp PA, Blencowe BJ. The SRm160/300 splicing coactivator is required for exon-enhancer function. Proceedings of the National Academy of Sciences of the United States of America. 96: 6125-30. PMID 10339552 DOI: 10.1073/pnas.96.11.6125  1
1999 Mitsui A, Sharp PA. Ubiquitination of RNA polymerase II large subunit signaled by phosphorylation of carboxyl-terminal domain Proceedings of the National Academy of Sciences of the United States of America. 96: 6054-6059. PMID 10339540 DOI: 10.1073/pnas.96.11.6054  1
1999 Sharp PA. RNAi and double-strand RNA Genes and Development. 13: 139-141. PMID 9925636  1
1998 Burge CB, Padgett RA, Sharp PA. Evolutionary fates and origins of U12-type introns. Molecular Cell. 2: 773-85. PMID 9885565  1
1998 Lim LP, Sharp PA. Alternative splicing of the fibronectin EIIIB exon depends on specific TGCATG repeats Molecular and Cellular Biology. 18: 3900-3906. PMID 9632774  1
1998 Tuschl T, Sharp PA, Bartel DP. Selection in vitro of novel ribozymes from a partially randomized U2 and U6 snRNA library. The Embo Journal. 17: 2637-50. PMID 9564046 DOI: 10.1093/emboj/17.9.2637  1
1998 Blencowe BJ, Issner R, Nickerson JA, Sharp PA. A coactivator of pre-mRNA splicing. Genes & Development. 12: 996-1009. PMID 9531537  1
1997 Sharp PA, Burge CB. Classification of introns: U2-type or U12-type. Cell. 91: 875-9. PMID 9428511 DOI: 10.1016/S0092-8674(00)80479-1  1
1997 Jones G, Sharp PA. Ultraspiracle: An invertebrate nuclear receptor for juvenile hormones Proceedings of the National Academy of Sciences of the United States of America. 94: 13499-13503. PMID 9391054 DOI: 10.1073/pnas.94.25.13499  1
1997 Query CC, McCaw PS, Sharp PA. A minimal spliceosomal complex A recognizes the branch site and polypyrimidine tract Molecular and Cellular Biology. 17: 2944-2953. PMID 9111366  1
1997 Kim JS, Kim J, Cepek KL, Sharp PA, Pabo CO. Design of TATA box-binding protein/zinc finger fusions for targeted regulation of gene expression. Proceedings of the National Academy of Sciences of the United States of America. 94: 3616-20. PMID 9108026 DOI: 10.1073/pnas.94.8.3616  1
1997 Shykind BM, Kim J, Stewart L, Champoux JJ, Sharp PA. Topoisomerase I enhances TFIID-TFIIA complex assembly during activation of transcription. Genes & Development. 11: 397-407. PMID 9030691  1
1997 Macmillan AM, Mccaw PS, Crispino JD, Sharp PA. SC35-mediated reconstitution of splicing in U2AF-depleted nuclear extract Proceedings of the National Academy of Sciences of the United States of America. 94: 133-136. PMID 8990173 DOI: 10.1073/pnas.94.1.133  1
1996 Crispino JD, Mermoud JE, Lamond AI, Sharp PA. Cis-acting elements distinct from the 5' splice site promote U1-independent pre-mRNA splicing. Rna (New York, N.Y.). 2: 664-73. PMID 8756409  1
1996 Mortillaro MJ, Blencowe BJ, Wei X, Nakayasu H, Du L, Warren SL, Sharp PA, Berezney R. A hyperphosphorylated form of the large subunit of RNA polymerase II is associated with splicing complexes and the nuclear matrix. Proceedings of the National Academy of Sciences of the United States of America. 93: 8253-7. PMID 8710856 DOI: 10.1073/pnas.93.16.8253  1
1996 Kim J, Parvin JD, Shykind BM, Sharp PA. A negative cofactor containing Dr1/p19 modulates transcription with TFIIA in a promoter-specific fashion. The Journal of Biological Chemistry. 271: 18405-12. PMID 8702484 DOI: 10.1074/jbc.271.31.18405  1
1995 Shykind BM, Kim J, Sharp PA. Activation of the TFIID-TFIIA complex with HMG-2. Genes & Development. 9: 1354-65. PMID 7797075  1
1995 Blencowe BJ, Issner R, Kim J, Mccaw P, Sharp PA. New proteins related to the Ser-Arg family of splicing factors. Rna (New York, N.Y.). 1: 852-65. PMID 7493330  1
1994 Crispino JD, Blencowe BJ, Sharp PA. Complementation by SR proteins of pre-mRNA splicing reactions depleted of U1 snRNP. Science (New York, N.Y.). 265: 1866-9. PMID 8091213  1
1994 Parvin JD, Shykind BM, Meyers RE, Kim J, Sharp PA. Multiple sets of basal factors initiate transcription by RNA polymerase II. The Journal of Biological Chemistry. 269: 18414-21. PMID 8034589  1
1994 Blencowe BJ, Nickerson JA, Issner R, Penman S, Sharp PA. Association of nuclear matrix antigens with exon-containing splicing complexes. The Journal of Cell Biology. 127: 593-607. PMID 7962048 DOI: 10.1083/jcb.127.3.593  1
1994 Query CC, Moore MJ, Sharp PA. Branch nucleophile selection in pre-mRNA splicing: evidence for the bulged duplex model. Genes & Development. 8: 587-97. PMID 7926752  0.88
1993 Moore MJ, Sharp PA. Evidence for two active sites in the spliceosome provided by stereochemistry of pre-mRNA splicing. Nature. 365: 364-8. PMID 8397340 DOI: 10.1038/365364a0  1
1993 Kjems J, Sharp PA. The basic domain of Rev from human immunodeficiency virus type 1 specifically blocks the entry of U4/U6.U5 small nuclear ribonucleoprotein in spliceosome assembly. Journal of Virology. 67: 4769-76. PMID 8331728  0.92
1992 Moore MJ, Sharp PA. Site-specific modification of pre-mRNA: the 2'-hydroxyl groups at the splice sites. Science (New York, N.Y.). 256: 992-7. PMID 1589782  1
1992 Kjems J, Calnan BJ, Frankel AD, Sharp PA. Specific binding of a basic peptide from HIV-1 Rev. The Embo Journal. 11: 1119-29. PMID 1547776  0.92
1991 Kjems J, Brown M, Chang DD, Sharp PA. Structural analysis of the interaction between the human immunodeficiency virus Rev protein and the Rev response element. Proceedings of the National Academy of Sciences of the United States of America. 88: 683-7. PMID 1992459  0.92
1991 Kjems J, Frankel AD, Sharp PA. Specific regulation of mRNA splicing in vitro by a peptide from HIV-1 Rev. Cell. 67: 169-78. PMID 1913815 DOI: 10.1016/0092-8674(91)90580-R  0.92
1991 Buratowski S, Sopta M, Greenblatt J, Sharp PA. RNA polymerase II-associated proteins are required for a DNA conformation change in the transcription initiation complex. Proceedings of the National Academy of Sciences of the United States of America. 88: 7509-13. PMID 1881889  0.96
1990 Buratowski S, Sharp PA. Transcription initiation complexes and upstream activation with RNA polymerase II lacking the C-terminal domain of the largest subunit. Molecular and Cellular Biology. 10: 5562-4. PMID 2398901  1
1989 Buratowski S, Hahn S, Guarente L, Sharp PA. Five intermediate complexes in transcription initiation by RNA polymerase II. Cell. 56: 549-61. PMID 2917366 DOI: 10.1016/0092-8674(89)90578-3  1
1989 Hahn S, Buratowski S, Sharp PA, Guarente L. Identification of a yeast protein homologous in function to the mammalian general transcription factor, TFIIA. The Embo Journal. 8: 3379-82. PMID 2684641  1
1989 Chodosh LA, Buratowski S, Sharp PA. A yeast protein possesses the DNA-binding properties of the adenovirus major late transcription factor. Molecular and Cellular Biology. 9: 820-2. PMID 2651905  1
1989 Hahn S, Buratowski S, Sharp PA, Guarente L. Yeast TATA-binding protein TFIID binds to TATA elements with both consensus and nonconsensus DNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 86: 5718-22. PMID 2569738 DOI: 10.1073/pnas.86.15.5718  1
1989 Hahn S, Buratowski S, Sharp PA, Guarente L. Isolation of the gene encoding the yeast TATA binding protein TFIID: a gene identical to the SPT15 suppressor of Ty element insertions. Cell. 58: 1173-81. PMID 2550146 DOI: 10.1016/0092-8674(89)90515-1  0.96
1988 Watanabe H, Imai T, Sharp PA, Handa H. Identification of two transcription factors that bind to specific elements in the promoter of the adenovirus early-region 4. Molecular and Cellular Biology. 8: 1290-300. PMID 3367909  1
1988 Buratowski S, Hahn S, Sharp PA, Guarente L. Function of a yeast TATA element-binding protein in a mammalian transcription system. Nature. 334: 37-42. PMID 3290687 DOI: 10.1038/334037a0  1
1988 Lamond AI, Konarska MM, Grabowski PJ, Sharp PA. Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein. Proceedings of the National Academy of Sciences of the United States of America. 85: 411-5. PMID 2963332  1
1987 Hanaka S, Nishigaki T, Sharp PA, Handa H. Regulation of in vitro and in vivo transcription of early-region IV of adenovirus type 5 by multiple cis-acting elements. Molecular and Cellular Biology. 7: 2578-87. PMID 3614200  1
1987 Sharp PA, Konarksa MM, Grabowski PJ, Lamond AI, Marciniak R, Seiler SR. Splicing of messenger RNA precursors. Cold Spring Harbor Symposia On Quantitative Biology. 52: 277-85. PMID 3331341  1
1987 Lamond AI, Konarska MM, Sharp PA. A mutational analysis of spliceosome assembly: evidence for splice site collaboration during spliceosome formation. Genes & Development. 1: 532-43. PMID 2824284  0.96
1986 Jat PS, Cepko CL, Mulligan RC, Sharp PA. Recombinant retroviruses encoding simian virus 40 large T antigen and polyomavirus large and middle T antigens. Molecular and Cellular Biology. 6: 1204-17. PMID 3023876  1
1986 Padgett RA, Grabowski PJ, Konarska MM, Seiler S, Sharp PA. Splicing of messenger RNA precursors. Annual Review of Biochemistry. 55: 1119-50. PMID 2943217 DOI: 10.1146/  0.68
1985 Padgett RA, Konarska MM, Aebi M, Hornig H, Weissmann C, Sharp PA. Nonconsensus branch-site sequences in the in vitro splicing of transcripts of mutant rabbit beta-globin genes. Proceedings of the National Academy of Sciences of the United States of America. 82: 8349-53. PMID 3866228  0.68
1985 Konarska MM, Padgett RA, Sharp PA. Trans splicing of mRNA precursors in vitro. Cell. 42: 165-71. PMID 3848348 DOI: 10.1016/S0092-8674(85)80112-4  1
1985 Kingston RE, Baldwin AS, Sharp PA. Transcription control by oncogenes. Cell. 41: 3-5. PMID 2986847  1
1985 Konarska MM, Grabowski PJ, Padgett RA, Sharp PA. Characterization of the branch site in lariat RNAs produced by splicing of mRNA precursors. Nature. 313: 552-7. PMID 2578627 DOI: 10.1038/313552a0  1
1984 Grabowski PJ, Padgett RA, Sharp PA. Messenger RNA splicing in vitro: an excised intervening sequence and a potential intermediate. Cell. 37: 415-27. PMID 6722880 DOI: 10.1016/0092-8674(84)90372-6  1
1984 Handa H, Sharp PA. Requirement for distal upstream sequences for maximal transcription in vitro of early region IV of adenovirus. Molecular and Cellular Biology. 4: 791-8. PMID 6717442  1
1984 Hardy SF, Grabowski PJ, Padgett RA, Sharp PA. Cofactor requirements of splicing of purified messenger RNA precursors. Nature. 308: 375-7. PMID 6709044 DOI: 10.1038/308375a0  1
1984 Konarska MM, Padgett RA, Sharp PA. Recognition of cap structure in splicing in vitro of mRNA precursors. Cell. 38: 731-6. PMID 6567484 DOI: 10.1016/0092-8674(84)90268-X  1
1984 Kingston RE, Baldwin AS, Sharp PA. Regulation of heat shock protein 70 gene expression by c-myc. Nature. 312: 280-2. PMID 6438521 DOI: 10.1038/312280a0  1
1984 Padgett RA, Konarska MM, Grabowski PJ, Hardy SF, Sharp PA. Lariat RNA's as intermediates and products in the splicing of messenger RNA precursors. Science (New York, N.Y.). 225: 898-903. PMID 6206566  0.68
1984 Kingston RE, Kaufman RJ, Sharp PA. Regulation of transcription of the adenovirus EII promoter by EIa gene products: absence of sequence specificity. Molecular and Cellular Biology. 4: 1970-7. PMID 6095034  1
1983 Kaufman RJ, Sharp PA, Latt SA. Evolution of chromosomal regions containing transfected and amplified dihydrofolate reductase sequences. Molecular and Cellular Biology. 3: 699-711. PMID 6855772 DOI: 10.1128/mcb.3.4.699  0.88
1983 Cepko CL, Sharp PA. Analysis of Ad5 hexon and 100K ts mutants using conformation-specific monoclonal antibodies. Virology. 129: 137-54. PMID 6612996 DOI: 10.1016/0042-6822(83)90402-6  1
1983 Padgett RA, Hardy SF, Sharp PA. Splicing of adenovirus RNA in a cell-free transcription system. Proceedings of the National Academy of Sciences of the United States of America. 80: 5230-4. PMID 6577417  1
1983 Laski FA, Fire AZ, RajBhandary UL, Sharp PA. Characterization of tRNA precursor splicing in mammalian extracts. The Journal of Biological Chemistry. 258: 11974-80. PMID 6413507  1
1983 Cepko CL, Sharp PA. Aberrant distribution of human adenovirus type 2 late proteins in monkey kidney cells. Journal of Virology. 46: 302-6. PMID 6402607  1
1983 Cepko CL, Whetstone CA, Sharp PA. Adenovirus hexon monoclonal antibody that is group specific and potentially useful as a diagnostic reagent. Journal of Clinical Microbiology. 17: 360-4. PMID 6339552  1
1983 Handa H, Kingston RE, Sharp PA. Inhibition of adenovirus early region IV transcription in vitro by a purified viral DNA binding protein. Nature. 302: 545-7. PMID 6300688  0.96
1983 Padgett RA, Mount SM, Steitz JA, Sharp PA. Splicing of messenger RNA precursors is inhibited by antisera to small nuclear ribonucleoprotein. Cell. 35: 101-7. PMID 6194895 DOI: 10.1016/0092-8674(83)90212-X  1
1983 Horowitz M, Cepko CL, Sharp PA. Expression of chimeric genes in the early region of SV40. Journal of Molecular and Applied Genetics. 2: 147-59. PMID 6192195  1
1983 Kaufman RJ, Sharp PA. Growth-dependent expression of dihydrofolate reductase mRNA from modular cDNA genes. Molecular and Cellular Biology. 3: 1598-608. PMID 6138708 DOI: 10.1128/mcb.3.9.1598  0.88
1982 Cepko CL, Sharp PA. Assembly of adenovirus major capsid protein is mediated by a nonvirion protein. Cell. 31: 407-15. PMID 7159928 DOI: 10.1016/0092-8674(82)90134-9  1
1982 Kaufman RJ, Sharp PA. Amplification and expression of sequences cotransfected with a modular dihydrofolate reductase complementary dna gene. Journal of Molecular Biology. 159: 601-21. PMID 6292436 DOI: 10.1016/0022-2836(82)90103-6  0.88
1982 Kaufman RJ, Sharp PA. Construction of a modular dihydrofolate reductase cDNA gene: analysis of signals utilized for efficient expression. Molecular and Cellular Biology. 2: 1304-19. PMID 6131378 DOI: 10.1128/mcb.2.11.1304  0.88
1981 Cepko CL, Changelian PS, Sharp PA. Immunoprecipitation with two-dimensional pools as a hybridoma screening technique: production and characterization of monoclonal antibodies against adenovirus 2 proteins. Virology. 110: 385-401. PMID 7222481  1
1981 Ricciardi RP, Jones RL, Cepko CL, Sharp PA, Roberts BE. Expression of early adenovirus genes requires a viral encoded acidic polypeptide. Proceedings of the National Academy of Sciences of the United States of America. 78: 6121-5. PMID 6947217 DOI: 10.1073/pnas.78.10.6121  0.96
1981 Cepko CL, Hansen U, Handa H, Sharp PA. Sequential transcription-translation of simian virus 40 by using mammalian cell extracts. Molecular and Cellular Biology. 1: 919-31. PMID 6287212 DOI: 10.1128/MCB.1.10.919  1
1981 Handa H, Kaufman RJ, Manley J, Gefter M, Sharp PA. Transcription of Simian virus 40 DNA in a HeLa whole cell extract. The Journal of Biological Chemistry. 256: 478-82. PMID 6256354  1
1980 Donoghue DJ, Goldfarb MP, Sharp PA, Weinberg RA. Organization of murine sarcoma virus genomes. Cold Spring Harbor Symposia On Quantitative Biology. 44: 721-6. PMID 6253206 DOI: 10.1101/SQB.1980.044.01.077  1
1980 Handa H, Sharp PA. Expression of early and late simian virus 40 transcripts in the absence of protein synthesis. Journal of Virology. 34: 592-7. PMID 6247498  1
1979 Donoghue DJ, Sharp PA, Weinberg RA. An MSV-specific subgenomic mRNA in MSV-transformed G8-124 cells. Cell. 17: 53-63. PMID 556552 DOI: 10.1016/0092-8674(79)90294-0  0.88
1979 Donoghue DJ, Sharp PA, Weinberg RA. Comparative study of different isolates of murine sarcoma virus. Journal of Virology. 32: 1015-27. PMID 229256  0.88
1978 Donoghue DJ, Sharp PA. Construction of a hybrid bacteriophage-plasmid recombinant DNA vector. Journal of Bacteriology. 136: 1192-6. PMID 363694  1
1978 Donoghue DJ, Sharp PA. Replication of colicin E1 plasmid DNA in vivo requires no plasmid-encoded proteins. Journal of Bacteriology. 133: 1287-94. PMID 346567  1
1978 Donoghue DJ, Rothenberg E, Hopkins N, Baltimore D, Sharp PA. Heteroduplex analysis of the nonhomology region between Moloney MuLV and the dual host range derivative HIX virus. Cell. 14: 959-70. PMID 210960 DOI: 10.1016/0092-8674(78)90350-1  0.88
1977 Donoghue DJ, Sharp PA. An improved bacteriophage lambda vector: construction of model recombinants coding for kanamycin resistance. Gene. 1: 209-27. PMID 338417 DOI: 10.1016/0378-1119(77)90046-4  1
1973 Sharp PA, Cohen SN, Davidson N. Electron microscope heteroduplex studies of sequence relations among plasmids of Escherichia coli. II. Structure of drug resistance (R) factors and F factors. Journal of Molecular Biology. 75: 235-55. PMID 4580676  0.52
1972 Sharp PA, Hsu M, Davidson N. Note on the structure of prophage lambda. Journal of Molecular Biology. 71: 499-501. PMID 4635993  0.52
1972 Sharp PA, Hsu MT, Otsubo E, Davidson N. Electron microscope heteroduplex studies of sequence relations among plasmids of Escherichia coli. I. Structure of F-prime factors. Journal of Molecular Biology. 71: 471-97. PMID 4564488  0.52
1972 Kim J, Sharp PA, Davidson N. Electron microscope studies of heteroduplex DNA from a deletion mutant of bacteriophage phiX-174. Proceedings of the National Academy of Sciences of the United States of America. 69: 1948-52. PMID 4505672  0.72
1970 Sharp PA, Bloomfield VA. Binding of proflavine and ethidium bromide to two forms of T2 bacteriophage with different sedimentation coefficients. Biochemical and Biophysical Research Communications. 39: 407-13. PMID 5421943 DOI: 10.1016/0006-291X(70)90592-9  1
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