Tobias c Walther - Publications

Affiliations: 
Harvard Medical School, Boston, MA, United States 
Area:
Metabolism, Cell Biology, Membranes, Organelles, Lipids,

68 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Sui X, Wang K, Gluchowski NL, Elliott SD, Liao M, Walther TC, Farese RV. Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme. Nature. 581: 323-328. PMID 32433611 DOI: 10.1038/s41586-020-2289-6  0.52
2020 Petit CS, Lee JJ, Boland S, Swarup S, Christiano R, Lai ZW, Mejhert N, Elliott SD, McFall D, Haque S, Huang EJ, Bronson RT, Harper JW, Farese RV, Walther TC. Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant mice, a model of motor neuron degeneration. Proceedings of the National Academy of Sciences of the United States of America. PMID 32345721 DOI: 10.1073/pnas.1913956117  0.52
2020 Mejhert N, Kuruvilla L, Gabriel KR, Elliott SD, Guie MA, Wang H, Lai ZW, Lane EA, Christiano R, Danial NN, Farese RV, Walther TC. Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression. Molecular Cell. PMID 32023484 DOI: 10.1016/j.molcel.2020.01.014  0.52
2019 Chung J, Wu X, Lambert TJ, Lai ZW, Walther TC, Farese RV. LDAF1 and Seipin Form a Lipid Droplet Assembly Complex. Developmental Cell. PMID 31708432 DOI: 10.1016/j.devcel.2019.10.006  0.52
2019 Walther TC, Farese RV. Un-phased: Lipid Droplets Modulate the Bioavailability of Antibiotics. Developmental Cell. 50: 530-532. PMID 31505174 DOI: 10.1016/j.devcel.2019.08.009  0.52
2019 Gluchowski NL, Gabriel KR, Chitraju C, Bronson RT, Mejhert N, Boland S, Wang K, Lai ZW, Farese RV, Walther TC. Hepatocyte Deletion of Triglyceride-Synthesis Enzyme DGAT2 Reduces Steatosis without Increasing Inflammation or Fibrosis. Hepatology (Baltimore, Md.). PMID 31081165 DOI: 10.1002/hep.30765  0.52
2019 Chitraju C, Walther TC, Farese RV. The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes. Journal of Lipid Research. 60: 1112-1120. PMID 30936184 DOI: 10.1194/jlr.M093112  0.52
2019 Piccolis M, Bond LM, Kampmann M, Pulimeno P, Chitraju C, Jayson CBK, Vaites LP, Boland S, Lai ZW, Gabriel KR, Elliott SD, Paulo JA, Harper JW, Weissman JS, Walther TC, et al. Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids. Molecular Cell. PMID 30846318 DOI: 10.1016/j.molcel.2019.01.036  0.52
2018 Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, ... ... Walther TC, et al. Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Molecular Cell. PMID 30527540 DOI: 10.1016/j.molcel.2018.11.028  0.52
2018 Krahmer N, Najafi B, Schueder F, Quagliarini F, Steger M, Seitz S, Kasper R, Salinas F, Cox J, Uhlenhaut NH, Walther TC, Jungmann R, Zeigerer A, Borner GHH, Mann M. Organellar Proteomics and Phospho-Proteomics Reveal Subcellular Reorganization in Diet-Induced Hepatic Steatosis. Developmental Cell. 47: 205-221.e7. PMID 30352176 DOI: 10.1016/j.devcel.2018.09.017  0.52
2018 Sui X, Arlt H, Brock KP, Lai ZW, DiMaio F, Marks DS, Liao M, Farese RV, Walther TC. Cryo-electron microscopy structure of the lipid droplet-formation protein seipin. The Journal of Cell Biology. PMID 30327422 DOI: 10.1083/jcb.201809067  0.52
2018 Nguyen AD, Nguyen TA, Singh RK, Eberlé D, Zhang J, Abate JP, Robles A, Koliwad S, Huang EJ, Maxfield FR, Walther TC, Farese RV. Progranulin in the hematopoietic compartment protects mice from atherosclerosis. Atherosclerosis. 277: 145-154. PMID 30212683 DOI: 10.1016/j.atherosclerosis.2018.08.042  0.52
2018 Jayson CBK, Arlt H, Fischer AW, Lai ZW, Farese RV, Walther TC. Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells. Molecular Biology of the Cell. mbcE18050282. PMID 29949452 DOI: 10.1091/mbc.E18-05-0282  0.52
2018 Nguyen AD, Nguyen TA, Zhang J, Devireddy S, Zhou P, Karydas AM, Xu X, Miller BL, Rigo F, Ferguson SM, Huang EJ, Walther TC, Farese RV. Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay. Proceedings of the National Academy of Sciences of the United States of America. PMID 29511098 DOI: 10.1073/pnas.1722344115  0.52
2018 Li Z, Lai ZW, Christiano R, Gazos-Lopes F, Walther TC, Farese RV. Global Analyses of Selective Insulin Resistance in Hepatocytes due to Palmitate Lipotoxicity. Molecular & Cellular Proteomics : McP. PMID 29414761 DOI: 10.1074/mcp.RA117.000560  0.52
2018 Prévost C, Sharp ME, Kory N, Lin Q, Voth GA, Farese RV, Walther TC. Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid Droplets. Developmental Cell. 44: 73-86.e4. PMID 29316443 DOI: 10.1016/j.devcel.2017.12.011  0.52
2017 Inloes JM, Kiosses WB, Wang H, Walther TC, Farese RV, Cravatt BF. Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets. Biochemistry. PMID 29278326 DOI: 10.1021/acs.biochem.7b01028  0.52
2017 Walther TC, Chung J, Farese RV. Lipid Droplet Biogenesis. Annual Review of Cell and Developmental Biology. PMID 28793795 DOI: 10.1146/annurev-cellbio-100616-060608  0.52
2017 Chitraju C, Mejhert N, Haas JT, Diaz-Ramirez LG, Grueter CA, Imbriglio JE, Pinto S, Koliwad SK, Walther TC, Farese RV. Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis. Cell Metabolism. 26: 407-418.e3. PMID 28768178 DOI: 10.1016/j.cmet.2017.07.012  0.52
2017 Gluchowski NL, Becuwe M, Walther TC, Farese RV. Lipid droplets and liver disease: from basic biology to clinical implications. Nature Reviews. Gastroenterology & Hepatology. 14: 343-355. PMID 28428634 DOI: 10.1038/nrgastro.2017.32  0.52
2017 Gluchowski NL, Chitraju C, Picoraro JA, Mejhert N, Pinto S, Xin W, Kamin DS, Winter HS, Chung WK, Walther TC, Farese RV. Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea. Journal of Lipid Research. PMID 28373485 DOI: 10.1194/jlr.P075119  0.52
2016 Kory N, Grond S, Kamat SS, Li Z, Krahmer N, Chitraju C, Zhou P, Fröhlich F, Semova I, Ejsing C, Zechner R, Cravatt BF, Farese RV, Walther TC. Mice Lacking Lipid Droplet-Associated Hydrolase, a Gene Linked to Human Prostate Cancer, Have Normal Cholesterol Ester Metabolism. Journal of Lipid Research. PMID 27836991 DOI: 10.1194/jlr.M072538  0.52
2016 Fröhlich F, Olson DK, Christiano R, Farese RV, Walther TC. Proteomic and phosphoproteomic analyses of yeast reveal the global cellular response to sphingolipid depletion. Proteomics. 16: 2759-2763. PMID 27717283 DOI: 10.1002/pmic.201600269  0.52
2016 Wang H, Becuwe M, Housden BE, Chitraju C, Porras AJ, Graham MM, Liu XN, Thiam AR, Savage DB, Agarwal AK, Garg A, Olarte MJ, Lin Q, Fröhlich F, Hannibal-Bach HK, ... ... Walther TC, et al. Seipin is required for converting nascent to mature lipid droplets. Elife. 5. PMID 27564575 DOI: 10.7554/eLife.16582  0.52
2016 Kory N, Farese RV, Walther TC. Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets. Trends in Cell Biology. 26: 535-546. PMID 26995697 DOI: 10.1016/j.tcb.2016.02.007  0.52
2016 Farese RV, Walther TC. Lipid droplets go nuclear. The Journal of Cell Biology. 212: 7-8. PMID 26728852 DOI: 10.1083/jcb.201512056  0.52
2015 Fröhlich F, Petit C, Kory N, Christiano R, Hannibal-Bach HK, Graham M, Liu X, Ejsing CS, Farese RV, Walther TC. The GARP complex is required for cellular sphingolipid homeostasis. Elife. 4. PMID 26357016 DOI: 10.7554/eLife.08712  0.52
2015 Kory N, Thiam AR, Farese RV, Walther TC. Protein Crowding Is a Determinant of Lipid Droplet Protein Composition. Developmental Cell. 34: 351-63. PMID 26212136 DOI: 10.1016/j.devcel.2015.06.007  0.52
2015 Shibuya A, Margulis N, Christiano R, Walther TC, Barlowe C. The Erv41-Erv46 complex serves as a retrograde receptor to retrieve escaped ER proteins. The Journal of Cell Biology. 208: 197-209. PMID 25583996 DOI: 10.1083/jcb.201408024  0.52
2015 Olson DK, Fröhlich F, Christiano R, Hannibal-Bach HK, Ejsing CS, Walther TC. Rom2-dependent phosphorylation of Elo2 controls the abundance of very long-chain fatty acids. The Journal of Biological Chemistry. 290: 4238-47. PMID 25519905 DOI: 10.1074/jbc.M114.629279  0.52
2014 Payne F, Lim K, Girousse A, Brown RJ, Kory N, Robbins A, Xue Y, Sleigh A, Cochran E, Adams C, Borman AD, Russel-Jones D, Gorden P, Semple RK, Saudek V, ... ... Walther TC, et al. Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease Proceedings of the National Academy of Sciences of the United States of America. 111: 8901-8906. PMID 24889630 DOI: 10.1073/pnas.1408523111  0.52
2014 Currie E, Guo X, Christiano R, Chitraju C, Kory N, Harrison K, Haas J, Walther TC, Farese RV. High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation. Journal of Lipid Research. 55: 1465-1477. PMID 24868093 DOI: 10.1194/jlr.M050229  0.52
2014 Wilfling F, Haas JT, Walther TC, Farese RV. Lipid droplet biogenesis. Current Opinion in Cell Biology. 29: 39-45. PMID 24736091 DOI: 10.1016/j.ceb.2014.03.008  0.52
2014 Bazzini AA, Johnstone TG, Christiano R, Mackowiak SD, Obermayer B, Fleming ES, Vejnar CE, Lee MT, Rajewsky N, Walther TC, Giraldez AJ. Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation. The Embo Journal. 33: 981-93. PMID 24705786 DOI: 10.1002/embj.201488411  0.52
2014 Wilfling F, Thiam AR, Olarte MJ, Wang J, Beck R, Gould TJ, Allgeyer ES, Pincet F, Bewersdorf J, Farese RV, Walther TC. Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting. Elife. 3: e01607. PMID 24497546 DOI: 10.7554/eLife.01607  0.52
2014 Harrison MS, Hung CS, Liu TT, Christiano R, Walther TC, Burd CG. A mechanism for retromer endosomal coat complex assembly with cargo. Proceedings of the National Academy of Sciences of the United States of America. 111: 267-72. PMID 24344282 DOI: 10.1073/pnas.1316482111  0.52
2013 Thiam AR, Farese RV, Walther TC. The biophysics and cell biology of lipid droplets. Nature Reviews. Molecular Cell Biology. 14: 775-86. PMID 24220094 DOI: 10.1038/nrm3699  0.52
2013 Currie E, Schulze A, Zechner R, Walther TC, Farese RV. Cellular fatty acid metabolism and cancer. Cell Metabolism. 18: 153-61. PMID 23791484 DOI: 10.1016/j.cmet.2013.05.017  0.52
2013 Krahmer N, Farese RV, Walther TC. Balancing the fat: Lipid droplets and human disease Embo Molecular Medicine. 5: 905-915. PMID 23740690 DOI: 10.1002/emmm.201100671  0.52
2013 Wilfling F, Wang H, Haas JT, Krahmer N, Gould TJ, Uchida A, Cheng JX, Graham M, Christiano R, Fröhlich F, Liu X, Buhman KK, Coleman RA, Bewersdorf J, Farese RV, ... Walther TC, et al. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Developmental Cell. 24: 384-99. PMID 23415954 DOI: 10.1016/j.devcel.2013.01.013  0.52
2013 Nguyen AD, Nguyen TA, Cenik B, Yu G, Herz J, Walther TC, Davidson WS, Farese RV. Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL). The Journal of Biological Chemistry. 288: 8627-35. PMID 23364791 DOI: 10.1074/jbc.M112.441949  0.52
2013 Krahmer N, Hilger M, Kory N, Wilfling F, Stoehr G, Mann M, Farese RV, Walther TC. Protein correlation profiles identify lipid droplet proteins with high confidence. Molecular & Cellular Proteomics : McP. 12: 1115-26. PMID 23319140 DOI: 10.1074/mcp.M112.020230  0.52
2012 Haas JT, Winter HS, Lim E, Kirby A, Blumenstiel B, DeFelice M, Gabriel S, Jalas C, Branski D, Grueter CA, Toporovski MS, Walther TC, Daly MJ, Farese RV. DGAT1 mutation is linked to a congenital diarrheal disorder. The Journal of Clinical Investigation. 122: 4680-4. PMID 23114594 DOI: 10.1172/JCI64873  0.52
2012 Moreira KE, Schuck S, Schrul B, Fröhlich F, Moseley JB, Walther TC, Walter P. Seg1 controls eisosome assembly and shape. The Journal of Cell Biology. 198: 405-20. PMID 22869600 DOI: 10.1083/jcb.201202097  0.52
2012 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Molecular & Cellular Proteomics : McP. 11: 1510-22. PMID 22865919 DOI: 10.1074/mcp.M112.017251  0.52
2012 Roczniak-Ferguson A, Petit CS, Froehlich F, Qian S, Ky J, Angarola B, Walther TC, Ferguson SM. The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis. Science Signaling. 5: ra42. PMID 22692423 DOI: 10.1126/scisignal.2002790  0.52
2012 Farese RV, Zechner R, Newgard CB, Walther TC. The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance Cell Metabolism. 15: 570-573. PMID 22560209 DOI: 10.1016/j.cmet.2012.03.004  0.52
2012 Walther TC, Farese RV. Lipid droplets and cellular lipid metabolism Annual Review of Biochemistry. 81: 687-714. PMID 22524315 DOI: 10.1146/annurev-biochem-061009-102430  0.52
2011 Karotki L, Huiskonen JT, Stefan CJ, Ziółkowska NE, Roth R, Surma MA, Krogan NJ, Emr SD, Heuser J, Grünewald K, Walther TC. Eisosome proteins assemble into a membrane scaffold. The Journal of Cell Biology. 195: 889-902. PMID 22123866 DOI: 10.1083/jcb.201104040  0.52
2011 Krahmer N, Guo Y, Wilfling F, Hilger M, Lingrell S, Heger K, Newman HW, Schmidt-Supprian M, Vance DE, Mann M, Farese RV, Walther TC. Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase. Cell Metabolism. 14: 504-15. PMID 21982710 DOI: 10.1016/j.cmet.2011.07.013  0.52
2011 Fei W, Shui G, Zhang Y, Krahmer N, Ferguson C, Kapterian TS, Lin RC, Dawes IW, Brown AJ, Li P, Huang X, Parton RG, Wenk MR, Walther TC, Yang H. A role for phosphatidic acid in the formation of "supersized" lipid droplets. Plos Genetics. 7: e1002201. PMID 21829381 DOI: 10.1371/journal.pgen.1002201  0.52
2011 Bewersdorf J, Farese RV, Walther TC. A new way to look at fat Nature Methods. 8: 132-133. PMID 21278725 DOI: 10.1038/nmeth0211-132  0.52
2010 Aguilar PS, Fröhlich F, Rehman M, Shales M, Ulitsky I, Olivera-Couto A, Braberg H, Shamir R, Walter P, Mann M, Ejsing CS, Krogan NJ, Walther TC. A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking. Nature Structural & Molecular Biology. 17: 901-8. PMID 20526336 DOI: 10.1038/nsmb.1829  0.52
2010 Aguilar PS, Heiman MG, Walther TC, Engel A, Schwudke D, Gushwa N, Kurzchalia T, Walter P. Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during mating. Proceedings of the National Academy of Sciences of the United States of America. 107: 4170-5. PMID 20150508 DOI: 10.1073/pnas.0914094107  0.52
2009 Krahmer N, Guo Y, Farese RV, Walther TC. SnapShot: Lipid Droplets Cell. 139. PMID 19945384 DOI: 10.1016/j.cell.2009.11.023  0.52
2009 Farese RV, Walther TC. Lipid Droplets Finally Get a Little R-E-S-P-E-C-T Cell. 139: 855-860. PMID 19945371 DOI: 10.1016/j.cell.2009.11.005  0.52
2009 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science (New York, N.Y.). 325: 834-40. PMID 19608861 DOI: 10.1126/science.1175371  0.52
2009 Fröhlich F, Moreira K, Aguilar PS, Hubner NC, Mann M, Walter P, Walther TC. A genome-wide screen for genes affecting eisosomes reveals Nce102 function in sphingolipid signaling. The Journal of Cell Biology. 185: 1227-42. PMID 19564405 DOI: 10.1083/jcb.200811081  0.52
2009 Guo Y, Cordes KR, Farese RV, Walther TC. Lipid droplets at a glance Journal of Cell Science. 122: 749-752. PMID 19261844 DOI: 10.1242/jcs.037630  0.52
2009 Stone SJ, Levin MC, Zhou P, Han J, Walther TC, Farese RV. The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria. The Journal of Biological Chemistry. 284: 5352-61. PMID 19049983 DOI: 10.1074/jbc.M805768200  0.52
2009 Walther TC, Farese RV. The life of lipid droplets Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids. 1791: 459-466. PMID 19041421 DOI: 10.1016/j.bbalip.2008.10.009  0.52
2009 Moreira KE, Walther TC, Aguilar PS, Walter P. Pil1 controls eisosome biogenesis. Molecular Biology of the Cell. 20: 809-18. PMID 19037108 DOI: 10.1091/mbc.E08-03-0313  0.52
2008 de Godoy LM, Olsen JV, Cox J, Nielsen ML, Hubner NC, Fröhlich F, Walther TC, Mann M. Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast. Nature. 455: 1251-4. PMID 18820680 DOI: 10.1038/nature07341  0.52
2008 Guo Y, Walther TC, Rao M, Stuurman N, Goshima G, Terayama K, Wong JS, Vale RD, Walter P, Farese RV. Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature. 453: 657-61. PMID 18408709 DOI: 10.1038/nature06928  0.52
2007 Walther TC, Aguilar PS, Fröhlich F, Chu F, Moreira K, Burlingame AL, Walter P. Pkh-kinases control eisosome assembly and organization. The Embo Journal. 26: 4946-55. PMID 18034155 DOI: 10.1038/sj.emboj.7601933  0.52
2006 Walther TC, Brickner JH, Aguilar PS, Bernales S, Pantoja C, Walter P. Eisosomes mark static sites of endocytosis. Nature. 439: 998-1003. PMID 16496001 DOI: 10.1038/nature04472  0.52
2002 Hinkle B, Slepchenko B, Rolls MM, Walther TC, Stein PA, Mehlmann LM, Ellenberg J, Terasaki M. Chromosomal association of Ran during meiotic and mitotic divisions. Journal of Cell Science. 115: 4685-93. PMID 12415012 DOI: 10.1242/jcs.00136  0.52
2002 Walther TC, Pickersgill HS, Cordes VC, Goldberg MW, Allen TD, Mattaj IW, Fornerod M. The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein import. The Journal of Cell Biology. 158: 63-77. PMID 12105182 DOI: 10.1083/jcb.200202088  0.52
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