Year |
Citation |
Score |
2023 |
Ho EK, Oatman HR, McFann SE, Yang L, Johnson HE, Shvartsman SY, Toettcher JE. Dynamics of an incoherent feedforward loop drive ERK-dependent pattern formation in the early Drosophila embryo. Development (Cambridge, England). PMID 37602510 DOI: 10.1242/dev.201818 |
0.362 |
|
2023 |
Underhill EJ, Toettcher JE. Control of gastruloid patterning and morphogenesis by the Erk and Akt signaling pathways. Development (Cambridge, England). 150. PMID 37590131 DOI: 10.1242/dev.201663 |
0.392 |
|
2023 |
McNamara HM, Solley SC, Adamson B, Chan MM, Toettcher JE. Recording morphogen signals reveals origins of gastruloid symmetry breaking. Biorxiv : the Preprint Server For Biology. PMID 37333235 DOI: 10.1101/2023.06.02.543474 |
0.379 |
|
2023 |
Farahani PE, Yang X, Mesev EV, Fomby KA, Brumbaugh-Reed EH, Bashor CJ, Nelson CM, Toettcher JE. pYtags enable spatiotemporal measurements of receptor tyrosine kinase signaling in living cells. Elife. 12. PMID 37212240 DOI: 10.7554/eLife.82863 |
0.717 |
|
2023 |
Ho EK, Oatman HR, McFann SE, Yang L, Johnson HE, Shvartsman SY, Toettcher JE. Dynamics of an incoherent feedforward loop drive ERK-dependent pattern formation in the early embryo. Biorxiv : the Preprint Server For Biology. PMID 36945584 DOI: 10.1101/2023.03.09.531972 |
0.381 |
|
2022 |
McFann SE, Shvartsman SY, Toettcher JE. Putting in the Erk: Growth factor signaling and mesoderm morphogenesis. Current Topics in Developmental Biology. 149: 263-310. PMID 35606058 DOI: 10.1016/bs.ctdb.2022.02.007 |
0.391 |
|
2022 |
McNamara HM, Ramm B, Toettcher JE. Synthetic developmental biology: New tools to deconstruct and rebuild developmental systems. Seminars in Cell & Developmental Biology. PMID 35484026 DOI: 10.1016/j.semcdb.2022.04.013 |
0.311 |
|
2021 |
Farahani PE, Lemke SB, Dine E, Uribe G, Toettcher JE, Nelson CM. Substratum stiffness regulates Erk signaling dynamics through receptor-level control. Cell Reports. 37: 110181. PMID 34965432 DOI: 10.1016/j.celrep.2021.110181 |
0.402 |
|
2021 |
Ravindran PT, McFann S, Thornton RH, Toettcher JE. A synthetic gene circuit for imaging-free detection of signaling pulses. Cell Systems. PMID 34739875 DOI: 10.1016/j.cels.2021.10.002 |
0.426 |
|
2021 |
Verma A, Jena SG, Isakov DR, Aoki K, Toettcher JE, Engelhardt BE. A self-exciting point process to study multicellular spatial signaling patterns. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34362843 DOI: 10.1073/pnas.2026123118 |
0.364 |
|
2021 |
Dine E, Reed EH, Toettcher JE. Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch. Cell Reports. 35: 109280. PMID 34161759 DOI: 10.1016/j.celrep.2021.109280 |
0.341 |
|
2021 |
McFann S, Dutta S, Toettcher JE, Shvartsman SY. Temporal integration of inductive cues on the way to gastrulation. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34083443 DOI: 10.1073/pnas.2102691118 |
0.365 |
|
2021 |
Zhao EM, Lalwani MA, Chen JM, Orillac P, Toettcher JE, Avalos JL. Optogenetic Amplification Circuits for Light-Induced Metabolic Control. Acs Synthetic Biology. PMID 33835777 DOI: 10.1021/acssynbio.0c00642 |
0.305 |
|
2021 |
Farahani PE, Reed EH, Underhill EJ, Aoki K, Toettcher JE. Signaling, Deconstructed: Using Optogenetics to Dissect and Direct Information Flow in Biological Systems. Annual Review of Biomedical Engineering. PMID 33722063 DOI: 10.1146/annurev-bioeng-083120-111648 |
0.383 |
|
2021 |
Lovelett RJ, Zhao EM, Lalwani MA, Toettcher JE, Kevrekidis IG, L Avalos J. Dynamical Modeling of Optogenetic Circuits in Yeast for Metabolic Engineering Applications. Acs Synthetic Biology. PMID 33492138 DOI: 10.1021/acssynbio.0c00372 |
0.301 |
|
2020 |
Ravindran PT, Wilson MZ, Jena SG, Toettcher JE. Engineering combinatorial and dynamic decoders using synthetic immediate-early genes. Communications Biology. 3: 436. PMID 32792645 DOI: 10.1038/s42003-020-01171-1 |
0.724 |
|
2020 |
Gil AA, Carrasco-López C, Zhu L, Zhao EM, Ravindran PT, Wilson MZ, Goglia AG, Avalos JL, Toettcher JE. Optogenetic control of protein binding using light-switchable nanobodies. Nature Communications. 11: 4044. PMID 32792536 DOI: 10.1038/S41467-020-17836-8 |
0.686 |
|
2020 |
Johnson HE, Djabrayan NJV, Shvartsman SY, Toettcher JE. Optogenetic Rescue of a Patterning Mutant. Current Biology : Cb. PMID 32707057 DOI: 10.1016/J.Cub.2020.06.059 |
0.333 |
|
2020 |
Goglia AG, Wilson MZ, Jena SG, Silbert J, Basta LP, Devenport D, Toettcher JE. A Live-Cell Screen for Altered Erk Dynamics Reveals Principles of Proliferative Control. Cell Systems. PMID 32191874 DOI: 10.1016/J.Cels.2020.02.005 |
0.719 |
|
2019 |
Zhao EM, Suek N, Wilson MZ, Dine E, Pannucci NL, Gitai Z, Avalos JL, Toettcher JE. Light-based control of metabolic flux through assembly of synthetic organelles. Nature Chemical Biology. PMID 31086330 DOI: 10.1038/S41589-019-0284-8 |
0.719 |
|
2019 |
Johnson HE, Toettcher JE. Signaling Dynamics Control Cell Fate in the Early Drosophila Embryo. Developmental Cell. 48: 361-370.e3. PMID 30753836 DOI: 10.1016/j.devcel.2019.01.009 |
0.416 |
|
2019 |
Goglia AG, Toettcher JE. A bright future: optogenetics to dissect the spatiotemporal control of cell behavior. Current Opinion in Chemical Biology. 48: 106-113. PMID 30529586 DOI: 10.1016/j.cbpa.2018.11.010 |
0.344 |
|
2018 |
Allard CAH, Decker F, Weiner OD, Toettcher JE, Graziano BR. A size-invariant bud-duration timer enables robustness in yeast cell size control. Plos One. 13: e0209301. PMID 30576342 DOI: 10.1371/Journal.Pone.0209301 |
0.72 |
|
2018 |
Bugaj LJ, Sabnis AJ, Mitchell A, Garbarino JE, Toettcher JE, Bivona TG, Lim WA. Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway. Science (New York, N.Y.). 361. PMID 30166458 DOI: 10.1126/Science.Aao3048 |
0.633 |
|
2017 |
Wilson MZ, Ravindran PT, Lim WA, Toettcher JE. Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control. Molecular Cell. PMID 28826673 DOI: 10.1016/J.Molcel.2017.07.016 |
0.765 |
|
2017 |
Goglia AG, Wilson MZ, DiGiorno DB, Toettcher JE. Optogenetic Control of Ras/Erk Signaling Using the Phy-PIF System. Methods in Molecular Biology (Clifton, N.J.). 1636: 3-20. PMID 28730469 DOI: 10.1007/978-1-4939-7154-1_1 |
0.74 |
|
2017 |
Johnson HE, Goyal Y, Pannucci NL, Schüpbach T, Shvartsman SY, Toettcher JE. The Spatiotemporal Limits of Developmental Erk Signaling. Developmental Cell. 40: 185-192. PMID 28118601 DOI: 10.1016/J.Mod.2017.04.131 |
0.462 |
|
2016 |
Gordley RM, Williams RE, Bashor CJ, Toettcher JE, Yan S, Lim WA. Engineering dynamical control of cell fate switching using synthetic phospho-regulons. Proceedings of the National Academy of Sciences of the United States of America. PMID 27821768 DOI: 10.1073/Pnas.1610973113 |
0.758 |
|
2016 |
Johnson HE, Toettcher JE. The Duty of an Intracellular Signal: Illuminating Calcium's Role in Transcriptional Control. Cell Systems. 2: 223-4. PMID 27135534 DOI: 10.1016/j.cels.2016.04.007 |
0.321 |
|
2016 |
Hoeller O, Toettcher JE, Cai H, Sun Y, Huang CH, Freyre M, Zhao M, Devreotes PN, Weiner OD. Gβ Regulates Coupling between Actin Oscillators for Cell Polarity and Directional Migration. Plos Biology. 14: e1002381. PMID 26890004 DOI: 10.1371/Journal.Pbio.1002381 |
0.593 |
|
2016 |
Johnson HE, Toettcher JE. The Duty of an Intracellular Signal: Illuminating Calcium's Role in Transcriptional Control Cell Systems. 2: 223-224. DOI: 10.1016/j.cels.2016.04.007 |
0.317 |
|
2013 |
Toettcher JE, Weiner OD, Lim WA. Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module. Cell. 155: 1422-34. PMID 24315106 DOI: 10.1016/J.Cell.2013.11.004 |
0.739 |
|
2012 |
Toettcher J, Gong D, Lim WA, Weiner O. A Light-Based Feedback Control System for Generating User-Defined Intracelullar Signaling Dynamics Biophysical Journal. 102: 41a. DOI: 10.1016/J.Bpj.2011.11.253 |
0.768 |
|
2011 |
Toettcher JE, Gong D, Lim WA, Weiner OD. Light-based feedback for controlling intracellular signaling dynamics. Nature Methods. 8: 837-9. PMID 21909100 DOI: 10.1038/Nmeth.1700 |
0.777 |
|
2011 |
Toettcher JE, Gong D, Lim WA, Weiner OD. Light control of plasma membrane recruitment using the Phy-PIF system. Methods in Enzymology. 497: 409-23. PMID 21601096 DOI: 10.1016/B978-0-12-385075-1.00017-2 |
0.736 |
|
2011 |
Toettcher JE, Voigt CA, Weiner OD, Lim WA. The promise of optogenetics in cell biology: interrogating molecular circuits in space and time. Nature Methods. 8: 35-8. PMID 21191370 DOI: 10.1038/Nmeth.F.326 |
0.701 |
|
2010 |
Toettcher JE, Mock C, Batchelor E, Loewer A, Lahav G. A synthetic-natural hybrid oscillator in human cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 17047-52. PMID 20837528 DOI: 10.1073/Pnas.1005615107 |
0.375 |
|
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