Harinder Singh - Publications

Affiliations: 
1989-2009 University of Chicago, Chicago, IL 
 2019- University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Immunology
Website:
https://alleninstitute.org/about/advisors/advisor-profiles/harinder-singh/

72 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Cillo AR, Somasundaram A, Shan F, Cardello C, Workman CJ, Kitsios GD, Ruffin A, Kunning S, Lampenfeld C, Onkar S, Grebinoski S, Deshmukh G, Methe B, Liu C, Nambulli S, ... ... Singh H, et al. Bifurcated monocyte states are predictive of mortality in severe COVID-19. Biorxiv : the Preprint Server For Biology. PMID 33594364 DOI: 10.1101/2021.02.10.430499  1
2018 Karki S, Kennedy DE, Mclean K, Grzybowski AT, Maienschein-Cline M, Banerjee S, Xu H, Davis E, Mandal M, Labno C, Powers SE, Le Beau MM, Dinner AR, Singh H, Ruthenburg AJ, et al. Regulated Capture of Vκ Gene Topologically Associating Domains by Transcription Factories. Cell Reports. 24: 2443-2456. PMID 30157436 DOI: 10.1016/J.Celrep.2018.07.091  1
2016 Olsson A, Venkatasubramanian M, Chaudhri VK, Aronow BJ, Salomonis N, Singh H, Grimes HL. Single-cell analysis of mixed-lineage states leading to a binary cell fate choice. Nature. PMID 27580035 DOI: 10.1038/Nature19348  1
2015 Xu H, Chaudhri VK, Wu Z, Biliouris K, Dienger-Stambaugh K, Rochman Y, Singh H. Regulation of bifurcating B cell trajectories by mutual antagonism between transcription factors IRF4 and IRF8. Nature Immunology. PMID 26437243 DOI: 10.1038/Ni.3287  1
2014 Singh H. Transcriptional and epigenetic networks orchestrating immune cell development and function. Immunological Reviews. 261: 5-8. PMID 25123273 DOI: 10.1111/Imr.12210  1
2014 Singh H, Khan AA, Dinner AR. Gene regulatory networks in the immune system. Trends in Immunology. 35: 211-8. PMID 24768519 DOI: 10.1016/J.It.2014.03.006  1
2014 Clark MR, Mandal M, Ochiai K, Singh H. Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling. Nature Reviews. Immunology. 14: 69-80. PMID 24378843 DOI: 10.1038/Nri3570  1
2014 Vander Lugt B, Khan AA, Hackney JA, Agrawal S, Lesch J, Zhou M, Lee WP, Park S, Xu M, DeVoss J, Spooner CJ, Chalouni C, Delamarre L, Mellman I, Singh H. Transcriptional programming of dendritic cells for enhanced MHC class II antigen presentation. Nature Immunology. 15: 161-7. PMID 24362890 DOI: 10.1038/Ni.2795  1
2013 Singh H, Glasmacher E, Chang AB, Vander Lugt B. The molecular choreography of IRF4 and IRF8 with immune system partners. Cold Spring Harbor Symposia On Quantitative Biology. 78: 101-4. PMID 24752218 DOI: 10.1101/Sqb.2013.78.020305  1
2013 Williams JW, Tjota MY, Clay BS, Vander Lugt B, Bandukwala HS, Hrusch CL, Decker DC, Blaine KM, Fixsen BR, Singh H, Sciammas R, Sperling AI. Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation. Nature Communications. 4: 2990. PMID 24356538 DOI: 10.1038/Ncomms3990  1
2013 Spooner CJ, Lesch J, Yan D, Khan AA, Abbas A, Ramirez-Carrozzi V, Zhou M, Soriano R, Eastham-Anderson J, Diehl L, Lee WP, Modrusan Z, Pappu R, Xu M, DeVoss J, ... Singh H, et al. Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1. Nature Immunology. 14: 1229-36. PMID 24141388 DOI: 10.1038/Ni.2743  1
2013 Ochiai K, Maienschein-Cline M, Simonetti G, Chen J, Rosenthal R, Brink R, Chong AS, Klein U, Dinner AR, Singh H, Sciammas R. Transcriptional regulation of germinal center B and plasma cell fates by dynamical control of IRF4. Immunity. 38: 918-29. PMID 23684984 DOI: 10.1016/J.Immuni.2013.04.009  1
2012 Tussiwand R, Lee WL, Murphy TL, Mashayekhi M, KC W, Albring JC, Satpathy AT, Rotondo JA, Edelson BT, Kretzer NM, Wu X, Weiss LA, Glasmacher E, Li P, Liao W, ... ... Singh H, et al. Compensatory dendritic cell development mediated by BATF-IRF interactions. Nature. 490: 502-7. PMID 22992524 DOI: 10.1038/Nature11531  1
2012 Glasmacher E, Agrawal S, Chang AB, Murphy TL, Zeng W, Vander Lugt B, Khan AA, Ciofani M, Spooner CJ, Rutz S, Hackney J, Nurieva R, Escalante CR, Ouyang W, Littman DR, ... ... Singh H, et al. A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science (New York, N.Y.). 338: 975-80. PMID 22983707 DOI: 10.1126/Science.1228309  1
2012 Zullo JM, Demarco IA, Piqué-Regi R, Gaffney DJ, Epstein CB, Spooner CJ, Luperchio TR, Bernstein BE, Pritchard JK, Reddy KL, Singh H. DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina. Cell. 149: 1474-87. PMID 22726435 DOI: 10.1016/J.Cell.2012.04.035  1
2012 Seiler MP, Mathew R, Liszewski MK, Spooner CJ, Spooner C, Barr K, Meng F, Singh H, Bendelac A. Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling. Nature Immunology. 13: 264-71. PMID 22306690 DOI: 10.1038/Ni.2230  1
2012 Ochiai K, Maienschein-Cline M, Mandal M, Triggs JR, Bertolino E, Sciammas R, Dinner AR, Clark MR, Singh H. A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation. Nature Immunology. 13: 300-7. PMID 22267219 DOI: 10.1038/Ni.2210  1
2012 Becker AM, Michael DG, Satpathy AT, Sciammas R, Singh H, Bhattacharya D. IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors. Blood. 119: 2003-12. PMID 22238324 DOI: 10.1182/Blood-2011-06-364976  1
2011 Sciammas R, Li Y, Warmflash A, Song Y, Dinner AR, Singh H. An incoherent regulatory network architecture that orchestrates B cell diversification in response to antigen signaling. Molecular Systems Biology. 7: 495. PMID 21613984 DOI: 10.1038/Msb.2011.25  1
2010 Mewborn SK, Puckelwartz MJ, Abuisneineh F, Fahrenbach JP, Zhang Y, MacLeod H, Dellefave L, Pytel P, Selig S, Labno CM, Reddy K, Singh H, McNally E. Altered chromosomal positioning, compaction, and gene expression with a lamin A/C gene mutation. Plos One. 5: e14342. PMID 21179469 DOI: 10.1371/Journal.Pone.0014342  1
2010 Jo SH, Schatz JH, Acquaviva J, Singh H, Ren R. Cooperation between deficiencies of IRF-4 and IRF-8 promotes both myeloid and lymphoid tumorigenesis. Blood. 116: 2759-67. PMID 20585039 DOI: 10.1182/Blood-2009-07-234559  1
2010 Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, Cheng JX, Murre C, Singh H, Glass CK. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Molecular Cell. 38: 576-89. PMID 20513432 DOI: 10.1016/J.Molcel.2010.05.004  1
2010 Hu Z, Negrotto S, Gu X, Mahfouz R, Ng KP, Ebrahem Q, Copelan E, Singh H, Maciejewski JP, Saunthararajah Y. Decitabine maintains hematopoietic precursor self-renewal by preventing repression of stem cell genes by a differentiation-inducing stimulus. Molecular Cancer Therapeutics. 9: 1536-43. PMID 20501800 DOI: 10.1158/1535-7163.Mct-10-0191  1
2009 Mandal M, Powers SE, Ochiai K, Georgopoulos K, Kee BL, Singh H, Clark MR. Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development. Nature Immunology. 10: 1110-7. PMID 19734904 DOI: 10.1038/Ni.1785  1
2009 Johnson K, Reddy KL, Singh H. Molecular pathways and mechanisms regulating the recombination of immunoglobulin genes during B-lymphocyte development. Advances in Experimental Medicine and Biology. 650: 133-47. PMID 19731807 DOI: 10.1007/978-1-4419-0296-2_11  1
2009 Singh H. Teeing up transcription on CpG islands. Cell. 138: 14-6. PMID 19596228 DOI: 10.1016/J.Cell.2009.06.028  1
2008 Reynaud D, Demarco IA, Reddy KL, Schjerven H, Bertolino E, Chen Z, Smale ST, Winandy S, Singh H. Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros. Nature Immunology. 9: 927-36. PMID 18568028 DOI: 10.1038/Ni.1626  1
2008 Schlimgen RJ, Reddy KL, Singh H, Krangel MS. Initiation of allelic exclusion by stochastic interaction of Tcrb alleles with repressive nuclear compartments. Nature Immunology. 9: 802-9. PMID 18536719 DOI: 10.1038/Ni.1624  1
2008 Johnson K, Hashimshony T, Sawai CM, Pongubala JM, Skok JA, Aifantis I, Singh H. Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling. Immunity. 28: 335-45. PMID 18280186 DOI: 10.1016/J.Immuni.2007.12.019  1
2008 Reddy KL, Zullo JM, Bertolino E, Singh H. Transcriptional repression mediated by repositioning of genes to the nuclear lamina. Nature. 452: 243-7. PMID 18272965 DOI: 10.1038/Nature06727  1
2008 Pongubala JM, Northrup DL, Lancki DW, Medina KL, Treiber T, Bertolino E, Thomas M, Grosschedl R, Allman D, Singh H. Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5. Nature Immunology. 9: 203-15. PMID 18176567 DOI: 10.1038/Ni1555  1
2007 Littman DR, Singh H. Immunology. Asymmetry and immune memory. Science (New York, N.Y.). 315: 1673-4. PMID 17379796 DOI: 10.1126/Science.1141184  1
2007 Singh H, Pongubala JM, Medina KL. Gene regulatory networks that orchestrate the development of B lymphocyte precursors. Advances in Experimental Medicine and Biology. 596: 57-62. PMID 17338175 DOI: 10.1007/0-387-46530-8_5  1
2007 Singh H. Shaping a helper T cell identity Nature Immunology. 8: 119-120. PMID 17242680 DOI: 10.1038/Ni0207-119  1
2006 Laslo P, Spooner CJ, Warmflash A, Lancki DW, Lee HJ, Sciammas R, Gantner BN, Dinner AR, Singh H. Multilineage transcriptional priming and determination of alternate hematopoietic cell fates. Cell. 126: 755-66. PMID 16923394 DOI: 10.1016/J.Cell.2006.06.052  1
2006 Sciammas R, Shaffer AL, Schatz JH, Zhao H, Staudt LM, Singh H. Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Immunity. 25: 225-36. PMID 16919487 DOI: 10.1016/J.Immuni.2006.07.009  1
2005 Medina KL, Singh H. Gene regulatory networks orchestrating B cell fate specification, commitment, and differentiation. Current Topics in Microbiology and Immunology. 290: 1-14. PMID 16480036 DOI: 10.1007/3-540-26363-2_1  1
2005 Bertolino E, Reddy K, Medina KL, Parganas E, Ihle J, Singh H. Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5. Nature Immunology. 6: 836-43. PMID 16025120 DOI: 10.1038/Ni1226  1
2005 Medina KL, Singh H. Genetic networks that regulate B lymphopoiesis. Current Opinion in Hematology. 12: 203-9. PMID 15867576 DOI: 10.1097/01.Moh.0000160735.67596.A0  1
2005 Singh H, Medina KL, Pongubala JM. Contingent gene regulatory networks and B cell fate specification. Proceedings of the National Academy of Sciences of the United States of America. 102: 4949-53. PMID 15788530 DOI: 10.1073/Pnas.0500480102  1
2004 Medina KL, Pongubala JM, Reddy KL, Lancki DW, Dekoter R, Kieslinger M, Grosschedl R, Singh H. Assembling a gene regulatory network for specification of the B cell fate. Developmental Cell. 7: 607-17. PMID 15469848 DOI: 10.1016/J.Devcel.2004.08.006  1
2004 Maier H, Ostraat R, Gao H, Fields S, Shinton SA, Medina KL, Ikawa T, Murre C, Singh H, Hardy RR, Hagman J. Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription. Nature Immunology. 5: 1069-77. PMID 15361869 DOI: 10.1038/Ni1119  1
2003 Dahl R, Walsh JC, Lancki D, Laslo P, Iyer SR, Singh H, Simon MC. Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPalpha ratio and granulocyte colony-stimulating factor. Nature Immunology. 4: 1029-36. PMID 12958595 DOI: 10.1038/Ni973  1
2003 Lu R, Medina KL, Lancki DW, Singh H. IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte development. Genes & Development. 17: 1703-8. PMID 12832394 DOI: 10.1101/Gad.1104803  1
2002 Walsh JC, DeKoter RP, Lee HJ, Smith ED, Lancki DW, Gurish MF, Friend DS, Stevens RL, Anastasi J, Singh H. Cooperative and antagonistic interplay between PU.1 and GATA-2 in the specification of myeloid cell fates. Immunity. 17: 665-76. PMID 12433372 DOI: 10.1016/S1074-7613(02)00452-1  1
2002 Escalante CR, Shen L, Escalante MC, Brass AL, Edwards TA, Singh H, Aggarwal AK. Crystallization and characterization of PU.1/IRF-4/DNA ternary complex. Journal of Structural Biology. 139: 55-9. PMID 12372320 DOI: 10.1016/S1047-8477(02)00514-2  1
2002 Bertolino E, Singh H. POU/TBP Cooperativity: A Mechanism for Enhancer Action from a Distance Molecular Cell. 10: 397-407. PMID 12191484 DOI: 10.1016/S1097-2765(02)00597-X  1
2002 Rengarajan J, Mowen KA, McBride KD, Smith ED, Singh H, Glimcher LH. Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression. The Journal of Experimental Medicine. 195: 1003-12. PMID 11956291 DOI: 10.1084/Jem.20011128  1
2002 Kosak ST, Skok JA, Medina KL, Riblet R, Le Beau MM, Fisher AG, Singh H. Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development. Science (New York, N.Y.). 296: 158-62. PMID 11935030 DOI: 10.1126/Science.1068768  1
2001 Singh H. Detection, purification, and characterization of cDNA clones encoding DNA-binding proteins Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [Et Al.]. PMID 18265090 DOI: 10.1002/0471142727.Mb1207S13  1
1999 Glimcher LH, Singh H. Transcription factors in lymphocyte development - T and B cells get together Cell. 96: 13-23. PMID 9989493 DOI: 10.1016/S0092-8674(00)80955-1  1
1997 Shah PC, Bertolino E, Singh H. Using altered specificity Oct-1 and Oct-2 mutants to analyze the regulation of immunoglobulin gene transcription. The Embo Journal. 16: 7105-7117. PMID 9384588 DOI: 10.1093/Emboj/16.23.7105  1
1996 Singh H. Gene targeting reveals a hierarchy of transcription factors regulating specification of lymphoid cell fates Current Opinion in Immunology. 8: 160-165. PMID 8725938 DOI: 10.1016/S0952-7915(96)80053-7  1
1996 Simon MC, Olson M, Scott E, Hack A, Su G, Singh H. Terminal myeloid gene expression and differentiation requires the transcription factor PU.1. Current Topics in Microbiology and Immunology. 211: 113-9. PMID 8585941 DOI: 10.1007/978-3-642-85232-9_11  1
1995 Olson MC, Scott EW, Hack AA, Su GH, Tenen DG, Singh H, Simon MC. PU. 1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation. Immunity. 3: 703-14. PMID 8777716 DOI: 10.1016/1074-7613(95)90060-8  1
1994 Scott EW, Simon MC, Anastasi J, Singh H. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages Science. 265: 1573-1577. PMID 8079170 DOI: 10.1126/Science.8079170  1
1994 Klug CA, Gerety SJ, Shah PC, Chen YY, Rice NR, Rosenberg N, Singh H. The v-abl tyrosine kinase negatively regulates NF-κB/Rel factors and blocks κ gene transcription in pre-B lymphocytes Genes and Development. 8: 678-687. PMID 7926758 DOI: 10.1101/Gad.8.6.678  1
1994 Singh H. Genetic analysis of transcription factors implicated in B lymphocyte development Immunologic Research. 13: 280-290. PMID 7616055 DOI: 10.1007/Bf02935619  1
1993 Singh H. Specific recognition site probes for isolating genes encoding DNA-binding proteins Methods in Enzymology. 218: 551-567. PMID 8510547 DOI: 10.1016/0076-6879(93)18041-A  1
1993 Feldhaus AL, Klug CA, Arvin KL, Singh H. Targeted disruption of the Oct-2 locus in a B cell provides genetic evidence for two distinct cell type-specific pathways of octamer element-mediated gene activation Embo Journal. 12: 2763-2772. PMID 8334992 DOI: 10.1002/J.1460-2075.1993.Tb05937.X  1
1992 Feldhaus AL, Mbangkollo D, Arvin KL, Klug CA, Singh H. BLyF, a Novel Cell-Type- and Stage-Specific Regulator of the B-Lymphocyte Gene mb-1 Molecular and Cellular Biology. 12: 1126-1133. PMID 1545794 DOI: 10.1128/Mcb.12.3.1126  1
1991 Miller CL, Feldhaus AL, Rooney JW, Rhodes LD, Sibley CH, Singh H. Regulation and a possible stage-specific function of Oct-2 during pre-B-cell differentiation. Molecular and Cellular Biology. 11: 4885-94. PMID 1922024 DOI: 10.1128/Mcb.11.10.4885  1
1991 Zhang Y, Babin J, Feldhaus AL, Singh H, Sharp PA, Bina M. HTF4: a new human helix-loop-helix protein. Nucleic Acids Research. 19: 4555. PMID 1886779 DOI: 10.1093/Nar/19.16.4555  1
1990 Baldwin AS, LeClair KP, Singh H, Sharp PA. A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes. Molecular and Cellular Biology. 10: 1406-14. PMID 2108316 DOI: 10.1128/Mcb.10.4.1406  1
1990 Singh H. Molecular cloning of genes encoding transcription factors with the use of recognition site probes Genetic Engineering. 12: 317-330. PMID 1366707 DOI: 10.1007/978-1-4613-0641-2_16  1
1988 Staudt LM, Clerc RG, Singh H, LeBowitz JH, Sharp PA, Baltimore D. Cloning of a lymphoid-specific cDNA encoding a protein binding the regulatory octamer DNA motif Science. 241: 577-580. PMID 3399892 DOI: 10.1126/Science.3399892  1
1988 Singh H, LeBowitz JH, Baldwin AS, Sharp PA. Molecular cloning of an enhancer binding protein: isolation by screening of an expression library with a recognition site DNA. Cell. 52: 415-23. PMID 2964277 DOI: 10.1016/S0092-8674(88)80034-5  1
1986 Staudt LM, Singh H, Sen R, Wirth T, Sharp PA, Baltimore D. A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes. Nature. 323: 640-3. PMID 3095662 DOI: 10.1038/323640A0  1
1986 Singh H, Sen R, Baltimore D, Sharp PA. A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes. Nature. 319: 154-8. PMID 3079885 DOI: 10.1038/319154A0  1
1986 Singh H, Brooke RG, Pausch MH, Williams GT, Trainor C, Dumas LB. Yeast DNA primase and DNA polymerase activities. An analysis of RNA priming and its coupling to DNA synthesis. The Journal of Biological Chemistry. 261: 8564-9. PMID 2424899  1
1984 Singh H, Dumas LB. A DNA primase that copurifies with the major DNA polymerase from the yeast Saccharomyces cerevisiae. The Journal of Biological Chemistry. 259: 7936-40. PMID 6376495  1
1982 Singh H, Bieker JJ, Dumas LB. Genetic transformation of Saccharomyces cerevisiae with single-stranded circular DNA vectors. Gene. 20: 441-9. PMID 6299901 DOI: 10.1016/0378-1119(82)90213-X  1
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