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Jerome Mertens - Publications

Affiliations: 
University of Innsbruck, Innsbruck, Tirol, Austria 
Area:
induced neurons, Alzheimer's Disease, aging, neurodegeneration, iPSCs, neural stem cells, reprogramming
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45 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Castillo Bautista CM, Eismann K, Gentzel M, Pelucchi S, Mertens J, Walters HE, Yun MH, Sterneckert J. Obatoclax Rescues FUS-ALS Phenotypes in iPSC-Derived Neurons by Inducing Autophagy. Cells. 12. PMID 37759469 DOI: 10.3390/cells12182247  0.389
2023 Traxler L, Lucciola R, Herdy JR, Jones JR, Mertens J, Gage FH. Neural cell state shifts and fate loss in ageing and age-related diseases. Nature Reviews. Neurology. PMID 37268723 DOI: 10.1038/s41582-023-00815-0  0.495
2022 Herdy JR, Traxler L, Agarwal RK, Karbacher L, Schlachetzki JCM, Boehnke L, Zangwill D, Galasko D, Glass CK, Mertens J, Gage FH. Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer's disease. Cell Stem Cell. 29: 1637-1652.e6. PMID 36459967 DOI: 10.1016/j.stem.2022.11.010  0.609
2022 van den Hurk M, Lau S, Marchetto MC, Mertens J, Stern S, Corti O, Brice A, Winner B, Winkler J, Gage FH, Bardy C. Druggable transcriptomic pathways revealed in Parkinson's patient-derived midbrain neurons. Npj Parkinson's Disease. 8: 134. PMID 36258029 DOI: 10.1038/s41531-022-00400-0  0.487
2022 Traxler L, Herdy JR, Stefanoni D, Eichhorner S, Pelucchi S, Szücs A, Santagostino A, Kim Y, Agarwal RK, Schlachetzki JCM, Glass CK, Lagerwall J, Galasko D, Gage FH, D'Alessandro A, ... Mertens J, et al. Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer's disease. Cell Metabolism. PMID 35987203 DOI: 10.1016/j.cmet.2022.07.014  0.522
2022 Böhnke L, Zhou-Yang L, Pelucchi S, Kogler F, Frantal D, Schön F, Lagerström S, Borgogno O, Baltazar J, Herdy JR, Kittel-Schneider S, Defrancesco M, Mertens J. Chemical Replacement of Noggin with Dorsomorphin Homolog 1 for Cost-Effective Direct Neuronal Conversion. Cellular Reprogramming. PMID 35877103 DOI: 10.1089/cell.2021.0200  0.46
2021 Soni A, Klütsch D, Hu X, Houtman J, Rund N, McCloskey A, Mertens J, Schafer ST, Amin H, Toda T. Improved Method for Efficient Generation of Functional Neurons from Murine Neural Progenitor Cells. Cells. 10. PMID 34440662 DOI: 10.3390/cells10081894  0.489
2021 Zhou-Yang L, Eichhorner S, Karbacher L, Böhnke L, Traxler L, Mertens J. Direct Conversion of Human Fibroblasts to Induced Neurons. Methods in Molecular Biology (Clifton, N.J.). 2352: 73-96. PMID 34324181 DOI: 10.1007/978-1-0716-1601-7_6  0.385
2021 Mertens J, Herdy JR, Traxler L, Schafer ST, Schlachetzki JCM, Böhnke L, Reid DA, Lee H, Zangwill D, Fernandes DP, Agarwal RK, Lucciola R, Zhou-Yang L, Karbacher L, Edenhofer F, et al. Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients. Cell Stem Cell. PMID 33910058 DOI: 10.1016/j.stem.2021.04.004  0.613
2021 Herdy JR, Karbacher L, Mertens J. One Big Step to a Neuron, Two Small Steps for miRNAs. Cell Stem Cell. 28: 1-2. PMID 33417865 DOI: 10.1016/j.stem.2020.12.007  0.353
2020 Schlachetzki JCM, Toda T, Mertens J. When function follows form: Nuclear compartment structure and the epigenetic landscape of the aging neuron. Experimental Gerontology. 133: 110876. PMID 32068088 DOI: 10.1016/J.Exger.2020.110876  0.514
2019 Traxler L, Edenhofer F, Mertens J. Next-generation disease modeling with direct conversion: a new path to old neurons. Febs Letters. 593: 3316-3337. PMID 31715002 DOI: 10.1002/1873-3468.13678  0.504
2019 Erharter A, Rizzi S, Mertens J, Edenhofer F. Take the shortcut - direct conversion of somatic cells into induced neural stem cells and their biomedical applications. Febs Letters. 593: 3353-3369. PMID 31663609 DOI: 10.1002/1873-3468.13656  0.377
2019 Herdy J, Schafer S, Kim Y, Ansari Z, Zangwill D, Ku M, Paquola A, Lee H, Mertens J, Gage FH. Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons. Elife. 8. PMID 31099332 DOI: 10.7554/Elife.41356  0.56
2019 Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, ... ... Mertens J, et al. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 101: 349. PMID 30653936 DOI: 10.1016/J.Neuron.2018.12.031  0.404
2019 Schafer ST, Paquola ACM, Stern S, Gosselin D, Ku M, Pena M, Kuret TJM, Liyanage M, Mansour AA, Jaeger BN, Marchetto MC, Glass CK, Mertens J, Gage FH. Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons. Nature Neuroscience. PMID 30617258 DOI: 10.1038/S41593-018-0295-X  0.548
2019 Herdy J, Schafer S, Kim Y, Ansari Z, Zangwill D, Ku M, Paquola A, Lee H, Mertens J, Gage FH. Author response: Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons Elife. DOI: 10.7554/Elife.41356.036  0.427
2018 Böhnke L, Traxler L, Herdy JR, Mertens J. Human neurons to model aging: A dish best served old. Drug Discovery Today. Disease Models. 27: 43-49. PMID 31745399 DOI: 10.1016/J.Ddmod.2019.01.001  0.436
2018 Mertens J, Reid D, Lau S, Kim Y, Gage FH. Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases. Annual Review of Genetics. PMID 30208291 DOI: 10.1146/Annurev-Genet-120417-031534  0.563
2018 Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburgh CR, ... ... Mertens J, et al. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 99: 925-940.e7. PMID 30189209 DOI: 10.1016/J.Neuron.2018.07.039  0.468
2018 Kim Y, Zheng X, Ansari Z, Bunnell MC, Herdy JR, Traxler L, Lee H, Paquola ACM, Blithikioti C, Ku M, Schlachetzki JCM, Winkler J, Edenhofer F, Glass CK, Paucar AA, ... ... Mertens J, et al. Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile. Cell Reports. 23: 2550-2558. PMID 29847787 DOI: 10.1016/J.Celrep.2018.04.105  0.53
2017 Toda T, Hsu JY, Linker SB, Hu L, Schafer ST, Mertens J, Jacinto FV, Hetzer MW, Gage FH. Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells. Cell Stem Cell. PMID 28919367 DOI: 10.1016/J.Stem.2017.08.012  0.48
2017 Kelsoe J, McCarthy M, Nievergelt C, Shilling P, Nurnberger J, Gershon E, Coryell W, McInnis M, Berrettini W, Odegaard K, Calabrese J, Zandi P, Alda M, Frye M, Craig D, ... Mertens J, et al. 705. Using iPS Derived Neurons and GWAS Together to Identify Genes for Lithium Response Biological Psychiatry. 81: S285-S286. DOI: 10.1016/J.Biopsych.2017.02.772  0.711
2016 Vadodaria KC, Marchetto MC, Mertens J, Gage FH. Generating human serotonergic neurons in vitro: Methodological advances. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. PMID 27716980 DOI: 10.1002/Bies.201600127  0.764
2016 Zheng X, Boyer L, Jin M, Mertens J, Kim Y, Ma L, Ma L, Hamm M, Gage FH, Hunter T. Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation. Elife. 5. PMID 27282387 DOI: 10.7554/Elife.13374  0.61
2016 Mertens J, Marchetto MC, Bardy C, Gage FH. Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience. Nature Reviews. Neuroscience. PMID 27194476 DOI: 10.1038/Nrn.2016.46  0.562
2016 Oedegaard KJ, Alda M, Anand A, Andreassen OA, Balaraman Y, Berrettini WH, Bhattacharjee A, Brennand KJ, Burdick KE, Calabrese JR, Calkin CV, Claasen A, Coryell WH, Craig D, DeModena A, ... ... Mertens J, et al. The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample. Bmc Psychiatry. 16: 129. PMID 27150464 DOI: 10.1186/S12888-016-0732-X  0.638
2016 Vadodaria KC, Mertens J, Paquola A, Bardy C, Li X, Jappelli R, Fung L, Marchetto MC, Hamm M, Gorris M, Koch P, Gage FH. The different moods of human serotonergic neurons. Molecular Psychiatry. 21: 3. PMID 26678308 DOI: 10.1038/Mp.2015.202  0.762
2016 Zheng X, Boyer L, Jin M, Mertens J, Kim Y, Ma L, Hamm M, Gage FH, Hunter T. Author response: Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation Elife. DOI: 10.7554/Elife.13374.034  0.515
2015 Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames T, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, et al. Erratum: Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature. PMID 26605530 DOI: 10.1038/Nature16182  0.727
2015 Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames T, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, et al. Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature. PMID 26524527 DOI: 10.1038/Nature15526  0.708
2015 Vadodaria KC, Mertens J, Paquola A, Bardy C, Li X, Jappelli R, Fung L, Marchetto MC, Hamm M, Gorris M, Koch P, Gage FH. Generation of functional human serotonergic neurons from fibroblasts. Molecular Psychiatry. PMID 26503761 DOI: 10.1038/Mp.2015.161  0.774
2015 Mertens J, Paquola AC, Ku M, Hatch E, Böhnke L, Ladjevardi S, McGrath S, Campbell B, Lee H, Herdy JR, Gonçalves JT, Toda T, Kim Y, Winkler J, Yao J, et al. Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. Cell Stem Cell. PMID 26456686 DOI: 10.1016/J.Stem.2015.09.001  0.641
2015 Jovičić A, Mertens J, Boeynaems S, Bogaert E, Chai N, Yamada SB, Paul JW, Sun S, Herdy JR, Bieri G, Kramer NJ, Gage FH, Van Den Bosch L, Robberecht W, Gitler AD. Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS. Nature Neuroscience. 18: 1226-9. PMID 26308983 DOI: 10.1038/Nn.4085  0.43
2015 Mitschka S, Ulas T, Goller T, Schneider K, Egert A, Mertens J, Brüstle O, Schorle H, Beyer M, Klee K, Xue J, Günther P, Bassler K, Schultze JL, Kolanus W. Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71. Scientific Reports. 5: 11126. PMID 26057209 DOI: 10.1038/Srep11126  0.319
2015 Bardy C, van den Hurk M, Eames T, Marchand C, Hernandez RV, Kellogg M, Gorris M, Galet B, Palomares V, Brown J, Bang AG, Mertens J, Böhnke L, Boyer L, Simon S, et al. Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro. Proceedings of the National Academy of Sciences of the United States of America. 112: E2725-34. PMID 25870293 DOI: 10.1073/Pnas.1504393112  0.649
2015 Adamowicz DH, Mertens J, Gage FH. Alzheimer's disease: distinct stages in neurogenic decline? Biological Psychiatry. 77: 680-2. PMID 25835286 DOI: 10.1016/J.Biopsych.2015.02.021  0.518
2015 Bardy C, Van Den Hurk M, Eames T, Marchand C, Hernandez RV, Kellogg M, Gorris M, Galet B, Palomares V, Brown J, Bang AG, Mertens J, Böhnke L, Boyer L, Simon S, et al. Correction: Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro (Proceedings of the National Academy of Sciences of the United States of America (2015) 112 (E2725-E2734) DOI: 10.1073/pnas.1504393112) Proceedings of the National Academy of Sciences of the United States of America. 112: E3312. DOI: 10.1073/Pnas.1509741112  0.469
2015 Jovičič A, Mertens J, Boeynaems S, Bogaert E, Chai N, Yamada SB, Paul JW, Sun S, Herdy JR, Bieri G, Kramer NJ, Gage FH, Van Den Bosch L, Robberecht W, Gitler AD. Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS Nature Neuroscience. 18: 1226-1229. DOI: 10.1038/nn.4085  0.3
2013 Mertens J, Stüber K, Wunderlich P, Ladewig J, Kesavan JC, Vandenberghe R, Vandenbulcke M, van Damme P, Walter J, Brüstle O, Koch P. APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based γ-secretase modulation. Stem Cell Reports. 1: 491-8. PMID 24371804 DOI: 10.1016/J.Stemcr.2013.10.011  0.533
2013 Mertens J, Stüber K, Poppe D, Doerr J, Ladewig J, Brüstle O, Koch P. Embryonic stem cell-based modeling of tau pathology in human neurons. The American Journal of Pathology. 182: 1769-79. PMID 23499461 DOI: 10.1016/J.Ajpath.2013.01.043  0.53
2013 Glas M, Coch C, Trageser D, Dassler J, Simon M, Koch P, Mertens J, Quandel T, Gorris R, Reinartz R, Wieland A, Von Lehe M, Pusch A, Roy K, Schlee M, et al. Targeting the cytosolic innate immune receptors RIG-I and MDA5 effectively counteracts cancer cell heterogeneity in glioblastoma. Stem Cells (Dayton, Ohio). 31: 1064-74. PMID 23390110 DOI: 10.1002/Stem.1350  0.314
2012 Koch P, Tamboli IY, Mertens J, Wunderlich P, Ladewig J, Stüber K, Esselmann H, Wiltfang J, Brüstle O, Walter J. Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of γ-secretase activity in endogenous amyloid-β generation. The American Journal of Pathology. 180: 2404-16. PMID 22510327 DOI: 10.1016/J.Ajpath.2012.02.012  0.529
2012 Ladewig J, Mertens J, Kesavan J, Doerr J, Poppe D, Glaue F, Herms S, Wernet P, Kögler G, Müller FJ, Koch P, Brüstle O. Small molecules enable highly efficient neuronal conversion of human fibroblasts. Nature Methods. 9: 575-8. PMID 22484851 DOI: 10.1038/Nmeth.1972  0.555
2011 Koch P, Breuer P, Peitz M, Jungverdorben J, Kesavan J, Poppe D, Doerr J, Ladewig J, Mertens J, Tüting T, Hoffmann P, Klockgether T, Evert BO, Wüllner U, Brüstle O. Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease. Nature. 480: 543-6. PMID 22113611 DOI: 10.1038/Nature10671  0.495
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