| Year |
Citation |
Score |
| 2023 |
Driggers CM, Kuo YY, Zhu P, ElSheikh A, Shyng SL. Structure of an open K channel reveals tandem PIP binding sites mediating the Kir6.2 and SUR1 regulatory interface. Biorxiv : the Preprint Server For Biology. PMID 37577494 DOI: 10.1101/2023.08.01.551546 |
0.642 |
|
| 2023 |
ElSheikh A, Shyng SL. K channel mutations in congenital hyperinsulinism: Progress and challenges towards mechanism-based therapies. Frontiers in Endocrinology. 14: 1161117. PMID 37056678 DOI: 10.3389/fendo.2023.1161117 |
0.471 |
|
| 2023 |
Martin GM, Patton BL, Shyng SL. K channels in focus: Progress toward a structural understanding of ligand regulation. Current Opinion in Structural Biology. 79: 102541. PMID 36807078 DOI: 10.1016/j.sbi.2023.102541 |
0.57 |
|
| 2022 |
Driggers CM, Shyng SL. Mechanistic insights on KATP channel regulation from cryo-EM structures. The Journal of General Physiology. 155. PMID 36441147 DOI: 10.1085/jgp.202113046 |
0.624 |
|
| 2022 |
Woo Sung M, Driggers CM, Mostofian B, Russo JD, Patton BL, Zuckerman DM, Shyng SL. Ligand-mediated structural dynamics of a mammalian pancreatic K channel. Journal of Molecular Biology. 167789. PMID 35964676 DOI: 10.1016/j.jmb.2022.167789 |
0.586 |
|
| 2022 |
Yang HQ, Echeverry FA, ElSheikh A, Gando I, Anez Arredondo S, Samper N, Cardozo T, Delmar M, Shyng SL, Coetzee WA. KATP channel trafficking. American Journal of Physiology. Cell Physiology. PMID 35508187 DOI: 10.1152/ajpcell.00099.2022 |
0.588 |
|
| 2022 |
Shyng SL. K Channel Function: More than Meets the Eye. Function (Oxford, England). 3: zqab070. PMID 35059642 DOI: 10.1093/function/zqab070 |
0.441 |
|
| 2021 |
Sung MW, Yang Z, Driggers CM, Patton BL, Mostofian B, Russo JD, Zuckerman DM, Shyng SL. Vascular K channel structural dynamics reveal regulatory mechanism by Mg-nucleotides. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34711681 DOI: 10.1073/pnas.2109441118 |
0.521 |
|
| 2021 |
Driggers CM, Shyng SL. Production and purification of ATP-sensitive potassium channel particles for cryo-electron microscopy. Methods in Enzymology. 653: 121-150. PMID 34099169 DOI: 10.1016/bs.mie.2021.02.008 |
0.668 |
|
| 2021 |
Cochrane VA, Yang Z, Dell'Acqua ML, Shyng SL. AKAP79/150 coordinates leptin-induced PKA signaling to regulate K channel trafficking in pancreatic β-cells. The Journal of Biological Chemistry. 100442. PMID 33617875 DOI: 10.1016/j.jbc.2021.100442 |
0.394 |
|
| 2021 |
Saint-Martin C, Mière MC, Rex E, Soukarieh O, Arnoux JB, Buratti J, Bouvet D, Frébourg T, Gaildrat P, Shyng SL, Bellanné-Chantelot C, Martins A. Functional characterization of ABCC8 variants of unknown significance based on bioinformatics predictions, splicing assays and protein analyses: benefits for the accurate diagnosis of congenital hyperinsulinism. Human Mutation. PMID 33410562 DOI: 10.1002/humu.24164 |
0.395 |
|
| 2020 |
Cochrane V, Shyng S. Leptin activates PKA via a novel mechanism to regulate K
ATP
channel trafficking in pancreatic β‐cells The Faseb Journal. 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.02649 |
0.537 |
|
| 2019 |
Martin GM, Sung MW, Shyng SL. Pharmacological chaperones of ATP-sensitive potassium channels: Mechanistic insight from cryoEM structures. Molecular and Cellular Endocrinology. 110667. PMID 31821855 DOI: 10.1016/j.mce.2019.110667 |
0.669 |
|
| 2019 |
Boodhansingh KE, Kandasamy B, Mitteer L, Givler S, De Leon DD, Shyng SL, Ganguly A, Stanley CA. Novel dominant K channel mutations in infants with congenital hyperinsulinism: Validation by in vitro expression studies and in vivo carrier phenotyping. American Journal of Medical Genetics. Part A. PMID 31464105 DOI: 10.1002/ajmg.a.61335 |
0.435 |
|
| 2019 |
Martin GM, Sung MW, Yang Z, Innes LM, Kandasamy B, David LL, Yoshioka C, Shyng SL. Mechanism of pharmacochaperoning in a mammalian K channel revealed by cryo-EM. Elife. 8. PMID 31343405 DOI: 10.7554/eLife.46417 |
0.639 |
|
| 2019 |
Cochrane V, Shyng SL. Leptin-induced Trafficking of K Channels: A Mechanism to Regulate Pancreatic β-cell Excitability and Insulin Secretion. International Journal of Molecular Sciences. 20. PMID 31151172 DOI: 10.3390/ijms20112660 |
0.502 |
|
| 2019 |
Balamurugan K, Kavitha B, Yang Z, Mohan V, Radha V, Shyng SL. Functional characterization of activating mutations in the SUR1 (ABCC8) causing neonatal diabetes mellitus in Asian Indian children. Pediatric Diabetes. PMID 30861254 DOI: 10.1111/pedi.12843 |
0.438 |
|
| 2018 |
Kandasamy B, Shyng SL. Methods for Characterizing Disease-Associated ATP-Sensitive Potassium Channel Mutations. Methods in Molecular Biology (Clifton, N.J.). 1684: 85-104. PMID 29058186 DOI: 10.1007/978-1-4939-7362-0_8 |
0.643 |
|
| 2018 |
Devaraneni P, Rex EA, Shyng SL. Probing Subunits Interactions in KATP Channels Using Photo-Crosslinking via Genetically Encoded p-Azido-L-phenylalanine. Methods in Molecular Biology (Clifton, N.J.). 1684: 51-61. PMID 29058183 DOI: 10.1007/978-1-4939-7362-0_5 |
0.496 |
|
| 2017 |
Martin GM, Kandasamy B, DiMaio F, Yoshioka C, Shyng SL. Anti-diabetic drug binding site in a mammalian KATP channels revealed by Cryo-EM. Elife. 6. PMID 29035201 DOI: 10.7554/Elife.31054 |
0.522 |
|
| 2017 |
Wu Y, Fortin DA, Cochrane VA, Chen PC, Shyng SL. NMDA receptors mediate leptin signaling and regulate potassium channel trafficking in pancreatic β-cells. The Journal of Biological Chemistry. PMID 28768770 DOI: 10.1074/Jbc.M117.802249 |
0.42 |
|
| 2017 |
Martin GM, Yoshioka C, Rex EA, Fay JF, Xie Q, Whorton MR, Chen JZ, Shyng SL. Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating. Elife. 6. PMID 28092267 DOI: 10.7554/Elife.24149 |
0.59 |
|
| 2016 |
Martin GM, Rex EA, Devaraneni P, Denton JS, Boodhansingh KE, DeLeon DD, Stanley CA, Shyng SL. Pharmacological Correction of Trafficking Defects in ATP-Sensitive Potassium Channels Caused by Sulfonylurea Receptor 1 Mutations. The Journal of Biological Chemistry. PMID 27573238 DOI: 10.1074/Jbc.M116.749366 |
0.701 |
|
| 2015 |
Wu Y, Shyng SL, Chen PC. Concerted Trafficking Regulation of Kv2.1 and KATP Channels by Leptin in Pancreatic β-cells. The Journal of Biological Chemistry. PMID 26453299 DOI: 10.1074/jbc.M115.670877 |
0.562 |
|
| 2015 |
Devaraneni PK, Martin GM, Olson EM, Zhou Q, Shyng SL. Structurally distinct ligands rescue biogenesis defects of the KATP channel complex via a converging mechanism. The Journal of Biological Chemistry. 290: 7980-91. PMID 25637631 DOI: 10.1074/jbc.M114.634576 |
0.581 |
|
| 2015 |
Saint-Martin C, Zhou Q, Martin GM, Vaury C, Leroy G, Arnoux JB, de Lonlay P, Shyng SL, Bellanné-Chantelot C. Monoallelic ABCC8 mutations are a common cause of diazoxide-unresponsive diffuse form of congenital hyperinsulinism. Clinical Genetics. 87: 448-54. PMID 24814349 DOI: 10.1111/cge.12428 |
0.344 |
|
| 2014 |
Zhou Q, Chen PC, Devaraneni PK, Martin GM, Olson EM, Shyng SL. Carbamazepine inhibits ATP-sensitive potassium channel activity by disrupting channel response to MgADP. Channels (Austin, Tex.). 8: 376-82. PMID 24849284 DOI: 10.4161/chan.29117 |
0.687 |
|
| 2014 |
Devaraneni P, Zhou Q, Olson E, Shyng S. Mechanism of Carbamazepine Mediated Rescue of Trafficking Defective Mutant KATP Channels Biophysical Journal. 106: 542a. DOI: 10.1016/J.BPJ.2013.11.3020 |
0.541 |
|
| 2013 |
Martin GM, Chen PC, Devaraneni P, Shyng SL. Pharmacological rescue of trafficking-impaired ATP-sensitive potassium channels. Frontiers in Physiology. 4: 386. PMID 24399968 DOI: 10.3389/fphys.2013.00386 |
0.677 |
|
| 2013 |
Chen PC, Kryukova YN, Shyng SL. Leptin regulates KATP channel trafficking in pancreatic β-cells by a signaling mechanism involving AMP-activated protein kinase (AMPK) and cAMP-dependent protein kinase (PKA). The Journal of Biological Chemistry. 288: 34098-109. PMID 24100028 DOI: 10.1074/jbc.M113.516880 |
0.556 |
|
| 2013 |
Chen PC, Olson EM, Zhou Q, Kryukova Y, Sampson HM, Thomas DY, Shyng SL. Carbamazepine as a novel small molecule corrector of trafficking-impaired ATP-sensitive potassium channels identified in congenital hyperinsulinism. The Journal of Biological Chemistry. 288: 20942-54. PMID 23744072 DOI: 10.1074/jbc.M113.470948 |
0.681 |
|
| 2013 |
Bushman JD, Zhou Q, Shyng SL. A Kir6.2 pore mutation causes inactivation of ATP-sensitive potassium channels by disrupting PIP2-dependent gating. Plos One. 8: e63733. PMID 23700433 DOI: 10.1371/journal.pone.0063733 |
0.866 |
|
| 2013 |
Zhou Q, Pratt EB, Shyng SL. Engineered Kir6.2 mutations that correct the trafficking defect of K(ATP) channels caused by specific SUR1 mutations. Channels (Austin, Tex.). 7: 313-7. PMID 23695995 DOI: 10.4161/Chan.25003 |
0.843 |
|
| 2013 |
Faletra F, Snider K, Shyng SL, Bruno I, Athanasakis E, Gasparini P, Dionisi-Vici C, Ventura A, Zhou Q, Stanley CA, Burlina A. Co-inheritance of two ABCC8 mutations causing an unresponsive congenital hyperinsulinism: clinical and functional characterization of two novel ABCC8 mutations. Gene. 516: 122-5. PMID 23266803 DOI: 10.1016/j.gene.2012.12.055 |
0.351 |
|
| 2012 |
Pratt EB, Zhou Q, Gay JW, Shyng SL. Engineered interaction between SUR1 and Kir6.2 that enhances ATP sensitivity in KATP channels. The Journal of General Physiology. 140: 175-87. PMID 22802363 DOI: 10.1085/Jgp.201210803 |
0.871 |
|
| 2012 |
Wang F, Olson EM, Shyng SL. Role of Derlin-1 protein in proteostasis regulation of ATP-sensitive potassium channels. The Journal of Biological Chemistry. 287: 10482-93. PMID 22311976 DOI: 10.1074/jbc.M111.312223 |
0.636 |
|
| 2012 |
Lynch CJ, Zhou Q, Shyng SL, Heal DJ, Cheetham SC, Dickinson K, Gregory P, Firnges M, Nordheim U, Goshorn S, Reiche D, Turski L, Antel J. Some cannabinoid receptor ligands and their distomers are direct-acting openers of SUR1 K(ATP) channels. American Journal of Physiology. Endocrinology and Metabolism. 302: E540-51. PMID 22167524 DOI: 10.1152/ajpendo.00250.2011 |
0.426 |
|
| 2012 |
Shemer R, Avnon Ziv C, Laiba E, Zhou Q, Gay J, Tunovsky-Babaey S, Shyng SL, Glaser B, Zangen DH. Relative expression of a dominant mutated ABCC8 allele determines the clinical manifestation of congenital hyperinsulinism. Diabetes. 61: 258-63. PMID 22106158 DOI: 10.2337/db11-0984 |
0.442 |
|
| 2012 |
Shyng SL, Bushman JD, Pratt EB, Zhou Q. Molecular defects of ATP-sensitive potassium channels in congenital hyperinsulinism Monogenic Hyperinsulinemic Hypoglycemia Disorders. 21: 30-42. DOI: 10.1159/000334485 |
0.833 |
|
| 2011 |
Pratt EB, Shyng SL. ATP activates ATP-sensitive potassium channels composed of mutant sulfonylurea receptor 1 and Kir6.2 with diminished PIP2 sensitivity. Channels (Austin, Tex.). 5: 314-9. PMID 21654216 DOI: 10.4161/Chan.5.4.16510 |
0.865 |
|
| 2011 |
Bruederle CE, Gay J, Shyng SL. A role of the sulfonylurea receptor 1 in endocytic trafficking of ATP-sensitive potassium channels. Traffic (Copenhagen, Denmark). 12: 1242-56. PMID 21649805 DOI: 10.1111/j.1600-0854.2011.01227.x |
0.689 |
|
| 2011 |
Macmullen CM, Zhou Q, Snider KE, Tewson PH, Becker SA, Aziz AR, Ganguly A, Shyng SL, Stanley CA. Diazoxide-unresponsive congenital hyperinsulinism in children with dominant mutations of the β-cell sulfonylurea receptor SUR1. Diabetes. 60: 1797-804. PMID 21536946 DOI: 10.2337/db10-1631 |
0.503 |
|
| 2011 |
Pratt EB, Tewson P, Bruederle CE, Skach WR, Shyng SL. N-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP2. The Journal of General Physiology. 137: 299-314. PMID 21321069 DOI: 10.1085/Jgp.201010557 |
0.873 |
|
| 2011 |
Chen PC, Bruederle CE, Gaisano HY, Shyng SL. Syntaxin 1A regulates surface expression of beta-cell ATP-sensitive potassium channels. American Journal of Physiology. Cell Physiology. 300: C506-16. PMID 21209369 DOI: 10.1152/Ajpcell.00429.2010 |
0.564 |
|
| 2011 |
Kang Y, Zhang Y, Liang T, Leung YM, Ng B, Xie H, Chang N, Chan J, Shyng SL, Tsushima RG, Gaisano HY. ATP modulates interaction of syntaxin-1A with sulfonylurea receptor 1 to regulate pancreatic beta-cell KATP channels. The Journal of Biological Chemistry. 286: 5876-83. PMID 21173146 DOI: 10.1074/Jbc.M109.089607 |
0.496 |
|
| 2011 |
Pratt EB, Shyng SL. ATP activates ATP-sensitive potassium channels composed of mutant sulfonylurea receptor 1 and Kir6.2 with diminished PIP 2 sensitivity Channels. 5. |
0.841 |
|
| 2010 |
Zhou Q, Garin I, Castaño L, Argente J, Muñoz-Calvo MT, Perez de Nanclares G, Shyng SL. Neonatal diabetes caused by mutations in sulfonylurea receptor 1: interplay between expression and Mg-nucleotide gating defects of ATP-sensitive potassium channels. The Journal of Clinical Endocrinology and Metabolism. 95: E473-8. PMID 20810569 DOI: 10.1210/Jc.2010-1231 |
0.658 |
|
| 2010 |
Yan FF, Pratt EB, Chen PC, Wang F, Skach WR, David LL, Shyng SL. Role of Hsp90 in biogenesis of the beta-cell ATP-sensitive potassium channel complex. Molecular Biology of the Cell. 21: 1945-54. PMID 20427569 DOI: 10.1091/Mbc.E10-02-0116 |
0.862 |
|
| 2010 |
Bushman JD, Gay JW, Tewson P, Stanley CA, Shyng SL. Characterization and functional restoration of a potassium channel Kir6.2 pore mutation identified in congenital hyperinsulinism. The Journal of Biological Chemistry. 285: 6012-23. PMID 20032456 DOI: 10.1074/jbc.M109.085860 |
0.885 |
|
| 2010 |
Pratt EB, Tewson P, Shyng S. Sulfonylurea Receptor Transmembrane Domain Zero Mutations that Disrupt Full Length and Minimal ATP-Sensitive Potassium Channel Properties Biophysical Journal. 98: 699a. DOI: 10.1016/J.Bpj.2009.12.3838 |
0.862 |
|
| 2010 |
Zhou Q, Ziv CA, Glaser B, Zangen DH, Shyng S. Identification of a Heterozygous Sulfonylurea Receptor 1 Mutation that Exerts a Strong Dominant-Negative Effect on KATP Channel Response to MgADP Biophysical Journal. 98: 699a. DOI: 10.1016/J.BPJ.2009.12.3837 |
0.521 |
|
| 2009 |
Fu Y, Tian W, Pratt EB, Dirling LB, Shyng SL, Meshul CK, Cohen DM. Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion. Plos One. 4: e5679. PMID 19479076 DOI: 10.1371/Journal.Pone.0005679 |
0.712 |
|
| 2009 |
Pratt EB, Yan FF, Gay JW, Stanley CA, Shyng SL. Sulfonylurea receptor 1 mutations that cause opposite insulin secretion defects with chemical chaperone exposure. The Journal of Biological Chemistry. 284: 7951-9. PMID 19151370 DOI: 10.1074/Jbc.M807012200 |
0.872 |
|
| 2009 |
Bushman JD, Tewson PH, Shyng S. Rescue and Gating of a Disease Mutation at an M2 glycine in Kir6.2 of ATP-Sensitive Potassium (KATP) Channels Biophysical Journal. 96: 465a-466a. DOI: 10.1016/J.BPJ.2008.12.2397 |
0.871 |
|
| 2008 |
Pinney SE, MacMullen C, Becker S, Lin YW, Hanna C, Thornton P, Ganguly A, Shyng SL, Stanley CA. Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations. The Journal of Clinical Investigation. 118: 2877-86. PMID 18596924 DOI: 10.1172/JCI35414 |
0.717 |
|
| 2008 |
Abdulhadi-Atwan M, Bushman J, Bushmann J, Tornovsky-Babaey S, Perry A, Abu-Libdeh A, Glaser B, Shyng SL, Zangen DH. Novel de novo mutation in sulfonylurea receptor 1 presenting as hyperinsulinism in infancy followed by overt diabetes in early adolescence. Diabetes. 57: 1935-40. PMID 18390792 DOI: 10.2337/db08-0159 |
0.8 |
|
| 2008 |
Lin YW, Bushman JD, Yan FF, Haidar S, MacMullen C, Ganguly A, Stanley CA, Shyng SL. Destabilization of ATP-sensitive potassium channel activity by novel KCNJ11 mutations identified in congenital hyperinsulinism. The Journal of Biological Chemistry. 283: 9146-56. PMID 18250167 DOI: 10.1074/jbc.M708798200 |
0.884 |
|
| 2007 |
Yan FF, Lin YW, MacMullen C, Ganguly A, Stanley CA, Shyng SL. Congenital hyperinsulinism associated ABCC8 mutations that cause defective trafficking of ATP-sensitive K+ channels: identification and rescue. Diabetes. 56: 2339-48. PMID 17575084 DOI: 10.2337/db07-0150 |
0.772 |
|
| 2006 |
Yan FF, Casey J, Shyng SL. Sulfonylureas correct trafficking defects of disease-causing ATP-sensitive potassium channels by binding to the channel complex. The Journal of Biological Chemistry. 281: 33403-13. PMID 16956886 DOI: 10.1074/jbc.M605195200 |
0.674 |
|
| 2006 |
Lin CW, Lin YW, Yan FF, Casey J, Kochhar M, Pratt EB, Shyng SL. Kir6.2 mutations associated with neonatal diabetes reduce expression of ATP-sensitive K+ channels: implications in disease mechanism and sulfonylurea therapy. Diabetes. 55: 1738-46. PMID 16731837 DOI: 10.2337/Db05-1571 |
0.879 |
|
| 2006 |
Lin YW, MacMullen C, Ganguly A, Stanley CA, Shyng SL. A novel KCNJ11 mutation associated with congenital hyperinsulinism reduces the intrinsic open probability of beta-cell ATP-sensitive potassium channels. The Journal of Biological Chemistry. 281: 3006-12. PMID 16332676 DOI: 10.1074/jbc.M511875200 |
0.795 |
|
| 2005 |
Lin CW, Yan F, Shimamura S, Barg S, Shyng SL. Membrane phosphoinositides control insulin secretion through their effects on ATP-sensitive K+ channel activity. Diabetes. 54: 2852-8. PMID 16186385 DOI: 10.2337/diabetes.54.10.2852 |
0.76 |
|
| 2005 |
Yan FF, Lin CW, Cartier EA, Shyng SL. Role of ubiquitin-proteasome degradation pathway in biogenesis efficiency of {beta}-cell ATP-sensitive potassium channels. American Journal of Physiology. Cell Physiology. 289: C1351-9. PMID 15987767 DOI: 10.1152/Ajpcell.00240.2005 |
0.862 |
|
| 2004 |
Magge SN, Shyng SL, MacMullen C, Steinkrauss L, Ganguly A, Katz LE, Stanley CA. Familial leucine-sensitive hypoglycemia of infancy due to a dominant mutation of the beta-cell sulfonylurea receptor. The Journal of Clinical Endocrinology and Metabolism. 89: 4450-6. PMID 15356046 DOI: 10.1210/jc.2004-0441 |
0.342 |
|
| 2004 |
Yan F, Lin CW, Weisiger E, Cartier EA, Taschenberger G, Shyng SL. Sulfonylureas correct trafficking defects of ATP-sensitive potassium channels caused by mutations in the sulfonylurea receptor. The Journal of Biological Chemistry. 279: 11096-105. PMID 14707124 DOI: 10.1074/Jbc.M312810200 |
0.886 |
|
| 2004 |
Nichols CG, Shyng SL, Marshall B, Koster JC. ATP-sensitive potassium channels and insulin secretion diseases Advances in Molecular and Cell Biology. 32: 1-14. DOI: 10.1016/S1569-2558(03)32001-6 |
0.7 |
|
| 2003 |
Lin YW, Jia T, Weinsoft AM, Shyng SL. Stabilization of the activity of ATP-sensitive potassium channels by ion pairs formed between adjacent Kir6.2 subunits. The Journal of General Physiology. 122: 225-37. PMID 12885877 DOI: 10.1085/jgp.200308822 |
0.698 |
|
| 2003 |
Cartier EA, Shen S, Shyng SL. Modulation of the trafficking efficiency and functional properties of ATP-sensitive potassium channels through a single amino acid in the sulfonylurea receptor. The Journal of Biological Chemistry. 278: 7081-90. PMID 12496311 DOI: 10.1074/Jbc.M211395200 |
0.858 |
|
| 2002 |
Huopio H, Shyng SL, Otonkoski T, Nichols CG. K(ATP) channels and insulin secretion disorders. American Journal of Physiology. Endocrinology and Metabolism. 283: E207-16. PMID 12110524 DOI: 10.1152/ajpendo.00047.2002 |
0.736 |
|
| 2002 |
Taschenberger G, Mougey A, Shen S, Lester LB, LaFranchi S, Shyng SL. Identification of a familial hyperinsulinism-causing mutation in the sulfonylurea receptor 1 that prevents normal trafficking and function of KATP channels. The Journal of Biological Chemistry. 277: 17139-46. PMID 11867634 DOI: 10.1074/jbc.M200363200 |
0.689 |
|
| 2001 |
Conti LR, Radeke CM, Shyng SL, Vandenberg CA. Transmembrane topology of the sulfonylurea receptor SUR1. The Journal of Biological Chemistry. 276: 41270-8. PMID 11546780 DOI: 10.1074/Jbc.M106555200 |
0.325 |
|
| 2001 |
Cartier EA, Conti LR, Vandenberg CA, Shyng SL. Defective trafficking and function of KATP channels caused by a sulfonylurea receptor 1 mutation associated with persistent hyperinsulinemic hypoglycemia of infancy. Proceedings of the National Academy of Sciences of the United States of America. 98: 2882-7. PMID 11226335 DOI: 10.1073/Pnas.051499698 |
0.876 |
|
| 2000 |
Shyng SL, Cukras CA, Harwood J, Nichols CG. Structural determinants of PIP(2) regulation of inward rectifier K(ATP) channels. The Journal of General Physiology. 116: 599-608. PMID 11055989 DOI: 10.1085/jgp.116.5.599 |
0.845 |
|
| 2000 |
Enkvetchakul D, Loussouarn G, Makhina E, Shyng SL, Nichols CG. The kinetic and physical basis of K(ATP) channel gating: toward a unified molecular understanding. Biophysical Journal. 78: 2334-48. PMID 10777731 DOI: 10.1016/S0006-3495(00)76779-8 |
0.736 |
|
| 2000 |
Shyng SL, Barbieri A, Gumusboga A, Cukras C, Pike L, Davis JN, Stahl PD, Nichols CG. Modulation of nucleotide sensitivity of ATP-sensitive potassium channels by phosphatidylinositol-4-phosphate 5-kinase. Proceedings of the National Academy of Sciences of the United States of America. 97: 937-41. PMID 10639183 DOI: 10.1073/Pnas.97.2.937 |
0.829 |
|
| 1999 |
Shyng SL, Nichols CG. Nucleotides and insulin secretion. Nutrition (Burbank, Los Angeles County, Calif.). 15: 717-9. PMID 10467619 DOI: 10.1016/S0899-9007(99)00126-4 |
0.485 |
|
| 1999 |
Koster JC, Sha Q, Shyng S, Nichols CG. ATP inhibition of KATP channels: control of nucleotide sensitivity by the N-terminal domain of the Kir6.2 subunit. The Journal of Physiology. 515: 19-30. PMID 9925874 DOI: 10.1111/J.1469-7793.1999.019Ad.X |
0.783 |
|
| 1999 |
Koster JC, Sha Q, Shyng SL, Nichols CG. ATP inhibition of K(ATP) channels: Control of nucleotide sensitivity by the N-terminal domain of the Kir6.2 subunit Journal of Physiology. 515: 19-30. |
0.672 |
|
| 1998 |
Shyng SL, Nichols CG. Membrane phospholipid control of nucleotide sensitivity of KATP channels. Science (New York, N.Y.). 282: 1138-41. PMID 9804554 DOI: 10.1126/Science.282.5391.1138 |
0.722 |
|
| 1998 |
Shyng SL, Ferrigni T, Shepard JB, Nestorowicz A, Glaser B, Permutt MA, Nichols CG. Functional analyses of novel mutations in the sulfonylurea receptor 1 associated with persistent hyperinsulinemic hypoglycemia of infancy. Diabetes. 47: 1145-51. PMID 9648840 DOI: 10.2337/diabetes.47.7.1145 |
0.795 |
|
| 1998 |
Nestorowicz A, Glaser B, Wilson BA, Shyng SL, Nichols CG, Stanley CA, Thornton PS, Permutt MA. Genetic heterogeneity in familial hyperinsulinism. Human Molecular Genetics. 7: 1119-28. PMID 9618169 DOI: 10.1093/hmg/7.7.1119 |
0.501 |
|
| 1997 |
Shyng S, Nichols CG. Octameric stoichiometry of the KATP channel complex. The Journal of General Physiology. 110: 655-64. PMID 9382894 DOI: 10.1085/jgp.110.6.655 |
0.771 |
|
| 1997 |
Shyng S, Ferrigni T, Nichols CG. Regulation of KATP channel activity by diazoxide and MgADP. Distinct functions of the two nucleotide binding folds of the sulfonylurea receptor. The Journal of General Physiology. 110: 643-54. PMID 9382893 DOI: 10.1085/jgp.110.6.643 |
0.778 |
|
| 1997 |
Shyng S, Ferrigni T, Nichols CG. Control of rectification and gating of cloned KATP channels by the Kir6.2 subunit. The Journal of General Physiology. 110: 141-53. PMID 9236207 DOI: 10.1085/jgp.110.2.141 |
0.767 |
|
| 1996 |
Shyng SL, Sha Q, Ferrigni T, Lopatin AN, Nichols CG. Depletion of intracellular polyamines relieves inward rectification of potassium channels. Proceedings of the National Academy of Sciences of the United States of America. 93: 12014-9. PMID 8876254 DOI: 10.1073/Pnas.93.21.12014 |
0.645 |
|
| 1996 |
Nichols CG, Shyng SL, Nestorowicz A, Glaser B, Clement JP, Gonzalez G, Aguilar-Bryan L, Permutt MA, Bryan J. Adenosine diphosphate as an intracellular regulator of insulin secretion. Science (New York, N.Y.). 272: 1785-7. PMID 8650576 DOI: 10.1126/Science.272.5269.1785 |
0.733 |
|
| 1996 |
Harris DA, Gorodinsky A, Lehmann S, Moulder K, Shyng SL. Cell biology of the prion protein. Current Topics in Microbiology and Immunology. 207: 77-93. PMID 8575208 DOI: 10.1007/978-3-642-60983-1_7 |
0.425 |
|
| 1996 |
Permitt MA, Neftorowicz A, Sohoor K, Wilson BA, Nichols CG, Shyng SL, Qlmer B, Stanley C, Paul S, Biyan TJ, Agullv-Biyan L. Identification of mutations in the sulfonylurea receptor gene associated with fame.ial hyperinsulinism Journal of Investigative Medicine. 44: 314a. |
0.466 |
|
| 1995 |
Shyng SL, Lehmann S, Moulder KL, Harris DA. Sulfated glycans stimulate endocytosis of the cellular isoform of the prion protein, PrPC, in cultured cells. The Journal of Biological Chemistry. 270: 30221-9. PMID 8530433 DOI: 10.1074/Jbc.270.50.30221 |
0.375 |
|
| 1995 |
Shyng SL, Moulder KL, Lesko A, Harris DA. The N-terminal domain of a glycolipid-anchored prion protein is essential for its endocytosis via clathrin-coated pits. The Journal of Biological Chemistry. 270: 14793-800. PMID 7782345 DOI: 10.1074/jbc.270.24.14793 |
0.426 |
|
| 1994 |
Shyng SL, Heuser JE, Harris DA. A glycolipid-anchored prion protein is endocytosed via clathrin-coated pits. The Journal of Cell Biology. 125: 1239-50. PMID 7911471 DOI: 10.1083/jcb.125.6.1239 |
0.414 |
|
| 1993 |
Shyng SL, Huber MT, Harris DA. A prion protein cycles between the cell surface and an endocytic compartment in cultured neuroblastoma cells. The Journal of Biological Chemistry. 268: 15922-8. PMID 8101844 |
0.375 |
|
| 1993 |
Harris DA, Huber MT, van Dijken P, Shyng SL, Chait BT, Wang R. Processing of a cellular prion protein: identification of N- and C-terminal cleavage sites. Biochemistry. 32: 1009-16. PMID 8093841 DOI: 10.1021/Bi00055A003 |
0.361 |
|
| 1991 |
Shyng SL, Xu R, Salpeter MM. Cyclic AMP stabilizes the degradation of original junctional acetylcholine receptors in denervated muscle. Neuron. 6: 469-75. PMID 1848083 DOI: 10.1016/0896-6273(91)90254-W |
0.512 |
|
| 1990 |
Shyng SL, Salpeter MM. Effect of reinnervation on the degradation rate of junctional acetylcholine receptors synthesized in denervated skeletal muscles. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 3905-15. PMID 2269890 DOI: 10.1523/Jneurosci.10-12-03905.1990 |
0.494 |
|
| 1989 |
Shyng SL, Salpeter MM. Degradation rate of acetylcholine receptors inserted into denervated vertebrate neuromuscular junctions. The Journal of Cell Biology. 108: 647-51. PMID 2918028 |
0.499 |
|
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