| Year |
Citation |
Score |
| 2024 |
Sprague JL, Schille TB, Allert S, Trümper V, Lier A, Großmann P, Priest EL, Tsavou A, Panagiotou G, Naglik JR, Wilson D, Schäuble S, Kasper L, Hube B. Candida albicans translocation through the intestinal epithelial barrier is promoted by fungal zinc acquisition and limited by NFκB-mediated barrier protection. Plos Pathogens. 20: e1012031. PMID 38427950 DOI: 10.1371/journal.ppat.1012031 |
0.436 |
|
| 2024 |
Valentine M, Rudolph P, Dietschmann A, Tsavou A, Mogavero S, Lee S, Priest EL, Zhurgenbayeva G, Jablonowski N, Timme S, Eggeling C, Allert S, Dolk E, Naglik JR, Figge MT, et al. Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis. Mbio. e0340923. PMID 38349176 DOI: 10.1128/mbio.03409-23 |
0.343 |
|
| 2024 |
Launder D, Dillon JT, Wuescher LM, Glanz T, Abdul-Aziz N, Mein-Chiain Yi E, Naglik JR, Worth RG, Conti HR. Immunity to pathogenic mucosal C. albicans infections mediated by oral megakaryocytes activated by IL-17 and candidalysin. Mucosal Immunology. PMID 38246240 DOI: 10.1016/j.mucimm.2024.01.003 |
0.435 |
|
| 2023 |
Dickenson RE, Pellon A, Ponde NO, Hepworth O, Daniels Gatward LF, Naglik JR, Moyes DL. EGR1 regulates oral epithelial cell responses to via the EGFR- ERK1/2 pathway. Biorxiv : the Preprint Server For Biology. PMID 37066428 DOI: 10.1101/2023.03.31.535186 |
0.469 |
|
| 2023 |
Okaa UJ, Bertuzzi M, Fortune-Grant R, Thomson DD, Moyes DL, Naglik JR, Bignell E. Aspergillus fumigatus Drives Tissue Damage via Iterative Assaults upon Mucosal Integrity and Immune Homeostasis. Infection and Immunity. e0033322. PMID 36625602 DOI: 10.1128/iai.00333-22 |
0.373 |
|
| 2022 |
Ponde NO, Lortal L, Tsavou A, Hepworth OW, Wickramasinghe DN, Ho J, Richardson JP, Moyes DL, Gaffen SL, Naglik JR. Receptor-kinase EGFR-MAPK adaptor proteins mediate the epithelial response to Candida albicans via the cytolytic peptide toxin, candidalysin. The Journal of Biological Chemistry. 102419. PMID 36037968 DOI: 10.1016/j.jbc.2022.102419 |
0.624 |
|
| 2022 |
Nikou SA, Zhou C, Griffiths JS, Kotowicz NK, Coleman BM, Green MJ, Moyes DL, Gaffen SL, Naglik JR, Parker PJ. The toxin candidalysin mediates distinct epithelial inflammatory responses through p38 and EGFR-ERK pathways. Science Signaling. 15: eabj6915. PMID 35380879 DOI: 10.1126/scisignal.abj6915 |
0.59 |
|
| 2022 |
Richardson JP, Brown R, Kichik N, Lee S, Priest E, Mogavero S, Maufrais C, Wickramasinghe DN, Tsavou A, Kotowicz NK, Hepworth OW, Gallego-Cortés A, Ponde NO, Ho J, Moyes DL, ... ... Naglik JR, et al. Candidalysins Are a New Family of Cytolytic Fungal Peptide Toxins. Mbio. e0351021. PMID 35073742 DOI: 10.1128/mbio.03510-21 |
0.397 |
|
| 2022 |
Westman J, Plumb J, Licht A, Yang M, Allert S, Naglik JR, Hube B, Grinstein S, Maxson ME. Calcium-dependent ESCRT recruitment and lysosome exocytosis maintain epithelial integrity during Candida albicans invasion. Cell Reports. 38: 110187. PMID 34986345 DOI: 10.1016/j.celrep.2021.110187 |
0.306 |
|
| 2021 |
Mogavero S, Sauer FM, Brunke S, Allert S, Schulz D, Wisgott S, Jablonowski N, Elshafee O, Krüger T, Kniemeyer O, Brakhage AA, Naglik JR, Dolk E, Hube B. Candidalysin delivery to the invasion pocket is critical for host epithelial damage induced by Candida albicans. Cellular Microbiology. e13378. PMID 34245079 DOI: 10.1111/cmi.13378 |
0.357 |
|
| 2021 |
Austermeier S, Pekmezović M, Porschitz P, Lee S, Kichik N, Moyes DL, Ho J, Kotowicz NK, Naglik JR, Hube B, Gresnigt MS. Albumin Neutralizes Hydrophobic Toxins and Modulates Pathogenicity. Mbio. e0053121. PMID 34154403 DOI: 10.1128/mBio.00531-21 |
0.362 |
|
| 2021 |
Blagojevic M, Camilli G, Maxson M, Hube B, Moyes DL, Richardson JP, Naglik JR. Candidalysin triggers epithelial cellular stresses that induce necrotic death. Cellular Microbiology. e13371. PMID 34085369 DOI: 10.1111/cmi.13371 |
0.322 |
|
| 2021 |
Brown R, Priest E, Naglik JR, Richardson JP. Fungal Toxins and Host Immune Responses. Frontiers in Microbiology. 12: 643639. PMID 33927703 DOI: 10.3389/fmicb.2021.643639 |
0.335 |
|
| 2021 |
Griffiths JS, Camilli G, Kotowicz NK, Ho J, Richardson JP, Naglik JR. Role for IL-1 Family Cytokines in Fungal Infections. Frontiers in Microbiology. 12: 633047. PMID 33643264 DOI: 10.3389/fmicb.2021.633047 |
0.417 |
|
| 2021 |
Nikou S, Ho J, Hepworth O, Ponde N, Dickenson R, Richardson JP, Naglik JR. Analysis of Epithelial Cell Responses to Microbial Pathogens. Methods in Molecular Biology (Clifton, N.J.). 2260: 49-82. PMID 33405031 DOI: 10.1007/978-1-0716-1182-1_5 |
0.354 |
|
| 2020 |
Camilli G, Blagojevic M, Naglik JR, Richardson JP. Programmed Cell Death: Central Player in Fungal Infections. Trends in Cell Biology. PMID 33293167 DOI: 10.1016/j.tcb.2020.11.005 |
0.315 |
|
| 2020 |
Aggor FEY, Break TJ, Trevejo-Nuñez G, Whibley N, Coleman BM, Bailey RD, Kaplan DH, Naglik JR, Shan W, Shetty AC, McCracken C, Durum SK, Biswas PS, Bruno VM, Kolls JK, et al. Oral epithelial IL-22/STAT3 signaling licenses IL-17-mediated immunity to oral mucosal candidiasis. Science Immunology. 5. PMID 32503875 DOI: 10.1126/Sciimmunol.Aba0570 |
0.563 |
|
| 2020 |
Ho J, Wickramasinghe DN, Nikou SA, Hube B, Richardson JP, Naglik JR. Candidalysin Is a Potent Trigger of Alarmin and Antimicrobial Peptide Release in Epithelial Cells. Cells. 9. PMID 32178483 DOI: 10.3390/cells9030699 |
0.417 |
|
| 2019 |
Swidergall M, Khalaji M, Solis NV, Moyes DL, Drummond RA, Hube B, Lionakis MS, Murdoch C, Filler SG, Naglik JR. Candidalysin Is Required for Neutrophil Recruitment and Virulence During Systemic Candida albicans Infection. The Journal of Infectious Diseases. PMID 31401652 DOI: 10.1093/infdis/jiz322 |
0.428 |
|
| 2019 |
Naglik JR, Gaffen SL, Hube B. Candidalysin: discovery and function in Candida albicans infections. Current Opinion in Microbiology. 52: 100-109. PMID 31288097 DOI: 10.1016/J.Mib.2019.06.002 |
0.614 |
|
| 2019 |
Ho J, Yang X, Nikou SA, Kichik N, Donkin A, Ponde NO, Richardson JP, Gratacap RL, Archambault LS, Zwirner CP, Murciano C, Henley-Smith R, Thavaraj S, Tynan CJ, Gaffen SL, ... ... Naglik JR, et al. Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor. Nature Communications. 10: 2297. PMID 31127085 DOI: 10.1038/S41467-019-09915-2 |
0.575 |
|
| 2019 |
Drummond RA, Swamydas M, Oikonomou V, Zhai B, Dambuza IM, Schaefer BC, Bohrer AC, Mayer-Barber KD, Lira SA, Iwakura Y, Filler SG, Brown GD, Hube B, Naglik JR, Hohl TM, et al. CARD9 microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment. Nature Immunology. 20: 559-570. PMID 30996332 DOI: 10.1038/S41590-019-0377-2 |
0.454 |
|
| 2018 |
Kasper L, König A, Koenig PA, Gresnigt MS, Westman J, Drummond RA, Lionakis MS, Groß O, Ruland J, Naglik JR, Hube B. The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes. Nature Communications. 9: 4260. PMID 30323213 DOI: 10.1038/s41467-018-06607-1 |
0.397 |
|
| 2018 |
Verma AH, Zafar H, Ponde NO, Hepworth OW, Sihra D, Aggor FEY, Ainscough JS, Ho J, Richardson JP, Coleman BM, Hube B, Stacey M, McGeachy MJ, Naglik JR, Gaffen SL, et al. IL-36 and IL-1/IL-17 Drive Immunity to Oral Candidiasis via Parallel Mechanisms. Journal of Immunology (Baltimore, Md. : 1950). PMID 29891557 DOI: 10.4049/Jimmunol.1800515 |
0.593 |
|
| 2018 |
Allert S, Förster TM, Svensson CM, Richardson JP, Pawlik T, Hebecker B, Rudolphi S, Juraschitz M, Schaller M, Blagojevic M, Morschhäuser J, Figge MT, Jacobsen ID, Naglik JR, Kasper L, et al. Candida albicans-Induced Epithelial Damage Mediates Translocation through Intestinal Barriers. Mbio. 9. PMID 29871918 DOI: 10.1128/mBio.00915-18 |
0.345 |
|
| 2018 |
Richardson JP, Moyes DL, Ho J, Naglik JR. Candida innate immunity at the mucosa. Seminars in Cell & Developmental Biology. PMID 29501618 DOI: 10.1016/j.semcdb.2018.02.026 |
0.406 |
|
| 2018 |
Richardson JP, Mogavero S, Moyes DL, Blagojevic M, Krüger T, Verma AH, Coleman BM, De La Cruz Diaz J, Schulz D, Ponde NO, Carrano G, Kniemeyer O, Wilson D, Bader O, Enoiu SI, ... ... Naglik JR, et al. Processing of Candida albicans Ece1p Is Critical for Candidalysin Maturation and Fungal Virulence. Mbio. 9. PMID 29362237 DOI: 10.1128/Mbio.02178-17 |
0.606 |
|
| 2017 |
Naglik JR, König A, Hube B, Gaffen SL. Candida albicans-epithelial interactions and induction of mucosal innate immunity. Current Opinion in Microbiology. 40: 104-112. PMID 29156234 DOI: 10.1016/J.Mib.2017.10.030 |
0.614 |
|
| 2017 |
Richardson JP, Willems HME, Moyes DL, Shoaie S, Barker KS, Tan SL, Palmer GE, Hube B, Naglik JR, Peters BM. Candidalysin drives epithelial signaling, neutrophil recruitment, and immunopathology at the vaginal mucosa. Infection and Immunity. PMID 29109176 DOI: 10.1128/IAI.00645-17 |
0.523 |
|
| 2017 |
Verma AH, Richardson JP, Zhou C, Coleman BM, Moyes DL, Ho J, Huppler AR, Ramani K, McGeachy MJ, Mufazalov IA, Waisman A, Kane LP, Biswas PS, Hube B, Naglik JR, et al. Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin. Science Immunology. 2. PMID 29101209 DOI: 10.1126/Sciimmunol.Aam8834 |
0.645 |
|
| 2016 |
Conti HR, Bruno VM, Childs EE, Daugherty S, Hunter JP, Mengesha BG, Saevig DL, Hendricks MR, Coleman BM, Brane L, Solis N, Cruz JA, Verma AH, Garg AV, Hise AG, ... ... Naglik JR, et al. IL-17 Receptor Signaling in Oral Epithelial Cells Is Critical for Protection against Oropharyngeal Candidiasis. Cell Host & Microbe. 20: 606-617. PMID 27923704 DOI: 10.1016/J.Chom.2016.10.001 |
0.575 |
|
| 2016 |
Moyes DL, Wilson D, Richardson JP, Mogavero S, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Förster TM, Hebecker B, ... ... Naglik JR, et al. Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature. PMID 27027296 DOI: 10.1038/nature17625 |
0.393 |
|
| 2016 |
Moyes DL, Islam A, Kohli A, Naglik JR. Oral epithelial cells and their interactions with HIV-1. Oral Diseases. 22: 66-72. PMID 26879550 DOI: 10.1111/Odi.12410 |
0.349 |
|
| 2016 |
Tang S, Moyes D, Richardson J, Blagojevic M, Naglik J. Epithelial discrimination of commensal and pathogenic Candida albicans Oral Diseases. DOI: 10.1111/Odi.12395 |
0.441 |
|
| 2015 |
Moyes DL, Richardson JP, Naglik JR. Candida albicans-epithelial interactions and pathogenicity mechanisms: scratching the surface. Virulence. 6: 338-46. PMID 25714110 DOI: 10.1080/21505594.2015.1012981 |
0.314 |
|
| 2015 |
Achterman RR, Moyes DL, Thavaraj S, Smith AR, Blair KM, White TC, Naglik JR. Dermatophytes activate skin keratinocytes via mitogen-activated protein kinase signaling and induce immune responses. Infection and Immunity. 83: 1705-14. PMID 25667269 DOI: 10.1128/Iai.02776-14 |
0.365 |
|
| 2015 |
Foerster T, Mogavero S, Wilson D, Mayer F, Kasper L, Allert S, Hofs S, Naglik J, Hube B. The role of the pore-forming toxin Ece1 of Candida albicans during translocation through the intestinal epithelial barrier Mycoses. 58: 66-67. DOI: 10.1111/Myc.12362 |
0.328 |
|
| 2015 |
Mogavero S, Hoefs S, Lauer A, Luo T, Krueger T, Moyes D, Gutsmann T, Bader O, Naglik J, Wilson D, Hube B. Candida albicans ECE1 is responsible for pore induced damage of human host cells Mycoses. 58: 17-18. DOI: 10.1111/Myc.12361 |
0.379 |
|
| 2014 |
Naglik JR, Richardson JP, Moyes DL. Candida albicans pathogenicity and epithelial immunity. Plos Pathogens. 10: e1004257. PMID 25121985 DOI: 10.1371/journal.ppat.1004257 |
0.321 |
|
| 2014 |
Hebecker B, Naglik JR, Hube B, Jacobsen ID. Pathogenicity mechanisms and host response during oral Candida albicans infections. Expert Review of Anti-Infective Therapy. 12: 867-79. PMID 24803204 DOI: 10.1586/14787210.2014.916210 |
0.336 |
|
| 2014 |
Moyes DL, Shen C, Murciano C, Runglall M, Richardson JP, Arno M, Aldecoa-Otalora E, Naglik JR. Protection against epithelial damage during Candida albicans infection is mediated by PI3K/Akt and mammalian target of rapamycin signaling. The Journal of Infectious Diseases. 209: 1816-26. PMID 24357630 DOI: 10.1093/infdis/jit824 |
0.37 |
|
| 2014 |
Moyes DL, Tang SX, Richardson JP, Gratacap R, Wilson D, Bader O, Hoefs S, Moran G, Wheeler R, Hube B, Naglik J. The C. albicans hyphal protein, Ece1p, is a critical mucosal virulence factor and activates an epithelial cell 'danger' response Immunology. 143: 58-58. DOI: 10.1111/Imm.12405 |
0.433 |
|
| 2013 |
Wilson D, Hebecker B, Moyes DL, Miramón P, Jablonowski N, Wisgott S, Allert S, Naglik JR, Hube B. Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection. Antimicrobial Agents and Chemotherapy. 57: 5178-80. PMID 23896471 DOI: 10.1128/AAC.01244-13 |
0.348 |
|
| 2012 |
Wagener J, Weindl G, de Groot PW, de Boer AD, Kaesler S, Thavaraj S, Bader O, Mailänder-Sanchez D, Borelli C, Weig M, Biedermann T, Naglik JR, Korting HC, Schaller M. Glycosylation of Candida albicans cell wall proteins is critical for induction of innate immune responses and apoptosis of epithelial cells. Plos One. 7: e50518. PMID 23226301 DOI: 10.1371/journal.pone.0050518 |
0.396 |
|
| 2012 |
Murciano C, Moyes DL, Runglall M, Tobouti P, Islam A, Hoyer LL, Naglik JR. Evaluation of the role of Candida albicans agglutinin-like sequence (Als) proteins in human oral epithelial cell interactions. Plos One. 7: e33362. PMID 22428031 DOI: 10.1371/Journal.Pone.0033362 |
0.386 |
|
| 2012 |
Jacobsen ID, Wilson D, Wächtler B, Brunke S, Naglik JR, Hube B. Candida albicans dimorphism as a therapeutic target. Expert Review of Anti-Infective Therapy. 10: 85-93. PMID 22149617 DOI: 10.1586/eri.11.152 |
0.307 |
|
| 2012 |
Moyes DL, Murciano C, Runglall M, Kohli A, Islam A, Naglik JR. Activation of MAPK/c-Fos induced responses in oral epithelial cells is specific to Candida albicans and Candida dubliniensis hyphae. Medical Microbiology and Immunology. 201: 93-101. PMID 21706283 DOI: 10.1007/s00430-011-0209-y |
0.392 |
|
| 2011 |
Moyes DL, Murciano C, Runglall M, Islam A, Thavaraj S, Naglik JR. Candida albicans yeast and hyphae are discriminated by MAPK signaling in vaginal epithelial cells. Plos One. 6: e26580. PMID 22087232 DOI: 10.1371/journal.pone.0026580 |
0.439 |
|
| 2011 |
Murciano C, Moyes DL, Runglall M, Islam A, Mille C, Fradin C, Poulain D, Gow NA, Naglik JR. Candida albicans cell wall glycosylation may be indirectly required for activation of epithelial cell proinflammatory responses. Infection and Immunity. 79: 4902-11. PMID 21930756 DOI: 10.1128/Iai.05591-11 |
0.347 |
|
| 2011 |
Naglik JR, Moyes DL, Wächtler B, Hube B. Candida albicans interactions with epithelial cells and mucosal immunity. Microbes and Infection. 13: 963-76. PMID 21801848 DOI: 10.1016/j.micinf.2011.06.009 |
0.359 |
|
| 2011 |
Weinberg A, Naglik JR, Kohli A, Tugizov SM, Fidel PL, Liu Y, Herzberg M. Innate immunity including epithelial and nonspecific host factors: workshop 1B. Advances in Dental Research. 23: 122-9. PMID 21441493 DOI: 10.1177/0022034511399917 |
0.306 |
|
| 2011 |
Naglik JR, Moyes D. Epithelial cell innate response to Candida albicans. Advances in Dental Research. 23: 50-5. PMID 21441481 DOI: 10.1177/0022034511399285 |
0.41 |
|
| 2010 |
Moyes DL, Runglall M, Murciano C, Shen C, Nayar D, Thavaraj S, Kohli A, Islam A, Mora-Montes H, Challacombe SJ, Naglik JR. A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cells. Cell Host & Microbe. 8: 225-35. PMID 20833374 DOI: 10.1016/j.chom.2010.08.002 |
0.421 |
|
| 2008 |
Naglik JR, Fidel PL, Odds FC. Animal models of mucosal Candida infection. Fems Microbiology Letters. 283: 129-39. PMID 18422625 DOI: 10.1111/J.1574-6968.2008.01160.X |
0.363 |
|
| 2007 |
Weindl G, Naglik JR, Kaesler S, Biedermann T, Hube B, Korting HC, Schaller M. Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling. The Journal of Clinical Investigation. 117: 3664-72. PMID 17992260 DOI: 10.1172/JCI28115 |
0.395 |
|
| 2007 |
Zakikhany K, Naglik JR, Schmidt-Westhausen A, Holland G, Schaller M, Hube B. In vivo transcript profiling of Candida albicans identifies a gene essential for interepithelial dissemination. Cellular Microbiology. 9: 2938-54. PMID 17645752 DOI: 10.1111/j.1462-5822.2007.01009.x |
0.387 |
|
| 2006 |
Schaller M, Zakikhany K, Naglik JR, Weindl G, Hube B. Models of oral and vaginal candidiasis based on in vitro reconstituted human epithelia. Nature Protocols. 1: 2767-73. PMID 17406503 DOI: 10.1038/nprot.2006.474 |
0.364 |
|
| 2006 |
Challacombe S, Naglik J. The Effects of HIV Infection on Oral Mucosal Immunity Advances in Dental Research. 19: 29-35. PMID 16672546 DOI: 10.1177/154407370601900107 |
0.382 |
|
| 2006 |
Tavanti A, Campa D, Bertozzi A, Pardini G, Naglik JR, Barale R, Senesi S. Candida albicans isolates with different genomic backgrounds display a differential response to macrophage infection. Microbes and Infection / Institut Pasteur. 8: 791-800. PMID 16473540 DOI: 10.1016/j.micinf.2005.09.016 |
0.32 |
|
| 2006 |
Albrecht A, Felk A, Pichova I, Naglik JR, Schaller M, de Groot P, Maccallum D, Odds FC, Schäfer W, Klis F, Monod M, Hube B. Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions. The Journal of Biological Chemistry. 281: 688-94. PMID 16269404 DOI: 10.1074/Jbc.M509297200 |
0.33 |
|
| 2004 |
Naglik J, Albrecht A, Bader O, Hube B. Candida albicans proteinases and host/pathogen interactions. Cellular Microbiology. 6: 915-26. PMID 15339267 DOI: 10.1111/J.1462-5822.2004.00439.X |
0.46 |
|
| 2003 |
Naglik JR, Challacombe SJ, Hube B. Candida albicans secreted aspartyl proteinases in virulence and pathogenesis. Microbiology and Molecular Biology Reviews : Mmbr. 67: 400-28, table of con. PMID 12966142 DOI: 10.1128/mmbr.67.3.400-428.2003 |
0.411 |
|
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