Kari Alitalo, MD - Publications

Affiliations: 
Biomedicum Helsinki University of Helsinki, Helsingfors, Finland 
Area:
Vascularization
Website:
http://research.med.helsinki.fi/cancerbio/alitalo/index.html

211 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Korhonen EA, Lampinen A, Giri H, Anisimov A, Kim M, Allen B, Fang S, D'Amico G, Sipilä TJ, Lohela M, Strandin T, Vaheri A, Ylä-Herttuala S, Koh GY, McDonald DM, ... Alitalo K, et al. Tie1 controls angiopoietin function in vascular remodeling and inflammation. The Journal of Clinical Investigation. PMID 27548530 DOI: 10.1172/JCI84923  0.32
2016 Kim M, Allen B, Korhonen EA, Nitschké M, Yang HW, Baluk P, Saharinen P, Alitalo K, Daly C, Thurston G, McDonald DM. Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation. The Journal of Clinical Investigation. PMID 27548529 DOI: 10.1172/JCI84871  0.32
2016 Lund AW, Wagner M, Fankhauser M, Steinskog ES, Broggi MA, Spranger S, Gajewski TF, Alitalo K, Eikesdal HP, Wiig H, Swartz MA. Lymphatic vessels regulate immune microenvironments in human and murine melanoma. The Journal of Clinical Investigation. PMID 27525437 DOI: 10.1172/JCI79434  0.32
2016 Karaman S, Hollmén M, Yoon SY, Alkan HF, Alitalo K, Wolfrum C, Detmar M. Transgenic overexpression of VEGF-C induces weight gain and insulin resistance in mice. Scientific Reports. 6: 31566. PMID 27511834 DOI: 10.1038/srep31566  0.32
2016 Johns SC, Yin X, Jeltsch M, Bishop JR, Schuksz M, El Ghazal R, Wilcox-Adelman SA, Alitalo K, Fuster MM. Functional Importance of a Proteoglycan Co-Receptor in Pathologic Lymphangiogenesis. Circulation Research. PMID 27225479 DOI: 10.1161/CIRCRESAHA.116.308504  0.32
2016 Bui HM, Enis D, Robciuc MR, Nurmi HJ, Cohen J, Chen M, Yang Y, Dhillon V, Johnson K, Zhang H, Kirkpatrick R, Traxler E, Anisimov A, Alitalo K, Kahn ML. Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD. The Journal of Clinical Investigation. PMID 27159393 DOI: 10.1172/JCI83967  0.32
2016 Robciuc MR, Kivelä R, Williams IM, de Boer JF, van Dijk TH, Elamaa H, Tigistu-Sahle F, Molotkov D, Leppänen VM, Käkelä R, Eklund L, Wasserman DH, Groen AK, Alitalo K. VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications. Cell Metabolism. 23: 712-24. PMID 27076080 DOI: 10.1016/j.cmet.2016.03.004  0.32
2016 Aspelund A, Robciuc MR, Karaman S, Makinen T, Alitalo K. Lymphatic System in Cardiovascular Medicine. Circulation Research. 118: 515-30. PMID 26846644 DOI: 10.1161/CIRCRESAHA.115.306544  0.32
2015 Heindl LM, Kaser-Eichberger A, Schlereth SL, Bock F, Regenfuss B, Reitsamer HA, McMenamin P, Lutty GA, Maruyama K, Chen L, Dana R, Kerjaschki D, Alitalo K, De Stefano ME, Junghans BM, et al. Sufficient Evidence for Lymphatics in the Developing and Adult Human Choroid? Investigative Ophthalmology & Visual Science. 56: 6709-6710. PMID 26588256 DOI: 10.1167/iovs.15-17686  0.32
2015 Nurmi H, Saharinen P, Zarkada G, Zheng W, Robciuc MR, Alitalo K. VEGF-C is required for intestinal lymphatic vessel maintenance and lipid absorption. Embo Molecular Medicine. 7: 1418-25. PMID 26459520 DOI: 10.15252/emmm.201505731  0.32
2015 Choe K, Jang JY, Park I, Kim Y, Ahn S, Park DY, Hong YK, Alitalo K, Koh GY, Kim P. Intravital imaging of intestinal lacteals unveils lipid drainage through contractility. The Journal of Clinical Investigation. PMID 26436648 DOI: 10.1172/JCI76509  0.32
2015 Holopainen T, Räsänen M, Anisimov A, Tuomainen T, Zheng W, Tvorogov D, Hulmi JJ, Andersson LC, Cenni B, Tavi P, Mervaala E, Kivelä R, Alitalo K. Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling. Proceedings of the National Academy of Sciences of the United States of America. 112: 13063-8. PMID 26430242 DOI: 10.1073/pnas.1517810112  0.32
2015 Tamminen K, Balboa D, Toivonen S, Pakarinen MP, Wiener Z, Alitalo K, Otonkoski T. Intestinal Commitment and Maturation of Human Pluripotent Stem Cells Is Independent of Exogenous FGF4 and R-spondin1. Plos One. 10: e0134551. PMID 26230325 DOI: 10.1371/journal.pone.0134551  0.32
2015 Aspelund A, Antila S, Proulx ST, Karlsen TV, Karaman S, Detmar M, Wiig H, Alitalo K. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. The Journal of Experimental Medicine. 212: 991-9. PMID 26077718 DOI: 10.1084/jem.20142290  0.32
2015 Jernman J, Kallio P, Hagström J, Välimäki MJ, Haapasalo H, Alitalo K, Arola J, Haglund C. PROX1 is involved in progression of rectal neuroendocrine tumors, NETs. Virchows Archiv : An International Journal of Pathology. PMID 26063416 DOI: 10.1007/s00428-015-1795-7  0.32
2015 Theelen TL, Lappalainen JP, Sluimer JC, Gurzeler E, Cleutjens JP, Gijbels MJ, Biessen EA, Daemen MJ, Alitalo K, Ylä-Herttuala S. Angiopoietin-2 blocking antibodies reduce early atherosclerotic plaque development in mice. Atherosclerosis. 241: 297-304. PMID 26062989 DOI: 10.1016/j.atherosclerosis.2015.05.018  0.32
2015 Turkki R, Linder N, Holopainen T, Wang Y, Grote A, Lundin M, Alitalo K, Lundin J. Assessment of tumour viability in human lung cancer xenografts with texture-based image analysis. Journal of Clinical Pathology. 68: 614-21. PMID 26021331 DOI: 10.1136/jclinpath-2015-202888  0.32
2015 Visuri MT, Honkonen KM, Hartiala P, Tervala TV, Halonen PJ, Junkkari H, Knuutinen N, Ylä-Herttuala S, Alitalo KK, Saarikko AM. VEGF-C and VEGF-C156S in the pro-lymphangiogenic growth factor therapy of lymphedema: a large animal study. Angiogenesis. 18: 313-26. PMID 26018927 DOI: 10.1007/s10456-015-9469-2  0.32
2015 Syrjälä SO, Nykänen AI, Tuuminen R, Raissadati A, Keränen MA, Arnaudova R, Krebs R, Koh GY, Alitalo K, Lemström KB. Donor Heart Treatment With COMP-Ang1 Limits Ischemia-Reperfusion Injury and Rejection of Cardiac Allografts. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 15: 2075-84. PMID 25932532 DOI: 10.1111/ajt.13296  0.32
2015 Simons M, Alitalo K, Annex BH, Augustin HG, Beam C, Berk BC, Byzova T, Carmeliet P, Chilian W, Cooke JP, Davis GE, Eichmann A, Iruela-Arispe ML, Keshet E, Sinusas AJ, et al. State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A Scientific Statement From the American Heart Association. Circulation Research. 116: e99-132. PMID 25931450 DOI: 10.1161/RES.0000000000000054  0.32
2015 Roukens MG, Peterson-Maduro J, Padberg Y, Jeltsch M, Leppänen VM, Bos FL, Alitalo K, Schulte-Merker S, Schulte D. Functional Dissection of the CCBE1 Protein: A Crucial Requirement for the Collagen Repeat Domain. Circulation Research. 116: 1660-9. PMID 25814692 DOI: 10.1161/CIRCRESAHA.116.304949  0.32
2015 Tatti O, Gucciardo E, Pekkonen P, Holopainen T, Louhimo R, Repo P, Maliniemi P, Lohi J, Rantanen V, Hautaniemi S, Alitalo K, Ranki A, Ojala PM, Keski-Oja J, Lehti K. MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma. Cancer Research. 75: 2083-94. PMID 25808867 DOI: 10.1158/0008-5472.CAN-14-1923  0.32
2015 Tervala TV, Hartiala P, Tammela T, Visuri MT, Ylä-Herttuala S, Alitalo K, Saarikko AM. Growth factor therapy and lymph node graft for lymphedema. The Journal of Surgical Research. 196: 200-7. PMID 25777822 DOI: 10.1016/j.jss.2015.02.031  0.32
2015 Stanczuk L, Martinez-Corral I, Ulvmar MH, Zhang Y, Laviña B, Fruttiger M, Adams RH, Saur D, Betsholtz C, Ortega S, Alitalo K, Graupera M, Mäkinen T. cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels. Cell Reports. PMID 25772358 DOI: 10.1016/j.celrep.2015.02.026  0.32
2015 Martinez-Corral I, Ulvmar MH, Stanczuk L, Tatin F, Kizhatil K, John SW, Alitalo K, Ortega S, Makinen T. Nonvenous origin of dermal lymphatic vasculature. Circulation Research. 116: 1649-54. PMID 25737499 DOI: 10.1161/CIRCRESAHA.116.306170  0.32
2015 Han J, Calvo CF, Kang TH, Baker KL, Park JH, Parras C, Levittas M, Birba U, Pibouin-Fragner L, Fragner P, Bilguvar K, Duman RS, Nurmi H, Alitalo K, Eichmann AC, et al. Vascular endothelial growth factor receptor 3 controls neural stem cell activation in mice and humans. Cell Reports. 10: 1158-72. PMID 25704818 DOI: 10.1016/j.celrep.2015.01.049  0.32
2015 Karaman S, Hollmén M, Robciuc MR, Alitalo A, Nurmi H, Morf B, Buschle D, Alkan HF, Ochsenbein AM, Alitalo K, Wolfrum C, Detmar M. Blockade of VEGF-C and VEGF-D modulates adipose tissue inflammation and improves metabolic parameters under high-fat diet. Molecular Metabolism. 4: 93-105. PMID 25685697 DOI: 10.1016/j.molmet.2014.11.006  0.32
2015 Hakanpaa L, Sipila T, Leppanen VM, Gautam P, Nurmi H, Jacquemet G, Eklund L, Ivaska J, Alitalo K, Saharinen P. Endothelial destabilization by angiopoietin-2 via integrin β1 activation. Nature Communications. 6: 5962. PMID 25635707 DOI: 10.1038/ncomms6962  0.32
2015 Zarkada G, Heinolainen K, Makinen T, Kubota Y, Alitalo K. VEGFR3 does not sustain retinal angiogenesis without VEGFR2. Proceedings of the National Academy of Sciences of the United States of America. 112: 761-6. PMID 25561555 DOI: 10.1073/pnas.1423278112  0.32
2015 Dashkevich A, Raissadati A, Syrjälä SO, Zarkada G, Keränen MAI, Tuuminen R, Krebs R, Anisimov A, Jeltsch M, Leppänen VM, Alitalo K, Nykänen AI, Lemström KB. Ischemia-Reperfusion Injury Enhances Lymphatic Endothelial VEGFR3 and Rejection in Cardiac Allografts American Journal of Transplantation. DOI: 10.1111/ajt.13564  0.32
2015 Saharinen P, Jeltsch M, Santoyo MM, Leppänen VM, Alitalo K. The TIE receptor family Receptor Tyrosine Kinases: Family and Subfamilies. 743-775. DOI: 10.1007/978-3-319-11888-8_16  0.32
2014 Wiener Z, Högström J, Hyvönen V, Band A, Kallio P, Holopainen T, Dufva O, Haglund C, Kruuna O, Oliver G, Ben-Neriah Y, Alitalo K. [Prox1 promotes expansion of the colorectal cancer stem cell population to fuel tumor growth and ischemia resistance]. Duodecim; LääKetieteellinen Aikakauskirja. 130: 2208. PMID 25582015  0.32
2014 Chen HI, Sharma B, Akerberg BN, Numi HJ, Kivelä R, Saharinen P, Aghajanian H, McKay AS, Bogard PE, Chang AH, Jacobs AH, Epstein JA, Stankunas K, Alitalo K, Red-Horse K. The sinus venosus contributes to coronary vasculature through VEGFC-stimulated angiogenesis. Development (Cambridge, England). 141: 4500-12. PMID 25377552 DOI: 10.1242/dev.113639  0.32
2014 Schroedl F, Kaser-Eichberger A, Schlereth SL, Bock F, Regenfuss B, Reitsamer HA, Lutty GA, Maruyama K, Chen L, Lütjen-Drecoll E, Dana R, Kerjaschki D, Alitalo K, De Stefano ME, Junghans BM, et al. Consensus statement on the immunohistochemical detection of ocular lymphatic vessels. Investigative Ophthalmology & Visual Science. 55: 6440-2. PMID 25315233 DOI: 10.1167/iovs.14-15638  0.32
2014 Srinivasan RS, Escobedo N, Yang Y, Interiano A, Dillard ME, Finkelstein D, Mukatira S, Gil HJ, Nurmi H, Alitalo K, Oliver G. The Prox1-Vegfr3 feedback loop maintains the identity and the number of lymphatic endothelial cell progenitors. Genes & Development. 28: 2175-87. PMID 25274728 DOI: 10.1101/gad.216226.113  0.32
2014 Chen HI, Poduri A, Numi H, Kivela R, Saharinen P, McKay AS, Raftrey B, Churko J, Tian X, Zhou B, Wu JC, Alitalo K, Red-Horse K. VEGF-C and aortic cardiomyocytes guide coronary artery stem development. The Journal of Clinical Investigation. 124: 4899-914. PMID 25271623 DOI: 10.1172/JCI77483  0.32
2014 Wiener Z, Högström J, Hyvönen V, Band AM, Kallio P, Holopainen T, Dufva O, Haglund C, Kruuna O, Oliver G, Ben-Neriah Y, Alitalo K. Prox1 promotes expansion of the colorectal cancer stem cell population to fuel tumor growth and ischemia resistance. Cell Reports. 8: 1943-56. PMID 25242330 DOI: 10.1016/j.celrep.2014.08.034  0.32
2014 Niemi H, Honkonen K, Korpisalo P, Huusko J, Kansanen E, Merentie M, Rissanen TT, André H, Pereira T, Poellinger L, Alitalo K, Ylä-Herttuala S. HIF-1α and HIF-2α induce angiogenesis and improve muscle energy recovery. European Journal of Clinical Investigation. 44: 989-99. PMID 25208310 DOI: 10.1111/eci.12333  0.32
2014 Dijkstra MH, Pirinen E, Huusko J, Kivelä R, Schenkwein D, Alitalo K, Ylä-Herttuala S. Lack of cardiac and high-fat diet induced metabolic phenotypes in two independent strains of Vegf-b knockout mice. Scientific Reports. 4: 6238. PMID 25168313 DOI: 10.1038/srep06238  0.32
2014 Aspelund A, Tammela T, Antila S, Nurmi H, Leppänen VM, Zarkada G, Stanczuk L, Francois M, Mäkinen T, Saharinen P, Immonen I, Alitalo K. The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel. The Journal of Clinical Investigation. 124: 3975-86. PMID 25061878 DOI: 10.1172/JCI75395  0.32
2014 Park DY, Lee J, Park I, Choi D, Lee S, Song S, Hwang Y, Hong KY, Nakaoka Y, Makinen T, Kim P, Alitalo K, Hong YK, Koh GY. Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity. The Journal of Clinical Investigation. 124: 3960-74. PMID 25061877 DOI: 10.1172/JCI75392  0.32
2014 Zheng W, Nurmi H, Appak S, Sabine A, Bovay E, Korhonen EA, Orsenigo F, Lohela M, D'Amico G, Holopainen T, Leow CC, Dejana E, Petrova TV, Augustin HG, Alitalo K. Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions. Genes & Development. 28: 1592-603. PMID 25030698 DOI: 10.1101/gad.237677.114  0.32
2014 Bry M, Kivelä R, Leppänen VM, Alitalo K. Vascular endothelial growth factor-B in physiology and disease. Physiological Reviews. 94: 779-94. PMID 24987005 DOI: 10.1152/physrev.00028.2013  0.32
2014 Wiener Z, Band AM, Kallio P, Högström J, Hyvönen V, Kaijalainen S, Ritvos O, Haglund C, Kruuna O, Robine S, Louvard D, Ben-Neriah Y, Alitalo K. Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-β. Proceedings of the National Academy of Sciences of the United States of America. 111: E2229-36. PMID 24825889 DOI: 10.1073/pnas.1406444111  0.32
2014 Vuorio T, Nurmi H, Moulton K, Kurkipuro J, Robciuc MR, Ohman M, Heinonen SE, Samaranayake H, Heikura T, Alitalo K, Ylä-Herttuala S. Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 1162-70. PMID 24723556 DOI: 10.1161/ATVBAHA.114.302528  0.32
2014 Syrjälä SO, Tuuminen R, Nykänen AI, Raissadati A, Dashkevich A, Keränen MA, Arnaudova R, Krebs R, Leow CC, Saharinen P, Alitalo K, Lemström KB. Angiopoietin-2 inhibition prevents transplant ischemia-reperfusion injury and chronic rejection in rat cardiac allografts. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 14: 1096-108. PMID 24708486 DOI: 10.1111/ajt.12672  0.32
2014 Zheng W, Aspelund A, Alitalo K. Lymphangiogenic factors, mechanisms, and applications. The Journal of Clinical Investigation. 124: 878-87. PMID 24590272 DOI: 10.1172/JCI71603  0.32
2014 Jeltsch M, Jha SK, Tvorogov D, Anisimov A, Leppänen VM, Holopainen T, Kivelä R, Ortega S, Kärpanen T, Alitalo K. CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation. Circulation. 129: 1962-71. PMID 24552833 DOI: 10.1161/CIRCULATIONAHA.113.002779  0.32
2014 Kivelä R, Bry M, Robciuc MR, Räsänen M, Taavitsainen M, Silvola JM, Saraste A, Hulmi JJ, Anisimov A, Mäyränpää MI, Lindeman JH, Eklund L, Hellberg S, Hlushchuk R, Zhuang ZW, ... ... Alitalo K, et al. VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart. Embo Molecular Medicine. 6: 307-21. PMID 24448490 DOI: 10.1002/emmm.201303147  0.32
2014 D'Amico G, Korhonen EA, Anisimov A, Zarkada G, Holopainen T, Hägerling R, Kiefer F, Eklund L, Sormunen R, Elamaa H, Brekken RA, Adams RH, Koh GY, Saharinen P, Alitalo K. Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy. The Journal of Clinical Investigation. 124: 824-34. PMID 24430181 DOI: 10.1172/JCI68897  0.32
2014 Yao LC, Testini C, Tvorogov D, Anisimov A, Vargas SO, Baluk P, Pytowski B, Claesson-Welsh L, Alitalo K, McDonald DM. Pulmonary lymphangiectasia resulting from vascular endothelial growth factor-C overexpression during a critical period. Circulation Research. 114: 806-22. PMID 24429550 DOI: 10.1161/CIRCRESAHA.114.303119  0.32
2014 Nieminen T, Toivanen PI, Rintanen N, Heikura T, Jauhiainen S, Airenne KJ, Alitalo K, Marjomäki V, Ylä-Herttuala S. The impact of the receptor binding profiles of the vascular endothelial growth factors on their angiogenic features. Biochimica Et Biophysica Acta. 1840: 454-63. PMID 24112971 DOI: 10.1016/j.bbagen.2013.10.005  0.32
2013 Raissadati A, Jokinen JJ, Syrjälä SO, Keränen MA, Krebs R, Tuuminen R, Arnaudova R, Rouvinen E, Anisimov A, Soronen J, Pajusola K, Alitalo K, Nykänen AI, Lemström K. Ex vivo intracoronary gene transfer of adeno-associated virus 2 leads to superior transduction over serotypes 8 and 9 in rat heart transplants. Transplant International : Official Journal of the European Society For Organ Transplantation. 26: 1126-37. PMID 24102821 DOI: 10.1111/tri.12182  0.32
2013 Kwon HB, Fukuhara S, Asakawa K, Ando K, Kashiwada T, Kawakami K, Hibi M, Kwon YG, Kim KW, Alitalo K, Mochizuki N. The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc/Vegfr3 signaling in zebrafish. Development (Cambridge, England). 140: 4081-90. PMID 24046321 DOI: 10.1242/dev.091702  0.32
2013 Jeltsch M, Leppänen VM, Saharinen P, Alitalo K. Receptor tyrosine kinase-mediated angiogenesis. Cold Spring Harbor Perspectives in Biology. 5. PMID 24003209 DOI: 10.1101/cshperspect.a009183  0.32
2013 Pribluda A, Elyada E, Wiener Z, Hamza H, Goldstein RE, Biton M, Burstain I, Morgenstern Y, Brachya G, Billauer H, Biton S, Snir-Alkalay I, Vucic D, Schlereth K, Mernberger M, ... ... Alitalo K, et al. A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism. Cancer Cell. 24: 242-56. PMID 23890787 DOI: 10.1016/j.ccr.2013.06.005  0.32
2013 Leppänen VM, Tvorogov D, Kisko K, Prota AE, Jeltsch M, Anisimov A, Markovic-Mueller S, Stuttfeld E, Goldie KN, Ballmer-Hofer K, Alitalo K. Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation. Proceedings of the National Academy of Sciences of the United States of America. 110: 12960-5. PMID 23878260 DOI: 10.1073/pnas.1301415110  0.32
2013 Kim M, Park HJ, Seol JW, Jang JY, Cho YS, Kim KR, Choi Y, Lydon JP, Demayo FJ, Shibuya M, Ferrara N, Sung HK, Nagy A, Alitalo K, Koh GY. VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy. Embo Molecular Medicine. 5: 1415-30. PMID 23853117 DOI: 10.1002/emmm.201302618  0.32
2013 Anisimov A, Leppänen VM, Tvorogov D, Zarkada G, Jeltsch M, Holopainen T, Kaijalainen S, Alitalo K. The basis for the distinct biological activities of vascular endothelial growth factor receptor-1 ligands. Science Signaling. 6: ra52. PMID 23821770 DOI: 10.1126/scisignal.2003905  0.32
2013 Gaál EI, Tammela T, Anisimov A, Marbacher S, Honkanen P, Zarkada G, Leppänen VM, Tatlisumak T, Hernesniemi J, Niemelä M, Alitalo K. Comparison of vascular growth factors in the murine brain reveals placenta growth factor as prime candidate for CNS revascularization. Blood. 122: 658-65. PMID 23803710 DOI: 10.1182/blood-2012-07-441527  0.32
2013 Kerkelä R, Karsikas S, Szabo Z, Serpi R, Magga J, Gao E, Alitalo K, Anisimov A, Sormunen R, Pietilä I, Vainio L, Koch WJ, Kivirikko KI, Myllyharju J, Koivunen P. Activation of hypoxia response in endothelial cells contributes to ischemic cardioprotection. Molecular and Cellular Biology. 33: 3321-9. PMID 23775121 DOI: 10.1128/MCB.00432-13  0.32
2013 Wiig H, Schröder A, Neuhofer W, Jantsch J, Kopp C, Karlsen TV, Boschmann M, Goss J, Bry M, Rakova N, Dahlmann A, Brenner S, Tenstad O, Nurmi H, Mervaala E, ... ... Alitalo K, et al. Immune cells control skin lymphatic electrolyte homeostasis and blood pressure. The Journal of Clinical Investigation. 123: 2803-15. PMID 23722907 DOI: 10.1172/JCI60113  0.32
2013 Tuppurainen L, Sallinen H, Kokki E, Koponen J, Anttila M, Pulkkinen K, Heikura T, Toivanen P, Hämäläinen K, Kosma VM, Heinonen S, Alitalo K, Ylä-Herttuala S. Preclinical safety, toxicology, and biodistribution study of adenoviral gene therapy with sVEGFR-2 and sVEGFR-3 combined with chemotherapy for ovarian cancer. Human Gene Therapy. Clinical Development. 24: 29-37. PMID 23692381 DOI: 10.1089/humc.2013.006  0.32
2013 Hamm A, Veschini L, Takeda Y, Costa S, Delamarre E, Squadrito ML, Henze AT, Wenes M, Serneels J, Pucci F, Roncal C, Anisimov A, Alitalo K, De Palma M, Mazzone M. PHD2 regulates arteriogenic macrophages through TIE2 signalling. Embo Molecular Medicine. 5: 843-57. PMID 23616286 DOI: 10.1002/emmm.201302695  0.32
2013 Eklund L, Bry M, Alitalo K. Mouse models for studying angiogenesis and lymphangiogenesis in cancer. Molecular Oncology. 7: 259-82. PMID 23522958 DOI: 10.1016/j.molonc.2013.02.007  0.32
2013 Thomas JL, Baker K, Han J, Calvo C, Nurmi H, Eichmann AC, Alitalo K. Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells. Cellular and Molecular Life Sciences : Cmls. 70: 1779-92. PMID 23479133 DOI: 10.1007/s00018-013-1312-6  0.32
2013 Villefranc JA, Nicoli S, Bentley K, Jeltsch M, Zarkada G, Moore JC, Gerhardt H, Alitalo K, Lawson ND. A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development. Development (Cambridge, England). 140: 1497-506. PMID 23462469 DOI: 10.1242/dev.084152  0.32
2013 Baluk P, Hogmalm A, Bry M, Alitalo K, Bry K, McDonald DM. Transgenic overexpression of interleukin-1β induces persistent lymphangiogenesis but not angiogenesis in mouse airways. The American Journal of Pathology. 182: 1434-47. PMID 23391392 DOI: 10.1016/j.ajpath.2012.12.003  0.32
2013 Anisimov A, Tvorogov D, Alitalo A, Leppänen VM, An Y, Han EC, Orsenigo F, Gaál EI, Holopainen T, Koh YJ, Tammela T, Korpisalo P, Keskitalo S, Jeltsch M, Ylä-Herttuala S, ... ... Alitalo K, et al. Vascular endothelial growth factor-angiopoietin chimera with improved properties for therapeutic angiogenesis. Circulation. 127: 424-34. PMID 23357661 DOI: 10.1161/CIRCULATIONAHA.112.127472  0.32
2013 Hägerling R, Pollmann C, Andreas M, Schmidt C, Nurmi H, Adams RH, Alitalo K, Andresen V, Schulte-Merker S, Kiefer F. A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy. The Embo Journal. 32: 629-44. PMID 23299940 DOI: 10.1038/emboj.2012.340  0.32
2013 Markhus CE, Karlsen TV, Wagner M, Wagner M, Svendsen ØS, Tenstad O, Alitalo K, Wiig H. Increased interstitial protein because of impaired lymph drainage does not induce fibrosis and inflammation in lymphedema. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 266-74. PMID 23288156 DOI: 10.1161/ATVBAHA.112.300384  0.32
2013 Honkonen KM, Visuri MT, Tervala TV, Halonen PJ, Koivisto M, Lähteenvuo MT, Alitalo KK, Ylä-Herttuala S, Saaristo AM. Lymph node transfer and perinodal lymphatic growth factor treatment for lymphedema. Annals of Surgery. 257: 961-7. PMID 23013803 DOI: 10.1097/SLA.0b013e31826ed043  0.32
2013 Partanen TA, Vuola P, Jauhiainen S, Lohi J, Salminen P, Pitkäranta A, Häkkinen SK, Honkonen K, Alitalo K, Ylä-Herttuala S. Neuropilin-2 and vascular endothelial growth factor receptor-3 are up-regulated in human vascular malformations. Angiogenesis. 16: 137-46. PMID 22961441 DOI: 10.1007/s10456-012-9305-x  0.32
2013 Alitalo K, VanHook AM. Science signaling Podcast: 2 july 2013 Science Signaling. 6. DOI: 10.1126/scisignal.2004435  0.32
2012 Huusko J, Lottonen L, Merentie M, Gurzeler E, Anisimov A, Miyanohara A, Alitalo K, Tavi P, Ylä-Herttuala S. AAV9-mediated VEGF-B gene transfer improves systolic function in progressive left ventricular hypertrophy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 2212-21. PMID 23089731 DOI: 10.1038/mt.2012.145  0.32
2012 Robciuc MR, Skrobuk P, Anisimov A, Olkkonen VM, Alitalo K, Eckel RH, Koistinen HA, Jauhiainen M, Ehnholm C. Angiopoietin-like 4 mediates PPAR delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubes. Plos One. 7: e46212. PMID 23056264 DOI: 10.1371/journal.pone.0046212  0.32
2012 Alitalo K. A radical view of pathological vasculature. Cell Metabolism. 16: 287-8. PMID 22958916 DOI: 10.1016/j.cmet.2012.08.008  0.32
2012 Leite de Oliveira R, Deschoemaeker S, Henze AT, Debackere K, Finisguerra V, Takeda Y, Roncal C, Dettori D, Tack E, Jönsson Y, Veschini L, Peeters A, Anisimov A, Hofmann M, Alitalo K, et al. Gene-targeting of Phd2 improves tumor response to chemotherapy and prevents side-toxicity. Cancer Cell. 22: 263-77. PMID 22897855 DOI: 10.1016/j.ccr.2012.06.028  0.32
2012 Thomas SN, Rutkowski JM, Pasquier M, Kuan EL, Alitalo K, Randolph GJ, Swartz MA. Impaired humoral immunity and tolerance in K14-VEGFR-3-Ig mice that lack dermal lymphatic drainage. Journal of Immunology (Baltimore, Md. : 1950). 189: 2181-90. PMID 22844119 DOI: 10.4049/jimmunol.1103545  0.32
2012 Larrieu-Lahargue F, Welm AL, Bouchecareilh M, Alitalo K, Li DY, Bikfalvi A, Auguste P. Blocking Fibroblast Growth Factor receptor signaling inhibits tumor growth, lymphangiogenesis, and metastasis. Plos One. 7: e39540. PMID 22761819 DOI: 10.1371/journal.pone.0039540  0.32
2012 Keuschnigg J, Tvorogov D, Elima K, Salmi M, Alitalo K, Salminen T, Jalkanen S. PV-1 is recognized by the PAL-E antibody and forms complexes with NRP-1. Blood. 120: 232-5. PMID 22627768 DOI: 10.1182/blood-2012-01-406876  0.32
2012 Mirza M, Pang MF, Zaini MA, Haiko P, Tammela T, Alitalo K, Philipson L, Fuxe J, Sollerbrant K. Essential role of the coxsackie- and adenovirus receptor (CAR) in development of the lymphatic system in mice. Plos One. 7: e37523. PMID 22624044 DOI: 10.1371/journal.pone.0037523  0.32
2012 Holopainen T, López-Alpuche V, Zheng W, Heljasvaara R, Jones D, He Y, Tvorogov D, D'Amico G, Wiener Z, Andersson LC, Pihlajaniemi T, Min W, Alitalo K. Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth. Cancer Research. 72: 3512-21. PMID 22593188 DOI: 10.1158/0008-5472.CAN-11-1070  0.32
2012 Meinecke AK, Nagy N, Lago GD, Kirmse S, Klose R, Schrödter K, Zimmermann A, Helfrich I, Rundqvist H, Theegarten D, Anhenn O, Orian-Rousseau V, Johnson RS, Alitalo K, Fischer JW, et al. Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis. Blood. 119: 5931-42. PMID 22547584 DOI: 10.1182/blood-2011-12-396895  0.32
2012 Martínez-Corral I, Olmeda D, Diéguez-Hurtado R, Tammela T, Alitalo K, Ortega S. In vivo imaging of lymphatic vessels in development, wound healing, inflammation, and tumor metastasis. Proceedings of the National Academy of Sciences of the United States of America. 109: 6223-8. PMID 22474390 DOI: 10.1073/pnas.1115542109  0.32
2012 Pietilä R, Nätynki M, Tammela T, Kangas J, Pulkki KH, Limaye N, Vikkula M, Koh GY, Saharinen P, Alitalo K, Eklund L. Ligand oligomerization state controls Tie2 receptor trafficking and angiopoietin-2-specific responses. Journal of Cell Science. 125: 2212-23. PMID 22357955 DOI: 10.1242/jcs.098020  0.32
2012 Holopainen T, Saharinen P, D'Amico G, Lampinen A, Eklund L, Sormunen R, Anisimov A, Zarkada G, Lohela M, Heloterä H, Tammela T, Benjamin LE, Ylä-Herttuala S, Leow CC, Koh GY, ... Alitalo K, et al. Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis. Journal of the National Cancer Institute. 104: 461-75. PMID 22343031 DOI: 10.1093/jnci/djs009  0.32
2012 Sopo M, Anttila M, Sallinen H, Tuppurainen L, Laurema A, Laidinen S, Hamalainen K, Tuunanen P, Koponen JK, Kosma VM, Heinonen S, Alitalo K, Yla-Herttuala S. Antiangiogenic gene therapy with soluble VEGF-receptors -1, -2 and -3 together with paclitaxel prolongs survival of mice with human ovarian carcinoma. International Journal of Cancer. Journal International Du Cancer. 131: 2394-401. PMID 22336998 DOI: 10.1002/ijc.27495  0.32
2012 Weltner J, Anisimov A, Alitalo K, Otonkoski T, Trokovic R. Induced pluripotent stem cell clones reprogrammed via recombinant adeno-associated virus-mediated transduction contain integrated vector sequences. Journal of Virology. 86: 4463-7. PMID 22301147 DOI: 10.1128/JVI.06302-11  0.32
2012 Brozzo MS, Bjeli? S, Kisko K, Schleier T, Leppänen VM, Alitalo K, Winkler FK, Ballmer-Hofer K. Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization. Blood. 119: 1781-8. PMID 22207738 DOI: 10.1182/blood-2011-11-390922  0.32
2011 Cheng F, Pekkonen P, Laurinavicius S, Sugiyama N, Henderson S, Günther T, Rantanen V, Kaivanto E, Aavikko M, Sarek G, Hautaniemi S, Biberfeld P, Aaltonen L, Grundhoff A, Boshoff C, ... Alitalo K, et al. KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition. Cell Host & Microbe. 10: 577-90. PMID 22177562 DOI: 10.1016/j.chom.2011.10.011  0.32
2011 Alitalo K. The lymphatic vasculature in disease. Nature Medicine. 17: 1371-80. PMID 22064427 DOI: 10.1038/nm.2545  0.32
2011 Takeda Y, Costa S, Delamarre E, Roncal C, Leite de Oliveira R, Squadrito ML, Finisguerra V, Deschoemaeker S, Bruyère F, Wenes M, Hamm A, Serneels J, Magat J, Bhattacharyya T, Anisimov A, ... ... Alitalo K, et al. Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis. Nature. 479: 122-6. PMID 21983962 DOI: 10.1038/nature10507  0.32
2011 Skog M, Bono P, Lundin M, Lundin J, Louhimo J, Linder N, Petrova TV, Andersson LC, Joensuu H, Alitalo K, Haglund CH. Expression and prognostic value of transcription factor PROX1 in colorectal cancer. British Journal of Cancer. 105: 1346-51. PMID 21970873 DOI: 10.1038/bjc.2011.297  0.32
2011 Tammela T, Zarkada G, Nurmi H, Jakobsson L, Heinolainen K, Tvorogov D, Zheng W, Franco CA, Murtomäki A, Aranda E, Miura N, Ylä-Herttuala S, Fruttiger M, Mäkinen T, Eichmann A, ... ... Alitalo K, et al. VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nature Cell Biology. 13: 1202-13. PMID 21909098 DOI: 10.1038/ncb2331  0.32
2011 Piltonen M, Planken A, Leskelä O, Myöhänen TT, Hänninen AL, Auvinen P, Alitalo K, Andressoo JO, Saarma M, Männistö PT. Vascular endothelial growth factor C acts as a neurotrophic factor for dopamine neurons in vitro and in vivo. Neuroscience. 192: 550-63. PMID 21767614 DOI: 10.1016/j.neuroscience.2011.06.084  0.32
2011 Ruiz de Almodovar C, Fabre PJ, Knevels E, Coulon C, Segura I, Haddick PC, Aerts L, Delattin N, Strasser G, Oh WJ, Lange C, Vinckier S, Haigh J, Fouquet C, Gu C, ... Alitalo K, et al. VEGF mediates commissural axon chemoattraction through its receptor Flk1. Neuron. 70: 966-78. PMID 21658588 DOI: 10.1016/j.neuron.2011.04.014  0.32
2011 Kisko K, Brozzo MS, Missimer J, Schleier T, Menzel A, Leppänen VM, Alitalo K, Walzthoeni T, Aebersold R, Ballmer-Hofer K. Structural analysis of vascular endothelial growth factor receptor-2/ligand complexes by small-angle X-ray solution scattering. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 2980-6. PMID 21613573 DOI: 10.1096/fj.11-185397  0.32
2011 Saharinen P, Alitalo K. The yin, the yang, and the angiopoietin-1. The Journal of Clinical Investigation. 121: 2157-9. PMID 21606600 DOI: 10.1172/JCI58196  0.32
2011 Zheng W, Tammela T, Yamamoto M, Anisimov A, Holopainen T, Kaijalainen S, Karpanen T, Lehti K, Ylä-Herttuala S, Alitalo K. Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor. Blood. 118: 1154-62. PMID 21566091 DOI: 10.1182/blood-2010-11-317800  0.32
2011 Kerjaschki D, Bago-Horvath Z, Rudas M, Sexl V, Schneckenleithner C, Wolbank S, Bartel G, Krieger S, Kalt R, Hantusch B, Keller T, Nagy-Bojarszky K, Huttary N, Raab I, Lackner K, ... ... Alitalo K, et al. Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse. The Journal of Clinical Investigation. 121: 2000-12. PMID 21540548 DOI: 10.1172/JCI44751  0.32
2011 Calvo CF, Fontaine RH, Soueid J, Tammela T, Makinen T, Alfaro-Cervello C, Bonnaud F, Miguez A, Benhaim L, Xu Y, Barallobre MJ, Moutkine I, Lyytikkä J, Tatlisumak T, Pytowski B, ... ... Alitalo K, et al. Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis. Genes & Development. 25: 831-44. PMID 21498572 DOI: 10.1101/gad.615311  0.32
2011 Saharinen P, Eklund L, Pulkki K, Bono P, Alitalo K. VEGF and angiopoietin signaling in tumor angiogenesis and metastasis. Trends in Molecular Medicine. 17: 347-62. PMID 21481637 DOI: 10.1016/j.molmed.2011.01.015  0.32
2011 Yang H, Kim C, Kim MJ, Schwendener RA, Alitalo K, Heston W, Kim I, Kim WJ, Koh GY. Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer. Molecular Cancer. 10: 36. PMID 21481239 DOI: 10.1186/1476-4598-10-36  0.32
2011 Holopainen T, Bry M, Alitalo K, Saaristo A. Perspectives on lymphangiogenesis and angiogenesis in cancer. Journal of Surgical Oncology. 103: 484-8. PMID 21480240 DOI: 10.1002/jso.21808  0.32
2011 Gottar-Guillier M, Dodeller F, Huesken D, Iourgenko V, Mickanin C, Labow M, Gaveriaux S, Kinzel B, Mueller M, Alitalo K, Littlewood-Evans A, Cenni B. The tyrosine kinase BMX is an essential mediator of inflammatory arthritis in a kinase-independent manner. Journal of Immunology (Baltimore, Md. : 1950). 186: 6014-23. PMID 21471444 DOI: 10.4049/jimmunol.1002813  0.32
2011 Norrmén C, Tammela T, Petrova TV, Alitalo K. Biological basis of therapeutic lymphangiogenesis. Circulation. 123: 1335-51. PMID 21444892 DOI: 10.1161/CIRCULATIONAHA.107.704098  0.32
2011 Hussein SM, Batada NN, Vuoristo S, Ching RW, Autio R, Närvä E, Ng S, Sourour M, Hämäläinen R, Olsson C, Lundin K, Mikkola M, Trokovic R, Peitz M, Brüstle O, ... ... Alitalo K, et al. Copy number variation and selection during reprogramming to pluripotency. Nature. 471: 58-62. PMID 21368824 DOI: 10.1038/nature09871  0.32
2011 Huggenberger R, Siddiqui SS, Brander D, Ullmann S, Zimmermann K, Antsiferova M, Werner S, Alitalo K, Detmar M. An important role of lymphatic vessel activation in limiting acute inflammation. Blood. 117: 4667-78. PMID 21364190 DOI: 10.1182/blood-2010-10-316356  0.32
2011 Elyada E, Pribluda A, Goldstein RE, Morgenstern Y, Brachya G, Cojocaru G, Snir-Alkalay I, Burstain I, Haffner-Krausz R, Jung S, Wiener Z, Alitalo K, Oren M, Pikarsky E, Ben-Neriah Y. CKIα ablation highlights a critical role for p53 in invasiveness control. Nature. 470: 409-13. PMID 21331045 DOI: 10.1038/nature09673  0.32
2011 Hosono K, Suzuki T, Tamaki H, Sakagami H, Hayashi I, Narumiya S, Alitalo K, Majima M. Roles of prostaglandin E2-EP3/EP4 receptor signaling in the enhancement of lymphangiogenesis during fibroblast growth factor-2-induced granulation formation. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 1049-58. PMID 21311040 DOI: 10.1161/ATVBAHA.110.222356  0.32
2011 Tammela T, Saaristo A, Holopainen T, Ylä-Herttuala S, Andersson LC, Virolainen S, Immonen I, Alitalo K. Photodynamic ablation of lymphatic vessels and intralymphatic cancer cells prevents metastasis. Science Translational Medicine. 3: 69ra11. PMID 21307301 DOI: 10.1126/scitranslmed.3001699  0.32
2011 Lähteenvuo M, Honkonen K, Tervala T, Tammela T, Suominen E, Lähteenvuo J, Kholová I, Alitalo K, Ylä-Herttuala S, Saaristo A. Growth factor therapy and autologous lymph node transfer in lymphedema. Circulation. 123: 613-20. PMID 21282502 DOI: 10.1161/CIRCULATIONAHA.110.965384  0.32
2011 Leppänen VM, Jeltsch M, Anisimov A, Tvorogov D, Aho K, Kalkkinen N, Toivanen P, Ylä-Herttuala S, Ballmer-Hofer K, Alitalo K. Structural determinants of vascular endothelial growth factor-D receptor binding and specificity. Blood. 117: 1507-15. PMID 21148085 DOI: 10.1182/blood-2010-08-301549  0.32
2011 Gjini E, Hekking LH, Küchler A, Saharinen P, Wienholds E, Post JA, Alitalo K, Schulte-Merker S. Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity Dmm Disease Models and Mechanisms. 4: 57-66. PMID 21045210 DOI: 10.1242/dmm.005033  0.32
2011 Sallinen H, Anttila M, Gröhn O, Koponen J, Hämäläinen K, Kholova I, Kosma VM, Heinonen S, Alitalo K, Ylä-Herttuala S. Cotargeting of VEGFR-1 and -3 and angiopoietin receptor Tie2 reduces the growth of solid human ovarian cancer in mice Cancer Gene Therapy. 18: 100-109. PMID 20865022 DOI: 10.1038/cgt.2010.56  0.32
2011 Norrmén C, Tammela T, Alitalo K, Petrova TV. Response to letter regarding article, "biological basis of therapeutic lymphangiogenesis" Circulation. 124: e896. DOI: 10.1161/CIRCULATIONAHA.111.064907  0.32
2010 Tvorogov D, Anisimov A, Zheng W, Leppänen VM, Tammela T, Laurinavicius S, Holnthoner W, Heloterä H, Holopainen T, Jeltsch M, Kalkkinen N, Lankinen H, Ojala PM, Alitalo K. Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization. Cancer Cell. 18: 630-40. PMID 21130043 DOI: 10.1016/j.ccr.2010.11.001  0.32
2010 Albrecht I, Kopfstein L, Strittmatter K, Schomber T, Falkevall A, Hagberg CE, Lorentz P, Jeltsch M, Alitalo K, Eriksson U, Christofori G, Pietras K. Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesis. Plos One. 5: e14109. PMID 21124841 DOI: 10.1371/journal.pone.0014109  0.32
2010 Kim M, Koh YJ, Kim KE, Koh BI, Nam DH, Alitalo K, Kim I, Koh GY. CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche Cancer Research. 70: 10411-10421. PMID 21056990 DOI: 10.1158/0008-5472.CAN-10-2591  0.32
2010 Bry M, Kivelä R, Holopainen T, Anisimov A, Tammela T, Soronen J, Silvola J, Saraste A, Jeltsch M, Korpisalo P, Carmeliet P, Lemström KB, Shibuya M, Ylä-Herttuala S, Alhonen L, ... ... Alitalo K, et al. Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation. Circulation. 122: 1725-33. PMID 20937974 DOI: 10.1161/CIRCULATIONAHA.110.957332  0.32
2010 Sugiyama N, Varjosalo M, Meller P, Lohi J, Hyytiäinen M, Kilpinen S, Kallioniemi O, Ingvarsen S, Engelholm LH, Taipale J, Alitalo K, Keski-Oja J, Lehti K. Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation Cancer Research. 70: 7851-7861. PMID 20876804 DOI: 10.1158/0008-5472.CAN-10-1223  0.32
2010 Huggenberger R, Ullmann S, Proulx ST, Pytowski B, Alitalo K, Detmar M. Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation Journal of Experimental Medicine. 207: 2255-2269. PMID 20837699 DOI: 10.1084/jem.20100559  0.32
2010 Sugiyama N, Varjosalo M, Meller P, Lohi J, Chan KM, Zhou Z, Alitalo K, Taipale J, Keski-Oja J, Lehti K. FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase - FGFR4 complex Proceedings of the National Academy of Sciences of the United States of America. 107: 15786-15791. PMID 20798051 DOI: 10.1073/pnas.0914459107  0.32
2010 McBride DJ, Orpana AK, Sotiriou C, Joensuu H, Stephens PJ, Mudie LJ, Hämäläinen E, Stebbings LA, Andersson LC, Flanagan AM, Durbecq V, Ignatiadis M, Kallioniemi O, Heckman CA, Alitalo K, et al. Use of cancer-specific genomic rearrangements to quantify disease burden in plasma from patients with solid tumors. Genes, Chromosomes & Cancer. 49: 1062-9. PMID 20725990 DOI: 10.1002/gcc.20815  0.32
2010 Zhou F, Chang Z, Zhang L, Hong YK, Shen B, Wang B, Zhang F, Lu G, Tvorogov D, Alitalo K, Hemmings BA, Yang Z, He Y. Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development. The American Journal of Pathology. 177: 2124-33. PMID 20724596 DOI: 10.2353/ajpath.2010.091301  0.32
2010 Hermans K, Claes F, Vandevelde W, Zheng W, Geudens I, Orsenigo F, De Smet F, Gjini E, Anthonis K, Ren B, Kerjaschki D, Autiero M, Ny A, Simons M, Dewerchin M, ... ... Alitalo K, et al. Role of synectin in lymphatic development in zebrafish and frogs. Blood. 116: 3356-66. PMID 20631376 DOI: 10.1182/blood-2009-11-254557  0.32
2010 Kim H, Nguyen VP, Petrova TV, Cruz M, Alitalo K, Dumont DJ. Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature Bmc Developmental Biology. 10. PMID 20584329 DOI: 10.1186/1471-213X-10-72  0.32
2010 Keränen MA, Nykänen AI, Krebs R, Pajusola K, Tuuminen R, Alitalo K, Lemström KB. Cardiomyocyte-targeted HIF-1alpha gene therapy inhibits cardiomyocyte apoptosis and cardiac allograft vasculopathy in the rat. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 29: 1058-66. PMID 20580263 DOI: 10.1016/j.healun.2010.05.021  0.32
2010 Saharinen P, Helotera H, Miettinen J, Norrmen C, D'Amico G, Jeltsch M, Langenberg T, Vandevelde W, Ny A, Dewerchin M, Carmeliet P, Alitalo K. Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development Genes and Development. 24: 875-880. PMID 20439428 DOI: 10.1101/gad.565010  0.32
2010 Saharinen P, Bry M, Alitalo K. How do angiopoietins Tie in with vascular endothelial growth factors? Current Opinion in Hematology. 17: 198-205. PMID 20375888 DOI: 10.1097/MOH.0b013e3283386673  0.32
2010 Nykänen AI, Sandelin H, Krebs R, Keränen MA, Tuuminen R, Kärpänen T, Wu Y, Pytowski B, Koskinen PK, Ylä-Herttuala S, Alitalo K, Lemström KB. Targeting lymphatic vessel activation and CCL21 production by vascular endothelial growth factor receptor-3 inhibition has novel immunomodulatory and antiarteriosclerotic effects in cardiac allografts. Circulation. 121: 1413-22. PMID 20231530 DOI: 10.1161/CIRCULATIONAHA.109.910703  0.32
2010 Nilsson I, Bahram F, Li X, Gualandi L, Koch S, Jarvius M, Söderberg O, Anisimov A, Kholová I, Pytowski B, Baldwin M, Ylä-Herttuala S, Alitalo K, Kreuger J, Claesson-Welsh L. VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts Embo Journal. 29: 1377-1388. PMID 20224550 DOI: 10.1038/emboj.2010.30  0.32
2010 Tammela T, Alitalo K. Lymphangiogenesis: Molecular Mechanisms and Future Promise Cell. 140: 460-476. PMID 20178740 DOI: 10.1016/j.cell.2010.01.045  0.32
2010 Leppänen VM, Prota AE, Jeltsch M, Anisimov A, Kalkkinen N, Strandin T, Lankinen H, Goldman A, Ballmer-Hofer K, Alitalo K. Structural determinants of growth factor binding and specificity by VEGF receptor 2 Proceedings of the National Academy of Sciences of the United States of America. 107: 2425-2430. PMID 20145116 DOI: 10.1073/pnas.0914318107  0.32
2010 Uhrin P, Zaujec J, Breuss JM, Olcaydu D, Chrenek P, Stockinger H, Fuertbauer E, Moser M, Haiko P, Fässler R, Alitalo K, Binder BR, Kerjaschki D. Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation. Blood. 115: 3997-4005. PMID 20110424 DOI: 10.1182/blood-2009-04-216069  0.32
2010 Rutkowski JM, Markhus CE, Gyenge CC, Alitalo K, Wiig H, Swartz MA. Dermal collagen and lipid deposition correlate with tissue swelling and hydraulic conductivity in murine primary lymphedema American Journal of Pathology. 176: 1122-1129. PMID 20110415 DOI: 10.2353/ajpath.2010.090733  0.32
2010 Xu Y, Yuan L, Mak J, Pardanaud L, Caunt M, Kasman I, Larrivée B, Del Toro R, Suchting S, Medvinsky A, Silva J, Yang J, Thomas JL, Koch AW, Alitalo K, et al. Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3. The Journal of Cell Biology. 188: 115-30. PMID 20065093 DOI: 10.1083/jcb.200903137  0.32
2010 Norrmén C, Vandevelde W, Ny A, Saharinen P, Gentile M, Haraldsen G, Puolakkainen P, Lukanidin E, Dewerchin M, Alitalo K, Petrova TV. Liprin β1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity Blood. 115: 906-909. PMID 19965622 DOI: 10.1182/blood-2009-03-212274  0.32
2010 D'Amico G, Korhonen EA, Waltari M, Saharinen P, Laakkonen P, Alitalo K. Loss of endothelial tie1 receptor impairs lymphatic vessel development-brief report Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 207-209. PMID 19910638 DOI: 10.1161/ATVBAHA.109.196618  0.32
2010 D'Amico G, Alitalo K. Inside bloody lymphatics Blood. 116: 512-513. DOI: 10.1182/blood-2010-04-278549  0.32
2009 Hogan BM, Herpers R, Witte M, Heloterä H, Alitalo K, Duckers HJ, Schulte-Merker S. Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries Development. 136: 4001-4009. PMID 19906867 DOI: 10.1242/dev.039990  0.32
2009 Mouta-Bellum C, Kirov A, Miceli-Libby L, Mancini ML, Petrova TV, Liaw L, Prudovsky I, Thorpe PE, Miura N, Cantley LC, Alitalo K, Fruman DA, Vary CP. Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 238: 2670-9. PMID 19705443 DOI: 10.1002/dvdy.22078  0.32
2009 Anisimov A, Alitalo A, Korpisalo P, Soronen J, Kaijalainen S, Leppänen VM, Jeltsch M, Ylä-Herttuala S, Alitalo K. Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle Circulation Research. 104: 1302-1312. PMID 19443835 DOI: 10.1161/CIRCRESAHA.109.197830  0.32
2009 MacHnik A, Neuhofer W, Jantsch J, Dahlmann A, Tammela T, MacHura K, Park JK, Beck FX, Müller DN, Derer W, Goss J, Ziomber A, Dietsch P, Wagner H, Van Rooijen N, ... ... Alitalo K, et al. Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism Nature Medicine. 15: 545-552. PMID 19412173 DOI: 10.1038/nm.1960  0.32
2009 Norrmén C, Ivanov KI, Cheng J, Zangger N, Delorenzi M, Jaquet M, Miura N, Puolakkainen P, Horsley V, Hu J, Augustin HG, Ylä-Herttuala S, Alitalo K, Petrova TV. FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1. The Journal of Cell Biology. 185: 439-57. PMID 19398761 DOI: 10.1083/jcb.200901104  0.32
2009 Kataru RP, Jung K, Jang C, Yang H, Schwendener RA, Jung EB, Seung HH, Alitalo K, Gou YK. Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution Blood. 113: 5650-5659. PMID 19346498 DOI: 10.1182/blood-2008-09-176776  0.32
2009 Ghalamkarpour A, Holnthoner W, Saharinen P, Boon LM, Mulliken JB, Alitalo K, Vikkula M. Recessive primary congenital lymphoedema caused by a VEGFR3 mutation Journal of Medical Genetics. 46: 399-404. PMID 19289394 DOI: 10.1136/jmg.2008.064469  0.32
2009 Augustin HG, Koh GY, Thurston G, Alitalo K. Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. Nature Reviews. Molecular Cell Biology. 10: 165-77. PMID 19234476 DOI: 10.1038/nrm2639  0.32
2009 Lohela M, Bry M, Tammela T, Alitalo K. VEGFs and receptors involved in angiogenesis versus lymphangiogenesis Current Opinion in Cell Biology. 21: 154-165. PMID 19230644 DOI: 10.1016/j.ceb.2008.12.012  0.32
2009 Tuuminen R, Nykänen AI, Krebs R, Soronen J, Pajusola K, Keränen MA, Koskinen PK, Alitalo K, Lemström KB. PDGF-A, -C, and -D but not PDGF-B increase TGF-beta1 and chronic rejection in rat cardiac allografts. Arteriosclerosis, Thrombosis, and Vascular Biology. 29: 691-8. PMID 19213942 DOI: 10.1161/ATVBAHA.108.178558  0.32
2009 Lähteenvuo JE, Lähteenvuo MT, Kivelä A, Rosenlew C, Falkevall A, Klar J, Heikura T, Rissanen TT, Vähäkangas E, Korpisalo P, Enholm B, Carmeliet P, Alitalo K, Eriksson U, Ylä-Herttuala S. Vascular endothelial growth factor-B induces myocardium-specific angiogenesis and arteriogenesis via vascular endothelial growth factor receptor-1- and neuropilin receptor-1-dependent mechanisms Circulation. 119: 845-856. PMID 19188502 DOI: 10.1161/CIRCULATIONAHA.108.816454  0.32
2009 Sallinen H, Anttila M, Narvainen J, Koponen J, Hamalainen K, Kholova I, Heikura T, Toivanen P, Kosma VM, Heinonen S, Alitalo K, Yla-Herttuala S. Antiangiogenic gene therapy with soluble VEGFR-1, -2, and -3 reduces the growth of solid human ovarian carcinoma in mice Molecular Therapy. 17: 278-284. PMID 19050699 DOI: 10.1038/mt.2008.258  0.32
2009 Verstraeten VLRM, Holnthoner W, Van Steensel MAM, Veraart JCJM, Bladergroen RS, Heckman CA, Keskitalo S, Frank J, Alitalo K, Van Geel M, Steijlen PM. Functional analysis of FLT4 mutations associated with Nonne-Milroy lymphedema Journal of Investigative Dermatology. 129: 509-512. PMID 18719607 DOI: 10.1038/jid.2008.246  0.32
2009 Holopainen T, Huang H, Chen C, Kim KE, Zhang L, Zhou F, Han W, Li C, Yu J, Wu J, Koh GY, Alitalo K, He Y. Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment (Cancer Research (2009) 69, (4656-4664)) Cancer Research. 69: 5618. DOI: 10.1158/0008-5472.CAN-69-13-COR2  0.32
2008 Mitchell-Jordan SA, Holopainen T, Ren S, Wang S, Warburton S, Zhang MJ, Alitalo K, Wang Y, Vondriska TM. Loss of bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy Circulation Research. 103: 1359-1362. PMID 18988895 DOI: 10.1161/CIRCRESAHA.108.186577  0.32
2008 Lohela M, Heloterä H, Haiko P, Dumont DJ, Alitalo K. Transgenic induction of vascular endothelial growth factor-C is strongly angiogenic in mouse embryos but leads to persistent lymphatic hyperplasia in adult tissues American Journal of Pathology. 173: 1891-1901. PMID 18988807 DOI: 10.2353/ajpath.2008.080378  0.32
2008 Korpisalo P, Karvinen H, Rissanen TT, Kilpijoki J, Marjomäki V, Baluk P, McDonald DM, Cao Y, Eriksson U, Alitalo K, Ylä-Herttuala S. Vascular endothelial growth factor-A and platelet-derived growth factor-B combination gene therapy prolongs angiogenic effects via recruitment of interstitial mononuclear cells and paracrine effects rather than improved pericyte coverage of angiogenic vessels Circulation Research. 103: 1092-1099. PMID 18832750 DOI: 10.1161/CIRCRESAHA.108.182287  0.32
2008 Burton JB, Priceman SJ, Sung JL, Brakenhielm E, An DS, Pytowski B, Alitalo K, Wu L. Suppression of prostate cancer nodal and systemic metastasis by blockade of the lymphangiogenic axis. Cancer Research. 68: 7828-37. PMID 18829538 DOI: 10.1158/0008-5472.CAN-08-1488  0.32
2008 Karpanen T, Bry M, Ollila HM, Seppänen-Laakso T, Liimatta E, Leskinen H, Kivelä R, Helkamaa T, Merentie M, Jeltsch M, Paavonen K, Andersson LC, Mervaala E, Hassinen IE, Ylä-Herttuala S, ... ... Alitalo K, et al. Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy Circulation Research. 103: 1018-1026. PMID 18757827 DOI: 10.1161/CIRCRESAHA.108.178459  0.32
2008 Kirjavainen A, Sulg M, Heyd F, Alitalo K, Ylä-Herttuala S, Möröy T, Petrova TV, Pirvola U. Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia Developmental Biology. 322: 33-45. PMID 18652815 DOI: 10.1016/j.ydbio.2008.07.004  0.32
2008 Tammela T, Zarkada G, Wallgard E, Murtomäki A, Suchting S, Wirzenius M, Waltari M, Hellström M, Schomber T, Peltonen R, Freitas C, Duarte A, Isoniemi H, Laakkonen P, Christofori G, ... ... Alitalo K, et al. Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation Nature. 454: 656-660. PMID 18594512 DOI: 10.1038/nature07083  0.32
2008 Heckman CA, Holopainen T, Wirzenius M, Keskitalo S, Jeltsch M, Ylä-Herttuala S, Wedge SR, Jürgensmeier JM, Alitalo K. The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis Cancer Research. 68: 4754-4762. PMID 18559522 DOI: 10.1158/0008-5472.CAN-07-5809  0.32
2008 Petrova TV, Bono P, Holnthoner W, Chesnes J, Pytowski B, Sihto H, Laakkonen P, Heikkilä P, Joensuu H, Alitalo K. VEGFR-3 Expression Is Restricted to Blood and Lymphatic Vessels in Solid Tumors Cancer Cell. 13: 554-556. PMID 18538738 DOI: 10.1016/j.ccr.2008.04.022  0.32
2008 Melcher M, Unger B, Schmidt U, Rajantie IA, Alitalo K, Ellmeier W. Essential roles for the Tec family kinases Tec and Btk in M-CSF receptor signaling pathways that regulate macrophage survival Journal of Immunology. 180: 8048-8056. PMID 18523268  0.32
2008 Haiko P, Makinen T, Keskitalo S, Taipale J, Karkkainen MJ, Baldwin ME, Stacker SA, Achen MG, Alitalo K. Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos Molecular and Cellular Biology. 28: 4843-4850. PMID 18519586 DOI: 10.1128/MCB.02214-07  0.32
2008 Li X, Tjwa M, Van Hove I, Enholm B, Neven E, Paavonen K, Jeltsch M, Juan TD, Sievers RE, Chorianopoulos E, Wada H, Vanwildemeersch M, Noel A, Foidart JM, Springer ML, ... ... Alitalo K, et al. Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 1614-20. PMID 18511699 DOI: 10.1161/ATVBAHA.107.158725  0.32
2008 Petrova TV, Nykänen A, Norrmén C, Ivanov KI, Andersson LC, Haglund C, Puolakkainen P, Wempe F, von Melchner H, Gradwohl G, Vanharanta S, Aaltonen LA, Saharinen J, Gentile M, Clarke A, ... ... Alitalo K, et al. Transcription Factor PROX1 Induces Colon Cancer Progression by Promoting the Transition from Benign to Highly Dysplastic Phenotype Cancer Cell. 13: 407-419. PMID 18455124 DOI: 10.1016/j.ccr.2008.02.020  0.32
2008 Purhonen S, Palm J, Rossi D, Kaskenpää N, Rajantie I, Ylä-Herttuala S, Alitalo K, Weissman IL, Salven P. Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth Proceedings of the National Academy of Sciences of the United States of America. 105: 6620-6625. PMID 18443294 DOI: 10.1073/pnas.0710516105  0.32
2008 Bruyère F, Melen-Lamalle L, Blacher S, Roland G, Thiry M, Moons L, Frankenne F, Carmeliet P, Alitalo K, Libert C, Sleeman JP, Foidart JM, Noël A. Modeling lymphangiogenesis in a three-dimensional culture system Nature Methods. 5: 431-437. PMID 18425139 DOI: 10.1038/nmeth.1205  0.32
2008 Saharinen P, Eklund L, Miettinen J, Wirkkala R, Anisimov A, Winderlich M, Nottebaum A, Vestweber D, Deutsch U, Koh GY, Olsen BR, Alitalo K. Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts Nature Cell Biology. 10: 527-537. PMID 18425119 DOI: 10.1038/ncb1715  0.32
2008 Jeon BH, Jang C, Han J, Kataru RP, Piao L, Jung K, Hye JC, Schwendener RA, Kyu YJ, Kim KS, Alitalo K, Gou YK. Profound but dysfunctional lymphangiogenesis via vascular endothelial growth factor ligands from CD11b+ macrophages in advanced ovarian cancer Cancer Research. 68: 1100-1109. PMID 18281485 DOI: 10.1158/0008-5472.CAN-07-2572  0.32
2008 Benest AV, Harper SJ, Herttuala SY, Alitalo K, Bates DO. VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis Cardiovascular Research. 78: 315-323. PMID 18065770 DOI: 10.1093/cvr/cvm094  0.32
2008 Karpanen T, Alitalo K. Molecular biology and pathology of lymphangiogenesis Annual Review of Pathology: Mechanisms of Disease. 3: 367-397. PMID 18039141 DOI: 10.1146/annurev.pathmechdis.3.121806.151515  0.32
2008 Karpanen T, Alitalo K. VEGF-D: A modifier of embryonic lymphangiogenesis Blood. 112: 1547-1548. DOI: 10.1182/blood-2008-06-159343  0.32
2008 Salven P, Purhonen S, Rossi D, Ylä-Herttuala S, Alitalo K, Weissman IL. Reply to Kerbel et al.: EPCs are again claimed to be essential in yet other models despite the irreproducibility of the original experiments introducing them Proceedings of the National Academy of Sciences of the United States of America. 105: E55. DOI: 10.1073/pnas.0805971105  0.32
2008 Lohela M, Alitalo K. Molecular players in lymphangiogenesis Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy. 325-340. DOI: 10.1007/978-3-540-33177-3_18  0.32
2008 Saharinen P, Eklund L, Alitalo K. Angiopoietins and tie receptors Angiogenesis: An Integrative Approach From Science to Medicine. 113-120. DOI: 10.1007/978-0-387-71518-6_10  0.32
2007 Mäkinen T, Alitalo K. Lymphangiogenesis in development and disease Novartis Foundation Symposium. 283: 87-98. PMID 18300416  0.32
2007 Brideau G, Mäkinen MJ, Elamaa H, Tu H, Nilsson G, Alitalo K, Pihlajaniemi T, Heljasvaara R. Endostatin overexpression inhibits lymphangiogenesis and lymph node metastasis in mice Cancer Research. 67: 11528-11535. PMID 18089781 DOI: 10.1158/0008-5472.CAN-07-1458  0.32
2007 Ylä-Herttuala S, Alitalo K. On the relationship of LDL and VEGFR1: Not just a family affair Embo Reports. 8: 1127-1128. PMID 18059310 DOI: 10.1038/sj.embor.7401124  0.32
2007 Tammela T, Saaristo A, Holopainen T, Lyytikkä J, Kotronen A, Pitkonen M, Abo-Ramadan U, Ylä-Herttuala S, Petrova TV, Alitalo K. Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation Nature Medicine. 13: 1458-1466. PMID 18059280 DOI: 10.1038/nm1689  0.32
2007 Koopal S, Furuhjelm JH, Järviluoma A, Jäämaa S, Pyakurel P, Pussinen C, Wirzenius M, Biberfeld P, Alitalo K, Laiho M, Ojala PM. Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis Plos Pathogens. 3: 1348-1360. PMID 17907806 DOI: 10.1371/journal.ppat.0030140  0.32
2007 Heloterä H, Alitalo K. The VEGF Family, the Inside Story Cell. 130: 591-592. PMID 17719536 DOI: 10.1016/j.cell.2007.08.012  0.32
2007 Brakenhielm E, Burton JB, Johnson M, Chavarria N, Morizono K, Chen I, Alitalo K, Wu L. Modulating metastasis by a lymphangiogenic switch in prostate cancer. International Journal of Cancer. Journal International Du Cancer. 121: 2153-61. PMID 17583576 DOI: 10.1002/ijc.22900  0.32
2007 Gupta S, Ramjaun AR, Haiko P, Wang Y, Warne PH, Nicke B, Nye E, Stamp G, Alitalo K, Downward J. Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice. Cell. 129: 957-68. PMID 17540175 DOI: 10.1016/j.cell.2007.03.051  0.32
2007 Wirzenius M, Tammela T, Uutela M, He Y, Odorisio T, Zambruno G, Nagy JA, Dvorak HF, Ylä-Herttuala S, Shibuya M, Alitalo K. Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting Journal of Experimental Medicine. 204: 1431-1440. PMID 17535974 DOI: 10.1084/jem.20062642  0.32
2007 Stacker SA, Farnsworth RH, Karnezis T, Shayan R, Smith DP, Paavonen K, Davydova N, Caesar C, Inder R, Baldwin ME, McColl BK, Roufail S, Williams RA, Hughes RA, Alitalo K, et al. Molecular pathways for lymphangiogenesis and their role in human disease. Novartis Foundation Symposium. 281: 38-43; discussion 44. PMID 17534064  0.32
2007 Adams RH, Alitalo K. Molecular regulation of angiogenesis and lymphangiogenesis Nature Reviews Molecular Cell Biology. 8: 464-478. PMID 17522591 DOI: 10.1038/nrm2183  0.32
2007 Keskitalo S, Tammela T, Lyytikka J, Karpanen T, Jeltsch M, Markkanen J, Yla-Herttuala S, Alitalo K. Enhanced capillary formation stimulated by a chimeric vascular endothelial growth factor/vascular endothelial growth factor-C silk domain fusion protein Circulation Research. 100: 1460-1467. PMID 17478734 DOI: 10.1161/01.RES.0000269042.58594.f6  0.32
2007 Tammela T, He Y, Lyytikkä J, Jeltsch M, Markkanen J, Pajusola K, Ylä-Herttuala S, Alitalo K. Distinct architecture of lymphatic vessels induced by chimeric vascular endothelial growth factor-C/vascular endothelial growth factor heparin-binding domain fusion proteins Circulation Research. 100: 1468-1475. PMID 17478733 DOI: 10.1161/01.RES.0000269043.51272.6d  0.32
2007 Kopfstein L, Veikkola T, Djonov VG, Baeriswyl V, Schomber T, Strittmatter K, Stacker SA, Achen MG, Alitalo K, Christofori G. Distinct roles of vascular endothelial growth factor-D in lymphangiogenesis and metastasis American Journal of Pathology. 170: 1348-1361. PMID 17392173 DOI: 10.2353/ajpath.2007.060835  0.32
2007 Raisky O, Nykänen AI, Krebs R, Hollmén M, Keränen MA, Tikkanen JM, Sihvola R, Alhonen L, Salven P, Wu Y, Hicklin DJ, Alitalo K, Koskinen PK, Lemström KB. VEGFR-1 and -2 regulate inflammation, myocardial angiogenesis, and arteriosclerosis in chronically rejecting cardiac allografts. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 819-25. PMID 17290032 DOI: 10.1161/01.ATV.0000260001.55955.6c  0.32
2007 McColl BK, Paavonen K, Karnezis T, Harris NC, Davydova N, Rothacker J, Nice EC, Harder KW, Roufail S, Hibbs ML, Rogers PAW, Alitalo K, Stacker SA, Achen MG. Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2 Faseb Journal. 21: 1088-1098. PMID 17242158 DOI: 10.1096/fj.06-7060com  0.32
2007 Laakkonen P, Waltari M, Holopainen T, Takahashi T, Pytowski B, Steiner P, Hicklin D, Persaud K, Tonra JR, Witte L, Alitalo K. Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth. Cancer Research. 67: 593-9. PMID 17234768 DOI: 10.1158/0008-5472.CAN-06-3567  0.32
2007 Wick N, Saharinen P, Saharinen J, Gurnhofer E, Steiner CW, Raab I, Stokic D, Giovanoli P, Buchsbaum S, Burchard A, Thurner S, Alitalo K, Kerjaschki D. Transcriptomal comparison of human dermal lymphatic endothelial cells ex vivo and in vitro Physiological Genomics. 28: 179-192. PMID 17234577 DOI: 10.1152/physiolgenomics.00037.2006  0.32
2007 Hirakawa S, Brown LF, Kodama S, Paavonen K, Alitalo K, Detmar M. VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites. Blood. 109: 1010-7. PMID 17032920 DOI: 10.1182/blood-2006-05-021758  0.32
2006 Leppänen P, Kholová I, Mähönen AJ, Airenne K, Koota S, Mansukoski H, Närväinen J, Wirzenius M, Alhonen L, Jänne J, Alitalo K, Ylä-Herttuala S. Short and long-term effects of hVEGF-A165 in cre-activated transgenic mice Plos One. 1. PMID 17183639 DOI: 10.1371/journal.pone.0000013  0.32
2006 Tuuminen R, Nykänen A, Keränen MA, Krebs R, Alitalo K, Koskinen PK, Lemström KB. The effect of platelet-derived growth factor ligands in rat cardiac allograft vasculopathy and fibrosis. Transplantation Proceedings. 38: 3271-3. PMID 17175246 DOI: 10.1016/j.transproceed.2006.10.056  0.32
2006 He Y, Luo Y, Tang S, Rajantie I, Salven P, Heil M, Zhang R, Luo D, Li X, Chi H, Yu J, Carmeliet P, Schaper W, Sinusas AJ, Sessa WC, ... Alitalo K, et al. Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis Journal of Clinical Investigation. 116: 2344-2355. PMID 16932810 DOI: 10.1172/JCI28123  0.32
2006 Zheng Y, Murakami M, Takahashi H, Yamauchi M, Kiba A, Yamaguchi S, Yabana N, Alitalo K, Shibuya M. Chimeric VEGF-ENZ7/PlGF promotes angiogenesis via VEGFR-2 without significant enhancement of vascular permeability and inflammation Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 2019-2026. PMID 16794222 DOI: 10.1161/01.ATV.0000233336.53574.a1  0.32
2006 Schaffhauser B, Veikkola T, Strittmatter K, Antoniadis H, Alitalo K, Christofori G. Moderate antiangiogenic activity by local, transgenic expression of endostatin in Rip1Tag2 transgenic mice Journal of Leukocyte Biology. 80: 669-676. PMID 16793908 DOI: 10.1189/jlb.1105644  0.32
1985 Lin CC, Alitalo K, Schwab M, George D, Varmus HE, Bishop JM. Evolution of karyotypic abnormalities and C-MYC oncogene amplification in human colonic carcinoma cell lines. Chromosoma. 92: 11-5. PMID 4006596 DOI: 10.1007/BF00327240  0.32
1985 Schwab M, Ramsay G, Alitalo K, Varmus HE, Bishop JM, Martinsson T, Levan G, Levan A. Amplification and enhanced expression of the c-myc oncogene in mouse SEWA tumour cells. Nature. 315: 345-7. PMID 3889656 DOI: 10.1038/315345a0  0.32
1984 Alitalo K, Winqvist R, Lin CC, de la Chapelle A, Schwab M, Bishop JM. Aberrant expression of an amplified c-myb oncogene in two cell lines from a colon carcinoma. Proceedings of the National Academy of Sciences of the United States of America. 81: 4534-8. PMID 6589609  0.32
1983 Schwab M, Alitalo K, Klempnauer KH, Varmus HE, Bishop JM, Gilbert F, Brodeur G, Goldstein M, Trent J. Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour. Nature. 305: 245-8. PMID 6888561  0.32
1983 Courtneidge S, Ralston R, Alitalo K, Bishop JM. Subcellular location of an abundant substrate (p36) for tyrosine-specific protein kinases. Molecular and Cellular Biology. 3: 340-50. PMID 6341813  0.32
1983 Alitalo K, Ramsay G, Bishop JM, Pfeifer SO, Colby WW, Levinson AD. Identification of nuclear proteins encoded by viral and cellular myc oncogenes. Nature. 306: 274-7. PMID 6316149  0.32
1983 Schwab M, Alitalo K, Varmus HE, Bishop JM, George D. A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells. Nature. 303: 497-501. PMID 6304530 DOI: 10.1038/303497a0  0.32
1983 Alitalo K, Schwab M, Lin CC, Varmus HE, Bishop JM. Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma. Proceedings of the National Academy of Sciences of the United States of America. 80: 1707-11. PMID 6300869  0.32
1983 Alitalo K, Bishop JM, Smith DH, Chen EY, Colby WW, Levinson AD. Nucleotide sequence to the v-myc oncogene of avian retrovirus MC29. Proceedings of the National Academy of Sciences of the United States of America. 80: 100-4. PMID 6296857 DOI: 10.1073/pnas.80.1.100  0.32
Show low-probability matches.