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Paul A. Northcott - Publications

Affiliations: 
Developmental Neurobiology St. Jude Children's Research Hospital, San Francisco, CA, United States 
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73 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2025 Lee JJY, Tao R, You Z, Haldipur P, Erickson AW, Farooq H, Hendriske LD, Abeysundara N, Richman CM, Wang EY, Das Gupta N, Hadley J, Batts M, Mount CW, Wu X, ... ... Northcott PA, et al. ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip. Nature Genetics. PMID 39753768 DOI: 10.1038/s41588-024-02014-z  0.512
2024 Tao R, Han K, Wu SC, Friske JD, Roussel MF, Northcott PA. Arrested development: the dysfunctional life history of medulloblastoma. Genes & Development. PMID 39231614 DOI: 10.1101/gad.351936.124  0.56
2024 Schmidt C, Cohen S, Gudenas BL, Husain S, Carlson A, Westelman S, Wang L, Phillips JJ, Northcott PA, Weiss WA, Schwer B. PRDM6 promotes medulloblastoma by repressing chromatin accessibility and altering gene expression. Scientific Reports. 14: 16074. PMID 38992221 DOI: 10.1038/s41598-024-66811-6  0.332
2024 van Essen MJ, Apsley EJ, Riepsaame J, Xu R, Northcott PA, Cowley SA, Jacob J, Becker EBE. PTCH1-mutant human cerebellar organoids exhibit altered neural development and recapitulate early medulloblastoma tumorigenesis. Disease Models & Mechanisms. 17. PMID 38411252 DOI: 10.1242/dmm.050323  0.344
2023 Schmidt C, Cohen S, Gudenas BL, Husain S, Carlson A, Westelman S, Wang L, Phillips JJ, Northcott PA, Weiss WA, Schwer B. PRDM6 promotes medulloblastoma by repressing chromatin accessibility and altering gene expression. Biorxiv : the Preprint Server For Biology. PMID 37693484 DOI: 10.1101/2023.08.29.555389  0.334
2022 Smith KS, Bihannic L, Gudenas BL, Haldipur P, Tao R, Gao Q, Li Y, Aldinger KA, Iskusnykh IY, Chizhikov VV, Scoggins M, Zhang S, Edwards A, Deng M, Glass IA, ... ... Northcott PA, et al. Unified rhombic lip origins of group 3 and group 4 medulloblastoma. Nature. 609: 1012-1020. PMID 36131015 DOI: 10.1038/s41586-022-05208-9  0.553
2022 Pribnow A, Jonchere B, Liu J, Smith KS, Campagne O, Xu K, Robinson S, Patel Y, Onar-Thomas A, Wu G, Stewart CF, Northcott PA, Yu J, Robinson GW, Roussel MF. Combination of ribociclib and gemcitabine for the treatment of medulloblastoma. Molecular Cancer Therapeutics. PMID 35709750 DOI: 10.1158/1535-7163.MCT-21-0598  0.309
2021 Liu AP, Northcott PA, Robinson GW, Gajjar A. Circulating tumor DNA profiling for childhood brain tumors: Technical challenges and evidence for utility. Laboratory Investigation; a Journal of Technical Methods and Pathology. 102: 134-142. PMID 34934181 DOI: 10.1038/s41374-021-00719-x  0.306
2021 Liu AP, Northcott PA, Robinson GW, Gajjar A. Circulating tumor DNA profiling for childhood brain tumors: Technical challenges and evidence for utility. Laboratory Investigation; a Journal of Technical Methods and Pathology. 102: 134-142. PMID 34934181 DOI: 10.1038/s41374-021-00719-x  0.306
2021 Liu AP, Northcott PA, Robinson GW, Gajjar A. Circulating tumor DNA profiling for childhood brain tumors: Technical challenges and evidence for utility. Laboratory Investigation; a Journal of Technical Methods and Pathology. 102: 134-142. PMID 34934181 DOI: 10.1038/s41374-021-00719-x  0.306
2020 Garcia-Lopez J, Kumar R, Smith KS, Northcott PA. Deconstructing Sonic Hedgehog Medulloblastoma: Molecular Subtypes, Drivers, and Beyond. Trends in Genetics : Tig. PMID 33272592 DOI: 10.1016/j.tig.2020.11.001  0.379
2020 Kutscher LM, Okonechnikov K, Batora NV, Clark J, Silva PBG, Vouri M, van Rijn S, Sieber L, Statz B, Gearhart MD, Shiraishi R, Mack N, Orr BA, Korshunov A, Gudenas BL, ... ... Northcott PA, et al. Functional loss of a noncanonical BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formation. Genes & Development. PMID 32820036 DOI: 10.1101/Gad.337584.120  0.364
2020 Patmore DM, Jassim A, Nathan E, Gilbertson RJ, Tahan D, Hoffmann N, Tong Y, Smith KS, Kanneganti TD, Suzuki H, Taylor MD, Northcott P, Gilbertson RJ. DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma. Developmental Cell. PMID 32553121 DOI: 10.1016/J.Devcel.2020.05.027  0.315
2020 Waszak SM, Robinson GW, Gudenas BL, Smith KS, Forget A, Kojic M, Garcia-Lopez J, Hadley J, Hamilton KV, Indersie E, Buchhalter I, Kerssemakers J, Jäger N, Sharma T, Rausch T, ... ... Northcott PA, et al. Germline Elongator mutations in Sonic Hedgehog medulloblastoma. Nature. 580: 396-401. PMID 32296180 DOI: 10.1038/S41586-020-2164-5  0.302
2020 Hovestadt V, Ayrault O, Swartling FJ, Robinson GW, Pfister SM, Northcott PA. Medulloblastomics revisited: biological and clinical insights from thousands of patients. Nature Reviews. Cancer. 20: 42-56. PMID 31819232 DOI: 10.1038/s41568-019-0223-8  0.345
2019 Kumar R, Liu APY, Northcott PA. Medulloblastoma Genomics in the Modern Molecular Era. Brain Pathology (Zurich, Switzerland). PMID 31799776 DOI: 10.1111/bpa.12804  0.396
2019 Hovestadt V, Smith KS, Bihannic L, Filbin MG, Shaw ML, Baumgartner A, DeWitt JC, Groves A, Mayr L, Weisman HR, Richman AR, Shore ME, Goumnerova L, Rosencrance C, Carter RA, ... ... Northcott PA, et al. Resolving medulloblastoma cellular architecture by single-cell genomics. Nature. PMID 31341285 DOI: 10.1038/S41586-019-1434-6  0.37
2019 Sharma T, Schwalbe EC, Williamson D, Sill M, Hovestadt V, Mynarek M, Rutkowski S, Robinson GW, Gajjar A, Cavalli F, Ramaswamy V, Taylor MD, Lindsey JC, Hill RM, Jäger N, ... ... Northcott PA, et al. Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes. Acta Neuropathologica. PMID 31076851 DOI: 10.1007/S00401-019-02020-0  0.375
2019 Northcott PA, Robinson GW, Kratz CP, Mabbott DJ, Pomeroy SL, Clifford SC, Rutkowski S, Ellison DW, Malkin D, Taylor MD, Gajjar A, Pfister SM. Medulloblastoma. Nature Reviews. Disease Primers. 5: 11. PMID 30765705 DOI: 10.1038/s41572-019-0063-6  0.314
2018 Erkek S, Johann PD, Finetti MA, Drosos Y, Chou HC, Zapatka M, Sturm D, Jones DTW, Korshunov A, Rhyzova M, Wolf S, Mallm JP, Beck K, Witt O, Kulozik AE, ... ... Northcott PA, et al. Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation. Cancer Cell. PMID 30595504 DOI: 10.1016/J.Ccell.2018.11.014  0.321
2018 Brabetz S, Leary SES, Gröbner SN, Nakamoto MW, Şeker-Cin H, Girard EJ, Cole B, Strand AD, Bloom KL, Hovestadt V, Mack NL, Pakiam F, Schwalm B, Korshunov A, Balasubramanian GP, ... Northcott PA, et al. A biobank of patient-derived pediatric brain tumor models. Nature Medicine. PMID 30349086 DOI: 10.1038/S41591-018-0207-3  0.346
2018 Kumar R, Liu APY, Orr BA, Northcott PA, Robinson GW. Advances in the classification of pediatric brain tumors through dna methylation profiling: from research tool to frontline diagnostic. Cancer. PMID 30255939 DOI: 10.1002/Cncr.31583  0.348
2018 Carter RA, Bihannic L, Rosencrance C, Hadley JL, Tong Y, Phoenix TN, Natarajan S, Easton J, Northcott PA, Gawad C. A Single-Cell Transcriptional Atlas of the Developing Murine Cerebellum. Current Biology : Cb. PMID 30220501 DOI: 10.1016/j.cub.2018.07.062  0.303
2018 Archer TC, Ehrenberger T, Mundt F, Gold MP, Krug K, Mah CK, Mahoney EL, Daniel CJ, LeNail A, Ramamoorthy D, Mertins P, Mani DR, Zhang H, Gillette MA, Clauser K, ... ... Northcott PA, et al. Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups. Cancer Cell. 34: 396-410.e8. PMID 30205044 DOI: 10.1016/J.Ccell.2018.08.004  0.343
2018 Garancher A, Lin CY, Morabito M, Richer W, Rocques N, Larcher M, Bihannic L, Smith K, Miquel C, Leboucher S, Herath NI, Dupuy F, Varlet P, Haberler C, Walczak C, ... ... Northcott PA, et al. NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma. Cancer Cell. 33: 435-449.e6. PMID 29533784 DOI: 10.1016/J.Ccell.2018.02.006  0.302
2017 Mack SC, Pajtler KW, Chavez L, Okonechnikov K, Bertrand KC, Wang X, Erkek S, Federation A, Song A, Lee C, Wang X, McDonald L, Morrow JJ, Saiakhova A, Sin-Chan P, ... ... Northcott PA, et al. Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling. Nature. PMID 29258295 DOI: 10.1038/Nature25169  0.382
2017 Northcott PA, Buchhalter I, Morrissy AS, Hovestadt V, Weischenfeldt J, Ehrenberger T, Gröbner S, Segura-Wang M, Zichner T, Rudneva VA, Warnatz HJ, Sidiropoulos N, Phillips AH, Schumacher S, Kleinheinz K, et al. The whole-genome landscape of medulloblastoma subtypes. Nature. 547: 311-317. PMID 28726821 DOI: 10.1038/Nature22973  0.386
2017 Mack SC, Northcott PA. Genomic Analysis of Childhood Brain Tumors: Methods for Genome-Wide Discovery and Precision Medicine Become Mainstream. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 35: 2346-2354. PMID 28640705 DOI: 10.1200/JCO.2017.72.9921  0.319
2017 Vo BT, Li C, Morgan MA, Theurillat I, Finkelstein D, Wright S, Hyle J, Smith SM, Fan Y, Wang YD, Wu G, Orr BA, Northcott PA, Shilatifard A, Sherr CJ, et al. Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma. Cell Reports. 18: 2907-2917. PMID 28329683 DOI: 10.1016/J.Celrep.2017.02.073  0.337
2016 Johann PD, Erkek S, Zapatka M, Kerl K, Buchhalter I, Hovestadt V, Jones DT, Sturm D, Hermann C, Segura Wang M, Korshunov A, Rhyzova M, Gröbner S, Brabetz S, Chavez L, ... ... Northcott PA, et al. Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes. Cancer Cell. PMID 26923874 DOI: 10.1016/J.Ccell.2016.02.001  0.324
2016 Lin CY, Erkek S, Tong Y, Yin L, Federation AJ, Zapatka M, Haldipur P, Kawauchi D, Risch T, Warnatz HJ, Worst BC, Ju B, Orr BA, Zeid R, Polaski DR, ... ... Northcott PA, et al. Active medulloblastoma enhancers reveal subgroup-specific cellular origins. Nature. PMID 26814967 DOI: 10.1038/Nature16546  0.544
2016 Broniscer A, Chamdine O, Hwang S, Lin T, Pounds S, Onar-Thomas A, Shurtleff S, Allen S, Gajjar A, Northcott P, Orr BA. Gliomatosis cerebri in children shares molecular characteristics with other pediatric gliomas. Acta Neuropathologica. PMID 26744350 DOI: 10.1007/S00401-015-1532-Y  0.301
2015 Northcott PA, Pfister SM, Jones DT. Next-generation (epi)genetic drivers of childhood brain tumours and the outlook for targeted therapies. The Lancet. Oncology. 16: e293-e302. PMID 26065614 DOI: 10.1016/S1470-2045(14)71206-9  0.325
2015 Staal JA, Lau LS, Zhang H, Ingram WJ, Hallahan AR, Northcott PA, Pfister SM, Wechsler-Reya RJ, Rusert JM, Taylor MD, Cho YJ, Packer RJ, Brown KJ, Rood BR. Proteomic profiling of high risk medulloblastoma reveals functional biology. Oncotarget. 6: 14584-95. PMID 25970789 DOI: 10.18632/Oncotarget.3927  0.305
2015 Korshunov A, Ryzhova M, Hovestadt V, Bender S, Sturm D, Capper D, Meyer J, Schrimpf D, Kool M, Northcott PA, Zheludkova O, Milde T, Witt O, Kulozik AE, Reifenberger G, et al. Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers. Acta Neuropathologica. 129: 669-78. PMID 25752754 DOI: 10.1007/S00401-015-1405-4  0.392
2015 Wang X, Dubuc AM, Ramaswamy V, Mack S, Gendoo DM, Remke M, Wu X, Garzia L, Luu B, Cavalli F, Peacock J, López B, Skowron P, Zagzag D, Lyden D, ... ... Northcott PA, et al. Medulloblastoma subgroups remain stable across primary and metastatic compartments. Acta Neuropathologica. 129: 449-57. PMID 25689980 DOI: 10.1007/S00401-015-1389-0  0.372
2014 Northcott PA, Lee C, Zichner T, Stütz AM, Erkek S, Kawauchi D, Shih DJ, Hovestadt V, Zapatka M, Sturm D, Jones DT, Kool M, Remke M, Cavalli FM, Zuyderduyn S, et al. Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma. Nature. 511: 428-34. PMID 25043047 DOI: 10.1038/Nature13379  0.343
2014 Pöschl J, Stark S, Neumann P, Gröbner S, Kawauchi D, Jones DT, Northcott PA, Lichter P, Pfister SM, Kool M, Schüller U. Genomic and transcriptomic analyses match medulloblastoma mouse models to their human counterparts. Acta Neuropathologica. 128: 123-36. PMID 24871706 DOI: 10.1007/s00401-014-1297-8  0.368
2014 Hovestadt V, Jones DT, Picelli S, Wang W, Kool M, Northcott PA, Sultan M, Stachurski K, Ryzhova M, Warnatz HJ, Ralser M, Brun S, Bunt J, Jäger N, Kleinheinz K, et al. Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing. Nature. 510: 537-41. PMID 24847876 DOI: 10.1038/Nature13268  0.348
2014 Korshunov A, Sturm D, Ryzhova M, Hovestadt V, Gessi M, Jones DT, Remke M, Northcott P, Perry A, Picard D, Rosenblum M, Antonelli M, Aronica E, Schüller U, Hasselblatt M, et al. Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity. Acta Neuropathologica. 128: 279-89. PMID 24337497 DOI: 10.1007/S00401-013-1228-0  0.316
2014 Gottardo NG, Hansford JR, McGlade JP, Alvaro F, Ashley DM, Bailey S, Baker DL, Bourdeaut F, Cho YJ, Clay M, Clifford SC, Cohn RJ, Cole CH, Dallas PB, Downie P, ... ... Northcott PA, et al. Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group. Acta Neuropathologica. 127: 189-201. PMID 24264598 DOI: 10.1007/S00401-013-1213-7  0.322
2013 Jones DT, Hutter B, Jäger N, Korshunov A, Kool M, Warnatz HJ, Zichner T, Lambert SR, Ryzhova M, Quang DA, Fontebasso AM, Stütz AM, Hutter S, Zuckermann M, Sturm D, ... ... Northcott PA, et al. Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nature Genetics. 45: 927-32. PMID 23817572 DOI: 10.1038/Ng.2682  0.327
2013 Hovestadt V, Remke M, Kool M, Pietsch T, Northcott PA, Fischer R, Cavalli FM, Ramaswamy V, Zapatka M, Reifenberger G, Rutkowski S, Schick M, Bewerunge-Hudler M, Korshunov A, Lichter P, et al. Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays. Acta Neuropathologica. 125: 913-6. PMID 23670100 DOI: 10.1007/S00401-013-1126-5  0.327
2013 Jones DT, Northcott PA, Kool M, Pfister SM. The role of chromatin remodeling in medulloblastoma. Brain Pathology (Zurich, Switzerland). 23: 193-9. PMID 23432644 DOI: 10.1111/bpa.12019  0.388
2013 Dubuc AM, Remke M, Korshunov A, Northcott PA, Zhan SH, Mendez-Lago M, Kool M, Jones DT, Unterberger A, Morrissy AS, Shih D, Peacock J, Ramaswamy V, Rolider A, Wang X, et al. Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma. Acta Neuropathologica. 125: 373-84. PMID 23184418 DOI: 10.1007/S00401-012-1070-9  0.317
2013 Aref D, Moffatt CJ, Agnihotri S, Ramaswamy V, Dubuc AM, Northcott PA, Taylor MD, Perry A, Olson JM, Eberhart CG, Croul SE. Canonical TGF-β pathway activity is a predictor of SHH-driven medulloblastoma survival and delineates putative precursors in cerebellar development. Brain Pathology (Zurich, Switzerland). 23: 178-91. PMID 22966790 DOI: 10.1111/J.1750-3639.2012.00631.X  0.332
2012 Northcott PA, Dubuc AM, Pfister S, Taylor MD. Molecular subgroups of medulloblastoma Expert Review of Neurotherapeutics. 12: 871-884. PMID 22853794 DOI: 10.1586/ern.12.66  0.364
2012 Jones DT, Jäger N, Kool M, Zichner T, Hutter B, Sultan M, Cho YJ, Pugh TJ, Hovestadt V, Stütz AM, Rausch T, Warnatz HJ, Ryzhova M, Bender S, Sturm D, ... ... Northcott PA, et al. Dissecting the genomic complexity underlying medulloblastoma. Nature. 488: 100-5. PMID 22832583 DOI: 10.1038/Nature11284  0.424
2012 Pugh TJ, Weeraratne SD, Archer TC, Pomeranz Krummel DA, Auclair D, Bochicchio J, Carneiro MO, Carter SL, Cibulskis K, Erlich RL, Greulich H, Lawrence MS, Lennon NJ, McKenna A, Meldrim J, ... ... Northcott PA, et al. Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature. 488: 106-10. PMID 22820256 DOI: 10.1038/Nature11329  0.31
2012 Li M, Lockwood W, Zielenska M, Northcott P, Ra YS, Bouffet E, Yoshimoto M, Rutka JT, Yan H, Taylor MD, Eberhart C, Hawkins CE, Lam W, Squire JA, Huang A. Multiple CDK/CYCLIND genes are amplified in medulloblastoma and supratentorial primitive neuroectodermal brain tumor. Cancer Genetics. 205: 220-31. PMID 22682621 DOI: 10.1016/J.Cancergen.2012.03.002  0.319
2012 Dubuc AM, Morrissy AS, Kloosterhof NK, Northcott PA, Yu EP, Shih D, Peacock J, Grajkowska W, van Meter T, Eberhart CG, Pfister S, Marra MA, Weiss WA, Scherer SW, Rutka JT, et al. Subgroup-specific alternative splicing in medulloblastoma. Acta Neuropathologica. 123: 485-99. PMID 22358458 DOI: 10.1007/S00401-012-0959-7  0.382
2012 Kool M, Korshunov A, Remke M, Jones DT, Schlanstein M, Northcott PA, Cho YJ, Koster J, Schouten-van Meeteren A, van Vuurden D, Clifford SC, Pietsch T, von Bueren AO, Rutkowski S, McCabe M, et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathologica. 123: 473-84. PMID 22358457 DOI: 10.1007/S00401-012-0958-8  0.388
2012 Pei Y, Moore CE, Wang J, Tewari AK, Eroshkin A, Cho YJ, Witt H, Korshunov A, Read TA, Sun JL, Schmitt EM, Miller CR, Buckley AF, McLendon RE, Westbrook TF, ... Northcott PA, et al. An animal model of MYC-driven medulloblastoma. Cancer Cell. 21: 155-67. PMID 22340590 DOI: 10.1016/J.Ccr.2011.12.021  0.304
2012 Alimova I, Venkataraman S, Harris P, Marquez VE, Northcott PA, Dubuc A, Taylor MD, Foreman NK, Vibhakar R. Targeting the enhancer of zeste homologue 2 in medulloblastoma. International Journal of Cancer. Journal International Du Cancer. 131: 1800-9. PMID 22287205 DOI: 10.1002/ijc.27455  0.328
2012 Rausch T, Jones DT, Zapatka M, Stütz AM, Zichner T, Weischenfeldt J, Jäger N, Remke M, Shih D, Northcott PA, Pfaff E, Tica J, Wang Q, Massimi L, Witt H, et al. Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations. Cell. 148: 59-71. PMID 22265402 DOI: 10.1016/J.Cell.2011.12.013  0.333
2012 Korshunov A, Remke M, Kool M, Hielscher T, Northcott PA, Williamson D, Pfaff E, Witt H, Jones DTW, Ryzhova M, Cho YJ, Wittmann A, Benner A, Weiss WA, Von Deimling A, et al. Biological and clinical heterogeneity of MYCN-amplified medulloblastoma Acta Neuropathologica. 123: 515-527. PMID 22160402 DOI: 10.1007/S00401-011-0918-8  0.324
2012 Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, Eberhart CG, Parsons DW, Rutkowski S, Gajjar A, Ellison DW, Lichter P, Gilbertson RJ, Pomeroy SL, Kool M, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathologica. 123: 465-72. PMID 22134537 DOI: 10.1007/S00401-011-0922-Z  0.387
2012 Sengupta R, Dubuc A, Ward S, Yang L, Northcott P, Woerner BM, Kroll K, Luo J, Taylor MD, Wechsler-Reya RJ, Rubin JB. CXCR4 activation defines a new subgroup of Sonic hedgehog-driven medulloblastoma. Cancer Research. 72: 122-32. PMID 22052462 DOI: 10.1158/0008-5472.Can-11-1701  0.32
2011 Ramaswamy V, Northcott PA, Taylor MD. FISH and chips: The recipe for improved prognostication and outcomes for children with medulloblastoma Cancer Genetics. 204: 577-588. PMID 22200083 DOI: 10.1016/j.cancergen.2011.11.001  0.329
2011 Remke M, Hielscher T, Korshunov A, Northcott PA, Bender S, Kool M, Westermann F, Benner A, Cin H, Ryzhova M, Sturm D, Witt H, Haag D, Toedt G, Wittmann A, et al. FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 3852-61. PMID 21911727 DOI: 10.1200/JCO.2011.36.2798  0.334
2011 Witt H, Mack SC, Ryzhova M, Bender S, Sill M, Isserlin R, Benner A, Hielscher T, Milde T, Remke M, Jones DT, Northcott PA, Garzia L, Bertrand KC, Wittmann A, et al. Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma. Cancer Cell. 20: 143-57. PMID 21840481 DOI: 10.1016/J.Ccr.2011.07.007  0.397
2011 Wu X, Northcott PA, Croul S, Taylor MD. Mouse models of medulloblastoma Chinese Journal of Cancer. 30: 442-449. PMID 21718590 DOI: 10.5732/cjc.011.10040  0.311
2011 Remke M, Hielscher T, Northcott PA, Witt H, Ryzhova M, Wittmann A, Benner A, von Deimling A, Scheurlen W, Perry A, Croul S, Kulozik AE, Lichter P, Taylor MD, Pfister SM, et al. Adult medulloblastoma comprises three major molecular variants. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 2717-23. PMID 21632505 DOI: 10.1200/Jco.2011.34.9373  0.321
2011 Parsons DW, Li M, Zhang X, Jones S, Leary RJ, Lin JC, Boca SM, Carter H, Samayoa J, Bettegowda C, Gallia GL, Jallo GI, Binder ZA, Nikolsky Y, Hartigan J, ... ... Northcott PA, et al. The genetic landscape of the childhood cancer medulloblastoma. Science (New York, N.Y.). 331: 435-9. PMID 21163964 DOI: 10.1126/Science.1198056  0.325
2011 Northcott PA, Korshunov A, Witt H, Hielscher T, Eberhart CG, Mack S, Bouffet E, Clifford SC, Hawkins CE, French P, Rutka JT, Pfister S, Taylor MD. Medulloblastoma comprises four distinct molecular variants. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 1408-14. PMID 20823417 DOI: 10.1200/Jco.2009.27.4324  0.422
2010 Johnson RA, Wright KD, Poppleton H, Mohankumar KM, Finkelstein D, Pounds SB, Rand V, Leary SE, White E, Eden C, Hogg T, Northcott P, Mack S, Neale G, Wang YD, et al. Cross-species genomics matches driver mutations and cell compartments to model ependymoma. Nature. 466: 632-6. PMID 20639864 DOI: 10.1038/Nature09173  0.403
2010 Swartling FJ, Grimmer MR, Hackett CS, Northcott PA, Fan QW, Goldenberg DD, Lau J, Masic S, Nguyen K, Yakovenko S, Zhe XN, Gilmer HC, Collins R, Nagaoka M, Phillips JJ, et al. Pleiotropic role for MYCN in medulloblastoma. Genes & Development. 24: 1059-72. PMID 20478998 DOI: 10.1101/Gad.1907510  0.324
2010 Nakahara Y, Northcott PA, Li M, Kongkham PN, Smith C, Yan H, Croul S, Ra YS, Eberhart C, Huang A, Bigner D, Grajkowska W, Van Meter T, Rutka JT, Taylor MD. Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma. Neoplasia (New York, N.Y.). 12: 20-7. PMID 20072650 DOI: 10.1593/Neo.91122  0.311
2010 Northcott PA, Rutka JT, Taylor MD. Genomics of medulloblastoma: from Giemsa-banding to next-generation sequencing in 20 years. Neurosurgical Focus. 28: E6. PMID 20043721 DOI: 10.3171/2009.10.Focus09218  0.318
2010 Adamson DC, Shi Q, Wortham M, Northcott PA, Di C, Duncan CG, Li J, McLendon RE, Bigner DD, Taylor MD, Yan H. OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas. Cancer Research. 70: 181-91. PMID 20028867 DOI: 10.1158/0008-5472.Can-09-2331  0.369
2009 Fernandez-L A, Northcott PA, Dalton J, Fraga C, Ellison D, Angers S, Taylor MD, Kenney AM. YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. Genes & Development. 23: 2729-41. PMID 19952108 DOI: 10.1101/Gad.1824509  0.317
2009 Rutka JT, Kongkham P, Northcott P, Carlotti C, Guduk M, Osawa H, Moreno O, Seol HJ, Restrepo A, Weeks A, Nagai S, Smith C. The evolution and application of techniques in molecular biology to human brain tumors: a 25 year perspective. Journal of Neuro-Oncology. 92: 261-73. PMID 19357954 DOI: 10.1007/S11060-009-9829-0  0.328
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