| Year |
Citation |
Score |
| 2015 |
Kazmi F, Yerino P, Barbara JE, Parkinson A. Further Characterization of the Metabolism of Desloratadine and Its Cytochrome P450 and UDP-glucuronosyltransferase Inhibition Potential: Identification of Desloratadine as a Relatively Selective UGT2B10 Inhibitor. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 1294-302. PMID 26135009 DOI: 10.1124/dmd.115.065011 |
0.3 |
|
| 2015 |
Kazmi F, Barbara JE, Yerino P, Parkinson A. A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 523-33. PMID 25595597 DOI: 10.1124/dmd.114.062620 |
0.36 |
|
| 2012 |
Eichenbaum G, Skibbe J, Parkinson A, Johnson MD, Baumgardner D, Ogilvie B, Usuki E, Tonelli F, Holsapple J, Schmitt-Hoffmann A. Use of enzyme inhibitors to evaluate the conversion pathways of ester and amide prodrugs: a case study example with the prodrug ceftobiprole medocaril. Journal of Pharmaceutical Sciences. 101: 1242-52. PMID 22095741 DOI: 10.1002/jps.22816 |
0.311 |
|
| 2010 |
Parkinson A, Kazmi F, Buckley DB, Yerino P, Ogilvie BW, Paris BL. System-dependent outcomes during the evaluation of drug candidates as inhibitors of cytochrome P450 (CYP) and uridine diphosphate glucuronosyltransferase (UGT) enzymes: human hepatocytes versus liver microsomes versus recombinant enzymes. Drug Metabolism and Pharmacokinetics. 25: 16-27. PMID 20208386 DOI: 10.2133/Dmpk.25.16 |
0.335 |
|
| 2009 |
Nassar AE, King I, Paris BL, Haupt L, Ndikum-Moffor F, Campbell R, Usuki E, Skibbe J, Brobst D, Ogilvie BW, Parkinson A. An in vitro evaluation of the victim and perpetrator potential of the anticancer agent laromustine (VNP40101M), based on reaction phenotyping and inhibition and induction of cytochrome P450 enzymes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 1922-30. PMID 19520774 DOI: 10.1124/dmd.109.027516 |
0.366 |
|
| 2006 |
Parkinson A, Leonard N, Draper A, Ogilvie BW. On the mechanism of hepatocarcinogenesis of benzodiazepines: evidence that diazepam and oxazepam are CYP2B inducers in rats, and both CYP2B and CYP4A inducers in mice. Drug Metabolism Reviews. 38: 235-59. PMID 16684660 DOI: 10.1080/03602530600570081 |
0.324 |
|
| 2006 |
Juberg DR, Mudra DR, Hazelton GA, Parkinson A. The effect of fenbuconazole on cell proliferation and enzyme induction in the liver of female CD1 mice. Toxicology and Applied Pharmacology. 214: 178-87. PMID 16542693 DOI: 10.1016/J.Taap.2006.01.017 |
0.347 |
|
| 2006 |
Ogilvie BW, Zhang D, Li W, Rodrigues AD, Gipson AE, Holsapple J, Toren P, Parkinson A. Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: Implications for drug-drug interactions Drug Metabolism and Disposition. 34: 191-197. PMID 16299161 DOI: 10.1124/dmd.105.007633 |
0.331 |
|
| 2004 |
Parkinson A, Mudra DR, Johnson C, Dwyer A, Carroll KM. The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes. Toxicology and Applied Pharmacology. 199: 193-209. PMID 15364537 DOI: 10.1016/J.Taap.2004.01.010 |
0.353 |
|
| 2002 |
Graham RA, Downey A, Mudra D, Krueger L, Carroll K, Chengelis C, Madan A, Parkinson A. In vivo and in vitro induction of cytochrome P450 enzymes in beagle dogs. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 1206-13. PMID 12386126 DOI: 10.1124/Dmd.30.11.1206 |
0.383 |
|
| 2002 |
Luo G, Cunningham M, Kim S, Burn T, Lin J, Sinz M, Hamilton G, Rizzo C, Jolley S, Gilbert D, Downey A, Mudra D, Graham R, Carroll K, Xie J, ... ... Parkinson A, et al. CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 795-804. PMID 12065438 DOI: 10.1124/Dmd.30.7.795 |
0.302 |
|
| 2000 |
LeCluyse E, Madan A, Hamilton G, Carroll K, DeHaan R, Parkinson A. Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes. Journal of Biochemical and Molecular Toxicology. 14: 177-88. PMID 10789495 DOI: 10.1002/(Sici)1099-0461(2000)14:4<177::Aid-Jbt1>3.0.Co;2-4 |
0.307 |
|
| 1999 |
Lehman-McKeeman LD, Caudill D, Vassallo JD, Pearce RE, Madan A, Parkinson A. Effects of musk xylene and musk ketone on rat hepatic cytochrome P450 enzymes Toxicology Letters. 111: 105-115. PMID 10630706 DOI: 10.1016/S0378-4274(99)00172-1 |
0.449 |
|
| 1999 |
McKim JM, Choudhuri S, Wilga PC, Madan A, Burns-Naas LA, Gallavan RH, Mast RW, Naas DJ, Parkinson A, Meeks RG. Induction of hepatic xenobiotic metabolizing enzymes in female Fischer-344 rats following repeated inhalation exposure to decamethylcyclopentasiloxane (D5). Toxicological Sciences : An Official Journal of the Society of Toxicology. 50: 10-9. PMID 10445748 DOI: 10.1093/TOXSCI/50.1.10 |
0.377 |
|
| 1998 |
Madan A, Parkinson A, Faiman MD. Identification of the human P-450 enzymes responsible for the sulfoxidation and thiono-oxidation of diethyldithiocarbamate methyl ester: Role of P-450 enzymes in disulfiram bioactivation Alcoholism: Clinical and Experimental Research. 22: 1212-1219. PMID 9756035 |
0.348 |
|
| 1998 |
McKim JM, Wilga PC, Kolesar GB, Choudhuri S, Madan A, Dochterman LW, Breen JG, Parkinson A, Mast RW, Meeks RG. Evaluation of octamethylcyclotetrasiloxane (D4) as an inducer of rat hepatic microsomal cytochrome P450, UDP-glucuronosyltransferase, and epoxide hydrolase: A 28-day inhalation study Toxicological Sciences. 41: 29-41. PMID 9520339 DOI: 10.1006/toxs.1997.2398 |
0.367 |
|
| 1998 |
McKim JM, wilga PC, Kolesar GB, Choudhuri S, Madan A, Dochterman LW, Breen JG, Parkinson A, Mast RW, Meeks RG. Evaluation of Octamethylcyclotetrasiloxane (D4) as an Inducer of Rat Hepatic Microsomal Cytochrome P450, UDP-Glucuronosyltransferase, and Epoxide Hydrolase: A 28-Day Inhalation Study Toxicological Sciences. 41: 29-41. DOI: 10.1093/TOXSCI/41.1.29 |
0.358 |
|
| 1996 |
Bookstaff RC, Murphy VA, Skare JA, Minnema D, Sanzgiri U, Parkinson A. Effects of doxylamine succinate on thyroid hormone balance and enzyme induction in mice. Toxicology and Applied Pharmacology. 141: 584-94. PMID 8975784 DOI: 10.1006/taap.1996.0325 |
0.413 |
|
| 1996 |
Seng JE, Gandy J, Turturro A, Lipman R, Bronson RT, Parkinson a, Johnson W, Hart RW, Leakey JEA. Effects of Caloric Restriction on Expression of Testicular Cytochrome P450 Enzymes Associated with the Metabolic Activation of Carcinogens Archives of Biochemistry and Biophysics. 335: 42-52. PMID 8914833 DOI: 10.1006/Abbi.1996.0480 |
0.329 |
|
| 1996 |
Pearce RE, McIntyre CJ, Madan A, Sanzgiri U, Draper AJ, Bullock PL, Cook DC, Burton LA, Latham J, Nevins C, Parkinson A. Effects of freezing, thawing, and storing human liver microsomes on cytochrome P450 activity. Archives of Biochemistry and Biophysics. 331: 145-69. PMID 8660694 DOI: 10.1006/abbi.1996.0294 |
0.4 |
|
| 1996 |
LeCluyse EL, Bullock PL, Parkinson A. Strategies for restoration and maintenance of normal hepatic structure and function in long-term cultures of rat hepatocytes Advanced Drug Delivery Reviews. 22: 133-186. DOI: 10.1016/S0169-409X(96)00418-8 |
0.312 |
|
| 1995 |
Mani C, Pearce R, Parkinson A, Kupfer D. Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes. Carcinogenesis. 15: 2715-20. PMID 8001226 DOI: 10.1093/CARCIN/15.12.2715 |
0.397 |
|
| 1995 |
Morgan EW, Yan B, Greenway D, Petersen DR, Parkinson A. Purification and characterization of two rat liver microsomal carboxylesterases (hydrolase A and B). Archives of Biochemistry and Biophysics. 315: 495-512. PMID 7986098 DOI: 10.1006/abbi.1994.1531 |
0.584 |
|
| 1995 |
Yan B, Yang D, Parkinson A. Cloning and expression of hydrolase C, a member of the rat carboxylesterase family. Archives of Biochemistry and Biophysics. 317: 222-34. PMID 7872788 DOI: 10.1006/abbi.1995.1157 |
0.541 |
|
| 1995 |
Yan B, Yang D, Brady M, Parkinson A. Rat testicular carboxylesterase: cloning, cellular localization, and relationship to liver hydrolase A. Archives of Biochemistry and Biophysics. 316: 899-908. PMID 7864649 DOI: 10.1006/abbi.1995.1121 |
0.528 |
|
| 1995 |
Yan B, Yang D, Bullock P, Parkinson A. Rat serum carboxylesterase. Cloning, expression, regulation, and evidence of secretion from liver. The Journal of Biological Chemistry. 270: 19128-34. PMID 7642579 DOI: 10.1074/jbc.270.32.19128 |
0.55 |
|
| 1994 |
Bandyopadhyay AM, Chaudhary I, Robertson LW, Gemzik B, Parkinson A, Blouin RA. Expression of a male-specific cytochrome P450 isozyme (CYP2C11) in fa/fa Zucker rats: effect of phenobarbital treatment. Archives of Biochemistry and Biophysics. 307: 386-90. PMID 8274026 DOI: 10.1006/Abbi.1993.1604 |
0.565 |
|
| 1994 |
Morgan EW, Yan B, Greenway D, Parkinson A. Regulation of two rat liver microsomal carboxylesterase isozymes: species differences, tissue distribution, and the effects of age, sex, and xenobiotic treatment of rats. Archives of Biochemistry and Biophysics. 315: 513-26. PMID 7986099 DOI: 10.1006/abbi.1994.1532 |
0.582 |
|
| 1994 |
Yan B, Yang D, Brady M, Parkinson A. Rat kidney carboxylesterase. Cloning, sequencing, cellular localization, and relationship to rat liver hydrolase. The Journal of Biological Chemistry. 269: 29688-96. PMID 7961958 |
0.51 |
|
| 1993 |
Blouin RA, Bandyopadhyay AM, Chaudhary I, Robertson LW, Gemzik B, Parkinson A. Cytochrome P450 2B enzyme (CYP2B) induction defect following phenobarbital treatment in the fa/fa Zucker rat: molecular characterization. Archives of Biochemistry and Biophysics. 303: 313-20. PMID 8512318 DOI: 10.1006/Abbi.1993.1289 |
0.556 |
|
| 1993 |
Huang TL, Székács A, Uematsu T, Kuwano E, Parkinson A, Hammock BD. Hydrolysis of carbonates, thiocarbonates, carbamates, and carboxylic esters of alpha-naphthol, beta-naphthol, and p-nitrophenol by human, rat, and mouse liver carboxylesterases. Pharmaceutical Research. 10: 639-48. PMID 8321828 DOI: 10.1023/A:1018987111362 |
0.317 |
|
| 1993 |
Madan A, Parkinson A, Faiman MD. Role of flavin-dependent monooxygenases and cytochrome P450 enzymes in the sulfoxidation of S-methyl N,N-diethylthiolcarbamate Biochemical Pharmacology. 46: 2291-2297. PMID 8274163 DOI: 10.1016/0006-2952(93)90620-C |
0.415 |
|
| 1992 |
Parkinson A, Gemzik B. Production and purification of antibodies against rat liver P450 enzymes. Methods in Enzymology. 206: 233-45. PMID 1723782 DOI: 10.1016/0076-6879(91)06094-J |
0.366 |
|
| 1992 |
Eberhart D, Fitzgerald K, Parkinson A. Evidence for the involvement of a distinct form of cytochrome P450 3A in the oxidation of digitoxin by rat liver microsomes. Journal of Biochemical Toxicology. 7: 53-64. PMID 1588575 DOI: 10.1002/JBT.2570070110 |
0.315 |
|
| 1992 |
Pearce R, Greenway D, Parkinson A. Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: effects on coumarin, dicumarol, and testosterone oxidation. Archives of Biochemistry and Biophysics. 298: 211-25. PMID 1381906 DOI: 10.1016/0003-9861(92)90115-D |
0.373 |
|
| 1991 |
Bullock P, Gemzik B, Johnson D, Thomas P, Parkinson A. Evidence from dwarf rats that growth hormone may not regulate the sexual differentiation of liver cytochrome P450 enzymes and steroid 5 alpha-reductase. Proceedings of the National Academy of Sciences of the United States of America. 88: 5227-31. PMID 2052602 DOI: 10.1073/pnas.88.12.5227 |
0.348 |
|
| 1991 |
Ramsdell HS, Parkinson A, Eddy AC, Eaton DL. Bioactivation of aflatoxin B1 by human liver microsomes: role of cytochrome P450 IIIA enzymes. Toxicology and Applied Pharmacology. 108: 436-47. PMID 1902334 DOI: 10.1016/0041-008X(91)90090-2 |
0.4 |
|
| 1991 |
Seng JE, Leakey JE, Arlotto MP, Parkinson A, Gandy J. Cellular localization of cytochrome P450IIA1 in testes of mature Sprague-Dawley rats. Biology of Reproduction. 45: 876-882. PMID 1805990 DOI: 10.1095/Biolreprod45.6.876 |
0.307 |
|
| 1991 |
Eberhart DC, Parkinson A. Cytochrome P450 IIIA1 (P450p) requires cytochrome b5 and phospholipid with unsaturated fatty acids. Archives of Biochemistry and Biophysics. 291: 231-40. PMID 1659320 DOI: 10.1016/0003-9861(91)90128-6 |
0.354 |
|
| 1990 |
Gemzik B, Halvorson MR, Parkinson A. Pronounced and differential effects of ionic strength and pH on testosterone oxidation by membrane-bound and purified forms of rat liver microsomal cytochrome P-450. Journal of Steroid Biochemistry. 35: 429-40. PMID 2325409 DOI: 10.1016/0022-4731(90)90251-M |
0.338 |
|
| 1990 |
Halvorson M, Greenway D, Eberhart D, Fitzgerald K, Parkinson A. Reconstitution of testosterone oxidation by purified rat cytochrome P450p (IIIA1). Archives of Biochemistry and Biophysics. 277: 166-80. PMID 2106291 DOI: 10.1016/0003-9861(90)90566-H |
0.387 |
|
| 1989 |
Sonderfan AJ, Arlotto MP, Parkinson A. Identification of the cytochrome P-450 isozymes responsible for testosterone oxidation in rat lung, kidney, and testis: evidence that cytochrome P-450a (P450IIA1) is the physiologically important testosterone 7 alpha-hydroxylase in rat testis. Endocrinology. 125: 857-66. PMID 2752981 DOI: 10.1210/ENDO-125-2-857 |
0.326 |
|
| 1989 |
Arlotto MP, Greenway DJ, Parkinson A. Purification of two isozymes of rat liver microsomal cytochrome P450 with testosterone 7 alpha-hydroxylase activity. Archives of Biochemistry and Biophysics. 270: 441-57. PMID 2650624 DOI: 10.1016/0003-9861(89)90526-2 |
0.379 |
|
| 1989 |
Dutton DR, Parkinson A. Reduction of 7-alkoxyresorufins by NADPH-cytochrome P450 reductase and its differential effects on their O-dealkylation by rat liver microsomal cytochrome P450. Archives of Biochemistry and Biophysics. 268: 617-29. PMID 2536534 DOI: 10.1016/0003-9861(89)90329-9 |
0.307 |
|
| 1989 |
Arlotto MP, Parkinson A. Identification of cytochrome P450a (P450IIA1) as the principal testosterone 7 alpha-hydroxylase in rat liver microsomes and its regulation by thyroid hormones. Archives of Biochemistry and Biophysics. 270: 458-71. PMID 2495766 DOI: 10.1016/0003-9861(89)90527-4 |
0.343 |
|
| 1988 |
Dutton DR, McMillen SK, Parkinson A. Purification of rat liver microsomal cytochrome P-450b without the use of nonionic detergent. Journal of Biochemical Toxicology. 3: 131-45. PMID 3148724 DOI: 10.1002/JBT.2570030207 |
0.389 |
|
| 1988 |
Parkinson A, Thomas PE, Ryan DE, Levin W, Fujita T, Safe S. Induction of rat liver microsomal cytochrome P-450 isozymes and epoxide hydrolase by a series of 4'-substituted-2,3,4,5-tetrachlorobiphenyls. Toxicology. 53: 289-300. PMID 3145631 DOI: 10.1016/0300-483X(88)90221-1 |
0.558 |
|
| 1988 |
Halvorson MR, Safe SH, Parkinson A, Phillips TD. Aflatoxin B1 hydroxylation by the pregnenolone-16 alpha-carbonitrile-inducible form of rat liver microsomal cytochrome P-450. Carcinogenesis. 9: 2103-8. PMID 3141079 DOI: 10.1093/carcin/9.11.2103 |
0.563 |
|
| 1988 |
Astroff B, Zacharewski T, Safe S, Arlotto MP, Parkinson A, Thomas P, Levin W. 6-Methyl-1,3,8-trichlorodibenzofuran as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: inhibition of the induction of rat cytochrome P-450 isozymes and related monooxygenase activities. Molecular Pharmacology. 33: 231-6. PMID 2828916 |
0.554 |
|
| 1987 |
Sonderfan AJ, Arlotto MP, Dutton DR, McMillen SK, Parkinson A. Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P-450. Archives of Biochemistry and Biophysics. 255: 27-41. PMID 3592665 DOI: 10.1016/0003-9861(87)90291-8 |
0.336 |
|
| 1987 |
Arlotto MP, Sonderfan AJ, Klaassen CD, Parkinson A. Studies on the pregnenolone-16 alpha-carbonitrile-inducible form of rat liver microsomal cytochrome P-450 and UDP-glucuronosyltransferase. Biochemical Pharmacology. 36: 3859-66. PMID 3120728 DOI: 10.1016/0006-2952(87)90450-3 |
0.436 |
|
| 1987 |
Dutton DR, McMillen SK, Sonderfan AJ, Thomas PE, Parkinson A. Studies on the rate-determining factor in testosterone hydroxylation by rat liver microsomal cytochrome P-450: evidence against cytochrome P-450 isozyme:isozyme interactions. Archives of Biochemistry and Biophysics. 255: 316-28. PMID 3109324 DOI: 10.1016/0003-9861(87)90399-7 |
0.384 |
|
| 1987 |
Arlotto MP, Sonderfan AJ, McKinney MM, Parkinson A. Digitoxin metabolism by liver microsomal cytochrome P-450 and UDP-glucuronosyltransferase and its role in the protection of rats from digitoxin toxicity by pregnenolone-16 alpha-carbonitrile. Archives of Biochemistry and Biophysics. 251: 188-97. PMID 3098175 DOI: 10.1016/0003-9861(86)90065-2 |
0.433 |
|
| 1986 |
Li SM, Denomme MA, Leece B, Safe S, Dutton D, Parkinson A, Thomas PE, Ryan D, Bandiera S, Reik LM. Hexachlorobenzene and substituted pentachlorobenzenes (X-C6Cl5) as inducers of hepatic cytochrome P-450-dependent mono-oxygenases. Iarc Scientific Publications. 527-34. PMID 3596752 |
0.394 |
|
| 1986 |
Parkinson A, Thomas PE, Ryan DE, Gorsky LD, Shively JE, Sayer JM, Jerina DM, Levin W. Mechanism of inactivation of rat liver microsomal cytochrome P-450c by 2-bromo-4'-nitroacetophenone. Journal of Biological Chemistry. 261: 11487-11495. DOI: 10.1016/s0021-9258(18)67270-9 |
0.381 |
|
| 1986 |
Parkinson A, Ryan DE, Thomas PE, Jerina DM, Sayer JM, van Bladeren PJ, Haniu M, Shively JE, Levin W. Chemical modification and inactivation of rat liver microsomal cytochrome P-450c by 2-bromo-4'-nitroacetophenone. Journal of Biological Chemistry. 261: 11478-11486. DOI: 10.1016/s0021-9258(18)67269-2 |
0.389 |
|
| 1985 |
Gorski JR, Arlotto MP, Klaassen CD, Parkinson A. Age- and sex-dependent induction of liver microsomal benzo[a]pyrene hydroxylase activity in rats treated with pregnenolone-16 alpha-carbonitrile (PCN). Carcinogenesis. 6: 617-24. PMID 3986963 DOI: 10.1093/Carcin/6.4.617 |
0.367 |
|
| 1985 |
Rozman K, Hazelton GA, Klaassen CD, Arlotto MP, Parkinson A. Effect of thyroid hormones on liver microsomal enzyme induction in rats exposed to 2,3,7,8,-tetrachlorodibenzo-p-dioxin. Toxicology. 37: 51-63. PMID 3933144 DOI: 10.1016/0300-483X(85)90112-X |
0.42 |
|
| 1985 |
Safe S, Bandiera S, Sawyer T, Robertson L, Safe L, Parkinson A, Thomas PE, Ryan DE, Reik LM, Levin W. PCBs: structure-function relationships and mechanism of action. Environmental Health Perspectives. 60: 47-56. PMID 2992927 DOI: 10.1289/ehp.856047 |
0.428 |
|
| 1985 |
Safe S, Bandiera S, Sawyer T, Robertson L, Safe L, Parkinson A, Thomas PE, Ryan DE, Reik LM, Levin W, Denomme MA, Fujita T. PCBs: Structure-Function Relationships and Mechanism of Action Environmental Health Perspectives. 60: 47. DOI: 10.2307/3429944 |
0.588 |
|
| 1984 |
Ryan DE, Thomas PE, Parkinson A, Reik LM, Wood AW, Levin W. Characterization and regulation of rat hepatic microsomal cytochrome P-450 isozymes. Annals of the New York Academy of Sciences. 435: 73-85. PMID 6598008 DOI: 10.1111/j.1749-6632.1984.tb13741.x |
0.404 |
|
| 1984 |
Robertson LW, Parkinson A, Bandiera S, Lambert I, Merrill J, Safe SH. PCBs and PBBs: biologic and toxic effects on C57BL/6J and DBA/2J inbred mice. Toxicology. 31: 191-206. PMID 6330936 DOI: 10.1016/0300-483x(84)90101-x |
0.557 |
|
| 1984 |
Robertson LW, Thompson K, Parkinson A. Synthesis, characterization and biologic effects of polybrominated naphthalenes. Archives of Toxicology. 55: 127-31. PMID 6089700 DOI: 10.1007/BF00346051 |
0.637 |
|
| 1984 |
Robertson LW, Safe SH, Parkinson A, Pellizzari E, Pochini C, Mullin MD. Synthesis and identification of highly toxic polybrominated biphenyls in the fire retardant Firemaster BP-6 Journal of Agricultural and Food Chemistry. 32: 1107-1111. DOI: 10.1021/Jf00125A045 |
0.525 |
|
| 1983 |
Parkinson A, Robertson LW, Safe S. Binding of metyrapone to dithionite-reduced cytochrome P-450 from rats treated with xenobiotics. Biochemical Pharmacology. 31: 3489-94. PMID 7150369 DOI: 10.1016/0006-2952(82)90631-1 |
0.622 |
|
| 1983 |
Campbell MA, Bandiera S, Robertson L, Parkinson A, Safe S. Hepta-, hexa-, tetra- and dichloronaphthalene congeners as inducers of hepatic microsomal drug-metabolizing enzymes. Toxicology. 26: 193-205. PMID 6857695 DOI: 10.1016/0300-483X(83)90081-1 |
0.702 |
|
| 1983 |
Parkinson A, Thomas PE, Ryan DE, Levin W. The in vivo turnover of rat liver microsomal epoxide hydrolase and both the apoprotein and heme moieties of specific cytochrome P-450 isozymes. Archives of Biochemistry and Biophysics. 225: 216-36. PMID 6614919 DOI: 10.1016/0003-9861(83)90025-5 |
0.319 |
|
| 1983 |
Parkinson A, Thomas PE, Ryan DE, Reik LM, Safe SH, Robertson LW, Levin W. Differential time course of induction of rat liver microsomal cytochrome P-450 isozymes and epoxide hydrolase by Aroclor 1254. Archives of Biochemistry and Biophysics. 225: 203-15. PMID 6412631 DOI: 10.1016/0003-9861(83)90024-3 |
0.642 |
|
| 1983 |
Parkinson A, Robertson LW, Safe SH. Induction of rat hepatic microsomal cytochrome P-450 by 2,3',4,4',5,5'-hexachlorobiphenyl. Biochemical Pharmacology. 32: 2269-79. PMID 6409119 DOI: 10.1016/0006-2952(83)90237-X |
0.674 |
|
| 1983 |
Parkinson A, Safe SH, Robertson LW, Thomas PE, Ryan DE, Reik LM, Levin W. Immunochemical quantitation of cytochrome P-450 isozymes and epoxide hydrolase in liver microsomes from polychlorinated or polybrominated biphenyl-treated rats. A study of structure-activity relationships. The Journal of Biological Chemistry. 258: 5967-76. PMID 6304102 |
0.417 |
|
| 1983 |
Robertson LW, Parkinson A, Campbell MA, Safe S. Polybrominated biphenyls as aryl hydrocarbon hydroxylase inducers: structure-activity correlations. Chemico-Biological Interactions. 42: 53-66. PMID 6295646 DOI: 10.1016/0009-2797(82)90141-7 |
0.665 |
|
| 1982 |
Parkinson A, Robertson LW, Safe S. Further characterization and applications of the 4-chlorobiphenyl hydroxylase assay. Advances in Experimental Medicine and Biology. 753-9. PMID 7344491 DOI: 10.1007/978-1-4757-0674-1_57 |
0.596 |
|
| 1982 |
Parkinson A, Safe S. The cytochrome P-450-mediated metabolism of biphenyl and the 4-halobiphenyls. Advances in Experimental Medicine and Biology. 745-52. PMID 7344490 DOI: 10.1007/978-1-4757-0674-1_56 |
0.447 |
|
| 1982 |
Parkinson A, Safe S. Cytochrome P-450-mediated metabolism of biphenyl and the 4-halobiphenyls. Biochemical Pharmacology. 31: 1849-56. PMID 7104016 DOI: 10.1016/0006-2952(82)90487-7 |
0.501 |
|
| 1982 |
Parkinson A, Robertson L, Uhlig L, Campbell MA, Safe S. 2,3,4,4'-Pentachlorobiphenyl: differential effects on C57BL/6J and DBA/2J inbred mice. Biochemical Pharmacology. 31: 2830-3. PMID 6814446 DOI: 10.1016/0006-2952(82)90143-5 |
0.488 |
|
| 1982 |
Safe S, Robertson LW, Safe L, Parkinson A, Bandiera S, Sawyer T, Campbell MA. Halogenated biphenyls: molecular toxicology. Canadian Journal of Physiology and Pharmacology. 60: 1057-64. PMID 6812934 DOI: 10.1139/Y82-151 |
0.663 |
|
| 1981 |
Parkinson A, Copp L, Safe S. The utility of the microsomal 4-chlorobiphenyl hydroxylase enzyme assay in distinguishing between phenobarbitone- and 3-methylcholanthrene-induced microsomal monooxygenases. Analytical Biochemistry. 105: 65-73. PMID 7446991 DOI: 10.1016/0003-2697(80)90424-8 |
0.534 |
|
| 1981 |
Campbell MA, Bandiera S, Robertson L, Parkinson A, Safe S. Octachloronaphthalene induction of hepatic microsomal aryl hydrocarbon hydroxylase activity in the immature male rat. Toxicology. 22: 123-32. PMID 7324072 DOI: 10.1016/0300-483X(81)90112-8 |
0.69 |
|
| 1981 |
Parkinson A, Robertson LW, Safe S. Hepatic microsomal enzyme induction by 2,2', 3,3', 4,4'- and 2,2', 3', 4,4', 5-hexachlorobiphenyl. Life Sciences. 27: 2333-7. PMID 6782406 DOI: 10.1016/0024-3205(80)90502-0 |
0.661 |
|
| 1981 |
Parkinson A, Robertson LW, Safe L, Safe S. Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: effects of di-ortho substitution. Chemico-Biological Interactions. 35: 1-12. PMID 6781768 DOI: 10.1016/0009-2797(81)90059-4 |
0.677 |
|
| 1981 |
Robertson LW, Parkinson A, Chittim B, Bandiera S, Sawyer TW, Safe S. Aryl hydrocarbon hydroxylase (AHH) induction by polybrominated biphenyls (PBBs): enchancement by photolysis. Toxicology. 22: 103-14. PMID 6275573 DOI: 10.1016/0300-483X(81)90110-4 |
0.62 |
|
| 1981 |
Robertson L, Parkinson A, Safe S. Induction of drug-metabolizing enzymes by fractionated commercial polybrominated biphenyls (PBBs). Toxicology and Applied Pharmacology. 57: 254-62. PMID 6261418 DOI: 10.1016/0041-008X(81)90287-8 |
0.631 |
|
| 1981 |
Robertson LW, Parkinson A, Bandiera S, Safe S. Potent induction of rat liver microsomal, drug-metabolizing enzymes by 2,3,3',4,4',5-hexabromobiphenyl, a component of fireMaster. Chemico-Biological Interactions. 35: 13-24. PMID 6258818 DOI: 10.1016/0009-2797(81)90060-0 |
0.683 |
|
| 1981 |
Safe S, Robertson L, Safe L, Parkinson A, Campbell M, Sawyer T, Bandiera S. POLYCHLORINATED BIPHENYLS (PCBs) AS INDUCERS OF THE HEPATIC MICROSOMAL DRUG-METABOLIZING ENZYMES - EFFECTS OF STRUCTURE ON ACTIVITY Drug Metabolism and Drug Interactions. 3. DOI: 10.1515/Dmdi.1981.3.4.255 |
0.631 |
|
| 1981 |
Parkinson A, Safe S. Aryl hydrocarbon hydroxylase induction and its relationship to the toxicity of halogenated aryl hydrocarbons Toxicological & Environmental Chemistry. 4: 1-46. DOI: 10.1080/02772248109356957 |
0.349 |
|
| 1980 |
Parkinson A, Robertson LW, Safe S. Reconstituted human breast milk PCBs as potent inducers of aryl hydrocarbon hydroxylase. Biochemical and Biophysical Research Communications. 96: 882-9. PMID 6775632 DOI: 10.1016/0006-291X(80)91438-2 |
0.54 |
|
| 1980 |
Parkinson A, Robertson L, Safe L, Safe S. Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: structure-activity rules. Chemico-Biological Interactions. 30: 271-85. PMID 6769597 DOI: 10.1016/0009-2797(80)90050-2 |
0.707 |
|
| 1980 |
Parkinson A, Cockerline R, Safe S. Induction of both 3-methylcholanthrene- and phenobarbitone-type microsomal enzyme activity by a single polychlorinated biphenyl isomer. Biochemical Pharmacology. 29: 259-62. PMID 6767483 DOI: 10.1016/0006-2952(80)90339-1 |
0.459 |
|
| 1980 |
Parkinson A, Cockerline R, Safe S. Polychlorinated biphenyl isomers and congeners as inducers of both 3-methylcholanthrene- and phenobarbitone-type microsomal enzyme activity. Chemico-Biological Interactions. 29: 277-89. PMID 6766814 DOI: 10.1016/0009-2797(80)90147-7 |
0.542 |
|
| 1980 |
Robertson LW, Parkinson A, Safe S. Induction of both cytochromes P-450 and P-448 by 2,3',4,4',5-pentabromobiphenyl, a component of fireMaster. Biochemical and Biophysical Research Communications. 92: 175-82. PMID 6243934 DOI: 10.1016/0006-291X(80)91536-3 |
0.7 |
|
| 1980 |
Parkinson A, Copp L, Safe S. 4-Chlorobiphenyl Hydroxylase: A Monooxygenase Preferentially Induced By 3-Methylcholanthrene Microsomes, Drug Oxidations and Chemical Carcinogenesis. 977-980. DOI: 10.1016/B978-0-12-187702-6.50077-3 |
0.502 |
|
| 1980 |
Parkinson A, Cockerline R, Robertson L, Safe S. Induction Of Cytochrome P-448 And P-450 By Pcb Isomers And Congeners Microsomes, Drug Oxidations and Chemical Carcinogenesis. 579-582. DOI: 10.1016/B978-0-12-187701-9.50113-3 |
0.52 |
|
| 1979 |
Parkinson A, Safe S. The detection of enzyme induction by rat liver microsomes prepared by isoelectric precipitation. The Journal of Pharmacy and Pharmacology. 31: 444-7. PMID 38312 DOI: 10.1111/J.2042-7158.1979.Tb13550.X |
0.579 |
|
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