Dung-Fang Lee, Ph.D. - Publications

2002-2008 Molecular and Cellular Oncology The University of Texas Health Science Center at Houston, USA 
Cancer. Stem Cells

83 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Li HB, Huang G, Tu J, Lv DM, Jin QL, Chen JK, Zou YT, Lee DF, Shen JN, Xie XB. METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma. Ebiomedicine. 82: 104142. PMID 35810559 DOI: 10.1016/j.ebiom.2022.104142  0.593
2022 Chen YH, Huang PS, Wen MH, Pan M, Lee DF, Chen TY. Generation of a homozygous knock-in human embryonic stem cell line expressing mEos4b-tagged CTR1. Stem Cell Research. 63: 102845. PMID 35728441 DOI: 10.1016/j.scr.2022.102845  0.633
2022 Tu J, Huo Z, Yu Y, Zhu D, Xu A, Huang MF, Hu R, Wang R, Gingold JA, Chen YH, Tsai KL, Forcioli-Conti NR, Huang SXL, Webb TR, Su J, ... Lee DF, et al. Hereditary retinoblastoma iPSC model reveals aberrant spliceosome function driving bone malignancies. Proceedings of the National Academy of Sciences of the United States of America. 119: e2117857119. PMID 35412907 DOI: 10.1073/pnas.2117857119  0.734
2022 Malla S, Prasad Bhattarai D, Groza P, Melguizo-Sanchis D, Atanasoai I, Martinez-Gamero C, Román ÁC, Zhu D, Lee DF, Kutter C, Aguilo F. ZFP207 sustains pluripotency by coordinating OCT4 stability, alternative splicing and RNA export. Embo Reports. e53191. PMID 35037361 DOI: 10.15252/embr.202153191  0.64
2021 Jewell BE, Xu A, Zhu D, Huang MF, Lu L, Liu M, Underwood EL, Park JH, Fan H, Gingold JA, Zhou R, Tu J, Huo Z, Liu Y, Jin W, ... ... Lee DF, et al. Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome. Plos Genetics. 17: e1009971. PMID 34965247 DOI: 10.1371/journal.pgen.1009971  0.623
2021 Huang MF, Pang LK, Chen YH, Zhao R, Lee DF. Cardiotoxicity of Antineoplastic Therapies and Applications of Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Cells. 10. PMID 34831045 DOI: 10.3390/cells10112823  0.623
2021 Chiang YT, Chien YC, Lin YH, Wu HH, Lee DF, Yu YL. The Function of the Mutant p53-R175H in Cancer. Cancers. 13. PMID 34439241 DOI: 10.3390/cancers13164088  0.628
2021 Huang PS, Wen MH, Xie X, Xu A, Lee DF, Chen TY. Corrigendum to "Generation of a homozygous knock-in human embryonic stem cell line expressing SNAP-tagged SOD1" [Stem Cell Res. 54 (2021) 102415]. Stem Cell Research. 55: 102483. PMID 34330033 DOI: 10.1016/j.scr.2021.102483  0.633
2021 Huang PS, Wen MH, Xie X, Xu A, Lee DF, Chen TY. Generation of a homozygous knock-in human embryonic stem cell line expressing SNAP-tagged SOD1. Stem Cell Research. 54: 102415. PMID 34118566 DOI: 10.1016/j.scr.2021.102415  0.625
2021 Xiong F, Wang R, Lee JH, Li S, Chen SF, Liao Z, Hasani LA, Nguyen PT, Zhu X, Krakowiak J, Lee DF, Han L, Tsai KL, Liu Y, Li W. RNA mA modification orchestrates a LINE-1-host interaction that facilitates retrotransposition and contributes to long gene vulnerability. Cell Research. PMID 34108665 DOI: 10.1038/s41422-021-00515-8  0.59
2021 Sevilla A, Papatsenko D, Mazloom AR, Xu H, Vasileva A, Unwin RD, LeRoy G, Chen EY, Garrett-Bakelman FE, Lee DF, Trinite B, Webb RL, Wang Z, Su J, Gingold J, et al. An Esrrb and Nanog Cell Fate Regulatory Module Controlled by Feed Forward Loop Interactions. Frontiers in Cell and Developmental Biology. 9: 630067. PMID 33816475 DOI: 10.3389/fcell.2021.630067  0.741
2021 Papapetrou EP, Lee DF. Reprogramming and cancer. Stem Cell Research. 52: 102249. PMID 33610014 DOI: 10.1016/j.scr.2021.102249  0.599
2020 Xu A, Huang MF, Zhu D, Gingold JA, Bazer DA, Chang B, Wang D, Lai CC, Lemischka IR, Zhao R, Lee DF. LncRNA H19 Suppresses Osteosarcomagenesis by Regulating snoRNAs and DNA Repair Protein Complexes. Frontiers in Genetics. 11: 611823. PMID 33519915 DOI: 10.3389/fgene.2020.611823  0.73
2020 Pang LK, Pena M, Zhao R, Lee DF. Modeling of osteosarcoma with induced pluripotent stem cells. Stem Cell Research. 49: 102006. PMID 33022533 DOI: 10.1016/j.scr.2020.102006  0.643
2020 Li H, Tu J, Zhao Z, Chen L, Qu Y, Li H, Yao H, Wang X, Lee DF, Shen J, Wen L, Huang G, Xie X. Molecular signatures of BRCAness analysis identifies PARP inhibitor Niraparib as a novel targeted therapeutic strategy for soft tissue Sarcomas. Theranostics. 10: 9477-9494. PMID 32863940 DOI: 10.7150/thno.45763  0.617
2020 Li A, Mallik S, Luo H, Jia P, Lee DF, Zhao Z. H19, a Long Non-coding RNA, Mediates Transcription Factors and Target Genes through Interference of MicroRNAs in Pan-Cancer. Molecular Therapy. Nucleic Acids. 21: 180-191. PMID 32585626 DOI: 10.1016/j.omtn.2020.05.028  0.619
2020 Huo Z, Tu J, Lee DF, Zhao R. Engineering Mutation Clones in Mammalian Cells with CRISPR/Cas9. Methods in Molecular Biology (Clifton, N.J.). 2108: 355-369. PMID 31939194 DOI: 10.1007/978-1-0716-0247-8_29  0.618
2019 Wen MH, Xie X, Tu J, Lee DF, Chen TY. Generation of a genetically modified human embryonic stem cells expressing fluorescence tagged ATOX1. Stem Cell Research. 41: 101631. PMID 31704540 DOI: 10.1016/J.Scr.2019.101631  0.641
2019 Su J, Zhu D, Huo Z, Gingold JA, Ang YS, Tu J, Zhou R, Lin Y, Luo H, Yang H, Zhao R, Schaniel C, Moore KA, Lemischka IR, Lee DF. Genomic Integrity Safeguards Self-Renewal in Embryonic Stem Cells. Cell Reports. 28: 1400-1409.e4. PMID 31390555 DOI: 10.1016/J.Celrep.2019.07.011  0.801
2018 Ivanova N, Pereira CF, Lee DF. Ihor R. Lemischka (1953-2017). Cell Stem Cell. 22: 16-17. PMID 33253628 DOI: 10.1016/j.stem.2017.12.015  0.508
2018 Kim H, Yoo S, Zhou R, Xu A, Bernitz JM, Yuan Y, Gomes AM, Daniel MG, Su J, Demicco EG, Zhu J, Moore KA, Lee DF, Lemischka IR, Schaniel C. Oncogenic role of SFRP2 in p53-mutant osteosarcoma development via autocrine and paracrine mechanism. Proceedings of the National Academy of Sciences of the United States of America. PMID 30385632 DOI: 10.1073/Pnas.1814044115  0.745
2018 Jewell BE, Liu M, Lu L, Zhou R, Tu J, Zhu D, Huo Z, Xu A, Wang D, Mata H, Jin W, Xia W, Rao PH, Zhao R, Hung MC, ... ... Lee DF, et al. Generation of an induced pluripotent stem cell line from an individual with a heterozygous RECQL4 mutation. Stem Cell Research. 33: 36-40. PMID 30312871 DOI: 10.1016/J.Scr.2018.10.003  0.671
2018 Zhu D, Kong CSL, Gingold JA, Zhao R, Lee DF. Induced Pluripotent Stem Cells and Induced Pluripotent Cancer Cells in Cancer Disease Modeling. Advances in Experimental Medicine and Biology. PMID 30069853 DOI: 10.1007/5584_2018_257  0.656
2018 Liu M, Tu J, Gingold JA, Kong CSL, Lee DF. Cancer in a dish: progress using stem cells as a platform for cancer research. American Journal of Cancer Research. 8: 944-954. PMID 30034933  0.656
2018 Zhou R, Xu A, Tu J, Liu M, Gingold JA, Zhao R, Lee DF. Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells. Journal of Visualized Experiments : Jove. PMID 29985349 DOI: 10.3791/57664  0.647
2018 Xu A, Zhou R, Tu J, Huo Z, Zhu D, Wang D, Gingold JA, Mata H, Rao PH, Liu M, Mohamed AMT, Kong CSL, Jewell BE, Xia W, Zhao R, ... ... Lee DF, et al. Establishment of a human embryonic stem cell line with homozygous TP53 R248W mutant by TALEN mediated gene editing. Stem Cell Research. 29: 215-219. PMID 29730572 DOI: 10.1016/j.scr.2018.04.013  0.703
2018 Gingold JA, Zhu D, Lee DF, Kaseb A, Chen J. Genomic Profiling and Metabolic Homeostasis in Primary Liver Cancers. Trends in Molecular Medicine. PMID 29530485 DOI: 10.1016/j.molmed.2018.02.006  0.594
2018 Zhou R, Xu A, Wang D, Zhu D, Mata H, Huo Z, Tu J, Liu M, Mohamed AMT, Jewell BE, Gingold J, Xia W, Rao PH, Hung MC, Zhao R, ... Lee DF, et al. A homozygous p53 R282W mutant human embryonic stem cell line generated using TALEN-mediated precise gene editing. Stem Cell Research. 27: 131-135. PMID 29414603 DOI: 10.1016/j.scr.2018.01.035  0.707
2018 Tu J, Huo Z, Liu M, Wang D, Xu A, Zhou R, Zhu D, Gingold J, Shen J, Zhao R, Lee DF. Generation of human embryonic stem cell line with heterozygous RB1 deletion by CRIPSR/Cas9 nickase. Stem Cell Research. 28: 29-32. PMID 29414415 DOI: 10.1016/J.Scr.2018.01.021  0.651
2017 Zhou R, Xu A, Gingold J, Strong LC, Zhao R, Lee DF. Li-Fraumeni Syndrome Disease Model: A Platform to Develop Precision Cancer Therapy Targeting Oncogenic p53. Trends in Pharmacological Sciences. PMID 28818333 DOI: 10.1016/j.tips.2017.07.004  0.635
2017 Lin YH, Jewell BE, Gingold J, Lu L, Zhao R, Wang LL, Lee DF. Osteosarcoma: Molecular Pathogenesis and iPSC Modeling. Trends in Molecular Medicine. PMID 28735817 DOI: 10.1016/J.Molmed.2017.06.004  0.599
2017 Freire AG, Waghray A, Soares-da-Silva F, Resende TP, Lee DF, Pereira CF, Nascimento DS, Lemischka IR, Pinto-do-Ó P. Transient HES5 Activity Instructs Mesodermal Cells toward a Cardiac Fate. Stem Cell Reports. PMID 28648899 DOI: 10.1016/J.Stemcr.2017.05.025  0.718
2017 Tu J, Huo Z, Gingold J, Zhao R, Shen J, Lee DF. The Histogenesis of Ewing Sarcoma. Cancer Reports and Reviews. 1. PMID 28626837  0.528
2016 Gingold J, Zhou R, Lemischka IR, Lee DF. Modeling Cancer with Pluripotent Stem Cells. Trends in Cancer. 2: 485-494. PMID 27722205 DOI: 10.1016/J.Trecan.2016.07.007  0.749
2016 Lee DF, Walsh MJ, Aguiló F. ZNF217/ZFP217 Meets Chromatin and RNA. Trends in Biochemical Sciences. PMID 27519282 DOI: 10.1016/J.Tibs.2016.07.013  0.636
2016 Li CW, Xia W, Lim SO, Hsu JL, Huo L, Wu Y, Li LY, Lai CC, Chang SS, Hsu YH, Sun HL, Kim J, Yamaguchi H, Lee DF, Wang H, et al. AKT1 inhibits epithelial-to-mesenchymal transition in breast cancer through phosphorylation-dependent Twist1 degradation. Cancer Research. PMID 26759241 DOI: 10.1158/0008-5472.CAN-15-1941  0.78
2015 Aguilo F, Zhang F, Sancho A, Fidalgo M, Di Cecilia S, Vashisht A, Lee DF, Chen CH, Rengasamy M, Andino B, Jahouh F, Roman A, Krig SR, Wang R, Zhang W, et al. Coordination of m(6)A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming. Cell Stem Cell. PMID 26526723 DOI: 10.1016/J.Stem.2015.09.005  0.618
2015 Mulero-Navarro S, Sevilla A, Roman AC, Lee DF, D'Souza SL, Pardo S, Riess I, Su J, Cohen N, Schaniel C, Rodriguez NA, Baccarini A, Brown BD, Cavé H, Caye A, et al. Myeloid Dysregulation in a Human Induced Pluripotent Stem Cell Model of PTPN11-Associated Juvenile Myelomonocytic Leukemia. Cell Reports. 13: 504-515. PMID 26456833 DOI: 10.1016/J.Celrep.2015.09.019  0.724
2015 Gingold JA, Coakley ES, Su J, Lee DF, Lau Z, Zhou H, Felsenfeld DP, Schaniel C, Lemischka IR. Distribution Analyzer, a methodology for identifying and clustering outlier conditions from single-cell distributions, and its application to a Nanog reporter RNAi screen. Bmc Bioinformatics. 16: 225. PMID 26198214 DOI: 10.1186/S12859-015-0636-7  0.694
2015 Waghray A, Saiz N, Jayaprakash AD, Freire AG, Papatsenko D, Pereira CF, Lee DF, Brosh R, Chang B, Darr H, Gingold J, Kelley K, Schaniel C, Hadjantonakis AK, Lemischka IR. Tbx3 Controls Dppa3 Levels and Exit from Pluripotency toward Mesoderm. Stem Cell Reports. 5: 97-110. PMID 26095607 DOI: 10.1016/J.Stemcr.2015.05.009  0.751
2015 Ding J, Huang X, Shao N, Zhou H, Lee DF, Faiola F, Fidalgo M, Guallar D, Saunders A, Shliaha PV, Wang H, Waghray A, Papatsenko D, Sánchez-Priego C, Li D, et al. Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming. Cell Stem Cell. 16: 653-68. PMID 25936917 DOI: 10.1016/J.Stem.2015.04.001  0.747
2015 Lee DF, Su J, Kim HS, Chang B, Papatsenko D, Zhao R, Yuan Y, Gingold J, Xia W, Darr H, Mirzayans R, Hung MC, Schaniel C, Lemischka IR. Modeling familial cancer with induced pluripotent stem cells. Cell. 161: 240-54. PMID 25860607 DOI: 10.1016/J.Cell.2015.02.045  0.784
2014 Huo L, Li CW, Huang TH, Lam YC, Xia W, Tu C, Chang WC, Hsu JL, Lee DF, Nie L, Yamaguchi H, Wang Y, Lang J, Li LY, Chen CH, et al. Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells. American Journal of Translational Research. 6: 649-63. PMID 25628777  0.701
2014 Gingold JA, Fidalgo M, Guallar D, Lau Z, Sun Z, Zhou H, Faiola F, Huang X, Lee DF, Waghray A, Schaniel C, Felsenfeld DP, Lemischka IR, Wang J. A genome-wide RNAi screen identifies opposing functions of Snai1 and Snai2 on the Nanog dependency in reprogramming. Molecular Cell. 56: 140-52. PMID 25240402 DOI: 10.1016/J.Molcel.2014.08.014  0.744
2014 Kim HS, Bernitz JM, Lee DF, Lemischka IR. Genomic editing tools to model human diseases with isogenic pluripotent stem cells. Stem Cells and Development. 23: 2673-86. PMID 25075441 DOI: 10.1089/Scd.2014.0167  0.717
2013 Kuo HP, Wang Z, Lee DF, Iwasaki M, Duque-Afonso J, Wong SH, Lin CH, Figueroa ME, Su J, Lemischka IR, Cleary ML. Epigenetic roles of MLL oncoproteins are dependent on NF-κB. Cancer Cell. 24: 423-37. PMID 24054986 DOI: 10.1016/J.Ccr.2013.08.019  0.804
2012 Lee DF, Su J, Ang YS, Carvajal-Vergara X, Mulero-Navarro S, Pereira CF, Gingold J, Wang HL, Zhao R, Sevilla A, Darr H, Williamson AJ, Chang B, Niu X, Aguilo F, et al. Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell. 11: 179-94. PMID 22862944 DOI: 10.1016/J.Stem.2012.05.020  0.82
2012 Lee DF, Su J, Sevilla A, Gingold J, Schaniel C, Lemischka IR. Combining competition assays with genetic complementation strategies to dissect mouse embryonic stem cell self-renewal and pluripotency. Nature Protocols. 7: 729-48. PMID 22441292 DOI: 10.1038/Nprot.2012.018  0.733
2012 Wang Y, Ding Q, Yen CJ, Xia W, Izzo JG, Lang JY, Li CW, Hsu JL, Miller SA, Wang X, Lee DF, Hsu JM, Huo L, Labaff AM, Liu D, et al. The crosstalk of mTOR/S6K1 and Hedgehog pathways. Cancer Cell. 21: 374-87. PMID 22439934 DOI: 10.1016/j.ccr.2011.12.028  0.703
2012 Ling J, Kang Y, Zhao R, Xia Q, Lee DF, Chang Z, Li J, Peng B, Fleming JB, Wang H, Liu J, Lemischka IR, Hung MC, Chiao PJ. KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer Cell. 21: 105-20. PMID 22264792 DOI: 10.1016/J.Ccr.2011.12.006  0.725
2012 Liu M, Lee DF, Chen CT, Yen CJ, Li LY, Lee HJ, Chang CJ, Chang WC, Hsu JM, Kuo HP, Xia W, Wei Y, Chiu PC, Chou CK, Du Y, et al. IKKα activation of NOTCH links tumorigenesis via FOXA2 suppression. Molecular Cell. 45: 171-84. PMID 22196886 DOI: 10.1016/J.Molcel.2011.11.018  0.818
2011 Ding Q, Chang CJ, Xie X, Xia W, Yang JY, Wang SC, Wang Y, Xia J, Chen L, Cai C, Li H, Yen CJ, Kuo HP, Lee DF, Lang J, et al. APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis. The Journal of Clinical Investigation. 121: 4526-36. PMID 21985787 DOI: 10.1172/Jci45008  0.77
2011 Su JL, Cheng X, Yamaguchi H, Chang YW, Hou CF, Lee DF, Ko HW, Hua KT, Wang YN, Hsiao M, Chen PB, Hsu JM, Bast RC, Hortobagyi GN, Hung MC. FOXO3a-Dependent Mechanism of E1A-Induced Chemosensitization. Cancer Research. 71: 6878-87. PMID 21911455 DOI: 10.1158/0008-5472.Can-11-0295  0.812
2011 Zhang X, Yalcin S, Lee DF, Yeh TY, Lee SM, Su J, Mungamuri SK, Rimmelé P, Kennedy M, Sellers R, Landthaler M, Tuschl T, Chi NW, Lemischka I, Keller G, et al. FOXO1 is an essential regulator of pluripotency in human embryonic stem cells. Nature Cell Biology. 13: 1092-9. PMID 21804543 DOI: 10.1038/Ncb2293  0.769
2011 Tsai SY, Bouwman BA, Ang YS, Kim SJ, Lee DF, Lemischka IR, Rendl M. Single transcription factor reprogramming of hair follicle dermal papilla cells to induced pluripotent stem cells. Stem Cells (Dayton, Ohio). 29: 964-71. PMID 21563278 DOI: 10.1002/Stem.649  0.806
2011 Ang YS, Tsai SY, Lee DF, Monk J, Su J, Ratnakumar K, Ding J, Ge Y, Darr H, Chang B, Wang J, Rendl M, Bernstein E, Schaniel C, Lemischka IR. Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network. Cell. 145: 183-97. PMID 21477851 DOI: 10.1016/J.Cell.2011.03.003  0.807
2011 Aguilo F, Avagyan S, Labar A, Sevilla A, Lee DF, Kumar P, Lemischka IR, Zhou BY, Snoeck HW. Prdm16 is a physiologic regulator of hematopoietic stem cells. Blood. 117: 5057-66. PMID 21343612 DOI: 10.1182/Blood-2010-08-300145  0.749
2011 Zhao R, Yeung SC, Chen J, Iwakuma T, Su CH, Chen B, Qu C, Zhang F, Chen YT, Lin YL, Lee DF, Jin F, Zhu R, Shaikenov T, Sarbassov D, et al. Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers. The Journal of Clinical Investigation. 121: 851-65. PMID 21317535 DOI: 10.1172/Jci44111  0.653
2010 Schaniel C, Lee DF, Lemischka IR. Exploration of self-renewal and pluripotency in ES cells using RNAi. Methods in Enzymology. 477: 351-65. PMID 20699150 DOI: 10.1016/S0076-6879(10)77018-X  0.743
2010 Carvajal-Vergara X, Sevilla A, D'Souza SL, Ang YS, Schaniel C, Lee DF, Yang L, Kaplan AD, Adler ED, Rozov R, Ge Y, Cohen N, Edelmann LJ, Chang B, Waghray A, et al. Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature. 465: 808-12. PMID 20535210 DOI: 10.1038/Nature09005  0.8
2010 Kuo HP, Lee DF, Chen CT, Liu M, Chou CK, Lee HJ, Du Y, Xie X, Wei Y, Xia W, Weihua Z, Yang JY, Yen CJ, Huang TH, Tan M, et al. ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway. Science Signaling. 3: ra9. PMID 20145209 DOI: 10.1126/Scisignal.2000590  0.805
2010 Tsai SY, Clavel C, Kim S, Ang YS, Grisanti L, Lee DF, Kelley K, Rendl M. Oct4 and klf4 reprogram dermal papilla cells into induced pluripotent stem cells. Stem Cells (Dayton, Ohio). 28: 221-8. PMID 20014278 DOI: 10.1002/Stem.281  0.765
2009 Lee DF, Kuo HP, Liu M, Chou CK, Xia W, Du Y, Shen J, Chen CT, Huo L, Hsu MC, Li CW, Ding Q, Liao TL, Lai CC, Lin AC, et al. KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta. Molecular Cell. 36: 131-40. PMID 19818716 DOI: 10.1016/J.Molcel.2009.07.025  0.81
2009 Kuo HP, Lee DF, Xia W, Wei Y, Hung MC. TNFalpha induces HIF-1alpha expression through activation of IKKbeta. Biochemical and Biophysical Research Communications. 389: 640-4. PMID 19766100 DOI: 10.1016/j.bbrc.2009.09.042  0.785
2009 Kuo HP, Lee DF, Xia W, Lai CC, Li LY, Hung MC. Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation. Biochemical and Biophysical Research Communications. 389: 156-61. PMID 19716809 DOI: 10.1016/j.bbrc.2009.08.127  0.817
2009 Chou CK, Lee DF, Sun HL, Li LY, Lin CY, Huang WC, Hsu JM, Kuo HP, Yamaguchi H, Wang YN, Liu M, Wu HY, Liao PC, Yen CJ, Hung MC. The suppression of MAD1 by AKT-mediated phosphorylation activates MAD1 target genes transcription. Molecular Carcinogenesis. 48: 1048-58. PMID 19526459 DOI: 10.1002/Mc.20557  0.811
2008 Lee DF, Kuo HP, Chen CT, Wei Y, Chou CK, Hung JY, Yen CJ, Hung MC. IKKbeta suppression of TSC1 function links the mTOR pathway with insulin resistance. International Journal of Molecular Medicine. 22: 633-8. PMID 18949383 DOI: 10.3892/ijmm_00000065  0.777
2008 Lee DF, Hung MC. Advances in targeting IKK and IKK-related kinases for cancer therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 5656-62. PMID 18794072 DOI: 10.1158/1078-0432.CCR-08-0123  0.712
2008 Ding Q, Huo L, Yang JY, Xia W, Wei Y, Liao Y, Chang CJ, Yang Y, Lai CC, Lee DF, Yen CJ, Chen YJ, Hsu JM, Kuo HP, Lin CY, et al. Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer. Cancer Research. 68: 6109-17. PMID 18676833 DOI: 10.1158/0008-5472.CAN-08-0579  0.819
2008 Yen CJ, Izzo JG, Lee DF, Guha S, Wei Y, Wu TT, Chen CT, Kuo HP, Hsu JM, Sun HL, Chou CK, Buttar NS, Wang KK, Huang P, Ajani J, et al. Bile acid exposure up-regulates tuberous sclerosis complex 1/mammalian target of rapamycin pathway in Barrett's-associated esophageal adenocarcinoma. Cancer Research. 68: 2632-40. PMID 18413730 DOI: 10.1158/0008-5472.Can-07-5460  0.804
2008 Yang JY, Zong CS, Xia W, Yamaguchi H, Ding Q, Xie X, Lang JY, Lai CC, Chang CJ, Huang WC, Huang H, Kuo HP, Lee DF, Li LY, Lien HC, et al. ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nature Cell Biology. 10: 138-48. PMID 18204439 DOI: 10.1038/Ncb1676  0.791
2007 Lee DF, Hung MC. All roads lead to mTOR: integrating inflammation and tumor angiogenesis. Cell Cycle (Georgetown, Tex.). 6: 3011-4. PMID 18073529 DOI: 10.4161/cc.6.24.5085  0.709
2007 Lee DF, Kuo HP, Chen CT, Hsu JM, Chou CK, Wei Y, Sun HL, Li LY, Ping B, Huang WC, He X, Hung JY, Lai CC, Ding Q, Su JL, et al. IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell. 130: 440-55. PMID 17693255 DOI: 10.1016/j.cell.2007.05.058  0.803
2007 Ding Q, He X, Xia W, Hsu JM, Chen CT, Li LY, Lee DF, Yang JY, Xie X, Liu JC, Hung MC. Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer. Cancer Research. 67: 4564-71. PMID 17495324 DOI: 10.1158/0008-5472.CAN-06-1788  0.806
2007 Ding Q, He X, Hsu JM, Xia W, Chen CT, Li LY, Lee DF, Liu JC, Zhong Q, Wang X, Hung MC. Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization. Molecular and Cellular Biology. 27: 4006-17. PMID 17387146 DOI: 10.1128/Mcb.00620-06  0.663
2006 Ping B, He X, Xia W, Lee DF, Wei Y, Yu D, Mills G, Shi D, Hung MC. Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers. International Journal of Oncology. 29: 1103-10. PMID 17016640  0.762
2005 Giri DK, Ali-Seyed M, Li LY, Lee DF, Ling P, Bartholomeusz G, Wang SC, Hung MC. Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor. Molecular and Cellular Biology. 25: 11005-18. PMID 16314522 DOI: 10.1128/MCB.25.24.11005-11018.2005  0.662
2005 Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin J, Lai CC, Tsai FJ, Tsai CH, et al. Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Molecular Cell. 19: 159-70. PMID 16039586 DOI: 10.1016/j.molcel.2005.06.009  0.776
2005 Shao R, Lee DF, Wen Y, Ding Y, Xia W, Ping B, Yagita H, Spohn B, Hung MC. E1A sensitizes cancer cells to TRAIL-induced apoptosis through enhancement of caspase activation. Molecular Cancer Research : McR. 3: 219-26. PMID 15831675 DOI: 10.1158/1541-7786.Mcr-04-0084  0.767
2004 Wang SC, Lien HC, Xia W, Chen IF, Lo HW, Wang Z, Ali-Seyed M, Lee DF, Bartholomeusz G, Ou-Yang F, Giri DK, Hung MC. Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2. Cancer Cell. 6: 251-61. PMID 15380516 DOI: 10.1016/j.ccr.2004.07.012  0.718
2004 Xia W, Chen JS, Zhou X, Sun PR, Lee DF, Liao Y, Zhou BP, Hung MC. Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 3815-24. PMID 15173090 DOI: 10.1158/1078-0432.CCR-03-0527  0.686
2004 Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, Yang JY, Zou Y, Bao S, Hanada N, Saso H, Kobayashi R, Hung MC. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell. 117: 225-37. PMID 15084260 DOI: 10.1016/S0092-8674(04)00302-2  0.823
2004 Yan DH, Wen Y, Su LK, Xia W, Wang SC, Zhang S, Gan L, Lee DF, Spohn B, Frey JA, Hortobagyi GN, Hung MC. A delayed chemically induced tumorigenesis in Brca2 mutant mice. Oncogene. 23: 1896-901. PMID 14981540 DOI: 10.1038/sj.onc.1207314  0.772
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