Sanja Sever, Ph.D. - Publications

Affiliations: 
Massachusetts General Hospital, Boston, MA 

42/76 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Zhu K, Mukherjee K, Wei C, Hayek SS, Collins A, Gu C, Corapi K, Altintas MM, Wang Y, Waikar SS, Bianco AC, Koch A, Tacke F, Reiser J, Sever S. The D2D3 form of uPAR acts as an immunotoxin and may cause diabetes and kidney disease. Science Translational Medicine. 15: eabq6492. PMID 37729431 DOI: 10.1126/scitranslmed.abq6492  0.428
2022 Mukherjee K, Gu C, Collins A, Mettlen M, Samelko B, Altintas MM, Sudhini YR, Wang X, Bouley R, Brown D, Pedro BP, Bane SL, Gupta V, Brinkkoetter PT, Hagmann H, ... ... Sever S, et al. Simultaneous stabilization of actin cytoskeleton in multiple nephron-specific cells protects the kidney from diverse injury. Nature Communications. 13: 2422. PMID 35504916 DOI: 10.1038/s41467-022-30101-4  0.485
2020 Sever S. Role of actin cytoskeleton in podocytes. Pediatric Nephrology (Berlin, Germany). PMID 33188449 DOI: 10.1007/s00467-020-04812-z  0.328
2020 Hayek SS, Leaf DE, Samman Tahhan A, Raad M, Sharma S, Waikar SS, Sever S, Camacho A, Wang X, Dande RR, Ibrahim NE, Baron RM, Altintas MM, Wei C, Sheikh-Hamad D, et al. Soluble Urokinase Receptor and Acute Kidney Injury. The New England Journal of Medicine. 382: 416-426. PMID 31995687 DOI: 10.1056/Nejmoa1911481  0.32
2019 Wei C, Li J, Adair BD, Zhu K, Cai J, Merchant M, Samelko B, Liao Z, Koh KH, Tardi NJ, Dande RR, Liu S, Ma J, DiBartolo S, Hägele S, ... ... Sever S, et al. uPAR isoform 2 forms a dimer and induces severe kidney disease in mice. The Journal of Clinical Investigation. PMID 30730305 DOI: 10.1172/Jci124793  0.368
2018 Sever S, Schiffer M. Actin dynamics at focal adhesions: a common endpoint and putative therapeutic target for proteinuric kidney diseases. Kidney International. PMID 29678354 DOI: 10.1016/J.Kint.2017.12.028  0.44
2017 Hayek SS, Ko YA, Awad M, Ahmed H, Gray B, Hosny KM, Aida H, Tracy MJ, Wei C, Sever S, Reiser J, Quyyumi AA. Cardiovascular Disease Biomarkers and suPAR in Predicting Decline in Renal Function: A Prospective Cohort Study. Kidney International Reports. 2: 425-432. PMID 29142970 DOI: 10.1016/J.Ekir.2017.02.001  0.31
2017 Sever S, Gu C. Podocytes and the actin cytoskeleton as a feasible therapeutic target Periodicum Biologorum. 118: 381-384. DOI: 10.18054/Pb.V118I4.4576  0.371
2016 Hahm E, Wei C, Fernandez I, Li J, Tardi NJ, Tracy M, Wadhwani S, Cao Y, Peev V, Zloza A, Lusciks J, Hayek SS, O'Connor C, Bitzer M, Gupta V, ... Sever S, et al. Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease. Nature Medicine. PMID 27941791 DOI: 10.1038/Nm.4242  0.372
2016 Lee H, Noh H, Mun J, Gu C, Sever S, Park S. Anks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis. Nature Communications. 7: 12799. PMID 27619642 DOI: 10.1038/Ncomms12799  0.492
2016 Gu C, Lee HW, Garborcauskas G, Reiser J, Gupta V, Sever S. Dynamin Autonomously Regulates Podocyte Focal Adhesion Maturation. Journal of the American Society of Nephrology : Jasn. PMID 27432739 DOI: 10.1681/Asn.2016010008  0.56
2015 Hayek SS, Sever S, Ko YA, Trachtman H, Awad M, Wadhwani S, Altintas MM, Wei C, Hotton AL, French AL, Sperling LS, Lerakis S, Quyyumi AA, Reiser J. Soluble Urokinase Receptor and Chronic Kidney Disease. The New England Journal of Medicine. 373: 1916-25. PMID 26539835 DOI: 10.1056/Nejmoa1506362  0.324
2015 Schiffer M, Teng B, Gu C, Shchedrina VA, Kasaikina M, Pham VA, Hanke N, Rong S, Gueler F, Schroder P, Tossidou I, Park JK, Staggs L, Haller H, Erschow S, ... ... Sever S, et al. Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models. Nature Medicine. 21: 601-9. PMID 25962121 DOI: 10.1038/Nm.3843  0.723
2015 Lee HW, Khan SQ, Faridi MH, Wei C, Tardi NJ, Altintas MM, Elshabrawy HA, Mangos S, Quick KL, Sever S, Reiser J, Gupta V. A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules. Journal of the American Society of Nephrology : Jasn. PMID 25858967 DOI: 10.1681/Asn.2014090859  0.31
2014 Trachtman H, Benzing T, Sever S, Harris RC, Reiser J. The grand challenge of nephrology. Frontiers in Medicine. 1: 28. PMID 25593903 DOI: 10.3389/Fmed.2014.00028  0.332
2014 Gu C, Chang J, Shchedrina VA, Pham VA, Hartwig JH, Suphamungmee W, Lehman W, Hyman BT, Bacskai BJ, Sever S. Regulation of dynamin oligomerization in cells: the role of dynamin-actin interactions and its GTPase activity. Traffic (Copenhagen, Denmark). 15: 819-38. PMID 24891099 DOI: 10.1111/Tra.12178  0.723
2014 Altintas MM, Moriwaki K, Wei C, Möller CC, Flesche J, Li J, Yaddanapudi S, Faridi MH, Gödel M, Huber TB, Preston RA, Jiang JX, Kerjaschki D, Sever S, Reiser J. Reduction of proteinuria through podocyte alkalinization. The Journal of Biological Chemistry. 289: 17454-67. PMID 24817115 DOI: 10.1074/Jbc.M114.568998  0.345
2013 Kistler AD, Singh G, Altintas MM, Yu H, Fernandez IC, Gu C, Wilson C, Srivastava SK, Dietrich A, Walz K, Kerjaschki D, Ruiz P, Dryer S, Sever S, Dinda AK, et al. Transient receptor potential channel 6 (TRPC6) protects podocytes during complement-mediated glomerular disease. The Journal of Biological Chemistry. 288: 36598-609. PMID 24194522 DOI: 10.1074/Jbc.M113.488122  0.536
2013 Sever S, Chang J, Gu C. Dynamin rings: not just for fission. Traffic (Copenhagen, Denmark). 14: 1194-9. PMID 23980695 DOI: 10.1111/Tra.12116  0.565
2013 Reiser J, Sever S. Podocyte biology and pathogenesis of kidney disease. Annual Review of Medicine. 64: 357-66. PMID 23190150 DOI: 10.1146/Annurev-Med-050311-163340  0.366
2012 Yaddanapudi S, Altintas MM, Kistler AD, Fernandez I, Möller CC, Wei C, Peev V, Flesche JB, Forst AL, Li J, Patrakka J, Xiao Z, Grahammer F, Schiffer M, Lohmüller T, ... ... Sever S, et al. CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival (The Journal of Clinical Investigation (2011) 121, 10, (3965-3980) DOI: 10.1172/JCI58552) Journal of Clinical Investigation. 122: 780. DOI: 10.1172/Jci62812  0.454
2012 Rayego-Mateos S, Rodrigues-Díez R, Rodrigues-Díez RR, Lavoz-Barria C, Alique M, Mas S, Pato J, Keri G, Egido J, Ortiz A, Ruiz-Ortega M, Ying L, Tepel M, Frank E, Florian T, ... ... Sever S, et al. Mechanisms and targets of glomerular damage Nephrology Dialysis Transplantation. 27. DOI: 10.1093/Ndt/Gfs229  0.437
2011 Yaddanapudi S, Altintas MM, Kistler AD, Fernandez I, Möller CC, Wei C, Peev V, Flesche JB, Forst AL, Li J, Patrakka J, Xiao Z, Grahammer F, Schiffer M, Lohmüller T, ... ... Sever S, et al. CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival. The Journal of Clinical Investigation. 121: 3965-80. PMID 21911934 DOI: 10.1172/Jci58552  0.56
2010 Gu C, Yaddanapudi S, Weins A, Osborn T, Reiser J, Pollak M, Hartwig J, Sever S. Direct dynamin-actin interactions regulate the actin cytoskeleton. The Embo Journal. 29: 3593-606. PMID 20935625 DOI: 10.1038/Emboj.2010.249  0.557
2010 Chiang WC, Geel TM, Altintas MM, Sever S, Ruiters MH, Reiser J. Establishment of protein delivery systems targeting podocytes. Plos One. 5: e11837. PMID 20686602 DOI: 10.1371/Journal.Pone.0011837  0.36
2010 Colvin RA, Means TK, Diefenbach TJ, Moita LF, Friday RP, Sever S, Campanella GS, Abrazinski T, Manice LA, Moita C, Andrews NW, Wu D, Hacohen N, Luster AD. Synaptotagmin-mediated vesicle fusion regulates cell migration. Nature Immunology. 11: 495-502. PMID 20473299 DOI: 10.1038/Ni.1878  0.331
2009 Adair BD, Altintas M, Möller CC, Flesche J, Wei C, Faul C, Campbell K, Gu C, Sever S, Shaw A, Mundel P, Reiser J. CD2AP Structure And Progression Of Renal Disease Biophysical Journal. 96: 132a-133a. DOI: 10.1016/J.Bpj.2008.12.601  0.539
2007 Sever S, Altintas MM, Nankoe SR, Möller CC, Ko D, Wei C, Henderson J, del Re EC, Hsing L, Erickson A, Cohen CD, Kretzler M, Kerjaschki D, Rudensky A, Nikolic B, et al. Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease. The Journal of Clinical Investigation. 117: 2095-104. PMID 17671649 DOI: 10.1172/Jci32022  0.379
2006 Nankoe SR, Sever S. Dynasore puts a new spin on dynamin: a surprising dual role during vesicle formation. Trends in Cell Biology. 16: 607-9. PMID 17064900 DOI: 10.1016/J.Tcb.2006.10.004  0.325
2006 Sever S, Skoch J, Newmyer S, Ramachandran R, Ko D, McKee M, Bouley R, Ausiello D, Hyman BT, Bacskai BJ. Physical and functional connection between auxilin and dynamin during endocytosis. The Embo Journal. 25: 4163-74. PMID 16946707 DOI: 10.1038/Sj.Emboj.7601298  0.393
2005 Sever S, Skoch J, Bacskai BJ, Newmyer SL. Assays and functional properties of auxilin-dynamin interactions. Methods in Enzymology. 404: 570-85. PMID 16413301 DOI: 10.1016/S0076-6879(05)04050-4  0.346
2003 Sever S. AP-2 makes room for rivals. Developmental Cell. 5: 530-2. PMID 14536052 DOI: 10.1016/S1534-5807(03)00304-6  0.312
2003 Newmyer SL, Christensen A, Sever S. Auxilin-dynamin interactions link the uncoating ATPase chaperone machinery with vesicle formation. Developmental Cell. 4: 929-40. PMID 12791276 DOI: 10.1016/S1534-5807(03)00157-6  0.368
2002 Sever S. Dynamin and endocytosis. Current Opinion in Cell Biology. 14: 463-7. PMID 12383797 DOI: 10.1016/S0955-0674(02)00347-2  0.358
2001 Damke H, Muhlberg AB, Sever S, Sholly S, Warnock DE, Schmid SL. Expression, purification, and functional assays for self-association of dynamin-1. Methods in Enzymology. 329: 447-57. PMID 11210565 DOI: 10.1016/S0076-6879(01)29106-X  0.639
2000 Sever S, Damke H, Schmid SL. Garrotes, springs, ratchets, and whips: putting dynamin models to the test. Traffic (Copenhagen, Denmark). 1: 385-92. PMID 11208124 DOI: 10.1034/J.1600-0854.2000.010503.X  0.501
2000 Sever S, Damke H, Schmid SL. Dynamin:GTP controls the formation of constricted coated pits, the rate limiting step in clathrin-mediated endocytosis. The Journal of Cell Biology. 150: 1137-48. PMID 10974001 DOI: 10.1083/Jcb.150.5.1137  0.541
1999 Ibba M, Sever S, Praetorius-Ibba M, Söll D. Transfer RNA identity contributes to transition state stabilization during aminoacyl-tRNA synthesis. Nucleic Acids Research. 27: 3631-7. PMID 10471730 DOI: 10.1093/Nar/27.18.3631  0.426
1999 Sever S, Muhlberg AB, Schmid SL. Impairment of dynamin's GAP domain stimulates receptor-mediated endocytosis. Nature. 398: 481-6. PMID 10206643 DOI: 10.1038/19024  0.552
1996 Ibba M, Hong KW, Sherman JM, Sever S, Söll D. Interactions between tRNA identity nucleotides and their recognition sites in glutaminyl-tRNA synthetase determine the cognate amino acid affinity of the enzyme. Proceedings of the National Academy of Sciences of the United States of America. 93: 6953-8. PMID 8692925 DOI: 10.1073/Pnas.93.14.6953  0.439
1996 Sever S, Rogers K, Rogers MJ, Carter C, Söll D. Escherichia coli tryptophanyl-tRNA synthetase mutants selected for tryptophan auxotrophy implicate the dimer interface in optimizing amino acid binding. Biochemistry. 35: 32-40. PMID 8555191 DOI: 10.1021/Bi952103D  0.461
1995 Ibba M, Thomann HU, Hong KW, Sherman JM, Weygand-Durasevic I, Sever S, Stange-Thomann N, Praetorius M, Söll D. Substrate selection by aminoacyl-tRNA synthetases. Nucleic Acids Symposium Series. 40-2. PMID 8643392  0.38
Low-probability matches (unlikely to be authored by this person)
2005 von Arnim CA, Kinoshita A, Peltan ID, Tangredi MM, Herl L, Lee BM, Spoelgen R, Hshieh TT, Ranganathan S, Battey FD, Liu CX, Bacskai BJ, Sever S, Irizarry MC, Strickland DK, et al. The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate. The Journal of Biological Chemistry. 280: 17777-85. PMID 15749709 DOI: 10.1074/Jbc.M414248200  0.298
2017 Schaefer F, Trachtman H, Wühl E, Kirchner M, Hayek SS, Anarat A, Duzova A, Mir S, Paripovic D, Yilmaz A, Lugani F, Arbeiter K, Litwin M, Oh J, Matteucci MC, ... ... Sever S, et al. Association of Serum Soluble Urokinase Receptor Levels With Progression of Kidney Disease in Children. Jama Pediatrics. e172914. PMID 28873129 DOI: 10.1001/Jamapediatrics.2017.2914  0.297
2017 Hayek SS, Koh KH, Grams ME, Wei C, Ko YA, Li J, Samelko B, Lee H, Dande RR, Lee HW, Hahm E, Peev V, Tracy M, Tardi NJ, Gupta V, ... ... Sever S, et al. A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease. Nature Medicine. PMID 28650456 DOI: 10.1038/Nm.4362  0.291
2014 Reiser J, Sever S, Faul C. Signal transduction in podocytes--spotlight on receptor tyrosine kinases. Nature Reviews. Nephrology. 10: 104-15. PMID 24394191 DOI: 10.1038/Nrneph.2013.274  0.291
2017 Drechsler C, Hayek SS, Wei C, Sever S, Genser B, Krane V, Meinitzer A, März W, Wanner C, Reiser J. Soluble Urokinase Plasminogen Activator Receptor and Outcomes in Patients with Diabetes on Hemodialysis. Clinical Journal of the American Society of Nephrology : Cjasn. PMID 28495863 DOI: 10.2215/Cjn.10881016  0.29
2016 Müller-Deile J, Teng B, Schenk H, Haller H, Reiser J, Sever S, Schiffer M. Drugs targeting dynamin can restore cytoskeleton and focal contact alterations of urinary podocytes derived from patients with nephrotic syndrome. Annals of Translational Medicine. 4: 439. PMID 27942530 DOI: 10.21037/Atm.2016.10.72  0.29
2013 Sever S, Trachtman H, Wei C, Reiser J. Is there clinical value in measuring suPAR levels in FSGS? Clinical Journal of the American Society of Nephrology : Cjasn. 8: 1273-5. PMID 23886567 DOI: 10.2215/Cjn.06170613  0.27
2017 Alasfar S, Matar D, Montgomery RA, Desai N, Lonze B, Vujjini V, Estrella MM, Dieck JM, Khneizer G, Sever S, Reiser J, Alachkar N. Rituximab and Therapeutic Plasma Exchange in Recurrent Focal Segmental Glomerulosclerosis Postkidney Transplantation. Transplantation. PMID 29189487 DOI: 10.1097/Tp.0000000000002008  0.258
2010 Conery AR, Sever S, Harlow E. Nucleoside diphosphate kinase Nm23-H1 regulates chromosomal stability by activating the GTPase dynamin during cytokinesis. Proceedings of the National Academy of Sciences of the United States of America. 107: 15461-6. PMID 20713695 DOI: 10.1073/Pnas.1010633107  0.248
2015 Sever S, Reiser J. CD2AP, Dendrin, and Cathepsin L in the Kidney. The American Journal of Pathology. 185: 3129-30. PMID 26506476 DOI: 10.1016/J.Ajpath.2015.06.022  0.247
2023 Polat OK, Isaeva E, Sudhini YR, Knott B, Zhu K, Noben M, Suresh Kumar V, Endlich N, Mangos S, Reddy TV, Samelko B, Wei C, Altintas MM, Dryer SE, Sever S, et al. The small GTPase regulatory protein Rac1 drives podocyte injury independent of cationic channel protein TRPC5. Kidney International. PMID 36750145 DOI: 10.1016/j.kint.2023.01.016  0.226
2021 Mukherjee K, Chio TI, Gu H, Sackett DL, Bane SL, Sever S. A Novel Fluorogenic Assay for the Detection of Nephrotoxin-Induced Oxidative Stress in Live Cells and Renal Tissue. Acs Sensors. PMID 34214393 DOI: 10.1021/acssensors.1c00422  0.15
2021 Mukherjee K, Chio TI, Gu H, Sackett DL, Bane SL, Sever S. A Novel Fluorogenic Assay for the Detection of Nephrotoxin-Induced Oxidative Stress in Live Cells and Renal Tissue. Acs Sensors. PMID 34214393 DOI: 10.1021/acssensors.1c00422  0.15
1997 Warnock DE, Muhlberg SB, Sever S, Schmid SL. Regulation of the dynamin GTPase cycle Faseb Journal. 11: A1011.  0.136
2017 Alasfar S, Matar D, Montgomery RA, Desai N, Lonze B, Vujjini V, Estrella MM, Dieck JM, Khneizer G, Sever S, Reiser J, Alachkar N. Rituximab and Therapeutic Plasma Exchange in Recurrent Focal Segmental Glomerulosclerosis Postkidney Transplantation. Transplantation. PMID 29189487 DOI: 10.1097/TP.0000000000002008  0.119
2005 Einhorn-Stoll U, Ulbrich M, Sever S, Kunzek H. Formation of milk protein-pectin conjugates with improved emulsifying properties by controlled dry heating Food Hydrocolloids. 19: 329-340. DOI: 10.1016/j.foodhyd.2004.07.005  0.079
2012 Sever S, Weinstein DA, Wolfsdorf JI, Gedik R, Schaefer EJ. Glycogen storage disease type Ia: linkage of glucose, glycogen, lactic acid, triglyceride, and uric acid metabolism. Journal of Clinical Lipidology. 6: 596-600. PMID 23312056 DOI: 10.1016/j.jacl.2012.08.005  0.072
2006 Tükenmez Demirci G, Yaşar S, Mansur AT, Esen Aydingöz I, Sever S. Prepubertal Fox-Fordyce disease: A case report | Prepubertal Fox-Fordyce hastaliǧi Turkiye Klinikleri Journal of Medical Sciences. 26: 338-341.  0.06
1995 Sever S. [The forestry work environment and its ergonomic requirements]. Arhiv Za Higijenu Rada I Toksikologiju. 46: 95-110. PMID 7575151  0.052
2004 Sever S. Počasnica prvome znanstveniku u strojarstvu - Slavodobitniku Državne nagrade tehničke kulture Faust Vrančić Polimeri (Zagreb). 25: 151.  0.023
2013 Sever S, Oguz-Unver A, Yurumezoglu K. The effective presentation of inquiry-based classroom experiments using teaching strategies that employ video and demonstration methods Australasian Journal of Educational Technology. 29: 450-463.  0.022
2012 Sever SM, Kazancioǧlu R. Once more - Still another disaster: The Van earthquake | Van depremi'nin ardindan: Yine yeniden deprem Turkish Nephrology, Dialysis and Transplantation Journal. 21: 7-9. DOI: 10.5262/tndt.2012.1001.02  0.021
1955 SEVER S. [Requirements of a specialist from a district physician]. Praktický LéKar̆. 35: 370-1. PMID 13266697  0.018
2010 Sever S, Yurumezoglu K, Oguz-Unver A. Comparison teaching strategies of videotaped and demonstration experiments in inquiry-based science education Procedia - Social and Behavioral Sciences. 2: 5619-5624. DOI: 10.1016/j.sbspro.2010.03.916  0.015
2015 Sever S. Primary school students’ musical images in their pictures and its’ relationship with the music lessons at school | İlköğretim Öğrencilerinin resimsel anlatımlarında müzik İmgesi ve okuldaki müzik dersiyle İlişkisi Elementary Education Online. 14: 538-556. DOI: 10.17051/io.2015.63556  0.012
2011 Panaitescu D, Ciuprina F, Iorga M, Frone A, Radovici C, Ghiurea M, Sever S, Plesa I. Effects of SiO 2 and Al 2O 3 nanofillers on polyethylene properties Journal of Applied Polymer Science. 122: 1921-1935. DOI: 10.1002/app.34297  0.012
2014 Sever S. Horizontal effect and the charter Croatian Yearbook of European Law and Policy. 10: 39-65.  0.01
2011 Kurumer G, Karabay G, Sever S. A research on workers selection and training in apparel industry Tekstil Ve Konfeksiyon. 21: 171-175.  0.01
2010 Seeck-Hirschner M, Baier PC, Sever S, Buschbacher A, Aldenhoff JB, Göder R. Effects of daytime naps on procedural and declarative memory in patients with schizophrenia. Journal of Psychiatric Research. 44: 42-7. PMID 19559446 DOI: 10.1016/j.jpsychires.2009.05.008  0.01
2008 Tušek B, Sever S. Development and perspectives of internal auditing in the improvement of business quality of enterprises - Empirical research in croatia Ekonomska Istrazivanja. 21: 82-95.  0.01
2008 Sačer IM, Sever S, Oluić A. The possibilities of implementing the IFRS for small and medium-sized entities - An analysis | Analiza mogućnosti primjene MSFI-a za mala i srednja poduzeća Ekonomski Pregled. 59: 103-124.  0.01
2007 Furman M, Malovrh S, Sever S, Kovač M. The effect of genotype and sex on pork quality Poljoprivreda. 13: 51-54.  0.01
2007 Sever S. Naraštajnikova počasnica životu i djelu: O sedamdesetoj obljetnici života Igora Čatića Polimeri (Zagreb). 28: 26.  0.01
2005 Sever S, Puljak S. TIBOTRAC FM 03 - The first Croatian skidder powered by biodiesel fuel | TIBOTRAC FM 03 - Prvi hrvatski šumski zglobnik na biodizelsko gorivo Nova Mehanizacija Sumarstva. 26: 3-12.  0.01
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