Jerry Kaplan - Publications

Affiliations: 
Pathology University of Utah, Salt Lake City, UT 
Area:
Metal Metabolism, Cell Biology
Website:
http://medicine.utah.edu/faculty/mddetail.php?facultyID=u0028195

119 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Seguin A, Jia X, Earl AM, Li L, Wallace J, Qiu A, Bradley T, Shrestha R, Troadec MB, Hockin M, Titen S, Warner DE, Dowdle PT, Wohlfahrt ME, Hillas E, ... ... Kaplan J, et al. The mitochondrial metal transporters mitoferrin1 and mitoferrin2 are required for liver regeneration and cell proliferation in mice. The Journal of Biological Chemistry. PMID 32518166 DOI: 10.1074/jbc.RA120.013229  0.6
2020 Li L, Bertram S, Kaplan J, Jia X, Ward DM. The mitochondrial iron exporter genes MMT1 and MMT2 in yeast are transcriptionally regulated by Aft1 and Yap1. The Journal of Biological Chemistry. PMID 31896574 DOI: 10.1074/jbc.RA119.011154  0.6
2018 Yien YY, Shi J, Chen C, Cheung JT, Grillo AS, Shrestha R, Li L, Zhang X, Kafina MD, Kingsley PD, King MJ, Ablain J, Li H, Zon L, Palis J, ... ... Kaplan J, et al. FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity. The Journal of Biological Chemistry. PMID 30366982 DOI: 10.1074/jbc.RA118.002742  0.6
2018 Ward DM, Chen OS, Li L, Kaplan J, Bhuiyan SA, Natarajan SK, Bard M, Cox JE. Altered sterol metabolism in budding yeast affects mitochondrial iron-sulfur (Fe-S) cluster synthesis. The Journal of Biological Chemistry. PMID 29773647 DOI: 10.1074/jbc.RA118.001781  0.6
2017 Seguin A, Takahashi-Makise N, Yien YY, Huston NC, Whitman JC, Musso G, Wallace JA, Bradley T, Bergonia H, Kafina MD, Matsumoto M, Igarashi K, Phillips JD, Paw BH, Kaplan J, et al. Reductions in the mitochondrial ABC transporter Abcb10 affect the transcriptional profile of heme biosynthesis genes. The Journal of Biological Chemistry. PMID 28808058 DOI: 10.1074/jbc.M117.797415  0.6
2017 Li L, Kaplan J, Ward DM. The glucose sensor Snf1 and the transcription factors Msn2 and Msn4 regulate transcription of the vacuolar iron importer gene CCC1 and iron resistance in yeast. The Journal of Biological Chemistry. PMID 28760824 DOI: 10.1074/jbc.M117.802504  0.6
2017 Yaish HM, Farrell CP, Christensen RD, MacQueen BC, Jackson LK, Trochez-Enciso J, Kaplan J, Ward DM, Salah WK, Phillips JD. Two novel mutations in TMPRSS6 associated with iron-refractory iron deficiency anemia in a mother and child. Blood Cells, Molecules & Diseases. 65: 38-40. PMID 28460265 DOI: 10.1016/j.bcmd.2017.04.002  0.6
2015 Kaplan J, Ward DM. Muscle specific iron deficiency has systemic consequences. Ebiomedicine. 2: 1582-3. PMID 26870775 DOI: 10.1016/j.ebiom.2015.10.001  0.6
2015 Kaplan J, Ward DM. Muscle specific iron deficiency has systemic consequences Ebiomedicine. DOI: 10.1016/j.ebiom.2015.10.001  0.96
2014 Yien YY, Robledo RF, Schultz IJ, Takahashi-Makise N, Gwynn B, Bauer DE, Dass A, Yi G, Li L, Hildick-Smith GJ, Cooney JD, Pierce EL, Mohler K, Dailey TA, Miyata N, ... ... Kaplan J, et al. TMEM14C is required for erythroid mitochondrial heme metabolism. The Journal of Clinical Investigation. 124: 4294-304. PMID 25157825 DOI: 10.1172/JCI76979  0.96
2014 Li L, Miao R, Jia X, Ward DM, Kaplan J. Expression of the yeast cation diffusion facilitators Mmt1 and Mmt2 affects mitochondrial and cellular iron homeostasis: evidence for mitochondrial iron export. The Journal of Biological Chemistry. 289: 17132-41. PMID 24798331 DOI: 10.1074/jbc.M114.574723  0.96
2014 Chung J, Anderson SA, Gwynn B, Deck KM, Chen MJ, Langer NB, Shaw GC, Huston NC, Boyer LF, Datta S, Paradkar PN, Li L, Wei Z, Lambert AJ, Sahr K, ... ... Kaplan J, et al. Iron regulatory protein-1 protects against mitoferrin-1-deficient porphyria. The Journal of Biological Chemistry. 289: 7835-43. PMID 24509859 DOI: 10.1074/jbc.A114.547778  0.96
2014 Ben-Othman R, Flannery AR, Miguel DC, Ward DM, Kaplan J, Andrews NW. Leishmania-mediated inhibition of iron export promotes parasite replication in macrophages. Plos Pathogens. 10: e1003901. PMID 24497831 DOI: 10.1371/journal.ppat.1003901  0.96
2013 Kaplan J, Ward DM. The essential nature of iron usage and regulation. Current Biology : Cb. 23: 2325. PMID 30001585 DOI: 10.1016/j.cub.2013.10.059  0.6
2013 Kaplan J, Ward DM. The essential nature of iron usage and regulation. Current Biology : Cb. 23: R642-6. PMID 23928078 DOI: 10.1016/j.cub.2013.05.033  0.96
2013 Chen C, Garcia-Santos D, Ishikawa Y, Seguin A, Li L, Fegan KH, Hildick-Smith GJ, Shah DI, Cooney JD, Chen W, King MJ, Yien YY, Schultz IJ, Anderson H, Dalton AJ, ... ... Kaplan J, et al. Snx3 regulates recycling of the transferrin receptor and iron assimilation. Cell Metabolism. 17: 343-52. PMID 23416069 DOI: 10.1016/j.cmet.2013.01.013  0.96
2012 Shah DI, Takahashi-Makise N, Cooney JD, Li L, Schultz IJ, Pierce EL, Narla A, Seguin A, Hattangadi SM, Medlock AE, Langer NB, Dailey TA, Hurst SN, Faccenda D, Wiwczar JM, ... ... Kaplan J, et al. Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts. Nature. 491: 608-12. PMID 23135403 DOI: 10.1038/nature11536  0.96
2012 Li L, Miao R, Bertram S, Jia X, Ward DM, Kaplan J. A role for iron-sulfur clusters in the regulation of transcription factor Yap5-dependent high iron transcriptional responses in yeast. The Journal of Biological Chemistry. 287: 35709-21. PMID 22915593 DOI: 10.1074/jbc.M112.395533  0.96
2012 De Domenico I, Lo E, Yang B, Korolnek T, Hamza I, Ward DM, Kaplan J. Retraction notice to: The role of ubiquitination in hepcidin- independent and hepcidin-dependent degradation of ferroportin (Cell Metabolism (2011) 14, (635-646) DOI: 10.1016/j.cmet.2011.09.008) Cell Metabolism. 15: 927. PMID 22866335 DOI: 10.1016/j.cmet.2012.04.017  0.96
2012 De Domenico I, Vaughn MB, Paradkar PN, Lo E, Ward DM, Kaplan J. Retraction notice to: Decoupling ferritin synthesis from free cytosolic iron results in ferritin secretion (Cell Metabolism (2011) 13, (57-67) DOI: 10.1016/j.cmet.2010.12.003) Cell Metabolism. 15: 927. PMID 22866334 DOI: 10.1016/j.cmet.2012.04.012  0.96
2012 Polati R, Castagna A, Bossi AM, Alberio T, De Domenico I, Kaplan J, Timperio AM, Zolla L, Gevi F, D'Alessandro A, Brunch R, Olivieri O, Girelli D. Murine macrophages response to iron. Journal of Proteomics. 76: 10-27. PMID 22835775 DOI: 10.1016/j.jprot.2012.07.018  0.96
2012 Bagley DC, Paradkar PN, Kaplan J, Ward DM. Mon1a protein acts in trafficking through the secretory apparatus. The Journal of Biological Chemistry. 287: 25577-88. PMID 22665492 DOI: 10.1074/jbc.M112.354043  0.96
2012 Ward DM, Kaplan J. Ferroportin-mediated iron transport: expression and regulation. Biochimica Et Biophysica Acta. 1823: 1426-33. PMID 22440327 DOI: 10.1016/j.bbamcr.2012.03.004  0.96
2012 Durchfort N, Verhoef S, Vaughn MB, Shrestha R, Adam D, Kaplan J, Ward DM. The enlarged lysosomes in beige j cells result from decreased lysosome fission and not increased lysosome fusion. Traffic (Copenhagen, Denmark). 13: 108-19. PMID 21985295 DOI: 10.1111/j.1600-0854.2011.01300.x  0.96
2012 De Domenico I, Vaughn MB, Yoon D, Kushner JP, Ward DM, Kaplan J. Zebrafish as a model for defining the functional impact of mammalian ferroportin mutations (Blood (2007) 110, 10 (3780-3783)) Blood. 119: 5340. DOI: 10.1182/blood-2012-04-427054  0.96
2012 De Domenico I, Zhang TY, Koening CL, Branch RW, London N, Lo E, Daynes RA, Kushner JP, Li D, Ward DM, Kaplan J. Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice (Journal of Clinical Investigation (2010) 120, 7(2395-2405) DOI: 10.1172/JCI42011) Journal of Clinical Investigation. 122: 2326. DOI: 10.1172/JCI63977  0.96
2012 De Domenico I, Lo E, Ward DM, Kaplan J. Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2 (Proceedings of the National Academy of Sciences of the United States of America (2009) 106, (3800-3805) DOI: 10.1073/pnas.0900453106) Proceedings of the National Academy of Sciences of the United States of America. 109: 7583-7586. DOI: 10.1073/pnas.1205754109  0.96
2011 Seguin A, Ward DM, Kaplan J. Regulation of ribonucleotide reductase during iron limitation. Molecular Cell. 44: 683-4. PMID 22152471 DOI: 10.1016/j.molcel.2011.11.011  0.96
2011 De Domenico I, Lo E, Yang B, Korolnek T, Hamza I, Ward DM, Kaplan J. The role of ubiquitination in hepcidin-independent and hepcidin-dependent degradation of ferroportin. Cell Metabolism. 14: 635-46. PMID 22019085 DOI: 10.1016/j.cmet.2011.09.008  0.96
2011 Reeder NL, Kaplan J, Xu J, Youngquist RS, Wallace J, Hu P, Juhlin KD, Schwartz JR, Grant RA, Fieno A, Nemeth S, Reichling T, Tiesman JP, Mills T, Steinke M, et al. Zinc pyrithione inhibits yeast growth through copper influx and inactivation of iron-sulfur proteins. Antimicrobial Agents and Chemotherapy. 55: 5753-60. PMID 21947398 DOI: 10.1128/AAC.00724-11  0.96
2011 Li L, Jia X, Ward DM, Kaplan J. Yap5 protein-regulated transcription of the TYW1 gene protects yeast from high iron toxicity. The Journal of Biological Chemistry. 286: 38488-97. PMID 21917924 DOI: 10.1074/jbc.M111.286666  0.96
2011 De Domenico I, Ward DM, Kaplan J. Hepcidin and ferroportin: the new players in iron metabolism. Seminars in Liver Disease. 31: 272-9. PMID 21901657 DOI: 10.1055/s-0031-1286058  0.96
2011 Wang Y, Langer NB, Shaw GC, Yang G, Li L, Kaplan J, Paw BH, Bloomer JR. Abnormal mitoferrin-1 expression in patients with erythropoietic protoporphyria. Experimental Hematology. 39: 784-94. PMID 21627978 DOI: 10.1016/j.exphem.2011.05.003  0.96
2011 Troadec MB, Warner D, Wallace J, Thomas K, Spangrude GJ, Phillips J, Khalimonchuk O, Paw BH, Ward DM, Kaplan J. Targeted deletion of the mouse Mitoferrin1 gene: from anemia to protoporphyria. Blood. 117: 5494-502. PMID 21310927 DOI: 10.1182/blood-2010-11-319483  0.96
2011 Amigo JD, Yu M, Troadec MB, Gwynn B, Cooney JD, Lambert AJ, Chi NC, Weiss MJ, Peters LL, Kaplan J, Cantor AB, Paw BH. Identification of distal cis-regulatory elements at mouse mitoferrin loci using zebrafish transgenesis. Molecular and Cellular Biology. 31: 1344-56. PMID 21248200 DOI: 10.1128/MCB.01010-10  0.96
2011 Kaplan J, Ward DM, De Domenico I. The molecular basis of iron overload disorders and iron-linked anemias. International Journal of Hematology. 93: 14-20. PMID 21210258 DOI: 10.1007/s12185-010-0760-0  0.96
2011 De Domenico I, Vaughn MB, Paradkar PN, Lo E, Ward DM, Kaplan J. Decoupling ferritin synthesis from free cytosolic iron results in ferritin secretion. Cell Metabolism. 13: 57-67. PMID 21195349 DOI: 10.1016/j.cmet.2010.12.003  0.96
2011 Lin H, Li L, Jia X, Ward DM, Kaplan J. Genetic and biochemical analysis of high iron toxicity in yeast: iron toxicity is due to the accumulation of cytosolic iron and occurs under both aerobic and anaerobic conditions. The Journal of Biological Chemistry. 286: 3851-62. PMID 21115478 DOI: 10.1074/jbc.M110.190959  0.96
2010 Troadec MB, Ward DM, Lo E, Kaplan J, De Domenico I. Induction of FPN1 transcription by MTF-1 reveals a role for ferroportin in transition metal efflux. Blood. 116: 4657-64. PMID 20688958 DOI: 10.1182/blood-2010-04-278614  0.96
2010 De Domenico I, Zhang TY, Koening CL, Branch RW, London N, Lo E, Daynes RA, Kushner JP, Li D, Ward DM, Kaplan J. Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice. The Journal of Clinical Investigation. 120: 2395-405. PMID 20530874 DOI: 10.1172/JCI42011  0.96
2010 Li L, Murdock G, Bagley D, Jia X, Ward DM, Kaplan J. Genetic dissection of a mitochondria-vacuole signaling pathway in yeast reveals a link between chronic oxidative stress and vacuolar iron transport. The Journal of Biological Chemistry. 285: 10232-42. PMID 20139087 DOI: 10.1074/jbc.M109.096859  0.96
2010 De Domenico I, Lo E, Ward DM, Kaplan J. Human mutation D157G in ferroportin leads to hepcidin-independent binding of Jak2 and ferroportin down-regulation. Blood. 115: 2956-9. PMID 20124516 DOI: 10.1182/blood-2009-10-251306  0.96
2010 De Domenico I, Ward DM, Kaplan J. Autophagy, ferritin and iron chelation. Autophagy. 6: 157. PMID 20009528 DOI: 10.4161/auto.6.1.10587  0.96
2009 Takahashi-Makise N, Ward DM, Kaplan J. On the mechanism of iron sensing by IRP2: new players, new paradigms. Nature Chemical Biology. 5: 874-875. PMID 26190951 DOI: 10.1038/nchembio.261  0.96
2009 Koening CL, Mu HH, Van Schelt A, Lo E, Ward DM, Kaplan J, De Domenico I. Hepcidin is elevated in mice injected with Mycoplasma arthritidis. Journal of Inflammation (London, England). 6: 33. PMID 19930711 DOI: 10.1186/1476-9255-6-33  0.96
2009 Morrissey J, Baxter IR, Lee J, Li L, Lahner B, Grotz N, Kaplan J, Salt DE, Guerinot ML. The ferroportin metal efflux proteins function in iron and cobalt homeostasis in Arabidopsis. The Plant Cell. 21: 3326-38. PMID 19861554 DOI: 10.1105/tpc.109.069401  0.96
2009 De Domenico I, Kaplan J. A new wrinkle in the fold: hepcidin links inflammation to the unfolded protein response. Cell Metabolism. 10: 245-6. PMID 19808016 DOI: 10.1016/j.cmet.2009.09.005  0.96
2009 Chen W, Paradkar PN, Li L, Pierce EL, Langer NB, Takahashi-Makise N, Hyde BB, Shirihai OS, Ward DM, Kaplan J, Paw BH. Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. Proceedings of the National Academy of Sciences of the United States of America. 106: 16263-8. PMID 19805291 DOI: 10.1073/pnas.0904519106  0.96
2009 Kaplan CD, Kaplan J. Iron acquisition and transcriptional regulation. Chemical Reviews. 109: 4536-52. PMID 19705827 DOI: 10.1021/cr9001676  0.96
2009 De Domenico I, Ward DM, Kaplan J. Specific iron chelators determine the route of ferritin degradation. Blood. 114: 4546-51. PMID 19671920 DOI: 10.1182/blood-2009-05-224188  0.96
2009 Nilsson R, Schultz IJ, Pierce EL, Soltis KA, Naranuntarat A, Ward DM, Baughman JM, Paradkar PN, Kingsley PD, Culotta VC, Kaplan J, Palis J, Paw BH, Mootha VK. Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis. Cell Metabolism. 10: 119-30. PMID 19656490 DOI: 10.1016/j.cmet.2009.06.012  0.96
2009 Koening CL, Miller JC, Nelson JM, Ward DM, Kushner JP, Bockenstedt LK, Weis JJ, Kaplan J, De Domenico I. Toll-like receptors mediate induction of hepcidin in mice infected with Borrelia burgdorferi. Blood. 114: 1913-8. PMID 19587376 DOI: 10.1182/blood-2009-03-209577  0.96
2009 Lin H, Burton D, Li L, Warner DE, Phillips JD, Ward DM, Kaplan J. Gain-of-function mutations identify amino acids within transmembrane domains of the yeast vacuolar transporter Zrc1 that determine metal specificity. The Biochemical Journal. 422: 273-83. PMID 19538181 DOI: 10.1042/BJ20090853  0.96
2009 Fernandes A, Preza GC, Phung Y, De Domenico I, Kaplan J, Ganz T, Nemeth E. The molecular basis of hepcidin-resistant hereditary hemochromatosis. Blood. 114: 437-43. PMID 19383972 DOI: 10.1182/blood-2008-03-146134  0.96
2009 De Domenico I, Lo E, Ward DM, Kaplan J. Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2. Proceedings of the National Academy of Sciences of the United States of America. 106: 3800-5. PMID 19234114 DOI: 10.1073/pnas.0900453106  0.96
2009 De Domenico I, Ward DM, Kaplan J. Serum ferritin regulates blood vessel formation: a role beyond iron storage. Proceedings of the National Academy of Sciences of the United States of America. 106: 1683-4. PMID 19193849 DOI: 10.1073/pnas.0813318106  0.96
2009 Troadec MB, Ward DM, Kaplan J. A Tf-independent iron transport system required for organogenesis. Developmental Cell. 16: 3-4. PMID 19154711 DOI: 10.1016/j.devcel.2008.12.013  0.96
2009 Paradkar PN, Zumbrennen KB, Paw BH, Ward DM, Kaplan J. Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2. Molecular and Cellular Biology. 29: 1007-16. PMID 19075006 DOI: 10.1128/MCB.01685-08  0.96
2008 Silvestri L, Pagani A, Nai A, De Domenico I, Kaplan J, Camaschella C. The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin. Cell Metabolism. 8: 502-11. PMID 18976966 DOI: 10.1016/j.cmet.2008.09.012  0.96
2008 Lin H, Kumánovics A, Nelson JM, Warner DE, Ward DM, Kaplan J. A single amino acid change in the yeast vacuolar metal transporters ZRC1 and COT1 alters their substrate specificity. The Journal of Biological Chemistry. 283: 33865-73. PMID 18930916 DOI: 10.1074/jbc.M804377200  0.96
2008 Wilson J, Huynh C, Kennedy KA, Ward DM, Kaplan J, Aderem A, Andrews NW. Control of parasitophorous vacuole expansion by LYST/Beige restricts the intracellular growth of Leishmania amazonensis. Plos Pathogens. 4: e1000179. PMID 18927622 DOI: 10.1371/journal.ppat.1000179  0.96
2008 Girelli D, De Domenico I, Bozzini C, Campostrini N, Busti F, Castagna A, Soriani N, Cremonesi L, Ferrari M, Colombari R, McVey Ward D, Kaplan J, Corrocher R. Clinical, pathological, and molecular correlates in ferroportin disease: a study of two novel mutations. Journal of Hepatology. 49: 664-71. PMID 18713659 DOI: 10.1016/j.jhep.2008.05.028  0.96
2008 De Domenico I, Nemeth E, Nelson JM, Phillips JD, Ajioka RS, Kay MS, Kushner JP, Ganz T, Ward DM, Kaplan J. The hepcidin-binding site on ferroportin is evolutionarily conserved. Cell Metabolism. 8: 146-56. PMID 18680715 DOI: 10.1016/j.cmet.2008.07.002  0.96
2008 Kieffer C, Skalicky JJ, Morita E, De Domenico I, Ward DM, Kaplan J, Sundquist WI. Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding. Developmental Cell. 15: 62-73. PMID 18606141 DOI: 10.1016/j.devcel.2008.05.014  0.96
2008 Paradkar PN, De Domenico I, Durchfort N, Zohn I, Kaplan J, Ward DM. Iron depletion limits intracellular bacterial growth in macrophages. Blood. 112: 866-74. PMID 18369153 DOI: 10.1182/blood-2007-12-126854  0.96
2008 Troadec MB, Kaplan J. Some vertebrates go with the GLO. Cell. 132: 921-2. PMID 18358804 DOI: 10.1016/j.cell.2008.03.005  0.96
2008 Kumánovics A, Chen OS, Li L, Bagley D, Adkins EM, Lin H, Dingra NN, Outten CE, Keller G, Winge D, Ward DM, Kaplan J. Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis. The Journal of Biological Chemistry. 283: 10276-86. PMID 18281282 DOI: 10.1074/jbc.M801160200  0.96
2008 Keel SB, Doty RT, Yang Z, Quigley JG, Chen J, Knoblaugh S, Kingsley PD, De Domenico I, Vaughn MB, Kaplan J, Palis J, Abkowitz JL. A heme export protein is required for red blood cell differentiation and iron homeostasis. Science (New York, N.Y.). 319: 825-8. PMID 18258918 DOI: 10.1126/science.1151133  0.96
2008 Li L, Bagley D, Ward DM, Kaplan J. Yap5 is an iron-responsive transcriptional activator that regulates vacuolar iron storage in yeast. Molecular and Cellular Biology. 28: 1326-37. PMID 18070921 DOI: 10.1128/MCB.01219-07  0.96
2008 Kaplan J, De Domenico I, Ward DM. Chediak-Higashi syndrome. Current Opinion in Hematology. 15: 22-9. PMID 18043242 DOI: 10.1097/MOH.0b013e3282f2bcce  0.96
2008 De Domenico I, McVey Ward D, Kaplan J. Regulation of iron acquisition and storage: consequences for iron-linked disorders. Nature Reviews. Molecular Cell Biology. 9: 72-81. PMID 17987043 DOI: 10.1038/nrm2295  0.96
2008 Askwith C, Kaplan J. The biochemistry and molecular biology of iron metabolism in yeast Iron Metabolism: Inorganic Biochemistry and Regulatory Mechanisms. 51-63. DOI: 10.1002/9783527613700.ch04  0.96
2007 De Domenico I, Vaughn MB, Yoon D, Kushner JP, Ward DM, Kaplan J. Zebrafish as a model for defining the functional impact of mammalian ferroportin mutations. Blood. 110: 3780-3. PMID 17726163 DOI: 10.1182/blood-2007-07-100248  0.96
2007 Wang F, Paradkar PN, Custodio AO, McVey Ward D, Fleming MD, Campagna D, Roberts KA, Boyartchuk V, Dietrich WF, Kaplan J, Andrews NC. Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice. Nature Genetics. 39: 1025-32. PMID 17632513 DOI: 10.1038/ng2059  0.96
2007 De Domenico I, Ward DM, Kaplan J. Hepcidin regulation: ironing out the details. The Journal of Clinical Investigation. 117: 1755-8. PMID 17607352 DOI: 10.1172/JCI32701  0.96
2007 De Domenico I, Ward DM, di Patti MC, Jeong SY, David S, Musci G, Kaplan J. Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin. The Embo Journal. 26: 2823-31. PMID 17541408 DOI: 10.1038/sj.emboj.7601735  0.96
2007 Möhlig H, Mathieu S, Thon L, Frederiksen MC, Ward DM, Kaplan J, Schütze S, Kabelitz D, Adam D. The WD repeat protein FAN regulates lysosome size independent from abnormal downregulation/membrane recruitment of protein kinase C. Experimental Cell Research. 313: 2703-18. PMID 17512928 DOI: 10.1016/j.yexcr.2007.04.020  0.96
2007 De Domenico I, Ward DM, Langelier C, Vaughn MB, Nemeth E, Sundquist WI, Ganz T, Musci G, Kaplan J. The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Molecular Biology of the Cell. 18: 2569-78. PMID 17475779 DOI: 10.1091/mbc.E07-01-0060  0.96
2007 Zohn IE, De Domenico I, Pollock A, Ward DM, Goodman JF, Liang X, Sanchez AJ, Niswander L, Kaplan J. The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease. Blood. 109: 4174-80. PMID 17289807 DOI: 10.1182/blood-2007-01-066068  0.96
2007 De Domenico I, Ward DM, Musci G, Kaplan J. Evidence for the multimeric structure of ferroportin. Blood. 109: 2205-9. PMID 17077321 DOI: 10.1182/blood-2006-06-032516  0.96
2006 De Domenico I, Vaughn MB, Li L, Bagley D, Musci G, Ward DM, Kaplan J. Ferroportin-mediated mobilization of ferritin iron precedes ferritin degradation by the proteasome. The Embo Journal. 25: 5396-404. PMID 17082767 DOI: 10.1038/sj.emboj.7601409  0.96
2006 Kim SA, Punshon T, Lanzirotti A, Li L, Alonso JM, Ecker JR, Kaplan J, Guerinot ML. Localization of iron in Arabidopsis seed requires the vacuolar membrane transporter VIT1. Science (New York, N.Y.). 314: 1295-8. PMID 17082420 DOI: 10.1126/science.1132563  0.96
2006 Langelier C, von Schwedler UK, Fisher RD, De Domenico I, White PL, Hill CP, Kaplan J, Ward D, Sundquist WI. Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release. Journal of Virology. 80: 9465-80. PMID 16973552 DOI: 10.1128/JVI.01049-06  0.96
2006 Davis-Kaplan SR, Compton MA, Flannery AR, Ward DM, Kaplan J, Stevens TH, Graham LA. PKR1 encodes an assembly factor for the yeast V-type ATPase. The Journal of Biological Chemistry. 281: 32025-35. PMID 16926153 DOI: 10.1074/jbc.M606451200  0.96
2006 De Domenico I, McVey Ward D, Nemeth E, Ganz T, Corradini E, Ferrara F, Musci G, Pietrangelo A, Kaplan J. Molecular and clinical correlates in iron overload associated with mutations in ferroportin. Haematologica. 91: 1092-5. PMID 16885049  0.96
2006 Kumánovics A, Poruk KE, Osborn KA, Ward DM, Kaplan J. YKE4 (YIL023C) encodes a bidirectional zinc transporter in the endoplasmic reticulum of Saccharomyces cerevisiae. The Journal of Biological Chemistry. 281: 22566-74. PMID 16760462 DOI: 10.1074/jbc.M604730200  0.96
2006 Kaplan J, McVey Ward D, Crisp RJ, Philpott CC. Iron-dependent metabolic remodeling in S. cerevisiae. Biochimica Et Biophysica Acta. 1763: 646-51. PMID 16697062 DOI: 10.1016/j.bbamcr.2006.03.008  0.96
2006 Runkel F, Büssow H, Seburn KL, Cox GA, Ward DM, Kaplan J, Franz T. Grey, a novel mutation in the murine Lyst gene, causes the beige phenotype by skipping of exon 25. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 17: 203-10. PMID 16518687 DOI: 10.1007/s00335-005-0015-1  0.96
2006 Shaw GC, Cope JJ, Li L, Corson K, Hersey C, Ackermann GE, Gwynn B, Lambert AJ, Wingert RA, Traver D, Trede NS, Barut BA, Zhou Y, Minet E, Donovan A, ... ... Kaplan J, et al. Mitoferrin is essential for erythroid iron assimilation. Nature. 440: 96-100. PMID 16511496 DOI: 10.1038/nature04512  0.96
2006 Crisp RJ, Adkins EM, Kimmel E, Kaplan J. Recruitment of Tup1p and Cti6p regulates heme-deficient expression of Aft1p target genes. The Embo Journal. 25: 512-21. PMID 16437160 DOI: 10.1038/sj.emboj.7600961  0.96
2006 De Domenico I, Ward DM, Musci G, Kaplan J. Iron overload due to mutations in ferroportin. Haematologica. 91: 92-5. PMID 16434376  0.96
2006 Nemeth E, Preza GC, Jung CL, Kaplan J, Waring AJ, Ganz T. The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study. Blood. 107: 328-33. PMID 16141345 DOI: 10.1182/blood-2005-05-2049  0.96
2005 Wingert RA, Galloway JL, Barut B, Foott H, Fraenkel P, Axe JL, Weber GJ, Dooley K, Davidson AJ, Schmid B, Schmidt B, Paw BH, Shaw GC, Kingsley P, Palis J, ... ... Kaplan J, et al. Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis. Nature. 436: 1035-39. PMID 16110529 DOI: 10.1038/nature03887  0.96
2005 Kaplan CD, Kaplan J. Regulatory oversight of the iron trade: posttranscriptional regulation in yeast. Cell Metabolism. 2: 4-6. PMID 16054093 DOI: 10.1016/j.cmet.2005.06.008  0.96
2005 De Domenico I, Ward DM, Nemeth E, Vaughn MB, Musci G, Ganz T, Kaplan J. The molecular basis of ferroportin-linked hemochromatosis. Proceedings of the National Academy of Sciences of the United States of America. 102: 8955-60. PMID 15956209 DOI: 10.1073/pnas.0503804102  0.96
2005 Felice MR, De Domenico I, Li L, Ward DM, Bartok B, Musci G, Kaplan J. Post-transcriptional regulation of the yeast high affinity iron transport system. The Journal of Biological Chemistry. 280: 22181-90. PMID 15817488 DOI: 10.1074/jbc.M414663200  0.96
2005 Ward DM, Vaughn MB, Shiflett SL, White PL, Pollock AL, Hill J, Schnegelberger R, Sundquist WI, Kaplan J. The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells. The Journal of Biological Chemistry. 280: 10548-55. PMID 15644320 DOI: 10.1074/jbc.M413734200  0.96
2004 Huynh C, Roth D, Ward DM, Kaplan J, Andrews NW. Defective lysosomal exocytosis and plasma membrane repair in Chediak-Higashi/beige cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 16795-800. PMID 15557559 DOI: 10.1073/pnas.0405905101  0.96
2004 Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science (New York, N.Y.). 306: 2090-3. PMID 15514116 DOI: 10.1126/science.1104742  0.96
2004 Shiflett SL, Vaughn MB, Huynh D, Kaplan J, Ward DM. Bph1p, the Saccharomyces cerevisiae homologue of CHS1/beige, functions in cell wall formation and protein sorting. Traffic (Copenhagen, Denmark). 5: 700-10. PMID 15296494 DOI: 10.1111/j.1600-0854.2004.00213.x  0.96
2004 Li L, Kaplan J. A mitochondrial-vacuolar signaling pathway in yeast that affects iron and copper metabolism. The Journal of Biological Chemistry. 279: 33653-61. PMID 15161905 DOI: 10.1074/jbc.M403146200  0.96
2004 Chen OS, Crisp RJ, Valachovic M, Bard M, Winge DR, Kaplan J. Transcription of the yeast iron regulon does not respond directly to iron but rather to iron-sulfur cluster biosynthesis. The Journal of Biological Chemistry. 279: 29513-8. PMID 15123701 DOI: 10.1074/jbc.M403209200  0.96
2004 Harris ZL, Davis-Kaplan SR, Gitlin JD, Kaplan J. A fungal multicopper oxidase restores iron homeostasis in aceruloplasminemia. Blood. 103: 4672-3. PMID 14739215 DOI: 10.1182/blood-2003-11-4060  0.96
2004 Shiflett SL, Ward DM, Huynh D, Vaughn MB, Simmons JC, Kaplan J. Characterization of Vta1p, a class E Vps protein in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 279: 10982-90. PMID 14701806 DOI: 10.1074/jbc.M312669200  0.96
2004 Davis-Kaplan SR, Ward DM, Shiflett SL, Kaplan J. Genome-wide analysis of iron-dependent growth reveals a novel yeast gene required for vacuolar acidification. The Journal of Biological Chemistry. 279: 4322-9. PMID 14594803 DOI: 10.1074/jbc.M310680200  0.96
2003 von Schwedler UK, Stuchell M, Müller B, Ward DM, Chung HY, Morita E, Wang HE, Davis T, He GP, Cimbora DM, Scott A, Kräusslich HG, Kaplan J, Morham SG, Sundquist WI. The protein network of HIV budding. Cell. 114: 701-13. PMID 14505570 DOI: 10.1016/S0092-8674(03)00714-1  0.96
2003 Ward DM, Shiflett SL, Huynh D, Vaughn MB, Prestwich G, Kaplan J. Use of expression constructs to dissect the functional domains of the CHS/beige protein: identification of multiple phenotypes. Traffic (Copenhagen, Denmark). 4: 403-15. PMID 12753649 DOI: 10.1034/j.1600-0854.2003.00093.x  0.96
2003 Tuttle MS, Radisky D, Li L, Kaplan J. A dominant allele of PDR1 alters transition metal resistance in yeast. The Journal of Biological Chemistry. 278: 1273-80. PMID 12411429 DOI: 10.1074/jbc.M209631200  0.48
2002 Kaplan J. Strategy and tactics in the evolution of iron acquisition. Seminars in Hematology. 39: 219-26. PMID 12382196 DOI: 10.1053/shem.2002.35631  0.96
2002 Van Ho A, Ward DM, Kaplan J. Transition metal transport in yeast. Annual Review of Microbiology. 56: 237-61. PMID 12142483 DOI: 10.1146/annurev.micro.56.012302.160847  0.96
2002 Ward DM, Shiflett SL, Kaplan J. Chediak-Higashi syndrome: a clinical and molecular view of a rare lysosomal storage disorder. Current Molecular Medicine. 2: 469-77. PMID 12125812 DOI: 10.2174/1566524023362339  0.96
2002 Shiflett SL, Kaplan J, Ward DM. Chediak-Higashi Syndrome: a rare disorder of lysosomes and lysosome related organelles. Pigment Cell Research / Sponsored by the European Society For Pigment Cell Research and the International Pigment Cell Society. 15: 251-7. PMID 12100490 DOI: 10.1034/j.1600-0749.2002.02038.x  0.96
1998 Davis-Kaplan SR, Askwith CC, Bengtzen AC, Radisky D, Kaplan J. Chloride is an allosteric effector of copper assembly for the yeast multicopper oxidase Fet3p: an unexpected role for intracellular chloride channels. Proceedings of the National Academy of Sciences of the United States of America. 95: 13641-5. PMID 9811853 DOI: 10.1073/pnas.95.23.13641  0.96
1998 Askwith CC, Kaplan J. Site-directed mutagenesis of the yeast multicopper oxidase Fet3p. The Journal of Biological Chemistry. 273: 22415-9. PMID 9712864 DOI: 10.1074/jbc.273.35.22415  0.96
1996 Askwith CC, de Silva D, Kaplan J. Molecular biology of iron acquisition in Saccharomyces cerevisiae. Molecular Microbiology. 20: 27-34. PMID 8861201 DOI: 10.1111/j.1365-2958.1996.tb02485.x  0.96
1996 de Silva DM, Askwith CC, Kaplan J. Molecular mechanisms of iron uptake in eukaryotes. Physiological Reviews. 76: 31-47. PMID 8592731  0.96
1995 De Silva DM, Askwith CC, Eide D, Kaplan J. The FET3 gene product required for high affinity iron transport in yeast is a cell surface ferroxidase. The Journal of Biological Chemistry. 270: 1098-101. PMID 7836366 DOI: 10.1074/jbc.270.3.1098  0.96
1975 Kaplan J, Moskowitz M. Studies on the turnover of plasma membranes in cultured mammalian cells. II. Demonstration of heterogeneous rates of turnover for plasma membrane proteins and glycoproteins. Biochimica Et Biophysica Acta. 389: 306-13. PMID 1169981 DOI: 10.1016/0005-2736(75)90323-5  0.96
1975 Kaplan J, Moskowitz M. Studies on the turnover of plasma membranes in cultured mammalina cells. I. Rates of synthesis and degradation of plasma membrane proteins and carbohydrates. Biochimica Et Biophysica Acta. 389: 290-305. PMID 1169980  1
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