Harm Kampinga - Publications

Biomedical Sciences of Cells & Systems University Medical Center Groningen and University of Groningen, Groningen, Groningen, Netherlands 

54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ryder BD, Boyer DR, Ustyantseva E, Mendoza-Oliva A, Kuska MI, Wydorski PM, Sawaya M, Diamond MI, Eisenberg DS, Kampinga HH, Joachimiak LA. DNAJB8 oligomerization is mediated by an aromatic-rich motif that is dispensable for substrate activity. Biorxiv : the Preprint Server For Biology. PMID 36945632 DOI: 10.1101/2023.03.06.531355  0.351
2022 Kuiper EFE, Gallardo P, Bergsma T, Mari M, Kolbe Musskopf M, Kuipers J, Giepmans BNG, Steen A, Kampinga HH, Veenhoff LM, Bergink S. The chaperone DNAJB6 surveils FG-nucleoporins and is required for interphase nuclear pore complex biogenesis. Nature Cell Biology. 24: 1584-1594. PMID 36302971 DOI: 10.1038/s41556-022-01010-x  0.403
2022 Mauthe M, Kampinga HH, Hipp MS, Reggiori F. Digest it all: the lysosomal turnover of cytoplasmic aggregates. Trends in Biochemical Sciences. PMID 36280494 DOI: 10.1016/j.tibs.2022.09.012  0.539
2022 Huiting W, Dekker SL, van der Lienden JCJ, Mergener R, Musskopf MK, Furtado GV, Gerrits E, Coit D, Oghbaie M, Di Stefano LH, Schepers H, van Waarde-Verhagen MAWH, Couzijn S, Barazzuol L, LaCava J, ... Kampinga HH, et al. Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome. Elife. 11. PMID 35200138 DOI: 10.7554/eLife.70726  0.531
2021 Joshi BS, Youssef SA, Bron R, de Bruin A, Kampinga HH, Zuhorn IS. DNAJB6b-enriched small extracellular vesicles decrease polyglutamine aggregation in and models of Huntington disease. Iscience. 24: 103282. PMID 34755099 DOI: 10.1016/j.isci.2021.103282  0.422
2021 Furtado GV, Yang J, Wu D, Papagiannopoulos CI, Terpstra HM, Kuiper EFE, Krauss S, Zhu WG, Kampinga HH, Bergink S. FOXO1 controls protein synthesis and transcript abundance of mutant polyglutamine proteins, preventing protein aggregation. Human Molecular Genetics. PMID 33822053 DOI: 10.1093/hmg/ddab095  0.53
2021 McMahon S, Bergink S, Kampinga HH, Ecroyd H. DNAJB chaperones suppress destabilised protein aggregation via a region unique from that used to inhibit amyloidogenesis. Journal of Cell Science. PMID 33674449 DOI: 10.1242/jcs.255596  0.562
2020 Leotti VB, de Vries JJ, Oliveira CM, de Mattos EP, Te Meerman GJ, Brunt ER, Kampinga HH, Jardim LB, Verbeek DS. CAG Repeat Size Influences the Progression Rate of Spinocerebellar Ataxia Type 3. Annals of Neurology. PMID 32978817 DOI: 10.1002/ana.25919  0.325
2020 Nachman E, Wentink AS, Madiona K, Bousset L, Katsinelos T, Allinson K, Kampinga H, McEwan WA, Jahn TR, Melki R, Mogk A, Bukau B, Nussbaum-Krammer C. Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species. The Journal of Biological Chemistry. PMID 32467226 DOI: 10.1074/Jbc.Ra120.013478  0.378
2020 Serlidaki D, van Waarde MAWH, Rohland L, Wentink AS, Dekker SL, Kamphuis MJ, Boertien JM, Brunsting JF, Nillegoda NB, Bukau B, Mayer MP, Kampinga HH, Bergink S. Functional diversity between HSP70 paralogs due to variable interactions with specific co-chaperones. The Journal of Biological Chemistry. PMID 32284329 DOI: 10.1074/Jbc.Ra119.012449  0.417
2020 Thiruvalluvan A, de Mattos EP, Brunsting JF, Bakels R, Serlidaki D, Barazzuol L, Conforti P, Fatima A, Koyuncu S, Cattaneo E, Vilchez D, Bergink S, Boddeke EHWG, Copray S, Kampinga HH. DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis. Molecular Cell. PMID 32268123 DOI: 10.1016/J.Molcel.2020.02.022  0.431
2020 De Mattos EP, Wentink A, Nussbaum-Krammer C, Hansen C, Bergink S, Melki R, Kampinga HH. Protein Quality Control Pathways at the Crossroad of Synucleinopathies. Journal of Parkinson's Disease. PMID 31985474 DOI: 10.3233/JPD-191790  0.439
2019 Kampinga HH, Mayer MP, Mogk A. Protein quality control: from mechanism to disease : EMBO Workshop, Costa de la Calma (Mallorca), Spain, April 28 - May 03, 2019. Cell Stress & Chaperones. PMID 31713048 DOI: 10.1007/s12192-019-01040-9  0.483
2019 Azkanaz M, Rodríguez López A, de Boer B, Huiting W, Angrand PO, Vellenga E, Kampinga HH, Bergink S, Martens JH, Schuringa JJ, van den Boom V. Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock. Elife. 8. PMID 31199242 DOI: 10.7554/eLife.45205  0.348
2019 Wu D, Vonk JJ, Salles F, Vonk D, Haslbeck M, Melki R, Bergink S, Kampinga HH. The N terminus of the small heat shock protein HSPB7 drives its polyQ aggregation-suppressing activity. The Journal of Biological Chemistry. PMID 31097540 DOI: 10.1074/jbc.RA118.007117  0.471
2018 Meister-Broekema M, Freilich R, Jagadeesan C, Rauch JN, Bengoechea R, Motley WW, Kuiper EFE, Minoia M, Furtado GV, van Waarde MAWH, Bird SJ, Rebelo A, Zuchner S, Pytel P, Scherer SS, ... ... Kampinga HH, et al. Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks. Nature Communications. 9: 5342. PMID 30559338 DOI: 10.1038/S41467-018-07718-5  0.425
2018 Kampinga HH, Andreasson C, Barducci A, Cheetham ME, Cyr D, Emanuelsson C, Genevaux P, Gestwicki JE, Goloubinoff P, Huerta-Cepas J, Kirstein J, Liberek K, Mayer MP, Nagata K, Nillegoda NB, et al. Function, evolution, and structure of J-domain proteins. Cell Stress & Chaperones. PMID 30478692 DOI: 10.1007/S12192-018-0948-4  0.309
2018 Bason M, Meister-Broekema M, Alberts N, Dijkers P, Bergink S, Sibon OCM, Kampinga HH. Astrocytic expression of the chaperone DNAJB6 results in non-cell autonomous protection in Huntington's disease. Neurobiology of Disease. 124: 108-117. PMID 30408590 DOI: 10.1016/j.nbd.2018.10.017  0.472
2018 Ast A, Buntru A, Schindler F, Hasenkopf R, Schulz A, Brusendorf L, Klockmeier K, Grelle G, McMahon B, Niederlechner H, Jansen I, Diez L, Edel J, Boeddrich A, Franklin SA, ... ... Kampinga HH, et al. mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington's Disease. Molecular Cell. 71: 675-688.e6. PMID 30193095 DOI: 10.1016/J.Molcel.2018.07.032  0.362
2018 Mogk A, Bukau B, Kampinga HH. Cellular Handling of Protein Aggregates by Disaggregation Machines. Molecular Cell. 69: 214-226. PMID 29351843 DOI: 10.1016/J.Molcel.2018.01.004  0.56
2018 van Waarde-Verhagen MAWH, Kampinga HH. Measurement of Chaperone-Mediated Effects on Polyglutamine Protein Aggregation by the Filter Trap Assay. Methods in Molecular Biology (Clifton, N.J.). 1709: 59-74. PMID 29177651 DOI: 10.1007/978-1-4939-7477-1_5  0.565
2017 Carra S, Alberti S, Arrigo PA, Benesch JL, Benjamin IJ, Boelens W, Bartelt-Kirbach B, Brundel BJ, Buchner J, Bukau B, Carver JA, Ecroyd H, Emanuelsson C, Finet S, Golenhofen N, ... ... Kampinga HH, et al. The growing world of small heat shock proteins: from structure to functions. Cell Stress & Chaperones. PMID 28364346 DOI: 10.1007/S12192-017-0787-8  0.514
2016 Kakkar V, Kuiper EF, Pandey A, Braakman I, Kampinga HH. Versatile members of the DNAJ family show Hsp70 dependent anti-aggregation activity on RING1 mutant parkin C289G. Scientific Reports. 6: 34830. PMID 27713507 DOI: 10.1038/Srep34830  0.549
2016 Kakkar V, Månsson C, de Mattos EP, Bergink S, van der Zwaag M, van Waarde MA, Kloosterhuis NJ, Melki R, van Cruchten RT, Al-Karadaghi S, Arosio P, Dobson CM, Knowles TP, Bates GP, van Deursen JM, ... ... Kampinga HH, et al. The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model. Molecular Cell. PMID 27151442 DOI: 10.1016/J.Molcel.2016.03.017  0.498
2016 Kampinga HH, Bergink S. Heat shock proteins as potential targets for protective strategies in neurodegeneration. The Lancet. Neurology. 15: 748-759. PMID 27106072 DOI: 10.1016/S1474-4422(16)00099-5  0.638
2016 Eenjes E, Dragich JM, Kampinga HH, Yamamoto A. Distinguishing aggregate formation and aggregate clearance using cell based assays. Journal of Cell Science. PMID 26818841 DOI: 10.1242/Jcs.179978  0.539
2015 Vos MJ, Carra S, Kanon B, Bosveld F, Klauke K, Sibon OC, Kampinga HH. Specific protein homeostatic functions of small heat-shock proteins increase lifespan. Aging Cell. 15: 217-26. PMID 26705243 DOI: 10.1111/acel.12422  0.507
2015 Snijder PM, Baratashvili M, Grzeschik NA, Leuvenink HG, Kuijpers L, Huitema S, Schaap O, Giepmans BN, Kuipers J, Miljkovic JL, Mitrovic A, Bos EM, Szabó C, Kampinga HH, Dijkers PF, et al. Overexpression of cystathionine γ-lyase suppresses detrimental effects of spinocerebellar ataxia type 3. Molecular Medicine (Cambridge, Mass.). PMID 26467707 DOI: 10.2119/Molmed.2015.00221  0.435
2015 Dekker SL, Kampinga HH, Bergink S. DNAJs: more than substrate delivery to HSPA. Frontiers in Molecular Biosciences. 2: 35. PMID 26176011 DOI: 10.3389/fmolb.2015.00035  0.439
2015 Hussein RM, Benjamin IJ, Kampinga HH. Rescue of αB Crystallin (HSPB5) Mutants Associated Protein Aggregation by Co-Expression of HSPB5 Partners. Plos One. 10: e0126761. PMID 25961584 DOI: 10.1371/journal.pone.0126761  0.364
2014 Ma?nsson C, Arosio P, Hussein R, Kampinga HH, Hashem RM, Boelens WC, Dobson CM, Knowles TPJ, Linse S, Emanuelsson C. Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation Journal of Biological Chemistry. 289: 31066-31076. PMID 25217638 DOI: 10.1074/Jbc.M114.595124  0.434
2014 Minoia M, Grit C, Kampinga HH. HSPA1A-independent suppression of PARK2 C289G protein aggregation by human small heat shock proteins. Molecular and Cellular Biology. 34: 3570-8. PMID 25022755 DOI: 10.1128/MCB.00698-14  0.536
2014 Kakkar V, Meister-Broekema M, Minoia M, Carra S, Kampinga HH. Barcoding heat shock proteins to human diseases: looking beyond the heat shock response. Disease Models & Mechanisms. 7: 421-34. PMID 24719117 DOI: 10.1242/dmm.014563  0.544
2014 Vonk WI, Kakkar V, Bartuzi P, Jaarsma D, Berger R, Hofker MH, Klomp LW, Wijmenga C, Kampinga HH, van de Sluis B. The Copper Metabolism MURR1 domain protein 1 (COMMD1) modulates the aggregation of misfolded protein species in a client-specific manner. Plos One. 9: e92408. PMID 24691167 DOI: 10.1371/Journal.Pone.0092408  0.564
2014 MÃ¥nsson C, Kakkar V, Monsellier E, Sourigues Y, Härmark J, Kampinga HH, Melki R, Emanuelsson C. DNAJB6 is a peptide-binding chaperone which can suppress amyloid fibrillation of polyglutamine peptides at substoichiometric molar ratios. Cell Stress & Chaperones. 19: 227-39. PMID 23904097 DOI: 10.1007/S12192-013-0448-5  0.411
2013 Yang J, Carra S, Zhu WG, Kampinga HH. The regulation of the autophagic network and its implications for human disease. International Journal of Biological Sciences. 9: 1121-33. PMID 24339733 DOI: 10.7150/ijbs.6666  0.315
2013 Gillis J, Schipper-Krom S, Juenemann K, Gruber A, Coolen S, Van Den Nieuwendijk R, Van Veen H, Overkleeft H, Goedhart J, Kampinga HH, Reits EA. The DNAJB6 and DNAJB8 protein chaperones prevent intracellular aggregation of polyglutamine peptides Journal of Biological Chemistry. 288: 17225-17237. PMID 23612975 DOI: 10.1074/Jbc.M112.421685  0.463
2013 Carra S, Rusmini P, Crippa V, Giorgetti E, Boncoraglio A, Cristofani R, Naujock M, Meister M, Minoia M, Kampinga HH, Poletti A. Different anti-aggregation and pro-degradative functions of the members of the mammalian sHSP family in neurological disorders. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 368: 20110409. PMID 23530259 DOI: 10.1098/rstb.2011.0409  0.551
2013 Kakkar V, Prins LC, Kampinga HH. DNAJ proteins and protein aggregation diseases. Current Topics in Medicinal Chemistry. 12: 2479-90. PMID 23339302 DOI: 10.2174/1568026611212220004  0.644
2012 Mannini B, Cascella R, Zampagni M, Van Waarde-Verhagen M, Meehan S, Roodveldt C, Campioni S, Boninsegna M, Penco A, Relini A, Kampinga HH, Dobson CM, Wilson MR, Cecchi C, Chiti F. Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers Proceedings of the National Academy of Sciences of the United States of America. 109: 12479-12484. PMID 22802614 DOI: 10.1073/Pnas.1117799109  0.468
2011 Carra S, Crippa V, Rusmini P, Boncoraglio A, Minoia M, Giorgetti E, Kampinga HH, Poletti A. Alteration of protein folding and degradation in motor neuron diseases: Implications and protective functions of small heat shock proteins. Progress in Neurobiology. 97: 83-100. PMID 21971574 DOI: 10.1016/j.pneurobio.2011.09.009  0.431
2011 Hishiya A, Salman MN, Carra S, Kampinga HH, Takayama S. BAG3 directly interacts with mutated alphaB-crystallin to suppress its aggregation and toxicity. Plos One. 6: e16828. PMID 21423662 DOI: 10.1371/journal.pone.0016828  0.306
2011 Hageman J, van Waarde MA, Zylicz A, Walerych D, Kampinga HH. The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities. The Biochemical Journal. 435: 127-42. PMID 21231916 DOI: 10.1042/BJ20101247  0.345
2011 Vos MJ, Zijlstra MP, Carra S, Sibon OC, Kampinga HH. Small heat shock proteins, protein degradation and protein aggregation diseases. Autophagy. 7: 101-3. PMID 21045566 DOI: 10.4161/auto.7.1.13935  0.517
2010 Carra S, Boncoraglio A, Kanon B, Brunsting JF, Minoia M, Rana A, Vos MJ, Seidel K, Sibon OC, Kampinga HH. Identification of the Drosophila ortholog of HSPB8: implication of HSPB8 loss of function in protein folding diseases. The Journal of Biological Chemistry. 285: 37811-22. PMID 20858900 DOI: 10.1074/jbc.M110.127498  0.46
2010 Vos MJ, Zijlstra MP, Kanon B, van Waarde-Verhagen MA, Brunt ER, Oosterveld-Hut HM, Carra S, Sibon OC, Kampinga HH. HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones. Human Molecular Genetics. 19: 4677-93. PMID 20843828 DOI: 10.1093/hmg/ddq398  0.347
2010 Kampinga HH, Craig EA. The HSP70 chaperone machinery: J proteins as drivers of functional specificity. Nature Reviews. Molecular Cell Biology. 11: 579-92. PMID 20651708 DOI: 10.1038/Nrm2941  0.394
2010 Seidel K, den Dunnen WF, Schultz C, Paulson H, Frank S, de Vos RA, Brunt ER, Deller T, Kampinga HH, Rüb U. Axonal inclusions in spinocerebellar ataxia type 3. Acta Neuropathologica. 120: 449-60. PMID 20635090 DOI: 10.1007/S00401-010-0717-7  0.38
2010 Hageman J, Rujano MA, van Waarde MAWH, Kakkar V, Dirks RP, Govorukhina N, Oosterveld-Hut HMJ, Lubsen NH, Kampinga HH. A DNAJB Chaperone Subfamily with HDAC-Dependent Activities Suppresses Toxic Protein Aggregation Molecular Cell. 37: 355-369. PMID 20159555 DOI: 10.1016/j.molcel.2010.01.001  0.546
2009 Carra S, Brunsting JF, Lambert H, Landry J, Kampinga HH. HspB8 participates in protein quality control by a non-chaperone-like mechanism that requires eIF2{alpha} phosphorylation. The Journal of Biological Chemistry. 284: 5523-32. PMID 19114712 DOI: 10.1074/Jbc.M807440200  0.423
2008 Vos MJ, Hageman J, Carra S, Kampinga HH. Structural and functional diversities between members of the human HSPB, HSPH, HSPA, and DNAJ chaperone families. Biochemistry. 47: 7001-11. PMID 18557634 DOI: 10.1021/bi800639z  0.364
2008 Vos MJ, Kampinga HH. A PCR amplification strategy for unrestricted generation of chimeric genes. Analytical Biochemistry. 380: 338-40. PMID 18555003 DOI: 10.1016/j.ab.2008.05.031  0.345
2008 Brundel BJ, Ke L, Dijkhuis AJ, Qi X, Shiroshita-Takeshita A, Nattel S, Henning RH, Kampinga HH. Heat shock proteins as molecular targets for intervention in atrial fibrillation. Cardiovascular Research. 78: 422-8. PMID 18326558 DOI: 10.1093/Cvr/Cvn060  0.331
2007 Rujano MA, Bosveld F, Salomons FA, Dijk F, van Waarde MA, van der Want JJ, de Vos RA, Brunt ER, Sibon OC, Kampinga HH. Polarised asymmetric inheritance of accumulated protein damage in higher eukaryotes. Plos Biology. 4: e417. PMID 17147470 DOI: 10.1371/journal.pbio.0040417  0.549
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