Susan P Lees-Miller, Ph.D. - Publications

Biochemistry and Molecular Biology University of Calgary, Calgary, Alberta, Canada 
DNA Repair, Protein Kinase

138 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Hegde ML, Dutta A, Yang C, Mantha AK, Hegde PM, Pandey A, Sengupta S, Yu Y, Calsou P, Chen D, Lees-Miller SP, Mitra S. Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions. Oncotarget. PMID 27303920 DOI: 10.18632/oncotarget.9914  0.72
2015 Lees-Miller SP. Fumarate in DNA repair. Nature Cell Biology. 17: 1096-7. PMID 26316455 DOI: 10.1038/ncb3232  0.72
2015 Douglas P, Ye R, Morrice N, Britton S, Trinkle-Mulcahy L, Lees-Miller SP. Phosphorylation of SAF-A/hnRNP-U Serine 59 by Polo-Like Kinase 1 Is Required for Mitosis. Molecular and Cellular Biology. 35: 2699-713. PMID 25986610 DOI: 10.1128/MCB.01312-14  0.72
2015 Yang H, Matsumoto Y, Trujillo KM, Lees-Miller SP, Osley MA, Tomkinson AE. Role of the yeast DNA repair protein Nej1 in end processing during the repair of DNA double strand breaks by non-homologous end joining. Dna Repair. 31: 1-10. PMID 25942368 DOI: 10.1016/j.dnarep.2015.04.003  0.72
2015 Feng X, Li H, Dean M, Wilson HE, Kornaga E, Enwere EK, Tang P, Paterson A, Lees-Miller SP, Magliocco AM, Bebb G. Low ATM protein expression in malignant tumor as well as cancer-associated stroma are independent prognostic factors in a retrospective study of early-stage hormone-negative breast cancer. Breast Cancer Research : Bcr. 17: 65. PMID 25935535 DOI: 10.1186/s13058-015-0575-2  0.72
2015 Jette N, Lees-Miller SP. The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis. Progress in Biophysics and Molecular Biology. 117: 194-205. PMID 25550082 DOI: 10.1016/j.pbiomolbio.2014.12.003  0.72
2014 Lees-Miller SP. DNA double strand break repair in mitosis is suppressed by phosphorylation of XRCC4. Plos Genetics. 10: e1004598. PMID 25165869 DOI: 10.1371/journal.pgen.1004598  0.72
2014 Douglas P, Ye R, Trinkle-Mulcahy L, Neal JA, De Wever V, Morrice NA, Meek K, Lees-Miller SP. Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis. Bioscience Reports. 34. PMID 24844881 DOI: 10.1042/BSR20140051  0.72
2014 Kubota E, Williamson CT, Ye R, Elegbede A, Peterson L, Lees-Miller SP, Bebb DG. Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines. Cell Cycle (Georgetown, Tex.). 13: 2129-37. PMID 24841718 DOI: 10.4161/cc.29212  0.72
2014 Neal JA, Sugiman-Marangos S, VanderVere-Carozza P, Wagner M, Turchi J, Lees-Miller SP, Junop MS, Meek K. Unraveling the complexities of DNA-dependent protein kinase autophosphorylation. Molecular and Cellular Biology. 34: 2162-75. PMID 24687855 DOI: 10.1128/MCB.01554-13  0.72
2014 Williams GJ, Hammel M, Radhakrishnan SK, Ramsden D, Lees-Miller SP, Tainer JA. Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time. Dna Repair. 17: 110-20. PMID 24656613 DOI: 10.1016/j.dnarep.2014.02.009  0.72
2014 Radhakrishnan SK, Jette N, Lees-Miller SP. Non-homologous end joining: emerging themes and unanswered questions. Dna Repair. 17: 2-8. PMID 24582502 DOI: 10.1016/j.dnarep.2014.01.009  0.72
2014 Mahaney BL, Lees-Miller SP, Cobb JA. The C-terminus of Nej1 is critical for nuclear localization and non-homologous end-joining. Dna Repair. 14: 9-16. PMID 24369855 DOI: 10.1016/j.dnarep.2013.12.002  0.72
2013 Shawi M, Chu TW, Martinez-Marignac V, Yu Y, Gryaznov SM, Johnston JB, Lees-Miller SP, Assouline SE, Autexier C, Aloyz R. Telomerase contributes to fludarabine resistance in primary human leukemic lymphocytes. Plos One. 8: e70428. PMID 23922990 DOI: 10.1371/journal.pone.0070428  0.72
2013 Lee BS, Gapud EJ, Zhang S, Dorsett Y, Bredemeyer A, George R, Callen E, Daniel JA, Osipovich O, Oltz EM, Bassing CH, Nussenzweig A, Lees-Miller S, Hammel M, Chen BP, et al. Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination. Molecular and Cellular Biology. 33: 3568-79. PMID 23836881 DOI: 10.1128/MCB.00308-13  0.72
2013 Mahaney BL, Hammel M, Meek K, Tainer JA, Lees-Miller SP. XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 91: 31-41. PMID 23442139 DOI: 10.1139/bcb-2012-0058  0.72
2013 Wang C, Lees-Miller SP. Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining. International Journal of Radiation Oncology, Biology, Physics. 86: 440-9. PMID 23433795 DOI: 10.1016/j.ijrobp.2013.01.011  0.72
2013 McIntyre JB, Wu JS, Craighead PS, Phan T, Köbel M, Lees-Miller SP, Ghatage P, Magliocco AM, Doll CM. PIK3CA mutational status and overall survival in patients with cervical cancer treated with radical chemoradiotherapy. Gynecologic Oncology. 128: 409-14. PMID 23266353 DOI: 10.1016/j.ygyno.2012.12.019  0.72
2013 Rey M, Yang M, Burns KM, Yu Y, Lees-Miller SP, Schriemer DC. Nepenthesin from monkey cups for hydrogen/deuterium exchange mass spectrometry. Molecular & Cellular Proteomics : McP. 12: 464-72. PMID 23197791 DOI: 10.1074/mcp.M112.025221  0.72
2013 Doll CM, Aquino-Parsons C, Pintilie M, Klimowicz AC, Petrillo SK, Milosevic M, Craighead PS, Clarke B, Lees-Miller SP, Fyles AW, Magliocco AM. The significance of tumoral ERCC1 status in patients with locally advanced cervical cancer treated with chemoradiation therapy: a multicenter clinicopathologic analysis. International Journal of Radiation Oncology, Biology, Physics. 85: 721-7. PMID 22836058 DOI: 10.1016/j.ijrobp.2012.06.021  0.72
2012 Bebb DG, Lees-Miller SP. Predicting PARP inhibitor sensitivity and resistance. Cell Cycle (Georgetown, Tex.). 11: 4110. PMID 23099922 DOI: 10.4161/cc.22604  0.72
2012 Neumayer G, Helfricht A, Shim SY, Le HT, Lundin C, Belzil C, Chansard M, Yu Y, Lees-Miller SP, Gruss OJ, van Attikum H, Helleday T, Nguyen MD. Targeting protein for xenopus kinesin-like protein 2 (TPX2) regulates γ-histone 2AX (γ-H2AX) levels upon ionizing radiation. The Journal of Biological Chemistry. 287: 42206-22. PMID 23045526 DOI: 10.1074/jbc.M112.385674  0.72
2012 Williamson CT, Kubota E, Hamill JD, Klimowicz A, Ye R, Muzik H, Dean M, Tu L, Gilley D, Magliocco AM, McKay BC, Bebb DG, Lees-Miller SP. Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53. Embo Molecular Medicine. 4: 515-27. PMID 22416035 DOI: 10.1002/emmm.201200229  0.72
2012 Roy S, Andres SN, Vergnes A, Neal JA, Xu Y, Yu Y, Lees-Miller SP, Junop M, Modesti M, Meek K. XRCC4's interaction with XLF is required for coding (but not signal) end joining. Nucleic Acids Research. 40: 1684-94. PMID 22228831 DOI: 10.1093/nar/gkr1315  0.72
2012 Meek K, Lees-Miller SP, Modesti M. N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku. Nucleic Acids Research. 40: 2964-73. PMID 22167471 DOI: 10.1093/nar/gkr1211  0.72
2012 Hao D, Lau HY, Eliasziw M, Box A, Diaz R, Klimowicz AC, Shin B, Lees-Miller SP, Magliocco AM. Comparing ERCC1 protein expression, mRNA levels, and genotype in squamous cell carcinomas of the head and neck treated with concurrent chemoradiation stratified by HPV status. Head & Neck. 34: 785-91. PMID 22127805 DOI: 10.1002/hed.21817  0.72
2012 Weinfeld M, Lees-Miller SP. DNA Double-Strand Break Repair by Non-homologous End Joining and Its Clinical Relevance Dna Repair in Cancer Therapy. 161-189. DOI: 10.1016/B978-0-12-384999-1.10008-3  0.72
2011 Zolner AE, Abdou I, Ye R, Mani RS, Fanta M, Yu Y, Douglas P, Tahbaz N, Fang S, Dobbs T, Wang C, Morrice N, Hendzel MJ, Weinfeld M, Lees-Miller SP. Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage. Nucleic Acids Research. 39: 9224-37. PMID 21824916 DOI: 10.1093/nar/gkr647  0.72
2011 Hammel M, Rey M, Yu Y, Mani RS, Classen S, Liu M, Pique ME, Fang S, Mahaney BL, Weinfeld M, Schriemer DC, Lees-Miller SP, Tainer JA. XRCC4 protein interactions with XRCC4-like factor (XLF) create an extended grooved scaffold for DNA ligation and double strand break repair. The Journal of Biological Chemistry. 286: 32638-50. PMID 21775435 DOI: 10.1074/jbc.M111.272641  0.72
2011 Neal JA, Dang V, Douglas P, Wold MS, Lees-Miller SP, Meek K. Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylation. Molecular and Cellular Biology. 31: 1719-33. PMID 21300785 DOI: 10.1128/MCB.01298-10  0.72
2011 Williamson LM, Lees-Miller SP. Estrogen receptor α-mediated transcription induces cell cycle-dependent DNA double-strand breaks. Carcinogenesis. 32: 279-85. PMID 21112959 DOI: 10.1093/carcin/bgq255  0.72
2011 Lau HY, Brar S, Klimowicz AC, Petrillo SK, Hao D, Brockton NT, Kong CS, Lees-Miller SP, Magliocco AM. Prognostic significance of p16 in locally advanced squamous cell carcinoma of the head and neck treated with concurrent cisplatin and radiotherapy. Head & Neck. 33: 251-6. PMID 20848448 DOI: 10.1002/hed.21439  0.72
2010 Hammel M, Yu Y, Fang S, Lees-Miller SP, Tainer JA. XLF regulates filament architecture of the XRCC4·ligase IV complex. Structure (London, England : 1993). 18: 1431-42. PMID 21070942 DOI: 10.1016/j.str.2010.09.009  0.72
2010 Williams GJ, Lees-Miller SP, Tainer JA. Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks. Dna Repair. 9: 1299-306. PMID 21035407 DOI: 10.1016/j.dnarep.2010.10.001  0.72
2010 Dobbs TA, Tainer JA, Lees-Miller SP. A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation. Dna Repair. 9: 1307-14. PMID 21030321 DOI: 10.1016/j.dnarep.2010.09.019  0.72
2010 Doll CM, Prystajecky M, Eliasziw M, Klimowicz AC, Petrillo SK, Craighead PS, Hao D, Diaz R, Lees-Miller SP, Magliocco AM. Low ERCC1 mRNA and protein expression are associated with worse survival in cervical cancer patients treated with radiation alone. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 97: 352-9. PMID 20934765 DOI: 10.1016/j.radonc.2010.08.019  0.72
2010 Mani RS, Yu Y, Fang S, Lu M, Fanta M, Zolner AE, Tahbaz N, Ramsden DA, Litchfield DW, Lees-Miller SP, Weinfeld M. Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: implications for nonhomologous end joining. The Journal of Biological Chemistry. 285: 37619-29. PMID 20852255 DOI: 10.1074/jbc.M109.058719  0.72
2010 Beattie TL, Lees-Miller SP. Unraveling the roles of WRN and DNA-PKcs at telomeres. Aging. 2: 257-8. PMID 20519782 DOI: v2/n5/full/100150.html  0.72
2010 Kim M, Williamson CT, Prudhomme J, Bebb DG, Riabowol K, Lee PW, Lees-Miller SP, Mori Y, Rahman MM, McFadden G, Johnston RN. The viral tropism of two distinct oncolytic viruses, reovirus and myxoma virus, is modulated by cellular tumor suppressor gene status. Oncogene. 29: 3990-6. PMID 20473328 DOI: 10.1038/onc.2010.137  0.72
2010 Li A, Yu Y, Lee SC, Ishibashi T, Lees-Miller SP, Ausió J. Phosphorylation of histone H2A.X by DNA-dependent protein kinase is not affected by core histone acetylation, but it alters nucleosome stability and histone H1 binding. The Journal of Biological Chemistry. 285: 17778-88. PMID 20356835 DOI: 10.1074/jbc.M110.116426  0.72
2010 Douglas P, Moorhead G, Xu X, Lees-Miller SP. Choreographing the DNA damage response: PP6 joins the dance Cell Cycle. 9: 1221-1222. PMID 20234171  0.72
2010 Cobb JA, Lees-Miller SP. DNA double strand breaks: not all foci are created equal. Cell Cycle (Georgetown, Tex.). 9: 442-3. PMID 20130448  0.72
2010 Williamson CT, Muzik H, Turhan AG, Zamò A, O'Connor MJ, Bebb DG, Lees-Miller SP. ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors. Molecular Cancer Therapeutics. 9: 347-57. PMID 20124459 DOI: 10.1158/1535-7163.MCT-09-0872  0.72
2010 Douglas P, Zhong J, Ye R, Moorhead GB, Xu X, Lees-Miller SP. Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX. Molecular and Cellular Biology. 30: 1368-81. PMID 20065038 DOI: 10.1128/MCB.00741-09  0.72
2010 Hammel M, Yu Y, Mahaney BL, Cai B, Ye R, Phipps BM, Rambo RP, Hura GL, Pelikan M, So S, Abolfath RM, Chen DJ, Lees-Miller SP, Tainer JA. Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex. The Journal of Biological Chemistry. 285: 1414-23. PMID 19893054 DOI: 10.1074/jbc.M109.065615  0.72
2009 Ting NS, Pohorelic B, Yu Y, Lees-Miller SP, Beattie TL. The human telomerase RNA component, hTR, activates the DNA-dependent protein kinase to phosphorylate heterogeneous nuclear ribonucleoprotein A1. Nucleic Acids Research. 37: 6105-15. PMID 19656952 DOI: 10.1093/nar/gkp636  0.72
2009 Zhou T, Akopiants K, Mohapatra S, Lin PS, Valerie K, Ramsden DA, Lees-Miller SP, Povirk LF. Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks. Dna Repair. 8: 901-11. PMID 19505854 DOI: 10.1016/j.dnarep.2009.05.003  0.72
2009 Akopiants K, Zhou RZ, Mohapatra S, Valerie K, Lees-Miller SP, Lee KJ, Chen DJ, Revy P, de Villartay JP, Povirk LF. Requirement for XLF/Cernunnos in alignment-based gap filling by DNA polymerases lambda and mu for nonhomologous end joining in human whole-cell extracts. Nucleic Acids Research. 37: 4055-62. PMID 19420065 DOI: 10.1093/nar/gkp283  0.72
2009 Williams ES, Klingler R, Ponnaiya B, Hardt T, Schrock E, Lees-Miller SP, Meek K, Ullrich RL, Bailey SM. Telomere dysfunction and DNA-PKcs deficiency: characterization and consequence. Cancer Research. 69: 2100-7. PMID 19244120 DOI: 10.1158/0008-5472.CAN-08-2854  0.72
2009 Mahaney BL, Meek K, Lees-Miller SP. Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. The Biochemical Journal. 417: 639-50. PMID 19133841 DOI: 10.1042/BJ20080413  0.72
2009 Williamson LM, Williamson CT, Lees-Miller SP. DNA Double strand break repair: Mechanisms and therapeutic potential The Dna Damage Response: Implications On Cancer Formation and Treatment. 157-177. DOI: 10.1007/978-90-481-2561-6_8  0.72
2008 Meek K, Dang V, Lees-Miller SP. DNA-PK: the means to justify the ends? Advances in Immunology. 99: 33-58. PMID 19117531 DOI: 10.1016/S0065-2776(08)00602-0  0.72
2008 Yu Y, Mahaney BL, Yano K, Ye R, Fang S, Douglas P, Chen DJ, Lees-Miller SP. DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks. Dna Repair. 7: 1680-92. PMID 18644470 DOI: 10.1016/j.dnarep.2008.06.015  0.72
2008 Lees-Miller SP. PIKK-ing a new partner: a new role for PKB in the DNA damage response. Cancer Cell. 13: 379-80. PMID 18455120 DOI: 10.1016/j.ccr.2008.04.010  0.72
2007 Povirk LF, Zhou RZ, Ramsden DA, Lees-Miller SP, Valerie K. Phosphorylation in the serine/threonine 2609-2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts. Nucleic Acids Research. 35: 3869-78. PMID 17526517 DOI: 10.1093/nar/gkm339  0.72
2007 Lees-Miller SP. The double (strand break) life of Par-3. Nature Cell Biology. 9: 363-5. PMID 17401386 DOI: 10.1038/ncb0407-363  0.72
2007 Shi L, Qiu D, Zhao G, Corthesy B, Lees-Miller S, Reeves WH, Kao PN. Dynamic binding of Ku80, Ku70 and NF90 to the IL-2 promoter in vivo in activated T-cells. Nucleic Acids Research. 35: 2302-10. PMID 17389650 DOI: 10.1093/nar/gkm117  0.72
2007 Meek K, Douglas P, Cui X, Ding Q, Lees-Miller SP. trans Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining. Molecular and Cellular Biology. 27: 3881-90. PMID 17353268 DOI: 10.1128/MCB.02366-06  0.72
2007 Goodarzi AA, Douglas P, Moorhead GB, Lees-Miller SP. Utilizing protein phosphatase inhibitors to define PP2A as a regulator of ataxia-telangiectasia mutated. Methods in Molecular Biology (Clifton, N.J.). 365: 47-59. PMID 17200553 DOI: 10.1385/1-59745-267-X:47  0.72
2007 Douglas P, Cui X, Block WD, Yu Y, Gupta S, Ding Q, Ye R, Morrice N, Lees-Miller SP, Meek K. The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain. Molecular and Cellular Biology. 27: 1581-91. PMID 17158925 DOI: 10.1128/MCB.01962-06  0.72
2006 Goodarzi AA, Yu Y, Riballo E, Douglas P, Walker SA, Ye R, Härer C, Marchetti C, Morrice N, Jeggo PA, Lees-Miller SP. DNA-PK autophosphorylation facilitates Artemis endonuclease activity. The Embo Journal. 25: 3880-9. PMID 16874298 DOI: 10.1038/sj.emboj.7601255  0.72
2006 Merkle D, Block WD, Yu Y, Lees-Miller SP, Cramb DT. Analysis of DNA-dependent protein kinase-mediated DNA end joining by two-photon fluorescence cross-correlation spectroscopy. Biochemistry. 45: 4164-72. PMID 16566590 DOI: 10.1021/bi0524060  0.72
2006 Lees-Miller SP. Dysfunction of lamin A triggers a DNA damage response and cellular senescence. Dna Repair. 5: 286-9. PMID 16344005 DOI: 10.1016/j.dnarep.2005.10.007  0.72
2005 Cui X, Yu Y, Gupta S, Cho YM, Lees-Miller SP, Meek K. Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice. Molecular and Cellular Biology. 25: 10842-52. PMID 16314509 DOI: 10.1128/MCB.25.24.10842-10852.2005  0.72
2005 Block WD, Lees-Miller SP. Putative homologues of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and other components of the non-homologous end joining machinery in Dictyostelium discoideum. Dna Repair. 4: 1061-5. PMID 16112620 DOI: 10.1016/j.dnarep.2005.06.008  0.72
2005 Douglas P, Gupta S, Morrice N, Meek K, Lees-Miller SP. DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining. Dna Repair. 4: 1006-18. PMID 15941674 DOI: 10.1016/j.dnarep.2005.05.003  0.72
2005 Ting NS, Yu Y, Pohorelic B, Lees-Miller SP, Beattie TL. Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase. Nucleic Acids Research. 33: 2090-8. PMID 15824061 DOI: 10.1093/nar/gki342  0.72
2005 Peng Y, Woods RG, Beamish H, Ye R, Lees-Miller SP, Lavin MF, Bedford JS. Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM. Cancer Research. 65: 1670-7. PMID 15753361 DOI: 10.1158/0008-5472.CAN-04-3451  0.72
2005 Convery E, Shin EK, Ding Q, Wang W, Douglas P, Davis LS, Nickoloff JA, Lees-Miller SP, Meek K. Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs). Proceedings of the National Academy of Sciences of the United States of America. 102: 1345-50. PMID 15668400 DOI: 10.1073/pnas.0406466102  0.72
2004 Leonenko ZV, Merkle D, Shamrakov LG, Lees-Miller SP, Cramb DT. Examination of surface-bound Ku-DNA complexes in an aqueous environment using MAC mode atomic force microscopy. Biosensors & Bioelectronics. 20: 918-24. PMID 15530788 DOI: 10.1016/j.bios.2004.06.023  0.72
2004 Goodarzi AA, Jonnalagadda JC, Douglas P, Young D, Ye R, Moorhead GB, Lees-Miller SP, Khanna KK. Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A. The Embo Journal. 23: 4451-61. PMID 15510216 DOI: 10.1038/sj.emboj.7600455  0.72
2004 Kurz EU, Douglas P, Lees-Miller SP. Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species. The Journal of Biological Chemistry. 279: 53272-81. PMID 15489221 DOI: 10.1074/jbc.M406879200  0.72
2004 Block WD, Yu Y, Merkle D, Gifford JL, Ding Q, Meek K, Lees-Miller SP. Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends. Nucleic Acids Research. 32: 4351-7. PMID 15314205 DOI: 10.1093/nar/gkh761  0.72
2004 Kurz EU, Lees-Miller SP. DNA damage-induced activation of ATM and ATM-dependent signaling pathways. Dna Repair. 3: 889-900. PMID 15279774 DOI: 10.1016/j.dnarep.2004.03.029  0.72
2004 Reddy YV, Ding Q, Lees-Miller SP, Meek K, Ramsden DA. Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends. The Journal of Biological Chemistry. 279: 39408-13. PMID 15258142 DOI: 10.1074/jbc.M406432200  0.72
2004 Meek K, Gupta S, Ramsden DA, Lees-Miller SP. The DNA-dependent protein kinase: the director at the end. Immunological Reviews. 200: 132-41. PMID 15242401 DOI: 10.1111/j.0105-2896.2004.00162.x  0.72
2004 Merkle D, Lees-Miller SP, Cramb DT. Structure and dynamics of lipoplex formation examined using two-photon fluorescence cross-correlation spectroscopy. Biochemistry. 43: 7263-72. PMID 15182172 DOI: 10.1021/bi036133p  0.72
2004 Goodarzi AA, Lees-Miller SP. Biochemical characterization of the ataxia-telangiectasia mutated (ATM) protein from human cells. Dna Repair. 3: 753-67. PMID 15177184 DOI: 10.1016/j.dnarep.2004.03.041  0.72
2004 Ye R, Goodarzi AA, Kurz EU, Saito S, Higashimoto Y, Lavin MF, Appella E, Anderson CW, Lees-Miller SP. The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. Dna Repair. 3: 235-44. PMID 15177039 DOI: 10.1016/j.dnarep.2003.10.014  0.72
2004 Sawchuk DJ, Mansilla-Soto J, Alarcon C, Singha NC, Langen H, Bianchi ME, Lees-Miller SP, Nussenzweig MC, Cortes P. Ku70/Ku80 and DNA-dependent protein kinase catalytic subunit modulate RAG-mediated cleavage: implications for the enforcement of the 12/23 rule. The Journal of Biological Chemistry. 279: 29821-31. PMID 15123719 DOI: 10.1074/jbc.M403706200  0.72
2004 Block WD, Merkle D, Meek K, Lees-Miller SP. Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine. Nucleic Acids Research. 32: 1967-72. PMID 15060176 DOI: 10.1093/nar/gkh508  0.72
2004 Block WD, Yu Y, Lees-Miller SP. Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21. Nucleic Acids Research. 32: 997-1005. PMID 14872059 DOI: 10.1093/nar/gkh265  0.72
2003 Lees-Miller SP, Meek K. Repair of DNA double strand breaks by non-homologous end joining. Biochimie. 85: 1161-73. PMID 14726021 DOI: 10.1016/j.biochi.2003.10.011  0.72
2003 Lee JW, Inamdar KV, Hannah MF, Lees-Miller SP, Povirk LF. DNA end sequestration by DNA-dependent protein kinase and end joining of sterically constrained substrates in whole-cell extracts. Environmental and Molecular Mutagenesis. 42: 279-87. PMID 14673873 DOI: 10.1002/em.10197  0.72
2003 Yu Y, Wang W, Ding Q, Ye R, Chen D, Merkle D, Schriemer D, Meek K, Lees-Miller SP. DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination. Dna Repair. 2: 1239-52. PMID 14599745 DOI: 10.1016/S1568-7864(03)00143-5  0.72
2003 Goodarzi AA, Block WD, Lees-Miller SP. The role of ATM and ATR in DNA damage-induced cell cycle control. Progress in Cell Cycle Research. 5: 393-411. PMID 14593734  0.72
2003 Ding Q, Reddy YV, Wang W, Woods T, Douglas P, Ramsden DA, Lees-Miller SP, Meek K. Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair. Molecular and Cellular Biology. 23: 5836-48. PMID 12897153 DOI: 10.1128/MCB.23.16.5836-5848.2003  0.72
2003 Bodero AJ, Ye R, Lees-Miller SP. UV-light induces p38 MAPK-dependent phosphorylation of Bcl10. Biochemical and Biophysical Research Communications. 301: 923-6. PMID 12589800 DOI: 10.1016/S0006-291X(03)00063-9  0.72
2002 Merkle D, Douglas P, Moorhead GB, Leonenko Z, Yu Y, Cramb D, Bazett-Jones DP, Lees-Miller SP. The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation. Biochemistry. 41: 12706-14. PMID 12379113 DOI: 10.1021/bi0263558  0.72
2002 Sapkota GP, Deak M, Kieloch A, Morrice N, Goodarzi AA, Smythe C, Shiloh Y, Lees-Miller SP, Alessi DR. Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. The Biochemical Journal. 368: 507-16. PMID 12234250 DOI: 10.1042/BJ20021284  0.72
2002 Douglas P, Sapkota GP, Morrice N, Yu Y, Goodarzi AA, Merkle D, Meek K, Alessi DR, Lees-Miller SP. Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase. The Biochemical Journal. 368: 243-51. PMID 12186630 DOI: 10.1042/BJ20020973  0.72
2002 Beamish H, Kedar P, Kaneko H, Chen P, Fukao T, Peng C, Beresten S, Gueven N, Purdie D, Lees-Miller S, Ellis N, Kondo N, Lavin MF. Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM Journal of Biological Chemistry. 277: 30515-30523. PMID 12034743 DOI: 10.1074/jbc.M203801200  0.72
2002 Inamdar KV, Pouliot JJ, Zhou T, Lees-Miller SP, Rasouli-Nia A, Povirk LF. Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1. The Journal of Biological Chemistry. 277: 27162-8. PMID 12023295 DOI: 10.1074/jbc.M204688200  0.72
2002 Bochkareva E, Korolev S, Lees-Miller SP, Bochkarev A. Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA. The Embo Journal. 21: 1855-63. PMID 11927569 DOI: 10.1093/emboj/21.7.1855  0.72
2002 Saito S, Goodarzi AA, Higashimoto Y, Noda Y, Lees-Miller SP, Appella E, Anderson CW. ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation. The Journal of Biological Chemistry. 277: 12491-4. PMID 11875057 DOI: 10.1074/jbc.C200093200  0.72
2002 Leonenko ZV, Merkle D, Lees-Miller SP, Cramb DT. Lipid phase dependence of DNA-cationic phospholipid bilayer interactions examined using atomic force microscopy Langmuir. 18: 4873-4884. DOI: 10.1021/la0116239  0.72
2001 Douglas P, Moorhead GB, Ye R, Lees-Miller SP. Protein phosphatases regulate DNA-dependent protein kinase activity. The Journal of Biological Chemistry. 276: 18992-8. PMID 11376007 DOI: 10.1074/jbc.M011703200  0.72
2001 Chen S, Inamdar KV, Pfeiffer P, Feldmann E, Hannah MF, Yu Y, Lee JW, Zhou T, Lees-Miller SP, Povirk LF. Accurate in vitro end joining of a DNA double strand break with partially cohesive 3'-overhangs and 3'-phosphoglycolate termini: effect of Ku on repair fidelity. The Journal of Biological Chemistry. 276: 24323-30. PMID 11309379 DOI: 10.1074/jbc.M010544200  0.72
2001 Curman D, Cinel B, Williams DE, Rundle N, Block WD, Goodarzi AA, Hutchins JR, Clarke PR, Zhou BB, Lees-Miller SP, Andersen RJ, Roberge M. Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine. The Journal of Biological Chemistry. 276: 17914-9. PMID 11279124 DOI: 10.1074/jbc.M100728200  0.72
2001 Ye R, Bodero A, Zhou BB, Khanna KK, Lavin MF, Lees-Miller SP. The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner. The Journal of Biological Chemistry. 276: 4828-33. PMID 11096068 DOI: 10.1074/jbc.M004894200  0.72
2000 Achari Y, Lees-Miller SP. Detection of DNA-dependent protein kinase in extracts from human and rodent cells. Methods in Molecular Biology (Clifton, N.J.). 99: 85-97. PMID 10909079 DOI: 10.1385/1-59259-054-3:85  0.72
2000 Loewith R, Meijer M, Lees-Miller SP, Riabowol K, Young D. Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities. Molecular and Cellular Biology. 20: 3807-16. PMID 10805724 DOI: 10.1128/MCB.20.11.3807-3816.2000  0.72
2000 O'Neill T, Dwyer AJ, Ziv Y, Chan DW, Lees-Miller SP, Abraham RH, Lai JH, Hill D, Shiloh Y, Cantley LC, Rathbun GA. Utilization of oriented peptide libraries to identify substrate motifs selected by ATM. The Journal of Biological Chemistry. 275: 22719-27. PMID 10801797 DOI: 10.1074/jbc.M001002200  0.72
2000 Chan DW, Son SC, Block W, Ye R, Khanna KK, Wold MS, Douglas P, Goodarzi AA, Pelley J, Taya Y, Lavin MF, Lees-Miller SP. Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinase. The Journal of Biological Chemistry. 275: 7803-10. PMID 10713094 DOI: 10.1074/jbc.275.11.7803  0.72
1999 Ting NS, Chan DW, Lintott LG, Allalunis-Turner J, Lees-Miller SP. Protein-DNA complexes containing DNA-dependent protein kinase in crude extracts from human and rodent cells. Radiation Research. 151: 414-22. PMID 10190493 DOI: 10.2307/3579828  0.72
1999 D'Silva I, Pelletier JD, Lagueux J, D'Amours D, Chaudhry MA, Weinfeld M, Lees-Miller SP, Poirier GG. Relative affinities of poly(ADP-ribose) polymerase and DNA-dependent protein kinase for DNA strand interruptions. Biochimica Et Biophysica Acta. 1430: 119-26. PMID 10082940 DOI: 10.1016/S0167-4838(98)00278-7  0.72
1999 Chan DW, Ye R, Veillette CJ, Lees-Miller SP. DNA-dependent protein kinase phosphorylation sites in Ku 70/80 heterodimer. Biochemistry. 38: 1819-28. PMID 10026262 DOI: 10.1021/bi982584b  0.72
1999 Parkinson J, Lees-Miller SP, Everett RD. Herpes simplex virus type 1 immediate-early protein vmw110 induces the proteasome-dependent degradation of the catalytic subunit of DNA-dependent protein kinase. Journal of Virology. 73: 650-7. PMID 9847370  0.72
1998 Khanna KK, Keating KE, Kozlov S, Scott S, Gatei M, Hobson K, Taya Y, Gabrielli B, Chan D, Lees-Miller SP, Lavin MF. ATM associates with and phosphorylates p53: mapping the region of interaction. Nature Genetics. 20: 398-400. PMID 9843217 DOI: 10.1038/3882  0.72
1998 Bharti A, Kraeft SK, Gounder M, Pandey P, Jin S, Yuan ZM, Lees-Miller SP, Weichselbaum R, Weaver D, Chen LB, Kufe D, Kharbanda S. Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: implications for apoptosis. Molecular and Cellular Biology. 18: 6719-28. PMID 9774685  0.72
1998 Saleh A, Schieltz D, Ting N, McMahon SB, Litchfield DW, Yates JR, Lees-Miller SP, Cole MD, Brandl CJ. Tra1p is a component of the yeast Ada.Spt transcriptional regulatory complexes. The Journal of Biological Chemistry. 273: 26559-65. PMID 9756893 DOI: 10.1074/jbc.273.41.26559  0.72
1998 Woo RA, McLure KG, Lees-Miller SP, Rancourt DE, Lee PW. DNA-dependent protein kinase acts upstream of p53 in response to DNA damage. Nature. 394: 700-4. PMID 9716137 DOI: 10.1038/29343  0.72
1998 Chan DW, Gately DP, Urban S, Galloway AM, Lees-Miller SP, Yen T, Allalunis-Turner J. Lack of correlation between ATM protein expression and tumour cell radiosensitivity. International Journal of Radiation Biology. 74: 217-24. PMID 9712550 DOI: 10.1080/095530098141591  0.72
1998 Zhao EG, Song Q, Cross S, Misko I, Lees-Miller SP, Lavin MF. Resistance to etoposide-induced apoptosis in a Burkitt's lymphoma cell line. International Journal of Cancer. Journal International Du Cancer. 77: 755-62. PMID 9688310 DOI: 10.1002/(SICI)1097-0215(19980831)77:5<755::AID-IJC15>3.0.CO;2-0  0.72
1998 Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP. DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45. The Journal of Biological Chemistry. 273: 2136-45. PMID 9442054 DOI: 10.1074/jbc.273.4.2136  0.72
1997 Weinfeld M, Chaudhry MA, D'Amours D, Pelletier JD, Poirier GG, Povirk LF, Lees-Miller SP. Interaction of DNA-dependent protein kinase and poly(ADP-ribose) polymerase with radiation-induced DNA strand breaks. Radiation Research. 148: 22-8. PMID 9216614 DOI: 10.2307/3579534  0.72
1997 Sullivan KE, Veksler E, Lederman H, Lees-Miller SP. Cell cycle checkpoints and DNA repair in Nijmegen breakage syndrome. Clinical Immunology and Immunopathology. 82: 43-8. PMID 9000041 DOI: 10.1006/clin.1996.4275  0.72
1996 Chan DW, Mody CH, Ting NS, Lees-Miller SP. Purification and characterization of the double-stranded DNA-activated protein kinase, DNA-PK, from human placenta. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 74: 67-73. PMID 9035691  0.72
1996 Lees-Miller SP. The DNA-dependent protein kinase, DNA-PK: 10 Years and no ends in sight Biochemistry and Cell Biology. 74: 503-512. PMID 8960356  0.72
1996 Lees-Miller SP, Long MC, Kilvert MA, Lam V, Rice SA, Spencer CA. Attenuation of DNA-dependent protein kinase activity and its catalytic subunit by the herpes simplex virus type 1 transactivator ICP0. Journal of Virology. 70: 7471-7. PMID 8892865  0.72
1996 Song Q, Burrows SR, Smith G, Lees-Miller SP, Kumar S, Chan DW, Trapani JA, Alnemri E, Litwack G, Lu H, Moss DJ, Jackson S, Lavin MF. Interleukin-1 beta-converting enzyme-like protease cleaves DNA-dependent protein kinase in cytotoxic T cell killing. The Journal of Experimental Medicine. 184: 619-26. PMID 8760815  0.72
1996 Song Q, Lees-Miller SP, Kumar S, Zhang N, Chan DW, Smith GCM, Jackson SP, Alnemri ES, Litwack G, Khanna KK, Lavin MF. DNA-dependent protein kinase catalytic subunit: A target for an ICE-like protease in apoptosis Embo Journal. 15: 3238-3246. PMID 8670824  0.72
1996 Chan DW, Lees-Miller SP. The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit Journal of Biological Chemistry. 271: 8936-8941. PMID 8621537 DOI: 10.1074/jbc.271.15.8936  0.72
1995 Lees-Miller SP, Godbout R, Chan DW, Weinfeld M, Day RS, Barron GM, Allalunis-Turner J. Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line. Science (New York, N.Y.). 267: 1183-5. PMID 7855602  0.72
1995 Hartley KO, Gell D, Smith GC, Zhang H, Divecha N, Connelly MA, Admon A, Lees-Miller SP, Anderson CW, Jackson SP. DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell. 82: 849-56. PMID 7671312 DOI: 10.1016/0092-8674(95)90482-4  0.72
1995 Allalunis-Turner MJ, Lintott LG, Barron GM, Day RS, Lees-Miller SP. Lack of correlation between DNA-dependent protein kinase activity and tumor cell radiosensitivity. Cancer Research. 55: 5200-2. PMID 7585574  0.72
1994 Anderson CW, Connelly MA, Zhang H, Sipley JD, Lees-Miller SP, Sakaguchi K, Ullrich SJ, Jackson SP, Appella E. The human DNA-activated protein kinase, DNA-PK, is activated by DNA breaks and phosphorylates nuclear DNA-binding protein substrates on serines and threonines following by glutamine Journal of Protein Chemistry. 13: 500-506.  0.72
1993 Fiscella M, Ullrich SJ, Zambrano N, Shields MT, Lin D, Lees-Miller SP, Anderson CW, Mercer WE, Appella E. Mutation of the serine 15 phosphorylation site of human p53 reduces the ability of p53 to inhibit cell cycle progression. Oncogene. 8: 1519-28. PMID 8502477  0.72
1993 Liu SH, Ma JT, Yueh AY, Lees-Miller SP, Anderson CW, Ng SY. The carboxyl-terminal transactivation domain of human serum response factor contains DNA-activated protein kinase phosphorylation sites. The Journal of Biological Chemistry. 268: 21147-54. PMID 8407951  0.72
1993 Abate C, Baker SJ, Lees-Miller SP, Anderson CW, Marshak DR, Curran T. Dimerization and DNA binding alter phosphorylation of Fos and Jun. Proceedings of the National Academy of Sciences of the United States of America. 90: 6766-70. PMID 8341696  0.72
1993 Ullrich SJ, Sakaguchi K, Lees-Miller SP, Fiscella M, Mercer WE, Anderson CW, Appella E. Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53. Proceedings of the National Academy of Sciences of the United States of America. 90: 5954-8. PMID 8327466  0.72
1992 Anderson CW, Lees-Miller SP. The nuclear serine/threonine protein kinase DNA-PK. Critical Reviews in Eukaryotic Gene Expression. 2: 283-314. PMID 1486241  0.72
1992 Lees-Miller SP, Sakaguchi K, Ullrich SJ, Appella E, Anderson CW. Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Molecular and Cellular Biology. 12: 5041-9. PMID 1406679  0.72
1991 Lees-Miller SP, Anderson CW. The DNA-activated protein kinase, DNA-PK: a potential coordinator of nuclear events. Cancer Cells (Cold Spring Harbor, N.Y. : 1989). 3: 341-6. PMID 1751287  0.72
1991 Chen YR, Lees-Miller SP, Tegtmeyer P, Anderson CW. The human DNA-activated protein kinase phosphorylates simian virus 40 T antigen at amino- and carboxy-terminal sites. Journal of Virology. 65: 5131-40. PMID 1654434  0.72
1990 Lees-Miller SP, Chen YR, Anderson CW. Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen. Molecular and Cellular Biology. 10: 6472-81. PMID 2247067  0.72
1989 Lees-Miller SP, Anderson CW. The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two NH2-terminal threonine residues. The Journal of Biological Chemistry. 264: 17275-80. PMID 2507541  0.72
1989 Lees-Miller SP, Anderson CW. Two human 90-kDa heat shock proteins are phosphorylated in vivo at conserved serines that are phosphorylated in vitro by casein kinase II. The Journal of Biological Chemistry. 264: 2431-7. PMID 2492519  0.72
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