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Arvin C. Dar, Ph.D. - Publications

Affiliations: 
Structural and Chemical Biology Icahn School of Medicine at Mount Sinai, New York, NY, United States 
Website:
http://www.mountsinai.org/profiles/arvin-dar
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29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Marsiglia WM, Chow A, Khan ZM, He L, Dar AC. Live-cell target engagement of allosteric MEKi on MEK-RAF/KSR-14-3-3 complexes. Nature Chemical Biology. PMID 37919548 DOI: 10.1038/s41589-023-01454-8  0.322
2023 Rialdi A, Duffy M, Scopton AP, Fonseca F, Zhao JN, Schwarz M, Molina-Sanchez P, Mzoughi S, Arceci E, Abril-Fornaguera J, Meadows A, Ruiz de Galarreta M, Torre D, Reyes K, Lim YT, ... ... Dar AC, et al. WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma. Nature Cancer. PMID 37537299 DOI: 10.1038/s43018-023-00609-9  0.313
2022 Chow A, Khan ZM, Marsiglia WM, Dar AC. Conformational control and regulation of the pseudokinase KSR via small molecule binding interactions. Methods in Enzymology. 667: 365-402. PMID 35525547 DOI: 10.1016/bs.mie.2022.03.039  0.452
2021 Smith RHB, Khan ZM, Ung PM, Scopton AP, Silber L, Mack SM, Real AM, Schlessinger A, Dar AC. Type II Binders Targeting the "GLR-Out" Conformation of the Pseudokinase STRADα. Biochemistry. PMID 33440120 DOI: 10.1021/acs.biochem.0c00714  0.303
2020 Khan ZM, Real AM, Marsiglia WM, Chow A, Duffy ME, Yerabolu JR, Scopton AP, Dar AC. Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature. PMID 32927473 DOI: 10.1038/S41586-020-2760-4  0.437
2019 Yu JX, Craig AJ, Duffy ME, Villacorta-Martin C, Miguela V, Ruiz de Galarreta M, Scopton AP, Silber L, Maldonado AY, Rialdi A, Guccione E, Lujambio A, Villanueva A, Dar AC. Phenotype-based screens with conformation-specific inhibitors reveal p38 gamma and delta as targets for HCC polypharmacology. Molecular Cancer Therapeutics. PMID 31213506 DOI: 10.1158/1535-7163.Mct-18-0571  0.409
2019 Huang KL, Wu Y, Primeau T, Wang YT, Gao Y, McMichael JF, Scott AD, Cao S, Wendl MC, Johnson KJ, Ruggles K, Held J, Payne SH, Davies SR, Dar A, et al. Regulated Phosphosignaling Associated with Breast Cancer Subtypes and Druggability. Molecular & Cellular Proteomics : McP. PMID 31196969 DOI: 10.1074/Mcp.Ra118.001243  0.565
2019 Ung PMU, Sonoshita M, Scopton AP, Dar AC, Cagan RL, Schlessinger A. Integrated computational and Drosophila cancer model platform captures previously unappreciated chemicals perturbing a kinase network. Plos Computational Biology. 15: e1006878. PMID 31026276 DOI: 10.1371/Journal.Pcbi.1006878  0.429
2018 Sonoshita M, Scopton AP, Ung PMU, Murray MA, Silber L, Maldonado AY, Real A, Schlessinger A, Cagan RL, Dar AC. A whole-animal platform to advance a clinical kinase inhibitor into new disease space. Nature Chemical Biology. PMID 29355849 DOI: 10.1038/Nchembio.2556  0.497
2016 Dhawan NS, Scopton AP, Dar AC. Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Nature. PMID 27556948 DOI: 10.1038/Nature19327  0.441
2015 Mendez AS, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV, Bernales S, Shokat KM, Walter P. Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic. Elife. 4. PMID 25986605 DOI: 10.7554/Elife.05434  0.759
2015 Mendez AS, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV, Bernales S, Shokat KM, Walter P. Author response: Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic Elife. DOI: 10.7554/Elife.05434.022  0.61
2015 Dar A. Abstract SY14-02: Regulation of kinase signaling complexes with small molecule inhibitors Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Sy14-02  0.505
2015 Ramkumar P, Levin RS, Sansó M, Jatiani S, Dar AC, Fisher RP, Shokat KM, Reddy EP. Abstract 2450: Identifying novel substrates of PLK2 using a chemical genetics approach Cancer Research. 75: 2450-2450. DOI: 10.1158/1538-7445.Am2015-2450  0.705
2013 Dar AC. A pickup in pseudokinase activity. Biochemical Society Transactions. 41: 987-94. PMID 23863168 DOI: 10.1042/Bst20130110  0.59
2013 Zhang C, Lopez MS, Dar AC, Ladow E, Finkbeiner S, Yun CH, Eck MJ, Shokat KM. Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology. Acs Chemical Biology. 8: 1931-8. PMID 23841803 DOI: 10.1021/Cb400376P  0.763
2012 Dar AC, Das TK, Shokat KM, Cagan RL. Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature. 486: 80-4. PMID 22678283 DOI: 10.1038/Nature11127  0.587
2011 Dar AC, Shokat KM. The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling. Annual Review of Biochemistry. 80: 769-95. PMID 21548788 DOI: 10.1146/Annurev-Biochem-090308-173656  0.715
2011 Brennan DF, Dar AC, Hertz NT, Chao WC, Burlingame AL, Shokat KM, Barford D. A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK. Nature. 472: 366-9. PMID 21441910 DOI: 10.1038/Nature09860  0.791
2011 Brennan DF, Dar AC, Hertz NT, Chao W, Burlingame AL, Shokat KM, Barford D. A Raf-Induced Allosteric Transition of Ksr Stimulates Ksr and Raf Phosphorylation of Mek Nature. 472: 366. DOI: 10.2210/Pdb2Y4I/Pdb  0.742
2010 Hertz NT, Wang BT, Allen JJ, Zhang C, Dar AC, Burlingame AL, Shokat KM. Chemical genetic approach for kinase-substrate mapping by covalent capture of thiophosphopeptides and analysis by mass spectrometry. Current Protocols in Chemical Biology. 2: 15-36. PMID 23836541 DOI: 10.1002/9780470559277.Ch090201  0.722
2008 Seo EJ, Liu F, Kawagishi-Kobayashi M, Ung TL, Cao C, Dar AC, Sicheri F, Dever TE. Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein. Proceedings of the National Academy of Sciences of the United States of America. 105: 16894-9. PMID 18971339 DOI: 10.1073/Pnas.0805524105  0.718
2008 Dar AC, Lopez MS, Shokat KM. Small molecule recognition of c-Src via the Imatinib-binding conformation. Chemistry & Biology. 15: 1015-22. PMID 18940662 DOI: 10.1016/J.Chembiol.2008.09.007  0.719
2007 Dever TE, Dar AC, Sicheri F. 12 The eIF2α Kinases Cold Spring Harbor Monograph Archive. 48: 319-344. DOI: 10.1101/087969767.48.319  0.725
2005 Dey M, Cao C, Dar AC, Tamura T, Ozato K, Sicheri F, Dever TE. Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition. Cell. 122: 901-13. PMID 16179259 DOI: 10.1016/J.Cell.2005.06.041  0.697
2005 Dar AC, Dever TE, Sicheri F. Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR. Cell. 122: 887-900. PMID 16179258 DOI: 10.1016/J.Cell.2005.06.044  0.695
2005 Dey M, Trieselmann B, Locke EG, Lu J, Cao C, Dar AC, Krishnamoorthy T, Dong J, Sicheri F, Dever TE. PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alpha. Molecular and Cellular Biology. 25: 3063-75. PMID 15798194 DOI: 10.1128/Mcb.25.8.3063-3075.2005  0.723
2003 Zigmond SH, Evangelista M, Boone C, Yang C, Dar AC, Sicheri F, Forkey J, Pring M. Formin leaky cap allows elongation in the presence of tight capping proteins. Current Biology : Cb. 13: 1820-3. PMID 14561409 DOI: 10.1016/J.Cub.2003.09.057  0.548
2002 Dar AC, Sicheri F. X-ray crystal structure and functional analysis of vaccinia virus K3L reveals molecular determinants for PKR subversion and substrate recognition. Molecular Cell. 10: 295-305. PMID 12191475 DOI: 10.1016/S1097-2765(02)00590-7  0.612
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