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Jeremy R. Lohman, Ph.D. - Publications

Affiliations: 
Biochemistry Purdue University, West Lafayette, IN, United States 
Area:
Natural Product Biosynthesis
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36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Benjamin AB, Stunkard LM, Ling J, Nice JN, Lohman JR. Structures of chloramphenicol acetyltransferase III and Escherichia coli β-ketoacylsynthase III co-crystallized with partially hydrolysed acetyl-oxa(dethia)CoA. Acta Crystallographica. Section F, Structural Biology Communications. 79: 61-69. PMID 36862094 DOI: 10.1107/S2053230X23001206  0.314
2021 Stunkard LM, Kick BJ, Lohman JR. Structures of LnmK, a Bifunctional Acyltransferase/Decarboxylase, with Substrate Analogues Reveal the Basis for Selectivity and Stereospecificity. Biochemistry. 60: 365-372. PMID 33482062 DOI: 10.1021/acs.biochem.0c00893  0.329
2020 Lohman JR, Shen B. The LnmK Bifunctional Acyltransferase/Decarboxylase Specifying (2)-Methylmalonyl-CoA and Employing Substrate-Assisted Catalysis for Polyketide Biosynthesis. Biochemistry. PMID 33095002 DOI: 10.1021/acs.biochem.0c00749  0.508
2019 Stunkard LM, Dixon AD, Huth TJ, Lohman JR. Sulfonate/nitro bearing methylmalonyl-thioester isosteres applied to methylmalonyl-CoA decarboxylase structure-function studies. Journal of the American Chemical Society. PMID 30869886 DOI: 10.1021/Jacs.9B00650  0.422
2018 Kwong T, Ma M, Pan G, Hindra, Yang D, Yang C, Lohman JR, Rudolf JD, Cleveland JL, Shen B. P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities. Biochemistry. PMID 30070831 DOI: 10.1021/Acs.Biochem.8B00623  0.77
2018 Chang CY, Lohman JR, Huang T, Michalska K, Bigelow L, Rudolf JD, Jedrzejczak R, Yan X, Ma M, Babnigg G, Joachimiak A, Phillips GN, Shen B. Structural Insights into the Free-standing Condensation Enzyme SgcC5 Catalyzing Ester Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027. Biochemistry. PMID 29533601 DOI: 10.1021/Acs.Biochem.8B00174  0.742
2018 Guo X, Crnovcic I, Chang CY, Luo J, Lohman JR, Papinski M, Bechthold A, Horsman GP, Shen B. PokMT1 from the polyketomycin biosynthetic machinery of Streptomyces diastatochromogenes Tü6028 belongs to the emerging family of C-methyltransferases that act on CoA-activated aromatic substrates. Biochemistry. PMID 29341603 DOI: 10.1021/Acs.Biochem.7B01219  0.581
2017 Annaval T, Rudolf JD, Chang CY, Lohman JR, Kim Y, Bigelow L, Jedrzejczak R, Babnigg G, Joachimiak A, Phillips GN, Shen B. Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis. Acs Omega. 2: 5159-5169. PMID 28884166 DOI: 10.1021/acsomega.7b00933  0.735
2016 Yan X, Ge H, Huang T, Hindra, Yang D, Teng Q, Crnovčić I, Li X, Rudolf JD, Lohman JR, Gansemans Y, Zhu X, Huang Y, Zhao LX, Jiang Y, et al. Strain Prioritization and Genome Mining for Enediyne Natural Products. Mbio. 7. PMID 27999165 DOI: 10.1128/Mbio.02104-16  0.723
2016 Chang CY, Lohman JR, Cao H, Tan K, Rudolf JD, Ma M, Xu W, Bingman CA, Yennamalli RM, Bigelow L, Babnigg G, Yan X, Joachimiak A, Phillips GN, Shen B. Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase that Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate in Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus. Biochemistry. PMID 27560143 DOI: 10.1021/Acs.Biochem.6B00713  0.741
2016 Huang T, Chang CY, Lohman JR, Rudolf JD, Kim Y, Chang C, Yang D, Ma M, Yan X, Crnovcic I, Bigelow L, Clancy S, Bingman CA, Yennamalli RM, Babnigg G, et al. Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027. The Journal of Antibiotics. PMID 27406907 DOI: 10.1038/Ja.2016.88  0.746
2015 Rudolf JD, Bigelow L, Chang C, Cuff ME, Lohman JR, Chang CY, Ma M, Yang D, Clancy S, Babnigg G, Joachimiak A, Phillips GN, Shen B. Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892. Biochemistry. PMID 26512730 DOI: 10.1021/Acs.Biochem.5B01008  0.696
2015 Lohman JR, Ma M, Osipiuk J, Nocek B, Kim Y, Chang C, Cuff M, Mack J, Bigelow L, Li H, Endres M, Babnigg G, Joachimiak A, Phillips GN, Shen B. Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases. Proceedings of the National Academy of Sciences of the United States of America. PMID 26420866 DOI: 10.1073/Pnas.1515460112  0.55
2015 Ma M, Lohman JR, Liu T, Shen B. C-S bond cleavage by a polyketide synthase domain. Proceedings of the National Academy of Sciences of the United States of America. 112: 10359-64. PMID 26240335 DOI: 10.1073/Pnas.1508437112  0.586
2015 Huang SX, Yun BS, Ma M, Basu HS, Church DR, Ingenhorst G, Huang Y, Yang D, Lohman JR, Tang GL, Ju J, Liu T, Wilding G, Shen B. Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species. Proceedings of the National Academy of Sciences of the United States of America. 112: 8278-83. PMID 26056295 DOI: 10.1073/Pnas.1506761112  0.522
2015 Park H, González ÀL, Yildirim I, Tran T, Lohman JR, Fang P, Guo M, Disney MD. Crystallographic and Computational Analyses of AUUCU Repeating RNA That Causes Spinocerebellar Ataxia Type 10 (SCA10). Biochemistry. 54: 3851-9. PMID 26039897 DOI: 10.1021/Acs.Biochem.5B00551  0.301
2015 Shen B, Hindra, Yan X, Huang T, Ge H, Yang D, Teng Q, Rudolf JD, Lohman JR. Enediynes: Exploration of microbial genomics to discover new anticancer drug leads. Bioorganic & Medicinal Chemistry Letters. 25: 9-15. PMID 25434000 DOI: 10.1016/J.Bmcl.2014.11.019  0.678
2015 Lohman J, Joachimiak A, Phillips Jr G, Shen B. Structural and evolutionary relationships of ketosynthase domains from modular polyketide synthases Planta Medica. 81. DOI: 10.1055/s-0035-1556231  0.424
2014 Seo JW, Ma M, Kwong T, Ju J, Lim SK, Jiang H, Lohman JR, Yang C, Cleveland J, Zazopoulos E, Farnet CM, Shen B. Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues. Biochemistry. 53: 7854-65. PMID 25405956 DOI: 10.1021/Bi501396V  0.612
2014 Hindra, Huang T, Yang D, Rudolf JD, Xie P, Xie G, Teng Q, Lohman JR, Zhu X, Huang Y, Zhao LX, Jiang Y, Duan Y, Shen B. Strain prioritization for natural product discovery by a high-throughput real-time PCR method. Journal of Natural Products. 77: 2296-303. PMID 25238028 DOI: 10.1021/Np5006168  0.685
2014 Lohman JR, Ma M, Cuff ME, Bigelow L, Bearden J, Babnigg G, Joachimiak A, Phillips GN, Shen B. The crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteins. Proteins. 82: 1210-8. PMID 25050442 DOI: 10.1002/Prot.24485  0.535
2014 Ge HM, Huang T, Rudolf JD, Lohman JR, Huang SX, Guo X, Shen B. Enediyne polyketide synthases stereoselectively reduce the β-ketoacyl intermediates to β-D-hydroxyacyl intermediates in enediyne core biosynthesis. Organic Letters. 16: 3958-61. PMID 25019332 DOI: 10.1021/Ol501767V  0.675
2014 Yin M, Yan Y, Lohman JR, Huang SX, Ma M, Zhao GR, Xu LH, Xiang W, Shen B. Cycloheximide and actiphenol production in Streptomyces sp. YIM56141 governed by single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase. Organic Letters. 16: 3072-5. PMID 24815182 DOI: 10.1021/Ol501179W  0.553
2014 Xie P, Ma M, Rateb ME, Shaaban KA, Yu Z, Huang SX, Zhao LX, Zhu X, Yan Y, Peterson RM, Lohman JR, Yang D, Yin M, Rudolf JD, Jiang Y, et al. Biosynthetic potential-based strain prioritization for natural product discovery: a showcase for diterpenoid-producing actinomycetes. Journal of Natural Products. 77: 377-87. PMID 24484381 DOI: 10.1021/Np401063S  0.705
2014 Childs-Disney JL, Yildirim I, Park H, Lohman JR, Guan L, Tran T, Sarkar P, Schatz GC, Disney MD. Structure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity. Acs Chemical Biology. 9: 538-50. PMID 24341895 DOI: 10.1021/Cb4007387  0.303
2013 Huang SX, Lohman JR, Huang T, Shen B. A new member of the 4-methylideneimidazole-5-one-containing aminomutase family from the enediyne kedarcidin biosynthetic pathway. Proceedings of the National Academy of Sciences of the United States of America. 110: 8069-74. PMID 23633564 DOI: 10.1073/Pnas.1304733110  0.545
2013 Ma M, Kwong T, Lim SK, Ju J, Lohman JR, Shen B. Post-polyketide synthase steps in iso-migrastatin biosynthesis, featuring tailoring enzymes with broad substrate specificity. Journal of the American Chemical Society. 135: 2489-92. PMID 23394593 DOI: 10.1021/Ja4002635  0.571
2013 Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B. Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics. Molecular Biosystems. 9: 478-91. PMID 23360970 DOI: 10.1039/C3Mb25523A  0.737
2013 Lohman JR, Bingman CA, Phillips GN, Shen B. Structure of the bifunctional acyltransferase/decarboxylase LnmK from the leinamycin biosynthetic pathway revealing novel activity for a double-hot-dog fold. Biochemistry. 52: 902-11. PMID 23320975 DOI: 10.1021/Bi301652Y  0.573
2012 Lohman JR, Shen B. 4-methylideneimidazole-5-one-containing aminomutases in enediyne biosynthesis. Methods in Enzymology. 516: 299-319. PMID 23034235 DOI: 10.1016/B978-0-12-394291-3.00007-1  0.544
2012 Coonrod LA, Lohman JR, Berglund JA. Utilizing the GAAA tetraloop/receptor to facilitate crystal packing and determination of the structure of a CUG RNA helix. Biochemistry. 51: 8330-7. PMID 23025897 DOI: 10.1021/Bi300829W  0.301
2011 Yin M, Lu T, Zhao LX, Chen Y, Huang SX, Lohman JR, Xu LH, Jiang CL, Shen B. The missing C-17 O-methyltransferase in geldanamycin biosynthesis. Organic Letters. 13: 3726-9. PMID 21682254 DOI: 10.1021/Ol201383W  0.523
2008 Lohman JR, Olson AC, Remington SJ. Atomic resolution structures of Escherichia coli and Bacillus anthracis malate synthase A: comparison with isoform G and implications for structure-based drug discovery. Protein Science : a Publication of the Protein Society. 17: 1935-45. PMID 18714089 DOI: 10.1110/Ps.036269.108  0.626
2008 Lohman JR, Remington SJ. Development of a family of redox-sensitive green fluorescent protein indicators for use in relatively oxidizing subcellular environments. Biochemistry. 47: 8678-88. PMID 18652491 DOI: 10.1021/Bi800498G  0.584
2008 Gloss LM, Topping TB, Binder AK, Lohman JR. Kinetic folding of Haloferax volcanii and Escherichia coli dihydrofolate reductases: haloadaptation by unfolded state destabilization at high ionic strength. Journal of Molecular Biology. 376: 1451-62. PMID 18207162 DOI: 10.1016/J.Jmb.2007.12.056  0.652
2002 Wright DB, Banks DD, Lohman JR, Hilsenbeck JL, Gloss LM. The effect of salts on the activity and stability of Escherichia coli and Haloferax volcanii dihydrofolate reductases. Journal of Molecular Biology. 323: 327-44. PMID 12381324 DOI: 10.1016/S0022-2836(02)00916-6  0.672
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