Ulrich Dirnagl - Publications

Affiliations: 
Experimental Neurology Charité - Universitätsmedizin Berlin, Germany 

189 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Malik AR, Lips J, Gorniak-Walas M, Broekaart DWM, Asaro A, Kuffner MTC, Hoffmann CJ, Kikhia M, Dopatka M, Boehm-Sturm P, Mueller S, Dirnagl U, Aronica E, Harms C, Willnow TE. SorCS2 facilitates release of endostatin from astrocytes and controls post-stroke angiogenesis. Glia. PMID 31898841 DOI: 10.1002/Glia.23778  0.38
2019 Foddis M, Winek K, Bentele K, Mueller S, Blumenau S, Reichhart N N, Crespo-Garcia S, Harnett D, Ivanov A, Meisel A, Joussen A, Strauss O, Beule D, Dirnagl U, Sassi C. An exploratory investigation of brain collateral circulation plasticity after cerebral ischemia in two experimental C57BL/6 mouse models. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X19827251. PMID 31549895 DOI: 10.1177/0271678X19827251  0.384
2018 Oyama N, Winek K, Bäcker-Koduah P, Zhang T, Dames C, Werich M, Kershaw O, Meisel C, Meisel A, Dirnagl U. Exploratory Investigation of Intestinal Function and Bacterial Translocation After Focal Cerebral Ischemia in the Mouse. Frontiers in Neurology. 9: 937. PMID 30510535 DOI: 10.3389/Fneur.2018.00937  0.382
2018 Khalil AA, Mueller S, Foddis M, Mosch L, Lips J, Przesdzing I, Temme S, Flögel U, Dirnagl U, Boehm-Sturm P. Longitudinal 19F magnetic resonance imaging of brain oxygenation in a mouse model of vascular cognitive impairment using a cryogenic radiofrequency coil. Magma (New York, N.Y.). PMID 30421249 DOI: 10.1007/S10334-018-0712-X  0.5
2018 Crespo-Garcia S, Reichhart N, Skosyrski S, Foddis M, Wu J, Figura A, Herrspiegel C, Füchtemeier M, Sassi C, Dirnagl U, Joussen AM, Strauss O. Individual and temporal variability of the retina after chronic bilateral common carotid artery occlusion (BCCAO). Plos One. 13: e0193961. PMID 29547662 DOI: 10.1371/Journal.Pone.0193961  0.316
2017 Emmrich JV, Neher JJ, Boehm-Sturm P, Endres M, Dirnagl U, Harms C. Stage 1 Registered Report: Effect of deficient phagocytosis on neuronal survival and neurological outcome after temporary middle cerebral artery occlusion (tMCAo). F1000research. 6: 1827. PMID 29152223 DOI: 10.12688/F1000Research.12537.1  0.39
2017 Koch S, Mueller S, Foddis M, Bienert T, von Elverfeldt D, Knab F, Farr TD, Bernard R, Dopatka M, Rex A, Dirnagl U, Harms C, Boehm-Sturm P. Atlas registration for edema-corrected MRI lesion volume in mouse stroke models. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X17726635. PMID 28829217 DOI: 10.1177/0271678X17726635  0.33
2017 Dam K, Füchtemeier M, Farr TD, Boehm-Sturm P, Foddis M, Dirnagl U, Malysheva O, Caudill MA, Jadavji NM. Increased homocysteine levels impair reference memory and reduce cortical levels of acetylcholine in a mouse model of vascular cognitive impairment. Behavioural Brain Research. 321: 201-208. PMID 28087280 DOI: 10.1016/J.Bbr.2016.12.041  0.733
2017 Boehm-Sturm P, Füchtemeier M, Foddis M, Mueller S, Trueman RC, Zille M, Rinnenthal JL, Kypraios T, Shaw L, Dirnagl U, Farr TD. Neuroimaging Biomarkers Predict Brain Structural Connectivity Change in a Mouse Model of Vascular Cognitive Impairment. Stroke. PMID 28070001 DOI: 10.1161/Strokeaha.116.014394  0.304
2016 Winek K, Dirnagl U, Meisel A. The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 27714645 DOI: 10.1007/S13311-016-0475-X  0.317
2016 Donath S, An J, Lee SL, Gertz K, Datwyler AL, Harms U, Müller S, Farr TD, Füchtemeier M, Lättig-Tünnemann G, Lips J, Foddis M, Mosch L, Bernard R, Grittner U, ... ... Dirnagl U, et al. Interaction of ARC and Daxx: A Novel Endogenous Target to Preserve Motor Function and Cell Loss after Focal Brain Ischemia in Mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 8132-48. PMID 27488634 DOI: 10.1523/Jneurosci.4428-15.2016  0.397
2016 Dirnagl U. Thomas Willis Lecture: Is Translational Stroke Research Broken, and if So, How Can We Fix It? Stroke; a Journal of Cerebral Circulation. PMID 27354221 DOI: 10.1161/Strokeaha.116.013244  0.325
2016 Chamorro Á, Dirnagl U, Urra X, Planas AM. Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation. The Lancet. Neurology. PMID 27180033 DOI: 10.1016/S1474-4422(16)00114-9  0.329
2016 Winek K, Engel O, Koduah P, Heimesaat MM, Fischer A, Bereswill S, Dames C, Kershaw O, Gruber AD, Curato C, Oyama N, Meisel C, Meisel A, Dirnagl U. Depletion of Cultivatable Gut Microbiota by Broad-Spectrum Antibiotic Pretreatment Worsens Outcome After Murine Stroke. Stroke; a Journal of Cerebral Circulation. PMID 27056982 DOI: 10.1161/Strokeaha.115.011800  0.306
2016 Winek K, Meisel A, Dirnagl U. Gut microbiota impact on stroke outcome: Fad or fact? Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 26945017 DOI: 10.1177/0271678X16636890  0.315
2015 Jadavji NM, Wieske F, Dirnagl U, Winter C. Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ-aminobutyric acid in brain tissue. Molecular Genetics and Metabolism Reports. 3: 1-4. PMID 26937386 DOI: 10.1016/J.Ymgmr.2015.02.001  0.631
2015 Leithner C, Füchtemeier M, Jorks D, Mueller S, Dirnagl U, Royl G. Infarct Volume Prediction by Early Magnetic Resonance Imaging in a Murine Stroke Model Depends on Ischemia Duration and Time of Imaging. Stroke; a Journal of Cerebral Circulation. PMID 26451016 DOI: 10.1161/Strokeaha.114.007832  0.329
2015 Llovera G, Hofmann K, Roth S, Salas-Pérdomo A, Ferrer-Ferrer M, Perego C, Zanier ER, Mamrak U, Rex A, Party H, Agin V, Fauchon C, Orset C, Haelewyn B, De Simoni MG, ... Dirnagl U, et al. Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia. Science Translational Medicine. 7: 299ra121. PMID 26246166 DOI: 10.1126/Scitranslmed.Aaa9853  0.357
2015 Lauritzen M, Dirnagl U. The Journal of Cerebral Blood Flow and Metabolism clinical, inaugural issue. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 26219599 DOI: 10.1038/Jcbfm.2015.187  0.308
2015 Römer C, Engel O, Winek K, Hochmeister S, Zhang T, Royl G, Klehmet J, Dirnagl U, Meisel C, Meisel A. Blocking stroke-induced immunodeficiency increases CNS antigen-specific autoreactivity but does not worsen functional outcome after experimental stroke. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 7777-94. PMID 25995466 DOI: 10.1523/Jneurosci.1532-14.2015  0.355
2015 Østergaard L, Dreier JP, Hadjikhani N, Jespersen SN, Dirnagl U, Dalkara T. Neurovascular coupling during cortical spreading depolarization and -depression. Stroke; a Journal of Cerebral Circulation. 46: 1392-401. PMID 25882051 DOI: 10.1161/Strokeaha.114.008077  0.403
2015 Jadavji NM, Farr TD, Lips J, Khalil AA, Boehm-Sturm P, Foddis M, Harms C, Füchtemeier M, Dirnagl U. Elevated levels of plasma homocysteine, deficiencies in dietary folic acid and uracil-DNA glycosylase impair learning in a mouse model of vascular cognitive impairment. Behavioural Brain Research. 283: 215-26. PMID 25655513 DOI: 10.1016/J.Bbr.2015.01.040  0.698
2015 Füchtemeier M, Brinckmann MP, Foddis M, Kunz A, Po C, Curato C, Dirnagl U, Farr TD. Vascular change and opposing effects of the angiotensin type 2 receptor in a mouse model of vascular cognitive impairment. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 35: 476-84. PMID 25492118 DOI: 10.1038/Jcbfm.2014.221  0.358
2015 Jadavji NM, Wieske F, Dirnagl U, Winter C. Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ-aminobutyric acid in brain tissue Molecular Genetics and Metabolism Reports. 3: 1-4. DOI: 10.1016/j.ymgmr.2015.02.001  0.592
2014 Springer J, Schust S, Peske K, Tschirner A, Rex A, Engel O, Scherbakov N, Meisel A, von Haehling S, Boschmann M, Anker SD, Dirnagl U, Doehner W. Catabolic signaling and muscle wasting after acute ischemic stroke in mice: indication for a stroke-specific sarcopenia. Stroke; a Journal of Cerebral Circulation. 45: 3675-83. PMID 25352483 DOI: 10.1161/Strokeaha.114.006258  0.307
2014 Dirnagl U. Modeling immunity and inflammation in stroke: can mice be trusted? Stroke; a Journal of Cerebral Circulation. 45: e177-8. PMID 25061077 DOI: 10.1161/Strokeaha.114.005640  0.321
2014 Zille M, Harhausen D, De Saint-Hubert M, Michel R, Reutelingsperger CP, Dirnagl U, Wunder A. A dual-labeled Annexin A5 is not suited for SPECT imaging of brain cell death in experimental murine stroke. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 34. PMID 24984896 DOI: 10.1038/Jcbfm.2014.115  0.313
2014 Yildirim F, Ji S, Kronenberg G, Barco A, Olivares R, Benito E, Dirnagl U, Gertz K, Endres M, Harms C, Meisel A. Histone acetylation and CREB binding protein are required for neuronal resistance against ischemic injury. Plos One. 9: e95465. PMID 24748101 DOI: 10.1371/Journal.Pone.0095465  0.336
2014 Schäbitz WR, Dirnagl U. Are we ready to translate T-cell transmigration in stroke? Stroke; a Journal of Cerebral Circulation. 45: 1610-1. PMID 24743434 DOI: 10.1161/Strokeaha.114.005294  0.348
2014 Dirnagl U, Endres M. Found in translation: preclinical stroke research predicts human pathophysiology, clinical phenotypes, and therapeutic outcomes. Stroke; a Journal of Cerebral Circulation. 45: 1510-8. PMID 24652307 DOI: 10.1161/Strokeaha.113.004075  0.338
2014 Stöber F, Baldauf K, Ziabreva I, Harhausen D, Zille M, Neubert J, Reymann KG, Scheich H, Dirnagl U, Schröder UH, Wunder A, Goldschmidt J. Single-cell resolution mapping of neuronal damage in acute focal cerebral ischemia using thallium autometallography. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 34: 144-52. PMID 24129748 DOI: 10.1038/Jcbfm.2013.177  0.377
2013 Scherbakov N, von Haehling S, Anker SD, Dirnagl U, Doehner W. Stroke induced Sarcopenia: muscle wasting and disability after stroke. International Journal of Cardiology. 170: 89-94. PMID 24231058 DOI: 10.1016/J.Ijcard.2013.10.031  0.311
2013 Baron JC, Macrae IM, Adams HP, Dirnagl U. ESC-BRAIN: experimental and clinical stroke research--do they connect?. Meeting report of the ESC-BRAIN joint symposium held in London and Shanghai in May 2013. Cerebrovascular Diseases (Basel, Switzerland). 36: 306-21. PMID 24192895 DOI: 10.1159/000355027  0.324
2013 Harhausen D, Sudmann V, Khojasteh U, Müller J, Zille M, Graham K, Thiele A, Dyrks T, Dirnagl U, Wunder A. Specific imaging of inflammation with the 18 kDa translocator protein ligand DPA-714 in animal models of epilepsy and stroke. Plos One. 8: e69529. PMID 23936336 DOI: 10.1371/Journal.Pone.0069529  0.351
2013 Iadecola C, Dirnagl U. The microcircualtion--fantastic voyage: introduction. Stroke; a Journal of Cerebral Circulation. 44: S83. PMID 23709740 DOI: 10.1161/Strokeaha.112.680215  0.355
2013 Dirnagl U, Hakim A, Macleod M, Fisher M, Howells D, Alan SM, Steinberg G, Planas A, Boltze J, Savitz S, Iadecola C, Meairs S. A concerted appeal for international cooperation in preclinical stroke research. Stroke; a Journal of Cerebral Circulation. 44: 1754-60. PMID 23598526 DOI: 10.1161/Strokeaha.113.000734  0.385
2013 Knops M, Werner CG, Scherbakov N, Fiebach J, Dreier JP, Meisel A, Heuschmann PU, Jungehülsing GJ, von Haehling S, Dirnagl U, Anker SD, Doehner W. Investigation of changes in body composition, metabolic profile and skeletal muscle functional capacity in ischemic stroke patients: the rationale and design of the Body Size in Stroke Study (BoSSS). Journal of Cachexia, Sarcopenia and Muscle. 4: 199-207. PMID 23483531 DOI: 10.1007/S13539-013-0103-0  0.303
2013 Harms C, Datwyler AL, Wiekhorst F, Trahms L, Lindquist R, Schellenberger E, Mueller S, Schütz G, Roohi F, Ide A, Füchtemeier M, Gertz K, Kronenberg G, Harms U, Endres M, ... Dirnagl U, et al. Certain types of iron oxide nanoparticles are not suited to passively target inflammatory cells that infiltrate the brain in response to stroke. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 33: e1-9. PMID 23443176 DOI: 10.1038/Jcbfm.2013.22  0.313
2013 Dreier JP, Victorov IV, Petzold GC, Major S, Windmüller O, Fernández-Klett F, Kandasamy M, Dirnagl U, Priller J. Electrochemical failure of the brain cortex is more deleterious when it is accompanied by low perfusion. Stroke; a Journal of Cerebral Circulation. 44: 490-6. PMID 23287786 DOI: 10.1161/Strokeaha.112.660589  0.31
2013 Enzmann G, Mysiorek C, Gorina R, Cheng YJ, Ghavampour S, Hannocks MJ, Prinz V, Dirnagl U, Endres M, Prinz M, Beschorner R, Harter PN, Mittelbronn M, Engelhardt B, Sorokin L. The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury. Acta Neuropathologica. 125: 395-412. PMID 23269317 DOI: 10.1007/S00401-012-1076-3  0.397
2012 Dirnagl U. Pathobiology of injury after stroke: the neurovascular unit and beyond. Annals of the New York Academy of Sciences. 1268: 21-5. PMID 22994217 DOI: 10.1111/J.1749-6632.2012.06691.X  0.338
2012 Apostolova I, Wunder A, Dirnagl U, Michel R, Stemmer N, Lukas M, Derlin T, Gregor-Mamoudou B, Goldschmidt J, Brenner W, Buchert R. Brain perfusion SPECT in the mouse: normal pattern according to gender and age. Neuroimage. 63: 1807-17. PMID 22971548 DOI: 10.1016/J.Neuroimage.2012.08.038  0.319
2012 Lauritzen M, Dirnagl U. Celebrating the 30th anniversary of our journal. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 32: 1097. PMID 22569193 DOI: 10.1038/Jcbfm.2012.61  0.314
2012 Dirnagl U, Fisher M. REPRINT: International, multicenter randomized preclinical trials in translational stroke research: it is time to act. Stroke; a Journal of Cerebral Circulation. 43: 1453-4. PMID 22535274 DOI: 10.1161/Strokeaha.112.653709  0.373
2012 Dirnagl U, Fisher M. International, multicenter randomized preclinical trials in translational stroke research: it's time to act. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 32: 933-5. PMID 22510602 DOI: 10.1038/Jcbfm.2012.51  0.373
2012 Gertz K, Kronenberg G, Kälin RE, Baldinger T, Werner C, Balkaya M, Eom GD, Hellmann-Regen J, Kröber J, Miller KR, Lindauer U, Laufs U, Dirnagl U, Heppner FL, Endres M. Essential role of interleukin-6 in post-stroke angiogenesis. Brain : a Journal of Neurology. 135: 1964-80. PMID 22492561 DOI: 10.1093/Brain/Aws075  0.361
2012 Zille M, Farr TD, Przesdzing I, Müller J, Sommer C, Dirnagl U, Wunder A. Visualizing cell death in experimental focal cerebral ischemia: promises, problems, and perspectives. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 32: 213-31. PMID 22086195 DOI: 10.1038/Jcbfm.2011.150  0.323
2012 Haeusler KG, Schmidt WU, Foehring F, Meisel C, Guenther C, Brunecker P, Kunze C, Helms T, Dirnagl U, Volk HD, Villringer A. Immune responses after acute ischemic stroke or myocardial infarction. International Journal of Cardiology. 155: 372-7. PMID 21078527 DOI: 10.1016/J.Ijcard.2010.10.053  0.327
2011 Scherbakov N, Dirnagl U, Doehner W. Body weight after stroke: lessons from the obesity paradox. Stroke; a Journal of Cerebral Circulation. 42: 3646-50. PMID 21960580 DOI: 10.1161/Strokeaha.111.619163  0.303
2011 Mergenthaler P, Dirnagl U. Protective conditioning of the brain: expressway or roadblock? The Journal of Physiology. 589: 4147-55. PMID 21708907 DOI: 10.1113/Jphysiol.2011.209718  0.327
2011 Macrez R, Ali C, Toutirais O, Le Mauff B, Defer G, Dirnagl U, Vivien D. Stroke and the immune system: from pathophysiology to new therapeutic strategies. The Lancet. Neurology. 10: 471-80. PMID 21511199 DOI: 10.1016/S1474-4422(11)70066-7  0.317
2011 Engel O, Kolodziej S, Dirnagl U, Prinz V. Modeling stroke in mice - middle cerebral artery occlusion with the filament model. Journal of Visualized Experiments : Jove. PMID 21248698 DOI: 10.3791/2423  0.361
2011 Bahmani P, Schellenberger E, Klohs J, Steinbrink J, Cordell R, Zille M, Müller J, Harhausen D, Hofstra L, Reutelingsperger C, Farr TD, Dirnagl U, Wunder A. Visualization of cell death in mice with focal cerebral ischemia using fluorescent annexin A5, propidium iodide, and TUNEL staining. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: 1311-20. PMID 21245871 DOI: 10.1038/Jcbfm.2010.233  0.332
2011 Vesterinen HM, Vesterinen HV, Egan K, Deister A, Schlattmann P, Macleod MR, Dirnagl U. Systematic survey of the design, statistical analysis, and reporting of studies published in the 2008 volume of the Journal of Cerebral Blood Flow and Metabolism. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: 1064-72. PMID 21157472 DOI: 10.1038/Jcbfm.2010.217  0.302
2010 Kunz A, Dirnagl U, Mergenthaler P. Acute pathophysiological processes after ischaemic and traumatic brain injury. Best Practice & Research. Clinical Anaesthesiology. 24: 495-509. PMID 21619862 DOI: 10.1016/J.Bpa.2010.10.001  0.33
2010 Fernández-Klett F, Offenhauser N, Dirnagl U, Priller J, Lindauer U. Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain. Proceedings of the National Academy of Sciences of the United States of America. 107: 22290-5. PMID 21135230 DOI: 10.1073/Pnas.1011321108  0.351
2010 Macleod MR, Petersson J, Norrving B, Hacke W, Dirnagl U, Wagner M, Schwab S. Hypothermia for Stroke: call to action 2010. International Journal of Stroke : Official Journal of the International Stroke Society. 5: 489-92. PMID 21086713 DOI: 10.1111/J.1747-4949.2010.00520.X  0.32
2010 Lindauer U, Dirnagl U, Füchtemeier M, Böttiger C, Offenhauser N, Leithner C, Royl G. Pathophysiological interference with neurovascular coupling - when imaging based on hemoglobin might go blind. Frontiers in Neuroenergetics. 2. PMID 20953238 DOI: 10.3389/Fnene.2010.00025  0.349
2010 Leithner C, Müller S, Füchtemeier M, Lindauer U, Dirnagl U, Royl G. Determination of the brain-blood partition coefficient for water in mice using MRI. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 30: 1821-4. PMID 20842161 DOI: 10.1038/Jcbfm.2010.160  0.326
2010 Schlattmann P, Dirnagl U. Statistics in experimental cerebrovascular research: comparison of more than two groups with a continuous outcome variable. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 30: 1558-63. PMID 20571520 DOI: 10.1038/Jcbfm.2010.95  0.318
2010 Harhausen D, Prinz V, Ziegler G, Gertz K, Endres M, Lehrach H, Gasque P, Botto M, Stahel PF, Dirnagl U, Nietfeld W, Trendelenburg G. CD93/AA4.1: a novel regulator of inflammation in murine focal cerebral ischemia. Journal of Immunology (Baltimore, Md. : 1950). 184: 6407-17. PMID 20439917 DOI: 10.4049/Jimmunol.0902342  0.317
2010 Füchtemeier M, Leithner C, Offenhauser N, Foddis M, Kohl-Bareis M, Dirnagl U, Lindauer U, Royl G. Elevating intracranial pressure reverses the decrease in deoxygenated hemoglobin and abolishes the post-stimulus overshoot upon somatosensory activation in rats. Neuroimage. 52: 445-54. PMID 20420930 DOI: 10.1016/J.Neuroimage.2010.04.237  0.351
2010 Lindauer U, Leithner C, Kaasch H, Rohrer B, Foddis M, Füchtemeier M, Offenhauser N, Steinbrink J, Royl G, Kohl-Bareis M, Dirnagl U. Neurovascular coupling in rat brain operates independent of hemoglobin deoxygenation. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 30: 757-68. PMID 20040927 DOI: 10.1038/Jcbfm.2009.259  0.348
2010 Leithner C, Royl G, Offenhauser N, Füchtemeier M, Kohl-Bareis M, Villringer A, Dirnagl U, Lindauer U. Pharmacological uncoupling of activation induced increases in CBF and CMRO2. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 30: 311-22. PMID 19794398 DOI: 10.1038/Jcbfm.2009.211  0.345
2010 Dirnagl U. Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse Nature Precedings. 5: 1-1. DOI: 10.1038/Npre.2010.3492.2  0.317
2009 Ziegler G, Prinz V, Albrecht MW, Harhausen D, Khojasteh U, Nacken W, Endres M, Dirnagl U, Nietfeld W, Trendelenburg G. Mrp-8 and -14 mediate CNS injury in focal cerebral ischemia. Biochimica Et Biophysica Acta. 1792: 1198-204. PMID 19835955 DOI: 10.1016/J.Bbadis.2009.10.003  0.368
2009 Dirnagl U, Macleod MR. Stroke research at a road block: the streets from adversity should be paved with meta-analysis and good laboratory practice. British Journal of Pharmacology. 157: 1154-6. PMID 19664136 DOI: 10.1111/J.1476-5381.2009.00211.X  0.311
2009 Klohs J, Steinbrink J, Bourayou R, Mueller S, Cordell R, Licha K, Schirner M, Dirnagl U, Lindauer U, Wunder A. Near-infrared fluorescence imaging with fluorescently labeled albumin: a novel method for non-invasive optical imaging of blood-brain barrier impairment after focal cerebral ischemia in mice. Journal of Neuroscience Methods. 180: 126-32. PMID 19427539 DOI: 10.1016/J.Jneumeth.2009.03.002  0.341
2009 Dreier JP, Major S, Manning A, Woitzik J, Drenckhahn C, Steinbrink J, Tolias C, Oliveira-Ferreira AI, Fabricius M, Hartings JA, Vajkoczy P, Lauritzen M, Dirnagl U, Bohner G, Strong AJ, et al. Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage. Brain : a Journal of Neurology. 132: 1866-81. PMID 19420089 DOI: 10.1093/Brain/Awp102  0.341
2009 Royl G, Balkaya M, Lehmann S, Lehnardt S, Stohlmann K, Lindauer U, Endres M, Dirnagl U, Meisel A. Effects of the PDE5-inhibitor vardenafil in a mouse stroke model. Brain Research. 1265: 148-57. PMID 19368809 DOI: 10.1016/J.Brainres.2009.01.061  0.352
2009 Dirnagl U, Becker K, Meisel A. Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use. The Lancet. Neurology. 8: 398-412. PMID 19296922 DOI: 10.1016/S1474-4422(09)70054-7  0.332
2009 Macleod MR, Fisher M, O'Collins V, Sena ES, Dirnagl U, Bath PM, Buchan A, van der Worp HB, Traystman RJ, Minematsu K, Donnan GA, Howells DW. Reprint: Good laboratory practice: preventing introduction of bias at the bench. International Journal of Stroke : Official Journal of the International Stroke Society. 4: 3-5. PMID 19236488 DOI: 10.1111/J.1747-4949.2009.00241.X  0.334
2009 Macleod MR, Fisher M, O'Collins V, Sena ES, Dirnagl U, Bath PM, Buchan A, Buchan A, van der Worp HB, Traystman RJ, Minematsu K, Donnan GA, Howells DW. Reprint: Good laboratory practice: preventing introduction of bias at the bench. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 29: 221-3. PMID 18797473 DOI: 10.1038/Jcbfm.2008.101  0.333
2009 Endres M, Dirnagl U, Moskowitz MA. The ischemic cascade and mediators of ischemic injury. Handbook of Clinical Neurology. 92: 31-41. PMID 18790268 DOI: 10.1016/S0072-9752(08)01902-7  0.384
2009 Klehmet J, Harms H, Richter M, Prass K, Volk HD, Dirnagl U, Meisel A, Meisel C. Stroke-induced immunodepression and post-stroke infections: lessons from the preventive antibacterial therapy in stroke trial. Neuroscience. 158: 1184-93. PMID 18722511 DOI: 10.1016/J.Neuroscience.2008.07.044  0.314
2009 Macleod MR, Fisher M, O'Collins V, Sena ES, Dirnagl U, Bath PM, Buchan A, van der Worp HB, Traystman R, Minematsu K, Donnan GA, Howells DW. Good laboratory practice: preventing introduction of bias at the bench. Stroke; a Journal of Cerebral Circulation. 40: e50-2. PMID 18703798 DOI: 10.1161/Strokeaha.108.525386  0.334
2008 Klohs J, Gräfe M, Graf K, Steinbrink J, Dietrich T, Stibenz D, Bahmani P, Kronenberg G, Harms C, Endres M, Lindauer U, Greger K, Stelzer EH, Dirnagl U, Wunder A. In vivo imaging of the inflammatory receptor CD40 after cerebral ischemia using a fluorescent antibody. Stroke; a Journal of Cerebral Circulation. 39: 2845-52. PMID 18635859 DOI: 10.1161/Strokeaha.107.509844  0.326
2008 Harms H, Prass K, Meisel C, Klehmet J, Rogge W, Drenckhahn C, Göhler J, Bereswill S, Göbel U, Wernecke KD, Wolf T, Arnold G, Halle E, Volk HD, Dirnagl U, et al. Preventive antibacterial therapy in acute ischemic stroke: a randomized controlled trial. Plos One. 3: e2158. PMID 18478129 DOI: 10.1371/Journal.Pone.0002158  0.316
2008 Dirnagl U, Meisel A. Endogenous neuroprotection: mitochondria as gateways to cerebral preconditioning? Neuropharmacology. 55: 334-44. PMID 18402985 DOI: 10.1016/J.Neuropharm.2008.02.017  0.362
2008 Royl G, Füchtemeier M, Leithner C, Megow D, Offenhauser N, Steinbrink J, Kohl-Bareis M, Dirnagl U, Lindauer U. Hypothermia effects on neurovascular coupling and cerebral metabolic rate of oxygen. Neuroimage. 40: 1523-32. PMID 18343160 DOI: 10.1016/J.Neuroimage.2008.01.041  0.357
2008 Petzold GC, Haack S, von Bohlen Und Halbach O, Priller J, Lehmann TN, Heinemann U, Dirnagl U, Dreier JP. Nitric oxide modulates spreading depolarization threshold in the human and rodent cortex. Stroke; a Journal of Cerebral Circulation. 39: 1292-9. PMID 18309156 DOI: 10.1161/Strokeaha.107.500710  0.405
2008 Endres M, Engelhardt B, Koistinaho J, Lindvall O, Meairs S, Mohr JP, Planas A, Rothwell N, Schwaninger M, Schwab ME, Vivien D, Wieloch T, Dirnagl U. Improving outcome after stroke: overcoming the translational roadblock. Cerebrovascular Diseases (Basel, Switzerland). 25: 268-78. PMID 18292653 DOI: 10.1159/000118039  0.351
2008 Lopes MA, Meisel A, Dirnagl U, Carvalho FD, Bastos Mde L. Doxorubicin induces biphasic neurotoxicity to rat cortical neurons. Neurotoxicology. 29: 286-93. PMID 18258305 DOI: 10.1016/J.Neuro.2007.12.003  0.315
2008 Crossley NA, Sena E, Goehler J, Horn J, van der Worp B, Bath PM, Macleod M, Dirnagl U. Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach. Stroke; a Journal of Cerebral Circulation. 39: 929-34. PMID 18239164 DOI: 10.1161/Strokeaha.107.498725  0.308
2008 Leithner C, Gertz K, Schröck H, Priller J, Prass K, Steinbrink J, Villringer A, Endres M, Lindauer U, Dirnagl U, Royl G. A flow sensitive alternating inversion recovery (FAIR)-MRI protocol to measure hemispheric cerebral blood flow in a mouse stroke model. Experimental Neurology. 210: 118-27. PMID 18037417 DOI: 10.1016/J.Expneurol.2007.10.003  0.337
2008 Haeusler KG, Schmidt WU, Föhring F, Meisel C, Helms T, Jungehulsing GJ, Nolte CH, Schmolke K, Wegner B, Meisel A, Dirnagl U, Villringer A, Volk HD. Cellular immunodepression preceding infectious complications after acute ischemic stroke in humans. Cerebrovascular Diseases (Basel, Switzerland). 25: 50-8. PMID 18033958 DOI: 10.1159/000111499  0.34
2008 Prüss H, Prass K, Ghaeni L, Milosevic M, Muselmann C, Freyer D, Royl G, Reuter U, Baeva N, Dirnagl U, Meisel A, Priller J. Inducible nitric oxide synthase does not mediate brain damage after transient focal cerebral ischemia in mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 526-39. PMID 17851454 DOI: 10.1038/Sj.Jcbfm.9600550  0.368
2007 Kunte H, Schmidt S, Eliasziw M, del Zoppo GJ, Simard JM, Masuhr F, Weih M, Dirnagl U. Sulfonylureas improve outcome in patients with type 2 diabetes and acute ischemic stroke. Stroke; a Journal of Cerebral Circulation. 38: 2526-30. PMID 17673715 DOI: 10.1161/Strokeaha.107.482216  0.301
2007 Braun JS, Prass K, Dirnagl U, Meisel A, Meisel C. Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH. Experimental Neurology. 206: 183-91. PMID 17585906 DOI: 10.1016/J.Expneurol.2007.03.032  0.349
2007 Ruscher K, Rzeczinski S, Thein E, Freyer D, Victorov IV, Lam TT, Dirnagl U. Neuroprotective effects of the beta-carboline abecarnil studied in cultured cortical neurons and organotypic retinal cultures. Neuropharmacology. 52: 1488-95. PMID 17449066 DOI: 10.1016/J.Neuropharm.2007.02.006  0.305
2007 Dirnagl U, Klehmet J, Braun JS, Harms H, Meisel C, Ziemssen T, Prass K, Meisel A. Stroke-induced immunodepression: Experimental evidence and clinical relevance Stroke. 38: 770-773. PMID 17261736 DOI: 10.1161/01.Str.0000251441.89665.Bc  0.349
2007 Dreier JP, Kleeberg J, Alam M, Major S, Kohl-Bareis M, Petzold GC, Victorov I, Dirnagl U, Obrenovitch TP, Priller J. Endothelin-1-induced spreading depression in rats is associated with a microarea of selective neuronal necrosis Experimental Biology and Medicine. 232: 204-213. PMID 17259327 DOI: 10.3181/00379727-207-2320204  0.303
2007 Prass K, Royl G, Lindauer U, Freyer D, Megow D, Dirnagl U, Stöckler-Ipsiroglu G, Wallimann T, Priller J. Improved reperfusion and neuroprotection by creatine in a mouse model of stroke Journal of Cerebral Blood Flow and Metabolism. 27: 452-459. PMID 16773141 DOI: 10.1038/Sj.Jcbfm.9600351  0.418
2006 Gertz K, Priller J, Kronenberg G, Fink KB, Winter B, Schröck H, Ji S, Milosevic M, Harms C, Böhm M, Dirnagl U, Laufs U, Endres M. Physical activity improves long-term stroke outcome via endothelial nitric oxide synthase-dependent augmentation of neovascularization and cerebral blood flow Circulation Research. 99: 1132-1140. PMID 17038638 DOI: 10.1161/01.Res.0000250175.14861.77  0.375
2006 Royl G, Leithner C, Sellien H, Müller JP, Megow D, Offenhauser N, Steinbrink J, Kohl-Bareis M, Dirnagl U, Lindauer U. Functional imaging with laser speckle contrast analysis: vascular compartment analysis and correlation with laser Doppler flowmetry and somatosensory evoked potentials. Brain Research. 1121: 95-103. PMID 17030028 DOI: 10.1016/J.Brainres.2006.08.125  0.305
2006 Stroh A, Zimmer C, Werner N, Gertz K, Weir K, Kronenberg G, Steinbrink J, Mueller S, Sieland K, Dirnagl U, Nickenig G, Endres M. Tracking of systemically administered mononuclear cells in the ischemic brain by high-field magnetic resonance imaging Neuroimage. 33: 886-897. PMID 16973381 DOI: 10.1016/J.Neuroimage.2006.07.009  0.357
2006 Prass K, Braun JS, Dirnagl U, Meisel C, Meisel A. Stroke propagates bacterial aspiration to pneumonia in a model of cerebral ischemia Stroke. 37: 2607-2612. PMID 16946159 DOI: 10.1161/01.Str.0000240409.68739.2B  0.349
2006 Scheckenbach KEL, Dreier JP, Dirnagl U, Lindauer U. Impaired cerebrovascular reactivity after cortical spreading depression in rats: Restoration by nitric oxide or cGMP Experimental Neurology. 202: 449-455. PMID 16920100 DOI: 10.1016/J.Expneurol.2006.07.007  0.336
2006 Meairs S, Wahlgren N, Dirnagl U, Lindvall O, Rothwell P, Baron JC, Hossmann K, Engelhardt B, Ferro J, McCulloch J, Kaste M, Endres M, Koistinaho J, Planas A, Vivien D, et al. Stroke research priorities for the next decade--A representative view of the European scientific community. Cerebrovascular Diseases (Basel, Switzerland). 22: 75-82. PMID 16790993 DOI: 10.1159/000093098  0.314
2006 Dirnagl U. Bench to bedside: The quest for quality in experimental stroke research Journal of Cerebral Blood Flow and Metabolism. 26: 1465-1478. PMID 16525413 DOI: 10.1038/Sj.Jcbfm.9600298  0.321
2006 Meisel A, Prass K, Wolf T, Dirnagl U. Pathophysiology of Stroke Reviews in Cell Biology and Molecular Medicine. DOI: 10.1007/s004150200098  0.39
2005 Windmüller O, Lindauer U, Foddis M, Einhäupl KM, Dirnagl U, Heinemann U, Dreier JP. Ion changes in spreading ischaemia induce rat middle cerebral artery constriction in the absence of NO. Brain : a Journal of Neurology. 128: 2042-51. PMID 15901647 DOI: 10.1093/Brain/Awh545  0.323
2005 Petzold GC, Windmüller O, Haack S, Major S, Buchheim K, Megow D, Gabriel S, Lehmann TN, Drenckhahn C, Peters O, Meierkord H, Heinemann U, Dirnagl U, Dreier JP. Increased extracellular K+ concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression-like depolarizations and spreading ischemia. Stroke; a Journal of Cerebral Circulation. 36: 1270-7. PMID 15879337 DOI: 10.1161/01.Str.0000166023.51307.E0  0.308
2005 Nedergaard M, Dirnagl U. Role of glial cells in cerebral ischemia. Glia. 50: 281-6. PMID 15846807 DOI: 10.1002/Glia.20205  0.366
2005 Trendelenburg G, Dirnagl U. Neuroprotective role of astrocytes in cerebral ischemia: Focus on ischemic preconditioning Glia. 50: 307-320. PMID 15846804 DOI: 10.1002/Glia.20204  0.383
2005 Bösel J, Gandor F, Harms C, Synowitz M, Harms U, Djoufack PC, Megow D, Dirnagl U, Hörtnagl H, Fink KB, Endres M. Neuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neurones Journal of Neurochemistry. 92: 1386-1398. PMID 15748157 DOI: 10.1111/J.1471-4159.2004.02980.X  0.309
2005 Li J, Culman J, Hörtnagl H, Zhao Y, Gerova N, Timm M, Blume A, Zimmermann M, Seidel K, Dirnagl U, Unger T. Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury Faseb Journal. 19: 617-619. PMID 15665034 DOI: 10.1096/Fj.04-2960Fje  0.351
2005 Leithner C, Sellien H, Rohrer B, Royl G, Megow D, Steinbrink J, Kohl-Bareis M, Dirnagl U, Lindauer U. Allosteric release of nitric oxide from hemoglobin does not mediate neurovascular coupling Journal of Cerebral Blood Flow & Metabolism. 25: S207-S207. DOI: 10.1038/Sj.Jcbfm.9591524.0207  0.325
2005 Royl G, Prass K, Lindauer U, Megow D, Dirnagl U, Priller J. Neuroprotective effects of creatine in a mouse model of stroke: an experimental MRI study Journal of Cerebral Blood Flow and Metabolism. 25. DOI: 10.1038/Sj.Jcbfm.9591524.0006  0.399
2004 Dreier JP, Tille K, Dirnagl U. Partial antagonistic effect of adenosine on inverse coupling between spreading neuronal activation and cerebral blood flow in rats Neurocritical Care. 1: 85-94. PMID 16174901 DOI: 10.1385/Ncc:1:1:85  0.338
2004 Mergenthaler P, Dirnagl U, Meisel A. Pathophysiology of stroke: Lessons from animal models Metabolic Brain Disease. 19: 151-167. PMID 15554412 DOI: 10.1023/B:Mebr.0000043966.46964.E6  0.39
2004 Endres M, Biniszkiewicz D, Sobol RW, Harms C, Ahmadi M, Lipski A, Katchanov J, Mergenthaler P, Dirnagl U, Wilson SH, Meisel A, Jaenisch R. Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase. The Journal of Clinical Investigation. 113: 1711-21. PMID 15199406 DOI: 10.1172/Jci20926  0.352
2004 Seitz I, Dirnagl U, Lindauer U. Impaired Vascular Reactivity of Isolated Rat Middle Cerebral Artery after Cortical Spreading Depression in Vivo Journal of Cerebral Blood Flow and Metabolism. 24: 526-530. PMID 15129184 DOI: 10.1097/00004647-200405000-00006  0.317
2004 Meisel C, Prass K, Braun J, Victorov I, Wolf T, Megow D, Halle E, Volk HD, Dirnagl U, Meisel A. Preventive Antibacterial Treatment Improves the General Medical and Neurological Outcome in A Mouse Model of Stroke Stroke. 35: 2-6. PMID 14684767 DOI: 10.1161/01.Str.0000109041.89959.4C  0.318
2004 Winter B, Bert B, Fink H, Dirnagl U, Endres M. Dysexecutive Syndrome after Mild Cerebral Ischemia? Mice Learn Normally but Have Deficits in Strategy Switching Stroke. 35: 191-195. PMID 14671235 DOI: 10.1161/01.Str.0000107188.29688.2C  0.322
2003 Katchanov J, Waeber C, Gertz K, Gietz A, Winter B, Brück W, Dirnagl U, Veh RW, Endres M. Selective Neuronal Vulnerability Following Mild Focal Brain Ischemia in the Mouse Brain Pathology. 13: 452-464. PMID 14655751 DOI: 10.1111/J.1750-3639.2003.Tb00476.X  0.328
2003 Petzold GC, Einhäupl KM, Dirnagl U, Dreier JP. Ischemia Triggered by Spreading Neuronal Activation Is Induced by Endothelin-1 and Hemoglobin in the Subarachnoid Space Annals of Neurology. 54: 591-598. PMID 14595648 DOI: 10.1002/Ana.10723  0.38
2003 Endres M, Gertz K, Lindauer U, Katchanov J, Schultze J, Schröck H, Nickenig G, Kuschinsky W, Dirnagl U, Laufs U. Mechanisms of stroke protection by physical activity. Annals of Neurology. 54: 582-90. PMID 14595647 DOI: 10.1002/Ana.10722  0.362
2003 Prass K, Meisel C, Höflich C, Braun J, Halle E, Wolf T, Ruscher K, Victorov IV, Priller J, Dirnagl U, Volk HD, Meisel A. Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell Type 1-like immunostimulation Journal of Experimental Medicine. 198: 725-736. PMID 12939340 DOI: 10.1084/Jem.20021098  0.339
2003 Prass K, Scharff A, Ruscher K, Löwl D, Muselmann C, Victorov I, Kapinya K, Dirnagl U, Meisel A. Hypoxia-induced stroke tolerance in the mouse is mediated by erythropoietin. Stroke; a Journal of Cerebral Circulation. 34: 1981-6. PMID 12829864 DOI: 10.1161/01.Str.0000080381.76409.B2  0.318
2003 Lindauer U, Gethmann J, Kühl M, Kohl-Bareis M, Dirnagl U. Neuronal activity-induced changes of local cerebral microvascular blood oxygenation in the rat: Effect of systemic hyperoxia or hypoxia Brain Research. 975: 135-140. PMID 12763601 DOI: 10.1016/S0006-8993(03)02602-7  0.316
2003 Dirnagl U, Simon RP, Hallenbeck JM. Ischemic tolerance and endogenous neuroprotection Trends in Neurosciences. 26: 248-254. PMID 12744841 DOI: 10.1016/S0166-2236(03)00071-7  0.369
2003 Kapinya KJ, Harms U, Harms C, Blei K, Katchanov J, Dirnagl U, Hörtnagl H. Role of NAD(P)H:quinone oxidoreductase in the progression of neuronal cell death in vitro and following cerebral ischaemia in vivo Journal of Neurochemistry. 84: 1028-1039. PMID 12603827 DOI: 10.1046/J.1471-4159.2003.01601.X  0.329
2003 Gertz K, Laufs U, Lindauer U, Nickenig G, Böhm M, Dirnagl U, Endres M. Withdrawal of statin treatment abrogates stroke protection in mice Stroke. 34: 551-557. PMID 12574574 DOI: 10.1161/01.Str.0000054055.28435.Bf  0.318
2002 Endres M, Dirnagl U. Ischemia and stroke Advances in Experimental Medicine and Biology. 513: 455-473. PMID 12575832 DOI: 10.1007/978-1-4615-0123-7_17  0.368
2002 Ruscher K, Freyer D, Karsch M, Isaev N, Megow D, Sawitzki B, Priller J, Dirnagl U, Meisel A. Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: Evidence from an in vitro model Journal of Neuroscience. 22: 10291-10301. PMID 12451129 DOI: 10.1523/Jneurosci.22-23-10291.2002  0.334
2002 Dreier JP, Windmüller O, Petzold G, Lindauer U, Einhäupl KM, Dirnagl U, Loch Macdonald R, Dempsey RJ, Selman WR, Mocco J, Connolly ES. Ischemia triggered by red blood cell products in the subarachnoid space is inhibited by nimodipine administration or moderate volume expansion/hemodilution in rats Neurosurgery. 51: 1457-1467. PMID 12445352 DOI: 10.1227/01.Neu.0000309123.22032.55  0.336
2002 Kapinya KJ, Prass K, Dirnagl U. Isoflurane induced prolonged protection against cerebral ischemia in mice: A redox sensitive mechanism? Neuroreport. 13: 1431-1435. PMID 12167768 DOI: 10.1097/00001756-200208070-00017  0.371
2002 Kapinya KJ, Löwl D, Fütterer C, Maurer M, Waschke KF, Isaev NK, Dirnagl U. Tolerance against ischemic neuronal injury can be induced by volatile anesthetics and is inducible NO synthase dependent Stroke. 33: 1889-1898. PMID 12105371 DOI: 10.1161/01.Str.0000020092.41820.58  0.346
2002 Laufs U, Gertz K, Dirnagl U, Böhm M, Nickenig G, Endres M. Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice. Brain Research. 942: 23-30. PMID 12031849 DOI: 10.1016/S0006-8993(02)02649-5  0.361
2002 Prass K, Ruscher K, Karsch M, Isaev N, Megow D, Priller J, Scharff A, Dirnagl U, Meisel A. Desferrioxamine induces delayed tolerance against cerebral ischemia in vivo and in vitro. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 22: 520-5. PMID 11973424 DOI: 10.1097/00004647-200205000-00003  0.339
2002 Dreier JP, Kleeberg J, Petzold G, Priller J, Windmüller O, Orzechowski HD, Lindauer U, Heinemann U, Einhäupl KM, Dirnagl U. Endothelin-1 potently induces Leão's cortical spreading depression in vivo in the rat: a model for an endothelial trigger of migrainous aura? Brain : a Journal of Neurology. 125: 102-12. PMID 11834596 DOI: 10.1093/Brain/Awf007  0.336
2002 Trendelenburg G, Prass K, Priller J, Kapinya K, Polley A, Muselmann C, Ruscher K, Kannbley U, Schmitt AO, Castell S, Wiegand F, Meisel A, Rosenthal A, Dirnagl U. Serial analysis of gene expression identifies metallothionein-II as major neuroprotective gene in mouse focal cerebral ischemia. The Journal of Neuroscience. 22: 5879-5888. DOI: 10.1523/Jneurosci.22-14-05879.2002  0.318
2001 Endres M, Fan G, Meisel A, Dirnagl U, Jaenisch R. Effects of cerebral ischemia in mice lacking DNA methyltransferase 1 in post-mitotic neurons. Neuroreport. 12: 3763-6. PMID 11726790 DOI: 10.1097/00001756-200112040-00032  0.373
2001 Lindauer U, Royl G, Leithner C, Kühl M, Gold L, Gethmann J, Kohl-Bareis M, Villringer A, Dirnagl U. No evidence for early decrease in blood oxygenation in rat whisker cortex in response to functional activation. Neuroimage. 13: 988-1001. PMID 11352605 DOI: 10.1006/Nimg.2000.0709  0.333
2001 Bechmann I, Kwidzinski E, Kovac AD, Simbürger E, Horvath T, Gimsa U, Dirnagl U, Priller J, Nitsch R. Turnover of rat brain perivascular cells. Experimental Neurology. 168: 242-9. PMID 11259112 DOI: 10.1006/Exnr.2000.7618  0.301
2001 Dreier JP, Petzold G, Tille K, Lindauer U, Arnold G, Heinemann U, Einhäupl KM, Dirnagl U. Ischaemia triggered by spreading neuronal activation is inhibited by vasodilators in rats. The Journal of Physiology. 531: 515-26. PMID 11230523 DOI: 10.1111/J.1469-7793.2001.0515I.X  0.336
2001 Abdelkarim GE, Gertz K, Harms C, Katchanov J, Dirnagl U, Szabo C, Endres M. Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke. International Journal of Molecular Medicine. 7: 255-260. DOI: 10.3892/Ijmm.7.3.255  0.363
2001 Katchanov J, Harms C, Gertz K, Hauck L, Waeber C, Hirt L, Priller J, Harsdorf Rv, Brück W, Hörtnagl H, Dirnagl U, Bhide PG, Endres M. Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death. The Journal of Neuroscience. 21: 5045-5053. DOI: 10.1523/Jneurosci.21-14-05045.2001  0.306
2001 Weih M, Amberger N, Wegener S, Dirnagl U, Reuter T, Einhäupl K. Sulfonylurea Drugs Do Not Influence Initial Stroke Severity and In-Hospital Outcome in Stroke Patients With Diabetes Stroke. 32: 2029-2032. DOI: 10.1161/Str.32.9.2029  0.312
2000 Lyons SA, Pastor A, Ohlemeyer C, Kann O, Wiegand F, Prass K, Knapp F, Kettenmann H, Dirnagl U. Distinct physiologic properties of microglia and blood-borne cells in rat brain slices after permanent middle cerebral artery occlusion. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 20: 1537-49. PMID 11083228 DOI: 10.1097/00004647-200011000-00003  0.336
2000 Laufs U, Gertz K, Huang P, Nickenig G, Böhm M, Dirnagl U, Endres M. Atorvastatin Upregulates Type III Nitric Oxide Synthase in Thrombocytes, Decreases Platelet Activation, and Protects From Cerebral Ischemia in Normocholesterolemic Mice Stroke. 31: 2442-2449. PMID 11022078 DOI: 10.1161/01.Str.31.10.2442  0.367
2000 Dreier JP, Ebert N, Priller J, Megow D, Lindauer U, Klee R, Reuter U, Imai Y, Einhäupl KM, Victorov I, Dirnagl U. Products of hemolysis in the subarachnoid space inducing spreading ischemia in the cortex and focal necrosis in rats: a model for delayed ischemic neurological deficits after subarachnoid hemorrhage? Journal of Neurosurgery. 93: 658-666. PMID 11014545 DOI: 10.3171/Jns.2000.93.4.0658  0.378
2000 Prass K, Wiegand F, Schumann P, Ahrens M, Kapinya K, Harms C, Liao W, Trendelenburg G, Gertz K, Moskowitz MA, Knapp F, Victorov IV, Megow D, Dirnagl U. Hyperbaric oxygenation induced tolerance against focal cerebral ischemia in mice is strain dependent. Brain Research. 871: 146-150. PMID 10882793 DOI: 10.1016/S0006-8993(00)02264-2  0.347
2000 Angstwurm K, Reuss S, Freyer D, Arnold G, Dirnagl U, Schumann RR, Weber JR. Induced hypothermia in experimental pneumococcal meningitis. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 20: 834-8. PMID 10826534 DOI: 10.1097/00004647-200005000-00010  0.333
2000 Endres M, Meisel A, Biniszkiewicz D, Namura S, Prass K, Ruscher K, Lipski A, Jaenisch R, Moskowitz MA, Dirnagl U. DNA methyltransferase contributes to delayed ischemic brain injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 3175-81. PMID 10777781 DOI: 10.1523/Jneurosci.20-09-03175.2000  0.344
2000 Harms H, Wiegand F, Megow D, Prass K, Einhäupl KM, Dirnagl U. Acute treatment of hypertension increases infarct sizes in spontaneously hypertensive rats. Neuroreport. 11: 355-359. PMID 10674486 DOI: 10.1097/00001756-200002070-00027  0.343
2000 Weih M, Bergk A, Isaev NK, Ruscher K, Megow D, Riepe M, Meisel A, Victorov IV, Dirnagl U. Erratum to “Induction of ischemic tolerance in rat cortical neurons by 3-nitropropionic acid: chemical preconditioning” [Neurosci. Lett. 272 (1999) 207–210] ☆ Neuroscience Letters. 278: 194. DOI: 10.1016/S0304-3940(99)00974-X  0.303
1999 Weih M, Kallenberg K, Bergk A, Dirnagl U, Harms L, Wernecke KD, Einhäupl KM. Attenuated stroke severity after prodromal TIA: a role for ischemic tolerance in the brain? Stroke. 30: 1851-1854. PMID 10471435 DOI: 10.1161/01.Str.30.9.1851  0.349
1999 Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of ischaemic stroke: an integrated view. Trends in Neurosciences. 22: 391-7. PMID 10441299 DOI: 10.1016/S0166-2236(99)01401-0  0.365
1999 Dirnagl U, Villringer A. Cerebral Blood Flow and Hemoglobin Oxygenation Changes in Stroke : Fingerprinting with Near Infrared Spectroscopy and MRI The Keio Journal of Medicine. 48. DOI: 10.2302/Kjm.48.Supplement2_A76  0.337
1998 Angstwurm K, Freyer D, Dirnagl U, Hanisch UK, Schumann RR, Einhäupl KM, Weber JR. Tumour necrosis factor alpha induces only minor inflammatory changes in the central nervous system, but augments experimental meningitis. Neuroscience. 86: 627-34. PMID 9881875 DOI: 10.1016/S0306-4522(98)00032-3  0.301
1998 Ruscher K, Isaev N, Trendelenburg G, Weih M, Iurato L, Meisel A, Dirnagl U. Induction of hypoxia inducible factor 1 by oxygen glucose deprivation is attenuated by hypoxic preconditioning in rat cultured neurons Neuroscience Letters. 254: 117-120. PMID 9779934 DOI: 10.1016/S0304-3940(98)00688-0  0.303
1998 Turski L, Huth A, Sheardown M, McDonald F, Neuhaus R, Schneider HH, Dirnagl U, Wiegand F, Jacobsen P, Ottow E. ZK200775: a phosphonate quinoxalinedione AMPA antagonist for neuroprotection in stroke and trauma. Proceedings of the National Academy of Sciences of the United States of America. 95: 10960-10965. PMID 9724812 DOI: 10.1073/Pnas.95.18.10960  0.344
1998 Weih MK, Weikert S, Freyer D, Dirnagl U. Chemiluminescence detection of nitric oxide production from rat cerebral cortical endothelial cells in culture. Brain Research Protocols. 2: 175-182. PMID 9507111 DOI: 10.1016/S1385-299X(97)00037-8  0.315
1998 Peters O, Back T, Lindauer U, Busch C, Megow D, Dreier J, Dirnagl U. Increased formation of reactive oxygen species after permanent and reversible middle cerebral artery occlusion in the rat Journal of Cerebral Blood Flow and Metabolism. 18: 196-205. PMID 9469163 DOI: 10.1097/00004647-199802000-00011  0.338
1997 Malonek D, Dirnagl U, Lindauer U, Yamada K, Kanno I, Grinvald A. Vascular imprints of neuronal activity: relationships between the dynamics of cortical blood flow, oxygenation, and volume changes following sensory stimulation. Proceedings of the National Academy of Sciences of the United States of America. 94: 14826-31. PMID 9405698 DOI: 10.1073/Pnas.94.26.14826  0.317
1997 Wolf T, Lindauer U, Reuter U, Back T, Villringer A, Einhäupl K, Dirnagl U. Noninvasive near infrared spectroscopy monitoring of regional cerebral blood oxygenation changes during peri-infarct depolarizations in focal cerebral ischemia in the rat. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 17: 950-4. PMID 9307608 DOI: 10.1097/00004647-199709000-00004  0.37
1997 Bruer U, Weih MK, Isaev NK, Meisel A, Ruscher K, Bergk A, Trendelenburg G, Wiegand F, Victorov IV, Dirnagl U. Induction of tolerance in rat cortical neurons: hypoxic preconditioning Febs Letters. 414: 117-121. PMID 9305743 DOI: 10.1016/S0014-5793(97)00954-X  0.329
1997 Hirth C, Obrig H, Valdueza J, Dirnagl U, Villringer A. Simultaneous assessment of cerebral oxygenation and hemodynamics during a motor task. A combined near infrared and transcranial Doppler sonography study. Advances in Experimental Medicine and Biology. 411: 461-9. PMID 9269463 DOI: 10.1007/978-1-4615-5865-1_59  0.301
1997 Wolf T, Lindauer U, Villringer A, Dirnagl U. Excessive oxygen or glucose supply does not alter the blood flow response to somatosensory stimulation or spreading depression in rats. Brain Research. 761: 290-9. PMID 9252028 DOI: 10.1016/S0006-8993(97)00354-5  0.308
1997 Dirnagl U. Metabolic Aspects of Neurovascular Coupling Advances in Experimental Medicine and Biology. 413: 155-159. PMID 9238496 DOI: 10.1007/978-1-4899-0056-2_17  0.305
1997 Barfod C, Akgören N, Fabricius M, Dirnagl U, Lauritzen M. Laser-Doppler measurements of concentration and velocity of moving blood cells in rat cerebral circulation Acta Physiologica Scandinavica. 160: 123-132. PMID 9208038 DOI: 10.1046/J.1365-201X.1997.00130.X  0.333
1997 Riepe MW, Esclaire F, Kasischke K, Schreiber S, Nakase H, Kempski O, Ludolph AC, Dirnagl U, Hugon J. Increased hypoxic tolerance by chemical inhibition of oxidative phosphorylation: "chemical preconditioning". Journal of Cerebral Blood Flow and Metabolism. 17: 257-264. PMID 9119898 DOI: 10.1097/00004647-199703000-00002  0.329
1997 Weikert S, Freyer D, Weih M, Isaev N, Busch C, Schultze J, Megow D, Dirnagl U. Rapid Ca2+-dependent NO-production from central nervous system cells in culture measured by NO-nitrite/ozone chemoluminescence. Brain Research. 748: 1-11. PMID 9067439 DOI: 10.1016/S0006-8993(96)01241-3  0.314
1997 Dirnagl U. Measurements of Microcirculatory Events in the Brain in Vivo Primer On Cerebrovascular Diseases. 133-136. DOI: 10.1016/B978-012743170-3.50038-8  0.319
1996 Weber JR, Angstwurm K, Bove GM, Bürger W, Einhäupl KM, Dirnagl U, Moskowitz MA. The trigeminal nerve and augmentation of regional cerebral blood flow during experimental bacterial meningitis. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 16: 1319-24. PMID 8898707 DOI: 10.1097/00004647-199611000-00029  0.302
1996 Wolf T, Lindauer U, Obrig H, Dreier J, Back T, Villringer A, Dirnagl U. Systemic nitric oxide synthase inhibition does not affect brain oxygenation during cortical spreading depression in rats: a noninvasive near-infrared spectroscopy and laser-Doppler flowmetry study. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 16: 1100-7. PMID 8898681 DOI: 10.1097/00004647-199611000-00003  0.334
1996 Lindauer U, Megow D, Schultze J, Weber JR, Dirnagl U. Nitric oxide synthase inhibition does not affect somatosensory evoked potentials in the rat. Neuroscience Letters. 216: 207-10. PMID 8897494 DOI: 10.1016/0304-3940(96)13044-5  0.313
1996 Obrig H, Wolf T, Döge C, Hülsing JJ, Dirnagl U, Villringer A. Cerebral oxygenation changes during motor and somatosensory stimulation in humans, as measured by near-infrared spectroscopy. Advances in Experimental Medicine and Biology. 388: 219-24. PMID 8798815 DOI: 10.1007/978-1-4613-0333-6_27  0.306
1996 Kleinschmidt A, Obrig H, Requardt M, Merboldt KD, Dirnagl U, Villringer A, Frahm J. Simultaneous recording of cerebral blood oxygenation changes during human brain activation by magnetic resonance imaging and near-infrared spectroscopy. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 16: 817-26. PMID 8784226 DOI: 10.1097/00004647-199609000-00006  0.305
1996 Hock C, Villringer K, Müller-Spahn F, Hofmann M, Schuh-Hofer S, Heekeren H, Wenzel R, Dirnagl U, Villringer A. Near infrared spectroscopy in the diagnosis of Alzheimer's disease. Annals of the New York Academy of Sciences. 777: 22-9. PMID 8624087 DOI: 10.1111/J.1749-6632.1996.Tb34397.X  0.338
1995 Weber JR, Angstwurm K, Bürger W, Einhäupl KM, Dirnagl U. Anti ICAM-1 (CD 54) monoclonal antibody reduces inflammatory changes in experimental bacterial meningitis. Journal of Neuroimmunology. 63: 63-8. PMID 8557826 DOI: 10.1016/0165-5728(95)00131-X  0.328
1995 Angstwurm K, Weber JR, Segert A, Bürger W, Weih M, Freyer D, Einhäupl KM, Dirnagl U. Fucoidin, a polysaccharide inhibiting leukocyte rolling, attenuates inflammatory responses in experimental pneumococcal meningitis in rats. Neuroscience Letters. 191: 1-4. PMID 7659273 DOI: 10.1016/0304-3940(95)11541-4  0.318
1995 Dirnagl U, Lindauer U, Them A, Schreiber S, Pfister HW, Koedel U, Reszka R, Freyer D, Villringer A. Global cerebral ischemia in the rat: online monitoring of oxygen free radical production using chemiluminescence in vivo. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 15: 929-40. PMID 7593353 DOI: 10.1038/Jcbfm.1995.118  0.353
1994 Villringer A, Planck J, Stodieck S, Botzel K, Schleinkofer L, Dirnagl U. Noninvasive assessment of cerebral hemodynamics and tissue oxygenation during activation of brain cell function in human adults using near infrared spectroscopy Advances in Experimental Medicine and Biology. 345: 559-565. PMID 8079758 DOI: 10.1007/978-1-4615-2468-7_74  0.331
1994 Villringer A, Them A, Lindauer U, Einhäupl K, Dirnagl U. Capillary perfusion of the rat brain cortex: An in vivo confocal microscopy study Circulation Research. 75: 55-62. PMID 8013082 DOI: 10.1161/01.Res.75.1.55  0.304
1993 Dirnagl U, Lindauer U, Villringer A. Role of nitric oxide in the coupling of cerebral blood flow to neuronal activation in rats Neuroscience Letters. 149: 43-46. PMID 8469377 DOI: 10.1016/0304-3940(93)90343-J  0.32
1993 Villringer A, Planck J, Hock C, Schleinkofer L, Dirnagl U. Near infrared spectroscopy (NIRS): A new tool to study hemodynamic changes during activation of brain function in human adults Neuroscience Letters. 154: 101-104. PMID 8361619 DOI: 10.1016/0304-3940(93)90181-J  0.326
1993 Dirnagl U. Chapter 4 Cerebral ischemia: the microcirculation as trigger and target Progress in Brain Research. 96: 49-65. PMID 8332748 DOI: 10.1016/S0079-6123(08)63258-6  0.38
1993 Haberl RL, Villringer A, Dirnagl U. Applicability of laser-Doppler flowmetry for cerebral blood flow monitoring in neurological intensive care Acta Neurochirurgica, Supplement. 59: 64-68. PMID 8310864 DOI: 10.1007/978-3-7091-9302-0_11  0.309
1993 Dirnagl U, Lindauer U, Them A, Pfister W, Einhäupl KM, Villringer A. Subsurface Microscopical visualization of brain tissue in vivo: Present, problems and prospects Micron. 24: 611-622. DOI: 10.1016/0968-4328(93)90039-4  0.313
1991 Dirnagl U, Villringer A, Gebhardt R, Haberl RL, Schmiedek P, Einhaupl KM. Three-dimensional reconstruction of the rat brain cortical microcirculation in vivo Journal of Cerebral Blood Flow and Metabolism. 11: 353-360. PMID 2016343 DOI: 10.1038/Jcbfm.1991.74  0.316
1991 Villringer A, Dirnagl U, Them A, Schürer L, Krombach F, Einhäupl KM. Imaging of leukocytes within the rat brain cortex in vivo Microvascular Research. 42: 305-315. PMID 1723482 DOI: 10.1016/0026-2862(91)90064-I  0.333
1990 Dirnagl U, Pulsinelli W. Autoregulation of cerebral blood flow in experimental focal brain ischemia. Journal of Cerebral Blood Flow and Metabolism. 10: 327-336. PMID 2329121 DOI: 10.1038/Jcbfm.1990.61  0.372
1990 Dirnagl U, Jacewicz M, Pulsinelli W. Nimodipine posttreatment does not increase blood flow in rats with focal cortical ischemia. Stroke. 21: 1357-1361. PMID 2204148 DOI: 10.1161/01.Str.21.9.1357  0.352
1990 Dirnagl U, Tanabe J, Pulsinelli W. Pre- and post-treatment with MK-801 but not pretreatment alone reduces neocortical damage after focal cerebral ischemia in the rat. Brain Research. 527: 62-68. PMID 2149295 DOI: 10.1016/0006-8993(90)91060-T  0.34
1990 Pfister HW, Koedel U, Dirnagl U, Haberl RL, Feiden W, Einhäupl KM. Superoxide dismutase inhibits brain oedema formation in experimental pneumococcal meningitis. Acta Neurochirurgica. 51: 378-380. PMID 2089945 DOI: 10.1007/978-3-7091-9115-6_127  0.306
1989 Dirnagl U, Kaplan B, Jacewicz M, Pulsinelli W. Continuous Measurement of Cerebral Cortical Blood Flow by Laser—Doppler Flowmetry in a Rat Stroke Model: Journal of Cerebral Blood Flow and Metabolism. 9: 589-596. PMID 2674168 DOI: 10.1038/Jcbfm.1989.84  0.351
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