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Rahul Palchaudhuri - Publications

Affiliations: 
2011 University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
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38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Srikanthan MA, Humbert O, Haworth KG, Ironside C, Rajawat YS, Blazar BR, Palchaudhuri R, Boitano AE, Cooke MP, Scadden DT, Kiem HP. Effective Multi-lineage Engraftment in a Mouse Model of Fanconi Anemia Using Non-genotoxic Antibody-Based Conditioning. Molecular Therapy. Methods & Clinical Development. 17: 455-464. PMID 32226796 DOI: 10.1016/J.Omtm.2020.02.001  0.359
2020 Hyzy SL, Palchaudhuri R, Proctor JL, Pearse BR, Sarma GN, Gillard GO, Saha A, Lamothe TL, Brooks ML, Hammond K, Bhat A, Clark N, McDonagh CF, Kiem H, Wagner JE, et al. Successful Allogeneic Hematopoietic Stem Cell Transplantation in Mice Mediated By Well-Tolerated Conditioning Regimens Based on CD45-Targeted Antibody Drug Conjugate: Implications for Haplo Transplantation Biology of Blood and Marrow Transplantation. 26: S160. DOI: 10.1016/J.Bbmt.2019.12.713  0.344
2020 Pearse BR, Proctor JL, McDonough SM, Panwar R, Sarma GN, Neale J, Kien L, Dushime J, Latimer K, Lamothe TL, Brooks ML, Palchaudhuri R, Li Q, Jain N, Knihtila R, et al. A Non-Genotoxic Anti-CD117 Antibody Drug Conjugate (ADC) Designed for Patient Conditioning Prior to Stem Cell Transplant and HSC-Based Gene Therapy Has a Broad Therapeutic Window across Species Biology of Blood and Marrow Transplantation. 26: S35-S36. DOI: 10.1016/J.Bbmt.2019.12.580  0.359
2020 Gillard GO, Proctor JL, Brooks ML, Lamothe TL, Hyzy SL, McDonough SM, Clark N, Palchaudhuri R, Bhat A, Sarma GN, Bhattarai PR, Sawant P, Pearse BR, McDonagh CF, Boitano AE, et al. A Novel Targeted Approach to Achieve Immune System Reset: CD45-Targeted Antibody Drug Conjugates Enable Autologous HSCT and Ameliorate Disease in Preclinical Autoimmune Disease Models Biology of Blood and Marrow Transplantation. 26: S307-S308. DOI: 10.1016/J.Bbmt.2019.12.407  0.324
2020 Uchida N, Tisdale JF, Donahue RE, Pearse BR, McDonough SM, Proctor JL, Krouse AE, Linde N, Bonifacino A, Panwar R, Sarma GN, Kien L, Latimer K, Dushime J, Hyzy SL, ... ... Palchaudhuri R, et al. A Single Dose of CD117 Antibody Drug Conjugate Enables Hematopoietic Stem Cell Based Gene Therapy in Nonhuman Primates Biology of Blood and Marrow Transplantation. 26: S6. DOI: 10.1016/J.Bbmt.2019.12.139  0.344
2020 Proctor JL, Gillard GO, Mikse O, Lanieri L, Lamothe TL, Brooks ML, Kien L, McDonough SM, Bhat A, Palchaudhuri R, Bhattarai Pr, Sarma GN, Jain N, McDonagh CF, Boitano AE, et al. A Single Dose of a Novel Anti-Human Short Half-Life Engineered CD45-Targeted Antibody-Drug Conjugate (ADC) Is Cytoreductive on Patient-Derived Tumors and Extends Survival Beyond Standards of Care in Multiple Pre-Clinical Models of Hematologic Malignancy Biology of Blood and Marrow Transplantation. 26. DOI: 10.1016/J.Bbmt.2019.12.021  0.38
2019 Czechowicz A, Palchaudhuri R, Scheck A, Hu Y, Hoggatt J, Saez B, Pang WW, Mansour MK, Tate TA, Chan YY, Walck E, Wernig G, Shizuru JA, Winau F, Scadden DT, et al. Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation. Nature Communications. 10: 617. PMID 30728354 DOI: 10.1038/S41467-018-08201-X  0.341
2019 Gillard GO, Proctor JL, Brooks ML, Lamothe TL, Hyzy SL, Mikse O, McDonough S, Palchaudhuri R, Bhat A, Sarma GN, Bhattarai P, Sawant P, Pearse BR, Mcdonough CF, Boitano AE, et al. A Novel Targeted Approach to Achieve Immune System Reset: CD45-Targeted Antibody Drug Conjugates Enable Autologous HSCT, Ameliorate Disease in Autoimmune Models, Potently Kill Human Immune Cells from Normal Donors and MS Patients, and Achieve Immune Depletion in Non-Human Primates (NHP) Blood. 134: 3208-3208. DOI: 10.1182/Blood-2019-130752  0.335
2019 Tisdale JF, Donahue RE, Uchida N, Pearse BR, McDonough SM, Proctor JL, Krouse A, Linde NS, Bonifacino AC, Panwar R, Sarma GN, Kien L, Latimer K, Dushime J, Hyzy SL, ... ... Palchaudhuri R, et al. A Single Dose of CD117 Antibody Drug Conjugate Enables Autologous Gene-Modified Hematopoietic Stem Cell Transplant (Gene Therapy) in Nonhuman Primates Blood. 134: 610-610. DOI: 10.1182/Blood-2019-125968  0.345
2019 Hyzy SL, Palchaudhuri R, Proctor JL, Pearse BR, Sarma GN, Adams HL, Aslanian S, Gillard GO, Lamothe TL, Burenkova O, Brooks M, Gabros AD, McDonagh CF, Boitano AE, Cooke MP. CD45-Targeted Antibody Drug Conjugate Plus Post Transplant Cytoxan Is Sufficient to Enable Allogeneic Bone Marrow Transplant in a Minor Mismatch Mouse Model Biology of Blood and Marrow Transplantation. 25. DOI: 10.1016/J.Bbmt.2018.12.775  0.309
2019 Proctor JL, Hyzy SL, Adams HL, Brooks M, Gabros AD, McDonough SM, Kien L, Aslanian S, Pearse BR, Palchaudhuri R, Li Q, Sarma GN, Ladwig D, Dushime J, Panwar R, et al. Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models Biology of Blood and Marrow Transplantation. 25: S100. DOI: 10.1016/J.Bbmt.2018.12.368  0.336
2019 Palchaudhuri R, Pearse BR, Proctor JL, Hyzy SL, Aslanian S, Bhat A, Gillard GO, McDonough SM, Sarma GN, Ladwig D, Li Q, Jain N, Panwar R, Sawant P, Dushime J, et al. Non-Genotoxic Conditioning Using Amanitin Antibody-Drug Conjugates Targeting CD45 Effectively Deplete Human and Non-Human Primate Hematopoietic Stem Cells and Immune Cells Biology of Blood and Marrow Transplantation. 25: S32. DOI: 10.1016/J.Bbmt.2018.12.104  0.354
2019 Pearse BR, McDonough SM, Proctor JL, Panwar R, Sarma GN, Kien L, Dushime J, Adams HL, Hyzy SL, Brooks M, Palchaudhuri R, Li Q, Sawant P, Lamothe TL, Jain N, et al. A CD117-Amanitin Antibody Drug Conjugate (ADC) Effectively Depletes Human and Non-Human Primate Hematopoietic Stem and Progenitor Cells (HSPCs): targeted Non-Genotoxic Conditioning for Bone Marrow Transplant Biology of Blood and Marrow Transplantation. 25: S29-S30. DOI: 10.1016/J.Bbmt.2018.12.101  0.35
2018 Palchaudhuri R, Hyzy SL, Proctor JL, Adams HL, Pearse BR, Sarma G, Aslanian S, Gillard G, Lamothe TL, Burenkova O, Brooks ML, Gabros AD, McDonagh CF, Boitano AE, Cooke MP. Antibody Drug Conjugates Targeted to CD45 or CD117 Enable Allogeneic Hematopoietic Stem Cell Transplantation in Animal Models Blood. 132: 3324-3324. DOI: 10.1182/Blood-2018-99-119432  0.309
2018 Palchaudhuri R, Pearse BR, Proctor JL, Hyzy SL, Aslanian S, McDonough SM, Sarma G, Brooks ML, Bhat A, Ladwig D, McShea MA, Kallen NM, Li Q, Panwar R, Dushime J, et al. Targeting CD45 with an Amanitin Antibody-Drug Conjugate Effectively Depletes Human HSCs and Immune Cells for Transplant Conditioning Blood. 132: 4526-4526. DOI: 10.1182/Blood-2018-99-117167  0.376
2018 Srikanthan M, Haworth KG, Ironside CM, Chen J, Hartigan AJ, Palchaudhuri R, Boitano AE, Cooke MP, Kiem H. Non-Genotoxic Conditioning Efficiently Depletes Host Hematopoietic Stem Cells and Facilitates Robust Multi-Lineage Engraftment in a Mouse Model of Fanconi Anemia Blood. 132: 2041-2041. DOI: 10.1182/Blood-2018-99-116851  0.369
2018 Pearse BR, McDonough SM, Proctor JL, Panwar R, Sarma G, McShea MA, Kien L, Dushime J, Adams HL, Hyzy SL, Brooks ML, Palchaudhuri R, Li Q, Kallen NM, Sawant P, et al. CD117-Amanitin Antibody Drug Conjugates Effectively Deplete Human and Non-Human Primate HSCs: Proof of Concept As a Targeted Strategy for Conditioning Patients for Bone Marrow Transplant Blood. 132: 3314-3314. DOI: 10.1182/Blood-2018-99-114881  0.355
2018 Proctor JL, Hyzy SL, Adams HL, Brooks ML, Gabros AD, McDonough SM, Kien L, Aslanian S, Pearse BR, Palchaudhuri R, Li Q, Kallen NM, Sarma G, McShea MA, Ladwig D, et al. Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models Blood. 132: 3316-3316. DOI: 10.1182/Blood-2018-99-112726  0.343
2017 Schiroli G, Ferrari S, Conway A, Jacob A, Capo V, Albano L, Plati T, Castiello MC, Sanvito F, Gennery AR, Bovolenta C, Palchaudhuri R, Scadden DT, Holmes MC, Villa A, et al. Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1. Science Translational Medicine. 9. PMID 29021165 DOI: 10.1126/Scitranslmed.Aan0820  0.311
2016 Palchaudhuri R, Saez B, Hoggatt J, Schajnovitz A, Sykes DB, Tate TA, Czechowicz A, Kfoury Y, Ruchika F, Rossi DJ, Verdine GL, Mansour MK, Scadden DT. Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin. Nature Biotechnology. PMID 27272386 DOI: 10.1038/Nbt.3584  0.369
2016 Czechowicz A, Palchaudhuri R, Scheck A, Hoggatt J, Saez B, Scadden DT, Rossi DJ. Completely Non-Myeloablative/Non-Lymphoablative Conditioning for BMT/HSCT Using Anti-Ckit Immunotoxins Blood. 128: 493-493. DOI: 10.1182/Blood.V128.22.493.493  0.354
2015 Palchaudhuri R, Lambrecht MJ, Botham RC, Partlow KC, van Ham TJ, Putt KS, Nguyen LT, Kim SH, Peterson RT, Fan TM, Hergenrother PJ. A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed. Cell Reports. 13: 2027-2036. PMID 26655912 DOI: 10.1016/J.Celrep.2015.10.042  0.736
2015 Palchaudhuri R, Saez B, Hoggatt J, Schajnovitz A, Sykes DB, Mansour MK, Scadden DT. Immunotoxin Enables Non-Genotoxic Conditioning for Hematopoietic Stem Cell Transplantation Blood. 126: 32-32. DOI: 10.1182/Blood.V126.23.32.32  0.363
2015 Palchaudhuri R, Lambrecht MJ, Botham RC, Partlow KC, vanHam TJ, Putt KS, Nguyen LT, Kim SH, Peterson RT, Fan TM, Hergenrother PJ. A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed Cell Reports. DOI: 10.1016/j.celrep.2015.10.042  0.728
2014 Saez B, Ferraro F, Yusuf RZ, Cook CM, Yu VW, Pardo-Saganta A, Sykes SM, Palchaudhuri R, Schajnovitz A, Lotinun S, Lymperi S, Mendez-Ferrer S, Toro RD, Day R, Vasic R, et al. Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning. Blood. 124: 2937-47. PMID 25202142 DOI: 10.1182/Blood-2014-08-593426  0.375
2013 Calvaresi EC, Granchi C, Tuccinardi T, Di Bussolo V, Huigens RW, Lee HY, Palchaudhuri R, Macchia M, Martinelli A, Minutolo F, Hergenrother PJ. Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor. Chembiochem : a European Journal of Chemical Biology. 14: 2263-7. PMID 24174263 DOI: 10.1002/Cbic.201300562  0.72
2012 West DC, Qin Y, Peterson QP, Thomas DL, Palchaudhuri R, Morrison KC, Lucas PW, Palmer AE, Fan TM, Hergenrother PJ. Differential effects of procaspase-3 activating compounds in the induction of cancer cell death. Molecular Pharmaceutics. 9: 1425-34. PMID 22486564 DOI: 10.1021/Mp200673N  0.735
2012 Saez B, Ferraro F, Yusuf RZ, Cook CM, Sykes SM, Pardo A, Yu VW, Lotinun S, Palchaudhuri R, Lee D, Lymperi S, Day R, Vasic R, Acharya SS, Baron R, et al. Hematopoietic Stem/Progenitor Cell Retention in the Bone Marrow Depends On Tissue Specific Heparan Sulfate Proteoglycans Blood. 120: 637-637. DOI: 10.1182/Blood.V120.21.637.637  0.345
2012 Yusuf RZ, Acharya SS, Yu VW, Saez B, Cobert JM, Doench J, Bullinger L, S'aulis D, Lee D, Palchaudhuri R, Uzosike AC, Duvet M, Logan DJ, Das S, Cook CM, et al. Aldehyde Dehydrogenase 3a2 (Aldh3a2) Represents a Distinct Metabolic Vulnerability in MLL-AF9 AML Leukemia Initiating Cells Blood. 120: 208-208. DOI: 10.1182/Blood.V120.21.208.208  0.4
2011 Risberg K, Guldvik IJ, Palchaudhuri R, Xi Y, Ju J, Fodstad O, Hergenrother PJ, Andersson Y. Triphenylmethyl derivatives enhances the anticancer effect of immunotoxins. Journal of Immunotherapy (Hagerstown, Md. : 1997). 34: 438-47. PMID 21577141 DOI: 10.1097/Cji.0B013E31821E00Ae  0.598
2011 Granchi C, Roy S, Giacomelli C, Macchia M, Tuccinardi T, Martinelli A, Lanza M, Betti L, Giannaccini G, Lucacchini A, Funel N, León LG, Giovannetti E, Peters GJ, Palchaudhuri R, et al. Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells. Journal of Medicinal Chemistry. 54: 1599-612. PMID 21332213 DOI: 10.1021/Jm101007Q  0.756
2011 Palchaudhuri R, Hergenrother PJ. Transcript profiling and RNA interference as tools to identify small molecule mechanisms and therapeutic potential. Acs Chemical Biology. 6: 21-33. PMID 21105689 DOI: 10.1021/Cb100310H  0.563
2011 Hoyt MT, Palchaudhuri R, Hergenrother PJ. Cribrostatin 6 induces death in cancer cells through a reactive oxygen species (ROS)-mediated mechanism. Investigational New Drugs. 29: 562-73. PMID 20169400 DOI: 10.1007/S10637-010-9390-X  0.732
2010 Bair JS, Palchaudhuri R, Hergenrother PJ. Chemistry and biology of deoxynyboquinone, a potent inducer of cancer cell death. Journal of the American Chemical Society. 132: 5469-78. PMID 20345134 DOI: 10.1021/Ja100610M  0.738
2010 Stefely JA, Palchaudhuri R, Miller PA, Peterson RJ, Moraski GC, Hergenrother PJ, Miller MJ. N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a new scaffold that provides rapid access to antimicrotubule agents: synthesis and evaluation of antiproliferative activity against select cancer cell lines. Journal of Medicinal Chemistry. 53: 3389-95. PMID 20334421 DOI: 10.1021/Jm1000979  0.607
2008 Palchaudhuri R, Hergenrother PJ. Triphenylmethylamides (TPMAs): Structure-activity relationship of compounds that induce apoptosis in melanoma cells. Bioorganic & Medicinal Chemistry Letters. 18: 5888-91. PMID 18710803 DOI: 10.1016/J.Bmcl.2008.07.128  0.64
2008 Palchaudhuri R, Nesterenko V, Hergenrother PJ. The complex role of the triphenylmethyl motif in anticancer compounds. Journal of the American Chemical Society. 130: 10274-81. PMID 18611022 DOI: 10.1021/Ja8020999  0.719
2007 Palchaudhuri R, Hergenrother PJ. DNA as a target for anticancer compounds: methods to determine the mode of binding and the mechanism of action. Current Opinion in Biotechnology. 18: 497-503. PMID 17988854 DOI: 10.1016/J.Copbio.2007.09.006  0.532
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