Maire F. Osborn, Ph.D.
Affiliations: | Chemistry and Biochemistry | University of Oregon, Eugene, OR, United States |
Area:
Bioinorganic Chemistry, Biophysical Chemistry & Chemical BiologyGoogle:
"Maire Osborn"Mean distance: 8.79 | S | N | B | C | P |
Parents
Sign in to add mentor| Victoria J. DeRose | grad student | 2014 | University of Oregon | |
| (Cellular RNA targeting by platinum (II) anticancer therapeutics.) | ||||
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Publications
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| Biscans A, Coles A, Haraszti R, et al. (2019) Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo. Nucleic Acids Research. 47: 1082-1096 |
| Osborn MF, Coles AH, Biscans A, et al. (2018) Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways. Nucleic Acids Research |
| Osborn MF, Khvorova A. (2018) Improving Small Interfering RNA Delivery In Vivo Through Lipid Conjugation. Nucleic Acid Therapeutics |
| Osborn MF, Coles AH, Golebiowski D, et al. (2018) Efficient gene silencing in brain tumors with hydrophobically modified siRNAs. Molecular Cancer Therapeutics |
| Hassler MR, Turanov AA, Alterman JF, et al. (2018) Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo. Nucleic Acids Research |
| Nikan M, Osborn MF, Coles AH, et al. (2017) Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable, O-phosphocholine-N-docosahexaenoyl-L-serine siRNA Conjugate in Mouse Brain. Bioconjugate Chemistry |
| Nikan M, Osborn MF, Coles AH, et al. (2016) Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain. Molecular Therapy. Nucleic Acids. 5: e344 |
| Coles AH, Osborn MF, Golebowski D, et al. (2016) Abstract PR12: Robust modulation of gene expression in aggressive glioblastoma mouse models: A new approach for in vivo target validation Cancer Research. 76 |
| Alterman JF, Hall LM, Coles AH, et al. (2015) Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain. Molecular Therapy. Nucleic Acids. 4: e266 |
| Coles AH, Osborn MF, Alterman JF, et al. (2015) A High-Throughput Method for Direct Detection of Therapeutic Oligonucleotide-Induced Gene Silencing In Vivo. Nucleic Acid Therapeutics |