Lauren E. Mays, Ph.D.
Affiliations: | University of Pennsylvania, Philadelphia, PA, United States |
Area:
Gene Therapy, Liver Disease, ImmunologyGoogle:
"Lauren Mays"Parents
Sign in to add mentorJames M. Wilson | grad student | 2010 | Penn | |
(The impact of capsid structure on the immune response to adeno-associated viral vectors.) |
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Publications
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Mikals K, Nam HJ, Van Vliet K, et al. (2014) The structure of AAVrh32.33, a novel gene delivery vector. Journal of Structural Biology. 186: 308-17 |
Mays LE, Wang L, Lin J, et al. (2014) AAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion, and minimal MHCI upregulation on target cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 28-41 |
Mays LE, Wang L, Tenney R, et al. (2013) Mapping the structural determinants responsible for enhanced T cell activation to the immunogenic adeno-associated virus capsid from isolate rhesus 32.33. Journal of Virology. 87: 9473-85 |
Mays LE, Wilson JM. (2011) The complex and evolving story of T cell activation to AAV vector-encoded transgene products. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 16-27 |
Mays LE, Wilson JM. (2009) Identification of the murine AAVrh32.33 capsid-specific CD8+ T cell epitopes. The Journal of Gene Medicine. 11: 1095-102 |
Gao G, Wang Q, Calcedo R, et al. (2009) Adeno-associated virus-mediated gene transfer to nonhuman primate liver can elicit destructive transgene-specific T cell responses. Human Gene Therapy. 20: 930-42 |
Mays LE, Vandenberghe LH, Xiao R, et al. (2009) Adeno-associated virus capsid structure drives CD4-dependent CD8+ T cell response to vector encoded proteins. Journal of Immunology (Baltimore, Md. : 1950). 182: 6051-60 |
Mays LE, Chen YH. (2007) Maintaining immunological tolerance with Foxp3. Cell Research. 17: 904-18 |
Lin J, Zhi Y, Mays L, et al. (2007) Vaccines based on novel adeno-associated virus vectors elicit aberrant CD8+ T-cell responses in mice. Journal of Virology. 81: 11840-9 |