Lauren E. Mays, Ph.D.

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
Gene Therapy, Liver Disease, Immunology
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"Lauren Mays"

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James  M. Wilson grad student 2010 Penn
 (The impact of capsid structure on the immune response to adeno-associated viral vectors.)
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Mikals K, Nam HJ, Van Vliet K, et al. (2014) The structure of AAVrh32.33, a novel gene delivery vector. Journal of Structural Biology. 186: 308-17
Mays LE, Wang L, Lin J, et al. (2014) AAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion, and minimal MHCI upregulation on target cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 28-41
Mays LE, Wang L, Tenney R, et al. (2013) Mapping the structural determinants responsible for enhanced T cell activation to the immunogenic adeno-associated virus capsid from isolate rhesus 32.33. Journal of Virology. 87: 9473-85
Mays LE, Wilson JM. (2011) The complex and evolving story of T cell activation to AAV vector-encoded transgene products. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 16-27
Mays LE, Wilson JM. (2009) Identification of the murine AAVrh32.33 capsid-specific CD8+ T cell epitopes. The Journal of Gene Medicine. 11: 1095-102
Mays LE, Vandenberghe LH, Xiao R, et al. (2009) Adeno-associated virus capsid structure drives CD4-dependent CD8+ T cell response to vector encoded proteins. Journal of Immunology (Baltimore, Md. : 1950). 182: 6051-60
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