Robert M. Kotin, PhD
Affiliations: | National Institutes of Health, Bethesda, MD |
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"Robert Kotin"
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Publications
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Destro F, Joseph J, Srinivasan P, et al. (2023) Mechanistic modeling explains the production dynamics of recombinant adeno-associated virus with the baculovirus expression vector system. Molecular Therapy. Methods & Clinical Development. 30: 122-146 |
Hildebrandt E, Penzes JJ, Gifford RJ, et al. (2020) Evolution of dependoparvoviruses across geological timescales-implications for design of AAV-based gene therapy vectors. Virus Evolution. 6: veaa043 |
Kotin RM, Wright JF. (2019) Recombinant Adeno-Associated Virus Quality Control for Non-Clinical and Clinical Vectors: How an Unregulated Commercial Sector Can Compromise Development of New Gene Therapies. Human Gene Therapy. 30: 1447-1448 |
Kotin RM, Snyder RO. (2017) Manufacturing clinical grade recombinant adeno-associated virus using invertebrate cell lines. Human Gene Therapy |
Smith RH, Hallwirth CV, Westerman M, et al. (2016) Germline viral "fossils" guide in silico reconstruction of a mid-Cenozoic era marsupial adeno-associated virus. Scientific Reports. 6: 28965 |
Choudhury SR, Fitzpatrick Z, Harris AF, et al. (2016) In vivo selection yields AAV-B1 capsid for CNS and muscle gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy |
Hallwirth CV, Smith RH, Westerman M, et al. (2016) 541. Use of Endogenous Viral Elements to Deduce the Sequence of an Ancient Adeno-Associated Virus That Circulated Amongst Australian Marsupials ~30 Million Years Ago Molecular Therapy. 24: S216 |
Le Guiner C, Montus M, Servais L, et al. (2014) Forelimb treatment in a large cohort of dystrophic dogs supports delivery of a recombinant AAV for exon skipping in Duchenne patients. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 1923-35 |
Li L, Dimitriadis EK, Yang Y, et al. (2013) Production and characterization of novel recombinant adeno-associated virus replicative-form genomes: a eukaryotic source of DNA for gene transfer. Plos One. 8: e69879 |
Airenne KJ, Hu YC, Kost TA, et al. (2013) Baculovirus: an insect-derived vector for diverse gene transfer applications. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 739-49 |