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Gabriel M. Simon, Ph.D. - Publications

Affiliations: 
2009 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Medicinal Chemistry
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41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Baltgalvis KA, Lamb KN, Symons KT, Wu CC, Hoffman MA, Snead AN, Song X, Glaza T, Kikuchi S, Green JC, Rogness DC, Lam B, Rodriguez-Aguirre ME, Woody DR, Eissler CL, ... ... Simon GM, et al. Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase. Nature. PMID 38658751 DOI: 10.1038/s41586-024-07318-y  0.648
2024 Liu Z, Remsberg JR, Li H, Njomen E, DeMeester KE, Tao Y, Xia G, Hayward RE, Yoo M, Nguyen T, Simon GM, Schreiber SL, Melillo B, Cravatt BF. Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders. Journal of the American Chemical Society. PMID 38569115 DOI: 10.1021/jacs.3c13448  0.489
2023 Li H, Ma T, Remsberg JR, Won SJ, DeMeester KE, Njomen E, Ogasawara D, Zhao KT, Huang TP, Lu B, Simon GM, Melillo B, Schreiber SL, Lykke-Andersen J, Liu DR, et al. Assigning functionality to cysteines by base editing of cancer dependency genes. Nature Chemical Biology. PMID 37783940 DOI: 10.1038/s41589-023-01428-w  0.525
2023 Lazear MR, Remsberg JR, Jaeger MG, Rothamel K, Her HL, DeMeester KE, Njomen E, Hogg SJ, Rahman J, Whitby LR, Won SJ, Schafroth MA, Ogasawara D, Yokoyama M, Lindsey GL, ... ... Simon GM, et al. Proteomic discovery of chemical probes that perturb protein complexes in human cells. Molecular Cell. PMID 37084731 DOI: 10.1016/j.molcel.2023.03.026  0.75
2022 Kavanagh ME, Horning BD, Khattri R, Roy N, Lu JP, Whitby LR, Ye E, Brannon JC, Parker A, Chick JM, Eissler CL, Wong AJ, Rodriguez JL, Rodiles S, Masuda K, ... ... Simon GM, et al. Author Correction: Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine. Nature Chemical Biology. PMID 36180594 DOI: 10.1038/s41589-022-01181-6  0.667
2022 Kavanagh ME, Horning BD, Khattri R, Roy N, Lu JP, Whitby LR, Ye E, Brannon JC, Parker A, Chick JM, Eissler CL, Wong AP, Rodriguez JL, Rodiles S, Masuda K, ... ... Simon GM, et al. Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine. Nature Chemical Biology. PMID 36097295 DOI: 10.1038/s41589-022-01098-0  0.687
2021 Zhang X, Luukkonen LM, Eissler CL, Crowley VM, Yamashita Y, Schafroth MA, Kikuchi S, Weinstein DS, Symons KT, Nordin BE, Rodriguez JL, Wucherpfennig TG, Bauer LG, Dix MM, Stamos D, ... ... Simon GM, et al. DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras. Journal of the American Chemical Society. PMID 33783207 DOI: 10.1021/jacs.1c00990  0.704
2020 László ZI, Lele Z, Zöldi M, Miczán V, Mógor F, Simon GM, Mackie K, Kacskovics I, Cravatt BF, Katona I. ABHD4-dependent developmental anoikis safeguards the embryonic brain. Nature Communications. 11: 4363. PMID 32868797 DOI: 10.1038/S41467-020-18175-4  0.485
2020 Vaisar T, Hu JH, Airhart N, Fox KA, Heinecke JW, Nicosia RF, Kohler TR, Potter ZE, Simon GM, Dix M, Cravatt B, Gharib SA, Dichek D. Parallel Murine and Human Plaque Proteomics Reveals Pathways of Plaque Rupture. Circulation Research. PMID 32762496 DOI: 10.1161/Circresaha.120.317295  0.692
2020 Vinogradova EV, Zhang X, Remillard D, Lazar DC, Suciu RM, Wang Y, Bianco G, Yamashita Y, Crowley VM, Schafroth MA, Yokoyama M, Konrad DB, Lum KM, Simon GM, Kemper EK, et al. An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. PMID 32730809 DOI: 10.1016/J.Cell.2020.07.001  0.728
2019 Chen AL, Lum KM, Lara-Gonzalez P, Ogasawara D, Cognetta AB, To A, Parsons WH, Simon GM, Desai A, Petrascheck M, Bar-Peled L, Cravatt BF. Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan. Nature Chemical Biology. PMID 30911178 DOI: 10.1038/S41589-019-0243-4  0.56
2018 Clapper JR, Henry CL, Niphakis MJ, Knize AM, Coppola AR, Simon GM, Ngo N, Herbst RA, Herbst DM, Reed AW, Cisar JS, Weber OD, Viader A, Alexander JP, Cunningham ML, et al. Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators. The Journal of Pharmacology and Experimental Therapeutics. PMID 30305428 DOI: 10.1124/Jpet.118.252296  0.334
2018 Cisar JS, Weber OD, Clapper JR, Blankman J, Henry CL, Simon GM, Alexander JP, Jones TK, Ezekowitz RAB, O'Neill GP, Grice CA. Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders. Journal of Medicinal Chemistry. PMID 30067909 DOI: 10.1021/Acs.Jmedchem.8B00951  0.336
2017 Whitby LR, Obach RS, Simon GM, Hayward MM, Cravatt BF. Quantitative Chemical Proteomic Profiling of the in Vivo Targets of Reactive Drug Metabolites. Acs Chemical Biology. PMID 28636309 DOI: 10.1021/Acschembio.7B00346  0.482
2015 Lee HC, Simon GM, Cravatt BF. ABHD4 regulates multiple classes of N-acyl phospholipids in the mammalian central nervous system. Biochemistry. 54: 2539-49. PMID 25853435 DOI: 10.1021/Acs.Biochem.5B00207  0.497
2014 Lysenko LV, Kim J, Henry C, Tyrtyshnaia A, Kohnz RA, Madamba F, Simon GM, Kleschevnikova NE, Nomura DK, Ezekowitz RA, Kleschevnikov AM. Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome. Plos One. 9: e114521. PMID 25474204 DOI: 10.1371/Journal.Pone.0114521  0.548
2014 Dix MM, Simon GM, Cravatt BF. Global identification of caspase substrates using PROTOMAP (protein topography and migration analysis platform). Methods in Molecular Biology (Clifton, N.J.). 1133: 61-70. PMID 24567094 DOI: 10.1007/978-1-4939-0357-3_3  0.696
2013 Simon GM, Niphakis MJ, Cravatt BF. Determining target engagement in living systems. Nature Chemical Biology. 9: 200-5. PMID 23508173 DOI: 10.1038/Nchembio.1211  0.516
2012 McNulty SN, Abubucker S, Simon GM, Mitreva M, McNulty NP, Fischer K, Curtis KC, Brattig NW, Weil GJ, Fischer PU. Transcriptomic and proteomic analyses of a Wolbachia-free filarial parasite provide evidence of trans-kingdom horizontal gene transfer. Plos One. 7: e45777. PMID 23049857 DOI: 10.1371/Journal.Pone.0045777  0.327
2012 Dix MM, Simon GM, Wang C, Okerberg E, Patricelli MP, Cravatt BF. Functional interplay between caspase cleavage and phosphorylation sculpts the apoptotic proteome. Cell. 150: 426-40. PMID 22817901 DOI: 10.1016/J.Cell.2012.05.040  0.75
2012 Simon GM, Cheng J, Gordon JI. Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice. Proceedings of the National Academy of Sciences of the United States of America. 109: 11133-8. PMID 22733758 DOI: 10.1073/Pnas.1208669109  0.425
2011 Bowyer PW, Simon GM, Cravatt BF, Bogyo M. Global profiling of proteolysis during rupture of Plasmodium falciparum from the host erythrocyte. Molecular & Cellular Proteomics : McP. 10: M110.001636. PMID 20943600 DOI: 10.1074/Mcp.M110.001636  0.512
2010 Weerapana E, Wang C, Simon GM, Richter F, Khare S, Dillon MB, Bachovchin DA, Mowen K, Baker D, Cravatt BF. Quantitative reactivity profiling predicts functional cysteines in proteomes. Nature. 468: 790-5. PMID 21085121 DOI: 10.1038/Nature09472  0.721
2010 Bachovchin DA, Ji T, Li W, Simon GM, Blankman JL, Adibekian A, Hoover H, Niessen S, Cravatt BF. Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening. Proceedings of the National Academy of Sciences of the United States of America. 107: 20941-6. PMID 21084632 DOI: 10.1073/Pnas.1011663107  0.528
2010 Gaultier A, Simon G, Niessen S, Dix M, Takimoto S, Cravatt BF, Gonias SL. LDL receptor-related protein 1 regulates the abundance of diverse cell-signaling proteins in the plasma membrane proteome. Journal of Proteome Research. 9: 6689-95. PMID 20919742 DOI: 10.1021/Pr1008288  0.68
2010 Kopp F, Komatsu T, Nomura DK, Trauger SA, Thomas JR, Siuzdak G, Simon GM, Cravatt BF. The glycerophospho metabolome and its influence on amino acid homeostasis revealed by brain metabolomics of GDE1(-/-) mice. Chemistry & Biology. 17: 831-40. PMID 20797612 DOI: 10.1016/J.Chembiol.2010.06.009  0.644
2010 Simon GM, Cravatt BF. Characterization of mice lacking candidate N-acyl ethanolamine biosynthetic enzymes provides evidence for multiple pathways that contribute to endocannabinoid production in vivo. Molecular Biosystems. 6: 1411-8. PMID 20393650 DOI: 10.1039/C000237B  0.516
2010 Simon GM, Cravatt BF. Activity-based proteomics of enzyme superfamilies: serine hydrolases as a case study. The Journal of Biological Chemistry. 285: 11051-5. PMID 20147750 DOI: 10.1074/Jbc.R109.097600  0.525
2010 Sipe JC, Scott TM, Murray S, Harismendy O, Simon GM, Cravatt BF, Waalen J. Biomarkers of endocannabinoid system activation in severe obesity. Plos One. 5: e8792. PMID 20098695 DOI: 10.1371/Journal.Pone.0008792  0.422
2009 Simon GM, Dix MM, Cravatt BF. Comparative assessment of large-scale proteomic studies of apoptotic proteolysis. Acs Chemical Biology. 4: 401-8. PMID 19415908 DOI: 10.1021/Cb900082Q  0.674
2008 Simon GM, Cravatt BF. Challenges for the 'chemical-systems' biologist. Nature Chemical Biology. 4: 639-42. PMID 18936742 DOI: 10.1038/Nchembio1108-639  0.437
2008 Dix MM, Simon GM, Cravatt BF. Global mapping of the topography and magnitude of proteolytic events in apoptosis. Cell. 134: 679-91. PMID 18724940 DOI: 10.1016/J.Cell.2008.06.038  0.71
2008 Weerapana E, Simon GM, Cravatt BF. Disparate proteome reactivity profiles of carbon electrophiles. Nature Chemical Biology. 4: 405-7. PMID 18488014 DOI: 10.1038/Nchembio.91  0.652
2008 Nomura DK, Blankman JL, Simon GM, Fujioka K, Issa RS, Ward AM, Cravatt BF, Casida JE. Activation of the endocannabinoid system by organophosphorus nerve agents. Nature Chemical Biology. 4: 373-8. PMID 18438404 DOI: 10.1038/Nchembio.86  0.636
2008 Simon GM, Cravatt BF. Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain. The Journal of Biological Chemistry. 283: 9341-9. PMID 18227059 DOI: 10.1074/Jbc.M707807200  0.488
2008 Egertová M, Simon GM, Cravatt BF, Elphick MR. Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective on N-acylethanolamines as neural signaling molecules. The Journal of Comparative Neurology. 506: 604-15. PMID 18067139 DOI: 10.1002/Cne.21568  0.48
2007 Blankman JL, Simon GM, Cravatt BF. A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chemistry & Biology. 14: 1347-56. PMID 18096503 DOI: 10.1016/J.Chembiol.2007.11.006  0.507
2007 Cravatt BF, Simon GM, Yates JR. The biological impact of mass-spectrometry-based proteomics. Nature. 450: 991-1000. PMID 18075578 DOI: 10.1038/Nature06525  0.507
2007 Hanson SR, Hsu TL, Weerapana E, Kishikawa K, Simon GM, Cravatt BF, Wong CH. Tailored glycoproteomics and glycan site mapping using saccharide-selective bioorthogonal probes. Journal of the American Chemical Society. 129: 7266-7. PMID 17506567 DOI: 10.1021/Ja0724083  0.68
2006 Simon GM, Cravatt BF. Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway. The Journal of Biological Chemistry. 281: 26465-72. PMID 16818490 DOI: 10.1074/Jbc.M604660200  0.515
2006 Leung D, Saghatelian A, Simon GM, Cravatt BF. Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids. Biochemistry. 45: 4720-6. PMID 16605240 DOI: 10.1021/Bi060163L  0.646
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