| Year |
Citation |
Score |
| 2023 |
Saha N, Baek DS, Mendoza RP, Robev D, Xu Y, Goldgur Y, De La Cruz MJ, de Stanchina E, Janes PW, Xu K, Dimitrov DS, Nikolov DB. Fully human monoclonal antibody targeting activated ADAM10 on colorectal cancer cells. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 161: 114494. PMID 36917886 DOI: 10.1016/j.biopha.2023.114494 |
0.38 |
|
| 2022 |
Saha N, Xu K, Zhu Z, Robev D, Kalidindi T, Xu Y, Himanen J, de Stanchina E, Pillarsetty NVK, Dimitrov DS, Nikolov DB. Inhibitory monoclonal antibody targeting ADAM17 expressed on cancer cells. Translational Oncology. 15: 101265. PMID 34768098 DOI: 10.1016/j.tranon.2021.101265 |
0.313 |
|
| 2021 |
Xu Y, Robev D, Saha N, Wang B, Dalva MB, Xu K, Himanen JP, Nikolov DB. The Ephb2 Receptor Uses Homotypic, Head-to-Tail Interactions within Its Ectodomain as an Autoinhibitory Control Mechanism. International Journal of Molecular Sciences. 22. PMID 34638814 DOI: 10.3390/ijms221910473 |
0.518 |
|
| 2021 |
Mason EO, Goldgur Y, Robev D, Freywald A, Nikolov DB, Himanen JP. Structure of the EphB6 receptor ectodomain. Plos One. 16: e0247335. PMID 33770085 DOI: 10.1371/journal.pone.0247335 |
0.407 |
|
| 2019 |
Laing ED, Navaratnarajah CK, Cheliout Da Silva S, Petzing SR, Xu Y, Sterling SL, Marsh GA, Wang LF, Amaya M, Nikolov DB, Cattaneo R, Broder CC, Xu K. Structural and functional analyses reveal promiscuous and species specific use of ephrin receptors by Cedar virus. Proceedings of the National Academy of Sciences of the United States of America. PMID 31548390 DOI: 10.1073/Pnas.1911773116 |
0.447 |
|
| 2018 |
Liu Y, Kaljunen H, Pavić A, Saarenpää T, Himanen JP, Nikolov DB, Goldman A. Binding of EphrinA5 to RET receptor tyrosine kinase: An in vitro study. Plos One. 13: e0198291. PMID 29889908 DOI: 10.1371/Journal.Pone.0198291 |
0.324 |
|
| 2017 |
Seegar TCM, Killingsworth LB, Saha N, Meyer PA, Patra D, Zimmerman B, Janes PW, Rubinstein E, Nikolov DB, Skiniotis G, Kruse AC, Blacklow SC. Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10. Cell. 171: 1638-1648.e7. PMID 29224781 DOI: 10.1016/J.Cell.2017.11.014 |
0.337 |
|
| 2016 |
Atapattu L, Saha N, Chheang C, Eissman MF, Xu K, Vail ME, Hii L, Llerena C, Liu Z, Horvay K, Abud HE, Kusebauch U, Moritz RL, Ding BS, Cao Z, ... ... Nikolov DB, et al. An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth. The Journal of Experimental Medicine. PMID 27503072 DOI: 10.1084/Jem.20151095 |
0.368 |
|
| 2015 |
Xu K, Chan YP, Bradel-Tretheway B, Akyol-Ataman Z, Zhu Y, Dutta S, Yan L, Feng Y, Wang LF, Skiniotis G, Lee B, Zhou ZH, Broder CC, Aguilar HC, Nikolov DB. Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly. Plos Pathogens. 11: e1005322. PMID 26646856 DOI: 10.1371/Journal.Ppat.1005322 |
0.339 |
|
| 2015 |
Lamminmaki U, Nikolov D, Himanen J. Eph Receptors as Drug Targets: Single-Chain Antibodies and Beyond. Current Drug Targets. 16: 1021-30. PMID 26028047 DOI: 10.2174/1389450116666150531154619 |
0.415 |
|
| 2015 |
Xu K, Olsen O, Tzvetkova-Robev D, Tessier-Lavigne M, Nikolov DB. The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation. Genes & Development. 29: 785-90. PMID 25838500 DOI: 10.1101/Gad.257675.114 |
0.46 |
|
| 2014 |
Nikolov DB, Xu K, Himanen JP. Homotypic receptor-receptor interactions regulating Eph signaling. Cell Adhesion & Migration. 8: 360-5. PMID 25530219 DOI: 10.4161/19336918.2014.971684 |
0.469 |
|
| 2014 |
Saha N, Kolev M, Nikolov DB. Structural features of the Nogo receptor signaling complexes at the neuron/myelin interface. Neuroscience Research. 87: 1-7. PMID 24956133 DOI: 10.1016/j.neures.2014.06.003 |
0.322 |
|
| 2014 |
Xu K, Wu Z, Renier N, Antipenko A, Tzvetkova-Robev D, Xu Y, Minchenko M, Nardi-Dei V, Rajashankar KR, Himanen J, Tessier-Lavigne M, Nikolov DB. Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism. Science (New York, N.Y.). 344: 1275-9. PMID 24876346 DOI: 10.1126/Science.1255149 |
0.784 |
|
| 2014 |
Barton WA, Dalton AC, Seegar TCM, Himanen JP, Nikolov DB. Tie2 and Eph receptor tyrosine kinase activation and signaling Cold Spring Harbor Perspectives in Biology. 6. PMID 24478383 DOI: 10.1101/Cshperspect.A009142 |
0.713 |
|
| 2013 |
Xu K, Rockx B, Xie Y, DeBuysscher BL, Fusco DL, Zhu Z, Chan YP, Xu Y, Luu T, Cer RZ, Feldmann H, Mokashi V, Dimitrov DS, Bishop-Lilly KA, Broder CC, ... Nikolov DB, et al. Crystal structure of the Hendra virus attachment G glycoprotein bound to a potent cross-reactive neutralizing human monoclonal antibody. Plos Pathogens. 9: e1003684. PMID 24130486 DOI: 10.1371/Journal.Ppat.1003684 |
0.35 |
|
| 2013 |
Paavilainen S, Grandy D, Karelehto E, Chang E, Susi P, Erdjument-Bromage H, Nikolov D, Himanen J. High-level expression of a full-length Eph receptor. Protein Expression and Purification. 92: 112-8. PMID 24036371 DOI: 10.1016/j.pep.2013.08.016 |
0.368 |
|
| 2013 |
Xu K, Tzvetkova-Robev D, Xu Y, Goldgur Y, Chan YP, Himanen JP, Nikolov DB. Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5. Proceedings of the National Academy of Sciences of the United States of America. 110: 14634-9. PMID 23959867 DOI: 10.1073/Pnas.1311000110 |
0.522 |
|
| 2013 |
Xu K, Xu Y, Rajashankar KR, Robev D, Nikolov DB. Crystal structures of Lgr4 and its complex with R-spondin1. Structure (London, England : 1993). 21: 1683-9. PMID 23891289 DOI: 10.1016/J.Str.2013.07.001 |
0.497 |
|
| 2013 |
Ferluga S, Hantgan R, Goldgur Y, Himanen JP, Nikolov DB, Debinski W. Biological and structural characterization of glycosylation on ephrin-A1, a preferred ligand for EphA2 receptor tyrosine kinase. The Journal of Biological Chemistry. 288: 18448-57. PMID 23661698 DOI: 10.1074/Jbc.M113.464008 |
0.304 |
|
| 2013 |
Nikolov DB, Xu K, Himanen JP. Eph/ephrin recognition and the role of Eph/ephrin clusters in signaling initiation. Biochimica Et Biophysica Acta. 1834: 2160-5. PMID 23628727 DOI: 10.1016/J.Bbapap.2013.04.020 |
0.458 |
|
| 2013 |
Yu X, Seegar TC, Dalton AC, Tzvetkova-Robev D, Goldgur Y, Rajashankar KR, Nikolov DB, Barton WA. Structural basis for angiopoietin-1-mediated signaling initiation. Proceedings of the National Academy of Sciences of the United States of America. 110: 7205-10. PMID 23592718 DOI: 10.1073/Pnas.1216890110 |
0.762 |
|
| 2013 |
Pekcec A, Yigitkanli K, Jung JE, Pallast S, Xing C, Antipenko A, Minchenko M, Nikolov DB, Holman TR, Lo EH, Van Leyen K. Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling Faseb Journal. 27: 437-445. PMID 23070608 DOI: 10.1096/fj.12-20689 |
0.702 |
|
| 2012 |
Xu K, Chan YP, Rajashankar KR, Khetawat D, Yan L, Kolev MV, Broder CC, Nikolov DB. New insights into the Hendra virus attachment and entry process from structures of the virus G glycoprotein and its complex with Ephrin-B2. Plos One. 7: e48742. PMID 23144952 DOI: 10.1371/Journal.Pone.0048742 |
0.391 |
|
| 2012 |
Atapattu L, Saha N, Llerena C, Vail ME, Scott AM, Nikolov DB, Lackmann M, Janes PW. Antibodies binding the ADAM10 substrate recognition domain inhibit Eph function. Journal of Cell Science. 125: 6084-93. PMID 23108669 DOI: 10.1242/Jcs.112631 |
0.363 |
|
| 2012 |
Chan YP, Lu M, Dutta S, Yan L, Barr J, Flora M, Feng YR, Xu K, Nikolov DB, Wang LF, Skiniotis G, Broder CC. Biochemical, conformational, and immunogenic analysis of soluble trimeric forms of henipavirus fusion glycoproteins. Journal of Virology. 86: 11457-71. PMID 22915804 DOI: 10.1128/Jvi.01318-12 |
0.344 |
|
| 2012 |
Steffen DL, Xu K, Nikolov DB, Broder CC. Henipavirus mediated membrane fusion, virus entry and targeted therapeutics. Viruses. 4: 280-308. PMID 22470837 DOI: 10.3390/V4020280 |
0.326 |
|
| 2012 |
Xu K, Broder CC, Nikolov DB. Ephrin-B2 and ephrin-B3 as functional henipavirus receptors. Seminars in Cell & Developmental Biology. 23: 116-23. PMID 22227101 DOI: 10.1016/J.Semcdb.2011.12.005 |
0.411 |
|
| 2012 |
Colgrave ML, Snelling HJ, Shiell BJ, Feng YR, Chan YP, Bossart KN, Xu K, Nikolov DB, Broder CC, Michalski WP. Site occupancy and glycan compositional analysis of two soluble recombinant forms of the attachment glycoprotein of Hendra virus. Glycobiology. 22: 572-84. PMID 22171062 DOI: 10.1093/Glycob/Cwr180 |
0.415 |
|
| 2011 |
Singla N, Erdjument-Bromage H, Himanen JP, Muir TW, Nikolov DB. A semisynthetic Eph receptor tyrosine kinase provides insight into ligand-induced kinase activation. Chemistry & Biology. 18: 361-71. PMID 21439481 DOI: 10.1016/J.Chembiol.2011.01.011 |
0.541 |
|
| 2011 |
Semavina M, Saha N, Kolev MV, Goldgur Y, Giger RJ, Himanen JP, Nikolov DB. Crystal structure of the Nogo-receptor-2. Protein Science : a Publication of the Protein Society. 20: 684-9. PMID 21308849 DOI: 10.1002/pro.597 |
0.36 |
|
| 2010 |
Singla N, Goldgur Y, Xu K, Paavilainen S, Nikolov DB, Himanen JP. Crystal structure of the ligand-binding domain of the promiscuous EphA4 receptor reveals two distinct conformations. Biochemical and Biophysical Research Communications. 399: 555-9. PMID 20678482 DOI: 10.1016/J.Bbrc.2010.07.109 |
0.635 |
|
| 2010 |
Himanen JP, Yermekbayeva L, Janes PW, Walker JR, Xu K, Atapattu L, Rajashankar KR, Mensinga A, Lackmann M, Nikolov DB, Dhe-Paganon S. Architecture of Eph receptor clusters. Proceedings of the National Academy of Sciences of the United States of America. 107: 10860-5. PMID 20505120 DOI: 10.1073/Pnas.1004148107 |
0.442 |
|
| 2010 |
Seegar TC, Eller B, Tzvetkova-Robev D, Kolev MV, Henderson SC, Nikolov DB, Barton WA. Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands. Molecular Cell. 37: 643-55. PMID 20227369 DOI: 10.1016/J.Molcel.2010.02.007 |
0.703 |
|
| 2009 |
Lesner A, Shilpi R, Ivanova A, Gawinowicz MA, Lesniak J, Nikolov D, Simm M. Identification of X-DING-CD4, a new member of human DING protein family that is secreted by HIV-1 resistant CD4(+) T cells and has anti-viral activity. Biochemical and Biophysical Research Communications. 389: 284-9. PMID 19720052 DOI: 10.1016/J.Bbrc.2009.08.140 |
0.733 |
|
| 2009 |
Himanen JP, Goldgur Y, Miao H, Myshkin E, Guo H, Buck M, Nguyen M, Rajashankar KR, Wang B, Nikolov DB. Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex. Embo Reports. 10: 722-8. PMID 19525919 DOI: 10.1038/embor.2009.91 |
0.395 |
|
| 2009 |
Goldgur Y, Paavilainen S, Nikolov D, Himanen JP. Structure of the ligand-binding domain of the EphB2 receptor at 2 A resolution. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 65: 71-4. PMID 19193989 DOI: 10.1107/S1744309108043078 |
0.447 |
|
| 2008 |
Xu K, Rajashankar KR, Chan YP, Himanen JP, Broder CC, Nikolov DB. Host cell recognition by the henipaviruses: crystal structures of the Nipah G attachment glycoprotein and its complex with ephrin-B3. Proceedings of the National Academy of Sciences of the United States of America. 105: 9953-8. PMID 18632560 DOI: 10.1073/Pnas.0804797105 |
0.436 |
|
| 2008 |
Singla N, Himanen JP, Muir TW, Nikolov DB. Toward the semisynthesis of multidomain transmembrane receptors: modification of Eph tyrosine kinases. Protein Science : a Publication of the Protein Society. 17: 1740-7. PMID 18628240 DOI: 10.1110/Ps.035659.108 |
0.565 |
|
| 2007 |
Himanen JP, Saha N, Nikolov DB. Cell-cell signaling via Eph receptors and ephrins. Current Opinion in Cell Biology. 19: 534-42. PMID 17928214 DOI: 10.1016/j.ceb.2007.08.004 |
0.319 |
|
| 2007 |
Nikolov D, Li C, Lackmann M, Jeffrey P, Himanen J. Crystal structure of the human ephrin-A5 ectodomain. Protein Science : a Publication of the Protein Society. 16: 996-1000. PMID 17400922 DOI: 10.1110/ps.062665807 |
0.367 |
|
| 2006 |
Barton WA, Tzvetkova-Robev D, Erdjument-Bromage H, Tempst P, Nikolov DB. Highly efficient selenomethionine labeling of recombinant proteins produced in mammalian cells. Protein Science : a Publication of the Protein Society. 15: 2008-13. PMID 16823037 DOI: 10.1110/Ps.062244206 |
0.646 |
|
| 2006 |
Barton WA, Tzvetkova-Robev D, Miranda EP, Kolev MV, Rajashankar KR, Himanen JP, Nikolov DB. Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex. Nature Structural & Molecular Biology. 13: 524-32. PMID 16732286 DOI: 10.1038/Nsmb1101 |
0.723 |
|
| 2005 |
Janes PW, Saha N, Barton WA, Kolev MV, Wimmer-Kleikamp SH, Nievergall E, Blobel CP, Himanen JP, Lackmann M, Nikolov DB. Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans. Cell. 123: 291-304. PMID 16239146 DOI: 10.1016/J.Cell.2005.08.014 |
0.685 |
|
| 2005 |
Nikolov DB, Li C, Barton WA, Himanen JP. Crystal structure of the ephrin-B1 ectodomain: implications for receptor recognition and signaling. Biochemistry. 44: 10947-53. PMID 16101278 DOI: 10.1021/Bi050789W |
0.705 |
|
| 2005 |
Day B, To C, Himanen JP, Smith FM, Nikolov DB, Boyd AW, Lackmann M. Three distinct molecular surfaces in ephrin-A5 are essential for a functional interaction with EphA3. The Journal of Biological Chemistry. 280: 26526-32. PMID 15901737 DOI: 10.1074/jbc.M504972200 |
0.33 |
|
| 2005 |
Barton WA, Tzvetkova D, Nikolov DB. Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition. Structure (London, England : 1993). 13: 825-32. PMID 15893672 DOI: 10.1016/J.Str.2005.03.009 |
0.723 |
|
| 2004 |
Barton WA, Himanen JP, Antipenko A, Nikolov DB. Structures of axon guidance molecules and their neuronal receptors. Advances in Protein Chemistry. 68: 65-106. PMID 15500859 DOI: 10.1016/S0065-3233(04)68003-X |
0.722 |
|
| 2004 |
Himanen JP, Chumley MJ, Lackmann M, Li C, Barton WA, Jeffrey PD, Vearing C, Geleick D, Feldheim DA, Boyd AW, Henkemeyer M, Nikolov DB. Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling. Nature Neuroscience. 7: 501-9. PMID 15107857 DOI: 10.1038/Nn1237 |
0.694 |
|
| 2004 |
Thorson JS, Barton WA, Hoffmeister D, Albermann C, Nikolov DB. Structure-based enzyme engineering and its impact on in vitro glycorandomization. Chembiochem : a European Journal of Chemical Biology. 5: 16-25. PMID 14695508 DOI: 10.1002/Cbic.200300620 |
0.64 |
|
| 2004 |
Smith FM, Vearing C, Lackmann M, Treutlein H, Himanen J, Chen K, Saul A, Nikolov D, Boyd AW. Dissecting the EphA3/Ephrin-A5 interactions using a novel functional mutagenesis screen. The Journal of Biological Chemistry. 279: 9522-31. PMID 14660665 DOI: 10.1074/jbc.M309326200 |
0.303 |
|
| 2003 |
Coyle JE, Nikolov DB. GABARAP: lessons for synaptogenesis. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 9: 205-16. PMID 15065816 DOI: 10.1177/1073858403009003013 |
0.347 |
|
| 2003 |
Lesniak J, Barton WA, Nikolov DB. Structural and functional features of the Escherichia coli hydroperoxide resistance protein OsmC. Protein Science : a Publication of the Protein Society. 12: 2838-43. PMID 14627744 DOI: 10.1110/Ps.03375603 |
0.754 |
|
| 2003 |
Antipenko A, Himanen JP, van Leyen K, Nardi-Dei V, Lesniak J, Barton WA, Rajashankar KR, Lu M, Hoemme C, Püschel AW, Nikolov DB. Structure of the semaphorin-3A receptor binding module. Neuron. 39: 589-98. PMID 12925274 DOI: 10.1016/S0896-6273(03)00502-6 |
0.78 |
|
| 2003 |
Barton WA, Liu BP, Tzvetkova D, Jeffrey PD, Fournier AE, Sah D, Cate R, Strittmatter SM, Nikolov DB. Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins. The Embo Journal. 22: 3291-302. PMID 12839991 DOI: 10.1093/Emboj/Cdg325 |
0.711 |
|
| 2003 |
Albermann C, Soriano A, Jiang J, Vollmer H, Biggins JB, Barton WA, Lesniak J, Nikolov DB, Thorson JS. Substrate specificity of NovM: implications for novobiocin biosynthesis and glycorandomization. Organic Letters. 5: 933-6. PMID 12633109 DOI: 10.1021/Ol0341086 |
0.726 |
|
| 2003 |
Himanen JP, Nikolov DB. Eph signaling: a structural view. Trends in Neurosciences. 26: 46-51. PMID 12495863 DOI: 10.1016/S0166-2236(02)00005-X |
0.343 |
|
| 2003 |
Himanen JP, Nikolov DB. Eph receptors and ephrins. The International Journal of Biochemistry & Cell Biology. 35: 130-4. PMID 12479863 DOI: 10.1016/S1357-2725(02)00096-1 |
0.366 |
|
| 2002 |
Lesniak J, Barton WA, Nikolov DB. Structural and functional characterization of the Pseudomonas hydroperoxide resistance protein Ohr. The Embo Journal. 21: 6649-59. PMID 12485986 DOI: 10.1093/Emboj/Cdf670 |
0.758 |
|
| 2002 |
Barton WA, Biggins JB, Jiang J, Thorson JS, Nikolov DB. Expanding pyrimidine diphosphosugar libraries via structure-based nucleotidylyltransferase engineering. Proceedings of the National Academy of Sciences of the United States of America. 99: 13397-402. PMID 12374866 DOI: 10.1073/Pnas.192468299 |
0.63 |
|
| 2002 |
Himanen JP, Nikolov DB. Purification, crystallization and preliminary characterization of an Eph-B2/ephrin-B2 complex. Acta Crystallographica. Section D, Biological Crystallography. 58: 533-5. PMID 11856847 DOI: 10.1107/S0907444902000264 |
0.32 |
|
| 2001 |
Himanen JP, Rajashankar KR, Lackmann M, Cowan CA, Henkemeyer M, Nikolov DB. Crystal structure of an Eph receptor-ephrin complex. Nature. 414: 933-8. PMID 11780069 DOI: 10.1038/414933A |
0.374 |
|
| 2001 |
Barton WA, Lesniak J, Biggins JB, Jeffrey PD, Jiang J, Rajashankar KR, Thorson JS, Nikolov DB. Structure, mechanism and engineering of a nucleotidylyltransferase as a first step toward glycorandomization. Nature Structural Biology. 8: 545-51. PMID 11373625 DOI: 10.1038/88618 |
0.746 |
|
| 1998 |
Himanen JP, Henkemeyer M, Nikolov DB. Crystal structure of the ligand-binding domain of the receptor tyrosine kinase EphB2. Nature. 396: 486-91. PMID 9853759 DOI: 10.1038/24904 |
0.375 |
|
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