Martha A. Alexander-Miller - Publications

Affiliations: 
Wake Forest University, Winston-Salem, NC, United States 
Area:
Immunology, Microbiology Biology

65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Stirling ER, Terabe M, Wilson AS, Kooshki M, Yamaleyeva LM, Alexander-Miller MA, Zhang W, Miller LD, Triozzi PL, Soto-Pantoja DR. Targeting the CD47/thrombospondin-1 signaling axis regulates immune cell bioenergetics in the tumor microenvironment to potentiate antitumor immune response. Journal For Immunotherapy of Cancer. 10. PMID 36418073 DOI: 10.1136/jitc-2022-004712  0.438
2020 Alexander-Miller MA. Challenges for the Newborn Following Influenza Virus Infection and Prospects for an Effective Vaccine. Frontiers in Immunology. 11: 568651. PMID 33042150 DOI: 10.3389/Fimmu.2020.568651  0.395
2020 Holbrook BC, Alexander-Miller MA. Higher Frequency and Increased Expression of Molecules Associated with Suppression on T Regulatory Cells from Newborn Compared with Adult Nonhuman Primates. Journal of Immunology (Baltimore, Md. : 1950). PMID 32878911 DOI: 10.4049/Jimmunol.2000461  0.51
2020 Crofts KF, Holbrook BC, Soto-Pantoja DR, Ornelles DA, Alexander-Miller MA. TCR Dependent Metabolic Programming Regulates Autocrine IL-4 Production Resulting in Self-Tuning of the CD8 T Cell Activation Setpoint. Frontiers in Immunology. 11: 540. PMID 32300344 DOI: 10.3389/Fimmu.2020.00540  0.518
2020 Clemens EA, Angeletti D, Holbrook BC, Kanekiyo M, Jorgensen MJ, Graham BS, Yewdell JW, Alexander-Miller MA. Influenza infected newborn and adult monkeys exhibit a strong primary antibody response to hemagglutinin stem. Jci Insight. PMID 32078584 DOI: 10.1172/Jci.Insight.135449  0.354
2019 Song Q, Hawkins GA, Wudel L, Chou PC, Forbes E, Pullikuth AK, Liu L, Jin G, Craddock L, Topaloglu U, Kucera G, O'Neill S, Levine EA, Sun P, Watabe K, ... ... Alexander-Miller MA, et al. Dissecting intratumoral myeloid cell plasticity by single cell RNA-seq. Cancer Medicine. PMID 31033233 DOI: 10.1002/Cam4.2113  0.302
2019 Song Q, Hawkins GA, Wudel L, Chou P, Forbes E, Pullikuth AK, Liu L, Jin G, Craddock L, Topaloglu U, Kucera G, O’Neill S, Levine EA, Sun P, Watabe K, ... ... Alexander-Miller MA, et al. Abstract 3391: Dissecting intratumoral cell-cell interactions in myeloid reprogramming by single cell RNA-seq Cancer Research. 79: 3391-3391. DOI: 10.1158/1538-7445.Am2019-3391  0.422
2018 Martin AN, Alexander-Miller M, Yoza BK, Vachharajani V, McCall CE. Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice. Journal of Immunology Research. 2018: 2402593. PMID 30069485 DOI: 10.1155/2018/2402593  0.501
2018 Westcott MM, Clemens EA, Holbrook BC, King SB, Alexander-Miller MA. The choice of linker for conjugating R848 to inactivated influenza virus determines the stimulatory capacity for innate immune cells. Vaccine. PMID 29398273 DOI: 10.1016/J.Vaccine.2018.01.035  0.313
2017 Blevins LK, Parsonage D, Oliver MB, Domzalski E, Swords WE, Alexander-Miller MA. A Novel Function for the Streptococcus pneumoniae Aminopeptidase N: Inhibition of T Cell Effector Function through Regulation of TCR Signaling. Frontiers in Immunology. 8: 1610. PMID 29230212 DOI: 10.3389/Fimmu.2017.01610  0.491
2017 Holbrook BC, Aycock ST, Machiele E, Clemens E, Gries D, Jorgensen MJ, Hadimani MB, King SB, Alexander-Miller MA. An R848 adjuvanted influenza vaccine promotes early activation of B cells in the draining lymph node of nonhuman primate neonates. Immunology. PMID 28940186 DOI: 10.1111/Imm.12845  0.349
2017 Wajih N, Basu S, Jailwala A, Kim HW, Ostrowski D, Perlegas A, Bolden CA, Buechler NL, Gladwin MT, Caudell DL, Rahbar E, Alexander-Miller MA, Vachharajani V, Kim-Shapiro DB. Potential therapeutic action of nitrite in sickle cell disease. Redox Biology. 12: 1026-1039. PMID 28511346 DOI: 10.1016/J.Redox.2017.05.006  0.333
2017 Grayson KM, Blevins LK, Oliver MB, Ornelles D, Swords WE, Alexander-Miller MA. Activation-dependent modulation of Streptococcus pneumoniae mediated death in human lymphocytes. Pathogens and Disease. PMID 28158464 DOI: 10.1093/Femspd/Ftx008  0.544
2017 Wren JT, Blevins LK, Pang B, Basu Roy A, Oliver MB, Reimche JL, Wozniak JE, Alexander-Miller MA, Swords WE. Pneumococcal neuraminidase A (NanA) promotes biofilm formation and synergizes with influenza A virus in nasal colonization and middle ear infection. Infection and Immunity. PMID 28096183 DOI: 10.1128/Iai.01044-16  0.362
2016 Holbrook BC, D'Agostino RB, Parks GD, Alexander-Miller MA. Adjuvanting an inactivated influenza vaccine with flagellin improves the function and quantity of the long-term antibody response in a nonhuman primate neonate model. Vaccine. PMID 27516064 DOI: 10.1016/J.Vaccine.2016.08.010  0.305
2016 Holbrook BC, Kim JR, Blevins LK, Jorgensen MJ, Kock ND, D'Agostino RB, Aycock ST, Hadimani MB, King SB, Parks GD, Alexander-Miller MA. A Novel R848-Conjugated Inactivated Influenza Virus Vaccine Is Efficacious and Safe in a Neonate Nonhuman Primate Model. Journal of Immunology (Baltimore, Md. : 1950). PMID 27279374 DOI: 10.4049/Jimmunol.1600497  0.319
2015 Holbrook BC, Hayward SL, Blevins LK, Kock N, Aycock T, Parks GD, Alexander-Miller MA. Nonhuman primate infants have an impaired respiratory but not systemic IgG antibody response following influenza virus infection. Virology. 476: 124-33. PMID 25543963 DOI: 10.1016/J.Virol.2014.12.007  0.35
2014 Alexander-Miller MA. Vaccines against respiratory viral pathogens for use in neonates: opportunities and challenges. Journal of Immunology (Baltimore, Md. : 1950). 193: 5363-9. PMID 25411431 DOI: 10.4049/Jimmunol.1401410  0.509
2014 Blevins LK, Wren JT, Holbrook BC, Hayward SL, Swords WE, Parks GD, Alexander-Miller MA. Coinfection with Streptococcus pneumoniae negatively modulates the size and composition of the ongoing influenza-specific CD8⁺ T cell response. Journal of Immunology (Baltimore, Md. : 1950). 193: 5076-87. PMID 25311807 DOI: 10.4049/Jimmunol.1400529  0.525
2014 Wren JT, Blevins LK, Pang B, King LB, Perez AC, Murrah KA, Reimche JL, Alexander-Miller MA, Swords WE. Influenza A virus alters pneumococcal nasal colonization and middle ear infection independently of phase variation. Infection and Immunity. 82: 4802-12. PMID 25156728 DOI: 10.1128/Iai.01856-14  0.346
2014 Shiner EK, Holbrook BC, Alexander-Miller MA. CD4+ T cell subset differentiation and avidity setpoint are dictated by the interplay of cytokine and antigen mediated signals. Plos One. 9: e100175. PMID 24940899 DOI: 10.1371/Journal.Pone.0100175  0.588
2013 Parks GD, Alexander-Miller MA. Paramyxovirus activation and inhibition of innate immune responses. Journal of Molecular Biology. 425: 4872-92. PMID 24056173 DOI: 10.1016/J.Jmb.2013.09.015  0.462
2013 Holbrook BC, Yammani RD, Blevins LK, Alexander-Miller MA. In vivo modulation of avidity in highly sensitive CD8(+) effector T cells following viral infection. Viral Immunology. 26: 302-13. PMID 23971914 DOI: 10.1089/Vim.2013.0042  0.579
2013 Amoah S, Holbrook BC, Yammani RD, Alexander-Miller MA. High viral burden restricts short-lived effector cell number at late times postinfection through increased natural regulatory T cell expansion. Journal of Immunology (Baltimore, Md. : 1950). 190: 5020-9. PMID 23589620 DOI: 10.4049/Jimmunol.1200971  0.776
2012 Beauchamp NM, Yammani RD, Alexander-Miller MA. CD8 marks a subpopulation of lung-derived dendritic cells with differential responsiveness to viral infection and toll-like receptor stimulation. Journal of Virology. 86: 10640-50. PMID 22811544 DOI: 10.1128/Jvi.01413-12  0.753
2012 Johnson JB, Lyles DS, Alexander-Miller MA, Parks GD. Virion-associated complement regulator CD55 is more potent than CD46 in mediating resistance of mumps virus and vesicular stomatitis virus to neutralization Journal of Virology. 86: 9929-9940. PMID 22761385 DOI: 10.1128/Jvi.01154-12  0.547
2012 Amoah S, Yammani RD, Grayson JM, Alexander-Miller MA. Changes in functional but not structural avidity during differentiation of CD8+ effector cells in vivo after virus infection. Journal of Immunology (Baltimore, Md. : 1950). 189: 638-45. PMID 22706075 DOI: 10.4049/Jimmunol.1102579  0.799
2011 Sharma SK, Alexander-Miller MA. Increased sensitivity to antigen in high avidity CD8(+) T cells results from augmented membrane proximal T-cell receptor signal transduction. Immunology. 133: 307-17. PMID 21501160 DOI: 10.1111/J.1365-2567.2011.03440.X  0.525
2011 Busick RY, Yammani RD, Alexander-Miller MA. Differentiation-dependent differences in murine T cell susceptibility to negative regulation by the lung. American Journal of Respiratory Cell and Molecular Biology. 44: 597-605. PMID 21216971 DOI: 10.1165/Rcmb.2010-0377Oc  0.557
2010 Beauchamp NM, Busick RY, Alexander-Miller MA. Functional divergence among CD103+ dendritic cell subpopulations following pulmonary poxvirus infection. Journal of Virology. 84: 10191-9. PMID 20660207 DOI: 10.1128/Jvi.00892-10  0.766
2010 Palmer EM, Holbrook BC, Arimilli S, Parks GD, Alexander-Miller MA. IFNgamma-producing, virus-specific CD8+ effector cells acquire the ability to produce IL-10 as a result of entry into the infected lung environment. Virology. 404: 225-30. PMID 20627346 DOI: 10.1016/J.Virol.2010.05.004  0.571
2010 Arimilli S, Sharma SK, Yammani R, Reid SD, Parks GD, Alexander-Miller MA. Pivotal Advance: Nonfunctional lung effectors exhibit decreased calcium mobilization associated with reduced expression of ORAI1. Journal of Leukocyte Biology. 87: 977-88. PMID 20103768 DOI: 10.1189/Jlb.0809575  0.501
2008 Arimilli S, Johnson JB, Clark KM, Graff AH, Alexander-Miller MA, Mizel SB, Parks GD. Engineered expression of the TLR5 ligand flagellin enhances paramyxovirus activation of human dendritic cell function. Journal of Virology. 82: 10975-85. PMID 18787007 DOI: 10.1128/Jvi.01288-08  0.582
2008 Yates NL, Yammani RD, Alexander-Miller MA. Dose-dependent lymphocyte apoptosis following respiratory infection with Vaccinia virus. Virus Research. 137: 198-205. PMID 18692098 DOI: 10.1016/J.Virusres.2008.07.010  0.543
2008 Yammani RD, Pejawar-Gaddy S, Gurley TC, Weimer ET, Hiltbold EM, Alexander-Miller MA. Regulation of maturation and activating potential in CD8+ versus CD8- dendritic cells following in vivo infection with vaccinia virus. Virology. 378: 142-50. PMID 18586296 DOI: 10.1016/J.Virol.2008.05.031  0.6
2008 Kroger CJ, Amoah S, Alexander-Miller MA. Cutting edge: Dendritic cells prime a high avidity CTL response independent of the level of presented antigen. Journal of Immunology (Baltimore, Md. : 1950). 180: 5784-8. PMID 18424695 DOI: 10.4049/Jimmunol.180.9.5784  0.762
2008 Arimilli S, Palmer EM, Alexander-Miller MA. Loss of function in virus-specific lung effector T cells is independent of infection. Journal of Leukocyte Biology. 83: 564-74. PMID 18079210 DOI: 10.1189/Jlb.0407215  0.46
2007 Kroger CJ, Alexander-Miller MA. Cutting edge: CD8+ T cell clones possess the potential to differentiate into both high- and low-avidity effector cells. Journal of Immunology (Baltimore, Md. : 1950). 179: 748-51. PMID 17617563 DOI: 10.4049/Jimmunol.179.2.748  0.796
2007 Kroger CJ, Alexander-Miller MA. Dose-dependent modulation of CD8 and functional avidity as a result of peptide encounter. Immunology. 122: 167-78. PMID 17484768 DOI: 10.1111/J.1365-2567.2007.02622.X  0.805
2007 Arimilli S, Johnson JB, Alexander-Miller MA, Parks GD. TLR-4 and -6 agonists reverse apoptosis and promote maturation of simian virus 5-infected human dendritic cells through NFkB-dependent pathways. Virology. 365: 144-56. PMID 17459446 DOI: 10.1016/J.Virol.2007.02.035  0.566
2007 Pejawar-Gaddy S, Gitiban-Vaghefi N, Parks GD, Alexander-Miller MA. Distinct pathways for signaling maturation in macrophages and dendritic cells after infection with paramyxovirus simian virus 5. Viral Immunology. 20: 76-87. PMID 17425423 DOI: 10.1089/Vim.2006.0070  0.667
2007 Yates NL, Alexander-Miller MA. Vaccinia virus infection of mature dendritic cells results in activation of virus-specific naïve CD8+ T cells: a potential mechanism for direct presentation. Virology. 359: 349-61. PMID 17056088 DOI: 10.1016/J.Virol.2006.09.020  0.665
2006 Dillon PJ, Wansley EK, Young VA, Alexander-Miller MA, Parks GD. Exchange of P/V genes between two non-cytopathic simian virus 5 variants results in a recombinant virus that kills cells through death pathways that are sensitive to caspase inhibitors. The Journal of General Virology. 87: 3643-8. PMID 17098980 DOI: 10.1099/Vir.0.82242-0  0.324
2006 Pejawar-Gaddy S, Alexander-Miller MA. Ligation of CD80 is critical for high-level CD25 expression on CD8+ T lymphocytes. Journal of Immunology (Baltimore, Md. : 1950). 177: 4495-502. PMID 16982886 DOI: 10.4049/Jimmunol.177.7.4495  0.557
2006 Hicks AM, Riedlinger G, Willingham MC, Alexander-Miller MA, Von Kap-Herr C, Pettenati MJ, Sanders AM, Weir HM, Du W, Kim J, Simpson AJ, Old LJ, Cui Z. Transferable anticancer innate immunity in spontaneous regression/complete resistance mice. Proceedings of the National Academy of Sciences of the United States of America. 103: 7753-8. PMID 16682640 DOI: 10.1073/Pnas.0602382103  0.362
2006 Arimilli S, Alexander-Miller MA, Parks GD. A simian virus 5 (SV5) P/V mutant is less cytopathic than wild-type SV5 in human dendritic cells and is a more effective activator of dendritic cell maturation and function. Journal of Virology. 80: 3416-27. PMID 16537609 DOI: 10.1128/Jvi.80.7.3416-3427.2006  0.537
2005 Pejawar SS, Parks GD, Alexander-Miller MA. Abortive versus productive viral infection of dendritic cells with a paramyxovirus results in differential upregulation of select costimulatory molecules. Journal of Virology. 79: 7544-57. PMID 15919909 DOI: 10.1128/Jvi.79.12.7544-7557.2005  0.642
2005 Gray PM, Arimilli S, Palmer EM, Parks GD, Alexander-Miller MA. Altered function in CD8+ T cells following paramyxovirus infection of the respiratory tract. Journal of Virology. 79: 3339-49. PMID 15731228 DOI: 10.1128/Jvi.79.6.3339-3349.2005  0.655
2005 Alexander-Miller MA. High-avidity CD8+ T cells: optimal soldiers in the war against viruses and tumors. Immunologic Research. 31: 13-24. PMID 15591619 DOI: 10.1385/Ir:31:1:13  0.602
2004 Gray PM, Parks GD, Alexander-Miller MA. Modulation of CD8+ T cell avidity by increasing the turnover of viral antigen during infection. Cellular Immunology. 231: 14-9. PMID 15919365 DOI: 10.1016/J.Cellimm.2004.12.002  0.648
2004 Cawthon AG, Kroger CJ, Alexander-Miller MA. High avidity CD8+ T cells generated from CD28-deficient or wildtype mice exhibit a differential dependence on lipid raft integrity for activation. Cellular Immunology. 227: 148-55. PMID 15135297 DOI: 10.1016/J.Cellimm.2004.03.001  0.804
2003 Snyder JT, Alexander-Miller MA, Berzofskyl JA, Belyakov IM. Molecular mechanisms and biological significance of CTL avidity. Current Hiv Research. 1: 287-94. PMID 15046253 DOI: 10.2174/1570162033485230  0.59
2003 Cui Z, Willingham MC, Hicks AM, Alexander-Miller MA, Howard TD, Hawkins GA, Miller MS, Weir HM, Du W, DeLong CJ. Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in mice. Proceedings of the National Academy of Sciences of the United States of America. 100: 6682-7. PMID 12724523 DOI: 10.1073/Pnas.1031601100  0.312
2003 Gray PM, Parks GD, Alexander-Miller MA. High avidity CD8+ T cells are the initial population elicited following viral infection of the respiratory tract. Journal of Immunology (Baltimore, Md. : 1950). 170: 174-81. PMID 12496398 DOI: 10.4049/Jimmunol.170.1.174  0.59
2002 Cawthon AG, Alexander-Miller MA. Optimal colocalization of TCR and CD8 as a novel mechanism for the control of functional avidity. Journal of Immunology (Baltimore, Md. : 1950). 169: 3492-8. PMID 12244138 DOI: 10.4049/Jimmunol.169.7.3492  0.55
2002 Spolski RJ, Alexander-Miller MA, Kuhn RE. Suppressed cytotoxic T lymphocyte responses in experimental cysticercosis Veterinary Parasitology. 106: 325-330. PMID 12079738 DOI: 10.1016/S0304-4017(02)00105-X  0.386
2002 Parks GD, Alexander-Miller MA. High avidity cytotoxic T lymphocytes to a foreign antigen are efficiently activated following immunization with a recombinant paramyxovirus, simian virus 5. The Journal of General Virology. 83: 1167-72. PMID 11961272 DOI: 10.1099/0022-1317-83-5-1167  0.401
2001 Derby MA, Snyder JT, Tse R, Alexander-Miller MA, Berzofsky JA. An abrupt and concordant initiation of apoptosis: Antigen-dependent death of CD8+ CTL European Journal of Immunology. 31: 2951-2959. PMID 11592071 DOI: 10.1002/1521-4141(2001010)31:10<2951::AID-IMMU2951>3.0.CO;2-Q  0.431
2001 Gray PM, Parks GD, Alexander-Miller MA. A novel CD8-independent high-avidity cytotoxic T-lymphocyte response directed against an epitope in the phosphoprotein of the paramyxovirus simian virus 5 Journal of Virology. 75: 10065-10072. PMID 11581375 DOI: 10.1128/Jvi.75.21.10065-10072.2001  0.553
2001 Cawthon AG, Lu H, Alexander-Miller MA. Peptide requirement for CTL activation reflects the sensitivity to CD3 engagement: Correlation with CD8αβ versus CD8αα expression Journal of Immunology. 167: 2577-2584. PMID 11509598 DOI: 10.4049/Jimmunol.167.5.2577  0.467
2001 Derby MA, Alexander-Miller MA, Tse R, Berzofsky JA. High-avidity CTL exploit two complementary mechanisms to provide better protection against viral infection than low-avidity CTL Journal of Immunology. 166: 1690-1697. PMID 11160212  0.41
2000 Alexander-Miller MA. Differential expansion and survival of high and low avidity cytotoxic T cell populations during the immune response to a viral infection Cellular Immunology. 201: 58-62. PMID 10805974 DOI: 10.1006/Cimm.1999.1632  0.498
1996 Alexander-Miller MA, Leggatt GR, Sarin A, Berzofsky JA. Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL Journal of Experimental Medicine. 184: 485-492. PMID 8760802 DOI: 10.1084/Jem.184.2.485  0.48
1996 Alexander-Miller MA, Leggatt GR, Berzofsky JA. Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy Proceedings of the National Academy of Sciences of the United States of America. 93: 4102-4107. PMID 8633023 DOI: 10.1073/pnas.93.9.4102  0.397
1993 Goss JA, Alexander-Miller MA, Gorka J, Flye MW, Connolly JM, Hansen TH. Specific prolongation of allograft survival by a T-cell-receptor-derived peptide Proceedings of the National Academy of Sciences of the United States of America. 90: 9872-9876. PMID 8234328 DOI: 10.1073/pnas.90.21.9872  0.31
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