| Year |
Citation |
Score |
| 2023 |
Cilento ME, Wen X, Reeve AB, Ukah OB, Snyder AA, Carrillo CM, Smith CP, Edwards K, Wahoski CC, Kitzler DR, Kodama EN, Mitsuya H, Parniak MA, Tedbury PR, Sarafianos SG. HIV-1 Resistance to Islatravir/Tenofovir Combination Therapy in Wild-Type or NRTI-Resistant Strains of Diverse HIV-1 Subtypes. Viruses. 15. PMID 37896768 DOI: 10.3390/v15101990 |
0.339 |
|
| 2019 |
Slack RL, Ilina TV, Xi Z, Giacobbi NS, Kawai G, Parniak MA, Sarafianos SG, Sluis Cremer N, Ishima R. Conformational Changes in HIV-1 Reverse Transcriptase that Facilitate Its Maturation. Structure (London, England : 1993). PMID 31471129 DOI: 10.1016/J.Str.2019.08.004 |
0.449 |
|
| 2019 |
Gong T, Patel SK, Parniak MA, Ballou B, Rohan LC. Nanocrystal Formulation Improves Vaginal Delivery of CSIC for HIV Prevention. Aaps Pharmscitech. 20: 286. PMID 31410664 DOI: 10.1208/S12249-019-1503-Z |
0.414 |
|
| 2019 |
Tang J, Do HT, Huber AD, Casey MC, Kirby KA, Wilson DJ, Kankanala J, Parniak MA, Sarafianos SG, Wang Z. Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker. European Journal of Medicinal Chemistry. 166: 390-399. PMID 30739822 DOI: 10.1016/J.Ejmech.2019.01.081 |
0.534 |
|
| 2018 |
Wang L, Tang J, Huber AD, Casey MC, Kirby KA, Wilson DJ, Kankanala J, Parniak MA, Sarafianos SG, Wang Z. 6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H. European Journal of Medicinal Chemistry. 156: 680-691. PMID 30031978 DOI: 10.1016/J.Ejmech.2018.07.035 |
0.542 |
|
| 2018 |
Wang L, Tang J, Huber AD, Casey MC, Kirby KA, Wilson DJ, Kankanala J, Xie J, Parniak MA, Sarafianos SG, Wang Z. 6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity. European Journal of Medicinal Chemistry. 156: 652-665. PMID 30031976 DOI: 10.1016/J.Ejmech.2018.07.039 |
0.524 |
|
| 2018 |
Ilina TV, Slack RL, Elder JH, Sarafianos SG, Parniak MA, Ishima R. Effect of tRNA on the Maturation of HIV-Reverse Transcriptase. Journal of Molecular Biology. PMID 29751015 DOI: 10.1016/J.Jmb.2018.02.027 |
0.482 |
|
| 2017 |
Gong T, Zhang W, Parniak MA, Graebing PW, Moncla B, Gupta P, Empey KM, Rohan LC. Preformulation and Vaginal Film Formulation Development of Microbicide Drug Candidate CSIC for HIV prevention. Journal of Pharmaceutical Innovation. 12: 142-154. PMID 28983328 DOI: 10.1007/S12247-017-9274-0 |
0.475 |
|
| 2017 |
Kirby KA, Myshakina NA, Christen MT, Chen YL, Schmidt HA, Huber AD, Xi Z, Kim S, Rao RK, Kramer ST, Yang Q, Singh K, Parniak MA, Wang Z, Ishima R, et al. A 2-hydroxyisoquinoline-1,3-dione active site RNase H inhibitor binds in multiple modes to HIV-1 reverse transcriptase. Antimicrobial Agents and Chemotherapy. PMID 28760905 DOI: 10.1128/Aac.01351-17 |
0.481 |
|
| 2017 |
Vernekar SKV, Tang J, Wu B, Huber AD, Casey MC, Myshakina NS, Wilson DJ, Kankanala J, Kirby KA, Parniak MA, Sarafianos SG, Wang Z. Double-winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity. Journal of Medicinal Chemistry. PMID 28525279 DOI: 10.1021/Acs.Jmedchem.7B00440 |
0.514 |
|
| 2017 |
Tang J, Vernekar SK, Chen YL, Miller L, Huber AD, Myshakina N, Sarafianos SG, Parniak MA, Wang Z. Synthesis, biological evaluation and molecular modeling of 2-Hydroxyisoquinoline-1,3-dione analogues as inhibitors of HIV reverse transcriptase associated ribonuclease H and polymerase. European Journal of Medicinal Chemistry. 133: 85-96. PMID 28384548 DOI: 10.1016/J.Ejmech.2017.03.059 |
0.502 |
|
| 2017 |
Huber AD, Michailidis E, Tang J, Puray-Chavez MN, Boftsi M, Wolf JJ, Boschert KN, Sheridan MA, Leslie MD, Kirby KA, Singh K, Mitsuya H, Parniak MA, Wang Z, Sarafianos SG. 3-hydroxypyrimidine-2,4-diones as novel hepatitis B virus antivirals targeting the viral ribonuclease H. Antimicrobial Agents and Chemotherapy. PMID 28320718 DOI: 10.1128/Aac.00245-17 |
0.322 |
|
| 2016 |
Salie ZL, Kirby KA, Michailidis E, Marchand B, Singh K, Rohan LC, Kodama EN, Mitsuya H, Parniak MA, Sarafianos SG. Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA). Proceedings of the National Academy of Sciences of the United States of America. PMID 27489345 DOI: 10.1073/Pnas.1605223113 |
0.457 |
|
| 2016 |
Shanmugasundaram U, Kovarova M, Ho PT, Schramm N, Wahl A, Parniak MA, Garcia JV. Efficient Inhibition of HIV Replication in the Gastrointestinal and Female Reproductive Tracts of Humanized BLT Mice by EFdA. Plos One. 11: e0159517. PMID 27438728 DOI: 10.1371/Journal.Pone.0159517 |
0.419 |
|
| 2016 |
Kankanala J, Kirby KA, Liu F, Miller LG, Nagy E, Wilson DJ, Parniak MA, Sarafianos SG, Wang Z. Design, Synthesis and Biological Evaluations of Hydroxypyridone Carboxylic Acids as Inhibitors of HIV Reverse Transcriptase-Associated RNase H. Journal of Medicinal Chemistry. PMID 27094954 DOI: 10.1021/Acs.Jmedchem.6B00465 |
0.539 |
|
| 2016 |
Tang J, Liu F, Nagy E, Miller LG, Kirby KA, Wilson DJ, Wu B, Sarafianos SG, Parniak MA, Wang Z. 2-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations. Journal of Medicinal Chemistry. PMID 26927866 DOI: 10.1021/Acs.Jmedchem.5B01879 |
0.527 |
|
| 2015 |
Yamada K, Wahba AS, Bernatchez JA, Ilina T, Martínez-Montero S, Habibian M, Deleavey GF, Götte M, Parniak MA, Damha MJ. Nucleotide Sugar Pucker Preference Mitigates Excision by HIV-1 RT. Acs Chemical Biology. 10: 2024-33. PMID 26131619 DOI: 10.1021/Acschembio.5B00263 |
0.483 |
|
| 2015 |
Slack RL, Spiriti J, Ahn J, Parniak MA, Zuckerman DM, Ishima R. Structural integrity of the ribonuclease H domain in HIV-1 reverse transcriptase. Proteins. 83: 1526-38. PMID 26061827 DOI: 10.1002/Prot.24843 |
0.424 |
|
| 2015 |
Stoddart CA, Galkina SA, Joshi P, Kosikova G, Moreno ME, Rivera JM, Sloan B, Reeve AB, Sarafianos SG, Murphey-Corb M, Parniak MA. Oral Administration of the Nucleoside EFdA (4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine) Provides Rapid Suppression of HIV Viremia in Humanized Mice and Favorable Pharmacokinetic Properties in Mice and the Rhesus Macaque. Antimicrobial Agents and Chemotherapy. 59: 4190-8. PMID 25941222 DOI: 10.1128/Aac.05036-14 |
0.485 |
|
| 2015 |
Zhang W, Hu M, Shi Y, Gong T, Dezzutti CS, Moncla B, Sarafianos SG, Parniak MA, Rohan LC. Vaginal Microbicide Film Combinations of Two Reverse Transcriptase Inhibitors, EFdA and CSIC, for the Prevention of HIV-1 Sexual Transmission. Pharmaceutical Research. PMID 25794967 DOI: 10.1007/S11095-015-1678-2 |
0.492 |
|
| 2015 |
Martínez-Montero S, Deleavey GF, Dierker-Viik A, Lindovska P, Ilina T, Portella G, Orozco M, Parniak MA, González C, Damha MJ. Synthesis and properties of 2'-deoxy-2',4'-difluoroarabinose-modified nucleic acids. The Journal of Organic Chemistry. 80: 3083-91. PMID 25723361 DOI: 10.1021/Jo502948T |
0.334 |
|
| 2015 |
Vernekar SK, Liu Z, Nagy E, Miller L, Kirby KA, Wilson DJ, Kankanala J, Sarafianos SG, Parniak MA, Wang Z. Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1,3-diones: dual inhibition against HIV reverse transcriptase-associated RNase H and polymerase with antiviral activities. Journal of Medicinal Chemistry. 58: 651-64. PMID 25522204 DOI: 10.1021/Jm501132S |
0.467 |
|
| 2015 |
Yamada K, Wahba AS, Bernatchez JA, Ilina T, Martínez-Montero S, Habibian M, Deleavey GF, Götte M, Parniak MA, Damha MJ. Nucleotide Sugar Pucker Preference Mitigates Excision by HIV-1 RT Acs Chemical Biology. 10: 2024-2033. DOI: 10.1021/acschembio.5b00263 |
0.389 |
|
| 2015 |
Slack RL, Spiriti J, Ahn J, Parniak MA, Zuckerman DM, Ishima R. Structural integrity of the ribonuclease H domain in HIV-1 reverse transcriptase Proteins: Structure, Function and Bioinformatics. DOI: 10.1002/prot.24843 |
0.363 |
|
| 2014 |
Singh K, Flores JA, Kirby KA, Neogi U, Sonnerborg A, Hachiya A, Das K, Arnold E, McArthur C, Parniak M, Sarafianos SG. Drug resistance in non-B subtype HIV-1: impact of HIV-1 reverse transcriptase inhibitors. Viruses. 6: 3535-62. PMID 25254383 DOI: 10.3390/V6093535 |
0.477 |
|
| 2014 |
Michailidis E, Huber AD, Ryan EM, Ong YT, Leslie MD, Matzek KB, Singh K, Marchand B, Hagedorn AN, Kirby KA, Rohan LC, Kodama EN, Mitsuya H, Parniak MA, Sarafianos SG. 4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) inhibits HIV-1 reverse transcriptase with multiple mechanisms. The Journal of Biological Chemistry. 289: 24533-48. PMID 24970894 DOI: 10.1074/Jbc.M114.562694 |
0.532 |
|
| 2014 |
Himmel DM, Myshakina NS, Ilina T, Van Ry A, Ho WC, Parniak MA, Arnold E. Structure of a dihydroxycoumarin active-site inhibitor in complex with the RNase H domain of HIV-1 reverse transcriptase and structure-activity analysis of inhibitor analogs. Journal of Molecular Biology. 426: 2617-31. PMID 24840303 DOI: 10.1016/J.Jmb.2014.05.006 |
0.54 |
|
| 2014 |
Sharaf NG, Poliner E, Slack RL, Christen MT, Byeon IJ, Parniak MA, Gronenborn AM, Ishima R. The p66 immature precursor of HIV-1 reverse transcriptase. Proteins. 82: 2343-52. PMID 24771554 DOI: 10.1002/Prot.24594 |
0.415 |
|
| 2014 |
Zhang W, Parniak MA, Sarafianos SG, Empey PE, Rohan LC. In vitro transport characteristics of EFdA, a novel nucleoside reverse transcriptase inhibitor using Caco-2 and MDCKII cell monolayers. European Journal of Pharmacology. 732: 86-95. PMID 24690257 DOI: 10.1016/J.Ejphar.2014.03.022 |
0.416 |
|
| 2014 |
Zhang W, Parniak MA, Sarafianos SG, Cost MR, Rohan LC. Development of a vaginal delivery film containing EFdA, a novel anti-HIV nucleoside reverse transcriptase inhibitor. International Journal of Pharmaceutics. 461: 203-13. PMID 24333452 DOI: 10.1016/J.Ijpharm.2013.11.056 |
0.313 |
|
| 2014 |
Zhang W, Parniak MA, Mitsuya H, Sarafianos SG, Graebing PW, Rohan LC. Preformulation studies of EFdA, a novel nucleoside reverse transcriptase inhibitor for HIV prevention. Drug Development and Industrial Pharmacy. 40: 1101-11. PMID 23841536 DOI: 10.3109/03639045.2013.809535 |
0.389 |
|
| 2013 |
Sirivolu VR, Vernekar SK, Ilina T, Myshakina NS, Parniak MA, Wang Z. Clicking 3'-azidothymidine into novel potent inhibitors of human immunodeficiency virus. Journal of Medicinal Chemistry. 56: 8765-80. PMID 24102161 DOI: 10.1021/Jm401232V |
0.559 |
|
| 2013 |
Kirby KA, Michailidis E, Fetterly TL, Steinbach MA, Singh K, Marchand B, Leslie MD, Hagedorn AN, Kodama EN, Marquez VE, Hughes SH, Mitsuya H, Parniak MA, Sarafianos SG. Effects of substitutions at the 4' and 2 positions on the bioactivity of 4'-ethynyl-2-fluoro-2'-deoxyadenosine. Antimicrobial Agents and Chemotherapy. 57: 6254-64. PMID 24100493 DOI: 10.1128/Aac.01703-13 |
0.448 |
|
| 2013 |
Michailidis E, Ryan EM, Hachiya A, Kirby KA, Marchand B, Leslie MD, Huber AD, Ong YT, Jackson JC, Singh K, Kodama EN, Mitsuya H, Parniak MA, Sarafianos SG. Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA. Retrovirology. 10: 65. PMID 23800377 DOI: 10.1186/1742-4690-10-65 |
0.513 |
|
| 2013 |
Obitte NC, Rohan LC, Adeyeye CM, Parniak MA, Esimone CO. The utility of self-emulsifying oil formulation to improve the poor solubility of the anti HIV drug CSIC. Aids Research and Therapy. 10: 14. PMID 23721408 DOI: 10.1186/1742-6405-10-14 |
0.434 |
|
| 2013 |
Tavis JE, Cheng X, Hu Y, Totten M, Cao F, Michailidis E, Aurora R, Meyers MJ, Jacobsen EJ, Parniak MA, Sarafianos SG. The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes. Plos Pathogens. 9: e1003125. PMID 23349632 DOI: 10.1371/Journal.Ppat.1003125 |
0.424 |
|
| 2013 |
Eade CR, Cole AL, Diaz C, Rohan LC, Parniak MA, Marx P, Tarwater PM, Gupta P, Cole AM. The anti-HIV microbicide candidate RC-101 inhibits pathogenic vaginal bacteria without harming endogenous flora or mucosa. American Journal of Reproductive Immunology (New York, N.Y. : 1989). 69: 150-8. PMID 23167830 DOI: 10.1111/Aji.12036 |
0.432 |
|
| 2012 |
Yang H, Parniak MA, Hillier SL, Rohan LC. A thermodynamic study of the cyclodextrin-UC781 inclusion complex using a HPLC method. Journal of Inclusion Phenomena and Macrocyclic Chemistry. 72: 459-465. PMID 26097403 DOI: 10.1007/S10847-011-0019-2 |
0.352 |
|
| 2012 |
Ilina T, Labarge K, Sarafianos SG, Ishima R, Parniak MA. Inhibitors of HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity. Biology. 1: 521-41. PMID 23599900 DOI: 10.3390/Biology1030521 |
0.548 |
|
| 2012 |
Michailidis E, Singh K, Ryan EM, Hachiya A, Ong YT, Kirby KA, Marchand B, Kodama EN, Mitsuya H, Parniak MA, Sarafianos SG. Effect of translocation defective reverse transcriptase inhibitors on the activity of N348I, a connection subdomain drug resistant HIV-1 reverse transcriptase mutant. Cellular and Molecular Biology (Noisy-Le-Grand, France). 58: 187-95. PMID 23273211 DOI: 10.1170/T940 |
0.526 |
|
| 2012 |
Singh K, Marchand B, Rai DK, Sharma B, Michailidis E, Ryan EM, Matzek KB, Leslie MD, Hagedorn AN, Li Z, Norden PR, Hachiya A, Parniak MA, Xu HT, Wainberg MA, et al. Biochemical mechanism of HIV-1 resistance to rilpivirine. The Journal of Biological Chemistry. 287: 38110-23. PMID 22955279 DOI: 10.1074/Jbc.M112.398180 |
0.387 |
|
| 2012 |
Christen MT, Menon L, Myshakina NS, Ahn J, Parniak MA, Ishima R. Structural basis of the allosteric inhibitor interaction on the HIV-1 reverse transcriptase RNase H domain. Chemical Biology & Drug Design. 80: 706-16. PMID 22846652 DOI: 10.1111/Cbdd.12010 |
0.469 |
|
| 2012 |
Murphey-Corb M, Rajakumar P, Michael H, Nyaundi J, Didier PJ, Reeve AB, Mitsuya H, Sarafianos SG, Parniak MA. Response of simian immunodeficiency virus to the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine in vitro and in vivo. Antimicrobial Agents and Chemotherapy. 56: 4707-12. PMID 22713337 DOI: 10.1128/Aac.00723-12 |
0.426 |
|
| 2012 |
Bunge K, Macio I, Meyn L, Noguchi L, Parniak MA, Schwartz JL, Moncla B, Hillier S. The safety, persistence, and acceptability of an antiretroviral microbicide candidate UC781. Journal of Acquired Immune Deficiency Syndromes (1999). 60: 337-43. PMID 22495787 DOI: 10.1097/Qai.0B013E3182575914 |
0.372 |
|
| 2012 |
Kirby KA, Marchand B, Ong YT, Ndongwe TP, Hachiya A, Michailidis E, Leslie MD, Sietsema DV, Fetterly TL, Dorst CA, Singh K, Wang Z, Parniak MA, Sarafianos SG. Structural and inhibition studies of the RNase H function of xenotropic murine leukemia virus-related virus reverse transcriptase. Antimicrobial Agents and Chemotherapy. 56: 2048-61. PMID 22252812 DOI: 10.1128/Aac.06000-11 |
0.537 |
|
| 2012 |
Li M, Shandilya SM, Carpenter MA, Rathore A, Brown WL, Perkins AL, Harki DA, Solberg J, Hook DJ, Pandey KK, Parniak MA, Johnson JR, Krogan NJ, Somasundaran M, Ali A, et al. First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G. Acs Chemical Biology. 7: 506-17. PMID 22181350 DOI: 10.1021/Cb200440Y |
0.446 |
|
| 2012 |
Ndongwe TP, Adedeji AO, Michailidis E, Ong YT, Hachiya A, Marchand B, Ryan EM, Rai DK, Kirby KA, Whatley AS, Burke DH, Johnson M, Ding S, Zheng YM, Liu SL, ... ... Parniak MA, et al. Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase. Nucleic Acids Research. 40: 345-59. PMID 21908397 DOI: 10.1093/Nar/Gkr694 |
0.555 |
|
| 2011 |
Akil A, Parniak MA, Dezzuitti CS, Moncla BJ, Cost MR, Li M, Rohan LC. Development and Characterization of a Vaginal Film Containing Dapivirine, a Non- nucleoside Reverse Transcriptase Inhibitor (NNRTI), for prevention of HIV-1 sexual transmission. Drug Delivery and Translational Research. 1: 209-222. PMID 22708075 DOI: 10.1007/S13346-011-0022-6 |
0.378 |
|
| 2011 |
Davis CA, Parniak MA, Hughes SH. The effects of RNase H inhibitors and nevirapine on the susceptibility of HIV-1 to AZT and 3TC. Virology. 419: 64-71. PMID 21907380 DOI: 10.1016/J.Virol.2011.08.010 |
0.52 |
|
| 2011 |
Felts AK, Labarge K, Bauman JD, Patel DV, Himmel DM, Arnold E, Parniak MA, Levy RM. Identification of alternative binding sites for inhibitors of HIV-1 ribonuclease H through comparative analysis of virtual enrichment studies. Journal of Chemical Information and Modeling. 51: 1986-98. PMID 21714567 DOI: 10.1021/Ci200194W |
0.421 |
|
| 2011 |
Kirby KA, Singh K, Michailidis E, Marchand B, Kodama EN, Ashida N, Mitsuya H, Parniak MA, Sarafianos SG. The sugar ring conformation of 4'-ethynyl-2-fluoro-2'-deoxyadenosine and its recognition by the polymerase active site of HIV reverse transcriptase. Cellular and Molecular Biology (Noisy-Le-Grand, France). 57: 40-6. PMID 21366961 DOI: 10.1170/T900 |
0.418 |
|
| 2011 |
Gong Q, Menon L, Ilina T, Miller LG, Ahn J, Parniak MA, Ishima R. Interaction of HIV-1 reverse transcriptase ribonuclease H with an acylhydrazone inhibitor. Chemical Biology & Drug Design. 77: 39-47. PMID 21114787 DOI: 10.1111/J.1747-0285.2010.01052.X |
0.497 |
|
| 2011 |
Menon L, Gong Q, Ahn J, Parniak MA, Ishima R. Structural Studies of RNase H Domain to Develop HIV-1 Reverse Transcriptase Inhibitors using Solution NMR Biophysical Journal. 100: 605a. DOI: 10.1016/J.Bpj.2010.12.3482 |
0.489 |
|
| 2010 |
Abram ME, Sarafianos SG, Parniak MA. The mutation T477A in HIV-1 reverse transcriptase (RT) restores normal proteolytic processing of RT in virus with Gag-Pol mutated in the p51-RNH cleavage site. Retrovirology. 7: 6. PMID 20122159 DOI: 10.1186/1742-4690-7-6 |
0.718 |
|
| 2009 |
Han Q, Sarafianos SG, Arnold E, Parniak MA, Gaffney BL, Jones RA. Synthesis of Boranoate, Selenoate, and Thioate Analogs of AZTp(4)A and Ap(4)A. Tetrahedron. 65: 7915-7920. PMID 20625456 DOI: 10.1016/J.Tet.2009.07.079 |
0.392 |
|
| 2009 |
Michailidis E, Marchand B, Kodama EN, Singh K, Matsuoka M, Kirby KA, Ryan EM, Sawani AM, Nagy E, Ashida N, Mitsuya H, Parniak MA, Sarafianos SG. Mechanism of inhibition of HIV-1 reverse transcriptase by 4'-Ethynyl-2-fluoro-2'-deoxyadenosine triphosphate, a translocation-defective reverse transcriptase inhibitor. The Journal of Biological Chemistry. 284: 35681-91. PMID 19837673 DOI: 10.1074/Jbc.M109.036616 |
0.535 |
|
| 2009 |
Sarafianos SG, Marchand B, Das K, Himmel DM, Parniak MA, Hughes SH, Arnold E. Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition. Journal of Molecular Biology. 385: 693-713. PMID 19022262 DOI: 10.1016/J.Jmb.2008.10.071 |
0.466 |
|
| 2008 |
Yang H, Parniak MA, Isaacs CE, Hillier SL, Rohan LC. Characterization of cyclodextrin inclusion complexes of the anti-HIV non-nucleoside reverse transcriptase inhibitor UC781. The Aaps Journal. 10: 606-13. PMID 19089644 DOI: 10.1208/S12248-008-9070-3 |
0.319 |
|
| 2008 |
Song Y, Chan JM, Tovian Z, Secrest A, Nagy E, Krysiak K, Bergan K, Parniak MA, Oldfield E. Bisphosphonate inhibitors of ATP-mediated HIV-1 reverse transcriptase catalyzed excision of chain-terminating 3'-azido, 3'-deoxythymidine: a QSAR investigation. Bioorganic & Medicinal Chemistry. 16: 8959-67. PMID 18789701 DOI: 10.1016/J.Bmc.2008.08.047 |
0.525 |
|
| 2008 |
Garforth SJ, Parniak MA, Prasad VR. Utilization of a deoxynucleoside diphosphate substrate by HIV reverse transcriptase. Plos One. 3: e2074. PMID 18446195 DOI: 10.1371/Journal.Pone.0002074 |
0.538 |
|
| 2008 |
Ilina T, Parniak MA. Inhibitors of HIV-1 reverse transcriptase. Advances in Pharmacology (San Diego, Calif.). 56: 121-67. PMID 18086411 DOI: 10.1016/S1054-3589(07)56005-9 |
0.414 |
|
| 2008 |
Michailidis L, Marchand B, Kodama E, Fopoussi AOM, Sawani A, Ryan E, Eisele N, Matsuoka M, Ashida N, Nagy E, Parniak M, Mitsuya H, Sarafianos S. Novel Inhibition Mechanism and Potent Activity of Translocation-deficient Reverse Transcriptase Inhibitors International Journal of Infectious Diseases. 12: S24-S25. DOI: 10.1016/S1201-9712(08)60058-2 |
0.337 |
|
| 2007 |
Han Q, Sarafianos SG, Arnold E, Parniak MA, Gaffney BL, Jones RA. Synthesis of AZTpSpCX2ppSA and AZTpSpCX2ppSAZT: hydrolysis-resistant potential inhibitors of the AZT excision reaction of HIV-1 RT. Organic Letters. 9: 5243-6. PMID 17988141 DOI: 10.1021/Ol7023746 |
0.429 |
|
| 2007 |
Patton DL, Cosgrove Sweeney YT, Balkus JE, Rohan LC, Moncla BJ, Parniak MA, Hillier SL. Preclinical safety assessments of UC781 anti-human immunodeficiency virus topical microbicide formulations Antimicrobial Agents and Chemotherapy. 51: 1608-1615. PMID 17353240 DOI: 10.1128/Aac.00984-06 |
0.404 |
|
| 2007 |
Dharmasena S, Pongracz Z, Arnold E, Sarafianos SG, Parniak MA. 3'-Azido-3'-deoxythymidine-(5')-tetraphospho-(5')-adenosine, the product of ATP-mediated excision of chain-terminating AZTMP, is a potent chain-terminating substrate for HIV-1 reverse transcriptase. Biochemistry. 46: 828-36. PMID 17223704 DOI: 10.1021/Bi061364S |
0.513 |
|
| 2007 |
Garforth SJ, Kim TW, Parniak MA, Kool ET, Prasad VR. Site-directed mutagenesis in the fingers subdomain of HIV-1 reverse transcriptase reveals a specific role for the beta3-beta4 hairpin loop in dNTP selection. Journal of Molecular Biology. 365: 38-49. PMID 17055529 DOI: 10.1016/J.Jmb.2006.09.057 |
0.457 |
|
| 2006 |
Himmel DM, Sarafianos SG, Dharmasena S, Hossain MM, McCoy-Simandle K, Ilina T, Clark AD, Knight JL, Julias JG, Clark PK, Krogh-Jespersen K, Levy RM, Hughes SH, Parniak MA, Arnold E. HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site. Acs Chemical Biology. 1: 702-12. PMID 17184135 DOI: 10.1021/Cb600303Y |
0.556 |
|
| 2006 |
Gupta P, Ratner D, Patterson BK, Kulka K, Rohan LC, Parniak MA, Isaacs CE, Hillier S. Use of frozen-thawed cervical tissues in the organ culture system to measure anti-HIV activities of candidate microbicides. Aids Research and Human Retroviruses. 22: 419-24. PMID 16706618 DOI: 10.1089/Aid.2006.22.419 |
0.381 |
|
| 2006 |
Hossain MM, Parniak MA. In vitro microbicidal activity of the nonnucleoside reverse transcriptase inhibitor (NNRTI) UC781 against NNRTI-resistant human immunodeficiency virus type 1. Journal of Virology. 80: 4440-6. PMID 16611904 DOI: 10.1128/Jvi.80.9.4440-4446.2006 |
0.482 |
|
| 2005 |
Abram ME, Parniak MA. Virion instability of human immunodeficiency virus type 1 reverse transcriptase (RT) mutated in the protease cleavage site between RT p51 and the RT RNase H domain. Journal of Virology. 79: 11952-61. PMID 16140771 DOI: 10.1128/Jvi.79.18.11952-11961.2005 |
0.75 |
|
| 2005 |
Sluis-Cremer N, Arion D, Parikh U, Koontz D, Schinazi RF, Mellors JW, Parniak MA. The 3'-azido group is not the primary determinant of 3'-azido-3'-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1. The Journal of Biological Chemistry. 280: 29047-52. PMID 15970587 DOI: 10.1074/Jbc.M503166200 |
0.456 |
|
| 2005 |
Budihas SR, Gorshkova I, Gaidamakov S, Wamiru A, Bona MK, Parniak MA, Crouch RJ, McMahon JB, Beutler JA, Le Grice SF. Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones. Nucleic Acids Research. 33: 1249-56. PMID 15741178 DOI: 10.1093/Nar/Gki268 |
0.528 |
|
| 2005 |
Shaw-Reid CA, Feuston B, Munshi V, Getty K, Krueger J, Hazuda DJ, Parniak MA, Miller MD, Lewis D. Dissecting the effects of DNA polymerase and ribonuclease H inhibitor combinations on HIV-1 reverse-transcriptase activities. Biochemistry. 44: 1595-606. PMID 15683243 DOI: 10.1021/Bi0486740 |
0.472 |
|
| 2005 |
Himmel DM, Sarafianos SG, Dharmasena S, Hossain M, McCoy-Simandle K, Clark PK, Clark Jr AD, Knight JL, Levy RM, Hughes SH, Parniak MA, Arnold E. X-ray structure for an RNase H inhibitor bound to HIV-1 reverse transcriptase Acta Crystallographica Section a Foundations of Crystallography. 61: c249-c249. DOI: 10.1107/S0108767305089397 |
0.45 |
|
| 2004 |
Chan KC, Budihas SR, Le Grice SF, Parniak MA, Crouch RJ, Gaidamakov SA, Isaaq HJ, Wamiru A, McMahon JB, Beutler JA. A capillary electrophoretic assay for ribonuclease H activity. Analytical Biochemistry. 331: 296-302. PMID 15265735 DOI: 10.1016/J.Ab.2004.05.017 |
0.477 |
|
| 2004 |
Sluis-Cremer N, Arion D, Abram ME, Parniak MA. Proteolytic processing of an HIV-1 pol polyprotein precursor: insights into the mechanism of reverse transcriptase p66/p51 heterodimer formation. The International Journal of Biochemistry & Cell Biology. 36: 1836-47. PMID 15183348 DOI: 10.1016/J.Biocel.2004.02.020 |
0.733 |
|
| 2004 |
Parniak MA. HIV/AIDS after twenty-five years. The International Journal of Biochemistry & Cell Biology. 36: 1666-7. PMID 15183336 DOI: 10.1016/J.Biocel.2004.04.001 |
0.46 |
|
| 2003 |
Parniak MA, Min KL, Budihas SR, Le Grice SF, Beutler JA. A fluorescence-based high-throughput screening assay for inhibitors of human immunodeficiency virus-1 reverse transcriptase-associated ribonuclease H activity. Analytical Biochemistry. 322: 33-9. PMID 14705777 DOI: 10.1016/J.Ab.2003.06.001 |
0.407 |
|
| 2003 |
Sluis-Cremer N, Kempner E, Parniak MA. Structure-activity relationships in HIV-1 reverse transcriptase revealed by radiation target analysis. Protein Science : a Publication of the Protein Society. 12: 2081-6. PMID 12931006 DOI: 10.1110/Ps.03130503 |
0.484 |
|
| 2003 |
Mangos MM, Min KL, Viazovkina E, Galarneau A, Elzagheid MI, Parniak MA, Damha MJ. Efficient RNase H-directed cleavage of RNA promoted by antisense DNA or 2'F-ANA constructs containing acyclic nucleotide inserts. Journal of the American Chemical Society. 125: 654-61. PMID 12526664 DOI: 10.1021/Ja025557O |
0.35 |
|
| 2002 |
Loemba H, Brenner B, Parniak MA, Ma'ayan S, Spira B, Moisi D, Oliveira M, Detorio M, Essex M, Wainberg MA. Polymorphisms of cytotoxic T-lymphocyte (CTL) and T-helper epitopes within reverse transcriptase (RT) of HIV-1 subtype C from Ethiopia and Botswana following selection of antiretroviral drug resistance. Antiviral Research. 56: 129-42. PMID 12367719 DOI: 10.1016/S0166-3542(02)00100-6 |
0.355 |
|
| 2002 |
Loemba H, Brenner B, Parniak MA, Ma'ayan S, Spira B, Moisi D, Oliveira M, Detorio M, Essex M, Wainberg MA. Co-receptor usage and HIV-1 intra-clade C polymorphisms in the protease and reverse transcriptase genes of HIV-1 isolates from Ethiopia and Botswana. Antiviral Therapy. 7: 141-8. PMID 12212926 |
0.348 |
|
| 2002 |
Borkow G, Salomon H, Wainberg MA, Parniak MA. Attenuated infectivity of HIV type 1 from epithelial cells pretreated with a tight-binding nonnucleoside reverse transcriptase inhibitor. Aids Research and Human Retroviruses. 18: 711-4. PMID 12167278 DOI: 10.1089/088922202760072339 |
0.488 |
|
| 2002 |
Sluis-Cremer N, Arion D, Parniak MA. Destabilization of the HIV-1 reverse transcriptase dimer upon interaction with N-acyl hydrazone inhibitors. Molecular Pharmacology. 62: 398-405. PMID 12130693 DOI: 10.1124/Mol.62.2.398 |
0.558 |
|
| 2002 |
Lok CN, Viazovkina E, Min KL, Nagy E, Wilds CJ, Damha MJ, Parniak MA. Potent gene-specific inhibitory properties of mixed-backbone antisense oligonucleotides comprised of 2'-deoxy-2'-fluoro-D-arabinose and 2'-deoxyribose nucleotides. Biochemistry. 41: 3457-67. PMID 11876654 DOI: 10.1021/Bi0115075 |
0.346 |
|
| 2002 |
Arion D, Sluis-Cremer N, Min KL, Abram ME, Fletcher RS, Parniak MA. Mutational analysis of Tyr-501 of HIV-1 reverse transcriptase. Effects on ribonuclease H activity and inhibition of this activity by N-acylhydrazones. The Journal of Biological Chemistry. 277: 1370-4. PMID 11684697 DOI: 10.1074/jbc.M110254200 |
0.752 |
|
| 2001 |
Pelemans H, Esnouf R, Min KL, Parniak M, De Clercq E, Balzarini J. Mutations at amino acid positions 63, 189, and 396 of human immunodeficiency virus type 1 reverse transcriptase (RT) partially restore the DNA polymerase activity of a Trp229Tyr mutant RT. Virology. 287: 143-50. PMID 11504549 DOI: 10.1006/Viro.2001.1032 |
0.43 |
|
| 2001 |
Parniak MA. Nonnucleoside reverse transcriptase inhibitors as anti-HIV-1 microbicides Aids. 15: S56. DOI: 10.1097/00002030-200102001-00079 |
0.49 |
|
| 2000 |
Sluis-Cremer N, Arion D, Parniak MA. Molecular mechanisms of HIV-1 resistance to nucleoside reverse transcriptase inhibitors (NRTIs) Cellular and Molecular Life Sciences. 57: 1408-1422. PMID 11078020 |
0.456 |
|
| 2000 |
Parniak MA, Sluis-Cremer N. Inhibitors of HIV-1 reverse transcriptase Advances in Pharmacology (San Diego, Calif.). 49: 67-109. PMID 11013761 |
0.414 |
|
| 2000 |
Khorchid A, Javanbakht H, Wise S, Halwani R, Parniak MA, Wainberg MA, Kleiman L. Sequences within Pr160gag-pol affecting the selective packaging of primer tRNA(Lys3) into HIV-1. Journal of Molecular Biology. 299: 17-26. PMID 10860720 DOI: 10.1006/Jmbi.2000.3709 |
0.394 |
|
| 2000 |
Shah FS, Curr KA, Hamburgh ME, Parniak M, Mitsuya H, Arnez JG, Prasad VR. Differential influence of nucleoside analog-resistance mutations K65R and L74V on the overall mutation rate and error specificity of human immunodeficiency virus type 1 reverse transcriptase. The Journal of Biological Chemistry. 275: 27037-44. PMID 10833521 DOI: 10.1074/Jbc.M002881200 |
0.364 |
|
| 2000 |
Sluis-Cremer N, Arion D, Kaushik N, Lim H, Parniak MA. Mutational analysis of Lys65 of HIV-1 reverse transcriptase Biochemical Journal. 348: 77-82. PMID 10794716 DOI: 10.1042/0264-6021:3480077 |
0.361 |
|
| 2000 |
Arion D, Sluis-Cremer N, Parniak MA. Mechanism by which phosphonoformic acid resistance mutations restore 3'- azido-3'-deoxythymidine (AZT) sensitivity to AZT-resistant HIV-1 reverse transcriptase Journal of Biological Chemistry. 275: 9251-9255. PMID 10734063 DOI: 10.1074/jbc.275.13.9251 |
0.315 |
|
| 2000 |
Sluis-Cremer N, Dmitrienko GI, Balzarini J, Camarasa MJ, Parniak MA. Human immunodeficiency virus type 1 reverse transcriptase dimer destabilization by 1-{spiro[4'-amino-2',2'-dioxo- 1',2'-oxathiole-5',3'- [2',5'-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]]}-3-ethylthymine Biochemistry. 39: 1427-1433. PMID 10684624 DOI: 10.1021/Bi991682+ |
0.515 |
|
| 1999 |
Arion D, Parniak MA. HIV resistance to zidovudine: the role of pyrophosphorolysis. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 2: 91-95. PMID 11504476 DOI: 10.1054/drup.1999.0076 |
0.386 |
|
| 1999 |
Quan Y, Motakis D, Buckheit R, Xu ZQ, Flavin MT, Parniak MA, Wainberg MA. Sensitivity and resistance to (+)-calanolide A of wild-type and mutated forms of HIV-1 reverse transcriptase. Antiviral Therapy. 4: 203-9. PMID 10723499 |
0.412 |
|
| 1999 |
Borkow G, Arion D, Wainberg MA, Parniak MA. The thiocarboxanilide nonnucleoside inhibitor UC781 restores antiviral activity of 3'-azido-3'-deoxythymidine (AZT) against AZT-resistant human immunodeficiency virus type 1. Antimicrobial Agents and Chemotherapy. 43: 259-63. PMID 9925515 DOI: 10.1128/Aac.43.2.259 |
0.406 |
|
| 1999 |
Borkow G, Arion D, Wainberg MA, Parniak MA. The Thiocarboxanilide Nonnucleoside Inhibitor UC781 Restores Antiviral Activity of 3′-Azido-3′-Deoxythymidine (AZT) against AZT-Resistant Human Immunodeficiency Virus Type 1 Antimicrobial Agents and Chemotherapy. 43: 259-263. DOI: 10.1128/aac.43.2.259 |
0.403 |
|
| 1998 |
Arion D, Kaushik N, McCormick S, Borkow G, Parniak MA. Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase. Biochemistry. 37: 15908-17. PMID 9843396 DOI: 10.1021/Bi981200E |
0.465 |
|
| 1998 |
Balzarini J, Naesens L, Verbeken E, Laga M, Van Damme L, Parniak M, Van Mellaert L, Anné J, De Clercq E. Preclinical studies on thiocarboxanilide UC-781 as a virucidal agent Aids. 12: 1129-1138. PMID 9677161 DOI: 10.1097/00002030-199810000-00004 |
0.407 |
|
| 1998 |
Pelemans H, Esnouf RM, Parniak MA, Vandamme AM, De Clercq E, Balzarini J. A proline-to-histidine substitution at position 225 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) sensitizes HIV-1 RT to BHAP U-90152. The Journal of General Virology. 79: 1347-52. PMID 9634074 DOI: 10.1099/0022-1317-79-6-1347 |
0.447 |
|
| 1997 |
Borkow G, Arion D, Noronha A, Scartozzi M, Damha MJ, Parniak MA. Inhibitory potency of R-region specific antisense oligonucleotides against in vitro DNA polymerization and template-switching reactions catalysed by HIV-1 reverse transcriptase. The International Journal of Biochemistry & Cell Biology. 29: 1285-95. PMID 9451826 DOI: 10.1016/S1357-2725(97)00067-8 |
0.36 |
|
| 1997 |
Pelemans H, Esnouf R, Dunkler A, Parniak MA, Vandamme AM, Karlsson A, De Clercq E, Kleim JP, Balzarini J. Characteristics of the Pro225His mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase that appears under selective pressure of dose-escalating quinoxaline treatment of HIV-1. Journal of Virology. 71: 8195-203. PMID 9343170 DOI: 10.1128/Jvi.71.11.8195-8203.1997 |
0.502 |
|
| 1997 |
Li X, Liang C, Quan Y, Chandok R, Laughrea M, Parniak MA, Kleiman L, Wainberg MA. Identification of sequences downstream of the primer binding site that are important for efficient replication of human immunodeficiency virus type 1. Journal of Virology. 71: 6003-10. PMID 9223491 DOI: 10.1128/Jvi.71.8.6003-6010.1997 |
0.304 |
|
| 1997 |
Barnard J, Borkow G, Parniak MA. The thiocarboxanilide nonnucleoside UC781 is a tight-binding inhibitor of HIV-1 reverse transcriptase. Biochemistry. 36: 7786-92. PMID 9201921 DOI: 10.1021/Bi970140U |
0.448 |
|
| 1997 |
Borkow G, Fletcher RS, Barnard J, Arion D, Motakis D, Dmitrienko GI, Parniak MA. Inhibition of the ribonuclease H and DNA polymerase activities of HIV-1 reverse transcriptase by N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone. Biochemistry. 36: 3179-85. PMID 9115994 DOI: 10.1021/Bi9624696 |
0.543 |
|
| 1997 |
Borkow G, Barnard J, Nguyen TM, Belmonte A, Wainberg MA, Parniak MA. Chemical barriers to human immunodeficiency virus type 1 (HIV-1) infection: retrovirucidal activity of UC781, a thiocarboxanilide nonnucleoside inhibitor of HIV-1 reverse transcriptase. Journal of Virology. 71: 3023-30. PMID 9060662 DOI: 10.1128/Jvi.71.4.3023-3030.1997 |
0.418 |
|
| 1997 |
Mak J, Khorchid A, Cao Q, Huang Y, Lowy I, Parniak MA, Prasad VR, Wainberg MA, Kleiman L. Effects of mutations in Pr160gag-pol upon tRNA(Lys3) and Pr160gag-plo incorporation into HIV-1. Journal of Molecular Biology. 265: 419-31. PMID 9034361 DOI: 10.1006/Jmbi.1996.0742 |
0.37 |
|
| 1997 |
Borkow G, Barnard J, Nguyen TM, Belmonte A, Wainberg MA, Parniak MA. Chemical barriers to human immunodeficiency virus type 1 (HIV-1) infection: retrovirucidal activity of UC781, a thiocarboxanilide nonnucleoside inhibitor of HIV-1 reverse transcriptase. Journal of Virology. 71: 3023-3030. DOI: 10.1128/jvi.71.4.3023-3030.1997 |
0.428 |
|
| 1996 |
Fletcher RS, Holleschak G, Nagy E, Arion D, Borkow G, Gu Z, Wainberg MA, Parniak MA. Single-step purification of recombinant wild-type and mutant HIV-1 reverse transcriptase. Protein Expression and Purification. 7: 27-32. PMID 9172779 DOI: 10.1006/Prep.1996.0004 |
0.346 |
|
| 1996 |
Wainberg MA, Hsu M, Gu Z, Borkow G, Parniak MA. Effectiveness of 3TC in HIV clinical trials may be due in part to the M184V substitution in 3TC-resistant HIV-1 reverse transcriptase. Aids (London, England). 10: S3-10. PMID 9030390 DOI: 10.1097/00002030-199612005-00002 |
0.477 |
|
| 1996 |
Arion D, Fletcher RS, Borkow G, Camarasa MJ, Balzarini J, Dmitrienko GI, Parniak MA. Differences in the inhibition of human immunodeficiency virus type 1 reverse transcriptase DNA polymerase activity by analogs of nevirapine and [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1", 2"-oxathiole-2",2"-dioxide] (TSAO). Molecular Pharmacology. 50: 1057-64. PMID 8913335 |
0.432 |
|
| 1996 |
Arion D, Harada R, Li X, Wainberg MA, Parniak MA. HIV-1 reverse transcriptase shows no specificity for the binding of primer tRNA(Lys3). Biochemical and Biophysical Research Communications. 225: 839-43. PMID 8780699 DOI: 10.1006/Bbrc.1996.1260 |
0.339 |
|
| 1996 |
Arion D, Borkow G, Gu Z, Wainberg MA, Parniak MA. The K65R mutation confers increased DNA polymerase processivity to HIV-1 reverse transcriptase. The Journal of Biological Chemistry. 271: 19860-4. PMID 8702696 DOI: 10.1074/Jbc.271.33.19860 |
0.348 |
|
| 1996 |
Gu Z, Li X, Quan Y, Parniak MA, Wainberg MA. Studies of neutralizing monoclonal antibody to human immunodeficiency virus type 1 reverse transcriptase: antagonistic and synergistic effects in reactions performed in the presence of nucleoside and nonnucleoside inhibitors, respectively. Journal of Virology. 70: 2620-6. PMID 8642696 DOI: 10.1128/Jvi.70.4.2620-2626.1996 |
0.378 |
|
| 1996 |
Wainberg MA, Drosopoulos WC, Salomon H, Hsu M, Borkow G, Parniak M, Gu Z, Song Q, Manne J, Islam S, Castriota G, Prasad VR. Enhanced fidelity of 3TC-selected mutant HIV-1 reverse transcriptase. Science (New York, N.Y.). 271: 1282-5. PMID 8638110 DOI: 10.1126/Science.271.5253.1282 |
0.428 |
|
| 1995 |
Fletcher RS, Arion D, Borkow G, Wainberg MA, Dmitrienko GI, Parniak MA. Synergistic inhibition of HIV-1 reverse transcriptase DNA polymerase activity and virus replication in vitro by combinations of carboxanilide nonnucleoside compounds. Biochemistry. 34: 10106-12. PMID 7543775 DOI: 10.1021/Bi00032A002 |
0.516 |
|
| 1995 |
Wainberg MA, Gu Z, Salomon H, Arts EJ, Kleiman L, Parniak MA, Morin N. Molecular basis and clinical significance of HIV-1 resistance to nucleoside compounds Comptes Rendus De L"Academie Des Sciences. Serie Iii, Sciences De La Vie. 318: 315-328. PMID 7540494 |
0.39 |
|
| 1995 |
Gu Z, Arts EJ, Parniak MA, Wainberg MA. Mutated K65R recombinant reverse transcriptase of human immunodeficiency virus type 1 shows diminished chain termination in the presence of 2′,3′-dideoxycytidine 5′-triphosphate and other drugs Proceedings of the National Academy of Sciences of the United States of America. 92: 2760-2764. PMID 7535930 DOI: 10.1073/Pnas.92.7.2760 |
0.434 |
|
| 1995 |
Fletcher RS, Syed K, Mithani S, Dmitrienko GI, Parniak MA. Carboxanilide derivative non-nucleoside inhibitors of HIV-1 reverse transcriptase interact with different mechanistic forms of the enzyme. Biochemistry. 34: 4346-53. PMID 7535561 DOI: 10.1021/Bi00013A025 |
0.465 |
|
| 1994 |
Gao Q, Gu Z, Salomon H, Nagai K, Parniak MA, Wainberg MA. Generation of multiple drug resistance by sequential in vitro passage of the human immunodeficiency virus type 1. Archives of Virology. 136: 111-22. PMID 8002779 DOI: 10.1007/Bf01538821 |
0.306 |
|
| 1994 |
Gu Z, Fletcher RS, Arts EJ, Wainberg MA, Parniak MA. The K65R mutant reverse transcriptase of HIV-1 cross-resistant to 2′,3′-dideoxycytidine, 2′,3′-dideoxy-3′-thiacytidine, and 2′,3′-dideoxyinosine shows reduced sensitivity to specific dideoxynucleoside triphosphate inhibitors in vitro Journal of Biological Chemistry. 269: 28118-28122. PMID 7525567 |
0.412 |
|
| 1994 |
Li X, Mak J, Arts EJ, Gu Z, Kleiman L, Wainberg MA, Parniak MA. Effects of alterations of primer-binding site sequences on human immunodeficiency virus type 1 replication Journal of Virology. 68: 6198-6206. PMID 7521916 DOI: 10.1128/Jvi.68.10.6198-6206.1994 |
0.375 |
|
| 1993 |
Li X, Gu Z, Geleziunas R, Kleiman L, Wainberg MA, Parniak MA. Expression, purification, and RNA-binding properties of HIV-1 p15gag nucleocapsid protein. Protein Expression and Purification. 4: 304-11. PMID 8374299 DOI: 10.1006/Prep.1993.1039 |
0.312 |
|
| 1993 |
Wu J, Amandoron E, Li X, Wainberg MA, Parniak MA. Monoclonal antibody-mediated inhibition of HIV-1 reverse transcriptase polymerase activity. Interaction with a possible deoxynucleoside triphosphate binding domain. The Journal of Biological Chemistry. 268: 9980-5. PMID 7683687 |
0.41 |
|
| 1993 |
Li X, Amandoron E, Wainberg MA, Parniak MA. Generation and characterization of murine monoclonal antibodies reactive against N-terminal and other regions of HIV-1 reverse transcriptase. Journal of Medical Virology. 39: 251-9. PMID 7682257 DOI: 10.1002/Jmv.1890390314 |
0.385 |
|
| 1992 |
Gao Q, Gu ZX, Parniak MA, Li XG, Wainberg MA. In vitro selection of variants of human immunodeficiency virus type 1 resistant to 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine. Journal of Virology. 66: 12-9. PMID 1727474 DOI: 10.1128/Jvi.66.1.12-19.1992 |
0.329 |
|
| 1992 |
Jiang M, Mak J, Wainberg MA, Parniak MA, Cohen E, Kleiman L. Variable tRNA content in HIV-1IIIB. Biochemical and Biophysical Research Communications. 185: 1005-15. PMID 1627125 DOI: 10.1016/0006-291X(92)91727-8 |
0.372 |
|
| 1992 |
Yao XJ, Wainberg MA, Parniak MA. Mechanism of inhibition of HIV-1 infection in vitro by purified extract of Prunella vulgaris. Virology. 187: 56-62. PMID 1371029 DOI: 10.1016/0042-6822(92)90294-Y |
0.394 |
|
| 1991 |
Wainberg MA, Rooke R, Tremblay M, Li X, Parniak MA, Gao Q, Yao XJ, Tsoukas C, Montaner J, Fanning M, Ruedy J. Clinical significance and characterization of AZT-resistant strains of HIV-1. The Canadian Journal of Infectious Diseases = Journal Canadien Des Maladies Infectieuses. 2: 5-11. PMID 22451746 DOI: 10.1155/1991/124860 |
0.449 |
|
| 1991 |
Kleiman L, Caudry S, Boulerice F, Wainberg MA, Parniak MA. Incorporation of tRNA into normal and mutant HIV-1. Biochemical and Biophysical Research Communications. 174: 1272-80. PMID 1705120 DOI: 10.1016/0006-291X(91)91559-U |
0.361 |
|
| 1991 |
Rooke R, Parniak MA, Tremblay M, Soudeyns H, Li XG, Gao Q, Yao XJ, Wainberg MA. Biological comparison of wild-type and zidovudine-resistant isolates of human immunodeficiency virus type 1 from the same subjects: susceptibility and resistance to other drugs. Antimicrobial Agents and Chemotherapy. 35: 988-91. PMID 1649576 DOI: 10.1128/Aac.35.5.988 |
0.343 |
|
| 1990 |
Wainberg MA, Tremblay M, Rooke R, Blain N, Soudeyns H, Parniak MA, Yao XJ, Li XG, Fanning M, Montaner JSG, O'Shaughnessy M, Tsoukas C, Falutz J, Dionne G, Belleau B, et al. Characterization of reverse transcriptase activity and susceptibility to other nucleosides of AZT-resistant variants of HIV-1: Results from the Canadian AZT Multicentre study Annals of the New York Academy of Sciences. 616: 346-355. PMID 1706573 DOI: 10.1111/J.1749-6632.1990.Tb17855.X |
0.391 |
|
| 1984 |
Phillips RS, Parniak MA, Kaufman S. Spectroscopic investigation of ligand interaction with hepatic phenylalanine hydroxylase: evidence for a conformational change associated with activation. Biochemistry. 23: 3836-42. PMID 6487579 DOI: 10.1021/Bi00312A007 |
0.306 |
|
| 1984 |
Jackson GE, Parniak MA, Murray GJ, Viswanatha T. Stimulation by glutamine of the formation of N6-hydroxylysine in a cell-free extract from Aerobacter aerogenes 62-1 Journal of Cellular Biochemistry. 24: 395-403. PMID 6432805 DOI: 10.1002/jcb.240240409 |
0.55 |
|
| 1983 |
Parniak MA, Lange G, Viswanatha T. Quantitative determination of monosubstituted guanidines: A comparative study of different procedures Journal of Biochemical and Biophysical Methods. 7: 267-276. PMID 6619504 DOI: 10.1016/0165-022X(83)90051-9 |
0.505 |
|
| 1979 |
Parniak MA, Jackson GED, Murray GJ, Viswanatha T. Studies on the formation of N6-hydroxylysine in cell-free extracts of Aerobacter aerogenes 62-1 Bba - Enzymology. 569: 99-108. PMID 465510 DOI: 10.1016/0005-2744(79)90085-8 |
0.519 |
|
| 1977 |
Murray GJ, Clark GED, Parniak MA, Viswanatha T. Effect of metabolites on ε N hydroxylysine formation in cell free extracts of Aerobacter aerogenes 62 1 Canadian Journal of Biochemistry. 55: 625-629. PMID 18266 DOI: 10.1139/o77-090 |
0.524 |
|
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