| Year |
Citation |
Score |
| 2019 |
Burke JR, La Clair JJ, Philippe RN, Pabis A, Corbella M, Jez JM, Cortina GA, Kaltenbach M, Bowman ME, Louie GV, Woods KB, Nelson AT, Tawfik DS, Kamerlin SC, Noel JP. Bifunctional Substrate Activation via an Arginine Residue Drives Catalysis in Chalcone Isomerases Acs Catalysis. 9: 8388-8396. DOI: 10.1021/Acscatal.9B01926 |
0.63 |
|
| 2018 |
Kaltenbach M, Burke JR, Dindo M, Pabis A, Munsberg FS, Rabin A, Kamerlin SCL, Noel JP, Tawfik DS. Evolution of chalcone isomerase from a noncatalytic ancestor. Nature Chemical Biology. PMID 29686356 DOI: 10.1038/S41589-018-0042-3 |
0.343 |
|
| 2016 |
Smock RG, Yadid I, Dym O, Clarke J, Tawfik DS. De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints. Cell. PMID 26806127 DOI: 10.1016/J.Cell.2015.12.024 |
0.735 |
|
| 2015 |
Dellus-Gur E, Elias M, Caselli E, Prati F, Salverda ML, de Visser JA, Fraser JS, Tawfik DS. Negative Epistasis and Evolvability in TEM-1 β-Lactamase-The Thin Line between an Enzyme's Conformational Freedom and Disorder. Journal of Molecular Biology. 427: 2396-409. PMID 26004540 DOI: 10.1016/J.Jmb.2015.05.011 |
0.336 |
|
| 2015 |
Ben-David M, Sussman JL, Maxwell CI, Szeler K, Kamerlin SC, Tawfik DS. Catalytic stimulation by restrained active-site floppiness--the case of high density lipoprotein-bound serum paraoxonase-1. Journal of Molecular Biology. 427: 1359-74. PMID 25644661 DOI: 10.1016/J.Jmb.2015.01.013 |
0.653 |
|
| 2013 |
Dellus-Gur E, Toth-Petroczy A, Elias M, Tawfik DS. What makes a protein fold amenable to functional innovation? Fold polarity and stability trade-offs. Journal of Molecular Biology. 425: 2609-21. PMID 23542341 DOI: 10.1016/j.jmb.2013.03.033 |
0.348 |
|
| 2013 |
Tóth-Petróczy A, Tawfik DS. Protein insertions and deletions enabled by neutral roaming in sequence space. Molecular Biology and Evolution. 30: 761-71. PMID 23315956 DOI: 10.1093/molbev/mst003 |
0.33 |
|
| 2012 |
Tokuriki N, Jackson CJ, Afriat-Jurnou L, Wyganowski KT, Tang R, Tawfik DS. Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme. Nature Communications. 3: 1257. PMID 23212386 DOI: 10.1038/Ncomms2246 |
0.306 |
|
| 2012 |
Afriat-Jurnou L, Jackson CJ, Tawfik DS. Reconstructing a missing link in the evolution of a recently diverged phosphotriesterase by active-site loop remodeling. Biochemistry. 51: 6047-55. PMID 22809311 DOI: 10.1021/Bi300694T |
0.313 |
|
| 2011 |
Yadid I, Tawfik DS. Functional β-propeller lectins by tandem duplications of repetitive units. Protein Engineering, Design & Selection : Peds. 24: 185-95. PMID 20713410 DOI: 10.1093/Protein/Gzq053 |
0.724 |
|
| 2010 |
Soskine M, Tawfik DS. Mutational effects and the evolution of new protein functions. Nature Reviews. Genetics. 11: 572-82. PMID 20634811 DOI: 10.1038/nrg2808 |
0.3 |
|
| 2010 |
Yadid I, Kirshenbaum N, Sharon M, Dym O, Tawfik DS. Metamorphic proteins mediate evolutionary transitions of structure. Proceedings of the National Academy of Sciences of the United States of America. 107: 7287-92. PMID 20368465 DOI: 10.1073/Pnas.0912616107 |
0.731 |
|
| 2010 |
Gaidukov L, Viji RI, Yacobson S, Rosenblat M, Aviram M, Tawfik DS. ApoE induces serum paraoxonase PON1 activity and stability similar to ApoA-I. Biochemistry. 49: 532-8. PMID 20025294 DOI: 10.1021/Bi9013227 |
0.7 |
|
| 2009 |
Gaidukov L, Bar D, Yacobson S, Naftali E, Kaufman O, Tabakman R, Tawfik DS, Levy-Nissenbaum E. In vivo administration of BL-3050: highly stable engineered PON1-HDL complexes. Bmc Clinical Pharmacology. 9: 18. PMID 19922610 DOI: 10.1186/1472-6904-9-18 |
0.662 |
|
| 2009 |
Tokuriki N, Tawfik DS. Chaperonin overexpression promotes genetic variation and enzyme evolution. Nature. 459: 668-73. PMID 19494908 DOI: 10.1038/nature08009 |
0.343 |
|
| 2009 |
Khersonsky O, Rosenblat M, Toker L, Yacobson S, Hugenmatter A, Silman I, Sussman JL, Aviram M, Tawfik DS. Directed evolution of serum paraoxonase PON3 by family shuffling and ancestor/consensus mutagenesis, and its biochemical characterization Biochemistry. 48: 6644-6654. PMID 19492856 DOI: 10.1021/Bi900583Y |
0.364 |
|
| 2008 |
Bershtein S, Tawfik DS. Ohno's model revisited: measuring the frequency of potentially adaptive mutations under various mutational drifts. Molecular Biology and Evolution. 25: 2311-8. PMID 18687656 DOI: 10.1093/Molbev/Msn174 |
0.663 |
|
| 2008 |
Bershtein S, Goldin K, Tawfik DS. Intense neutral drifts yield robust and evolvable consensus proteins. Journal of Molecular Biology. 379: 1029-44. PMID 18495157 DOI: 10.1016/J.Jmb.2008.04.024 |
0.688 |
|
| 2008 |
Tokuriki N, Stricher F, Serrano L, Tawfik DS. How protein stability and new functions trade off. Plos Computational Biology. 4: e1000002. PMID 18463696 DOI: 10.1371/Journal.Pcbi.1000002 |
0.326 |
|
| 2008 |
Bershtein S, Tawfik DS. Advances in laboratory evolution of enzymes. Current Opinion in Chemical Biology. 12: 151-8. PMID 18284924 DOI: 10.1016/J.Cbpa.2008.01.027 |
0.658 |
|
| 2007 |
Amitai G, Gupta RD, Tawfik DS. Latent evolutionary potentials under the neutral mutational drift of an enzyme. Hfsp Journal. 1: 67-78. PMID 19404461 DOI: 10.2976/1.2739115/10.2976/1 |
0.31 |
|
| 2007 |
Gaidukov L, Tawfik DS. The development of human sera tests for HDL-bound serum PON1 and its lipolactonase activity. Journal of Lipid Research. 48: 1637-46. PMID 17435182 DOI: 10.1194/Jlr.D600045-Jlr200 |
0.673 |
|
| 2007 |
Yadid I, Tawfik DS. Reconstruction of functional beta-propeller lectins via homo-oligomeric assembly of shorter fragments. Journal of Molecular Biology. 365: 10-7. PMID 17054983 DOI: 10.1016/J.Jmb.2006.09.055 |
0.736 |
|
| 2006 |
Bershtein S, Segal M, Bekerman R, Tokuriki N, Tawfik DS. Robustness-epistasis link shapes the fitness landscape of a randomly drifting protein. Nature. 444: 929-32. PMID 17122770 DOI: 10.1038/Nature05385 |
0.687 |
|
| 2006 |
Gaidukov L, Rosenblat M, Aviram M, Tawfik DS. The 192R/Q polymorphs of serum paraoxonase PON1 differ in HDL binding, lipolactonase stimulation, and cholesterol efflux. Journal of Lipid Research. 47: 2492-502. PMID 16914770 DOI: 10.1194/Jlr.M600297-Jlr200 |
0.673 |
|
| 2006 |
Amitai G, Gaidukov L, Adani R, Yishay S, Yacov G, Kushnir M, Teitlboim S, Lindenbaum M, Bel P, Khersonsky O, Tawfik DS, Meshulam H. Enhanced stereoselective hydrolysis of toxic organophosphates by directly evolved variants of mammalian serum paraoxonase. The Febs Journal. 273: 1906-19. PMID 16640555 DOI: 10.1111/J.1742-4658.2006.05198.X |
0.664 |
|
| 2006 |
Rosenblat M, Gaidukov L, Khersonsky O, Vaya J, Oren R, Tawfik DS, Aviram M. The catalytic histidine dyad of high density lipoprotein-associated serum paraoxonase-1 (PON1) is essential for PON1-mediated inhibition of low density lipoprotein oxidation and stimulation of macrophage cholesterol efflux. The Journal of Biological Chemistry. 281: 7657-65. PMID 16407304 DOI: 10.1074/Jbc.M512595200 |
0.665 |
|
| 2006 |
Sussman J, Aharoni A, Harel M, Gaidukov L, Brumshtein B, Khersonsky O, Yagur S, Toker L, Silman I, Tawfik D. 3D structure of mammalian paraoxonase at 2.2Å resolution Toxicology Letters. 164: S9. DOI: 10.1016/J.Toxlet.2006.06.024 |
0.645 |
|
| 2005 |
Roodveldt C, Tawfik DS. Shared promiscuous activities and evolutionary features in various members of the amidohydrolase superfamily. Biochemistry. 44: 12728-36. PMID 16171387 DOI: 10.1021/bi051021e |
0.306 |
|
| 2005 |
Gaidukov L, Tawfik DS. High affinity, stability, and lactonase activity of serum paraoxonase PON1 anchored on HDL with ApoA-I. Biochemistry. 44: 11843-54. PMID 16128586 DOI: 10.1021/Bi050862I |
0.694 |
|
| 2005 |
Gould SM, Tawfik DS. Directed evolution of the promiscuous esterase activity of carbonic anhydrase II. Biochemistry. 44: 5444-52. PMID 15807537 DOI: 10.1021/bi0475471 |
0.324 |
|
| 2005 |
Aharoni A, Gaidukov L, Khersonsky O, McQ Gould S, Roodveldt C, Tawfik DS. The 'evolvability' of promiscuous protein functions. Nature Genetics. 37: 73-6. PMID 15568024 DOI: 10.1038/Ng1482 |
0.697 |
|
| 2004 |
Harel M, Aharoni A, Gaidukov L, Brumshtein B, Khersonsky O, Meged R, Dvir H, Ravelli RB, McCarthy A, Toker L, Silman I, Sussman JL, Tawfik DS. Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes. Nature Structural & Molecular Biology. 11: 412-9. PMID 15098021 DOI: 10.1038/Nsmb767 |
0.692 |
|
| 2004 |
Aharoni A, Gaidukov L, Yagur S, Toker L, Silman I, Tawfik DS. Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization. Proceedings of the National Academy of Sciences of the United States of America. 101: 482-7. PMID 14695884 DOI: 10.1073/Pnas.2536901100 |
0.694 |
|
| 2004 |
Harel M, Aharoni A, Gaidukov L, Brumshtein B, Khersonsky O, Meged R, Dvir H, Ravelli RBG, McCarthy A, Toker L, Silman I, Sussman JL, Tawfik DS. Erratum: Corrigendum: Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes Nature Structural & Molecular Biology. 11: 1253-1253. DOI: 10.1038/Nsmb1204-1253A |
0.7 |
|
| 2001 |
James LC, Tawfik DS. Catalytic and binding poly-reactivities shared by two unrelated proteins: The potential role of promiscuity in enzyme evolution Protein Science. 10: 2600-2607. PMID 11714928 DOI: 10.1110/ps.ps.14601 |
0.331 |
|
| 1996 |
Knossow M, Charbonnier J, Gigant B, Golinelli B, Tawfik D, Eshhar Z, Green BS. Structural studies of catalytic antibodies with esterase activity Acta Crystallographica Section a Foundations of Crystallography. 52: C216-C216. DOI: 10.1107/S0108767396090708 |
0.303 |
|
| 1994 |
Golinelli-Pimpaneau B, Gigant B, Bizebard T, Navaza J, Saludjian P, Zemel R, Tawfik D, Eshhar Z, Green B, Knossow M. Crystal structure of a catalytic antibody Fab with esterase- like activity Structure. 2: 175-183. PMID 8069632 DOI: 10.1016/S0969-2126(00)00019-8 |
0.309 |
|
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