| Year |
Citation |
Score |
| 2022 |
Sule A, Golding SE, Ahmad SF, Watson J, Ahmed MH, Kellogg GE, Bernas T, Koebley S, Reed JC, Povirk LF, Valerie K. ATM phosphorylates PP2A subunit A resulting in nuclear export and spatiotemporal regulation of the DNA damage response. Cellular and Molecular Life Sciences : Cmls. 79: 603. PMID 36434396 DOI: 10.1007/s00018-022-04550-5 |
0.751 |
|
| 2020 |
Allen J, Wang J, Zolotarskaya OY, Sule A, Mohammad S, Arslan S, Wynne K, Yang H, Valerie K. PEAMOtecan, a novel chronotherapeutic polymeric drug for brain cancer. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 32027939 DOI: 10.1016/J.Jconrel.2020.02.003 |
0.322 |
|
| 2018 |
Kawale AS, Akopiants K, Valerie K, Ruis B, Hendrickson EA, Huang SN, Pommier Y, Povirk LF. TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining. Nucleic Acids Research. PMID 30113698 DOI: 10.1093/Nar/Gky694 |
0.46 |
|
| 2018 |
Durant ST, Zheng L, Wang Y, Chen K, Zhang L, Zhang T, Yang Z, Riches L, Trinidad AG, Fok JHL, Hunt T, Pike KG, Wilson J, Smith A, Colclough N, ... ... Valerie K, et al. The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models. Science Advances. 4: eaat1719. PMID 29938225 DOI: 10.1126/Sciadv.Aat1719 |
0.454 |
|
| 2018 |
Karlin J, Allen J, Ahmad SF, Hughes G, Sheridan V, Odedra R, Farrington P, Cadogan EB, Riches LC, Garcia-Trinidad A, Thomason AG, Patel B, Vincent J, Lau A, Pike KG, ... ... Valerie K, et al. Orally bioavailable and blood-brain-barrier penetrating ATM inhibitor (AZ32) radiosensitizes intracranial gliomas in mice. Molecular Cancer Therapeutics. PMID 29769307 DOI: 10.1158/1535-7163.Mct-17-0975 |
0.468 |
|
| 2018 |
Durant ST, Pike KG, Colclough N, Riches L, Garcia-Trinidad A, Hunt T, Ling S, Stott J, Barrett I, Zheng L, Wang Y, Chen K, Zhang T, Reddy VP, Sykes A, ... ... Valerie K, et al. Abstract A104: AZD1390, a potent and selective orally bioavailable blood-brain barrier-penetrant ATM inhibitor, radiosensitizes and improves survival of orthotopic glioma and metastatic brain tumor models Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-A104 |
0.425 |
|
| 2017 |
Beckta JM, Adams BR, Valerie K. DNA Damage Response in Human Stem Cells and Neural Descendants. Methods in Molecular Biology (Clifton, N.J.). 1599: 375-390. PMID 28477133 DOI: 10.1007/978-1-4939-6955-5_27 |
0.448 |
|
| 2017 |
Kahn J, Allen J, Karlin J, Ahmad S, Sule A, Tokarz M, Henderson A, Mukhopadhyay N, Pike K, Colclough N, Pass M, Durant S, Valerie K. Next-Generation ATM Kinase Inhibitors Under Development Radiosensitize Glioblastoma With Conformal Radiation in a Mouse Orthotopic Model International Journal of Radiation Oncology*Biology*Physics. 99: E600-E601. DOI: 10.1016/J.Ijrobp.2017.06.2046 |
0.377 |
|
| 2016 |
Beckta JM, Dever SM, Gnawali N, Khalil A, Sule A, Golding SE, Rosenberg E, Narayanan A, Kehn-Hall K, Xu B, Povirk LF, Valerie K. Correction: Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining. Oncotarget. 7: 58716. PMID 28039444 DOI: 10.18632/oncotarget.11846 |
0.645 |
|
| 2016 |
Kegelman TP, Wu B, Das SK, Talukdar S, Beckta JM, Hu B, Emdad L, Valerie K, Sarkar D, Furnari FB, Cavenee WK, Wei J, Purves A, De SK, Pellecchia M, et al. Inhibition of radiation-induced glioblastoma invasion by genetic and pharmacological targeting of MDA-9/Syntenin. Proceedings of the National Academy of Sciences of the United States of America. PMID 28011764 DOI: 10.1073/Pnas.1616100114 |
0.441 |
|
| 2016 |
Durant ST, Karlin J, Pike K, Colclough N, Mukhopadhyay N, Ahmad SF, Bekta JM, Tokarz M, Bardelle C, Hughes G, Patel B, Thomason A, Cadogan E, Barrett I, Lau A, ... ... Valerie K, et al. Abstract 3041: Blood-brain barrier penetrating ATM inhibitor (AZ32) radiosensitises intracranial gliomas in mice Cancer Research. 76: 3041-3041. DOI: 10.1158/1538-7445.Am2016-3041 |
0.493 |
|
| 2015 |
Beckta JM, Dever SM, Gnawali N, Khalil A, Sule A, Golding SE, Rosenberg E, Narayanan A, Kehn-Hall K, Xu B, Povirk LF, Valerie K. Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining. Oncotarget. PMID 26320175 DOI: 10.18632/Oncotarget.4876 |
0.732 |
|
| 2015 |
Guendel I, Meltzer BW, Baer A, Dever SM, Valerie K, Guo J, Wu Y, Kehn-Hall K. BRCA1 functions as a novel transcriptional cofactor in HIV-1 infection. Virology Journal. 12: 40. PMID 25879655 DOI: 10.1186/S12985-015-0266-8 |
0.374 |
|
| 2014 |
Sharma K, Goehe R, Beckta JM, Valerie K, Gewirtz DA. Autophagy and radiosensitization in cancer. Excli Journal. 13: 178-91. PMID 26417252 DOI: 10.17877/De290R-197 |
0.389 |
|
| 2014 |
Beckta JM, Ahmad SF, Yang H, Valerie K. Revisiting p53 for cancer-specific chemo- and radiotherapy: ten years after. Cell Cycle (Georgetown, Tex.). 13: 710-3. PMID 24526114 DOI: 10.4161/Cc.28108 |
0.415 |
|
| 2014 |
Akopiants K, Mohapatra S, Menon V, Zhou T, Valerie K, Povirk LF. Tracking the processing of damaged DNA double-strand break ends by ligation-mediated PCR: increased persistence of 3'-phosphoglycolate termini in SCAN1 cells. Nucleic Acids Research. 42: 3125-37. PMID 24371269 DOI: 10.1093/Nar/Gkt1347 |
0.42 |
|
| 2014 |
Karlin J, Tokarz M, Beckta J, Farhan A, Pike K, Barlaam B, MacFaul P, Patel B, Thomason A, Tudge E, Wilson J, Lau A, Cadogan E, Durant S, Valerie K. A Novel ATM Kinase Inhibitor Effectively Radiosensitizes Glioblastoma in Mice International Journal of Radiation Oncology*Biology*Physics. 90: S35. DOI: 10.1016/J.Ijrobp.2014.05.148 |
0.35 |
|
| 2013 |
Khalil AA, Jameson MJ, Broaddus WC, Chung TD, Golding SE, Dever SM, Rosenberg E, Valerie K. Subcutaneous administration of D-luciferin is an effective alternative to intraperitoneal injection in bioluminescence imaging of xenograft tumors in nude mice. Isrn Molecular Imaging. 2013. PMID 25392739 DOI: 10.1155/2013/689279 |
0.652 |
|
| 2013 |
Menon VR, Peterson EJ, Valerie K, Farrell NP, Povirk LF. Ligand modulation of a dinuclear platinum compound leads to mechanistic differences in cell cycle progression and arrest. Biochemical Pharmacology. 86: 1708-20. PMID 24161784 DOI: 10.1016/J.Bcp.2013.10.012 |
0.377 |
|
| 2013 |
Zhang Q, Raje V, Yakovlev VA, Yacoub A, Szczepanek K, Meier J, Derecka M, Chen Q, Hu Y, Sisler J, Hamed H, Lesnefsky EJ, Valerie K, Dent P, Larner AC. Mitochondrial localized Stat3 promotes breast cancer growth via phosphorylation of serine 727. The Journal of Biological Chemistry. 288: 31280-8. PMID 24019511 DOI: 10.1074/Jbc.M113.505057 |
0.39 |
|
| 2013 |
Khalil AA, Jameson MJ, Broaddus WC, Lin PS, Dever SM, Golding SE, Rosenberg E, Valerie K, Chung TD. The Influence of Hypoxia and pH on Bioluminescence Imaging of Luciferase-Transfected Tumor Cells and Xenografts. International Journal of Molecular Imaging. 2013: 287697. PMID 23936647 DOI: 10.1155/2013/287697 |
0.685 |
|
| 2013 |
Biddlestone-Thorpe L, Sajjad M, Rosenberg E, Beckta JM, Valerie NC, Tokarz M, Adams BR, Wagner AF, Khalil A, Gilfor D, Golding SE, Deb S, Temesi DG, Lau A, O'Connor MJ, ... ... Valerie K, et al. ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 3189-200. PMID 23620409 DOI: 10.1158/1078-0432.Ccr-12-3408 |
0.752 |
|
| 2013 |
White ER, Ma Z, Hacker DE, Beckta JM, Huie MB, Williams DC, Valerie K, Hartman MC. Abstract 4539: Selection of non-phophorylated peptide inhibitors of BRCA1. Cancer Research. 73: 4539-4539. DOI: 10.1158/1538-7445.Am2013-4539 |
0.338 |
|
| 2012 |
Beckta JM, Henderson SC, Valerie K. Two- and three-dimensional live cell imaging of DNA damage response proteins. Journal of Visualized Experiments : Jove. PMID 23052275 DOI: 10.3791/4251 |
0.436 |
|
| 2012 |
Zolotarskaya OY, Wagner AF, Beckta JM, Valerie K, Wynne KJ, Yang H. Synthesis of water-soluble camptothecin-polyoxetane conjugates via click chemistry. Molecular Pharmaceutics. 9: 3403-8. PMID 23051100 DOI: 10.1021/Mp3005066 |
0.32 |
|
| 2012 |
Goehe RW, Di X, Sharma K, Bristol ML, Henderson SC, Valerie K, Rodier F, Davalos AR, Gewirtz DA. The autophagy-senescence connection in chemotherapy: must tumor cells (self) eat before they sleep? The Journal of Pharmacology and Experimental Therapeutics. 343: 763-78. PMID 22927544 DOI: 10.1124/Jpet.112.197590 |
0.368 |
|
| 2012 |
Golding SE, Rosenberg E, Adams BR, Wignarajah S, Beckta JM, O'Connor MJ, Valerie K. Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control Cell Cycle. 11: 1167-1173. PMID 22370485 DOI: 10.4161/Cc.11.6.19576 |
0.749 |
|
| 2012 |
Dever SM, White ER, Hartman MC, Valerie K. BRCA1-directed, enhanced and aberrant homologous recombination: mechanism and potential treatment strategies. Cell Cycle (Georgetown, Tex.). 11: 687-94. PMID 22306997 DOI: 10.4161/Cc.11.4.19212 |
0.344 |
|
| 2012 |
Biddlestone-Thorpe L, Muhammad S, Rosenberg E, Golding SE, Adams BR, Tokarz M, Khalil A, Gilfor D, O'Connor M, Valerie K. Abstract 1450: Targeting the ATM kinase as a novel strategy for radiosensitizing glioblastoma multiforme in mice Cancer Research. 72: 1450-1450. DOI: 10.1158/1538-7445.Am2012-1450 |
0.68 |
|
| 2011 |
Golding SE, Valerie K. MRE11 and ATM AKTivate pro-survival signaling. Cell Cycle (Georgetown, Tex.). 10: 3227. PMID 21946569 DOI: 10.4161/Cc.10.19.17048 |
0.764 |
|
| 2011 |
Hawkins AJ, Golding SE, Khalil A, Valerie K. DNA double-strand break - induced pro-survival signaling. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 101: 13-7. PMID 21726915 DOI: 10.1016/J.Radonc.2011.05.074 |
0.743 |
|
| 2011 |
Dever SM, Golding SE, Rosenberg E, Adams BR, Idowu MO, Quillin JM, Valerie N, Xu B, Povirk LF, Valerie K. Mutations in the BRCT binding site of BRCA1 result in hyper-recombination. Aging. 3: 515-32. PMID 21666281 |
0.688 |
|
| 2011 |
Khalil A, Morgan RN, Adams BR, Golding SE, Dever SM, Rosenberg E, Povirk LF, Valerie K. ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks. Cell Cycle (Georgetown, Tex.). 10: 481-91. PMID 21263216 DOI: 10.4161/Cc.10.3.14713 |
0.755 |
|
| 2011 |
Di X, Bristol ML, Valerie K, Hawkins AJ, Gewirtz DA. Abstract 2638: Association between Adriamycin-induced autophagy and senescence in breast cancer cells Cancer Research. 71: 2638-2638. DOI: 10.1158/1538-7445.Am2011-2638 |
0.372 |
|
| 2011 |
Adams B, Golding S, Biddlestone-Thorpe L, Beckta J, Saleh H, Enikopolov G, Valerie K. In Vivo and In Vitro Human Brain Tumor Models for Improving the Therapeutic Ratio of Ionizing Radiation and DNA Repair Inhibitors International Journal of Radiation Oncology*Biology*Physics. 81: S741-S742. DOI: 10.1016/J.Ijrobp.2011.06.1225 |
0.723 |
|
| 2010 |
Adams BR, Hawkins AJ, Povirk LF, Valerie K. ATM-independent, high-fidelity nonhomologous end joining predominates in human embryonic stem cells. Aging. 2: 582-96. PMID 20844317 |
0.328 |
|
| 2010 |
Adams BR, Golding SE, Rao RR, Valerie K. Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants. Plos One. 5: e10001. PMID 20368801 DOI: 10.1371/Journal.Pone.0010001 |
0.739 |
|
| 2010 |
Hawkins AJ, White DE, Golding SE, Akopiants K, Rauscher FJ, Povirk LF, Valerie K. Abstract 3923: ATM and KAP1 are required for nonhomologous end-joining in transcriptionally active chromatin Cancer Research. 70: 3923-3923. DOI: 10.1158/1538-7445.Am10-3923 |
0.753 |
|
| 2009 |
Golding SE, Rosenberg E, Valerie N, Hussaini I, Frigerio M, Cockcroft XF, Chong WY, Hummersone M, Rigoreau L, Menear KA, O'Connor MJ, Povirk LF, van Meter T, Valerie K. Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Molecular Cancer Therapeutics. 8: 2894-902. PMID 19808981 DOI: 10.1158/1535-7163.Mct-09-0519 |
0.757 |
|
| 2009 |
Zhou T, Akopiants K, Mohapatra S, Lin PS, Valerie K, Ramsden DA, Lees-Miller SP, Povirk LF. Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks. Dna Repair. 8: 901-11. PMID 19505854 DOI: 10.1016/J.Dnarep.2009.05.003 |
0.443 |
|
| 2009 |
Akopiants K, Zhou RZ, Mohapatra S, Valerie K, Lees-Miller SP, Lee KJ, Chen DJ, Revy P, de Villartay JP, Povirk LF. Requirement for XLF/Cernunnos in alignment-based gap filling by DNA polymerases lambda and mu for nonhomologous end joining in human whole-cell extracts. Nucleic Acids Research. 37: 4055-62. PMID 19420065 DOI: 10.1093/Nar/Gkp283 |
0.389 |
|
| 2009 |
Golding SE, Morgan RN, Adams BR, Hawkins AJ, Povirk LF, Valerie K. Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells. Cancer Biology & Therapy. 8: 730-8. PMID 19252415 DOI: 10.4161/Cbt.8.8.7927 |
0.75 |
|
| 2009 |
Hawkins AJ, Subler MA, Akopiants K, Wiley JL, Taylor SM, Rice AC, Windle JJ, Valerie K, Povirk LF. In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation. Dna Repair. 8: 654-63. PMID 19211312 DOI: 10.1016/J.Dnarep.2008.12.012 |
0.37 |
|
| 2008 |
Su ZZ, Lee SG, Emdad L, Lebdeva IV, Gupta P, Valerie K, Sarkar D, Fisher PB. Cloning and characterization of SARI (suppressor of AP-1, regulated by IFN). Proceedings of the National Academy of Sciences of the United States of America. 105: 20906-11. PMID 19074269 DOI: 10.1073/Pnas.0807975106 |
0.378 |
|
| 2008 |
Chan I, Lebedeva IV, Su ZZ, Sarkar D, Valerie K, Fisher PB. Progression elevated gene-3 promoter (PEG-Prom) confers cancer cell selectivity to human polynucleotide phosphorylase (hPNPase(old-35))-mediated growth suppression. Journal of Cellular Physiology. 215: 401-9. PMID 17960560 DOI: 10.1002/Jcp.21320 |
0.388 |
|
| 2007 |
Povirk LF, Zhou RZ, Ramsden DA, Lees-Miller SP, Valerie K. Phosphorylation in the serine/threonine 2609-2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts. Nucleic Acids Research. 35: 3869-78. PMID 17526517 DOI: 10.1093/Nar/Gkm339 |
0.324 |
|
| 2007 |
Valerie K, Yacoub A, Hagan MP, Curiel DT, Fisher PB, Grant S, Dent P. Radiation-induced cell signaling: inside-out and outside-in. Molecular Cancer Therapeutics. 6: 789-801. PMID 17363476 DOI: 10.1158/1535-7163.Mct-06-0596 |
0.488 |
|
| 2007 |
Golding SE, Rosenberg E, Neill S, Dent P, Povirk LF, Valerie K. Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response. Cancer Research. 67: 1046-53. PMID 17283137 DOI: 10.1158/0008-5472.Can-06-2371 |
0.756 |
|
| 2007 |
Yacoub A, Hawkins W, Hanna D, Young H, Park MA, Grant M, Roberts JD, Curiel DT, Fisher PB, Valerie K, Grant S, Hagan MP, Dent P. Human chorionic gonadotropin modulates prostate cancer cell survival after irradiation or HMG CoA reductase inhibitor treatment. Molecular Pharmacology. 71: 259-75. PMID 17050804 DOI: 10.1124/Mol.106.031153 |
0.457 |
|
| 2006 |
Sauane M, Gupta P, Lebedeva IV, Su ZZ, Sarkar D, Randolph A, Valerie K, Gopalkrishnan RV, Fisher PB. N-glycosylation of MDA-7/IL-24 is dispensable for tumor cell-specific apoptosis and "bystander" antitumor activity. Cancer Research. 66: 11869-77. PMID 17178884 DOI: 10.1158/0008-5472.Can-06-1887 |
0.337 |
|
| 2006 |
Gupta P, Walter MR, Su ZZ, Lebedeva IV, Emdad L, Randolph A, Valerie K, Sarkar D, Fisher PB. BiP/GRP78 is an intracellular target for MDA-7/IL-24 induction of cancer-specific apoptosis. Cancer Research. 66: 8182-91. PMID 16912197 DOI: 10.1158/0008-5472.Can-06-0577 |
0.306 |
|
| 2006 |
Contessa JN, Abell A, Valerie K, Lin PS, Schmidt-Ullrich RK. ErbB receptor tyrosine kinase network inhibition radiosensitizes carcinoma cells. International Journal of Radiation Oncology, Biology, Physics. 65: 851-8. PMID 16751066 DOI: 10.1016/J.Ijrobp.2006.02.025 |
0.36 |
|
| 2006 |
Lebedeva IV, Sarkar D, Su ZZ, Gopalkrishnan RV, Athar M, Randolph A, Valerie K, Dent P, Fisher PB. Molecular target-based therapy of pancreatic cancer. Cancer Research. 66: 2403-13. PMID 16489047 DOI: 10.1158/0008-5472.Can-05-3510 |
0.326 |
|
| 2006 |
Emdad L, Sarkar D, Su ZZ, Randolph A, Boukerche H, Valerie K, Fisher PB. Activation of the nuclear factor kappaB pathway by astrocyte elevated gene-1: implications for tumor progression and metastasis. Cancer Research. 66: 1509-16. PMID 16452207 DOI: 10.1158/0008-5472.Can-05-3029 |
0.338 |
|
| 2006 |
Contessa JN, Abell A, Mikkelsen RB, Valerie K, Schmidt-Ullrich RK. Compensatory ErbB3/c-Src signaling enhances carcinoma cell survival to ionizing radiation. Breast Cancer Research and Treatment. 95: 17-27. PMID 16267617 DOI: 10.1007/S10549-005-9023-9 |
0.42 |
|
| 2005 |
Boukerche H, Su ZZ, Emdad L, Baril P, Balme B, Thomas L, Randolph A, Valerie K, Sarkar D, Fisher PB. mda-9/Syntenin: a positive regulator of melanoma metastasis. Cancer Research. 65: 10901-11. PMID 16322237 DOI: 10.1158/0008-5472.Can-05-1614 |
0.419 |
|
| 2005 |
Jones KR, Gewirtz DA, Yannone SM, Zhou S, Schatz DG, Valerie K, Povirk LF. Radiosensitization of MDA-MB-231 breast tumor cells by adenovirus-mediated overexpression of a fragment of the XRCC4 protein. Molecular Cancer Therapeutics. 4: 1541-7. PMID 16227403 DOI: 10.1158/1535-7163.Mct-05-0193 |
0.473 |
|
| 2005 |
Sarkar D, Su ZZ, Vozhilla N, Park ES, Randolph A, Valerie K, Fisher PB. Targeted virus replication plus immunotherapy eradicates primary and distant pancreatic tumors in nude mice. Cancer Research. 65: 9056-63. PMID 16204080 DOI: 10.1158/0008-5472.Can-05-1261 |
0.334 |
|
| 2005 |
Sarkar D, Park ES, Emdad L, Randolph A, Valerie K, Fisher PB. Defining the domains of human polynucleotide phosphorylase (hPNPaseOLD-35) mediating cellular senescence. Molecular and Cellular Biology. 25: 7333-43. PMID 16055741 DOI: 10.1128/Mcb.25.16.7333-7343.2005 |
0.304 |
|
| 2005 |
Sturla LM, Amorino G, Alexander MS, Mikkelsen RB, Valerie K, Schmidt-Ullrichr RK. Requirement of Tyr-992 and Tyr-1173 in phosphorylation of the epidermal growth factor receptor by ionizing radiation and modulation by SHP2. The Journal of Biological Chemistry. 280: 14597-604. PMID 15708852 DOI: 10.1074/Jbc.M413287200 |
0.425 |
|
| 2005 |
Zhou T, Lee JW, Tatavarthi H, Lupski JR, Valerie K, Povirk LF. Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1). Nucleic Acids Research. 33: 289-97. PMID 15647511 DOI: 10.1093/Nar/Gki170 |
0.428 |
|
| 2005 |
Su ZZ, Sarkar D, Emdad L, Duigou GJ, Young CS, Ware J, Randolph A, Valerie K, Fisher PB. Targeting gene expression selectively in cancer cells by using the progression-elevated gene-3 promoter. Proceedings of the National Academy of Sciences of the United States of America. 102: 1059-64. PMID 15647352 DOI: 10.1073/Pnas.0409141102 |
0.348 |
|
| 2004 |
Lammering G, Hewit TH, Holmes M, Valerie K, Hawkins W, Lin PS, Mikkelsen RB, Schmidt-Ullrich RK. Inhibition of the type III epidermal growth factor receptor variant mutant receptor by dominant-negative EGFR-CD533 enhances malignant glioma cell radiosensitivity. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 6732-43. PMID 15475464 DOI: 10.1158/1078-0432.Ccr-04-0393 |
0.367 |
|
| 2004 |
Lammering G, Valerie K, Lin PS, Hewit TH, Schmidt-Ullrich RK. Radiation-induced activation of a common variant of EGFR confers enhanced radioresistance. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 72: 267-73. PMID 15450724 DOI: 10.1016/J.Radonc.2004.07.004 |
0.435 |
|
| 2004 |
Sauane M, Lebedeva IV, Su ZZ, Choo HT, Randolph A, Valerie K, Dent P, Gopalkrishnan RV, Fisher PB. Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways. Cancer Research. 64: 2988-93. PMID 15126330 DOI: 10.1158/0008-5472.Can-04-0200 |
0.341 |
|
| 2004 |
Golding SE, Rosenberg E, Khalil A, McEwen A, Holmes M, Neill S, Povirk LF, Valerie K. Double strand break repair by homologous recombination is regulated by cell cycle-independent signaling via ATM in human glioma cells. The Journal of Biological Chemistry. 279: 15402-10. PMID 14744854 DOI: 10.1074/Jbc.M314191200 |
0.745 |
|
| 2004 |
Kang DC, Gopalkrishnan RV, Lin L, Randolph A, Valerie K, Pestka S, Fisher PB. Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: a novel type I interferon-responsive apoptosis-inducing gene. Oncogene. 23: 1789-800. PMID 14676839 DOI: 10.1038/Sj.Onc.1207300 |
0.336 |
|
| 2003 |
Tong Z, Singh G, Valerie K, Rainbow AJ. Activation of the stress-activated JNK and p38 MAP kinases in human cells by Photofrin-mediated photodynamic therapy. Journal of Photochemistry and Photobiology. B, Biology. 71: 77-85. PMID 14705642 DOI: 10.1016/J.Jphotobiol.2003.08.001 |
0.401 |
|
| 2003 |
Taher MM, Lammering G, Hershey C, Valerie K. Curcumin inhibits ultraviolet light induced human immunodeficiency virus gene expression. Molecular and Cellular Biochemistry. 254: 289-97. PMID 14674708 DOI: 10.1023/A:1027393719610 |
0.385 |
|
| 2003 |
Oakley JD, Taher MM, Hershey CM, Aggarwal PC, Estwani IB, Valerie K. Triggering of apoptosis is not sufficient to induce human immunodeficiency virus gene expression. Iubmb Life. 55: 415-27. PMID 14584593 DOI: 10.1080/1521654031000146768 |
0.326 |
|
| 2003 |
Valerie K, Povirk LF. Regulation and mechanisms of mammalian double-strand break repair. Oncogene. 22: 5792-812. PMID 12947387 DOI: 10.1038/Sj.Onc.1206679 |
0.462 |
|
| 2003 |
Lammering G, Hewit TH, Valerie K, Contessa JN, Amorino GP, Dent P, Schmidt-Ullrich RK. EGFRvIII-mediated radioresistance through a strong cytoprotective response. Oncogene. 22: 5545-53. PMID 12944901 DOI: 10.1038/Sj.Onc.1206788 |
0.486 |
|
| 2003 |
Forgues M, Difilippantonio MJ, Linke SP, Ried T, Nagashima K, Feden J, Valerie K, Fukasawa K, Wang XW. Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles. Molecular and Cellular Biology. 23: 5282-92. PMID 12861014 DOI: 10.1128/Mcb.23.15.5282-5292.2003 |
0.353 |
|
| 2003 |
Amorino GP, Mikkelsen RB, Valerie K, Schmidt-Ullrich RK. Dominant-negative cAMP-responsive element-binding protein inhibits proliferating cell nuclear antigen and DNA repair, leading to increased cellular radiosensitivity. The Journal of Biological Chemistry. 278: 29394-9. PMID 12734192 DOI: 10.1074/Jbc.M304012200 |
0.504 |
|
| 2003 |
Sarkar D, Leszczyniecka M, Kang DC, Lebedeva IV, Valerie K, Dhar S, Pandita TK, Fisher PB. Down-regulation of Myc as a potential target for growth arrest induced by human polynucleotide phosphorylase (hPNPaseold-35) in human melanoma cells. The Journal of Biological Chemistry. 278: 24542-51. PMID 12721301 DOI: 10.1074/Jbc.M302421200 |
0.379 |
|
| 2003 |
Qiao L, Han SI, Fang Y, Park JS, Gupta S, Gilfor D, Amorino G, Valerie K, Sealy L, Engelhardt JF, Grant S, Hylemon PB, Dent P. Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes. Molecular and Cellular Biology. 23: 3052-66. PMID 12697808 DOI: 10.1128/Mcb.23.9.3052-3066.2003 |
0.37 |
|
| 2003 |
Su ZZ, Lebedeva IV, Sarkar D, Gopalkrishnan RV, Sauane M, Sigmon C, Yacoub A, Valerie K, Dent P, Fisher PB. Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner. Oncogene. 22: 1164-80. PMID 12606943 DOI: 10.1038/Sj.Onc.1206062 |
0.391 |
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| 2003 |
Sengupta S, Linke SP, Pedeux R, Yang Q, Farnsworth J, Garfield SH, Valerie K, Shay JW, Ellis NA, Wasylyk B, Harris CC. BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination. The Embo Journal. 22: 1210-22. PMID 12606585 DOI: 10.1093/Emboj/Cdg114 |
0.39 |
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| 2003 |
Dent P, Yacoub A, Contessa J, Caron R, Amorino G, Valerie K, Hagan MP, Grant S, Schmidt-Ullrich R. Stress and radiation-induced activation of multiple intracellular signaling pathways. Radiation Research. 159: 283-300. PMID 12600231 DOI: 10.1667/0033-7587(2003)159[0283:Sariao]2.0.Co;2 |
0.421 |
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| 2003 |
Lammering G, Hewitt T, Contessa J, Valerie K, Lin P, Mikkelsen R, Schmitt G, Schmidt-Ullrich R. 705 A naturally occurring type III variant mutant EGF receptor confers a strong cytoprotective response to ionizing radiation European Journal of Cancer Supplements. 1: S212. DOI: 10.1016/S1359-6349(03)90736-1 |
0.303 |
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| 2002 |
Leszczyniecka M, Kang DC, Sarkar D, Su ZZ, Holmes M, Valerie K, Fisher PB. Identification and cloning of human polynucleotide phosphorylase, hPNPase old-35, in the context of terminal differentiation and cellular senescence. Proceedings of the National Academy of Sciences of the United States of America. 99: 16636-41. PMID 12473748 DOI: 10.1073/Pnas.252643699 |
0.335 |
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| 2002 |
Amorino GP, Hamilton VM, Valerie K, Dent P, Lammering G, Schmidt-Ullrich RK. Epidermal growth factor receptor dependence of radiation-induced transcription factor activation in human breast carcinoma cells. Molecular Biology of the Cell. 13: 2233-44. PMID 12134064 DOI: 10.1091/Mbc.01-12-0572 |
0.426 |
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| 2002 |
Sarkar D, Su ZZ, Lebedeva IV, Sauane M, Gopalkrishnan RV, Valerie K, Dent P, Fisher PB. mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK. Proceedings of the National Academy of Sciences of the United States of America. 99: 10054-9. PMID 12114539 DOI: 10.1073/Pnas.152327199 |
0.4 |
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| 2002 |
Chouinard N, Valerie K, Rouabhia M, Huot J. UVB-mediated activation of p38 mitogen-activated protein kinase enhances resistance of normal human keratinocytes to apoptosis by stabilizing cytoplasmic p53. The Biochemical Journal. 365: 133-45. PMID 12071847 DOI: 10.1042/Bj20020072 |
0.4 |
|
| 2002 |
Contessa JN, Hampton J, Lammering G, Mikkelsen RB, Dent P, Valerie K, Schmidt-Ullrich RK. Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells. Oncogene. 21: 4032-41. PMID 12037685 DOI: 10.1038/Sj.Onc.1205500 |
0.42 |
|
| 2002 |
Rosenberg E, Hawkins W, Holmes M, Amir C, Schmidt-Ullrich RK, Lin PS, Valerie K. Radiosensitization of human glioma cells in vitro and in vivo with acyclovir and mutant HSV-TK75 expressed from adenovirus. International Journal of Radiation Oncology, Biology, Physics. 52: 831-6. PMID 11849808 DOI: 10.1016/S0360-3016(01)02754-7 |
0.367 |
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| 2002 |
Contessa J, Abell A, Lammering G, Hewit T, Valerie K, Schmidt-Ullrich R. EGRF-CD533 acts as a PAN-ERBB receptor tyrosine kinase inhibitor International Journal of Radiation Oncology*Biology*Physics. 54: 175-176. DOI: 10.1016/S0360-3016(02)03361-8 |
0.307 |
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| 2001 |
Lammering G, Lin PS, Contessa JN, Hampton JL, Valerie K, Schmidt-Ullrich RK. Adenovirus-mediated overexpression of dominant negative epidermal growth factor receptor-CD533 as a gene therapeutic approach radiosensitizes human carcinoma and malignant glioma cells. International Journal of Radiation Oncology, Biology, Physics. 51: 775-84. PMID 11697324 DOI: 10.1016/S0360-3016(01)01714-X |
0.383 |
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| 2001 |
Qiao L, Studer E, Leach K, McKinstry R, Gupta S, Decker R, Kukreja R, Valerie K, Nagarkatti P, El Deiry W, Molkentin J, Schmidt-Ullrich R, Fisher PB, Grant S, Hylemon PB, et al. Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: Inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis Molecular Biology of the Cell. 12: 2629-2645. PMID 11553704 DOI: 10.1091/Mbc.12.9.2629 |
0.408 |
|
| 2001 |
Laferrière J, Houle F, Taher MM, Valerie K, Huot J. Transendothelial Migration of Colon Carcinoma Cells Requires Expression of E-selectin by Endothelial Cells and Activation of Stress-activated Protein Kinase-2 (SAPK2/p38) in the Tumor Cells Journal of Biological Chemistry. 276: 33762-33772. PMID 11448946 DOI: 10.1074/Jbc.M008564200 |
0.384 |
|
| 2001 |
Lammering G, Hewit TH, Hawkins WT, Contessa JN, Reardon DB, Lin PS, Valerie K, Dent P, Mikkelsen RB, Schmidt-Ullrich RK. Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization. Journal of the National Cancer Institute. 93: 921-9. PMID 11416113 DOI: 10.1093/Jnci/93.12.921 |
0.405 |
|
| 2001 |
Deschesnes RG, Huot J, Valerie K, Landry J. Involvement of p38 in apoptosis-associated membrane blebbing and nuclear condensation. Molecular Biology of the Cell. 12: 1569-82. PMID 11408569 DOI: 10.1091/Mbc.12.6.1569 |
0.381 |
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| 2001 |
Dent P, Logsdon C, Nicke B, Valerie K, Farnsworth J, Schmidt-Ullrich R, Reardon DB. Recombinant adenoviral expression of dominant-negative Ras N17 blocking radiation-induced activation of mitogen-activated protein kinase pathway. Methods in Enzymology. 333: 28-37. PMID 11400343 DOI: 10.1016/S0076-6879(01)33041-0 |
0.433 |
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| 2001 |
Gewirtz DA, Di YM, Randolph JK, Jain PT, Valerie K, Bullock S, Nath N, Chellappan SP. Rb dephosphorylation and suppression of E2F activity in human breast tumor cells exposed to a pharmacological concentration of estradiol. Archives of Biochemistry and Biophysics. 388: 243-52. PMID 11368161 DOI: 10.1006/Abbi.2000.2278 |
0.385 |
|
| 2001 |
Bowers G, Reardon D, Hewitt T, Dent P, Mikkelsen RB, Valerie K, Lammering G, Amir C, Schmidt-Ullrich RK. The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells Oncogene. 20: 1388-1397. PMID 11313882 DOI: 10.1038/Sj.Onc.1204255 |
0.442 |
|
| 2001 |
Valerie K, Hawkins W, Farnsworth J, Schmidt-Ullrich R, Lin PS, Amir C, Feden J. Substantially improved in vivo radiosensitization of rat glioma with mutant HSV-TK and acyclovir. Cancer Gene Therapy. 8: 3-8. PMID 11219491 DOI: 10.1038/Sj.Cgt.7700265 |
0.34 |
|
| 2001 |
Lammering G, Hewit T, Contessa J, Hawkins W, Lin P, Valerie K, Mikkelsen R, Dent P, Schmidt-Ullrich R. EGFR and its mutant EGFRvIII as modulators of tumor cell radiosensitivity International Journal of Radiation Oncology*Biology*Physics. 51: 103. DOI: 10.1016/S0360-3016(01)02012-0 |
0.445 |
|
| 2000 |
Valerie K, Brust D, Farnsworth J, Amir C, Taher MM, Hershey C, Feden J. Improved radiosensitization of rat glioma cells with adenovirus-expressed mutant herpes simplex virus-thymidine kinase in combination with acyclovir. Cancer Gene Therapy. 7: 879-84. PMID 10880018 DOI: 10.1038/Sj.Cgt.7700185 |
0.383 |
|
| 2000 |
Brust D, Feden J, Farnsworth J, Amir C, Broaddus WC, Valerie K. Radiosensitization of rat glioma with bromodeoxycytidine and adenovirus expressing herpes simplex virus-thymidine kinase delivered by slow, rate-controlled positive pressure infusion. Cancer Gene Therapy. 7: 778-88. PMID 10830725 DOI: 10.1038/Sj.Cgt.7700168 |
0.41 |
|
| 2000 |
Taher MM, Hershey CM, Oakley JD, Valerie K. Role of the p38 and MEK-1/2/p42/44 MAP kinase pathways in the differential activation of human immunodeficiency virus gene expression by ultraviolet and ionizing radiation Photochemistry and Photobiology. 71: 455-459. PMID 10824597 DOI: 10.1562/0031-8655(2000)071<0455:Rotpam>2.0.Co;2 |
0.421 |
|
| 2000 |
Taher MM, Oakley JD, Hershey C, Valerie K. Activation of NF-κB and p38 MAP kinase is not sufficient for triggering efficient HIV gene expression in response to stress Biochemistry. 39: 1709-1715. PMID 10677219 DOI: 10.1021/Bi9921079 |
0.351 |
|
| 2000 |
Schmidt-Ullrich RK, Dent P, Grant S, Mikkelsen RB, Valerie K. Signal transduction and cellular radiation responses Radiation Research. 153: 245-257. PMID 10669545 DOI: 10.1667/0033-7587(2000)153[0245:Stacrr]2.0.Co;2 |
0.45 |
|
| 2000 |
Lammering G, Valerie K, Lin P, Mikkelsen R, Hewit T, Schmidt-Ullrich R. Radiosensitization of malignant glioma cells through overexpression of dominant-negative EGFR-CD533 International Journal of Radiation Oncology*Biology*Physics. 48: 246-247. DOI: 10.1016/S0360-3016(00)80289-8 |
0.306 |
|
| 1999 |
Schmidt-Ullrich RK, Contessa JN, Dent P, Mikkelsen RB, Valerie K, Reardon DB, Bowers G, Lin PS. Molecular mechanisms of radiation-induced accelerated repopulation. Radiation Oncology Investigations. 7: 321-30. PMID 10644055 DOI: 10.1002/(Sici)1520-6823(1999)7:6<321::Aid-Roi2>3.0.Co;2-Q |
0.3 |
|
| 1999 |
Broaddus WC, Liu Y, Steele LL, Gillies GT, Lin PS, Loudon WG, Valerie K, Schmidt-Ullrich RK, Fillmore HL. Enhanced radiosensitivity of malignant glioma cells after adenoviral p53 transduction Journal of Neurosurgery. 91: 997-1004. PMID 10584846 DOI: 10.3171/Jns.1999.91.6.0997 |
0.384 |
|
| 1999 |
Todd DG, Mikkelsen RB, Rorrer WK, Valerie K, Schmidt-Ullrich RK. Ionizing radiation stimulates existing signal transduction pathways involving the activation of epidermal growth factor receptor and erbb-3, and changes of intracellular calcium in a431 human squamous carcinoma cells Journal of Receptor and Signal Transduction Research. 19: 885-908. PMID 10533979 DOI: 10.3109/10799899909038430 |
0.393 |
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| 1999 |
Taher MM, Baumgardner T, Dent P, Valerie K. Genetic evidence that stress-activated p38 MAP kinase is necessary but not sufficient for UV activation of HIV gene expression Biochemistry. 38: 13055-13062. PMID 10529175 DOI: 10.1021/Bi9902900 |
0.324 |
|
| 1999 |
Reardon DB, Contessa JN, Mikkelsen RB, Valerie K, Amir C, Dent P, Schmidt-Ullrich RK. Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells. Oncogene. 18: 4756-66. PMID 10467423 DOI: 10.1038/Sj.Onc.1202849 |
0.434 |
|
| 1999 |
Dent P, Reardon DB, Park JS, Bowers G, Logsdon C, Valerie K, Schmidt-Ullrich R. Radiation-induced release of transforming growth factor α activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death Molecular Biology of the Cell. 10: 2493-2506. PMID 10436007 DOI: 10.1091/Mbc.10.8.2493 |
0.438 |
|
| 1999 |
Schmidt-ullrich R, Bowers G, Dent P, Reardon D, Contessa J, Valerie K. 29 ERBB receptor tyrosine kinases as determinants of cytoprotective and cytotoxic radiation responses of carcinoma cells International Journal of Radiation Oncology*Biology*Physics. 45: 161-162. DOI: 10.1016/S0360-3016(99)90047-0 |
0.386 |
|
| 1998 |
Carter S, Auer KL, Reardon DB, Birrer M, Fisher PB, Valerie K, Schmidt-Ullrich R, Mikkelsen R, Dent P. Inhibition of the mitogen activated protein (MAP) kinase cascade potentiates cell killing by low dose ionizing radiation in A431 human squamous carcinoma cells Oncogene. 16: 2787-2796. PMID 9652746 DOI: 10.1038/Sj.Onc.1201802 |
0.447 |
|
| 1997 |
Schmidt-Ullrich RK, Mikkelsen RB, Dent P, Todd DG, Valerie K, Kavanagh BD, Contessa JN, Rorrer WK, Chen PB. Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation. Oncogene. 15: 1191-7. PMID 9294612 DOI: 10.1038/Sj.Onc.1201275 |
0.431 |
|
| 1996 |
Valerie K, Laster WS, Cheng L, Kirkham JC, Reavey P, Kuemmere NB. Signal transduction and HIV transcriptional activation after exposure to ultraviolet light and other DNA-damaging agents. Photochemistry and Photobiology. 64: 280-5. PMID 8760569 DOI: 10.1111/J.1751-1097.1996.Tb02459.X |
0.322 |
|
| 1996 |
Valerie K, Laster WS, Kirkham JC, Kuemmerle NB. Ionizing radiation activates nuclear factor kappa B but fails to produce an increase in human immunodeficiency virus gene expression in stably transfected human cells. Biochemistry. 34: 15768-76. PMID 7495808 DOI: 10.1021/Bi00048A022 |
0.348 |
|
| 1996 |
Valerie K, Singhal A, Kirkham JC, Laster WS, Rosenberg M. Activation of human immunodeficiency virus gene expression by ultraviolet light in stably transfected human cells does not require the enhancer element. Biochemistry. 34: 15760-7. PMID 7495807 DOI: 10.1021/Bi00048A021 |
0.352 |
|
| 1996 |
Schmidt-Ullrich R, Mikkelsen R, Valerie K, Todd D, Kavanagh B, Contessa J, Rorrer K, Chen P. 134 Molecular mechanisms of radiation-induced cell proliferation in human carcinoma cells International Journal of Radiation Oncology*Biology*Physics. 36: 225. DOI: 10.1016/S0360-3016(97)85475-2 |
0.367 |
|
| 1995 |
Valerie K, Singhal A. Host-cell reactivation of reporter genes introduced into cells by adenovirus as a convenient way to measure cellular DNA repair Mutation Research-Dna Repair. 336: 91-100. PMID 7528900 DOI: 10.1016/0921-8777(94)00046-9 |
0.387 |
|
| 1995 |
Valerie K. Replacing tryptophan-128 of T4 endonuclease V with a serine residue results in decreased enzymatic activity in vitro and in vivo. Nucleic Acids Research. 23: 3764-70. PMID 7479008 DOI: 10.1093/Nar/23.18.3764 |
0.382 |
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| 1995 |
Schmidt-Ullrich R, Valerie K, Mikkelsen R, Todd D, Walters J, Saady M. 1023 Epidermal growth factor-receptor and radiation-induced signal transduction in human mammary and squamous carcinoma cells International Journal of Radiation Oncology*Biology*Physics. 32: 234. DOI: 10.1016/0360-3016(95)97848-U |
0.363 |
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| 1993 |
Zmudzka BZ, Strickland AG, Miller SA, Valerie K, Dall'Acqua F, Beer JZ. Activation of the human immunodeficiency virus promoter by UVA radiation in combination with psoralens or angelicins. Photochemistry and Photobiology. 58: 226-32. PMID 8415914 DOI: 10.1111/J.1751-1097.1993.Tb09553.X |
0.313 |
|
| 1989 |
Henderson EE, Valerie K, Green AP, de Riel JK. Host cell reactivation of CAT-expression vectors as a method to assay for cloned DNA-repair genes Mutation Research/Reviews in Genetic Toxicology. 220: 151-160. PMID 2927423 DOI: 10.1016/0165-1110(89)90021-3 |
0.432 |
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| 1988 |
Bockrath R, Hodes MZ, Mosbaugh P, Valerie K, Riel JKd. UV mutagenesis in E. coli with excision repair initiated by uvrABC or denV gene products. Mutation Research\/Dna Repair Reports. 193: 87-96. PMID 3279310 DOI: 10.1016/0167-8817(88)90039-9 |
0.354 |
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| 1988 |
Valerie K, Delers A, Bruck C, Thiriart C, Rosenberg H, Debouck C, Rosenberg M. Activation of human immunodeficiency virus type 1 by DNA damage in human cells. Nature. 333: 78-81. PMID 3129661 DOI: 10.1038/333078A0 |
0.337 |
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