Wen Xue, Ph.D. - Publications

Affiliations: 
2009 Stony Brook University, Stony Brook, NY, United States 
Area:
Cell Biology, Molecular Biology, Genetics

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Rodríguez TC, Kwan S, Smith JL, Dadafarin S, Wu CH, Sontheimer EJ, Xue W. Multi-omics characterization of mouse hepatoblastoma identifies novel YAP1 target genes. Hepatology (Baltimore, Md.). PMID 35932276 DOI: 10.1002/hep.32713  0.307
2020 Jiang T, Sánchez-Rivera FJ, Soto-Feliciano YM, Yang Q, Song CQ, Bhuatkar A, Haynes CM, Hemann MT, Xue W. Targeting de novo purine synthesis pathway via ADSL depletion impairs liver cancer growth by perturbing mitochondrial function. Hepatology (Baltimore, Md.). PMID 33336367 DOI: 10.1002/hep.31685  0.694
2020 Smith JL, Rodríguez TC, Mou H, Kwan SY, Pratt H, Zhang XO, Cao Y, Liang S, Ozata DM, Yu T, Yin Q, Hazeltine M, Weng Z, Sontheimer EJ, Xue W. YAP1 withdrawal in hepatoblastoma drives therapeutic differentiation of tumor cells to functional hepatocyte-like cells. Hepatology (Baltimore, Md.). PMID 32452550 DOI: 10.1002/Hep.31389  0.363
2020 Jiang T, Henderson JM, Coote K, Cheng Y, Valley HC, Zhang XO, Wang Q, Rhym LH, Cao Y, Newby GA, Bihler H, Mense M, Weng Z, Anderson DG, McCaffrey AP, ... ... Xue W, et al. Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope. Nature Communications. 11: 1979. PMID 32332735 DOI: 10.1038/S41467-020-15892-8  0.333
2020 Wu SS, Li QC, Yin CQ, Xue W, Song CQ. Advances in CRISPR/Cas-based Gene Therapy in Human Genetic Diseases. Theranostics. 10: 4374-4382. PMID 32292501 DOI: 10.7150/Thno.43360  0.306
2019 Song CQ, Jiang T, Richter M, Rhym LH, Koblan LW, Zafra MP, Schatoff EM, Doman JL, Cao Y, Dow LE, Zhu LJ, Anderson DG, Liu DR, Yin H, Xue W. Adenine base editing in an adult mouse model of tyrosinaemia. Nature Biomedical Engineering. PMID 31740768 DOI: 10.1038/S41551-019-0357-8  0.345
2019 Lee J, Mou H, Ibraheim R, Liang SQ, Liu P, Xue W, Sontheimer EJ. Tissue-restricted Genome Editing Specified by MicroRNA-repressible Anti-CRISPR Proteins. Rna (New York, N.Y.). PMID 31439808 DOI: 10.1261/Rna.071704.119  0.344
2019 Kwan SY, Sheel A, Song CQ, Zhang XO, Jiang T, Dang H, Cao Y, Ozata DM, Mou H, Yin H, Weng Z, Wang XW, Xue W. Depletion of TRRAP induces p53-independent senescence in liver cancer by downregulating mitotic genes. Hepatology (Baltimore, Md.). PMID 31188495 DOI: 10.1002/Hep.30807  0.432
2019 Mou H, Ozata DM, Smith JL, Sheel A, Kwan SY, Hough S, Kucukural A, Kennedy Z, Cao Y, Xue W. CRISPR-SONIC: targeted somatic oncogene knock-in enables rapid in vivo cancer modeling. Genome Medicine. 11: 21. PMID 30987660 DOI: 10.1186/S13073-019-0627-9  0.475
2019 Wang W, Yang J, Edin ML, Wang Y, Luo Y, Wan D, Yang H, Song CQ, Xue W, Sanidad KZ, Song M, Bisbee HA, Bradbury JA, Nan G, Zhang J, et al. Targeted metabolomics identifies the cytochrome P450 monooxygenase eicosanoid pathway as a novel therapeutic target of colon tumorigenesis. Cancer Research. PMID 30803995 DOI: 10.1158/0008-5472.Can-18-3221  0.417
2019 Yin H, Xue W, Anderson DG. CRISPR-Cas: a tool for cancer research and therapeutics. Nature Reviews. Clinical Oncology. PMID 30664678 DOI: 10.1038/S41571-019-0166-8  0.378
2019 Smith JL, Mou H, Zhang X, Ozata D, Xue W. Modeling and identifying therapeutic targets in Hepatoblastoma. Journal of Clinical Oncology. 37: e21518-e21518. DOI: 10.1200/Jco.2019.37.15_Suppl.E21518  0.358
2019 Sheel A, Kwan S, Xue W. Integrating CRISPR screening with tumor genomic analyses to identify therapeutic targets in hepatocellular carcinomas (HCC) independent of P53. Journal of Clinical Oncology. 37. DOI: 10.1200/Jco.2019.37.15_Suppl.E14659  0.366
2018 Edraki A, Mir A, Ibraheim R, Gainetdinov I, Yoon Y, Song CQ, Cao Y, Gallant J, Xue W, Rivera-Pérez JA, Sontheimer EJ. A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for In Vivo Genome Editing. Molecular Cell. PMID 30581144 DOI: 10.1016/J.Molcel.2018.12.003  0.357
2018 Moon SH, Huang CH, Houlihan SL, Regunath K, Freed-Pastor WA, Morris JP, Tschaharganeh DF, Kastenhuber ER, Barsotti AM, Culp-Hill R, Xue W, Ho YJ, Baslan T, Li X, Mayle A, et al. p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression. Cell. PMID 30580964 DOI: 10.1016/J.Cell.2018.11.011  0.552
2018 Ibraheim R, Song CQ, Mir A, Amrani N, Xue W, Sontheimer EJ. All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo. Genome Biology. 19: 137. PMID 30231914 DOI: 10.1186/S13059-018-1515-0  0.33
2018 Wang D, Li J, Song CQ, Tran K, Mou H, Wu PH, Tai PWL, Mendonca CA, Ren L, Wang BY, Su Q, Gessler DJ, Zamore PD, Xue W, Gao G. Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice. Nature Biotechnology. PMID 30102296 DOI: 10.1038/Nbt.4219  0.328
2018 Song CQ, Wang D, Jiang T, O'Connor K, Tang Q, Cai L, Li X, Weng Z, Yin H, Gao G, Mueller C, Flotte TR, Xue W. In vivo genome editing partially restores alpha1-antitrypsin in a murine model of AAT deficiency. Human Gene Therapy. PMID 29597895 DOI: 10.1089/Hum.2017.225  0.411
2018 Song CQ, Xue W. CRISPR-Cas-related technologies in basic and translational liver research. Nature Reviews. Gastroenterology & Hepatology. PMID 29443117 DOI: 10.1038/Nrgastro.2018.11  0.325
2018 Yin H, Song CQ, Suresh S, Kwan SY, Wu Q, Walsh S, Ding J, Bogorad RL, Zhu LJ, Wolfe SA, Koteliansky V, Xue W, Langer R, Anderson DG. Partial DNA-guided Cas9 enables genome editing with reduced off-target activity. Nature Chemical Biology. PMID 29377001 DOI: 10.1038/Nchembio.2559  0.336
2018 Mou H, Smith J, Peng L, Yin H, Moore J, Zhang X, Song C, Sheel A, Wu Q, Ozata D, Li Y, Anderson D, Emerson C, Moore M, Weng Z, ... Xue W, et al. Abstract 3374: CRISPR/Cas9 mediated genome editing induces exon skipping by alternative splicing or exon deletion Cancer Research. 78: 3374-3374. DOI: 10.1158/1538-7445.Am2018-3374  0.387
2017 Yin H, Song CQ, Suresh S, Wu Q, Walsh S, Rhym LH, Mintzer E, Bolukbasi MF, Zhu LJ, Kauffman K, Mou H, Oberholzer A, Ding J, Kwan SY, Bogorad RL, ... ... Xue W, et al. Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing. Nature Biotechnology. PMID 29131148 DOI: 10.1038/Nbt.4005  0.35
2017 Dang H, Takai A, Forgues M, Pomyen Y, Mou H, Xue W, Ray D, Ha KCH, Morris QD, Hughes TR, Wang XW. Oncogenic Activation of the RNA Binding Protein NELFE and MYC Signaling in Hepatocellular Carcinoma. Cancer Cell. 32: 101-114.e8. PMID 28697339 DOI: 10.1016/J.Ccell.2017.06.002  0.366
2017 Mou H, Smith JL, Peng L, Yin H, Moore J, Zhang XO, Song CQ, Sheel A, Wu Q, Ozata DM, Li Y, Anderson DG, Emerson CP, Sontheimer EJ, Moore MJ, ... ... Xue W, et al. CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion. Genome Biology. 18: 108. PMID 28615073 DOI: 10.1186/S13059-017-1237-8  0.349
2017 Tammela T, Sanchez-Rivera FJ, Cetinbas NM, Wu K, Joshi NS, Helenius K, Park Y, Azimi R, Kerper NR, Wesselhoeft RA, Gu X, Schmidt L, Cornwall-Brady M, Yilmaz ÖH, Xue W, et al. A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma. Nature. PMID 28489818 DOI: 10.1038/Nature22334  0.726
2017 Mou H, Moore J, Malonia SK, Li Y, Ozata DM, Hough S, Song CQ, Smith JL, Fischer A, Weng Z, Green MR, Xue W. Genetic disruption of oncogenic Kras sensitizes lung cancer cells to Fas receptor-mediated apoptosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28320962 DOI: 10.1073/Pnas.1620861114  0.438
2017 Mou H, Moore J, Malonia S, Li Y, Ozata D, Hough S, Song C, Smith J, Yin H, Fisher A, Anderson D, Weng S, Green M, Xue W. Abstract 1028: Genetic disruption of Kras sensitizes lung cancer cells to Fas-mediated apoptosis Cancer Research. 77: 1028-1028. DOI: 10.1158/1538-7445.Am2017-1028  0.381
2016 Song CQ, Li Y, Mou H, Moore J, Park A, Pomyen Y, Hough S, Kennedy Z, Fischer A, Yin H, Anderson DG, Conte D, Zender L, Wang XW, Thorgeirsson S, ... ... Xue W, et al. Genome-wide CRISPR Screen Identifies Regulators of MAPK as Suppressors of Liver Tumors in Mice. Gastroenterology. PMID 27956228 DOI: 10.1053/J.Gastro.2016.12.002  0.387
2016 Sheel A, Xue W. Genomic Amplifications Cause False Positives in CRISPR Screens. Cancer Discovery. 6: 824-6. PMID 27485003 DOI: 10.1158/2159-8290.Cd-16-0665  0.371
2016 Tschaharganeh DF, Xue W, Calvisi DF, Evert M, Michurina TV, Dow LE, Banito A, Katz SF, Kastenhuber ER, Weissmueller S, Huang CH, Lechel A, Andersen JB, Capper D, Zender L, et al. p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer. Cell. 165: 1546-1547. PMID 27259155 DOI: 10.1016/j.cell.2016.05.058  0.506
2016 Akama-Garren EH, Joshi NS, Tammela T, Chang GP, Wagner BL, Lee DY, Rideout Iii WM, Papagiannakopoulos T, Xue W, Jacks T. A Modular Assembly Platform for Rapid Generation of DNA Constructs. Scientific Reports. 6: 16836. PMID 26887506 DOI: 10.1038/Srep16836  0.517
2016 Yin H, Song CQ, Dorkin JR, Zhu LJ, Li Y, Wu Q, Park A, Yang J, Suresh S, Bizhanova A, Gupta A, Bolukbasi MF, Walsh S, Bogorad RL, Gao G, ... ... Xue W, et al. Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo. Nature Biotechnology. PMID 26829318 DOI: 10.1038/Nbt.3471  0.388
2016 Wang D, Mou H, Tran K, Li J, Wang BY, Gessler DJ, Tai PW, Su Q, Xue W, Gao G. 733. Somatically Repairing Compound Heterozygous Recessive Mutations by Chromosomal Cut-and-Paste for In Vivo Gene Therapy Molecular Therapy. 24: S289. DOI: 10.1016/S1525-0016(16)33541-9  0.364
2015 Xue W, Wang XW. The search for precision models clinically relevant to human liver cancer. Hepatic Oncology. 2: 315-319. PMID 30191010 DOI: 10.2217/Hep.15.24  0.414
2015 Wang D, Mou H, Li S, Li Y, Hough S, Tran K, Li J, Yin H, Anderson DG, Sontheimer EJ, Weng Z, Gao G, Xue W. Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses. Human Gene Therapy. 26: 432-42. PMID 26086867 DOI: 10.1089/Hum.2015.087  0.369
2015 Mou H, Kennedy Z, Anderson DG, Yin H, Xue W. Precision cancer mouse models through genome editing with CRISPR-Cas9. Genome Medicine. 7: 53. PMID 26060510 DOI: 10.1186/S13073-015-0178-7  0.437
2015 Li Y, Park AI, Mou H, Colpan C, Bizhanova A, Akama-Garren E, Joshi N, Hendrickson EA, Feldser D, Yin H, Anderson DG, Jacks T, Weng Z, Xue W. A versatile reporter system for CRISPR-mediated chromosomal rearrangements. Genome Biology. 16: 111. PMID 26018130 DOI: 10.1186/S13059-015-0680-7  0.508
2015 Khan OF, Zaia EW, Jhunjhunwala S, Xue W, Cai W, Yun DS, Barnes CM, Dahlman JE, Dong Y, Pelet JM, Webber MJ, Tsosie JK, Jacks TE, Langer R, Anderson DG. Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature. Nano Letters. 15: 3008-16. PMID 25789998 DOI: 10.1021/Nl5048972  0.506
2015 Li J, Chanrion M, Sawey E, Wang T, Chow E, Tward A, Su Y, Xue W, Lucito R, Zender L, Lowe SW, Bishop JM, Powers S. Reciprocal interaction of Wnt and RXR-α pathways in hepatocyte development and hepatocellular carcinoma. Plos One. 10: e0118480. PMID 25738607 DOI: 10.1371/Journal.Pone.0118480  0.533
2014 Sánchez-Rivera FJ, Papagiannakopoulos T, Romero R, Tammela T, Bauer MR, Bhutkar A, Joshi NS, Subbaraj L, Bronson RT, Xue W, Jacks T. Rapid modelling of cooperating genetic events in cancer through somatic genome editing. Nature. 516: 428-31. PMID 25337879 DOI: 10.1038/Nature13906  0.74
2014 Xue W, Chen S, Yin H, Tammela T, Papagiannakopoulos T, Joshi NS, Cai W, Yang G, Bronson R, Crowley DG, Zhang F, Anderson DG, Sharp PA, Jacks T. CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature. 514: 380-4. PMID 25119044 DOI: 10.1038/Nature13589  0.559
2014 Xue W, Dahlman JE, Tammela T, Khan OF, Sood S, Dave A, Cai W, Chirino LM, Yang GR, Bronson R, Crowley DG, Sahay G, Schroeder A, Langer R, Anderson DG, et al. Small RNA combination therapy for lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 111: E3553-61. PMID 25114235 DOI: 10.1073/Pnas.1412686111  0.562
2014 Tschaharganeh DF, Xue W, Calvisi DF, Evert M, Michurina TV, Dow LE, Banito A, Katz SF, Kastenhuber ER, Weissmueller S, Huang CH, Lechel A, Andersen JB, Capper D, Zender L, et al. p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer. Cell. 158: 579-92. PMID 25083869 DOI: 10.1016/J.Cell.2014.05.051  0.593
2014 Shao DD, Xue W, Krall EB, Bhutkar A, Piccioni F, Wang X, Schinzel AC, Sood S, Rosenbluh J, Kim JW, Zwang Y, Roberts TM, Root DE, Jacks T, Hahn WC. KRAS and YAP1 converge to regulate EMT and tumor survival. Cell. 158: 171-84. PMID 24954536 DOI: 10.1016/J.Cell.2014.06.004  0.574
2014 Yin H, Xue W, Chen S, Bogorad RL, Benedetti E, Grompe M, Koteliansky V, Sharp PA, Jacks T, Anderson DG. Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype. Nature Biotechnology. 32: 551-3. PMID 24681508 DOI: 10.1038/Nbt.2884  0.549
2014 Tammela T, Kerper N, Xue W, Joshi N, Katajisto P, Jacks T. Abstract 99: Wnt signaling promotes tumor propagation in a mouse model of lung adenocarcinoma Cancer Research. 74: 99-99. DOI: 10.1158/1538-7445.Am2014-99  0.584
2014 Yin H, Xue W, Chen S, Bogorad RL, Benedetti E, Grompe M, Koteliansky V, Sharp PA, Jacks T, Anderson DG. Erratum: Corrigendum: Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype Nature Biotechnology. 32: 952-952. DOI: 10.1038/Nbt0914-952D  0.498
2012 Xue W, Kitzing T, Roessler S, Zuber J, Krasnitz A, Schultz N, Revill K, Weissmueller S, Rappaport AR, Simon J, Zhang J, Luo W, Hicks J, Zender L, Wang XW, et al. A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Proceedings of the National Academy of Sciences of the United States of America. 109: 8212-7. PMID 22566646 DOI: 10.1073/Pnas.1206062109  0.595
2011 Xue W, Meylan E, Oliver TG, Feldser DM, Winslow MM, Bronson R, Jacks T. Response and resistance to NF-κB inhibitors in mouse models of lung adenocarcinoma. Cancer Discovery. 1: 236-47. PMID 21874163 DOI: 10.1158/2159-8290.Cd-11-0073  0.563
2011 Oliver TG, Meylan E, Chang GP, Xue W, Burke JR, Humpton TJ, Hubbard D, Bhutkar A, Jacks T. Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. Molecular Cell. 43: 57-71. PMID 21726810 DOI: 10.1016/J.Molcel.2011.06.012  0.498
2011 Xue W, Meylan E, Oliver T, Jacks T. Abstract 1612: Investigating NF-κB pathway as a novel therapeutic target in preclinical lung cancer mouse models Cancer Research. 71: 1612-1612. DOI: 10.1158/1538-7445.Am2011-1612  0.597
2011 Xue W, Zender L, Miething C, Dickins RA, Hernando E, Krizhanovsky V, Cordon-Cardo C, Lowe SW. Erratum: Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas Nature. 473: 544-544. DOI: 10.1038/nature09909  0.434
2009 Liu LX, Lee NP, Chan VW, Xue W, Zender L, Zhang C, Mao M, Dai H, Wang XL, Xu MZ, Lee TK, Ng IO, Chen Y, Kung HF, Lowe SW, et al. Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma. Hepatology (Baltimore, Md.). 50: 1453-63. PMID 19676131 DOI: 10.1002/Hep.23143  0.564
2008 Krizhanovsky V, Xue W, Zender L, Yon M, Hernando E, Lowe SW. Implications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology. Cold Spring Harbor Symposia On Quantitative Biology. 73: 513-22. PMID 19150958 DOI: 10.1101/Sqb.2008.73.048  0.563
2008 Zender L, Xue W, Zuber J, Semighini CP, Krasnitz A, Ma B, Zender P, Kubicka S, Luk JM, Schirmacher P, McCombie WR, Wigler M, Hicks J, Hannon GJ, Powers S, et al. An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell. 135: 852-64. PMID 19012953 DOI: 10.1016/J.Cell.2008.09.061  0.617
2008 Gyrd-Hansen M, Darding M, Miasari M, Santoro MM, Zender L, Xue W, Tenev T, da Fonseca PCA, Zvelebil M, Bujnicki JM, Lowe S, Silke J, Meier P. IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis Nature Cell Biology. 10: 1309-1317. PMID 18931663 DOI: 10.1038/Ncb1789  0.476
2008 Burgess DJ, Doles J, Zender L, Xue W, Ma B, McCombie WR, Hannon GJ, Lowe SW, Hemann MT. Topoisomerase levels determine chemotherapy response in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 105: 9053-8. PMID 18574145 DOI: 10.1073/Pnas.0803513105  0.523
2008 Xue W, Krasnitz A, Lucito R, Sordella R, Vanaelst L, Cordon-Cardo C, Singer S, Kuehnel F, Wigler M, Powers S, Zender L, Lowe SW. DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. Genes & Development. 22: 1439-44. PMID 18519636 DOI: 10.1101/Gad.1672608  0.565
2007 He L, He X, Lim LP, De Stanchina E, Xuan Z, Liang Y, Xue W, Zender L, Magnus J, Ridzon D, Jackson AL, Linsley PS, Chen C, Lowe SW, Cleary MA, et al. A microRNA component of the p53 tumour suppressor network Nature. 447: 1130-1134. PMID 17554337 DOI: 10.1038/Nature05939  0.483
2007 Xue W, Zender L, Miething C, Dickins RA, Hernando E, Krizhanovsky V, Cordon-Cardo C, Lowe SW. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature. 445: 656-60. PMID 17251933 DOI: 10.1038/Nature05529  0.555
2006 Lakshmi B, Hall IM, Egan C, Alexander J, Leotta A, Healy J, Zender L, Spector MS, Xue W, Lowe SW, Wigler M, Lucito R. Mouse genomic representational oligonucleotide microarray analysis: detection of copy number variations in normal and tumor specimens. Proceedings of the National Academy of Sciences of the United States of America. 103: 11234-9. PMID 16844783 DOI: 10.1073/Pnas.0602984103  0.536
2006 Zender L, Spector MS, Xue W, Flemming P, Cordon-Cardo C, Silke J, Fan ST, Luk JM, Wigler M, Hannon GJ, Mu D, Lucito R, Powers S, Lowe SW. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell. 125: 1253-67. PMID 16814713 DOI: 10.1016/J.Cell.2006.05.030  0.618
2005 Zender L, Xue W, Cordón-Cardo C, Hannon GJ, Lucito R, Powers S, Flemming P, Spector MS, Lowe SW. Generation and analysis of genetically defined liver carcinomas derived from bipotential liver progenitors. Cold Spring Harbor Symposia On Quantitative Biology. 70: 251-61. PMID 16869761 DOI: 10.1101/Sqb.2005.70.059  0.587
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