Robert MacLaren - Publications

Affiliations: 
University of Oxford, Oxford, United Kingdom 

68 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Yusuf IH, MacLaren RE. Choroideremia: Toward Regulatory Approval of Retinal Gene Therapy. Cold Spring Harbor Perspectives in Medicine. PMID 37277205 DOI: 10.1101/cshperspect.a041279  0.332
2023 Martinez-Fernandez de la Camara C, Cehajic-Kapetanovic J, MacLaren RE. Emerging gene therapy products for RPGR-associated X-linked retinitis pigmentosa. Expert Opinion On Emerging Drugs. 27: 431-443. PMID 36562395 DOI: 10.1080/14728214.2022.2152003  0.305
2022 Cehajic-Kapetanovic J, Martinez-Fernandez de la Camara C, Birtel J, Rehman S, McClements ME, Charbel Issa P, Lotery AJ, MacLaren RE. Impaired glutamylation of RPGR underlies the cone-dominated phenotype associated with truncating distal ORF15 variants. Proceedings of the National Academy of Sciences of the United States of America. 119: e2208707119. PMID 36445968 DOI: 10.1073/pnas.2208707119  0.314
2022 Leroy BP, Fischer MD, Flannery JG, MacLaren RE, Dalkara D, Scholl HPN, Chung DC, Spera C, Viriato D, Banhazi J. Gene therapy for inherited retinal disease: long-term durability of effect. Ophthalmic Research. PMID 36103843 DOI: 10.1159/000526317  0.308
2022 Poli FE, Yusuf IH, Clouston P, Shanks M, Whitfield J, Charbel Issa P, MacLaren RE. MERTK missense variants in three patients with retinitis pigmentosa. Ophthalmic Genetics. 1-9. PMID 36036427 DOI: 10.1080/13816810.2022.2113541  0.315
2022 McClements ME, Staurenghi F, Visel M, Flannery JG, MacLaren RE, Cehajic-Kapetanovic J. AAV Induced Expression of Human Rod and Cone Opsin in Bipolar Cells of a Mouse Model of Retinal Degeneration. Biomed Research International. 2021: 1-8. PMID 35465048 DOI: 10.1155/2021/4014797  0.316
2022 McClements ME, Steward H, Atkin W, Goode EA, Gándara C, Chichagova V, MacLaren RE. Tropism of AAV Vectors in Photoreceptor-Like Cells of Human iPSC-Derived Retinal Organoids. Translational Vision Science & Technology. 11: 3. PMID 35377942 DOI: 10.1167/tvst.11.4.3  0.317
2022 Cehajic-Kapetanovic J, Singh MS, Zrenner E, MacLaren RE. Bioengineering strategies for restoring vision. Nature Biomedical Engineering. PMID 35102278 DOI: 10.1038/s41551-021-00836-4  0.309
2022 Yusuf IH, Garrett A, MacLaren RE, Issa PC. Retinal cadherins and the retinal cadherinopathies: Current concepts and future directions. Progress in Retinal and Eye Research. 101038. PMID 35066146 DOI: 10.1016/j.preteyeres.2021.101038  0.32
2021 Khan AH, Sutton J, Cree AJ, Khandhadia S, De Salvo G, Tobin J, Prakash P, Arora R, Amoaku W, Issa PC, MacLaren RE, Bishop PN, Peto T, Mohamed Q, Steel DH, et al. Prevalence and Phenotype Associations of Complement Factor I Mutations in Geographic Atrophy. Human Mutation. PMID 34153144 DOI: 10.1002/humu.24242  0.583
2021 Yusuf IH, McClements ME, MacLaren RE, Issa PC. Deep phenotyping of the Cdhr1 mouse validates its use in pre-clinical studies for human CDHR1-associated retinal degeneration. Experimental Eye Research. 108603. PMID 33964272 DOI: 10.1016/j.exer.2021.108603  0.634
2021 Gilhooley MJ, Hickey D, Lindner M, Palumaa T, Hughes S, Peirson SN, MacLaren RE, Hankins MW. ON-bipolar cell gene expression during retinal degeneration: Implications for optogenetic visual restoration. Experimental Eye Research. 108553. PMID 33811915 DOI: 10.1016/j.exer.2021.108553  0.302
2021 Birtel J, Gliem M, Herrmann P, Neuhaus C, Holz FG, MacLaren RE, Scholl HPN, Charbel Issa P. North Carolina macular dystrophy shows a particular drusen phenotype and atrophy progression. The British Journal of Ophthalmology. PMID 33785507 DOI: 10.1136/bjophthalmol-2021-318815  0.472
2021 Buckley TMW, Jolly JK, Josan AS, Wood LJ, Cehajic-Kapetanovic J, MacLaren RE. Clinical applications of microperimetry in RPGR-related retinitis pigmentosa: a review. Acta Ophthalmologica. PMID 33783139 DOI: 10.1111/aos.14816  0.304
2020 Downes SM, Nguyen T, Tai V, Broadgate S, Shah M, Al-Khuzaei S, MacLaren RE, Shanks M, Clouston P, Halford S. Genetic and Clinical Findings in an Ethnically Diverse Cohort with Retinitis Pigmentosa Associated with Pathogenic Variants in CERKL. Genes. 11. PMID 33322828 DOI: 10.3390/genes11121497  0.326
2020 McClements ME, Staurenghi F, MacLaren RE, Cehajic-Kapetanovic J. Optogenetic Gene Therapy for the Degenerate Retina: Recent Advances. Frontiers in Neuroscience. 14: 570909. PMID 33262683 DOI: 10.3389/fnins.2020.570909  0.34
2020 Jolly JK, Menghini M, Johal PA, Buckley TMW, Bridge H, Maclaren RE. Inner retinal thickening affects microperimetry thresholds in the presence of photoreceptor thinning in patients with retinitis pigmentosa. The British Journal of Ophthalmology. PMID 33127827 DOI: 10.1136/bjophthalmol-2020-317692  0.3
2020 Cehajic-Kapetanovic J, McClements ME, Whitfield J, Shanks M, Clouston P, MacLaren RE. Association of a Novel Intronic Variant in RPGR With Hypomorphic Phenotype of X-Linked Retinitis Pigmentosa. Jama Ophthalmology. PMID 32970112 DOI: 10.1001/jamaophthalmol.2020.3634  0.305
2020 Cehajic-Kapetanovic J, McClements ME, Whitfield J, Shanks M, Clouston P, MacLaren RE. Association of a Novel Intronic Variant in RPGR With Hypomorphic Phenotype of X-Linked Retinitis Pigmentosa. Jama Ophthalmology. PMID 32970112 DOI: 10.1001/jamaophthalmol.2020.3634  0.305
2020 Hassall MM, McClements ME, Barnard AR, Patricio MÍ, Aslam SA, Maclaren RE. Analysis of Early Cone Dysfunction in an In Vivo Model of Rod-Cone Dystrophy. International Journal of Molecular Sciences. 21. PMID 32842706 DOI: 10.3390/ijms21176055  0.304
2020 Cundy O, Broadgate S, Halford S, MacLaren RE, Shanks ME, Clouston P, Gilhooley MJ, Downes SM. "Genetic and clinical findings in an ethnically diverse retinitis pigmentosa cohort associated with pathogenic variants in EYS". Eye (London, England). PMID 32728228 DOI: 10.1038/s41433-020-1105-8  0.301
2020 McClements ME, Barnard AR, Issa PC, MacLaren RE. Assessment of AAV Dual Vector Safety in the Mouse Model of Stargardt Disease. Translational Vision Science & Technology. 9: 20. PMID 32724727 DOI: 10.1167/Tvst.9.7.20  0.581
2020 Orlans H, Barnard AR, Patricio MM, McClements ME, MacLaren RE. Effect of AAV-mediated rhodopsin gene augmentation on retinal degeneration caused by the dominant P23H rhodopsin mutation in a knock-in murine model. Human Gene Therapy. PMID 32394751 DOI: 10.1089/hum.2020.008  0.329
2020 Menghini M, Cehajic-Kapetanovic J, MacLaren RE. Monitoring progression of retinitis pigmentosa: current recommendations and recent advances. Expert Opinion On Orphan Drugs. 8: 67-78. PMID 32231889 DOI: 10.1080/21678707.2020.1735352  0.326
2020 Cehajic-Kapetanovic J, Xue K, Martinez-Fernandez de la Camara C, Nanda A, Davies A, Wood LJ, Salvetti AP, Fischer MD, Aylward JW, Barnard AR, Jolly JK, Luo E, Lujan BJ, Ong T, Girach A, ... ... MacLaren RE, et al. Initial results from a first-in-human gene therapy trial on X-linked retinitis pigmentosa caused by mutations in RPGR. Nature Medicine. PMID 32094925 DOI: 10.1038/s41591-020-0763-1  0.326
2019 Yusuf IH, Birtel J, Shanks ME, Clouston P, Downes SM, Charbel Issa P, MacLaren RE. Clinical Characterization of Retinitis Pigmentosa Associated With Variants in SNRNP200. Jama Ophthalmology. PMID 31486839 DOI: 10.1001/Jamaophthalmol.2019.3298  0.328
2019 Cehajic-Kapetanovic J, Birtel J, McClements ME, Shanks ME, Clouston P, Downes SM, Charbel Issa P, MacLaren RE. Clinical and Molecular Characterization of PROM1-Related Retinal Degeneration. Jama Network Open. 2: e195752. PMID 31199449 DOI: 10.1001/jamanetworkopen.2019.5752  0.331
2019 Horner F, Wawrzynski J, MacLaren R. Novel non-sense mutation in RP2 (c.843_844insT/p.Arg282fs) is associated with a severe phenotype of retinitis pigmentosa without evidence of primary retinal pigment epithelium involvement. Bmj Case Reports. 12. PMID 31079036 DOI: 10.1136/bcr-2018-224451  0.366
2018 Birtel J, Salvetti AP, Jolly JK, Xue K, Gliem M, Müller PL, Holz FG, MacLaren RE, Charbel Issa P. Near-Infrared Autofluorescence in Choroideremia: Anatomic and Functional Correlations. American Journal of Ophthalmology. 199: 19-27. PMID 30713139 DOI: 10.1016/J.Ajo.2018.10.021  0.344
2018 Fischer MD, Ochakovski GA, Beier B, Seitz IP, Vaheb Y, Kortuem C, Reichel FFL, Kuehlewein L, Kahle NA, Peters T, Girach A, Zrenner E, Ueffing M, MacLaren RE, Bartz-Schmidt K, et al. CHANGES IN RETINAL SENSITIVITY AFTER GENE THERAPY IN CHOROIDEREMIA. Retina (Philadelphia, Pa.). PMID 30308560 DOI: 10.1097/Iae.0000000000002360  0.303
2018 Xue K, Jolly JK, Barnard AR, Rudenko A, Salvetti AP, Patrício MI, Edwards TL, Groppe M, Orlans HO, Tolmachova T, Black GC, Webster AR, Lotery AJ, Holder GE, Downes SM, ... ... MacLaren RE, et al. Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia. Nature Medicine. 24: 1507-1512. PMID 30297895 DOI: 10.1038/s41591-018-0185-5  0.303
2018 Hariri AH, Ip MS, Girach A, Lam BL, Fischer MD, Sankila EM, Pennesi ME, Holz FG, Maclaren RE, Birch DG, Hoyng CB, MacDonald IM, Black GC, Tsang SH, Bressler NM, et al. Macular spatial distribution of preserved autofluorescence in patients with choroideremia. The British Journal of Ophthalmology. PMID 30297337 DOI: 10.1136/Bjophthalmol-2018-312620  0.367
2018 Gray JM, Orlans HO, Shanks M, Clouston P, MacLaren RE. Slowly progressive retinitis pigmentosa caused by two novel mutations in the MAK gene. Ophthalmic Genetics. 1-4. PMID 29781741 DOI: 10.1080/13816810.2018.1474369  0.312
2018 Battaglia Parodi M, Arrigo A, MacLaren RE, Aragona E, Toto L, Mastropasqua R, Manitto MP, Bandello F. VASCULAR ALTERATIONS REVEALED WITH OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN PATIENTS WITH CHOROIDEREMIA. Retina (Philadelphia, Pa.). PMID 29543633 DOI: 10.1097/IAE.0000000000002118  0.313
2018 Nanda A, Salvetti AP, Martinez-Fernandez de la Camara C, MacLaren RE. Misdiagnosis of X-linked retinitis pigmentosa in a choroideremia patient with heavily pigmented fundi. Ophthalmic Genetics. 1-4. PMID 29377744 DOI: 10.1080/13816810.2018.1430242  0.308
2017 Yusuf IH, Shanks ME, Clouston P, MacLaren RE. A splice-site variant in FLVCR1 produces retinitis pigmentosa without posterior column ataxia. Ophthalmic Genetics. 1-5. PMID 29192808 DOI: 10.1080/13816810.2017.1408848  0.341
2017 De Silva SR, Barnard AR, Hughes S, Tam SKE, Martin C, Singh MS, Barnea-Cramer AO, McClements ME, During MJ, Peirson SN, Hankins MW, MacLaren RE. Long-term restoration of visual function in end-stage retinal degeneration using subretinal human melanopsin gene therapy. Proceedings of the National Academy of Sciences of the United States of America. PMID 28973921 DOI: 10.1073/pnas.1701589114  0.335
2017 Hickey DG, Edwards TL, Barnard AR, Singh MS, de Silva SR, McClements ME, Flannery JG, Hankins MW, MacLaren RE. Tropism of engineered and evolved recombinant AAV serotypes in the rd1 mouse and ex vivo primate retina. Gene Therapy. PMID 28872643 DOI: 10.1038/gt.2017.85  0.31
2017 Bellingrath JS, Ochakovski GA, Seitz IP, Kohl S, Zrenner E, Hanig N, Prokisch H, Weber BH, Downes SM, Ramsden S, MacLaren RE, Fischer MD. High Symmetry of Visual Acuity and Visual Fields in RPGR-Linked Retinitis Pigmentosa. Investigative Ophthalmology & Visual Science. 58: 4457-4466. PMID 28863407 DOI: 10.1167/Iovs.17-22077  0.303
2017 Xue K, Groppe M, Salvetti AP, MacLaren RE. Technique of retinal gene therapy: delivery of viral vector into the subretinal space. Eye (London, England). PMID 28820183 DOI: 10.1038/eye.2017.158  0.317
2017 Salvetti AP, Patrício MI, Barnard AR, Orlans HO, Hickey DG, MacLaren RE. Impact of Vital Dyes on Cell Viability and Transduction Efficiency of AAV Vectors Used in Retinal Gene Therapy Surgery: An In Vitro and In Vivo Analysis. Translational Vision Science & Technology. 6: 4. PMID 28706756 DOI: 10.1167/tvst.6.4.4  0.31
2017 Ku CA, Hull S, Arno G, Vincent A, Carss K, Kayton R, Weeks D, Anderson GW, Geraets R, Parker C, Pearce DA, Michaelides M, MacLaren RE, Robson AG, Holder GE, et al. Detailed Clinical Phenotype and Molecular Genetic Findings in CLN3-Associated Isolated Retinal Degeneration. Jama Ophthalmology. PMID 28542676 DOI: 10.1001/Jamaophthalmol.2017.1401  0.345
2017 Hariri AH, Velaga SB, Girach A, Ip MS, Le PV, Lam BL, Fischer MD, Sankila EM, Pennesi M, Holz FG, MacLaren RE, Birch DG, Hoyng CB, MacDonald IM, Black GC, et al. Measurement and Reproducibility of Preserved Ellipsoid Zone Area and Preserved RPE Area in a Cohort of Eyes with Choroideremia. American Journal of Ophthalmology. PMID 28499705 DOI: 10.1016/J.Ajo.2017.05.002  0.369
2017 Latasiewicz M, Salvetti AP, MacLaren RE. A novel mutation in the dominantly inherited TOPORS gene supports haploinsufficiency as the mechanism of retinitis pigmentosa. Ophthalmic Genetics. 1-5. PMID 28453362 DOI: 10.1080/13816810.2017.1313994  0.318
2017 Simunovic MP, Xue K, Jolly JK, MacLaren RE. Structural and Functional Recovery Following Limited Iatrogenic Macular Detachment for Retinal Gene Therapy. Jama Ophthalmology. PMID 28152124 DOI: 10.1001/jamaophthalmol.2016.5630  0.312
2016 MacLaren RE, Bennett J, Schwartz SD. Gene Therapy and Stem Cell Transplantation in Retinal Disease: The New Frontier. Ophthalmology. 123: S98-S106. PMID 27664291 DOI: 10.1016/J.Ophtha.2016.06.041  0.32
2016 De Silva SR, Issa PC, Singh MS, Lipinski DM, Barnea-Cramer AO, Walker NJ, Barnard AR, Hankins MW, MacLaren RE. Single residue AAV capsid mutation improves transduction of photoreceptors in the Abca4(-/-) mouse and bipolar cells in the rd1 mouse and human retina ex-vivo. Gene Therapy. PMID 27416076 DOI: 10.1038/gt.2016.54  0.347
2016 Singh MS, Broadgate S, Mathur R, Holt R, Halford S, MacLaren RE. Hypotrichosis and juvenile macular dystrophy caused by CDH3 mutation: A candidate disease for retinal gene therapy. Scientific Reports. 6: 23674. PMID 27157923 DOI: 10.1038/srep23674  0.332
2016 Edwards TL, Jolly JK, Groppe M, Barnard AR, Cottriall CL, Tolmachova T, Black GC, Webster AR, Lotery AJ, Holder GE, Xue K, Downes SM, Simunovic MP, Seabra MC, MacLaren RE. Visual Acuity after Retinal Gene Therapy for Choroideremia. The New England Journal of Medicine. PMID 27120491 DOI: 10.1056/NEJMc1509501  0.327
2015 Müller PL, Gliem M, Mangold E, Bolz HJ, Finger RP, McGuinness M, Betz C, Jiang Z, Weber BH, MacLaren RE, Holz FG, Radu RA, Charbel Issa P. Monoallelic ABCA4 Mutations Appear Insufficient to Cause Retinopathy: A Quantitative Autofluorescence Study. Investigative Ophthalmology & Visual Science. 56: 8179-86. PMID 26720470 DOI: 10.1167/Iovs.15-17629  0.414
2015 Barnard AR, Groppe M, MacLaren RE. Gene therapy for choroideremia using an adeno-associated viral (AAV) vector. Cold Spring Harbor Perspectives in Medicine. 5: a017293. PMID 25359548 DOI: 10.1101/cshperspect.a017293  0.33
2014 MacLaren RE, Groppe M, Barnard AR, Cottriall CL, Tolmachova T, Seymour L, Clark KR, During MJ, Cremers FP, Black GC, Lotery AJ, Downes SM, Webster AR, Seabra MC. Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial. Lancet (London, England). 383: 1129-37. PMID 24439297 DOI: 10.1016/S0140-6736(13)62117-0  0.339
2013 Tolmachova T, Tolmachov OE, Barnard AR, de Silva SR, Lipinski DM, Walker NJ, Maclaren RE, Seabra MC. Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the retina of choroideremia mice and human cells ex vivo. Journal of Molecular Medicine (Berlin, Germany). 91: 825-37. PMID 23756766 DOI: 10.1007/s00109-013-1006-4  0.342
2013 Charbel Issa P, De Silva SR, Lipinski DM, Singh MS, Mouravlev A, You Q, Barnard AR, Hankins MW, During MJ, Maclaren RE. Assessment of tropism and effectiveness of new primate-derived hybrid recombinant AAV serotypes in the mouse and primate retina. Plos One. 8: e60361. PMID 23593201 DOI: 10.1371/Journal.Pone.0060361  0.307
2013 McClements ME, MacLaren RE. Gene therapy for retinal disease. Translational Research : the Journal of Laboratory and Clinical Medicine. 161: 241-54. PMID 23305707 DOI: 10.1016/j.trsl.2012.12.007  0.337
2013 Rojas J, Fernandez I, Pastor JC, Maclaren RE, Ramkissoon Y, Harsum S, Charteris DG, Van Meurs JC, Amarakoon S, Ruiz-Moreno JM, Rocha-Sousa A, Brion M, Carracedo A. A genetic case-control study confirms the implication of SMAD7 and TNF locus in the development of proliferative vitreoretinopathy. Investigative Ophthalmology & Visual Science. 54: 1665-78. PMID 23258148 DOI: 10.1167/Iovs.12-10931  0.332
2013 Lipinski DM, Thake M, MacLaren RE. Clinical applications of retinal gene therapy. Progress in Retinal and Eye Research. 32: 22-47. PMID 22995954 DOI: 10.1016/j.preteyeres.2012.09.001  0.314
2012 Tan MH, Mackay DS, Cowing J, Tran HV, Smith AJ, Wright GA, Dev-Borman A, Henderson RH, Moradi P, Russell-Eggitt I, MacLaren RE, Robson AG, Cheetham ME, Thompson DA, Webster AR, et al. Leber congenital amaurosis associated with AIPL1: challenges in ascribing disease causation, clinical findings, and implications for gene therapy. Plos One. 7: e32330. PMID 22412862 DOI: 10.1371/journal.pone.0032330  0.31
2010 Sohn EH, Chen FK, Rubin GS, Moore AT, Webster AR, MacLaren RE. Macular function assessed by microperimetry in patients with enhanced S-cone syndrome. Ophthalmology. 117: 1199-1206.e1. PMID 20171741 DOI: 10.1016/j.ophtha.2009.10.046  0.333
2010 MacLaren RE. An analysis of retinal gene therapy clinical trials. Current Opinion in Molecular Therapeutics. 11: 540-6. PMID 19806502  0.311
2007 Buch PK, MacLaren RE, Ali RR. Neuroprotective gene therapy for the treatment of inherited retinal degeneration. Current Gene Therapy. 7: 434-45. PMID 18045103 DOI: 10.2174/156652307782793531  0.308
2006 Buch PK, MacLaren RE, Durán Y, Balaggan KS, MacNeil A, Schlichtenbrede FC, Smith AJ, Ali RR. In contrast to AAV-mediated Cntf expression, AAV-mediated Gdnf expression enhances gene replacement therapy in rodent models of retinal degeneration. Molecular Therapy : the Journal of the American Society of Gene Therapy. 14: 700-9. PMID 16872907 DOI: 10.1016/j.ymthe.2006.05.019  0.314
2006 MacLaren RE, Buch PK, Smith AJ, Balaggan KS, MacNeil A, Taylor JS, Osborne NN, Ali RR. CNTF gene transfer protects ganglion cells in rat retinae undergoing focal injury and branch vessel occlusion. Experimental Eye Research. 83: 1118-27. PMID 16831422 DOI: 10.1016/j.exer.2006.05.019  0.596
1998 Maclaren RE, Taylor JS. Regeneration in the developing optic nerve: correlating observations in the opossum to other mammalian systems. Progress in Neurobiology. 53: 381-98. PMID 9364617 DOI: 10.1016/S0301-0082(97)00041-5  0.564
1997 MacLaren RE, Taylor JS. Chiasmatic specificity in the regenerating mammalian optic nerve. Experimental Neurology. 147: 279-86. PMID 9344553 DOI: 10.1006/Exnr.1997.6620  0.585
1996 MacLaren RE, Taylor JS. A critical period for axon regrowth through a lesion in the developing mammalian retina. The European Journal of Neuroscience. 7: 2111-8. PMID 8542068 DOI: 10.1111/J.1460-9568.1995.Tb00633.X  0.568
1995 MacLaren RE. Retinal haemorrhage in Himalayan mountaineers. Journal of the Royal Army Medical Corps. 141: 25-8. PMID 7602553 DOI: 10.1136/Jramc-141-01-05  0.371
1995 MacLaren RE. Asymptomatic retinal haemorrhage is common at altitude. Bmj (Clinical Research Ed.). 311: 812-3. PMID 7580472 DOI: 10.1136/bmj.311.7008.812c  0.3
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