John F. Engelhardt , Ph.D. - Publications

Affiliations: 
Anatomy & Cell Biology University of Iowa, Iowa City, IA 

203 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Sun X, Yi Y, Yan Z, Rosen BH, Liang B, Winter MC, Evans TIA, Rotti PG, Yang Y, Gray JS, Park SY, Zhou W, Zhang Y, Moll SR, Woody L, et al. In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis. Science Translational Medicine. 11. PMID 30918114 DOI: 10.1126/scitranslmed.aau7531  0.52
2019 Yu M, Sun X, Tyler SR, Liang B, Swatek AM, Lynch TJ, He N, Yuan F, Feng Z, Rotti PG, Choi SH, Shahin W, Liu X, Yan Z, Engelhardt JF. Highly Efficient Transgenesis in Ferrets Using CRISPR/Cas9-Mediated Homology-Independent Insertion at the ROSA26 Locus. Scientific Reports. 9: 1971. PMID 30760763 DOI: 10.1038/s41598-018-37192-4  0.8
2019 Tyler SR, Rotti PG, Sun X, Yi Y, Xie W, Winter MC, Flamme-Wiese MJ, Tucker BA, Mullins RF, Norris AW, Engelhardt JF. PyMINEr Finds Gene and Autocrine-Paracrine Networks from Human Islet scRNA-Seq. Cell Reports. 26: 1951-1964.e8. PMID 30759402 DOI: 10.1016/j.celrep.2019.01.063  0.44
2019 Norris AW, Ode KL, Merjaneh L, Sanda S, Yi Y, Sun X, Engelhardt JF, Hull RL. Survival in a bad neighborhood: pancreatic islets in cystic fibrosis. The Journal of Endocrinology. PMID 30759072 DOI: 10.1530/JOE-18-0468  0.44
2019 Sun X, Yi Y, Liang B, Yang Y, He N, Ode KL, Uc A, Wang K, Gibson-Corley KN, Engelhardt JF, Norris AW. Incretin dysfunction and hyperglycemia in cystic fibrosis: Role of acyl-ghrelin. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. PMID 30738804 DOI: 10.1016/j.jcf.2019.01.010  0.48
2018 He N, Rosen BH, Gray JS, Evans IA, Zieger M, Yan Z, Borel F, Liang B, Sun X, Moll SR, Brodsky MH, Mueller C, Engelhardt JF. Generation of Alpha-1 Antitrypsin Knockout and PI*ZZ Ferrets Using Crispr/Cas9. A Genetic Model of Emphysema. Annals of the American Thoracic Society. 15: S292-S293. PMID 30758999 DOI: 10.1513/AnnalsATS.201806-429MG  0.36
2018 Wang Z, Cheng F, Engelhardt JF, Yan Z, Qiu J. Development of a Novel Recombinant Adeno-Associated Virus Production System Using Human Bocavirus 1 Helper Genes. Molecular Therapy. Methods & Clinical Development. 11: 40-51. PMID 30397626 DOI: 10.1016/j.omtm.2018.09.005  0.36
2018 Montoro DT, Haber AL, Biton M, Vinarsky V, Lin B, Birket SE, Yuan F, Chen S, Leung HM, Villoria J, Rogel N, Burgin G, Tsankov AM, Waghray A, Slyper M, et al. A revised airway epithelial hierarchy includes CFTR-expressing ionocytes. Nature. PMID 30069044 DOI: 10.1038/s41586-018-0393-7  0.4
2018 Lynch TJ, Anderson PJ, Rotti PG, Tyler SR, Crooke AK, Choi SH, Montoro DT, Silverman CL, Shahin W, Zhao R, Jensen-Cody CW, Adamcakova-Dodd A, Evans TIA, Xie W, Zhang Y, et al. Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium. Cell Stem Cell. 22: 779. PMID 29727685 DOI: 10.1016/j.stem.2018.04.007  0.8
2018 Lynch TJ, Anderson PJ, Rotti PG, Tyler SR, Crooke AK, Choi SH, Montoro DT, Silverman CL, Shahin W, Zhao R, Jensen-Cody CW, Adamcakova-Dodd A, Evans TIA, Xie W, Zhang Y, et al. Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium. Cell Stem Cell. PMID 29656941 DOI: 10.1016/j.stem.2018.03.017  0.8
2018 Johnson MB, Sun X, Kodani A, Borges-Monroy R, Girskis KM, Ryu SC, Wang PP, Patel K, Gonzalez DM, Woo YM, Yan Z, Liang B, Smith RS, Chatterjee M, Coman D, et al. Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size. Nature. PMID 29643508 DOI: 10.1038/s41586-018-0035-0  0.36
2018 Rotti PG, Xie W, Poudel A, Yi Y, Sun X, Tyler SR, Uc A, Norris AW, Hara M, Engelhardt JF, Gibson-Corley KN. Pancreatic and Islet Remodeling in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Knockout Ferrets. The American Journal of Pathology. PMID 29366680 DOI: 10.1016/j.ajpath.2017.12.015  0.44
2018 Rosen BH, Evans TIA, Moll SR, Gray JS, Liang B, Sun X, Zhang Y, Jensen-Cody CW, Swatek AM, Zhou W, He N, Rotti PG, Tyler SR, Keiser NW, Anderson PJ, et al. Infection is Not Required for Mucoinflammatory Lung Disease in CFTR-knockout Ferrets. American Journal of Respiratory and Critical Care Medicine. PMID 29327941 DOI: 10.1164/rccm.201708-1616OC  0.52
2017 Swatek AM, Lynch TJ, Crooke AK, Anderson PJ, Tyler SR, Brooks L, Ivanovic M, Klesney-Tait JA, Eberlein M, Pena T, Meyerholz DK, Engelhardt JF, Parekh KR. Depletion of Airway Submucosal Glands and TP63+KRT5+ Basal Cells in Obliterative Bronchiolitis. American Journal of Respiratory and Critical Care Medicine. PMID 29236513 DOI: 10.1164/rccm.201707-1368OC  0.8
2017 Deng X, Zou W, Xiong M, Wang Z, Engelhardt JF, Ye SQ, Yan Z, Qiu J. Human Parvovirus Infection of Human Airway Epithelia Induces Pyroptotic Cell Death via Inhibiting Apoptosis. Journal of Virology. PMID 29021400 DOI: 10.1128/JVI.01533-17  0.36
2017 Sun X, Yi Y, Xie W, Liang B, Winter MC, He N, Liu X, Luo M, Yang Y, Ode KL, Uc A, Norris AW, Engelhardt JF. CFTR Influences Beta Cell Function and Insulin Secretion Through Non-Cell Autonomous Exocrine-Derived Factors. Endocrinology. 158: 3325-3338. PMID 28977592 DOI: 10.1210/en.2017-00187  0.6
2017 Hao Z, Zhu Y, Wang X, Rotti P, DiMarco C, Tyler S, Zhao X, Engelhardt JF, Hone JC, Lin Q. Real-Time Monitoring of Insulin Using a Graphene Field-Effect Transistor Aptameric Nanosensor. Acs Applied Materials & Interfaces. PMID 28770993 DOI: 10.1021/acsami.7b07684  0.36
2017 Guggino W, Benson J, Seagrave J, Yan Z, Engelhardt JF, Gao G, Conlon TJ, Cebotaru L. A PRECLINICAL STUDY IN RHESUS MACAQUES FOR CYSTIC FIBROSIS TO ASSESS GENE TRANSFER AND TRANSDUCTION BY AAV1 AND AAV5 WITH A DUAL-LUCIFERASE REPORTER SYSTEM. Human Gene Therapy. Clinical Development. PMID 28726496 DOI: 10.1089/humc.2017.067  0.84
2017 Pillay S, Zou W, Cheng F, Puschnik AS, Meyer NL, Ganaie SS, Deng X, Wosen JE, Davulcu O, Yan Z, Engelhardt JF, Brown KE, Chapman MS, Qiu J, Carette JE. AAV serotypes have distinctive interactions with domains of the cellular receptor AAVR. Journal of Virology. PMID 28679762 DOI: 10.1128/JVI.00391-17  0.36
2017 Yan Z, Feng Z, Sun X, Zhang Y, Zou W, Wang Z, Jensen-Cody C, Liang B, Park SY, Qiu J, Engelhardt JF. Human Bocavirus Type-1 Capsid Facilitates the Transduction of Ferret Airways by Adeno-Associated Virus Genomes. Human Gene Therapy. PMID 28490200 DOI: 10.1089/hum.2017.060  0.52
2017 Anderson PJ, Lynch TJ, Engelhardt JF. Multipotent Myoepithelial Progenitor Cells Are Born Early During Airway Submucosal Gland Development. American Journal of Respiratory Cell and Molecular Biology. PMID 28125268 DOI: 10.1165/rcmb.2016-0304OC  0.8
2017 Wang Z, Shen W, Cheng F, Deng X, Engelhardt JF, Yan Z, Qiu J. Parvovirus Expresses a Small Noncoding RNA that Plays an Essential Role in Virus Replication. Journal of Virology. PMID 28122984 DOI: 10.1128/JVI.02375-16  0.36
2016 Hackett TL, Ferrante SC, Hoptay CE, Engelhardt JF, Ingram JL, Zhang Y, Alcala SE, Shaheen F, Matz E, Pillai DK, Freishtat RJ. A Heterotopic Xenograft Model of Human Airways for Investigating Fibrosis in Asthma. American Journal of Respiratory Cell and Molecular Biology. PMID 27788019 DOI: 10.1165/rcmb.2016-0065MA  0.52
2016 Deng X, Xu P, Zou W, Shen W, Peng J, Liu K, Engelhardt JF, Yan Z, Qiu J. The DNA damage signaling is required for replication of the HBoV1 DNA in dividing HEK293 cells. Journal of Virology. PMID 27733644 DOI: 10.1128/JVI.01831-16  0.36
2016 Steines B, Dickey DD, Bergen J, Excoffon KJ, Weinstein JR, Li X, Yan Z, Alaiwa MH, Shah VS, Bouzek DC, Powers LS, Gansemer ND, Ostedgaard LS, Engelhardt JF, Stoltz DA, et al. CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes. Jci Insight. 1: e88728. PMID 27699238 DOI: 10.1172/jci.insight.88728  0.36
2016 Sun Z, Yu W, Navarro MS, Sweat M, Eliason S, Sharp T, Liu H, Seidel K, Zhang L, Moreno M, Lynch T, Holton NE, Rogers L, Neff T, Goodheart MJ, et al. Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal. Development (Cambridge, England). PMID 27660324 DOI: 10.1242/dev.138883  0.4
2016 Xu Q, Choksi S, Qu J, Jang J, Choe M, Banfi B, Engelhardt JF, Liu ZG. NADPH oxidases are essential for macrophage differentiation. The Journal of Biological Chemistry. PMID 27489105 DOI: 10.1074/jbc.M116.731216  0.32
2016 Yi Y, Norris AW, Wang K, Sun X, Uc A, Moran A, Engelhardt JF, Larson Ode K. Abnormal Glucose Tolerance in Infants and Young Children with Cystic Fibrosis. American Journal of Respiratory and Critical Care Medicine. PMID 27447840 DOI: 10.1164/rccm.201512-2518OC  0.44
2016 Lynch TJ, Anderson PJ, Xie W, Crooke AK, Liu X, Tyler SR, Luo M, Kusner DM, Zhang Y, Neff T, Burnette DC, Walters KS, Goodheart MJ, Parekh KR, Engelhardt JF. Wnt Signaling Regulates Airway Epithelial Stem Cells in Adult Murine Submucosal Glands. Stem Cells (Dayton, Ohio). PMID 27341073 DOI: 10.1002/stem.2443  0.84
2016 Shen W, Deng X, Zou W, Engelhardt JF, Yan Z, Qiu J. Analysis of the Cis and Trans Requirements for DNA Replication at the Right End Hairpin of the Human Bocavirus 1 Genome. Journal of Virology. PMID 27334591 DOI: 10.1128/JVI.00708-16  0.36
2016 Mou H, Vinarsky V, Tata PR, Brazauskas K, Choi SH, Crooke AK, Zhang B, Solomon GM, Turner B, Bihler H, Harrington J, Lapey A, Channick C, Keyes C, Freund A, et al. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. Cell Stem Cell. PMID 27320041 DOI: 10.1016/j.stem.2016.05.012  0.4
2016 Zou W, Cheng F, Shen W, Engelhardt JF, Yan Z, Qiu J. Nonstructural Protein NP1 of Human Bocavirus 1 Plays a Critical Role in the Expression of Viral Capsid Proteins. Journal of Virology. PMID 26912614 DOI: 10.1128/JVI.02964-15  0.92
2016 Yi Y, Sun X, Gibson-Corley K, Xie W, Liang B, He N, Tyler SR, Uc A, Philipson LH, Wang K, Hara M, Larson Ode K, Norris AW, Engelhardt JF. A Transient Metabolic Recovery from Early Life Glucose Intolerance in Cystic Fibrosis Ferrets Occurs During Pancreatic Remodeling. Endocrinology. en20151935. PMID 26862997 DOI: 10.1210/en.2015-1935  0.84
2016 Deng X, Yan Z, Cheng F, Engelhardt JF, Qiu J. Replication of an Autonomous Human Parvovirus in Non-dividing Human Airway Epithelium Is Facilitated through the DNA Damage and Repair Pathways. Plos Pathogens. 12: e1005399. PMID 26765330 DOI: 10.1371/journal.ppat.1005399  0.92
2015 Spencer NY, Yan Z, Cong L, Zhang Y, Engelhardt JF, Stanton RC. Definitive Localization of Intracellular Proteins: Novel Approach Using CRISPR-Cas9 Genome Editing, with Glucose 6-Phosphate Dehydrogenase as a Model. Analytical Biochemistry. PMID 26576833 DOI: 10.1016/j.ab.2015.11.002  0.92
2015 Evans TI, Joo NS, Keiser NW, Yan Z, Tyler SR, Xie W, Zhang Y, Hsiao JJ, Cho HJ, Wright ME, Wine JJ, Engelhardt JF. Glandular Proteome Identifies Antiprotease Cystatin C as a Critical Modulator of Airway Hydration and Clearance. American Journal of Respiratory Cell and Molecular Biology. PMID 26334941 DOI: 10.1165/rcmb.2015-0090OC  0.84
2015 Wisely SM, Ryder OA, Santymire RM, Engelhardt JF, Novak BJ. A Road Map for 21st Century Genetic Restoration: Gene Pool Enrichment of the Black-Footed Ferret. The Journal of Heredity. 106: 581-92. PMID 26304983 DOI: 10.1093/jhered/esv041  0.92
2015 Shen W, Deng X, Zou W, Cheng F, Engelhardt JF, Yan Z, Qiu J. Identification and Functional Analysis of Novel Non-structural Proteins of Human Bocavirus 1. Journal of Virology. PMID 26223640 DOI: 10.1128/JVI.01374-15  0.36
2015 Xie W, Fisher JT, Lynch TJ, Luo M, Evans TI, Neff TL, Zhou W, Zhang Y, Ou Y, Bunnett NW, Russo AF, Goodheart MJ, Parekh KR, Liu X, Engelhardt JF. CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice. The Journal of Clinical Investigation. 125: 2179. PMID 25932677 DOI: 10.1172/JCI82138  0.84
2015 Yan Z, Sun X, Feng Z, Li G, Fisher JT, Stewart ZA, Engelhardt JF. Optimization of Recombinant Adeno-Associated Virus-Mediated Expression for Large Transgenes, Using a Synthetic Promoter and Tandem Array Enhancers. Human Gene Therapy. 26: 334-46. PMID 25763813 DOI: 10.1089/hum.2015.001  0.84
2015 Joo NS, Evans IA, Cho HJ, Park IH, Engelhardt JF, Wine JJ. Proteomic analysis of pure human airway gland mucus reveals a large component of protective proteins. Plos One. 10: e0116756. PMID 25706550 DOI: 10.1371/journal.pone.0116756  0.84
2015 Yan Z, Stewart ZA, Sinn PL, Olsen JC, Hu J, McCray PB, Engelhardt JF. Ferret and pig models of cystic fibrosis: prospects and promise for gene therapy. Human Gene Therapy. Clinical Development. 26: 38-49. PMID 25675143 DOI: 10.1089/humc.2014.154  0.52
2015 Keiser NW, Birket SE, Evans IA, Tyler SR, Crooke AK, Sun X, Zhou W, Nellis JR, Stroebele EK, Chu KK, Tearney GJ, Stevens MJ, Harris JK, Rowe SM, Engelhardt JF. Defective innate immunity and hyperinflammation in newborn cystic fibrosis transmembrane conductance regulator-knockout ferret lungs. American Journal of Respiratory Cell and Molecular Biology. 52: 683-94. PMID 25317669 DOI: 10.1165/rcmb.2014-0250OC  0.84
2015 Uc A, Olivier AK, Griffin MA, Meyerholz DK, Yao J, Abu-El-Haija M, Buchanan KM, Vanegas Calderón OG, Abu-El-Haija M, Pezzulo AA, Reznikov LR, Hoegger MJ, Rector MV, Ostedgaard LS, Taft PJ, et al. Glycaemic regulation and insulin secretion are abnormal in cystic fibrosis pigs despite sparing of islet cell mass. Clinical Science (London, England : 1979). 128: 131-42. PMID 25142104 DOI: 10.1042/CS20140059  0.84
2014 Yan Z, Stewart ZA, Sinn PL, Olsen JC, Hu J, McCray Jr PB, Engelhardt JF. Ferret and Pig Models of Cystic Fibrosis: Prospects and Promise for Gene Therapy. Human Gene Therapy. Clinical Development. PMID 25549055 DOI: 10.1089/hum.2014.154  0.36
2014 Peng X, Alföldi J, Gori K, Eisfeld AJ, Tyler SR, Tisoncik-Go J, Brawand D, Law GL, Skunca N, Hatta M, Gasper DJ, Kelly SM, Chang J, Thomas MJ, Johnson J, et al. The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease. Nature Biotechnology. 32: 1250-5. PMID 25402615 DOI: 10.1038/nbt.3079  0.84
2014 Lynch TJ, Engelhardt JF. Progenitor cells in proximal airway epithelial development and regeneration. Journal of Cellular Biochemistry. 115: 1637-45. PMID 24818588 DOI: 10.1002/jcb.24834  0.84
2014 Sun X, Olivier AK, Yi Y, Pope CE, Hayden HS, Liang B, Sui H, Zhou W, Hager KR, Zhang Y, Liu X, Yan Z, Fisher JT, Keiser NW, Song Y, et al. Gastrointestinal pathology in juvenile and adult CFTR-knockout ferrets. The American Journal of Pathology. 184: 1309-22. PMID 24637292 DOI: 10.1016/j.ajpath.2014.01.035  0.84
2014 Sui H, Yi Y, Yao J, Liang B, Sun X, Hu S, Uc A, Nelson DJ, Ode KL, Philipson LH, Engelhardt JF, Norris AW. Quantifying insulin sensitivity and entero-insular responsiveness to hyper- and hypoglycemia in ferrets. Plos One. 9: e90519. PMID 24594704 DOI: 10.1371/journal.pone.0090519  0.84
2014 Spencer NY, Engelhardt JF. The basic biology of redoxosomes in cytokine-mediated signal transduction and implications for disease-specific therapies. Biochemistry. 53: 1551-64. PMID 24555469 DOI: 10.1021/bi401719r  0.84
2014 Xie W, Lynch TJ, Liu X, Tyler SR, Yu S, Zhou X, Luo M, Kusner DM, Sun X, Yi Y, Zhang Y, Goodheart MJ, Parekh KR, Wells JM, Xue HH, et al. Sox2 modulates Lef-1 expression during airway submucosal gland development. American Journal of Physiology. Lung Cellular and Molecular Physiology. 306: L645-60. PMID 24487391 DOI: 10.1152/ajplung.00157.2013  0.84
2014 Sun X, Olivier AK, Liang B, Yi Y, Sui H, Evans TI, Zhang Y, Zhou W, Tyler SR, Fisher JT, Keiser NW, Liu X, Yan Z, Song Y, Goeken JA, et al. Lung phenotype of juvenile and adult cystic fibrosis transmembrane conductance regulator-knockout ferrets. American Journal of Respiratory Cell and Molecular Biology. 50: 502-12. PMID 24074402 DOI: 10.1165/rcmb.2013-0261OC  0.84
2013 Yan Z, Sun X, Evans IA, Tyler SR, Song Y, Liu X, Sui H, Engelhardt JF. Postentry processing of recombinant adeno-associated virus type 1 and transduction of the ferret lung are altered by a factor in airway secretions. Human Gene Therapy. 24: 786-96. PMID 23948055 DOI: 10.1089/hum.2013.137  0.6
2013 Yan Z, Keiser NW, Song Y, Deng X, Cheng F, Qiu J, Engelhardt JF. A novel chimeric adenoassociated virus 2/human bocavirus 1 parvovirus vector efficiently transduces human airway epithelia. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 2181-94. PMID 23896725 DOI: 10.1038/mt.2013.92  0.36
2013 Keiser NW, Engelhardt JF. Gene delivery to the airway. Current Protocols in Human Genetics / Editorial Board, Jonathan L. Haines ... [Et Al.]. Unit 13.9. PMID 23853081 DOI: 10.1002/0471142905.hg1309s78  0.84
2013 Fisher JT, Tyler SR, Zhang Y, Lee BJ, Liu X, Sun X, Sui H, Liang B, Luo M, Xie W, Yi Y, Zhou W, Song Y, Keiser N, Wang K, et al. Bioelectric characterization of epithelia from neonatal CFTR knockout ferrets. American Journal of Respiratory Cell and Molecular Biology. 49: 837-44. PMID 23782101 DOI: 10.1165/rcmb.2012-0433OC  0.84
2013 Spencer NY, Zhou W, Li Q, Zhang Y, Luo M, Yan Z, Lynch TJ, Abbott D, Banfi B, Engelhardt JF. Hepatocytes produce TNF-α following hypoxia-reoxygenation and liver ischemia-reperfusion in a NADPH oxidase- and c-Src-dependent manner. American Journal of Physiology. Gastrointestinal and Liver Physiology. 305: G84-94. PMID 23639811 DOI: 10.1152/ajpgi.00430.2012  0.84
2013 Deng X, Yan Z, Luo Y, Xu J, Cheng F, Li Y, Engelhardt JF, Qiu J. In vitro modeling of human bocavirus 1 infection of polarized primary human airway epithelia. Journal of Virology. 87: 4097-102. PMID 23345515 DOI: 10.1128/JVI.03132-12  0.36
2013 Sui H, Olivier AK, Klesney-Tait JA, Brooks L, Tyler SR, Sun X, Skopec A, Kline J, Sanchez PG, Meyerholz DK, Zavazava N, Iannettoni M, Engelhardt JF, Parekh KR. Ferret lung transplant: an orthotopic model of obliterative bronchiolitis. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 13: 467-73. PMID 23205765 DOI: 10.1111/j.1600-6143.2012.04337.x  0.44
2013 Yan Z, Lei-Butters DC, Keiser NW, Engelhardt JF. Distinct transduction difference between adeno-associated virus type 1 and type 6 vectors in human polarized airway epithelia. Gene Therapy. 20: 328-37. PMID 22695783 DOI: 10.1038/gt.2012.46  0.36
2012 Nakano Y, Jahan I, Bonde G, Sun X, Hildebrand MS, Engelhardt JF, Smith RJ, Cornell RA, Fritzsch B, Bánfi B. A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. Plos Genetics. 8: e1002966. PMID 23055939 DOI: 10.1371/journal.pgen.1002966  0.84
2012 Olivier AK, Yi Y, Sun X, Sui H, Liang B, Hu S, Xie W, Fisher JT, Keiser NW, Lei D, Zhou W, Yan Z, Li G, Evans TI, Meyerholz DK, et al. Abnormal endocrine pancreas function at birth in cystic fibrosis ferrets. The Journal of Clinical Investigation. 122: 3755-68. PMID 22996690 DOI: 10.1172/JCI60610  0.84
2012 Huang Q, Deng X, Yan Z, Cheng F, Luo Y, Shen W, Lei-Butters DC, Chen AY, Li Y, Tang L, Söderlund-Venermo M, Engelhardt JF, Qiu J. Establishment of a reverse genetics system for studying human bocavirus in human airway epithelia. Plos Pathogens. 8: e1002899. PMID 22956907 DOI: 10.1371/journal.ppat.1002899  0.36
2012 Shelton DN, Fornalik H, Neff T, Park SY, Bender D, DeGeest K, Liu X, Xie W, Meyerholz DK, Engelhardt JF, Goodheart MJ. The role of LEF1 in endometrial gland formation and carcinogenesis. Plos One. 7: e40312. PMID 22792274 DOI: 10.1371/journal.pone.0040312  0.6
2012 Fisher JT, Liu X, Yan Z, Luo M, Zhang Y, Zhou W, Lee BJ, Song Y, Guo C, Wang Y, Lukacs GL, Engelhardt JF. Comparative processing and function of human and ferret cystic fibrosis transmembrane conductance regulator. The Journal of Biological Chemistry. 287: 21673-85. PMID 22570484 DOI: 10.1074/jbc.M111.336537  0.84
2012 Ramsey BW, Banks-Schlegel S, Accurso FJ, Boucher RC, Cutting GR, Engelhardt JF, Guggino WB, Karp CL, Knowles MR, Kolls JK, LiPuma JJ, Lynch S, McCray PB, Rubenstein RC, Singh PK, et al. Future directions in early cystic fibrosis lung disease research: an NHLBI workshop report. American Journal of Respiratory and Critical Care Medicine. 185: 887-92. PMID 22312017 DOI: 10.1164/rccm.201111-2068WS  0.84
2012 Kaminsky PM, Keiser NW, Yan Z, Lei-Butters DC, Engelhardt JF. Directing integrin-linked endocytosis of recombinant AAV enhances productive FAK-dependent transduction. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 972-83. PMID 22233580 DOI: 10.1038/mt.2011.295  0.84
2011 Li Q, Spencer NY, Pantazis NJ, Engelhardt JF. Alsin and SOD1(G93A) proteins regulate endosomal reactive oxygen species production by glial cells and proinflammatory pathways responsible for neurotoxicity. The Journal of Biological Chemistry. 286: 40151-62. PMID 21937428 DOI: 10.1074/jbc.M111.279711  0.84
2011 Keiser NW, Engelhardt JF. New animal models of cystic fibrosis: what are they teaching us? Current Opinion in Pulmonary Medicine. 17: 478-83. PMID 21857224 DOI: 10.1097/MCP.0b013e32834b14c9  0.36
2011 Xie W, Fisher JT, Lynch TJ, Luo M, Evans TI, Neff TL, Zhou W, Zhang Y, Ou Y, Bunnett NW, Russo AF, Goodheart MJ, Parekh KR, Liu X, Engelhardt JF. CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice. The Journal of Clinical Investigation. 121: 3144-58. PMID 21765217 DOI: 10.1172/JCI41857  0.84
2011 Li Y, Wang J, He HY, Ma LJ, Zeng J, Deng GC, Liu X, Engelhardt JF, Wang Y. Immunohistochemical demonstration of airway epithelial cell markers of guinea pig. Tissue & Cell. 43: 283-90. PMID 21705035 DOI: 10.1016/j.tice.2011.05.003  0.6
2011 Keiser NW, Yan Z, Zhang Y, Lei-Butters DC, Engelhardt JF. Unique characteristics of AAV1, 2, and 5 viral entry, intracellular trafficking, and nuclear import define transduction efficiency in HeLa cells. Human Gene Therapy. 22: 1433-44. PMID 21574868 DOI: 10.1089/hum.2011.044  0.52
2011 Fisher JT, Zhang Y, Engelhardt JF. Comparative biology of cystic fibrosis animal models. Methods in Molecular Biology (Clifton, N.J.). 742: 311-34. PMID 21547741 DOI: 10.1007/978-1-61779-120-8_19  0.84
2011 Spencer NY, Yan Z, Boudreau RL, Zhang Y, Luo M, Li Q, Tian X, Shah AM, Davisson RL, Davidson B, Banfi B, Engelhardt JF. Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4. The Journal of Biological Chemistry. 286: 8977-87. PMID 21212270 DOI: 10.1074/jbc.M110.193821  0.84
2011 Zhang Z, Liu X, Wu T, Liu J, Zhang X, Yang X, Goodheart MJ, Engelhardt JF, Wang Y. Selective suppression of cervical cancer Hela cells by 2-O-β-D-glucopyranosyl-L-ascorbic acid isolated from the fruit of Lycium barbarum L. Cell Biology and Toxicology. 27: 107-21. PMID 20717715 DOI: 10.1007/s10565-010-9174-2  0.6
2010 Liu X, Luo M, Xie W, Wells JM, Goodheart MJ, Engelhardt JF. Sox17 modulates Wnt3A/beta-catenin-mediated transcriptional activation of the Lef-1 promoter. American Journal of Physiology. Lung Cellular and Molecular Physiology. 299: L694-710. PMID 20802155 DOI: 10.1152/ajplung.00140.2010  0.84
2010 Sun X, Sui H, Fisher JT, Yan Z, Liu X, Cho HJ, Joo NS, Zhang Y, Zhou W, Yi Y, Kinyon JM, Lei-Butters DC, Griffin MA, Naumann P, Luo M, et al. Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis. The Journal of Clinical Investigation. 120: 3149-60. PMID 20739752 DOI: 10.1172/JCI43052  0.84
2010 Sisson TH, Mendez M, Choi K, Subbotina N, Courey A, Cunningham A, Dave A, Engelhardt JF, Liu X, White ES, Thannickal VJ, Moore BB, Christensen PJ, Simon RH. Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis. American Journal of Respiratory and Critical Care Medicine. 181: 254-63. PMID 19850947 DOI: 10.1164/rccm.200810-1615OC  0.84
2010 Flotte TR, Fischer AC, Goetzmann J, Mueller C, Cebotaru L, Yan Z, Wang L, Wilson JM, Guggino WB, Engelhardt JF. Dual reporter comparative indexing of rAAV pseudotyped vectors in chimpanzee airway. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 594-600. PMID 19826405 DOI: 10.1038/mt.2009.230  0.84
2009 Oakley FD, Smith RL, Engelhardt JF. Lipid rafts and caveolin-1 coordinate interleukin-1beta (IL-1beta)-dependent activation of NFkappaB by controlling endocytosis of Nox2 and IL-1beta receptor 1 from the plasma membrane. The Journal of Biological Chemistry. 284: 33255-64. PMID 19801678 DOI: 10.1074/jbc.M109.042127  0.6
2009 Xu G, Zhang Y, Jia H, Li J, Liu X, Engelhardt JF, Wang Y. Cloning and identification of microRNAs in bovine alveolar macrophages. Molecular and Cellular Biochemistry. 332: 9-16. PMID 19507003 DOI: 10.1007/s11010-009-0168-4  0.6
2009 Yan Z, Sun X, Engelhardt JF. Progress and prospects: techniques for site-directed mutagenesis in animal models. Gene Therapy. 16: 581-8. PMID 19225549 DOI: 10.1038/gt.2009.16  0.36
2009 Yan Z, Lei-Butters D, Engelhardt JF, Leno GH. Indexing TNF-alpha gene expression using a gene-targeted reporter cell line. Bmc Biology. 7: 8. PMID 19220876 DOI: 10.1186/1741-7007-7-8  0.36
2009 Carter BJ, Anklesaria P, Choi S, Engelhardt JF. Redox modifier genes and pathways in amyotrophic lateral sclerosis. Antioxidants & Redox Signaling. 11: 1569-86. PMID 19187001 DOI: 10.1089/ARS.2008.2414  0.84
2009 Li Q, Spencer NY, Oakley FD, Buettner GR, Engelhardt JF. Endosomal Nox2 facilitates redox-dependent induction of NF-kappaB by TNF-alpha. Antioxidants & Redox Signaling. 11: 1249-63. PMID 19113817 DOI: 10.1089/ARS.2008.2407  0.84
2009 Oakley FD, Abbott D, Li Q, Engelhardt JF. Signaling components of redox active endosomes: the redoxosomes. Antioxidants & Redox Signaling. 11: 1313-33. PMID 19072143 DOI: 10.1089/ARS.2008.2363  0.84
2009 Liu X, Luo M, Guo C, Yan Z, Wang Y, Lei-Butters DC, Engelhardt JF. Analysis of adeno-associated virus progenitor cell transduction in mouse lung. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 285-93. PMID 19034263 DOI: 10.1038/mt.2008.248  0.6
2009 Sun X, Li Z, Yi Y, Ding W, Chen J, Engelhardt JF, Leno GH. Chromatin configurations in the ferret germinal vesicle that reflect developmental competence for in vitro maturation. Reproduction in Domestic Animals = Zuchthygiene. 44: 320-5. PMID 18992097 DOI: 10.1111/j.1439-0531.2008.01076.x  0.44
2008 Crystal RG, Randell SH, Engelhardt JF, Voynow J, Sunday ME. Airway epithelial cells: current concepts and challenges. Proceedings of the American Thoracic Society. 5: 772-7. PMID 18757316 DOI: 10.1513/pats.200805-041HR  0.84
2008 Liu X, Engelhardt JF. The glandular stem/progenitor cell niche in airway development and repair. Proceedings of the American Thoracic Society. 5: 682-8. PMID 18684717 DOI: 10.1513/pats.200801-003AW  0.6
2008 Sun X, Li Z, Yi Y, Chen J, Leno GH, Engelhardt JF. Efficient term development of vitrified ferret embryos using a novel pipette chamber technique. Biology of Reproduction. 79: 832-40. PMID 18633142 DOI: 10.1095/biolreprod.107.067371  0.44
2008 Hsu MY, Rovinsky SA, Lai CY, Qasem S, Liu X, How J, Engelhardt JF, Murphy GF. Aggressive melanoma cells escape from BMP7-mediated autocrine growth inhibition through coordinated Noggin upregulation. Laboratory Investigation; a Journal of Technical Methods and Pathology. 88: 842-55. PMID 18560367 DOI: 10.1038/labinvest.2008.55  0.6
2008 Rogers CS, Abraham WM, Brogden KA, Engelhardt JF, Fisher JT, McCray PB, McLennan G, Meyerholz DK, Namati E, Ostedgaard LS, Prather RS, Sabater JR, Stoltz DA, Zabner J, Welsh MJ. The porcine lung as a potential model for cystic fibrosis. American Journal of Physiology. Lung Cellular and Molecular Physiology. 295: L240-63. PMID 18487356 DOI: 10.1152/ajplung.90203.2008  0.84
2008 Li Q, Zhang Y, Marden JJ, Banfi B, Engelhardt JF. Endosomal NADPH oxidase regulates c-Src activation following hypoxia/reoxygenation injury. The Biochemical Journal. 411: 531-41. PMID 18397177 DOI: 10.1042/BJ20071534  0.84
2008 Mumbengegwi DR, Li Q, Li C, Bear CE, Engelhardt JF. Evidence for a superoxide permeability pathway in endosomal membranes. Molecular and Cellular Biology. 28: 3700-12. PMID 18378695 DOI: 10.1128/MCB.02038-07  0.84
2008 Sun X, Yan Z, Yi Y, Li Z, Lei D, Rogers CS, Chen J, Zhang Y, Welsh MJ, Leno GH, Engelhardt JF. Adeno-associated virus-targeted disruption of the CFTR gene in cloned ferrets. The Journal of Clinical Investigation. 118: 1578-83. PMID 18324338 DOI: 10.1172/JCI34599  0.84
2008 Rogers CS, Hao Y, Rokhlina T, Samuel M, Stoltz DA, Li Y, Petroff E, Vermeer DW, Kabel AC, Yan Z, Spate L, Wax D, Murphy CN, Rieke A, Whitworth K, et al. Production of CFTR-null and CFTR-DeltaF508 heterozygous pigs by adeno-associated virus-mediated gene targeting and somatic cell nuclear transfer. The Journal of Clinical Investigation. 118: 1571-7. PMID 18324337 DOI: 10.1172/JCI34773  0.84
2008 Peterson JR, Infanger DW, Braga VA, Zhang Y, Sharma RV, Engelhardt JF, Davisson RL. Longitudinal noninvasive monitoring of transcription factor activation in cardiovascular regulatory nuclei using bioluminescence imaging. Physiological Genomics. 33: 292-9. PMID 18230667 DOI: 10.1152/physiolgenomics.00296.2007  0.84
2008 Harraz MM, Marden JJ, Zhou W, Zhang Y, Williams A, Sharov VS, Nelson K, Luo M, Paulson H, Schöneich C, Engelhardt JF. SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model. The Journal of Clinical Investigation. 118: 659-70. PMID 18219391 DOI: 10.1172/JCI34060  0.84
2008 Marden JJ, Zhang Y, Oakley FD, Zhou W, Luo M, Jia HP, McCray PB, Yaniv M, Weitzman JB, Engelhardt JF. JunD protects the liver from ischemia/reperfusion injury by dampening AP-1 transcriptional activation. The Journal of Biological Chemistry. 283: 6687-95. PMID 18182393 DOI: 10.1074/jbc.M705606200  0.84
2007 Harraz MM, Park A, Abbott D, Zhou W, Zhang Y, Engelhardt JF. MKK6 phosphorylation regulates production of superoxide by enhancing Rac GTPase activity. Antioxidants & Redox Signaling. 9: 1803-13. PMID 17854274 DOI: 10.1089/ars.2007.1579  0.84
2007 Marden JJ, Harraz MM, Williams AJ, Nelson K, Luo M, Paulson H, Engelhardt JF. Redox modifier genes in amyotrophic lateral sclerosis in mice. The Journal of Clinical Investigation. 117: 2913-9. PMID 17853944 DOI: 10.1172/JCI31265  0.84
2007 Amen M, Liu X, Vadlamudi U, Elizondo G, Diamond E, Engelhardt JF, Amendt BA. PITX2 and beta-catenin interactions regulate Lef-1 isoform expression. Molecular and Cellular Biology. 27: 7560-73. PMID 17785445 DOI: 10.1128/MCB.00315-07  0.84
2007 Liu X, Luo M, Guo C, Yan Z, Wang Y, Engelhardt JF. Comparative biology of rAAV transduction in ferret, pig and human airway epithelia. Gene Therapy. 14: 1543-8. PMID 17728794 DOI: 10.1038/sj.gt.3303014  0.6
2007 Liu X, Luo M, Trygg C, Yan Z, Lei-Butters DC, Smith CI, Fischer AC, Munson K, Guggino WB, Bunnell BA, Engelhardt JF. Biological Differences in rAAV Transduction of Airway Epithelia in Humans and in Old World Non-human Primates. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 2114-23. PMID 17667945 DOI: 10.1038/sj.mt.6300277  0.84
2007 Fox LE, Green D, Yan Z, Engelhardt JF, Wu CF. Screen for dominant behavioral mutations caused by genomic insertion of P-element transposons in Drosophila: an examination of the integration of viral vector sequences. Journal of Neurogenetics. 21: 31-43. PMID 17464796 DOI: 10.1080/01677060701209235  0.84
2007 Driskell RR, Goodheart M, Neff T, Liu X, Luo M, Moothart C, Sigmund CD, Hosokawa R, Chai Y, Engelhardt JF. Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis. Developmental Biology. 305: 90-102. PMID 17335794 DOI: 10.1016/j.ydbio.2007.01.038  0.84
2007 Yan Z, Lei-Butters DC, Zhang Y, Zak R, Engelhardt JF. Hybrid adeno-associated virus bearing nonhomologous inverted terminal repeats enhances dual-vector reconstruction of minigenes in vivo. Human Gene Therapy. 18: 81-7. PMID 17181493 DOI: 10.1089/hum.2006.128  0.52
2007 Liu X, Luo M, Zhang L, Ding W, Yan Z, Engelhardt JF. Bioelectric properties of chloride channels in human, pig, ferret, and mouse airway epithelia. American Journal of Respiratory Cell and Molecular Biology. 36: 313-23. PMID 17008635 DOI: 10.1165/rcmb.2006-0286OC  0.6
2007 Dajani R, Sanlioglu S, Zhang Y, Li Q, Monick MM, Lazartigues E, Eggleston T, Davisson RL, Hunninghake GW, Engelhardt JF. Pleiotropic functions of TNF-alpha determine distinct IKKbeta-dependent hepatocellular fates in response to LPS. American Journal of Physiology. Gastrointestinal and Liver Physiology. 292: G242-52. PMID 16935850 DOI: 10.1152/ajpgi.00043.2006  0.84
2006 Liu X, Driskell RR, Engelhardt JF. Stem cells in the lung. Methods in Enzymology. 419: 285-321. PMID 17141060 DOI: 10.1016/S0076-6879(06)19012-6  0.84
2006 Engelhardt JF. AAV hits the genomic bull's-eye. Nature Biotechnology. 24: 949-50. PMID 16900138 DOI: 10.1038/nbt0806-949  0.84
2006 Yan Z, Lei-Butters DC, Liu X, Zhang Y, Zhang L, Luo M, Zak R, Engelhardt JF. Unique biologic properties of recombinant AAV1 transduction in polarized human airway epithelia. The Journal of Biological Chemistry. 281: 29684-92. PMID 16899463 DOI: 10.1074/jbc.M604099200  0.6
2006 Hingtgen SD, Tian X, Yang J, Dunlay SM, Peek AS, Wu Y, Sharma RV, Engelhardt JF, Davisson RL. Nox2-containing NADPH oxidase and Akt activation play a key role in angiotensin II-induced cardiomyocyte hypertrophy. Physiological Genomics. 26: 180-91. PMID 16670255 DOI: 10.1152/physiolgenomics.00029.2005  0.84
2006 Li Z, Sun X, Chen J, Liu X, Wisely SM, Zhou Q, Renard JP, Leno GH, Engelhardt JF. Cloned ferrets produced by somatic cell nuclear transfer. Developmental Biology. 293: 439-48. PMID 16584722 DOI: 10.1016/j.ydbio.2006.02.016  0.6
2006 Li Q, Harraz MM, Zhou W, Zhang LN, Ding W, Zhang Y, Eggleston T, Yeaman C, Banfi B, Engelhardt JF. Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes. Molecular and Cellular Biology. 26: 140-54. PMID 16354686 DOI: 10.1128/MCB.26.1.140-154.2006  0.84
2006 Li Q, Engelhardt JF. Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase. The Journal of Biological Chemistry. 281: 1495-505. PMID 16286467 DOI: 10.1074/jbc.M511153200  0.4
2006 Liu X, Yan Z, Luo M, Engelhardt JF. Species-specific differences in mouse and human airway epithelial biology of recombinant adeno-associated virus transduction. American Journal of Respiratory Cell and Molecular Biology. 34: 56-64. PMID 16195538 DOI: 10.1165/rcmb.2005-0189OC  0.6
2005 Lai Y, Yue Y, Liu M, Ghosh A, Engelhardt JF, Chamberlain JS, Duan D. Efficient in vivo gene expression by trans-splicing adeno-associated viral vectors. Nature Biotechnology. 23: 1435-9. PMID 16244658 DOI: 10.1038/nbt1153  0.84
2005 Liu X, Luo M, Zhang LN, Yan Z, Zak R, Ding W, Mansfield SG, Mitchell LG, Engelhardt JF. Spliceosome-mediated RNA trans-splicing with recombinant adeno-associated virus partially restores cystic fibrosis transmembrane conductance regulator function to polarized human cystic fibrosis airway epithelial cells. Human Gene Therapy. 16: 1116-23. PMID 16149910 DOI: 10.1089/hum.2005.16.1116  0.6
2005 Ding W, Zhang L, Yan Z, Engelhardt JF. Intracellular trafficking of adeno-associated viral vectors. Gene Therapy. 12: 873-80. PMID 15829993 DOI: 10.1038/sj.gt.3302527  0.36
2005 Dajani R, Zhang Y, Taft PJ, Travis SM, Starner TD, Olsen A, Zabner J, Welsh MJ, Engelhardt JF. Lysozyme secretion by submucosal glands protects the airway from bacterial infection. American Journal of Respiratory Cell and Molecular Biology. 32: 548-52. PMID 15746432 DOI: 10.1165/rcmb.2005-0059OC  0.84
2005 Vadlamudi U, Espinoza HM, Ganga M, Martin DM, Liu X, Engelhardt JF, Amendt BA. PITX2, beta-catenin and LEF-1 interact to synergistically regulate the LEF-1 promoter. Journal of Cell Science. 118: 1129-37. PMID 15728254 DOI: 10.1242/jcs.01706  0.84
2005 Yan Z, Zak R, Zhang Y, Engelhardt JF. Inverted terminal repeat sequences are important for intermolecular recombination and circularization of adeno-associated virus genomes. Journal of Virology. 79: 364-79. PMID 15596830 DOI: 10.1128/JVI.79.1.364-379.2005  0.52
2005 Panopoulos A, Harraz M, Engelhardt JF, Zandi E. Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation. The Journal of Biological Chemistry. 280: 2912-23. PMID 15550384 DOI: 10.1074/jbc.M409524200  0.84
2004 Zhang LN, Karp P, Gerard CJ, Pastor E, Laux D, Munson K, Yan Z, Liu X, Godwin S, Thomas CP, Zabner J, Shi H, Caldwell CW, Peluso R, Carter B, et al. Dual therapeutic utility of proteasome modulating agents for pharmaco-gene therapy of the cystic fibrosis airway. Molecular Therapy : the Journal of the American Society of Gene Therapy. 10: 990-1002. PMID 15564131 DOI: 10.1016/j.ymthe.2004.08.009  0.84
2004 Liu X, Driskell RR, Engelhardt JF. Airway glandular development and stem cells. Current Topics in Developmental Biology. 64: 33-56. PMID 15563943 DOI: 10.1016/S0070-2153(04)64003-8  0.84
2004 Zimmerman MC, Dunlay RP, Lazartigues E, Zhang Y, Sharma RV, Engelhardt JF, Davisson RL. Requirement for Rac1-dependent NADPH oxidase in the cardiovascular and dipsogenic actions of angiotensin II in the brain. Circulation Research. 95: 532-9. PMID 15271858 DOI: 10.1161/01.RES.0000139957.22530.b9  0.84
2004 Liu X, Driskell RR, Luo M, Abbott D, Filali M, Cheng N, Sigmund CD, Engelhardt JF. Characterization of Lef-1 promoter segments that facilitate inductive developmental expression in skin. The Journal of Investigative Dermatology. 123: 264-74. PMID 15245424 DOI: 10.1111/j.0022-202X.2004.23201.x  0.84
2004 Driskell RR, Liu X, Luo M, Filali M, Zhou W, Abbott D, Cheng N, Moothart C, Sigmund CD, Engelhardt JF. Wnt-responsive element controls Lef-1 promoter expression during submucosal gland morphogenesis. American Journal of Physiology. Lung Cellular and Molecular Physiology. 287: L752-63. PMID 15194563 DOI: 10.1152/ajplung.00026.2004  0.84
2004 Sanlioglu AD, Karacay B, Benson PK, Engelhardt JF, Sanlioglu S. Novel approaches to augment adeno-associated virus type-2 endocytosis and transduction. Virus Research. 104: 51-9. PMID 15177892 DOI: 10.1016/j.virusres.2004.03.002  0.84
2004 Liu X, Yan Z, Luo M, Zak R, Li Z, Driskell RR, Huang Y, Tran N, Engelhardt JF. Targeted correction of single-base-pair mutations with adeno-associated virus vectors under nonselective conditions. Journal of Virology. 78: 4165-75. PMID 15047832 DOI: 10.1128/JVI.78.8.4165-4175.2004  0.84
2004 Fan C, Li Q, Zhang Y, Liu X, Luo M, Abbott D, Zhou W, Engelhardt JF. IkappaBalpha and IkappaBbeta possess injury context-specific functions that uniquely influence hepatic NF-kappaB induction and inflammation. The Journal of Clinical Investigation. 113: 746-55. PMID 14991073 DOI: 10.1172/JCI17337  0.6
2004 Yan Z, Zak R, Zhang Y, Ding W, Godwin S, Munson K, Peluso R, Engelhardt JF. Distinct classes of proteasome-modulating agents cooperatively augment recombinant adeno-associated virus type 2 and type 5-mediated transduction from the apical surfaces of human airway epithelia. Journal of Virology. 78: 2863-74. PMID 14990705 DOI: 10.1128/JVI.78.6.2863-2874.2004  0.52
2004 Driskell RR, Engelhardt JF. Stem Cells in the Adult Lung Handbook of Stem Cells. 2: 547-554. DOI: 10.1016/B978-012436643-5/50138-3  0.92
2003 Ding W, Yan Z, Zak R, Saavedra M, Rodman DM, Engelhardt JF. Second-strand genome conversion of adeno-associated virus type 2 (AAV-2) and AAV-5 is not rate limiting following apical infection of polarized human airway epithelia. Journal of Virology. 77: 7361-6. PMID 12805434 DOI: 10.1128/JVI.77.13.7361-7366.2003  0.36
2003 Qiao L, Han SI, Fang Y, Park JS, Gupta S, Gilfor D, Amorino G, Valerie K, Sealy L, Engelhardt JF, Grant S, Hylemon PB, Dent P. Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes. Molecular and Cellular Biology. 23: 3052-66. PMID 12697808 DOI: 10.1128/MCB.23.9.3052-3066.2003  0.84
2003 Yang J, Marden JJ, Fan C, Sanlioglu S, Weiss RM, Ritchie TC, Davisson RL, Engelhardt JF. Genetic redox preconditioning differentially modulates AP-1 and NF kappa B responses following cardiac ischemia/reperfusion injury and protects against necrosis and apoptosis. Molecular Therapy : the Journal of the American Society of Gene Therapy. 7: 341-53. PMID 12668130 DOI: 10.1016/S1525-0016(02)00061-8  0.84
2003 Xiong S, She H, Takeuchi H, Han B, Engelhardt JF, Barton CH, Zandi E, Giulivi C, Tsukamoto H. Signaling role of intracellular iron in NF-kappaB activation. The Journal of Biological Chemistry. 278: 17646-54. PMID 12637578 DOI: 10.1074/jbc.M210905200  0.84
2003 Li Z, Rezaei Sabet M, Zhou Q, Liu X, Ding W, Zhang Y, Renard JP, Engelhardt JF. Developmental capacity of ferret embryos by nuclear transfer using G0/G1-phase fetal fibroblasts. Biology of Reproduction. 68: 2297-303. PMID 12606336 DOI: 10.1095/biolreprod.102.012369  0.6
2003 Tran ND, Liu X, Yan Z, Abbote D, Jiang Q, Kmiec EB, Sigmund CD, Engelhardt JF. Efficiency of chimeraplast gene targeting by direct nuclear injection using a GFP recovery assay. Molecular Therapy : the Journal of the American Society of Gene Therapy. 7: 248-53. PMID 12597913 DOI: 10.1016/S1525-0016(02)00039-4  0.6
2003 Duan D, Yue Y, Yan Z, Engelhardt JF. Trans-splicing vectors expand the packaging limits of adeno-associated virus for gene therapy applications. Methods in Molecular Medicine. 76: 287-307. PMID 12526170 DOI: 10.1385/1-59259-304-6:287  0.36
2003 Fan C, Li Q, Ross D, Engelhardt JF. Tyrosine phosphorylation of I kappa B alpha activates NF kappa B through a redox-regulated and c-Src-dependent mechanism following hypoxia/reoxygenation. The Journal of Biological Chemistry. 278: 2072-80. PMID 12429743 DOI: 10.1074/jbc.M206718200  0.4
2002 Doerschug K, Sanlioglu S, Flaherty DM, Wilson RL, Yarovinsky T, Monick MM, Engelhardt JF, Hunninghake GW. First-generation adenovirus vectors shorten survival time in a murine model of sepsis. Journal of Immunology (Baltimore, Md. : 1950). 169: 6539-45. PMID 12444165 DOI: 10.4049/jimmunol.169.11.6539  0.84
2002 Engelhardt JF. The lung as a metabolic factory for gene therapy. The Journal of Clinical Investigation. 110: 429-32. PMID 12189234 DOI: 10.1172/JCI16443  0.84
2002 Yang GS, Schmidt M, Yan Z, Lindbloom JD, Harding TC, Donahue BA, Engelhardt JF, Kotin R, Davidson BL. Virus-mediated transduction of murine retina with adeno-associated virus: effects of viral capsid and genome size. Journal of Virology. 76: 7651-60. PMID 12097579 DOI: 10.1128/JVI.76.15.7651-7660.2002  0.84
2002 Yang J, Ritchie TC, Engelhardt JF. Model system for developing gene therapy approaches for myocardial ischemia-reperfusion injury. Methods in Enzymology. 353: 321-36. PMID 12078506 DOI: 10.1016/S0076-6879(02)53058-5  0.84
2002 Filali M, Cheng N, Abbott D, Leontiev V, Engelhardt JF. Wnt-3A/beta-catenin signaling induces transcription from the LEF-1 promoter. The Journal of Biological Chemistry. 277: 33398-410. PMID 12052822 DOI: 10.1074/jbc.M107977200  0.48
2002 Yang JQ, Buettner GR, Domann FE, Li Q, Engelhardt JF, Weydert CD, Oberley LW. v-Ha-ras mitogenic signaling through superoxide and derived reactive oxygen species. Molecular Carcinogenesis. 33: 206-18. PMID 11933074 DOI: 10.1002/mc.10037  0.84
2002 Filali M, Zhang Y, Ritchie TC, Engelhardt JF. Xenograft model of the CF airway. Methods in Molecular Medicine. 70: 537-50. PMID 11917549 DOI: 10.1385/1-59259-187-6:537  0.84
2002 Yan Z, Ritchie TC, Duan D, Engelhardt JF. Recombinant AAV-mediated gene delivery using dual vector heterodimerization. Methods in Enzymology. 346: 334-57. PMID 11883078 DOI: 10.1016/S0076-6879(02)46065-X  0.84
2002 Yan Z, Zak R, Luxton GW, Ritchie TC, Bantel-Schaal U, Engelhardt JF. Ubiquitination of both adeno-associated virus type 2 and 5 capsid proteins affects the transduction efficiency of recombinant vectors. Journal of Virology. 76: 2043-53. PMID 11836382 DOI: 10.1128/jvi.76.5.2043-2053.2002  0.84
2002 Liu X, Jiang Q, Mansfield SG, Puttaraju M, Zhang Y, Zhou W, Cohn JA, Garcia-Blanco MA, Mitchell LG, Engelhardt JF. Partial correction of endogenous DeltaF508 CFTR in human cystic fibrosis airway epithelia by spliceosome-mediated RNA trans-splicing. Nature Biotechnology. 20: 47-52. PMID 11753361 DOI: 10.1038/nbt0102-47  0.84
2001 Duan D, Zhang Y, Engelhardt JF. Gene delivery to the airway. Current Protocols in Human Genetics / Editorial Board, Jonathan L. Haines ... [Et Al.]. Unit 13.9. PMID 18428257 DOI: 10.1002/0471142905.hg1309s23  0.52
2001 Sanlioglu S, Monick MM, Luleci G, Hunninghake GW, Engelhardt JF. Rate limiting steps of AAV transduction and implications for human gene therapy. Current Gene Therapy. 1: 137-47. PMID 12108951 DOI: 10.2174/1566523013348788  0.84
2001 Li Q, Sanlioglu S, Li S, Ritchie T, Oberley L, Engelhardt JF. GPx-1 gene delivery modulates NFkappaB activation following diverse environmental injuries through a specific subunit of the IKK complex. Antioxidants & Redox Signaling. 3: 415-32. PMID 11491654 DOI: 10.1089/15230860152409068  0.84
2001 Duan D, Yan Z, Yue Y, Ding W, Engelhardt JF. Enhancement of muscle gene delivery with pseudotyped adeno-associated virus type 5 correlates with myoblast differentiation. Journal of Virology. 75: 7662-71. PMID 11462038 DOI: 10.1128/JVI.75.16.7662-7671.2001  0.36
2001 Engelhardt JF. Stem cell niches in the mouse airway American Journal of Respiratory Cell and Molecular Biology. 24: 649-652. PMID 11415927 DOI: 10.1165/ajrcmb.24.6.f206  0.84
2001 Sanlioglu S, Williams CM, Samavati L, Butler NS, Wang G, McCray PB, Ritchie TC, Hunninghake GW, Zandi E, Engelhardt JF. Lipopolysaccharide induces Rac1-dependent reactive oxygen species formation and coordinates tumor necrosis factor-alpha secretion through IKK regulation of NF-kappa B. The Journal of Biological Chemistry. 276: 30188-98. PMID 11402028 DOI: 10.1074/jbc.M102061200  0.84
2001 Ritchie TC, Zhou W, McKinstry E, Hosch M, Zhang Y, Nathke I, Engelhardt JF. Developmental expression of catenins and associated proteins during submucosal gland morphogenesis in the airway Experimental Lung Research. 27: 121-141. PMID 11258801 DOI: 10.1080/019021401750069375  0.84
2001 Wang X, Zhang Y, Amberson A, Engelhardt JF. New models of the tracheal airway define the glandular contribution to airway surface fluid and electrolyte composition. American Journal of Respiratory Cell and Molecular Biology. 24: 195-202. PMID 11159054 DOI: 10.1165/ajrcmb.24.2.3918  0.44
2000 Sanlioglu S, Benson PK, Yang J, Atkinson EM, Reynolds T, Engelhardt JF. Endocytosis and nuclear trafficking of adeno-associated virus type 2 are controlled by rac1 and phosphatidylinositol-3 kinase activation. Journal of Virology. 74: 9184-96. PMID 10982365 DOI: 10.1128/JVI.74.19.9184-9196.2000  0.84
2000 Lam EW, Hammad HM, Zwacka R, Darby CJ, Baumgardner KR, Davidson BL, Oberley TD, Engelhardt JF, Oberley LW. Immunolocalization and adenoviral vector-mediated manganese superoxide dismutase gene transfer to experimental oral tumors. Journal of Dental Research. 79: 1410-7. PMID 10890721 DOI: 10.1177/00220345000790061001  0.84
2000 Duan D, Yue Y, Yan Z, Engelhardt JF. A new dual-vector approach to enhance recombinant adeno-associated virus-mediated gene expression through intermolecular cis activation. Nature Medicine. 6: 595-8. PMID 10802719 DOI: 10.1038/75080  0.36
2000 Sanlioglu S, Benson P, Engelhardt JF. Loss of ATM function enhances recombinant adeno-associated virus transduction and integration through pathways similar to UV irradiation. Virology. 268: 68-78. PMID 10683328 DOI: 10.1006/viro.1999.0137  0.84
2000 Naren AP, Di A, Cormet-Boyaka E, Boyaka PN, McGhee JR, Zhou W, Akagawa K, Fujiwara T, Thome U, Engelhardt JF, Nelson DJ, Kirk KL. Syntaxin 1A is expressed in airway epithelial cells, where it modulates CFTR Cl(-) currents. The Journal of Clinical Investigation. 105: 377-86. PMID 10675364 DOI: 10.1172/JCI8631  0.84
2000 Walters RW, Duan D, Engelhardt JF, Welsh MJ. Incorporation of adeno-associated virus in a calcium phosphate coprecipitate improves gene transfer to airway epithelia in vitro and in vivo. Journal of Virology. 74: 535-40. PMID 10590145 DOI: 10.1128/JVI.74.1.535-540.2000  0.84
1999 Engelhardt JF. Redox-Mediated Gene Therapies for Environmental Injury: Approaches and Concepts Antioxidants and Redox Signaling. 1: 5-27. PMID 11225732 DOI: 10.1089/ars.1999.1.1-5  0.84
1999 Duan D, Yan Z, Yue Y, Engelhardt JF. Structural analysis of adeno-associated virus transduction circular intermediates. Virology. 261: 8-14. PMID 10484751 DOI: 10.1006/viro.1999.9821  0.36
1999 Sanlioglu S, Duan D, Engelhardt JF. Two independent molecular pathways for recombinant adeno-associated virus genome conversion occur after UV-C and E4orf6 augmentation of transduction. Human Gene Therapy. 10: 591-602. PMID 10094202 DOI: 10.1089/10430349950018661  0.84
1999 Epperly MW, Bray JA, Krager S, Berry LM, Gooding W, Engelhardt JF, Zwacka R, Travis EL, Greenberger JS. Intratracheal injection of adenovirus containing the human MnSOD transgene protects athymic nude mice from irradiation-induced organizing alveolitis International Journal of Radiation Oncology Biology Physics. 43: 169-181. PMID 9989524 DOI: 10.1016/S0360-3016(98)00355-1  0.84
1999 Zhang Y, Engelhardt JF. Airway surface fluid volume and Cl content in cystic fibrosis and normal bronchial xenografts American Journal of Physiology - Cell Physiology. 276. PMID 9950775 DOI: 10.1152/ajpcell.1999.276.2.C469  0.84
1999 Duan D, Li Q, Kao AW, Yue Y, Pessin JE, Engelhardt JF. Dynamin Is Required for Recombinant Adeno-Associated Virus Type 2 Infection Journal of Virology. 73: 10371-10376. DOI: 10.1128/jvi.73.12.10371-10376.1999  0.4
1999 Duan D, Sharma P, Dudus L, Zhang Y, Sanlioglu S, Yan Z, Yue Y, Ye Y, Lester R, Yang J, Fisher KJ, Engelhardt JF. Formation of Adeno-Associated Virus Circular Genomes Is Differentially Regulated by Adenovirus E4 ORF6 and E2a Gene Expression Journal of Virology. 73: 161-169. DOI: 10.1128/jvi.73.1.161-169.1999  0.52
1998 Duan D, Yue Y, Yan Z, Mccray PB, Engelhardt JF. Polarity influences the efficiency of recombinant adenoassociated virus infection in differentiated airway epithelia Human Gene Therapy. 9: 2761-2776. PMID 9874274 DOI: 10.1089/hum.1998.9.18-2761  0.84
1998 Jiang Q, Mak D, Devidas S, Schwiebert EM, Bragin A, Zhang Y, Skach WR, Guggino WB, Foskett JK, Engelhardt JF. Cystic fibrosis transmembrane conductance regulator-associated ATP release is controlled by a chloride sensor. The Journal of Cell Biology. 143: 645-57. PMID 9813087 DOI: 10.1083/jcb.143.3.645  0.84
1998 Jiang Q, Engelhardt JF. Cellular heterogeneity of CFTR expression and function in the lung: Implications for gene therapy of cystic fibrosis European Journal of Human Genetics. 6: 12-31. PMID 9781011 DOI: 10.1038/sj.ejhg.5200158  0.84
1998 Sharma P, Dudus L, Nielsen PA, Clausen H, Yankaskas JR, Hollingsworth MA, Engelhardt JF. MUC5B and MUC7 are differentially expressed in mucous and serous cells of submucosal glands in human bronchial airways American Journal of Respiratory Cell and Molecular Biology. 19: 30-37. PMID 9651178 DOI: 10.1165/ajrcmb.19.1.3054  0.84
1997 Duan D, Fisher KJ, Burda JF, Engelhardt JF. Structural and functional heterogeneity of integrated recombinant AAV genomes. Virus Research. 48: 41-56. PMID 9140193 DOI: 10.1016/S0168-1702(96)01425-6  0.84
1996 Sehgal A, Presente A, Engelhardt JF. Developmental Expression Patterns of CFTR in Ferret Tracheal Surface Airway and Submucosal Gland Epithelia American Journal of Respiratory Cell and Molecular Biology. 15: 122-131. PMID 8679216 DOI: 10.1165/ajrcmb.15.1.8679216  0.84
1995 Pilewski JM, Engelhardt JF, Bavaria JE, Kaiser LR, Wilson JM, Albelda SM. Adenovirus-mediated gene transfer to human bronchial submucosal glands using xenografts. The American Journal of Physiology. 268: L657-65. PMID 7733306  0.84
1995 Goldman MJ, Litzky LA, Engelhardt JF, Wilson JM. Transfer of the CFTR gene to the lung of nonhuman primates with E1-deleted, E2a-defective recombinant adenoviruses: a preclinical toxicology study. Human Gene Therapy. 6: 839-51. PMID 7578403 DOI: 10.1089/hum.1995.6.7-839  0.84
1995 Knowles MR, Hohneker KW, Zhou Z, Olsen JC, Noah TL, Hu PC, Leigh MW, Engelhardt JF, Edwards LJ, Jones KR. A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis. The New England Journal of Medicine. 333: 823-31. PMID 7544439 DOI: 10.1056/NEJM199509283331302  0.84
1994 Grossman M, Raper SE, Kozarsky K, Stein EA, Engelhardt JF, Muller D, Lupien PJ, Wilson JM. Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia. Nature Genetics. 6: 335-41. PMID 8054972 DOI: 10.1038/ng0494-335  0.84
1994 Engelhardt JF, Ye X, Doranz B, Wilson JM. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proceedings of the National Academy of Sciences of the United States of America. 91: 6196-200. PMID 8016137  0.84
1994 Engelhardt JF, Litzky L, Wilson JM. Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a. Human Gene Therapy. 5: 1217-29. PMID 7849095 DOI: 10.1089/hum.1994.5.10-1217  0.84
1994 Grubb BR, Pickles RJ, Ye H, Yankaskas JR, Vick RN, Engelhardt JF, Wilson JM, Johnson LG, Boucher RC. Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans. Nature. 371: 802-6. PMID 7523956 DOI: 10.1038/371802a0  0.84
1994 Yang Y, Nunes FA, Berencsi K, Gönczöl E, Engelhardt JF, Wilson JM. Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis. Nature Genetics. 7: 362-9. PMID 7522742 DOI: 10.1038/ng0794-362  0.84
1994 Engelhardt JF, Smith SS, Allen E, Yankaskas JR, Dawson DC, Wilson JM. Coupled secretion of chloride and mucus in skin of Xenopus laevis: possible role for CFTR. The American Journal of Physiology. 267: C491-500. PMID 7521128  0.84
1994 Boucher RC, Knowles MR, Johnson LG, Olsen JC, Pickles R, Wilson JM, Engelhardt J, Yang Y, Grossman M. Gene therapy for cystic fibrosis using E1-deleted adenovirus: a phase I trial in the nasal cavity. The University of North Carolina at Chapel Hill. Human Gene Therapy. 5: 615-39. PMID 7519885 DOI: 10.1089/hum.1994.5.5-615  0.84
1994 Wilson JM, Engelhardt JF, Grossman M, Simon RH, Yang Y. Gene therapy of cystic fibrosis lung disease using E1 deleted adenoviruses: a phase I trial. Human Gene Therapy. 5: 501-19. PMID 7519452 DOI: 10.1089/hum.1994.5.4-501  0.84
1994 Yang Y, Engelhardt JF, Wilson JM. Ultrastructural localization of variant forms of cystic fibrosis transmembrane conductance regulator in human bronchial epithelial of xenografts. American Journal of Respiratory Cell and Molecular Biology. 11: 7-15. PMID 7517144 DOI: 10.1165/ajrcmb.11.1.7517144  0.84
1994 Engelhardt JF, Zepeda M, Cohn JA, Yankaskas JR, Wilson JM. Expression of the cystic fibrosis gene in adult human lung. The Journal of Clinical Investigation. 93: 737-49. PMID 7509347 DOI: 10.1172/JCI117028  0.84
1993 Yang Y, Devor DC, Engelhardt JF, Ernst SA, Strong TV, Collins FS, Cohn JA, Frizzell RA, Wilson JM. Molecular basis of defective anion transport in L cells expressing recombinant forms of CFTR. Human Molecular Genetics. 2: 1253-61. PMID 7691345 DOI: 10.1093/hmg/2.8.1253  0.84
1993 Engelhardt JF, Yang Y, Stratford-Perricaudet LD, Allen ED, Kozarsky K, Perricaudet M, Yankaskas JR, Wilson JM. Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1-deleted adenoviruses. Nature Genetics. 4: 27-34. PMID 7685651 DOI: 10.1038/ng0593-27  0.84
1993 Yang Y, Raper SE, Cohn JA, Engelhardt JF, Wilson JM. An approach for treating the hepatobiliary disease of cystic fibrosis by somatic gene transfer. Proceedings of the National Academy of Sciences of the United States of America. 90: 4601-5. PMID 7685107  0.84
1993 Simon RH, Engelhardt JF, Yang Y, Zepeda M, Weber-Pendleton S, Grossman M, Wilson JM. Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: toxicity study. Human Gene Therapy. 4: 771-80. PMID 7514446 DOI: 10.1089/hum.1993.4.6-771  0.84
1993 Engelhardt JF, Simon RH, Yang Y, Zepeda M, Weber-Pendleton S, Doranz B, Grossman M, Wilson JM. Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: biological efficacy study. Human Gene Therapy. 4: 759-69. PMID 7514445 DOI: 10.1089/hum.1993.4.6-759  0.84
1992 Engelhardt JF, Wilson JM. Retroviral gene transfer into rat tracheal grafts. Chest. 101: 16S. PMID 1541187  0.84
1992 Engelhardt JF, Wilson JM. Gene therapy of cystic fibrosis lung disease. The Journal of Pharmacy and Pharmacology. 44: 165-7. PMID 1348278  0.84
1992 Engelhardt JF, Yankaskas JR, Ernst SA, Yang Y, Marino CR, Boucher RC, Cohn JA, Wilson JM. Submucosal glands are the predominant site of CFTR expression in the human bronchus. Nature Genetics. 2: 240-8. PMID 1285365 DOI: 10.1038/ng1192-240  0.84
1992 Engelhardt JF, Yankaskas JR, Wilson JM. In vivo retroviral gene transfer into human bronchial epithelia of xenografts. The Journal of Clinical Investigation. 90: 2598-607. PMID 1281842 DOI: 10.1172/JCI116155  0.84
1991 Engelhardt JF, Allen ED, Wilson JM. Reconstitution of tracheal grafts with a genetically modified epithelium. Proceedings of the National Academy of Sciences of the United States of America. 88: 11192-6. PMID 1763032  0.84
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