| Year |
Citation |
Score |
| 2015 |
Hölscher C, Sonntag F, Henrich K, Chen Q, Beneke J, Matula P, Rohr K, Kaderali L, Beil N, Erfle H, Kleinschmidt JA, Müller M. The SUMOylation Pathway Restricts Gene Transduction by Adeno-Associated Viruses. Plos Pathogens. 11: e1005281. PMID 26625259 DOI: 10.1371/journal.ppat.1005281 |
1 |
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| 2015 |
Trepel M, Körbelin J, Spies E, Heckmann MB, Hunger A, Fehse B, Katus HA, Kleinschmidt JA, Müller OJ, Michelfelder S. Treatment of multifocal breast cancer by systemic delivery of dual-targeted adeno-associated viral vectors. Gene Therapy. PMID 26034897 DOI: 10.1038/gt.2015.52 |
1 |
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| 2015 |
Tseng YS, Gurda BL, Chipman P, McKenna R, Afione S, Chiorini JA, Muzyczka N, Olson NH, Baker TS, Kleinschmidt J, Agbandje-McKenna M. Adeno-associated virus serotype 1 (AAV1)- and AAV5-antibody complex structures reveal evolutionary commonalities in parvovirus antigenic reactivity. Journal of Virology. 89: 1794-808. PMID 25410874 DOI: 10.1128/JVI.02710-14 |
1 |
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| 2014 |
Ayuso E, Blouin V, Lock M, McGorray S, Leon X, Alvira MR, Auricchio A, Bucher S, Chtarto A, Clark KR, Darmon C, Doria M, Fountain W, Gao G, Gao K, ... ... Kleinschmidt J, et al. Manufacturing and characterization of a recombinant adeno-associated virus type 8 reference standard material. Human Gene Therapy. 25: 977-87. PMID 25275822 DOI: 10.1089/hum.2014.057 |
1 |
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| 2014 |
Alonso A, Reinz E, Leuchs B, Kleinschmidt J, Fatar M, Geers B, Lentacker I, Hennerici MG, de Smedt SC, Meairs S. Focal delivery of AAV2/1-transgenes into the rat brain by localized ultrasound-induced BBB Opening. Annals of Neurosciences. 21: 22. PMID 25206050 DOI: 10.5214/ans.0972.7531.210107 |
1 |
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| 2013 |
Porwal M, Cohen S, Snoussi K, Popa-Wagner R, Anderson F, Dugot-Senant N, Wodrich H, Dinsart C, Kleinschmidt JA, Panté N, Kann M. Parvoviruses cause nuclear envelope breakdown by activating key enzymes of mitosis. Plos Pathogens. 9: e1003671. PMID 24204256 DOI: 10.1371/journal.ppat.1003671 |
1 |
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| 2013 |
Alonso A, Reinz E, Leuchs B, Kleinschmidt J, Fatar M, Geers B, Lentacker I, Hennerici MG, de Smedt SC, Meairs S. Focal Delivery of AAV2/1-transgenes Into the Rat Brain by Localized Ultrasound-induced BBB Opening. Molecular Therapy. Nucleic Acids. 2: e73. PMID 23423361 DOI: 10.1038/mtna.2012.64 |
1 |
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| 2012 |
Naumer M, Sonntag F, Schmidt K, Nieto K, Panke C, Davey NE, Popa-Wagner R, Kleinschmidt JA. Properties of the adeno-associated virus assembly-activating protein. Journal of Virology. 86: 13038-48. PMID 23015698 DOI: 10.1128/JVI.01675-12 |
1 |
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| 2012 |
Naumer M, Popa-Wagner R, Kleinschmidt JA. Impact of capsid modifications by selected peptide ligands on recombinant adeno-associated virus serotype 2-mediated gene transduction. The Journal of General Virology. 93: 2131-41. PMID 22764318 DOI: 10.1099/vir.0.044735-0 |
1 |
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| 2012 |
Nieto K, Weghofer M, Sehr P, Ritter M, Sedlmeier S, Karanam B, Seitz H, Müller M, Kellner M, Hörer M, Michaelis U, Roden RB, Gissmann L, Kleinschmidt JA. Development of AAVLP(HPV16/31L2) particles as broadly protective HPV vaccine candidate. Plos One. 7: e39741. PMID 22761884 DOI: 10.1371/journal.pone.0039741 |
1 |
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| 2012 |
Raupp C, Naumer M, Müller OJ, Gurda BL, Agbandje-McKenna M, Kleinschmidt JA. The threefold protrusions of adeno-associated virus type 8 are involved in cell surface targeting as well as postattachment processing. Journal of Virology. 86: 9396-408. PMID 22718833 DOI: 10.1128/JVI.00209-12 |
1 |
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| 2012 |
Popa-Wagner R, Porwal M, Kann M, Reuss M, Weimer M, Florin L, Kleinschmidt JA. Impact of VP1-specific protein sequence motifs on adeno-associated virus type 2 intracellular trafficking and nuclear entry. Journal of Virology. 86: 9163-74. PMID 22696661 DOI: 10.1128/JVI.00282-12 |
1 |
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| 2012 |
Popa-Wagner R, Sonntag F, Schmidt K, King J, Kleinschmidt JA. Nuclear translocation of adeno-associated virus type 2 capsid proteins for virion assembly. The Journal of General Virology. 93: 1887-98. PMID 22694902 DOI: 10.1099/vir.0.043232-0 |
1 |
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| 2012 |
Gurda BL, Raupp C, Popa-Wagner R, Naumer M, Olson NH, Ng R, McKenna R, Baker TS, Kleinschmidt JA, Agbandje-McKenna M. Mapping a neutralizing epitope onto the capsid of adeno-associated virus serotype 8. Journal of Virology. 86: 7739-51. PMID 22593150 DOI: 10.1128/JVI.00218-12 |
1 |
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| 2012 |
Nieto K, Stahl-Hennig C, Leuchs B, Müller M, Gissmann L, Kleinschmidt JA. Intranasal vaccination with AAV5 and 9 vectors against human papillomavirus type 16 in rhesus macaques. Human Gene Therapy. 23: 733-41. PMID 22401308 DOI: 10.1089/hum.2011.202 |
1 |
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| 2012 |
Allaume X, El-Andaloussi N, Leuchs B, Bonifati S, Kulkarni A, Marttila T, Kaufmann JK, Nettelbeck DM, Kleinschmidt J, Rommelaere J, Marchini A. Retargeting of rat parvovirus H-1PV to cancer cells through genetic engineering of the viral capsid. Journal of Virology. 86: 3452-65. PMID 22258256 DOI: 10.1128/JVI.06208-11 |
1 |
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| 2012 |
Schinkel S, Bauer R, Bekeredjian R, Stucka R, Rutschow D, Lochmüller H, Kleinschmidt JA, Katus HA, Müller OJ. Long-term preservation of cardiac structure and function after adeno-associated virus serotype 9-mediated microdystrophin gene transfer in mdx mice. Human Gene Therapy. 23: 566-75. PMID 22248393 DOI: 10.1089/hum.2011.017 |
1 |
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| 2012 |
Naumer M, Ying Y, Michelfelder S, Reuter A, Trepel M, Müller OJ, Kleinschmidt JA. Development and validation of novel AAV2 random libraries displaying peptides of diverse lengths and at diverse capsid positions. Human Gene Therapy. 23: 492-507. PMID 22171602 DOI: 10.1089/hum.2011.139 |
1 |
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| 2012 |
Varadi K, Michelfelder S, Korff T, Hecker M, Trepel M, Katus HA, Kleinschmidt JA, Müller OJ. Novel random peptide libraries displayed on AAV serotype 9 for selection of endothelial cell-directed gene transfer vectors. Gene Therapy. 19: 800-9. PMID 21956692 DOI: 10.1038/gt.2011.143 |
1 |
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| 2011 |
Agbandje-McKenna M, Kleinschmidt J. AAV capsid structure and cell interactions. Methods in Molecular Biology (Clifton, N.J.). 807: 47-92. PMID 22034026 DOI: 10.1007/978-1-61779-370-7_3 |
1 |
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| 2011 |
Sonntag F, Köther K, Schmidt K, Weghofer M, Raupp C, Nieto K, Kuck A, Gerlach B, Böttcher B, Müller OJ, Lux K, Hörer M, Kleinschmidt JA. The assembly-activating protein promotes capsid assembly of different adeno-associated virus serotypes. Journal of Virology. 85: 12686-97. PMID 21917944 DOI: 10.1128/JVI.05359-11 |
1 |
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| 2011 |
Michelfelder S, Varadi K, Raupp C, Hunger A, Körbelin J, Pahrmann C, Schrepfer S, Müller OJ, Kleinschmidt JA, Trepel M. Peptide ligands incorporated into the threefold spike capsid domain to re-direct gene transduction of AAV8 and AAV9 in vivo. Plos One. 6: e23101. PMID 21850255 DOI: 10.1371/journal.pone.0023101 |
1 |
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| 2011 |
Gerlach B, Kleinschmidt JA, Böttcher B. Conformational changes in adeno-associated virus type 1 induced by genome packaging. Journal of Molecular Biology. 409: 427-38. PMID 21463638 DOI: 10.1016/j.jmb.2011.03.062 |
1 |
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| 2011 |
Kulozik P, Jones A, Mattijssen F, Rose AJ, Reimann A, Strzoda D, Kleinsorg S, Raupp C, Kleinschmidt J, Müller-Decker K, Wahli W, Sticht C, Gretz N, von Loeffelholz C, Stockmann M, et al. Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia. Cell Metabolism. 13: 389-400. PMID 21459324 DOI: 10.1016/j.cmet.2011.02.011 |
1 |
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| 2011 |
Sellner L, Veldwijk MR, Kleinschmidt JA, Laufs S, Topaly J, Fruehauf S, Zeller WJ, Wenz F. Efficient gene transfer with pseudotyped recombinant adeno-associated viral vectors into human chronic myelogenous leukemia cells. Leukemia & Lymphoma. 52: 483-90. PMID 21323526 DOI: 10.3109/10428194.2010.545460 |
1 |
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| 2011 |
El-Andaloussi N, Endele M, Leuchs B, Bonifati S, Kleinschmidt J, Rommelaere J, Marchini A. Novel adenovirus-based helper system to support production of recombinant parvovirus. Cancer Gene Therapy. 18: 240-9. PMID 21102423 DOI: 10.1038/cgt.2010.73 |
1 |
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| 2011 |
Pleger ST, Shan C, Kszienyk J, Bekeredjian R, Boekstegers P, Leuchs B, Weber C, Kleinschmidt JA, Raake P, Koch WJ, Katus HA, Müller OJ, Most P. Cardiac-targeted AAV9-S10OA1 gene therapy rescues postischemic heart failure in a preclinical large animal model Journal Fur Anasthesie Und Intensivbehandlung. 18: S134-S136. |
1 |
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| 2010 |
Schmitt M, Pawlita M, Kleinschmidt J. Genotyping of AAV plasmid stocks: quality control in adeno-associated virus vector production. Journal of Molecular Microbiology and Biotechnology. 19: 204-12. PMID 21088429 DOI: 10.1159/000321449 |
1 |
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| 2010 |
Sonntag F, Schmidt K, Kleinschmidt JA. A viral assembly factor promotes AAV2 capsid formation in the nucleolus. Proceedings of the National Academy of Sciences of the United States of America. 107: 10220-5. PMID 20479244 DOI: 10.1073/pnas.1001673107 |
1 |
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| 2010 |
Ying Y, Müller OJ, Goehringer C, Leuchs B, Trepel M, Katus HA, Kleinschmidt JA. Heart-targeted adeno-associated viral vectors selected by in vivo biopanning of a random viral display peptide library. Gene Therapy. 17: 980-90. PMID 20393510 DOI: 10.1038/gt.2010.44 |
1 |
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| 2010 |
Veldwijk MR, Sellner L, Stiefelhagen M, Kleinschmidt JA, Laufs S, Topaly J, Fruehauf S, Zeller WJ, Wenz F. Pseudotyped recombinant adeno-associated viral vectors mediate efficient gene transfer into primary human CD34(+) peripheral blood progenitor cells. Cytotherapy. 12: 107-12. PMID 19929455 DOI: 10.3109/14653240903348293 |
1 |
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| 2009 |
Nieto K, Kern A, Leuchs B, Gissmann L, Müller M, Kleinschmidt JA. Combined prophylactic and therapeutic intranasal vaccination against human papillomavirus type-16 using different adeno-associated virus serotype vectors. Antiviral Therapy. 14: 1125-37. PMID 20032542 DOI: 10.3851/IMP1469 |
1 |
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| 2009 |
Stahl-Hennig C, Eisenblätter M, Jasny E, Rzehak T, Tenner-Racz K, Trumpfheller C, Salazar AM, Uberla K, Nieto K, Kleinschmidt J, Schulte R, Gissmann L, Müller M, Sacher A, Racz P, et al. Synthetic double-stranded RNAs are adjuvants for the induction of T helper 1 and humoral immune responses to human papillomavirus in rhesus macaques. Plos Pathogens. 5: e1000373. PMID 19360120 DOI: 10.1371/journal.ppat.1000373 |
1 |
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| 2009 |
Michelfelder S, Kohlschütter J, Skorupa A, Pfennings S, Müller O, Kleinschmidt JA, Trepel M. Successful expansion but not complete restriction of tropism of adeno-associated virus by in vivo biopanning of random virus display peptide libraries. Plos One. 4: e5122. PMID 19357785 DOI: 10.1371/journal.pone.0005122 |
1 |
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| 2009 |
Goehringer C, Rutschow D, Bauer R, Schinkel S, Weichenhan D, Bekeredjian R, Straub V, Kleinschmidt JA, Katus HA, Müller OJ. Prevention of cardiomyopathy in delta-sarcoglycan knockout mice after systemic transfer of targeted adeno-associated viral vectors. Cardiovascular Research. 82: 404-10. PMID 19218289 DOI: 10.1093/cvr/cvp061 |
1 |
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| 2008 |
Stiefelhagen M, Sellner L, Kleinschmidt JA, Jauch A, Laufs S, Wenz F, Zeller WJ, Fruehauf S, Veldwijk MR. Application of a haematopoetic progenitor cell-targeted adeno-associated viral (AAV) vector established by selection of an AAV random peptide library on a leukaemia cell line. Genetic Vaccines and Therapy. 6: 12. PMID 18789140 DOI: 10.1186/1479-0556-6-12 |
1 |
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| 2008 |
Müller OJ, Schinkel S, Kleinschmidt JA, Katus HA, Bekeredjian R. Augmentation of AAV-mediated cardiac gene transfer after systemic administration in adult rats. Gene Therapy. 15: 1558-65. PMID 18615116 DOI: 10.1038/gt.2008.111 |
1 |
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| 2008 |
Sellner L, Stiefelhagen M, Kleinschmidt JA, Laufs S, Wenz F, Fruehauf S, Zeller WJ, Veldwijk MR. Generation of efficient human blood progenitor-targeted recombinant adeno-associated viral vectors (AAV) by applying an AAV random peptide library on primary human hematopoietic progenitor cells. Experimental Hematology. 36: 957-64. PMID 18495326 DOI: 10.1016/j.exphem.2008.03.007 |
1 |
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| 2008 |
Krüger L, Eskerski H, Dinsart C, Cornelis J, Rommelaere J, Haberkorn U, Kleinschmidt JA. Augmented transgene expression in transformed cells using a parvoviral hybrid vector. Cancer Gene Therapy. 15: 252-67. PMID 18202715 DOI: 10.1038/sj.cgt.7701113 |
1 |
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| 2008 |
Raake PW, Hinkel R, Müller S, Delker S, Kreuzpointner R, Kupatt C, Katus HA, Kleinschmidt JA, Boekstegers P, Müller OJ. Cardio-specific long-term gene expression in a porcine model after selective pressure-regulated retroinfusion of adeno-associated viral (AAV) vectors. Gene Therapy. 15: 12-7. PMID 17943147 DOI: 10.1038/sj.gt.3303035 |
1 |
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| 2008 |
Bekeredjian R, Schinkel S, Katus HA, Kleinschmidt J, Mayer C, Müller OJ. Ultrasound targeted microbubble destruction augments AAV-mediated cardiac gene transfer in rats Proceedings of the Institute of Acoustics. 30: 399-401. |
1 |
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| 2007 |
Michelfelder S, Lee MK, deLima-Hahn E, Wilmes T, Kaul F, Müller O, Kleinschmidt JA, Trepel M. Vectors selected from adeno-associated viral display peptide libraries for leukemia cell-targeted cytotoxic gene therapy. Experimental Hematology. 35: 1766-76. PMID 17920758 DOI: 10.1016/j.exphem.2007.07.018 |
1 |
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| 2007 |
Kuck D, Kern A, Kleinschmidt JA. Development of AAV serotype-specific ELISAs using novel monoclonal antibodies. Journal of Virological Methods. 140: 17-24. PMID 17126418 DOI: 10.1016/j.jviromet.2006.10.005 |
1 |
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| 2006 |
Sonntag F, Bleker S, Leuchs B, Fischer R, Kleinschmidt JA. Adeno-associated virus type 2 capsids with externalized VP1/VP2 trafficking domains are generated prior to passage through the cytoplasm and are maintained until uncoating occurs in the nucleus. Journal of Virology. 80: 11040-54. PMID 16956943 DOI: 10.1128/JVI.01056-06 |
1 |
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| 2006 |
Waterkamp DA, Müller OJ, Ying Y, Trepel M, Kleinschmidt JA. Isolation of targeted AAV2 vectors from novel virus display libraries. The Journal of Gene Medicine. 8: 1307-19. PMID 16955542 DOI: 10.1002/jgm.967 |
1 |
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| 2006 |
Kuck D, Lau T, Leuchs B, Kern A, Müller M, Gissmann L, Kleinschmidt JA. Intranasal vaccination with recombinant adeno-associated virus type 5 against human papillomavirus type 16 L1. Journal of Virology. 80: 2621-30. PMID 16501072 DOI: 10.1128/JVI.80.6.2621-2630.2006 |
1 |
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| 2006 |
Müller OJ, Leuchs B, Pleger ST, Grimm D, Franz WM, Katus HA, Kleinschmidt JA. Improved cardiac gene transfer by transcriptional and transductional targeting of adeno-associated viral vectors. Cardiovascular Research. 70: 70-8. PMID 16448634 DOI: 10.1016/j.cardiores.2005.12.017 |
1 |
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| 2006 |
Kuck D, Leder C, Kern A, Müller M, Piuko K, Gissmann L, Kleinschmidt JA. Efficiency of HPV 16 L1/E7 DNA immunization: influence of cellular localization and capsid assembly. Vaccine. 24: 2952-65. PMID 16414157 DOI: 10.1016/j.vaccine.2005.12.023 |
1 |
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| 2006 |
Bleker S, Pawlita M, Kleinschmidt JA. Impact of capsid conformation and Rep-capsid interactions on adeno-associated virus type 2 genome packaging. Journal of Virology. 80: 810-20. PMID 16378983 DOI: 10.1128/JVI.80.2.810-820.2006 |
1 |
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| 2005 |
Kronenberg S, Böttcher B, von der Lieth CW, Bleker S, Kleinschmidt JA. A conformational change in the adeno-associated virus type 2 capsid leads to the exposure of hidden VP1 N termini. Journal of Virology. 79: 5296-303. PMID 15827144 DOI: 10.1128/JVI.79.9.5296-5303.2005 |
1 |
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| 2005 |
Bleker S, Sonntag F, Kleinschmidt JA. Mutational analysis of narrow pores at the fivefold symmetry axes of adeno-associated virus type 2 capsids reveals a dual role in genome packaging and activation of phospholipase A2 activity. Journal of Virology. 79: 2528-40. PMID 15681453 DOI: 10.1128/JVI.79.4.2528-2540.2005 |
1 |
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| 2004 |
Yoon-Robarts M, Blouin AG, Bleker S, Kleinschmidt JA, Aggarwal AK, Escalante CR, Linden RM. Residues within the B' motif are critical for DNA binding by the superfamily 3 helicase Rep40 of adeno-associated virus type 2. The Journal of Biological Chemistry. 279: 50472-81. PMID 15371437 DOI: 10.1074/jbc.M403900200 |
1 |
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| 2004 |
Schoensiegel F, Paschen A, Sieger S, Eskerski H, Mier W, Rothfels H, Kleinschmidt J, Schadendorf D, Haberkorn U. MIA (melanoma inhibitory activity) promoter mediated tissue-specific suicide gene therapy of malignant melanoma. Cancer Gene Therapy. 11: 408-18. PMID 15118759 DOI: 10.1038/sj.cgt.7700721 |
1 |
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| 2004 |
Sieger S, Jiang S, Kleinschmidt J, Eskerski H, Schönsiegel F, Altmann A, Mier W, Haberkorn U. Tumor-specific gene expression using regulatory elements of the glucose transporter isoform 1 gene. Cancer Gene Therapy. 11: 41-51. PMID 14681725 DOI: 10.1038/sj.cgt.7700654 |
1 |
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| 2003 |
Huttner NA, Girod A, Perabo L, Edbauer D, Kleinschmidt JA, Büning H, Hallek M. Genetic modifications of the adeno-associated virus type 2 capsid reduce the affinity and the neutralizing effects of human serum antibodies. Gene Therapy. 10: 2139-47. PMID 14625569 DOI: 10.1038/sj.gt.3302123 |
1 |
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| 2003 |
Kern A, Schmidt K, Leder C, Müller OJ, Wobus CE, Bettinger K, Von der Lieth CW, King JA, Kleinschmidt JA. Identification of a heparin-binding motif on adeno-associated virus type 2 capsids. Journal of Virology. 77: 11072-81. PMID 14512555 DOI: 10.1128/JVI.77.20.11072-11081.2003 |
1 |
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| 2003 |
Müller OJ, Kaul F, Weitzman MD, Pasqualini R, Arap W, Kleinschmidt JA, Trepel M. Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors. Nature Biotechnology. 21: 1040-6. PMID 12897791 DOI: 10.1038/nbt856 |
1 |
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| 2003 |
Grimm D, Kay MA, Kleinschmidt JA. Helper virus-free, optically controllable, and two-plasmid-based production of adeno-associated virus vectors of serotypes 1 to 6. Molecular Therapy : the Journal of the American Society of Gene Therapy. 7: 839-50. PMID 12788658 DOI: 10.1016/S1525-0016(03)00095-9 |
1 |
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| 2002 |
Rohr UP, Kronenwett R, Grimm D, Kleinschmidt J, Haas R. Primary human cells differ in their susceptibility to rAAV-2-mediated gene transfer and duration of reporter gene expression. Journal of Virological Methods. 105: 265-75. PMID 12270659 DOI: 10.1016/S0166-0934(02)00117-9 |
1 |
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| 2002 |
Girod A, Wobus CE, Zádori Z, Ried M, Leike K, Tijssen P, Kleinschmidt JA, Hallek M. The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity. The Journal of General Virology. 83: 973-8. PMID 11961250 |
1 |
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| 2001 |
Kronenberg S, Kleinschmidt JA, Böttcher B. Electron cryo-microscopy and image reconstruction of adeno-associated virus type 2 empty capsids. Embo Reports. 2: 997-1002. PMID 11713191 DOI: 10.1093/embo-reports/kve234 |
1 |
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| 2001 |
Leder C, Kleinschmidt JA, Wiethe C, Müller M. Enhancement of capsid gene expression: preparing the human papillomavirus type 16 major structural gene L1 for DNA vaccination purposes. Journal of Virology. 75: 9201-9. PMID 11533183 DOI: 10.1128/JVI.75.19.9201-9209.2001 |
1 |
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| 2001 |
Jiang S, Altmann A, Grimm D, Kleinschmidt JA, Schilling T, Germann C, Haberkorn U. Tissue-specific gene expression in medullary thyroid carcinoma cells employing calcitonin regulatory elements and AAV vectors. Cancer Gene Therapy. 8: 469-72. PMID 11498767 DOI: 10.1038/sj.cgt.7700327 |
1 |
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| 2001 |
King JA, Dubielzig R, Grimm D, Kleinschmidt JA. DNA helicase-mediated packaging of adeno-associated virus type 2 genomes into preformed capsids. The Embo Journal. 20: 3282-91. PMID 11406604 DOI: 10.1093/emboj/20.12.3282 |
1 |
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| 2000 |
Wobus CE, Hügle-Dörr B, Girod A, Petersen G, Hallek M, Kleinschmidt JA. Monoclonal antibodies against the adeno-associated virus type 2 (AAV-2) capsid: epitope mapping and identification of capsid domains involved in AAV-2-cell interaction and neutralization of AAV-2 infection. Journal of Virology. 74: 9281-93. PMID 10982375 DOI: 10.1128/JVI.74.19.9281-9293.2000 |
1 |
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| 2000 |
Chadeuf G, Favre D, Tessier J, Provost N, Nony P, Kleinschmidt J, Moullier P, Salvetti A. Efficient recombinant adeno-associated virus production by a stable rep-cap HeLa cell line correlates with adenovirus-induced amplification of the integrated rep-cap genome. The Journal of Gene Medicine. 2: 260-8. PMID 10953917 DOI: 10.1002/1521-2254(200007/08)2:4<260::AID-JGM111>3.0.CO;2-8 |
1 |
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| 2000 |
Kunke D, Grimm D, Denger S, Kreuzer J, Delius H, Komitowski D, Kleinschmidt JA. Preclinical study on gene therapy of cervical carcinoma using adeno-associated virus vectors. Cancer Gene Therapy. 7: 766-77. PMID 10830724 DOI: 10.1038/sj.cgt.7700178 |
1 |
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| 2000 |
Veldwijk MR, Fruehauf S, Schiedlmeier B, Kleinschmidt JA, Zeller WJ. Differential expression of a recombinant adeno-associated virus 2 vector in human CD34+ cells and breast cancer cells. Cancer Gene Therapy. 7: 597-604. PMID 10811478 DOI: 10.1038/sj.cgt.7700159 |
1 |
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| 1999 |
Grimm D, Kleinschmidt JA. Progress in adeno-associated virus type 2 vector production: promises and prospects for clinical use. Human Gene Therapy. 10: 2445-50. PMID 10543610 DOI: 10.1089/10430349950016799 |
1 |
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| 1999 |
Veldwijk MR, Schiedlmeier B, Kleinschmidt JA, Zeller WJ, Fruehauf S. Superior gene transfer into solid tumour cells than into human mobilised peripheral blood progenitor cells using helpervirus-free adeno-associated viral vector stocks. European Journal of Cancer (Oxford, England : 1990). 35: 1136-42. PMID 10533460 DOI: 10.1016/S0959-8049(99)00075-1 |
1 |
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| 1999 |
Dubielzig R, King JA, Weger S, Kern A, Kleinschmidt JA. Adeno-associated virus type 2 protein interactions: formation of pre-encapsidation complexes. Journal of Virology. 73: 8989-98. PMID 10516005 |
1 |
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| 1999 |
Girod A, Ried M, Wobus C, Lahm H, Leike K, Kleinschmidt J, Deléage G, Hallek M. Genetic capsid modifications allow efficient re-targeting of adeno-associated virus type 2. Nature Medicine. 5: 1052-6. PMID 10470084 DOI: 10.1038/12491 |
1 |
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| 1999 |
Grimm D, Kern A, Pawlita M, Ferrari F, Samulski R, Kleinschmidt J. Titration of AAV-2 particles via a novel capsid ELISA: packaging of genomes can limit production of recombinant AAV-2. Gene Therapy. 6: 1322-30. PMID 10455443 DOI: 10.1038/sj.gt.3300946 |
1 |
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| 1999 |
Hörster A, Teichmann B, Hormes R, Grimm D, Kleinschmidt J, Sczakiel G. Recombinant AAV-2 harboring gfp-antisense/ribozyme fusion sequences monitor transduction, gene expression, and show anti-HIV-1 efficacy. Gene Therapy. 6: 1231-8. PMID 10455431 DOI: 10.1038/sj.gt.3300955 |
1 |
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| 1999 |
Hermens WT, ter Brake O, Dijkhuizen PA, Sonnemans MA, Grimm D, Kleinschmidt JA, Verhaagen J. Purification of recombinant adeno-associated virus by iodixanol gradient ultracentrifugation allows rapid and reproducible preparation of vector stocks for gene transfer in the nervous system. Human Gene Therapy. 10: 1885-91. PMID 10446928 DOI: 10.1089/10430349950017563 |
1 |
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| 1999 |
Bartlett JS, Kleinschmidt J, Boucher RC, Samulski RJ. Targeted adeno-associated virus vector transduction of nonpermissive cells mediated by a bispecific F(ab'gamma)2 antibody. Nature Biotechnology. 17: 181-6. PMID 10052356 DOI: 10.1038/6185 |
1 |
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| 1999 |
Weger S, Wendland M, Kleinschmidt JA, Heilbronn R. The adeno-associated virus type 2 regulatory proteins rep78 and rep68 interact with the transcriptional coactivator PC4. Journal of Virology. 73: 260-9. PMID 9847329 |
1 |
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| 1998 |
Grimm D, Kern A, Rittner K, Kleinschmidt JA. Novel tools for production and purification of recombinant adenoassociated virus vectors. Human Gene Therapy. 9: 2745-60. PMID 9874273 DOI: 10.1089/hum.1998.9.18-2745 |
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| 1997 |
Weger S, Wistuba A, Grimm D, Kleinschmidt JA. Control of adeno-associated virus type 2 cap gene expression: relative influence of helper virus, terminal repeats, and Rep proteins. Journal of Virology. 71: 8437-47. PMID 9343200 |
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| 1997 |
Hermanns J, Schulze A, Jansen-Db1urr P, Kleinschmidt JA, Schmidt R, zur Hausen H. Infection of primary cells by adeno-associated virus type 2 results in a modulation of cell cycle-regulating proteins. Journal of Virology. 71: 6020-7. PMID 9223493 |
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| 1997 |
Steinbach S, Wistuba A, Bock T, Kleinschmidt JA. Assembly of adeno-associated virus type 2 capsids in vitro. The Journal of General Virology. 78: 1453-62. PMID 9191943 |
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| 1997 |
Wistuba A, Kern A, Weger S, Grimm D, Kleinschmidt JA. Subcellular compartmentalization of adeno-associated virus type 2 assembly. Journal of Virology. 71: 1341-52. PMID 8995658 |
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| 1996 |
Klein-Bauernschmitt P, von Knebel Doeberitz M, Ehrbar M, Geletneky K, Kleinschmidt J, Schlehofer JR. Improved efficacy of chemotherapy by parvovirus-mediated sensitisation of human tumour cells. European Journal of Cancer (Oxford, England : 1990). 32: 1774-80. PMID 8983289 DOI: 10.1016/0959-8049(96)00175-X |
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| 1996 |
Klein-Bauernschmitt P, Von Knebel Doeberitz M, Ehrbar M, Geletneky K, Kleinschmidt J. Improved efficacy of chemotherapy by parvovirus-mediated sensitisation of human tumour cells European Journal of Cancer Part A. 32: 1766-1773. |
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| 1995 |
Kleinschmidt JA, Möhler M, Weindler FW, Heilbronn R. Sequence elements of the adeno-associated virus rep gene required for suppression of herpes-simplex-virus-induced DNA amplification. Virology. 206: 254-62. PMID 7831779 DOI: 10.1016/S0042-6822(95)80040-9 |
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| 1995 |
Hörer M, Weger S, Butz K, Hoppe-Seyler F, Geisen C, Kleinschmidt JA. Mutational analysis of adeno-associated virus Rep protein-mediated inhibition of heterologous and homologous promoters. Journal of Virology. 69: 5485-96. PMID 7636994 |
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| 1995 |
Wistuba A, Weger S, Kern A, Kleinschmidt JA. Intermediates of adeno-associated virus type 2 assembly: identification of soluble complexes containing Rep and Cap proteins. Journal of Virology. 69: 5311-9. PMID 7636974 |
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| 1995 |
Hölscher C, Kleinschmidt JA, Bürkle A. High-level expression of adeno-associated virus (AAV) Rep78 or Rep68 protein is sufficient for infectious-particle formation by a rep-negative AAV mutant. Journal of Virology. 69: 6880-5. PMID 7474103 |
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| 1994 |
Peters JM, Franke WW, Kleinschmidt JA. Distinct 19 S and 20 S subcomplexes of the 26 S proteasome and their distribution in the nucleus and the cytoplasm. The Journal of Biological Chemistry. 269: 7709-18. PMID 8125997 |
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| 1994 |
Ruffing M, Heid H, Kleinschmidt JA. Mutations in the carboxy terminus of adeno-associated virus 2 capsid proteins affect viral infectivity: lack of an RGD integrin-binding motif. The Journal of General Virology. 75: 3385-92. PMID 7996133 |
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| 1994 |
Hölscher C, Hörer M, Kleinschmidt JA, Zentgraf H, Bürkle A, Heilbronn R. Cell lines inducibly expressing the adeno-associated virus (AAV) rep gene: requirements for productive replication of rep-negative AAV mutants. Journal of Virology. 68: 7169-77. PMID 7933099 |
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| 1993 |
Peters JM, Cejka Z, Harris JR, Kleinschmidt JA, Baumeister W. Structural features of the 26 S proteasome complex. Journal of Molecular Biology. 234: 932-7. PMID 8263938 DOI: 10.1006/jmbi.1993.1646 |
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| 1993 |
Soeding B, Kleinschmidt J, Teuber M, Neve H. Assessment of abilities of conjugal transfer and stability of pAMβ1 in dairy lactobacilli with emphasis on thermophilic and nonstarter lactobacilli Systematic and Applied Microbiology. 16: 296-302. |
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| 1993 |
Kleinschmidt J, Soeding B, Teuber M, Neve H. Evaluation of horizontal and vertical gene transfer and stability of heterologous, DNA in Streptococcus thermophilus isolated from yogurt and yogurt starter cultures Systematic and Applied Microbiology. 16: 287-295. |
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| 1992 |
Janzen T, Kleinschmidt J, Neve H, Geis A. Sequencing and characterization of pST1, a cryptic plasmid from Streptococcus thermophilus. Fems Microbiology Letters. 74: 175-80. PMID 1526450 DOI: 10.1016/0378-1097(92)90425-N |
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| 1992 |
Blank T, Trendelenburg M, Kleinschmidt JA. Reactivation of DNA replication in erythrocyte nuclei by Xenopus egg extract involves energy-dependent chromatin decondensation and changes in histone phosphorylation. Experimental Cell Research. 202: 224-32. PMID 1397077 DOI: 10.1016/0014-4827(92)90069-K |
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| 1992 |
Ruffing M, Zentgraf H, Kleinschmidt JA. Assembly of viruslike particles by recombinant structural proteins of adeno-associated virus type 2 in insect cells. Journal of Virology. 66: 6922-30. PMID 1331503 |
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| 1992 |
Rittner K, Heilbronn R, Kleinschmidt JA, Sczakiel G. Adeno-associated virus type 2-mediated inhibition of human immunodeficiency virus type 1 (HIV-1) replication: involvement of p78rep/p68rep and the HIV-1 long terminal repeat. The Journal of General Virology. 73: 2977-81. PMID 1331299 |
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| 1991 |
Höger TH, Krohne G, Kleinschmidt JA. Interaction of Xenopus lamins A and LII with chromatin in vitro mediated by a sequence element in the carboxyterminal domain. Experimental Cell Research. 197: 280-9. PMID 1959562 DOI: 10.1016/0014-4827(91)90434-V |
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| 1991 |
Kleinschmidt JA, Steinbeisser H. DNA-dependent phosphorylation of histone H2A.X during nucleosome assembly in Xenopus laevis oocytes: involvement of protein phosphorylation in nucleosome spacing. The Embo Journal. 10: 3043-50. PMID 1915279 |
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| 1991 |
Peters JM, Harris JR, Kleinschmidt JA. Ultrastructure of the approximately 26S complex containing the approximately 20S cylinder particle (multicatalytic proteinase/proteasome). European Journal of Cell Biology. 56: 422-32. PMID 1802724 |
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| 1991 |
Rittner K, Heilbronn R, Kleinschmidt JA, Oelze I, Sczakiel G. Replication of the human immunodeficiency virus type 1 is inhibited by the adeno-associated virus rep gene. Biochemical Society Transactions. 19: 438S. PMID 1665443 |
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| 1990 |
Kleinschmidt JA, Seiter A, Zentgraf H. Nucleosome assembly in vitro: separate histone transfer and synergistic interaction of native histone complexes purified from nuclei of Xenopus laevis oocytes. The Embo Journal. 9: 1309-18. PMID 2323341 |
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| 1989 |
Ankenbauer T, Kleinschmidt JA, Walsh MJ, Weiner OH, Franke WW. Identification of a widespread nuclear actin binding protein. Nature. 342: 822-5. PMID 2689884 DOI: 10.1038/342822a0 |
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| 1988 |
Kleinschmidt JA, Seiter A. Identification of domains involved in nuclear uptake and histone binding of protein N1 of Xenopus laevis. The Embo Journal. 7: 1605-14. PMID 3168999 |
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| 1988 |
Kleinschmidt JA, Escher C, Wolf DH. Proteinase yscE of yeast shows homology with the 20 S cylinder particles of Xenopus laevis. Febs Letters. 239: 35-40. PMID 3053244 DOI: 10.1016/0014-5793(88)80540-4 |
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| 1988 |
Ankenbauer T, Kleinschmidt JA, Vandekerckhove J, Franke WW. Proteins regulating actin assembly in oogenesis and early embryogenesis of Xenopus laevis: gelsolin is the major cytoplasmic actin-binding protein. The Journal of Cell Biology. 107: 1489-98. PMID 2844829 |
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| 1987 |
Kleinschmidt JA, Buhl WJ. The ∼ 20 S cylinder particles of Xenopus laevis: Experimental findings and open questions Molecular Biology Reports. 12: 229. DOI: 10.1007/BF00356913 |
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| 1986 |
Kleinschmidt JA, Dingwall C, Maier G, Franke WW. Molecular characterization of a karyophilic, histone-binding protein: cDNA cloning, amino acid sequence and expression of nuclear protein N1/N2 of Xenopus laevis. The Embo Journal. 5: 3547-52. PMID 3549279 |
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| 1985 |
Kleinschmidt JA, Fortkamp E, Krohne G, Zentgraf H, Franke WW. Co-existence of two different types of soluble histone complexes in nuclei of Xenopus laevis oocytes. The Journal of Biological Chemistry. 260: 1166-76. PMID 2981836 |
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| 1983 |
Hügle B, Kleinschmidt JA, Franke WW. The 22 S cylinder particles of Xenopus laevis. II. Immunological characterization and localization of their proteins in tissues and cultured cells. European Journal of Cell Biology. 32: 157-63. PMID 6667692 |
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| 1983 |
Kleinschmidt JA, Hügle B, Grund C, Franke WW. The 22 S cylinder particles of Xenopus laevis. I. Biochemical and electron microscopic characterization. European Journal of Cell Biology. 32: 143-56. PMID 6667691 |
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| 1983 |
Kleinschmidt JA, Scheer U, Dabauvalle MC, Bustin M, Franke WW. High mobility group proteins of amphibian oocytes: a large storage pool of a soluble high mobility group-1-like protein and involvement in transcriptional events. The Journal of Cell Biology. 97: 838-48. PMID 6224801 DOI: 10.1083/jcb.97.3.838 |
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| 1982 |
Kleinschmidt JA, Franke WW. Soluble acidic complexes containing histones H3 and H4 in nuclei of Xenopus laevis oocytes. Cell. 29: 799-809. PMID 6891289 DOI: 10.1016/0092-8674(82)90442-1 |
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| 1982 |
Krohne G, Stick R, Kleinschmidt JA, Moll R, Franke WW, Hausen P. Immunological localization of a major karyoskeletal protein in nucleoli of oocytes and somatic cells of Xenopus laevis. The Journal of Cell Biology. 94: 749-54. PMID 6752154 DOI: 10.1083/jcb.94.3.749 |
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| 1982 |
Williams MA, Kleinschmidt JA, Krohne G, Franke WW. Argyrophilic nuclear and nucleolar proteins of Xenopus laevis oocytes identified by gel electrophoresis. Experimental Cell Research. 137: 341-51. PMID 6173244 DOI: 10.1016/0014-4827(82)90035-0 |
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| 1981 |
Franke WW, Kleinschmidt JA, Spring H, Krohne G, Grund C, Trendelenburg MF, Stoehr M, Scheer U. A nucleolar skeleton of protein filaments demonstrated in amplified nucleoli of Xenopus laevis. The Journal of Cell Biology. 90: 289-99. PMID 6169728 DOI: 10.1083/jcb.90.2.289 |
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