Mark A. Kay, MD PhD - Publications

Affiliations: 
Stanford University, Palo Alto, CA 

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Year Citation  Score
2023 Gonzalez-Sandoval A, Pekrun K, Tsuji S, Zhang F, Hung KL, Chang HY, Kay MA. The AAV capsid can influence the epigenetic marking of rAAV delivered episomal genomes in a species dependent manner. Nature Communications. 14: 2448. PMID 37117181 DOI: 10.1038/s41467-023-38106-3  0.349
2023 Puzzo F, Zhang C, Powell Gray B, Zhang F, Sullenger BA, Kay MA. Aptamer-programmable adeno-associated viral vectors as a novel platform for cell-specific gene transfer. Molecular Therapy. Nucleic Acids. 31: 383-397. PMID 36817723 DOI: 10.1016/j.omtn.2023.01.007  0.379
2022 Sabatino DE, Bushman CFD, Chandler RJ, Crystal RG, Davidson BL, Dolmetsch R, Eggan KC, Gao G, Gil-Farina I, Kay MA, McCarty DM, Montini E, Ndu A, Yuan J. Evaluating the State of the Science for Adeno-Associated Virus (AAV) Integration:An Integrated Perspective. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 35690906 DOI: 10.1016/j.ymthe.2022.06.004  0.353
2022 Tsuji S, Stephens CJ, Bortolussi G, Zhang F, Baj G, Jang H, de Alencastro G, Muro AF, Pekrun K, Kay MA. Fludarabine increases nuclease-free AAV- and CRISPR/Cas9-mediated homologous recombination in mice. Nature Biotechnology. PMID 35393561 DOI: 10.1038/s41587-022-01240-2  0.369
2022 Lisjak M, De Caneva A, Marais T, Barbon E, Biferi MG, Porro F, Barzel A, Zentilin L, Kay MA, Mingozzi F, Muro AF. Promoterless Gene Targeting Approach Combined to CRISPR/Cas9 Efficiently Corrects Hemophilia B Phenotype in Neonatal Mice. Frontiers in Genome Editing. 4: 785698. PMID 35359664 DOI: 10.3389/fgeed.2022.785698  0.371
2020 Chandler RJ, Venturoni LE, Liao J, Hubbard BT, Schneller JL, Hoffmann V, Gordo S, Zang S, Ko CW, Chau N, Chiang K, Kay MA, Barzel A, Venditti CP. Promoterless, nuclease-free genome editing confers a growth advantage for corrected hepatocytes in mice with methylmalonic acidemia. Hepatology (Baltimore, Md.). PMID 32976669 DOI: 10.1002/hep.31570  0.369
2020 Kim HK, Yeom JH, Kay MA. Transfer RNA-Derived Small RNAs: Another Layer of Gene Regulation and Novel Targets for Disease Therapeutics. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 32956625 DOI: 10.1016/J.Ymthe.2020.09.013  0.397
2020 Course MM, Gudsnuk K, Smukowski SN, Winston K, Desai N, Ross JP, Sulovari A, Bourassa CV, Spiegelman D, Couthouis J, Yu CE, Tsuang DW, Jayadev S, Kay MA, Gitler AD, et al. Evolution of a Human-Specific Tandem Repeat Associated with ALS. American Journal of Human Genetics. PMID 32750315 DOI: 10.1016/J.Ajhg.2020.07.004  0.333
2020 Su Y, Walker JR, Park Y, Smith TP, Liu LX, Hall MP, Labanieh L, Hurst R, Wang DC, Encell LP, Kim N, Zhang F, Kay MA, Casey KM, Majzner RG, et al. Novel NanoLuc substrates enable bright two-population bioluminescence imaging in animals. Nature Methods. PMID 32661427 DOI: 10.1038/S41592-020-0889-6  0.316
2020 de Alencastro G, Pekrun K, Valdmanis P, Tiffany M, Xu J, Kay MA. Tracking adeno-associated virus capsid evolution by high-throughput sequencing. Human Gene Therapy. PMID 32024384 DOI: 10.1089/Hum.2019.339  0.404
2020 Kim HK, Xu J, Chu K, Park H, jang H, Li P, Valdmanis P, Zhang Q, Kay M. Abstract LB-343: A Leu(CAG)-tRNA derived small RNA regulates ribosomal protein S28 after translation initiation in both human and mouse liver cancers Cancer Research. 80. DOI: 10.1158/1538-7445.Am2020-Lb-343  0.373
2020 Kay MA. The Role of tRNA Derived Small RNAs in Gene Regulation in Normal Tissues and Cancer The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.00158  0.335
2019 Kim HK, Xu J, Chu K, Park H, Jang H, Li P, Valdmanis PN, Zhang QC, Kay MA. A tRNA-Derived Small RNA Regulates Ribosomal Protein S28 Protein Levels after Translation Initiation in Humans and Mice. Cell Reports. 29: 3816-3824.e4. PMID 31851915 DOI: 10.1016/J.Celrep.2019.11.062  0.347
2019 Pekrun K, De Alencastro G, Luo QJ, Liu J, Kim Y, Nygaard S, Galivo F, Zhang F, Song R, Tiffany MR, Xu J, Hebrok M, Grompe M, Kay MA. Using a barcoded AAV capsid library to select for clinically relevant gene therapy vectors. Jci Insight. 4. PMID 31723052 DOI: 10.1172/Jci.Insight.131610  0.447
2019 Zaleta-Rivera K, Dainis A, Ribeiro AJS, Sanchez Cordero P, Rubio G, Shang C, Liu J, Finsterbach T, Parikh VN, Sutton S, Seo K, Sinha N, Jain N, Huang Y, Hajjar RJ, ... Kay MA, et al. Allele-Specific Silencing Ameliorates Restrictive Cardiomyopathy Due to a Human Myosin Regulatory Light Chain Mutation. Circulation. PMID 31315475 DOI: 10.1161/Circulationaha.118.036965  0.319
2019 De Caneva A, Porro F, Bortolussi G, Sola R, Lisjak M, Barzel A, Giacca M, Kay MA, Vlahoviček K, Zentilin L, Muro AF. Coupling AAV-mediated promoterless gene targeting to SaCas9 nuclease to efficiently correct liver metabolic diseases. Jci Insight. 5. PMID 31211694 DOI: 10.1172/Jci.Insight.128863  0.475
2018 Valdmanis PN, Kim HK, Chu K, Zhang F, Xu J, Munding EM, Shen J, Kay MA. miR-122 removal in the liver activates imprinted microRNAs and enables more effective microRNA-mediated gene repression. Nature Communications. 9: 5321. PMID 30552326 DOI: 10.1038/S41467-018-07786-7  0.324
2018 Kim HK, Fuchs G, Wang S, Wei W, Zhang Y, Park H, Roy-Chaudhuri B, Li P, Xu J, Chu K, Zhang F, Chua M, So S, Zhang C, Sarnow P, ... Kay MA, et al. Abstract LB-390: A transfer RNA derived small RNA affects translation in rapidly dividing cells and a target for hepatocellular carcinoma Cancer Research. 78. DOI: 10.1158/1538-7445.Am2018-Lb-390  0.393
2017 Winters IP, Chiou SH, Paulk NK, McFarland CD, Lalgudi PV, Ma RK, Lisowski L, Connolly AJ, Petrov DA, Kay MA, Winslow MM. Multiplexed in vivo homology-directed repair and tumor barcoding enables parallel quantification of Kras variant oncogenicity. Nature Communications. 8: 2053. PMID 29233960 DOI: 10.1038/S41467-017-01519-Y  0.309
2017 Puzzo F, Colella P, Biferi MG, Bali D, Paulk NK, Vidal P, Collaud F, Simon-Sola M, Charles S, Hardet R, Leborgne C, Meliani A, Cohen-Tannoudji M, Astord S, Gjata B, ... ... Kay MA, et al. Rescue of Pompe disease in mice by AAV-mediated liver delivery of secretable acid α-glucosidase. Science Translational Medicine. 9. PMID 29187643 DOI: 10.1126/Scitranslmed.Aam6375  0.429
2017 Kim HK, Fuchs G, Wang S, Wei W, Zhang Y, Park H, Roy-Chaudhuri B, Li P, Xu J, Chu K, Zhang F, Chua MS, So S, Zhang QC, Sarnow P, ... Kay MA, et al. A transfer-RNA-derived small RNA regulates ribosome biogenesis. Nature. 552: 57-62. PMID 29186115 DOI: 10.1038/Nature25005  0.357
2017 Paulk NK, Pekrun K, Zhu E, Nygaard S, Li B, Xu J, Chu K, Leborgne C, Dane AP, Haft A, Zhang Y, Zhang F, Morton C, Valentine MB, Davidoff AM, ... ... Kay MA, et al. Bioengineered AAV Capsids with Combined High Human Liver Transduction In Vivo and Unique Humoral Seroreactivity. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 29055620 DOI: 10.1016/J.Ymthe.2017.09.021  0.423
2017 Borel F, Tang Q, Gernoux G, Greer C, Wang Z, Barzel A, Kay MA, Shultz LD, Greiner DL, Flotte TR, Brehm MA, Mueller C. Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of α-1 Antitrypsin Deficiency. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 29032169 DOI: 10.1016/J.Ymthe.2017.09.020  0.45
2017 Porro F, Bortolussi G, Barzel A, De Caneva A, Iaconcig A, Vodret S, Zentilin L, Kay MA, Muro AF. Promoterless gene targeting without nucleases rescues lethality of a Crigler-Najjar syndrome mouse model. Embo Molecular Medicine. PMID 28751579 DOI: 10.15252/Emmm.201707601  0.438
2017 Lu J, Zhang F, Fire AZ, Kay MA. Sequence-Modified Antibiotic Resistance Genes Provide Sustained Plasmid-Mediated Transgene Expression in Mammals. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28365028 DOI: 10.1016/J.Ymthe.2017.03.003  0.467
2017 Valdmanis P, Kay MA. Future of rAAV gene therapy: Platform for RNAi, Gene Editing and Beyond. Human Gene Therapy. PMID 28073291 DOI: 10.1089/Hum.2016.171  0.439
2017 Colella P, Puzzo F, Biferi M, Bali D, Paulk N, Vidal P, Collaud F, Simon-Sola M, Charles S, Hardet R, Leborgne C, Sellier P, Wittenberghe Lv, Boisgerault F, Barkats M, ... ... Kay M, et al. Whole-body rescue of Pompe disease with AAV liver delivery of engineered secretable GAA transgenes Neuromuscular Disorders. 27. DOI: 10.1016/J.Nmd.2017.06.543  0.332
2016 Wang Y, Pryputniewicz-Dobrinska D, Nagy EÉ, Kaufman CD, Singh M, Yant S, Wang J, Dalda A, Kay MA, Ivics Z, Izsvák Z. Regulated complex assembly safeguards the fidelity of Sleeping Beauty transposition. Nucleic Acids Research. PMID 27913727 DOI: 10.1093/Nar/Gkw1164  0.35
2016 Lu J, Williams JA, Luke J, Zhang F, Chu K, Kay MA. A 5'non-coding exon containing engineered intron enhances transgene expression from recombinant AAV vectors in vivo. Human Gene Therapy. PMID 27903072 DOI: 10.1089/hum.2016.140  0.366
2016 Nygaard S, Barzel A, Haft A, Major A, Finegold M, Kay MA, Grompe M. A universal system to select gene-modified hepatocytes in vivo. Science Translational Medicine. 8: 342ra79. PMID 27280686 DOI: 10.1126/Scitranslmed.Aad8166  0.487
2016 Valdmanis PN, Gu S, Chu K, Jin L, Zhang F, Munding EM, Zhang Y, Huang Y, Kutay H, Ghoshal K, Lisowski L, Kay MA. RNA interference-induced hepatotoxicity results from loss of the first synthesized isoform of microRNA-122 in mice. Nature Medicine. PMID 27064447 DOI: 10.1038/Nm.4079  0.409
2016 Valdmanis PN, Gu S, Chu K, Jin L, Zhang F, Munding EM, Zhang Y, Huang Y, Kutay H, Ghoshal K, Lisowski L, Kay MA. 737. RNAi Induced Hepatotoxicity Results from a Functional Depletion of the First Synthesized Isoform of miR-122 Molecular Therapy. 24: S290-S291. DOI: 10.1016/S1525-0016(16)33545-6  0.307
2016 de Alencastro G, Pekrun K, Kay M. 539. Screening for Recombinant Adeno-Associated Viral Vectors That Selectively Transduce Hepatitis B Virus Infected Cells Molecular Therapy. 24: S215. DOI: 10.1016/S1525-0016(16)33347-0  0.406
2016 Muench R, Kay M. 257. Selection of Next Generation AAV Gene Therapy Vectors for Specific and Precise Gene Delivery Molecular Therapy. 24: S101. DOI: 10.1016/S1525-0016(16)33066-0  0.447
2016 Tiffany M, Kay MA. 253. Expanded Packaging Capacity of AAV by Lumenal Charge Alteration Molecular Therapy. 24: S99-S100. DOI: 10.1016/S1525-0016(16)33062-3  0.464
2016 Spector LP, Kay MA. 129. Does Transcription Influence AAV-Mediated Homologous Recombination? Molecular Therapy. 24: S53. DOI: 10.1016/S1525-0016(16)32938-0  0.521
2016 Chandler RJ, Barzel A, Kay MA, Venditti CP. 48. Treatment of Methylmalonic Acidemia by Promoterless Gene-Targeting Using Adeno-Associated Viral (AAV) Mediated Homologous Recombination Molecular Therapy. 24: S21-S22. DOI: 10.1016/S1525-0016(16)32857-X  0.486
2015 Mellins ED, Kay MA. Viral Vectors Take On HIV Infection. The New England Journal of Medicine. 373: 770-2. PMID 26287853 DOI: 10.1056/Nejmcibr1504232  0.334
2015 Nichols TC, Whitford MH, Arruda VR, Stedman HH, Kay MA, High KA. Translational data from adeno-associated virus-mediated gene therapy of hemophilia B in dogs. Human Gene Therapy. Clinical Development. 26: 5-14. PMID 25675273 DOI: 10.1089/Humc.2014.153  0.444
2015 Diecke S, Lu J, Lee J, Termglinchan V, Kooreman NG, Burridge PW, Ebert AD, Churko JM, Sharma A, Kay MA, Wu JC. Novel codon-optimized mini-intronic plasmid for efficient, inexpensive, and xeno-free induction of pluripotency. Scientific Reports. 5: 8081. PMID 25628230 DOI: 10.1038/Srep08081  0.442
2015 Barzel A, Paulk NK, Shi Y, Huang Y, Chu K, Zhang F, Valdmanis PN, Spector LP, Porteus MH, Gaensler KM, Kay MA. Promoterless gene targeting without nucleases ameliorates haemophilia B in mice. Nature. 517: 360-4. PMID 25363772 DOI: 10.1038/Nature13864  0.476
2015 Porro F, Bortolussi G, Barzel A, Zentilin L, Vodret S, Bockor L, Kay MA, Muro AF. 688. AAV8-Mediated Liver Gene Targeting Without Nucleases Rescues Lethality in a Mouse Model of the Crigler-Najjar Syndrome Molecular Therapy. 23. DOI: 10.1016/S1525-0016(16)34297-6  0.505
2015 Nygaard S, Barzel A, Haft A, Kay MA, Grompe M. 683. In Vivo Expansion of Hepatocytes with Targeted rAAV Integration Results in a >100-Fold Increase of Transgene Expression Molecular Therapy. 23: S272. DOI: 10.1016/S1525-0016(16)34292-7  0.482
2015 de Alencastro G, Paulk NK, Pekrun K, Kay MA. 305. A Screening Strategy for Selecting Recombinant Adeno-Associated Viral Vectors That Selectively Transduce Viral Infected Cells Molecular Therapy. 23: S123. DOI: 10.1016/S1525-0016(16)33914-4  0.423
2015 Paulk NK, Charville GW, Pekrun K, Maguire K, Rando TA, Kay MA. 303. AAV Capsid Evolution for Enhanced Antibody Delivery To Human Muscle for Use in Next-Generation HIV Vaccines Molecular Therapy. 23: S122-S123. DOI: 10.1016/S1525-0016(16)33912-0  0.345
2015 Paulk NK, Pekrun K, Lisowski L, Zhang Y, Chu K, Kay MA. 262. Directed Evolution of Improved AAV Capsids for the Ideal Human Liver Vector–Can Human Liver Tropism and Human Immune Evasion Be Achieved? Molecular Therapy. 23: S104-S105. DOI: 10.1016/S1525-0016(16)33871-0  0.415
2015 Tiffany MR, Kay MA. 94. AAV Integration Site Determination Using Illumina Mate Pair Sequencing Molecular Therapy. 23: S39-S40. DOI: 10.1016/S1525-0016(16)33699-1  0.349
2014 Nichols T, Whitford MH, Arruda VR, Stedman HH, Kay MA, High KA. Translational Data from AAV-Mediated Gene Therapy of Hemophilia B in Dogs. Human Gene Therapy. Clinical Development. PMID 25548971 DOI: 10.1089/Hum.2014.153  0.413
2014 Sebastiano V, Zhen HH, Haddad B, Derafshi BH, Bashkirova E, Melo SP, Wang P, Leung TL, Siprashvili Z, Tichy A, Li J, Ameen M, Hawkins J, Lee S, Li L, ... ... Kay MA, et al. Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa. Science Translational Medicine. 6: 264ra163. PMID 25429056 DOI: 10.1126/Scitranslmed.3009540  0.352
2014 Nathwani AC, Reiss UM, Tuddenham EG, Rosales C, Chowdary P, McIntosh J, Della Peruta M, Lheriteau E, Patel N, Raj D, Riddell A, Pie J, Rangarajan S, Bevan D, Recht M, ... ... Kay MA, et al. Long-term safety and efficacy of factor IX gene therapy in hemophilia B. The New England Journal of Medicine. 371: 1994-2004. PMID 25409372 DOI: 10.1056/Nejmoa1407309  0.416
2014 Gu S, Zhang Y, Jin L, Huang Y, Zhang F, Bassik MC, Kampmann M, Kay MA. Weak base pairing in both seed and 3' regions reduces RNAi off-targets and enhances si/shRNA designs. Nucleic Acids Research. 42: 12169-76. PMID 25270879 DOI: 10.1093/Nar/Gku854  0.363
2014 Ehmer U, Zmoos AF, Auerbach RK, Vaka D, Butte AJ, Kay MA, Sage J. Organ size control is dominant over Rb family inactivation to restrict proliferation in vivo. Cell Reports. 8: 371-81. PMID 25017070 DOI: 10.1016/J.Celrep.2014.06.025  0.331
2014 Phillips N, Kay MA. Characterization of vector-based delivery of neurogenin-3 in murine diabetes. Human Gene Therapy. 25: 651-61. PMID 24635696 DOI: 10.1089/Hum.2013.206  0.311
2014 Lisowski L, Dane AP, Chu K, Zhang Y, Cunningham SC, Wilson EM, Nygaard S, Grompe M, Alexander IE, Kay MA. Selection and evaluation of clinically relevant AAV variants in a xenograft liver model. Nature. 506: 382-6. PMID 24390344 DOI: 10.1038/Nature12875  0.431
2014 Melo SP, Lisowski L, Bashkirova E, Zhen HH, Chu K, Keene DR, Marinkovich MP, Kay MA, Oro AE. Somatic correction of junctional epidermolysis bullosa by a highly recombinogenic AAV variant. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 725-33. PMID 24390279 DOI: 10.1038/Mt.2013.290  0.434
2014 Borel F, Kay MA, Mueller C. Recombinant AAV as a platform for translating the therapeutic potential of RNA interference. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 692-701. PMID 24352214 DOI: 10.1038/Mt.2013.285  0.401
2013 Valdmanis PN, Kay MA. The expanding repertoire of circular RNAs. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1112-4. PMID 23728253 DOI: 10.1038/Mt.2013.101  0.343
2013 Lu J, Zhang F, Kay MA. A mini-intronic plasmid (MIP): a novel robust transgene expression vector in vivo and in vitro. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 954-63. PMID 23459514 DOI: 10.1038/Mt.2013.33  0.502
2013 Lisowski L, Elazar M, Chu K, Glenn JS, Kay MA. The anti-genomic (negative) strand of Hepatitis C Virus is not targetable by shRNA. Nucleic Acids Research. 41: 3688-98. PMID 23396439 DOI: 10.1093/Nar/Gkt068  0.322
2013 Gracey Maniar LE, Maniar JM, Chen ZY, Lu J, Fire AZ, Kay MA. Minicircle DNA vectors achieve sustained expression reflected by active chromatin and transcriptional level. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 131-8. PMID 23183534 DOI: 10.1038/Mt.2012.244  0.457
2013 Basner-Tschakarjan E, Mingozzi F, Chen Y, Nathwani A, Tuddenham E, Riddell A, Ng C, Rustagi P, Glader B, Kay M, Reiss UM, Nienhuis AW, Davidoff A, High KA. Cellular Immune Responses To Vector In a Gene Therapy Trial For Hemophilia B Using An AAV8 Self-Complementary Factor IX Vector Blood. 122: 717-717. DOI: 10.1182/Blood.V122.21.717.717  0.35
2012 Valdmanis PN, Lisowski L, Kay MA. rAAV-mediated tumorigenesis: still unresolved after an AAV assault. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 2014-7. PMID 23131853 DOI: 10.1038/Mt.2012.220  0.419
2012 Wang Z, Lisowski L, Finegold MJ, Nakai H, Kay MA, Grompe M. AAV vectors containing rDNA homology display increased chromosomal integration and transgene persistence. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 1902-11. PMID 22990673 DOI: 10.1038/Mt.2012.157  0.492
2012 Lisowski L, Lau A, Wang Z, Zhang Y, Zhang F, Grompe M, Kay MA. Ribosomal DNA integrating rAAV-rDNA vectors allow for stable transgene expression. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 1912-23. PMID 22990671 DOI: 10.1038/Mt.2012.164  0.527
2012 Wang Y, Zhang WY, Hu S, Lan F, Lee AS, Huber B, Lisowski L, Liang P, Huang M, de Almeida PE, Won JH, Sun N, Robbins RC, Kay MA, Urnov FD, et al. Genome editing of human embryonic stem cells and induced pluripotent stem cells with zinc finger nucleases for cellular imaging. Circulation Research. 111: 1494-503. PMID 22967807 DOI: 10.1161/Circresaha.112.274969  0.382
2012 Gu S, Jin L, Huang Y, Zhang F, Kay MA. Slicing-independent RISC activation requires the argonaute PAZ domain. Current Biology : Cb. 22: 1536-42. PMID 22795694 DOI: 10.1016/J.Cub.2012.06.040  0.306
2012 Lu J, Zhang F, Xu S, Fire AZ, Kay MA. The extragenic spacer length between the 5' and 3' ends of the transgene expression cassette affects transgene silencing from plasmid-based vectors. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 2111-9. PMID 22565847 DOI: 10.1038/Mt.2012.65  0.433
2012 Valdmanis PN, Gu S, Schüermann N, Sethupathy P, Grimm D, Kay MA. Expression determinants of mammalian argonaute proteins in mediating gene silencing. Nucleic Acids Research. 40: 3704-13. PMID 22210886 DOI: 10.1093/Nar/Gkr1274  0.57
2012 Davidoff A, Tuddenham EG, Rangarajan S, Rosales C, McIntosh J, Chowdary P, Riddell A, Glader B, Rustagi P, Ng C, Kay M, Zhou J, Spence Y, Morton C, Allay J, et al. Stable Factor IX Activity Following AAV-Mediated Gene Transfer in Patients with Severe Hemophilia B Blood. 120: 752-752. DOI: 10.1182/Blood.V120.21.752.752  0.44
2011 Nathwani AC, Tuddenham EG, Rangarajan S, Rosales C, McIntosh J, Linch DC, Chowdary P, Riddell A, Pie AJ, Harrington C, O'Beirne J, Smith K, Pasi J, Glader B, Rustagi P, ... ... Kay MA, et al. Adenovirus-associated virus vector-mediated gene transfer in hemophilia B. The New England Journal of Medicine. 365: 2357-65. PMID 22149959 DOI: 10.1056/Nejmoa1108046  0.455
2011 Malato Y, Naqvi S, Schürmann N, Ng R, Wang B, Zape J, Kay MA, Grimm D, Willenbring H. Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. The Journal of Clinical Investigation. 121: 4850-60. PMID 22105172 DOI: 10.1172/Jci59261  0.58
2011 Huang M, Nguyen P, Jia F, Hu S, Gong Y, de Almeida PE, Wang L, Nag D, Kay MA, Giaccia AJ, Robbins RC, Wu JC. Double knockdown of prolyl hydroxylase and factor-inhibiting hypoxia-inducible factor with nonviral minicircle gene therapy enhances stem cell mobilization and angiogenesis after myocardial infarction. Circulation. 124: S46-54. PMID 21911818 DOI: 10.1161/Circulationaha.110.014019  0.36
2011 Deuse T, Seifert M, Phillips N, Fire A, Tyan D, Kay M, Tsao PS, Hua X, Velden J, Eiermann T, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S. Human leukocyte antigen I knockdown human embryonic stem cells induce host ignorance and achieve prolonged xenogeneic survival. Circulation. 124: S3-9. PMID 21911816 DOI: 10.1161/Circulationaha.111.020727  0.353
2011 Deuse T, Seifert M, Phillips N, Fire A, Tyan D, Kay M, Tsao PS, Hua X, Velden J, Eiermann T, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S. Immunobiology of naïve and genetically modified HLA-class-I-knockdown human embryonic stem cells. Journal of Cell Science. 124: 3029-37. PMID 21878509 DOI: 10.1242/Jcs.087718  0.316
2011 Gu S, Jin L, Zhang F, Huang Y, Grimm D, Rossi JJ, Kay MA. Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes. Proceedings of the National Academy of Sciences of the United States of America. 108: 9208-13. PMID 21576459 DOI: 10.1073/Pnas.1018023108  0.535
2011 Kay MA. State-of-the-art gene-based therapies: the road ahead. Nature Reviews. Genetics. 12: 316-28. PMID 21468099 DOI: 10.1038/Nrg2971  0.357
2011 Narsinh KH, Jia F, Robbins RC, Kay MA, Longaker MT, Wu JC. Generation of adult human induced pluripotent stem cells using nonviral minicircle DNA vectors. Nature Protocols. 6: 78-88. PMID 21212777 DOI: 10.1038/Nprot.2010.173  0.403
2011 Osborn MJ, McElmurry RT, Lees CJ, DeFeo AP, Chen ZY, Kay MA, Naldini L, Freeman G, Tolar J, Blazar BR. Minicircle DNA-based gene therapy coupled with immune modulation permits long-term expression of α-L-iduronidase in mice with mucopolysaccharidosis type I. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 450-60. PMID 21081900 DOI: 10.1038/Mt.2010.249  0.483
2011 Deuse T, Stubbendorff M, Tang-Quan K, Phillips N, Kay MA, Eiermann T, Phan TT, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S. Immunogenicity and immunomodulatory properties of umbilical cord lining mesenchymal stem cells. Cell Transplantation. 20: 655-67. PMID 21054940 DOI: 10.3727/096368910X536473  0.335
2011 Nathwani AC, Tuddenham EG, Rangarajan S, Rosales C, McIntosh JH, Linch DC, Chowdary P, Griffioen A, Riddell A, Pie J, Harrington C, O’Beirne J, Smith K, Pasi J, Glader B, ... ... Kay M, et al. Adeno-Associated Viral Vector Mediated Gene Transfer for Hemophilia B Blood. 118: 5-5. DOI: 10.1182/Blood.V118.21.5.5  0.44
2011 Deuse T, Seifert M, Fire A, Phillips N, Hua X, Velden J, Kay M, Volk H, Reichenspurner H, Robbins R, Schrepfer S. 547 Hypoimmunogeneic HLA I Knockdown Human Embryonic Stem Cells Induce Host Ignorance and Achieve Prolonged Xenogeneic Survival The Journal of Heart and Lung Transplantation. 30: S184. DOI: 10.1016/J.Healun.2011.01.558  0.312
2010 Kay MA, He CY, Chen ZY. A robust system for production of minicircle DNA vectors. Nature Biotechnology. 28: 1287-9. PMID 21102455 DOI: 10.1038/Nbt.1708  0.386
2010 Hausl MA, Zhang W, Müther N, Rauschhuber C, Franck HG, Merricks EP, Nichols TC, Kay MA, Ehrhardt A. Hyperactive sleeping beauty transposase enables persistent phenotypic correction in mice and a canine model for hemophilia B. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1896-906. PMID 20717103 DOI: 10.1038/Mt.2010.169  0.503
2010 Grimm D, Wang L, Lee JS, Schürmann N, Gu S, Börner K, Storm TA, Kay MA. Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver. The Journal of Clinical Investigation. 120: 3106-19. PMID 20697157 DOI: 10.1172/Jci43565  0.655
2010 Gracey LE, Chen ZY, Maniar JM, Valouev A, Sidow A, Kay MA, Fire AZ. An in vitro-identified high-affinity nucleosome-positioning signal is capable of transiently positioning a nucleosome in vivo. Epigenetics & Chromatin. 3: 13. PMID 20594331 DOI: 10.1186/1756-8935-3-13  0.331
2010 Nichols TC, Raymer RA, Franck HW, Merricks EP, Bellinger DA, DeFriess N, Margaritis P, Arruda VR, Kay MA, High KA. Prevention of spontaneous bleeding in dogs with haemophilia A and haemophilia B. Haemophilia : the Official Journal of the World Federation of Hemophilia. 16: 19-23. PMID 20586797 DOI: 10.1111/J.1365-2516.2010.02255.X  0.348
2010 Falcon A, Doege H, Fluitt A, Tsang B, Watson N, Kay MA, Stahl A. FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase. American Journal of Physiology. Endocrinology and Metabolism. 299: E384-93. PMID 20530735 DOI: 10.1152/Ajpendo.00226.2010  0.353
2010 Gu S, Kay MA. How do miRNAs mediate translational repression? Silence. 1: 11. PMID 20459656 DOI: 10.1186/1758-907X-1-11  0.306
2010 Haussecker D, Huang Y, Lau A, Parameswaran P, Fire AZ, Kay MA. Human tRNA-derived small RNAs in the global regulation of RNA silencing. Rna (New York, N.Y.). 16: 673-95. PMID 20181738 DOI: 10.1261/Rna.2000810  0.369
2010 Parameswaran P, Sklan E, Wilkins C, Burgon T, Samuel MA, Lu R, Ansel KM, Heissmeyer V, Einav S, Jackson W, Doukas T, Paranjape S, Polacek C, dos Santos FB, Jalili R, ... ... Kay M, et al. Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. Plos Pathogens. 6: e1000764. PMID 20169186 DOI: 10.1371/Journal.Ppat.1000764  0.544
2010 Paulk NK, Wursthorn K, Wang Z, Finegold MJ, Kay MA, Grompe M. Adeno-associated virus gene repair corrects a mouse model of hereditary tyrosinemia in vivo. Hepatology (Baltimore, Md.). 51: 1200-8. PMID 20162619 DOI: 10.1002/Hep.23481  0.465
2010 Jia F, Wilson KD, Sun N, Gupta DM, Huang M, Li Z, Panetta NJ, Chen ZY, Robbins RC, Kay MA, Longaker MT, Wu JC. A nonviral minicircle vector for deriving human iPS cells. Nature Methods. 7: 197-9. PMID 20139967 DOI: 10.1038/Nmeth.1426  0.388
2010 Haussecker D, Kay MA. miR-122 continues to blaze the trail for microRNA therapeutics. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 240-2. PMID 20125164 DOI: 10.1038/Mt.2009.313  0.335
2010 Beer S, Bellovin DI, Lee JS, Komatsubara K, Wang LS, Koh H, Börner K, Storm TA, Davis CR, Kay MA, Felsher DW, Grimm D. Low-level shRNA cytotoxicity can contribute to MYC-induced hepatocellular carcinoma in adult mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 161-70. PMID 19844192 DOI: 10.1038/Mt.2009.222  0.617
2010 Nathwani A, Tuddenham E, Rosales C, McIntosh J, Riddell A, Rustagi P, Glader B, Kay M, Allay J, Coleman J, Sleep S, High KA, Mingozzi F, Gray JT, Reiss UM, et al. Early Clinical Trial Results Following Administration of a Low Dose of a Novel Self Complementary Adeno-Associated Viral Vector Encoding Human Factor IX In Two Subjects with Severe Hemophilia B Blood. 116: 248-248. DOI: 10.1182/Blood.V116.21.248.248  0.362
2009 Cao D, Haussecker D, Huang Y, Kay MA. Combined proteomic-RNAi screen for host factors involved in human hepatitis delta virus replication. Rna (New York, N.Y.). 15: 1971-9. PMID 19776158 DOI: 10.1261/Rna.1782209  0.392
2009 Huang M, Chen Z, Hu S, Jia F, Li Z, Hoyt G, Robbins RC, Kay MA, Wu JC. Novel minicircle vector for gene therapy in murine myocardial infarction. Circulation. 120: S230-7. PMID 19752373 DOI: 10.1161/Circulationaha.108.841155  0.459
2009 Jager L, Hausl MA, Rauschhuber C, Wolf NM, Kay MA, Ehrhardt A. A rapid protocol for construction and production of high-capacity adenoviral vectors. Nature Protocols. 4: 547-64. PMID 19373227 DOI: 10.1038/Nprot.2009.4  0.415
2009 Stenler S, Andersson A, Simonson OE, Lundin KE, Chen ZY, Kay MA, Smith CI, Sylvén C, Blomberg P. Gene transfer to mouse heart and skeletal muscles using a minicircle expressing human vascular endothelial growth factor. Journal of Cardiovascular Pharmacology. 53: 18-23. PMID 19129741 DOI: 10.1097/Fjc.0B013E318194234E  0.4
2008 Zhang X, Epperly MW, Kay MA, Chen ZY, Dixon T, Franicola D, Greenberger BA, Komanduri P, Greenberger JS. Radioprotection in vitro and in vivo by minicircle plasmid carrying the human manganese superoxide dismutase transgene. Human Gene Therapy. 19: 820-6. PMID 18699723 DOI: 10.1089/Hum.2007.141  0.372
2008 Giering JC, Grimm D, Storm TA, Kay MA. Expression of shRNA from a tissue-specific pol II promoter is an effective and safe RNAi therapeutic. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 1630-6. PMID 18665161 DOI: 10.1038/Mt.2008.144  0.814
2008 Haussecker D, Cao D, Huang Y, Parameswaran P, Fire AZ, Kay MA. Capped small RNAs and MOV10 in human hepatitis delta virus replication. Nature Structural & Molecular Biology. 15: 714-21. PMID 18552826 DOI: 10.1038/Nsmb.1440  0.361
2008 Doege H, Grimm D, Falcon A, Tsang B, Storm TA, Xu H, Ortegon AM, Kazantzis M, Kay MA, Stahl A. Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia. The Journal of Biological Chemistry. 283: 22186-92. PMID 18524776 DOI: 10.1074/Jbc.M803510200  0.528
2008 Wilson JM, Gansbacher B, Berns KI, Bosch F, Kay MA, Naldini L, Wei YQ. Good news on the clinical gene transfer front. Human Gene Therapy. 19: 429-30. PMID 18507511 DOI: 10.1089/Hum.2008.0519  0.323
2008 Grimm D, Lee JS, Wang L, Desai T, Akache B, Storm TA, Kay MA. In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses. Journal of Virology. 82: 5887-911. PMID 18400866 DOI: 10.1128/Jvi.00254-08  0.638
2008 McCaffrey AP, Fawcett P, Nakai H, McCaffrey RL, Ehrhardt A, Pham TT, Pandey K, Xu H, Feuss S, Storm TA, Kay MA. The host response to adenovirus, helper-dependent adenovirus, and adeno-associated virus in mouse liver. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 931-41. PMID 18388926 DOI: 10.1038/Mt.2008.37  0.494
2008 Chen ZY, Riu E, He CY, Xu H, Kay MA. Silencing of episomal transgene expression in liver by plasmid bacterial backbone DNA is independent of CpG methylation. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 548-56. PMID 18253155 DOI: 10.1038/Sj.Mt.6300399  0.407
2008 Streetz KL, Doyonnas R, Grimm D, Jenkins DD, Fuess S, Perryman S, Lin J, Trautwein C, Shizuru J, Blau H, Sylvester KG, Kay MA. Hepatic parenchymal replacement in mice by transplanted allogeneic hepatocytes is facilitated by bone marrow transplantation and mediated by CD4 cells. Hepatology (Baltimore, Md.). 47: 706-18. PMID 18220289 DOI: 10.1002/Hep.22012  0.54
2008 Zhang X, Epperly MW, Kay MA, Chen Z, Smith T, Franicola D, Greenberger BA, Komanduri P, Greenberger JS. Radioprotection In Vitro and In Vivo by Mini Circle Plasmid Containing the Human Manganese Superoxide Dismutase (MnSOD) Transgene Human Gene Therapy. 19: 81015093227032. DOI: 10.1089/Hgt.2007.141  0.343
2007 Grimm D, Kay MA. Therapeutic application of RNAi: is mRNA targeting finally ready for prime time? The Journal of Clinical Investigation. 117: 3633-41. PMID 18060021 DOI: 10.1172/Jci34129  0.547
2007 Grimm D, Kay MA. RNAi and gene therapy: a mutual attraction. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 473-81. PMID 18024667 DOI: 10.1182/Asheducation-2007.1.473  0.644
2007 Moldt B, Yant SR, Andersen PR, Kay MA, Mikkelsen JG. Cis-acting gene regulatory activities in the terminal regions of sleeping beauty DNA transposon-based vectors. Human Gene Therapy. 18: 1193-204. PMID 17988194 DOI: 10.1089/Hum.2007.099  0.493
2007 Garrison BS, Yant SR, Mikkelsen JG, Kay MA. Postintegrative gene silencing within the Sleeping Beauty transposition system. Molecular and Cellular Biology. 27: 8824-33. PMID 17938204 DOI: 10.1128/Mcb.00498-07  0.799
2007 Kay MA. AAV vectors and tumorigenicity. Nature Biotechnology. 25: 1111-3. PMID 17921994 DOI: 10.1038/Nbt1007-1111  0.335
2007 Paskowitz DM, Greenberg KP, Yasumura D, Grimm D, Yang H, Duncan JL, Kay MA, Lavail MM, Flannery JG, Vollrath D. Rapid and stable knockdown of an endogenous gene in retinal pigment epithelium. Human Gene Therapy. 18: 871-80. PMID 17892416 DOI: 10.1089/Hum.2007.065  0.648
2007 Tward AD, Jones KD, Yant S, Cheung ST, Fan ST, Chen X, Kay MA, Wang R, Bishop JM. Distinct pathways of genomic progression to benign and malignant tumors of the liver. Proceedings of the National Academy of Sciences of the United States of America. 104: 14771-6. PMID 17785413 DOI: 10.1073/Pnas.0706578104  0.335
2007 Shen X, Storm T, Kay MA. Characterization of the relationship of AAV capsid domain swapping to liver transduction efficiency. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1955-62. PMID 17726459 DOI: 10.1038/Sj.Mt.6300293  0.473
2007 Inagaki K, Ma C, Storm TA, Kay MA, Nakai H. The role of DNA-PKcs and artemis in opening viral DNA hairpin termini in various tissues in mice. Journal of Virology. 81: 11304-21. PMID 17686847 DOI: 10.1128/Jvi.01225-07  0.345
2007 Inagaki K, Lewis SM, Wu X, Ma C, Munroe DJ, Fuess S, Storm TA, Kay MA, Nakai H. DNA palindromes with a modest arm length of greater, similar 20 base pairs are a significant target for recombinant adeno-associated virus vector integration in the liver, muscles, and heart in mice. Journal of Virology. 81: 11290-303. PMID 17686840 DOI: 10.1128/Jvi.00963-07  0.456
2007 Azuma H, Paulk N, Ranade A, Dorrell C, Al-Dhalimy M, Ellis E, Strom S, Kay MA, Finegold M, Grompe M. Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice. Nature Biotechnology. 25: 903-10. PMID 17664939 DOI: 10.1038/Nbt1326  0.387
2007 Riu E, Chen ZY, Xu H, He CY, Kay MA. Histone modifications are associated with the persistence or silencing of vector-mediated transgene expression in vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1348-55. PMID 17457320 DOI: 10.1038/Sj.Mt.6300177  0.405
2007 Zayed H, Xia L, Yerich A, Yant SR, Kay MA, Puttaraju M, McGarrity GJ, Wiest DL, McIvor RS, Tolar J, Blazar BR. Correction of DNA protein kinase deficiency by spliceosome-mediated RNA trans-splicing and sleeping beauty transposon delivery. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1273-9. PMID 17457319 DOI: 10.1038/Sj.Mt.6300178  0.407
2007 Yant SR, Huang Y, Akache B, Kay MA. Site-directed transposon integration in human cells. Nucleic Acids Research. 35: e50. PMID 17344320 DOI: 10.1093/Nar/Gkm089  0.403
2007 Grimm D, Kay MA. Combinatorial RNAi: a winning strategy for the race against evolving targets? Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 878-88. PMID 17311009 DOI: 10.1038/Sj.Mt.6300116  0.626
2007 Akache B, Grimm D, Shen X, Fuess S, Yant SR, Glazer DS, Park J, Kay MA. A two-hybrid screen identifies cathepsins B and L as uncoating factors for adeno-associated virus 2 and 8. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 330-9. PMID 17235311 DOI: 10.1038/Sj.Mt.6300053  0.702
2007 Wang AY, Ehrhardt A, Xu H, Kay MA. Adenovirus transduction is required for the correction of diabetes using Pdx-1 or Neurogenin-3 in the liver. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 255-63. PMID 17235302 DOI: 10.1038/Sj.Mt.6300032  0.615
2007 Ehrhardt A, Yant SR, Giering JC, Xu H, Engler JA, Kay MA. Somatic integration from an adenoviral hybrid vector into a hot spot in mouse liver results in persistent transgene expression levels in vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 146-56. PMID 17164786 DOI: 10.1038/Sj.Mt.6300011  0.819
2007 Tolar J, Nauta AJ, Osborn MJ, Panoskaltsis Mortari A, McElmurry RT, Bell S, Xia L, Zhou N, Riddle M, Schroeder TM, Westendorf JJ, McIvor RS, Hogendoorn PC, Szuhai K, Oseth L, ... ... Kay MA, et al. Sarcoma derived from cultured mesenchymal stem cells. Stem Cells (Dayton, Ohio). 25: 371-9. PMID 17038675 DOI: 10.1634/Stemcells.2005-0620  0.343
2007 Zhang X, Epperly MW, Kay MA, Chen Z, Smith T, Franicola D, Greenberger B, Komanduri P, Greenberger JS. Minicircle Plasmid Containing the Human Manganese Superoxide Dismutase (MnSOD) Transgene Confers Radioprotection to Hematopoietic Progenitor Cell Line 32Dcl3. Blood. 110: 5138-5138. DOI: 10.1182/Blood.V110.11.5138.5138  0.409
2007 Kay MA. MicroRNAs outwit immune limitations in gene therapy Blood. 110: 4136-4137. DOI: 10.1182/Blood-2007-09-111062  0.453
2007 Zhang X, Epperly M, Kay M, Chen Z, Smith T, Franicola D, Greenberger J. A Minicircle Plasmid Containing the Human Manganese Superoxide Dismutase (MnSOD) Transgene Confers Radioprotection to Cells InVitro International Journal of Radiation Oncology*Biology*Physics. 69: S625. DOI: 10.1016/J.Ijrobp.2007.07.1952  0.364
2006 Ehrhardt A, Engler JA, Xu H, Cherry AM, Kay MA. Molecular analysis of chromosomal rearrangements in mammalian cells after phiC31-mediated integration. Human Gene Therapy. 17: 1077-94. PMID 17069535 DOI: 10.1089/Hum.2006.17.1077  0.34
2006 Akache B, Grimm D, Pandey K, Yant SR, Xu H, Kay MA. The 37/67-kilodalton laminin receptor is a receptor for adeno-associated virus serotypes 8, 2, 3, and 9. Journal of Virology. 80: 9831-6. PMID 16973587 DOI: 10.1128/Jvi.00878-06  0.622
2006 Grimm D, Streetz KL, Jopling CL, Storm TA, Pandey K, Davis CR, Marion P, Salazar F, Kay MA. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature. 441: 537-41. PMID 16724069 DOI: 10.1038/Nature04791  0.645
2006 Inagaki K, Fuess S, Storm TA, Gibson GA, Mctiernan CF, Kay MA, Nakai H. Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8. Molecular Therapy : the Journal of the American Society of Gene Therapy. 14: 45-53. PMID 16713360 DOI: 10.1016/J.Ymthe.2006.03.014  0.467
2006 Manno CS, Pierce GF, Arruda VR, Glader B, Ragni M, Rasko JJ, Rasko J, Ozelo MC, Hoots K, Blatt P, Konkle B, Dake M, Kaye R, Razavi M, Zajko A, ... ... Kay MA, et al. Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response. Nature Medicine. 12: 342-7. PMID 16474400 DOI: 10.1038/Nm1358  0.401
2006 Grimm D, Kay MA. Therapeutic short hairpin RNA expression in the liver: viral targets and vectors. Gene Therapy. 13: 563-75. PMID 16453009 DOI: 10.1038/Sj.Gt.3302727  0.576
2006 Tolar J, O'shaughnessy MJ, Panoskaltsis-Mortari A, McElmurry RT, Bell S, Riddle M, McIvor RS, Yant SR, Kay MA, Krause D, Verfaillie CM, Blazar BR. Host factors that impact the biodistribution and persistence of multipotent adult progenitor cells. Blood. 107: 4182-8. PMID 16410448 DOI: 10.1182/Blood-2005-08-3289  0.351
2006 Grimm D, Pandey K, Nakai H, Storm TA, Kay MA. Liver transduction with recombinant adeno-associated virus is primarily restricted by capsid serotype not vector genotype. Journal of Virology. 80: 426-39. PMID 16352567 DOI: 10.1128/Jvi.80.1.426-439.2006  0.659
2006 Tolar J, Nauta AJ, Osborn MJ, Panoskaltsis-Mortari A, McElmurry RT, Bell S, Xia L, Zhou N, Riddle M, Schroeder TM, Westendorf JJ, McIvor RS, Hogendoom PC, Szuhai K, Oseth L, ... ... Kay MA, et al. Osteosarcoma Derived from Cultured Mesenchymal Stem Cells. Blood. 108: 2554-2554. DOI: 10.1182/Blood.V108.11.2554.2554  0.342
2006 Cao D, Kay MA. 852. Chromatin Study of Adenovirus Vector DNA In Vivo Molecular Therapy. 13: S329. DOI: 10.1016/J.Ymthe.2006.08.938  0.414
2006 Giering JC, Grimm D, Storm TA, Xu H, Kay MA. 796. Pol II-Driven shRNA as an Effective Hepatitis B Virus Therapeutic Molecular Therapy. 13: S308-S309. DOI: 10.1016/J.Ymthe.2006.08.885  0.799
2006 Garrison BS, Yant SR, Mikkelsen JG, Kay MA. 792. Post-Integrative Gene Silencing in the Sleeping Beauty Transposition System Molecular Therapy. 13: S307. DOI: 10.1016/J.Ymthe.2006.08.880  0.796
2006 Shen X, Xu H, Storm T, Kay MA. 746. Localization of Structural Determinants in AAV Capsid for Efficient Liver Transduction by Domain Swapping between AAV-2 and AAV-8 Molecular Therapy. 13: S288. DOI: 10.1016/J.Ymthe.2006.08.828  0.417
2006 Grimm D, Lee JS, Storm TA, Kay MA. 742. Molecular Evolution of Adeno-Associated Viral (AAV) Vectors Via DNA Family Shuffling of Primate and Non-Primate Serotypes Molecular Therapy. 13: S287. DOI: 10.1016/J.Ymthe.2006.08.824  0.656
2006 Xie L, Kang Y, Yant S, Kay M, McCray P. 680. Non-Viral Transposon Mediated Gene Transfer of Human Factor VIII to Hemophilia A Mice Molecular Therapy. 13: S262. DOI: 10.1016/J.Ymthe.2006.08.757  0.443
2006 Riu E, Chen Z, Kay MA. 539. Unraveling the Mechanisms Underlying Silencing/Activation of Episomal Vectors In Vivo Molecular Therapy. 13: S207. DOI: 10.1016/J.Ymthe.2006.08.610  0.45
2006 Chen Z, He C, Ehrhardt A, Xu H, Kay MA. 516. Development of a Minicircle Vector Free of Plasmid Bacterial DNA Sequences and Capable of øC31-Mediated Site-Specific Integration Molecular Therapy. 13: S198-S199. DOI: 10.1016/J.Ymthe.2006.08.587  0.472
2006 Hebert ML, Grimm D, Storm TA, Kay MA. 489. Treatment for Hemophilia B Using Self- Complimentary AAV8 Vectors Molecular Therapy. 13: S189-S190. DOI: 10.1016/J.Ymthe.2006.08.559  0.677
2006 Ehrhardt A, Engler JA, Xu H, Cherry A, Kay MA. 388. Chromosomal Rearrangements in Mammalian Cells Are Induced at High Frequency by the Bacteriophage Derived Integrase phiC31 Molecular Therapy. 13: S148. DOI: 10.1016/J.Ymthe.2006.08.449  0.346
2006 Haussecker D, Elazar M, Glenn JS, Kay MA. 374. Hepatitis Delta Virus-Mediated Amplification of Therapeutic RNAi Molecular Therapy. 13: S142. DOI: 10.1016/J.Ymthe.2006.08.433  0.453
2006 Inagaki K, Storm TA, Kay MA, Nakai H. 114. Revisiting rAAV Vector Integration in scid Mice: DNA-PKcs Deficiency Does Not Substantially Increase Integration Frequency in Hepatic and Non-Hepatic Tissues In Vivo Molecular Therapy. 13: S47. DOI: 10.1016/J.Ymthe.2006.08.134  0.437
2006 Shen X, Xu H, Storm T, Kay MA. 108. Study of an AAV-8 Capsid Mutant with Direct Heparin Binding Capability but Reduced Efficiency in Liver-Targeted Transduction Molecular Therapy. 13: S44-S45. DOI: 10.1016/J.Ymthe.2006.08.128  0.449
2006 Akache B, Fuess S, Grimm D, Kay MA. 103. A Screen for Host Cellular Proteins That Interact with Adeno-Associated Virus Capsid Proteins Reveals Proteins Involved in AAV8 Transduction Molecular Therapy. 13: S42-S43. DOI: 10.1016/J.Ymthe.2006.08.123  0.607
2006 Grimm D, Streetz KL, Storm TA, Jopling CL, Lee JS, Kay MA. 805. Fatality in Mice Due to Oversaturation of Cellular Micro/Short Hairpin RNA Pathways Molecular Therapy. 13. DOI: 10.1016/J.Ymthe.2006.08.1226  0.672
2006 Wursthorn K, Storm T, Kay MA, Finegold M, Grompe M. 804. In Vivo Correction of a Metabolic Liver Disease by AAV8-Mediated Homologous Recombination Molecular Therapy. 13: S311-S312. DOI: 10.1016/J.Ymthe.2006.08.1225  0.458
2006 Couto LB, Parker AE, Haniff G, Suhy DA, Kolykhalov AA, Roelvink PW, Maria Garcia L, Schroeder R, Kay MA, Cunningham SM. 1099. RNAi-Based Therapy for the Treatment of HCV Molecular Therapy. 13: S422-S423. DOI: 10.1016/J.Ymthe.2006.08.1203  0.365
2006 Grimm D, Lee JS, Streetz KL, Storm TA, Kay MA. 1066. A Novel Class of Miniature Stabilized Double-Stranded AAV (msdsAAV) Vectors for the In Vivo Expression of Short Hairpin RNAs Molecular Therapy. 13: S409. DOI: 10.1016/J.Ymthe.2006.08.1164  0.636
2006 Suhy DA, Kolykhalov AA, Couto LB, Garcia L, Schroeder AR, Parker AE, Haniff G, Kay MA, Roelvink P. 1034. Expression of Short Hairpin RNAs by Liver and Non Liver Specific RNA Pol II Expression Cassettes: What Governs Activity? Molecular Therapy. 13: S397. DOI: 10.1016/J.Ymthe.2006.08.1129  0.443
2006 Ehrhardt A, Xu H, Dillow AM, Yant SR, Nichols TC, Kay MA. 11. Transposition from a Gene-Deleted Adenoviral Vector Results in Phenotypic Correction in a Canine Model for Hemophilia B Molecular Therapy. 13: S5. DOI: 10.1016/J.Ymthe.2006.08.022  0.49
2006 Inagaki K, Fuess S, Storm TA, Kay MA, Nakai H. 9. Biology of rAAV8 in Mouse Liver Following Vector Administration at Birth Molecular Therapy. 13: S4. DOI: 10.1016/J.Ymthe.2006.08.019  0.442
2006 Inagaki K, Storm TA, Kay MA, Nakai H. 5. Mechanisms for Hairpin Loop Opening of “Closed” AAV-ITRs by Specific Cellular Endonuclease Activities, a Prerequisite for rAAV Vector Genome Recombinations In Vivo Molecular Therapy. 13: S2-S3. DOI: 10.1016/J.Ymthe.2006.08.015  0.415
2005 Ehrhardt A, Kay MA. Gutted adenovirus: a rising star on the horizon? Gene Therapy. 12: 1540-1. PMID 18360947 DOI: 10.1038/Sj.Gt.3302597  0.51
2005 Tward AD, Jones KD, Yant S, Kay MA, Wang R, Bishop JM. Genomic progression in mouse models for liver tumors. Cold Spring Harbor Symposia On Quantitative Biology. 70: 217-24. PMID 16869757 DOI: 10.1101/Sqb.2005.70.058  0.342
2005 Ohashi K, Kay MA, Yokoyama T, Kuge H, Kanehiro H, Hisanaga M, Ko S, Nakajima Y. Stability and repeat regeneration potential of the engineered liver tissues under the kidney capsule in mice. Cell Transplantation. 14: 621-7. PMID 16405072 DOI: 10.3727/000000005783982620  0.348
2005 Tolar J, Osborn M, Bell S, McElmurry R, Xia L, Riddle M, Panoskaltsis-Mortari A, Jiang Y, McIvor RS, Contag CH, Yant SR, Kay MA, Verfaillie CM, Blazar BR. Real-time in vivo imaging of stem cells following transgenesis by transposition. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 42-8. PMID 15963919 DOI: 10.1016/J.Ymthe.2005.02.023  0.377
2005 Riu E, Grimm D, Huang Z, Kay MA. Increased maintenance and persistence of transgenes by excision of expression cassettes from plasmid sequences in vivo. Human Gene Therapy. 16: 558-70. PMID 15916481 DOI: 10.1089/Hum.2005.16.558  0.661
2005 Ehrhardt A, Xu H, Huang Z, Engler JA, Kay MA. A direct comparison of two nonviral gene therapy vectors for somatic integration: in vivo evaluation of the bacteriophage integrase phiC31 and the Sleeping Beauty transposase. Molecular Therapy : the Journal of the American Society of Gene Therapy. 11: 695-706. PMID 15851008 DOI: 10.1016/J.Ymthe.2005.01.010  0.509
2005 Ohashi K, Nakai H, Couto LB, Kay MA. Modified infusion procedures affect recombinant adeno-associated virus vector type 2 transduction in the liver. Human Gene Therapy. 16: 299-306. PMID 15812225 DOI: 10.1089/Hum.2005.16.299  0.469
2005 Yant SR, Wu X, Huang Y, Garrison B, Burgess SM, Kay MA. High-resolution genome-wide mapping of transposon integration in mammals. Molecular and Cellular Biology. 25: 2085-94. PMID 15743807 DOI: 10.1128/Mcb.25.6.2085-2094.2005  0.779
2005 Nakai H, Wu X, Fuess S, Storm TA, Munroe D, Montini E, Burgess SM, Grompe M, Kay MA. Large-scale molecular characterization of adeno-associated virus vector integration in mouse liver. Journal of Virology. 79: 3606-14. PMID 15731255 DOI: 10.1128/Jvi.79.6.3606-3614.2005  0.44
2005 Chen ZY, He CY, Kay MA. Improved production and purification of minicircle DNA vector free of plasmid bacterial sequences and capable of persistent transgene expression in vivo. Human Gene Therapy. 16: 126-31. PMID 15703495 DOI: 10.1089/Hum.2005.16.126  0.46
2005 Grimm D, Pandey K, Kay MA. Adeno-associated virus vectors for short hairpin RNA expression. Methods in Enzymology. 392: 381-405. PMID 15644194 DOI: 10.1016/S0076-6879(04)92023-X  0.659
2005 Ohashi K, Waugh JM, Dake MD, Yokoyama T, Kuge H, Nakajima Y, Yamanouchi M, Naka H, Yoshioka A, Kay MA. Liver tissue engineering at extrahepatic sites in mice as a potential new therapy for genetic liver diseases. Hepatology (Baltimore, Md.). 41: 132-40. PMID 15619229 DOI: 10.1002/Hep.20484  0.361
2005 Nakai H, Fuess S, Storm TA, Muramatsu S, Nara Y, Kay MA. Unrestricted hepatocyte transduction with adeno-associated virus serotype 8 vectors in mice. Journal of Virology. 79: 214-24. PMID 15596817 DOI: 10.1128/Jvi.79.1.214-224.2005  0.461
2005 Tolar J, Osborn MJ, Panoskaltsis-Mortari A, McElmurry RT, Bell S, Xia L, Riddle M, Schroeder TM, Westendorf JJ, McIvor RS, Oseth L, Hirsch B, Yant SR, Kay MA, Peister A, et al. Mesenchymal Cancer Cells Can Arise from Ex Vivo Modified Mesenchymal Stem Cells. Blood. 106: 4326-4326. DOI: 10.1182/Blood.V106.11.4326.4326  0.346
2005 Yant SR, Huang Y, Kay MA. 1101. Fusion Proteins Consisting of the Sleeping Beauty Transposase and the Polydactyl Zinc Finger Protein E2C Direct Transposon Integration into a Unique Human Chromosomal Sequence Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.649  0.395
2005 Akache B, Glazer D, Park J, Kay MA. 1084. A Screen for Host Cellular Proteins That Interact with Adeno-Associated Virus Capsid Proteins Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.631  0.573
2005 Noll M, Bennett R, Yant S, Kay MA, Grompe M. 1046. Stable Correction of Hematopoietic Stem Cells with Non-Viral Gene Transfer Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.593  0.439
2005 Suhy DA, Couto LB, Kolykhalov AA, Parker AE, Schroeder AR, Garcia LM, Haniff G, Cunningham SM, Kay MA, Roelvink PW. 1000. In Vitro and In Vivo Evaluation of Optimized Short-Hairpin RNAs for the Treatment of the Hepatitis C Virus Using Expression Cassettes Producing One, Two or Three Anti HCV shRNAs Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.547  0.326
2005 Kolykhalov AA, Graham MW, Suhy DA, Roelvink PW, Schroeder AR, Parker AE, Garcia LM, Kay MA, Cunningham SM, Couto LB. 997. Loop Composition as Well as Orientation of the Guide Strand in shRNA May Dramatically Modulate Activity of the shRNA: Effect on the Development of RNAi-Based Inhibitors Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.544  0.344
2005 Grimm D, Pandey K, Streetz KL, Kay MA. 857. A Versatile and Efficient Viral Vector Platform for Stable In Vivo Expression of Short Hairpin RNA Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.400  0.684
2005 Ehrhardt A, Yant SR, Jeff GA, Xu H, Calos MP, Kay MA. 821. Development of a Site-Specific Integrating Gene-Deleted Adenoviral Vector for Sustained Transgene Expression Levels In Vivo Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.364  0.472
2005 Ehrhardt A, Xu H, Yant SR, Engler JA, Kay MA. 600. A Novel Gene-Deleted Adenoviral Vector for Somatic Integration and Long-Term Phenotypic Correction of Murine and Canine Hemophilia B Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.140  0.463
2005 Ohashi K, Kay MA, Yokoyama T, Kuge H, Kanehiro H, Hisanaga M, Ko S, Naka H, Yoshioka A, Nakajima Y. 597. Liver Tissue Engineering at Extra-Hepatic Site: A Novel Therapeutic Approach toward Hemophilia Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.137  0.351
2005 Garrison BS, Yant SR, Mikkelsen JG, Kay MA. 573. Investigation into the Frequency of Post-Integrative Gene Silencing Using a Non-Selective Sleeping Beauty Transposition System Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.113  0.796
2005 Riu E, Chen Z, Kay MA. 563. Differential Histone Modifications in Transcriptional Active Versus Silenced Episomal Vectors In Vivo Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.103  0.455
2005 Chen Z, He C, Xu H, Kay MA. 557. Unraveling the Molecular Mechanisms Responsible for Episomal Transgene Silencing In Vivo Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.097  0.376
2005 Inagaki K, Wu X, Fuess S, Storm TA, Kay MA, Nakai H. 516. Analysis of AAV Serotype 8 Vector Integration in Normal and DNA-PKcs-Deficient Scid Mice by a Novel Strategy Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.056  0.456
2005 Inagaki K, Storm TA, Fuess S, Kay MA, Nakai H. 504. In Vivo Characterization of AAV Serotype 9 Vectors in Mice Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.044  0.444
2005 Suhy DA, Kolykhalov AA, Couto LB, Garcia LM, Schroeder AR, Parker AE, Haniff G, Cunningham SM, Kay MA, Roelvink PW. 443. Tissue Specific Expression of Short Hairpin RNAs for the Treatment of HCV Using Liver Specific RNA Pol II Expression Cassettes Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.451  0.417
2005 Ehrhardt A, Xu H, Salazar FH, Marion PL, Kay MA. 441. Short Hairpin RNA Interference Expressed from a Gene-Deleted Adenoviral Vector Results in Reduction of Hepatits B Surface Antigen Levels In Vitro and in a Small Animal Model for Hepatitis B Infection Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.449  0.512
2005 Roelvink PW, Graham MW, Suhy DA, Couto LB, Cunningham SM, Kay MA, Rossi JJ, Kolykhalov AA. 437. Alternative Strategies To Deliver Multiple shRNAs in Order to Simultaneously Inhibit Multiple Targets Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.445  0.438
2005 Shen X, Xu H, Huang Z, Storm TA, Kay MA. 405. Comparison Study of Structural Determinants for AAV Liver Transduction by Domain Swapping between AAV-2 and AAV-8 Capsids Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.408  0.499
2005 Park J, Yant SR, Kay MA. 191. Identification of a Novel Functional Domain in the Sleeping Beauty Transposase: Towards Alleviating the Restriction of SB Overproduction Inhibition Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.194  0.531
2005 Giering JC, Kay MA. 88. Driving shRNA Transcription from PolII Promoters in Mammalian Cells Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.066  0.807
2005 Grimm D, Streetz KL, Pandey K, Storm TA, Kay MA. 87. Determinants of Toxicity Induced by In Vivo Expression of Short Hairpin RNA from AAV Vectors Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.065  0.687
2005 Mikkelsen JG, Yant SR, Ehrhardt A, Kay MA. 22. Generation of Circular Sleeping Beauty DNA Transposition Substrates by RU486-Induced Flp Recombination In Vitro |[ndash]| Steps towards a Single Integrating Adeno-Transposon Vector Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.025  0.536
2004 Yant SR, Park J, Huang Y, Mikkelsen JG, Kay MA. Mutational analysis of the N-terminal DNA-binding domain of sleeping beauty transposase: critical residues for DNA binding and hyperactivity in mammalian cells. Molecular and Cellular Biology. 24: 9239-47. PMID 15456893 DOI: 10.1128/Mcb.24.20.9239-9247.2004  0.529
2004 Jenkins DD, Streetz K, Tataria M, Sahar D, Kurobe M, Longaker MT, Kay MA, Sylvester KG. Donor-derived, liver-specific protein expression after bone marrow transplantation. Transplantation. 78: 530-6. PMID 15446311 DOI: 10.1097/01.Tp.0000130180.42573.B1  0.393
2004 Layzer JM, McCaffrey AP, Tanner AK, Huang Z, Kay MA, Sullenger BA. In vivo activity of nuclease-resistant siRNAs. Rna (New York, N.Y.). 10: 766-71. PMID 15100431 DOI: 10.1261/Rna.5239604  0.425
2004 Wang AY, Peng PD, Ehrhardt A, Storm TA, Kay MA. Comparison of adenoviral and adeno-associated viral vectors for pancreatic gene delivery in vivo. Human Gene Therapy. 15: 405-13. PMID 15053865 DOI: 10.1089/104303404322959551  0.681
2004 Chen ZY, He CY, Meuse L, Kay MA. Silencing of episomal transgene expression by plasmid bacterial DNA elements in vivo. Gene Therapy. 11: 856-64. PMID 15029228 DOI: 10.1038/Sj.Gt.3302231  0.428
2004 Thomas CE, Storm TA, Huang Z, Kay MA. Rapid uncoating of vector genomes is the key to efficient liver transduction with pseudotyped adeno-associated virus vectors. Journal of Virology. 78: 3110-22. PMID 14990730 DOI: 10.1128/Jvi.78.6.3110-3122.2004  0.439
2004 Tolar J, Bell S, McElmurry R, Xia L, McIvor RS, Yant SR, Kay MA, Contag CH, Verfaillie CM, Blazar BR. Real-Time In Vivo Biodistribution of Multipotent Adult Progenitor Cells (MAPC): Role of the Immune System in MAPC Resistance in Non-Transplanted and Bone Marrow Transplanted Mice. Blood. 104: 507-507. DOI: 10.1182/Blood.V104.11.507.507  0.325
2004 High K, Tigges M, Manno C, Sabatino D, Arruda V, Herzog R, Rustagi P, Rasko J, Sommer J, Jaworski K, Ragni M, Glader B, Lessard R, Luk A, Couto L, ... ... Kay M, et al. Human Immune Responses to AAV-2 Capsid May Limit Duration of Expression in Liver-Directed Gene Transfer in Humans with Hemophilia B. Blood. 104: 413-413. DOI: 10.1182/Blood.V104.11.413.413  0.382
2004 Tolar J, Osborn M, Bell S, Xia L, Riddle M, Panoskaltsis-Mortari A, McIvor S, Stephen YR, Kay MA, Contag CH, Verfaillie CM, Blazar BR. Transgenesis of Multipotent Adult Progenitor Cells (MAPC) with Sleeping Beauty Transposons to Determine MAPC Homing and Persistence in Real-Time In Vivo. Blood. 104: 2099-2099. DOI: 10.1182/Blood.V104.11.2099.2099  0.498
2004 Riu E, Huang Z, Kay MA. 1039. Mechanistic Insights into the Persistence of Non-Viral Mediated Gene Transfer In Vivo Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.984  0.534
2004 High K, Manno C, Sabatino D, Hutchison S, Dake M, Razavi M, Kaye R, Aruda V, Herzog R, Rustagi P, Rasko J, Hoots K, Blatt P, Sommer J, Ragni M, ... ... Kay M, et al. 1002. Immune Responses to AAV and to Factor IX in a Phase I Study of AAV-Mediated, Liver-Directed Gene Transfer for Hemophilia B Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.940  0.392
2004 Grimm D, Streetz KL, Storm TA, Nakai H, McCaffrey AP, Huang Z, Salazar FH, Marion PL, Kay MA. 371. Complete Inhibition of Hepatitis B Virus Gene Expression In Vivo with Short Hairpin RNA Expressed from a Novel Double-Stranded, Bi-Cistronic Adeno-Associated Virus Pseudotype 8 Vector Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.918  0.659
2004 Ohashi K, Yokoyama T, Kuge H, Nakajima Y, Kay MA. 876. Towards establishing a heterologous liver in rodents Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.847  0.355
2004 Noll M, Bennett R, Yant S, Mikkelsen JG, Chen C, Kay MA, Grompe M. 826. Non-Viral Gene Therapy Targeting Fanconi Anemia Hematopoietic Stem Cells: A Realistic Hope? Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.723  0.453
2004 Yant SR, Park J, Huang Y, Mikkelsen JG, Kay MA. 819. Hyperactive Transposase Mutants of the Sleeping Beauty Transposon Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.717  0.616
2004 Yant SR, Wu X, Huang Y, Daigle B, Garrison BA, Burgess SM, Kay MA. 817. Nonrandom Insertion Site Preferences for the SB Transposon In Vitro and In Vivo Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.715  0.44
2004 Garrison BS, Yant SR, Mikkelsen JG, Kay MA. 815. Investigation into the Frequency of Post-Integrative Gene Silencing Using a Non-Selective Sleeping Beauty Transposition System Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.713  0.787
2004 Ehrhardt A, Engler JA, Calos MP, Kay MA. 811. The Hotspots of Integration Targeted by the Site-Specific Integrase PhiC31 May Be Cell Line Dependent Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.709  0.41
2004 Nakai H, Storm T, Fuess S, Kay MA. 337. Unrestricted Liver Transduction with AAV Serotype 8 Vector in Mice Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.279  0.447
2004 Streetz KL, Jenkins DD, Longaker MT, Sylvester KG, Kay MA. 308. A New Model to Functionally Measure Fusion Events in the Liver After Bone-Marrow Transplantation Over Time Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.250  0.314
2004 Wang AY, Peng PD, Ehrhardt A, Storm TA, Kay MA. 172. Comparison of adenoviral and adeno-associated viral vectors for pancreatic gene delivery in vivo Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.132  0.68
2004 Park J, Yant SR, Kay MA. 148. The altered binding properties of sleeping beauty transposase hyperactive mutants may explain their enhanced efficacy Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.072  0.522
2004 Chen Z, He C, Kay MA. 141. Development of a one-step column purification of minicircle vector DNA devoid of bacterial sequences that results in high level persistent transgene expression in vivo Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.057  0.473
2004 Roelvink PW, Suhy DA, Kolykhalov AA, Cunningham SM, Mizutani T, Kay MA. 105. Optimization of Short-Hairpin RNAs for the Treatment of the Hepatitis C Virus Using AAV Vectors with Multiple Expression Cassettes Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.042  0.378
2004 Grimm D, Nakai H, Storm TA, Riu EP, Kay MA. 96. Transgene Expression from Recombinant AAV-8 Vectors in the Liver Occurs Independently of the Serotype Origin of the Viral Inverted Terminal Repeats Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.031  0.645
2004 Nakai H, Wu X, Fuess S, Storm T, Burgess S, Grompe M, Kay MA. 13. Hot Spots for rAAV2 Vector Integration in Mice Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.05.094  0.483
2004 McCaffrey AP, Pandey K, Ehrhardt A, Huang Z, Kay MA. 58. Toward Adenoviral Mediated RNA Interference for the Treatment of Hepatitis B Virus Infection|[ast]| Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.05.039  0.485
2003 Yant SR, Kay MA. Nonhomologous-end-joining factors regulate DNA repair fidelity during Sleeping Beauty element transposition in mammalian cells. Molecular and Cellular Biology. 23: 8505-18. PMID 14612396 DOI: 10.1128/Mcb.23.23.8505-8518.2003  0.306
2003 Mikkelsen JG, Yant SR, Meuse L, Huang Z, Xu H, Kay MA. Helper-Independent Sleeping Beauty transposon-transposase vectors for efficient nonviral gene delivery and persistent gene expression in vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. 8: 654-65. PMID 14529839 DOI: 10.1016/S1525-0016(03)00216-8  0.541
2003 McCaffrey A, Kay MA, Contag CH. Advancing molecular therapies through in vivo bioluminescent imaging. Molecular Imaging. 2: 75-86. PMID 12964305 DOI: 10.1162/153535003322331966  0.363
2003 Chyung YH, Peng PD, Kay MA. System for simultaneous tissue-specific and disease-specific regulation of therapeutic gene expression. Human Gene Therapy. 14: 1255-64. PMID 12952597 DOI: 10.1089/104303403767740795  0.47
2003 Chen ZY, He CY, Ehrhardt A, Kay MA. Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. 8: 495-500. PMID 12946323 DOI: 10.1016/S1525-0016(03)00168-0  0.441
2003 Park F, Ohashi K, Kay MA. The effect of age on hepatic gene transfer with self-inactivating lentiviral vectors in vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. 8: 314-23. PMID 12907154 DOI: 10.1016/S1525-0016(03)00169-2  0.442
2003 Bordier BB, Ohkanda J, Liu P, Lee SY, Salazar FH, Marion PL, Ohashi K, Meuse L, Kay MA, Casey JL, Sebti SM, Hamilton AD, Glenn JS. In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus. The Journal of Clinical Investigation. 112: 407-14. PMID 12897208 DOI: 10.1172/Jci17704  0.414
2003 McCaffrey AP, Meuse L, Karimi M, Contag CH, Kay MA. A potent and specific morpholino antisense inhibitor of hepatitis C translation in mice. Hepatology (Baltimore, Md.). 38: 503-8. PMID 12883495 DOI: 10.1053/Jhep.2003.50330  0.342
2003 Grimm D, Kay MA. From virus evolution to vector revolution: use of naturally occurring serotypes of adeno-associated virus (AAV) as novel vectors for human gene therapy. Current Gene Therapy. 3: 281-304. PMID 12871018 DOI: 10.2174/1566523034578285  0.647
2003 Nakai H, Storm TA, Fuess S, Kay MA. Pathways of removal of free DNA vector ends in normal and DNA-PKcs-deficient SCID mouse hepatocytes transduced with rAAV vectors. Human Gene Therapy. 14: 871-81. PMID 12828858 DOI: 10.1089/104303403765701169  0.374
2003 Ortiz-Urda S, Lin Q, Yant SR, Keene D, Kay MA, Khavari PA. Sustainable correction of junctional epidermolysis bullosa via transposon-mediated nonviral gene transfer. Gene Therapy. 10: 1099-104. PMID 12808440 DOI: 10.1038/Sj.Gt.3301978  0.446
2003 Ehrhardt A, Xu H, Kay MA. Episomal persistence of recombinant adenoviral vector genomes during the cell cycle in vivo. Journal of Virology. 77: 7689-95. PMID 12805471 DOI: 10.1128/Jvi.77.13.7689-7695.2003  0.485
2003 Ehrhardt A, Xu H, Dillow AM, Bellinger DA, Nichols TC, Kay MA. A gene-deleted adenoviral vector results in phenotypic correction of canine hemophilia B without liver toxicity or thrombocytopenia. Blood. 102: 2403-11. PMID 12805062 DOI: 10.1182/Blood-2003-01-0314  0.477
2003 Grimm D, Zhou S, Nakai H, Thomas CE, Storm TA, Fuess S, Matsushita T, Allen J, Surosky R, Lochrie M, Meuse L, McClelland A, Colosi P, Kay MA. Preclinical in vivo evaluation of pseudotyped adeno-associated virus vectors for liver gene therapy. Blood. 102: 2412-9. PMID 12791653 DOI: 10.1182/Blood-2003-02-0495  0.655
2003 Grimm D, Kay MA, Kleinschmidt JA. Helper virus-free, optically controllable, and two-plasmid-based production of adeno-associated virus vectors of serotypes 1 to 6. Molecular Therapy : the Journal of the American Society of Gene Therapy. 7: 839-50. PMID 12788658 DOI: 10.1016/S1525-0016(03)00095-9  0.746
2003 Nakai H, Montini E, Fuess S, Storm TA, Grompe M, Kay MA. AAV serotype 2 vectors preferentially integrate into active genes in mice. Nature Genetics. 34: 297-302. PMID 12778174 DOI: 10.1038/Ng1179  0.5
2003 McCaffrey AP, Nakai H, Pandey K, Huang Z, Salazar FH, Xu H, Wieland SF, Marion PL, Kay MA. Inhibition of hepatitis B virus in mice by RNA interference. Nature Biotechnology. 21: 639-44. PMID 12740585 DOI: 10.1038/Nbt824  0.444
2003 Thomas CE, Ehrhardt A, Kay MA. Progress and problems with the use of viral vectors for gene therapy. Nature Reviews. Genetics. 4: 346-58. PMID 12728277 DOI: 10.1038/Nrg1066  0.371
2003 Ehrhardt A, Peng PD, Xu H, Meuse L, Kay MA. Optimization of cis-acting elements for gene expression from nonviral vectors in vivo. Human Gene Therapy. 14: 215-25. PMID 12639302 DOI: 10.1089/10430340360535779  0.467
2003 Nakai H, Fuess S, Storm TA, Meuse LA, Kay MA. Free DNA ends are essential for concatemerization of synthetic double-stranded adeno-associated virus vector genomes transfected into mouse hepatocytes in vivo Molecular Therapy. 7: 112-121. PMID 12573624 DOI: 10.1016/S1525-0016(02)00034-5  0.374
2003 Nakai H, Montini E, Fuess S, Storm TA, Meuse L, Finegold M, Grompe M, Kay MA. Helper-independent and AAV-ITR-independent chromosomal integration of double-stranded linear DNA vectors in mice Molecular Therapy. 7: 101-111. PMID 12573623 DOI: 10.1016/S1525-0016(02)00023-0  0.463
2003 Sclimenti CR, Neviaser AS, Baba EJ, Meuse L, Kay MA, Calos MP. Epstein-Barr virus vectors provide prolonged robust factor IX expression in mice Biotechnology Progress. 19: 144-151. PMID 12573017 DOI: 10.1021/Bp0200907  0.555
2003 Manno CS, Chew AJ, Hutchison S, Larson PJ, Herzog RW, Arruda VR, Tai SJ, Ragni MV, Thompson A, Ozelo M, Couto LB, Leonard DG, Johnson FA, McClelland A, Scallan C, ... ... Kay MA, et al. AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe hemophilia B. Blood. 101: 2963-72. PMID 12515715 DOI: 10.1182/Blood-2002-10-3296  0.443
2003 Jenkins D, Streetz K, Kay M, Longaker M, Sylvester K. A model to quantitate cell transplant function after liver-specific injury Journal of Surgical Research. 114: 305-306. DOI: 10.1016/J.Jss.2003.08.115  0.364
2002 Montini E, Held PK, Noll M, Morcinek N, Al-Dhalimy M, Finegold M, Yant SR, Kay MA, Grompe M. In vivo correction of murine tyrosinemia type I by DNA-mediated transposition. Molecular Therapy : the Journal of the American Society of Gene Therapy. 6: 759-69. PMID 12498772 DOI: 10.1006/Mthe.2002.0812  0.503
2002 McCaffrey AP, Kay MA. A story of mice and men. Gene Therapy. 9: 1563. PMID 12424608 DOI: 10.1038/Sj.Gt.3301890  0.445
2002 Nakai H, Thomas CE, Storm TA, Fuess S, Powell S, Wright JF, Kay MA. A limited number of transducible hepatocytes restricts a wide-range linear vector dose response in recombinant adeno-associated virus-mediated liver transduction. Journal of Virology. 76: 11343-9. PMID 12388694 DOI: 10.1128/Jvi.76.22.11343-11349.2002  0.421
2002 Olivares EC, Hollis RP, Chalberg TW, Meuse L, Kay MA, Calos MP. Site-specific genomic integration produces therapeutic factor IX levels in mice Nature Biotechnology. 20: 1124-1128. PMID 12379870 DOI: 10.1038/Nbt753  0.436
2002 Yant SR, Ehrhardt A, Mikkelsen JG, Meuse L, Pham T, Kay MA. Transposition from a gutless adeno-transposon vector stabilizes transgene expression in vivo. Nature Biotechnology. 20: 999-1005. PMID 12244327 DOI: 10.1038/Nbt738  0.541
2002 Bordier BB, Marion PL, Ohashi K, Kay MA, Greenberg HB, Casey JL, Glenn JS. A prenylation inhibitor prevents production of infectious hepatitis delta virus particles. Journal of Virology. 76: 10465-72. PMID 12239323 DOI: 10.1128/Jvi.76.20.10465-10472.2002  0.323
2002 Ohashi K, Park F, Schwall RH, Kay MA. Efficient gene transduction to cultured hepatocytes by HIV-1 derived lentiviral vector Transplantation Proceedings. 34: 1431-1433. PMID 12176427 DOI: 10.1016/S0041-1345(02)02916-0  0.498
2002 McCaffrey AP, Meuse L, Pham TT, Conklin DS, Hannon GJ, Kay MA. RNA interference in adult mice. Nature. 418: 38-9. PMID 12097900 DOI: 10.1038/418038A  0.376
2002 McCaffrey AP, Ohashi K, Meuse L, Shen S, Lancaster AM, Lukavsky PJ, Sarnow P, Kay MA. Determinants of hepatitis C translational initiation in vitro, in cultured cells and mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 5: 676-84. PMID 12027551 DOI: 10.1006/Mthe.2002.0600  0.367
2002 Ehrhardt A, Kay MA. A new adenoviral helper-dependent vector results in long-term therapeutic levels of human coagulation factor IX at low doses in vivo. Blood. 99: 3923-30. PMID 12010790 DOI: 10.1182/Blood.V99.11.3923  0.457
2002 Ohashi K, Park F, Kay MA. Role of hepatocyte direct hyperplasia in lentivirus-mediated liver transduction in vivo Human Gene Therapy. 13: 653-663. PMID 11916488 DOI: 10.1089/10430340252837242  0.461
2002 Kay MA. Gene transfer for hemophilia and viral infection International Journal of Hematology. 76: 147-147. DOI: 10.1007/Bf03165228  0.474
2001 Arruda VR, Fields PA, Milner R, Wainwright L, De Miguel MP, Donovan PJ, Herzog RW, Nichols TC, Biegel JA, Razavi M, Dake M, Huff D, Flake AW, Couto L, Kay MA, et al. Lack of germline transmission of vector sequences following systemic administration of recombinant AAV-2 vector in males. Molecular Therapy : the Journal of the American Society of Gene Therapy. 4: 586-92. PMID 11735343 DOI: 10.1006/Mthe.2001.0491  0.427
2001 Mizuguchi H, Kay MA, Hayakawa T. Approaches for generating recombinant adenovirus vectors Advanced Drug Delivery Reviews. 52: 165-176. PMID 11718941 DOI: 10.1016/S0169-409X(01)00215-0  0.379
2001 Ohashi K, Park F, Kay MA. Hepatocyte transplantation: Clinical and experimental application Journal of Molecular Medicine. 79: 617-630. PMID 11715065 DOI: 10.1007/S001090100260  0.328
2001 Vollrath D, Feng W, Duncan JL, Yasumura D, D'Cruz PM, Chappelow A, Matthes MT, Kay MA, LaVail MM. Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk. Proceedings of the National Academy of Sciences of the United States of America. 98: 12584-9. PMID 11592982 DOI: 10.1073/Pnas.221364198  0.318
2001 Park F, Kay MA. Modified HIV-1 based lentiviral vectors have an effect on viral transduction efficiency and gene expression in vitro and in vivo Molecular Therapy. 4: 164-173. PMID 11545606 DOI: 10.1006/Mthe.2001.0450  0.511
2001 Stoll SM, Sclimenti CR, Baba EJ, Meuse L, Kay MA, Calos MP. Epstein-Barr virus/human vector provides high-level, long-term expression of α1-antitrypsin in mice Molecular Therapy. 4: 122-129. PMID 11482983 DOI: 10.1006/Mthe.2001.0429  0.531
2001 Nakai H, Yant SR, Storm TA, Fuess S, Meuse L, Kay MA. Extrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo Journal of Virology. 75: 6969-6976. PMID 11435577 DOI: 10.1128/Jvi.75.15.6969-6976.2001  0.484
2001 Mizuguchi H, Koizumi N, Hosono T, Utoguchi N, Watanabe Y, Kay MA, Hayakawa T. A simplified system for constructing recombinant adenoviral vectors containing heterologous peptides in the HI loop of their fiber knob Gene Therapy. 8: 730-735. PMID 11406768 DOI: 10.1038/Sj.Gt.3301453  0.361
2001 Mizuguchi H, Kay MA, Hayakawa T. In vitro ligation-based cloning of foreign DNAs into the E3 and E1 deletion regions for generation of recombinant adenovirus vectors Biotechniques. 30: 1112-1116. PMID 11355346 DOI: 10.2144/01305Dd03  0.323
2001 Chen ZY, Yant SR, He CY, Meuse L, Shen S, Kay MA. Linear DNAs concatemerize in vivo and result in sustained transgene expression in mouse liver Molecular Therapy. 3: 403-410. PMID 11273783 DOI: 10.1006/Mthe.2001.0278  0.474
2001 Ohashi K, Meuse L, Schwall R, Kay MA. cMet activation allows persistent engraftment of ectopically transplanted xenogenic human hepatocytes in mice Transplantation Proceedings. 33: 587-588. PMID 11266970 DOI: 10.1016/S0041-1345(00)02154-0  0.352
2001 Kay MA, Glorioso JC, Naldini L. Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics. Nature Medicine. 7: 33-40. PMID 11135613 DOI: 10.1038/83324  0.445
2000 Nakai H, Storm TA, Kay MA. Recruitment of single-stranded recombinant adeno-associated virus vector genomes and intermolecular recombination are responsible for stable transduction of liver in vivo Journal of Virology. 74: 9451-9463. PMID 11000214 DOI: 10.1128/Jvi.74.20.9451-9463.2000  0.437
2000 Miao CH, Ohashi K, Patijn GA, Meuse L, Ye X, Thompson AR, Kay MA. Inclusion of the hepatic locus control region, an intron, and untranslated region increases and stabilizes hepatic factor IX gene expression in vivo but not in vitro. Molecular Therapy : the Journal of the American Society of Gene Therapy. 1: 522-32. PMID 10933977 DOI: 10.1006/Mthe.2000.0075  0.499
2000 Park F, Ohashi K, Kay MA. Therapeutic levels of human factor VIII and IX using HIV-1-based lentiviral vectors in mouse liver Blood. 96: 1173-1176. PMID 10910939 DOI: 10.1182/Blood.V96.3.1173  0.447
2000 Yant SR, Meuse L, Chiu W, Ivics Z, Izsvak Z, Kay MA. Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system Nature Genetics. 25: 35-41. PMID 10802653 DOI: 10.1038/75568  0.503
2000 Nakai H, Storm TA, Kay MA. Increasing the size of rAAV-mediated expression cassettes in vivo by intermolecular joining of two complementary vectors Nature Biotechnology. 18: 527-532. PMID 10802620 DOI: 10.1038/75390  0.529
2000 Miao CH, Nakai H, Thompson AR, Storm TA, Chiu W, Snyder RO, Kay MA. Nonrandom transduction of recombinant adeno-associated virus vectors in mouse hepatocytes in vivo: cell cycling does not influence hepatocyte transduction. Journal of Virology. 74: 3793-803. PMID 10729154 DOI: 10.1128/Jvi.74.8.3793-3803.2000  0.53
2000 Ohashi K, Marion PL, Nakai H, Meuse L, Cullen JM, Bordier BB, Schwall R, Greenberg HB, Glenn JS, Kay MA. Sustained survival of human hepatocytes in mice: A model for in vivo infection with human hepatitis B and hepatitis delta viruses. Nature Medicine. 6: 327-31. PMID 10700236 DOI: 10.1038/73187  0.405
2000 Kay MA, Manno CS, Ragni MV, Larson PJ, Couto LB, McClelland A, Glader B, Chew AJ, Tai SJ, Herzog RW, Arruda V, Johnson F, Scallan C, Skarsgard E, Flake AW, et al. Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector. Nature Genetics. 24: 257-61. PMID 10700178 DOI: 10.1038/73464  0.426
2000 Lieber A, Kay MA, Li ZY. Nuclear import of moloney murine leukemia virus DNA mediated by adenovirus preterminal protein is not sufficient for efficient retroviral transduction in nondividing cells Journal of Virology. 74: 721-734. PMID 10623734 DOI: 10.1128/Jvi.74.2.721-734.2000  0.372
1999 Lieber A, Steinwaerder DS, Carlson CA, Kay MA. Integrating adenovirus-adeno-associated virus hybrid vectors devoid of all viral genes. Journal of Virology. 73: 9314-24. PMID 10516040 DOI: 10.1128/Jvi.73.11.9314-9324.1999  0.451
1999 Russell DW, Kay MA. Adeno-associated virus vectors and hematology Blood. 94: 864-874. PMID 10419876 DOI: 10.1182/Blood.V94.3.864.415K34_864_874  0.449
1999 Nakai H, Iwaki Y, Kay MA, Couto LB. Isolation of recombinant adeno-associated virus vector-cellular DNA junctions from mouse liver Journal of Virology. 73: 5438-5447. PMID 10364291 DOI: 10.1128/Jvi.73.7.5438-5447.1999  0.507
1999 Patijn GA, Kay MA. Hepatic gene therapy using adeno-associated virus vectors. Seminars in Liver Disease. 19: 61-69. PMID 10349684 DOI: 10.1055/S-2007-1007098  0.454
1999 Schowalter DB, Himeda CL, Winther BL, Wilson CB, Kay MA. Implication of interfering antibody formation and apoptosis as two different mechanisms leading to variable duration of adenovirus-mediated transgene expression in immune-competent mice Journal of Virology. 73: 4755-4766. PMID 10233936 DOI: 10.1128/Jvi.73.6.4755-4766.1999  0.344
1999 Snyder RO, Miao C, Meuse L, Tubb J, Donahue BA, Lin HF, Stafford DW, Patel S, Thompson AR, Nichols T, Read MS, Bellinger DA, Brinkhous KM, Kay MA. Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors Nature Medicine. 5: 64-70. PMID 9883841 DOI: 10.1038/4751  0.39
1999 Mizuguchi H, Kay MA. Efficient construction of a recombinant adenovirus vector by an improved in vitro ligation method. Human Gene Therapy. 9: 2577-83. PMID 9853524 DOI: 10.1089/Hum.1998.9.17-2577  0.43
1998 Lee CA, Kessler CM, Varon D, Martinowitz U, Heim M, Kay MA. Hepatic gene therapy for haemophilia B. Haemophilia. 4: 389-392. PMID 9873759 DOI: 10.1046/J.1365-2516.1998.440389.X  0.452
1998 Patijn GA, Lieber A, Schowalter DB, Schwall R, Kay MA. Hepatocyte growth factor induces hepatocyte proliferation in vivo and allows for efficient retroviral-mediated gene transfer in mice. Hepatology (Baltimore, Md.). 28: 707-16. PMID 9731563 DOI: 10.1002/Hep.510280317  0.469
1998 Wilson CB, Embree LJ, Schowalter D, Albert R, Aruffo A, Hollenbaugh D, Linsley P, Kay MA. Transient inhibition of CD28 and CD40 ligand interactions prolongs adenovirus-mediated transgene expression in the lung and facilitates expression after secondary vector administration. Journal of Virology. 72: 7542-50. PMID 9696851 DOI: 10.1128/Jvi.72.9.7542-7550.1998  0.434
1998 Patijn GA, Lieber A, Meuse L, Winther B, Kay MA. High-efficiency retrovirus-mediated gene transfer into the livers of mice. Human Gene Therapy. 9: 1449-56. PMID 9681416 DOI: 10.1089/Hum.1998.9.10-1449  0.533
1998 Miao CH, Snyder RO, Schowalter DB, Patijn GA, Donahue B, Winther B, Kay MA. The kinetics of rAAV integration in the liver. Nature Genetics. 19: 13-5. PMID 9590280 DOI: 10.1038/Ng0598-13  0.333
1998 Lieber A, He CY, Kay MA. Adenoviral preterminal protein stabilizes mini-adenoviral genomes in vitro and in vivo. Nature Biotechnology. 15: 1383-7. PMID 9415891 DOI: 10.1038/Nbt1297-1383  0.456
1998 Wilson CB, Embree LJ, Schowalter D, Albert R, Aruffo A, Hollenbaugh D, Linsley P, Kay MA. Transient Inhibition of CD28 and CD40 Ligand Interactions Prolongs Adenovirus-Mediated Transgene Expression in the Lung and Facilitates Expression after Secondary Vector Administration Journal of Virology. 72: 7542-7550. DOI: 10.1128/jvi.72.9.7542-7550.1998  0.322
1998 Lieber A, He C, Meuse L, Himeda C, Wilson C, Kay MA. Inhibition of NF-κB Activation in Combination with Bcl-2 Expression Allows for Persistence of First-Generation Adenovirus Vectors in the Mouse Liver Journal of Virology. 72: 9267-9277. DOI: 10.1128/Jvi.72.11.9267-9277.1998  0.455
1998 Patijn GA, Lieber A, Sohowalter DB, Schwall R, Terpstra OT, Kay MA. Hepatocyte growth factor (HGF) induces high level hepatocyte proliferation in vivo and allows for efficient retroviral-mediated gene transfer in mice European Journal of Gastroenterology & Hepatology. 10: A58. DOI: 10.1097/00042737-199812000-00191  0.392
1997 Barr D, Kay MA. Methods for delivery of genes to hepatocytes in vivo using recombinant adenovirus vectors. Methods in Molecular Medicine. 7: 205-212. PMID 24493428 DOI: 10.1385/0-89603-484-4:205  0.443
1997 Kay MA, Liu D, Hoogerbrugge PM. Gene therapy Proceedings of the National Academy of Sciences of the United States of America. 94: 12744-12746. PMID 9398067 DOI: 10.1073/Pnas.94.24.12744  0.364
1997 Nelson JE, Kay MA. Persistence of recombinant adenovirus in vivo is not dependent on vector DNA replication. Journal of Virology. 71: 8902-7. PMID 9343256 DOI: 10.1128/Jvi.71.11.8902-8907.1997  0.487
1997 Schowalter D, Meuse L, Wilson C, Linsley P, Kay M. Constitutive expression of murine CTLA4Ig from a recombinant adenovirus vector results in prolonged transgene expression Gene Therapy. 4: 853-860. PMID 9338015 DOI: 10.1038/Sj.Gt.3300466  0.42
1997 Schowalter DB, Kay MA. Gene Therapy: A Status Report Pediatric Annals. 26: 562-568. PMID 9302719 DOI: 10.3928/0090-4481-19970901-12  0.349
1997 Snyder RO, Miao CH, Patijn GA, Spratt SK, Danos O, Nagy D, Gown AM, Winther B, Meuse L, Cohen LK, Thompson AR, Kay MA. Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors. Nature Genetics. 16: 270-6. PMID 9207793 DOI: 10.1038/Ng0797-270  0.482
1997 Kay MA. Adenoviral Vectors for Hepatic Gene Transfer in Animals Chest. 111. PMID 9184566 DOI: 10.1378/Chest.111.6_Supplement.138S  0.429
1997 Schowalter D, Tubb J, Liu M, Wilson C, Kay M. Heterologous expression of adenovirus E3-gp19K in an E1a-deleted adenovirus vector inhibits MHC I expression in vitro, but does not prolong transgene expression in vivo Gene Therapy. 4: 351-360. PMID 9176522 DOI: 10.1038/Sj.Gt.3300398  0.372
1997 Kay MA, Meuse L, Gown AM, Linsley P, Hollenbaugh D, Aruffo A, Ochs HD, Wilson CB. Transient immunomodulation with anti-CD40 ligand antibody and CTLA4Ig enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver Proceedings of the National Academy of Sciences of the United States of America. 94: 4686-4691. PMID 9114052 DOI: 10.1073/Pnas.94.9.4686  0.463
1997 Vrancken Peeters MJ, Patijn GA, Lieber A, Perkins J, Kay MA. Expansion of donor hepatocytes after recombinant adenovirus-induced liver regeneration in mice. Hepatology (Baltimore, Md.). 25: 884-8. PMID 9096592 DOI: 10.1002/Hep.510250416  0.389
1997 Kay MA, Fausto N. Liver regeneration: prospects for therapy based on new technologies. Molecular Medicine Today. 3: 108-15. PMID 9095485 DOI: 10.1016/S1357-4310(96)10062-9  0.377
1997 Overturf K, al-Dhalimy M, Ou CN, Finegold M, Tanguay R, Lieber A, Kay M, Grompe M. Adenovirus-mediated gene therapy in a mouse model of hereditary tyrosinemia type I. Human Gene Therapy. 8: 513-21. PMID 9095403 DOI: 10.1089/Hum.1997.8.5-513  0.429
1997 Thompson AR, Kay MA. Nonviral gene transfer to the liver. Hepatology (Baltimore, Md.). 24: 1541-2. PMID 8938194 DOI: 10.1002/Hep.510240641  0.395
1997 Peeters MJ, Patijn GA, Lieber A, Meuse L, Kay MA. Adenovirus-mediated hepatic gene transfer in mice: comparison of intravascular and biliary administration. Human Gene Therapy. 7: 1693-9. PMID 8886840 DOI: 10.1089/Hum.1996.7.14-1693  0.513
1997 Lieber A, He CY, Meuse L, Schowalter D, Kirillova I, Winther B, Kay MA. The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors. Journal of Virology. 71: 8798-8807. DOI: 10.1128/Jvi.71.11.8798-8807.1997  0.49
1996 Murry CE, Kay MA, Bartosek T, Hauschka SD, Schwartz SM. Muscle differentiation during repair of myocardial necrosis in rats via gene transfer with MyoD. The Journal of Clinical Investigation. 98: 2209-17. PMID 8941636 DOI: 10.1172/Jci119030  0.341
1996 Vrancken Peeters MJ, Perkins AL, Kay MA. Method for multiple portal vein infusions in mice: quantitation of adenovirus-mediated hepatic gene transfer. Biotechniques. 20: 278-85. PMID 8825158 DOI: 10.2144/96202Rr05  0.451
1996 Grim J, Deshane J, Feng M, Lieber A, Kay M, Curiel DT. erbB-2 Knockout Employing an Intracellular Single-chain Antibody (sFv) Accomplishes Specific Toxicity in erbB-2-expressing Lung Cancer Cells American Journal of Respiratory Cell and Molecular Biology. 15: 348-354. PMID 8810638 DOI: 10.1165/Ajrcmb.15.3.8810638  0.317
1996 Lieber A, Kay MA. Adenovirus-mediated expression of ribozymes in mice. Journal of Virology. 70: 3153-3158. DOI: 10.1128/Jvi.70.5.3153-3158.1996  0.487
1996 Liu ML, Winther BL, Kay MA. Pseudotransduction of hepatocytes by using concentrated pseudotyped vesicular stomatitis virus G glycoprotein (VSV-G)-Moloney murine leukemia virus-derived retrovirus vectors: comparison of VSV-G and amphotropic vectors for hepatic gene transfer. Journal of Virology. 70: 2497-2502. DOI: 10.1128/Jvi.70.4.2497-2502.1996  0.471
1996 Lieber A, He CY, Kirillova I, Kay MA. Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo. Journal of Virology. 70: 8944-8960. DOI: 10.1128/Jvi.70.12.8944-8960.1996  0.521
1996 Lieber A, He CY, Polyak SJ, Gretch DR, Barr D, Kay MA. Elimination of hepatitis C virus RNA in infected human hepatocytes by adenovirus-mediated expression of ribozymes. Journal of Virology. 70: 8782-8791. DOI: 10.1128/Jvi.70.12.8782-8791.1996  0.366
1995 Kay MA. Hepatic gene therapy for hemophilia B. Advances in Experimental Medicine and Biology. 386: 229-234. PMID 8851032 DOI: 10.1007/978-1-4613-0331-2_22  0.458
1995 Deshane J, Siegal GP, Alvarez RD, Wang MH, Feng M, Cabrera G, Liu T, Kay M, Curiel DT. Targeted tumor killing via an intracellular antibody against erbB-2 Journal of Clinical Investigation. 96: 2980-2989. PMID 8675670 DOI: 10.1172/Jci118370  0.329
1995 Kay MA, Graham F, Leland F, Woo SL. Therapeutic serum concentrations of human alpha-1-antitrypsin after adenoviral-mediated gene transfer into mouse hepatocytes. Hepatology (Baltimore, Md.). 21: 815-9. PMID 7875680 DOI: 10.1002/Hep.1840210331  0.59
1995 Lieber A, Vrancken Peeters MJ, Kay MA. Adenovirus-mediated transfer of the amphotropic retrovirus receptor cDNA increases retroviral transduction in cultured cells. Human Gene Therapy. 6: 5-11. PMID 7703287 DOI: 10.1089/Hum.1995.6.1-5  0.44
1995 Lieber A, Vrancken Peeters MJ, Meuse L, Fausto N, Perkins J, Kay MA. Adenovirus-mediated urokinase gene transfer induces liver regeneration and allows for efficient retrovirus transduction of hepatocytes in vivo. Proceedings of the National Academy of Sciences of the United States of America. 92: 6210-4. PMID 7597103 DOI: 10.1073/Pnas.92.13.6210  0.487
1995 Wilson C, Kay MA. Immunomodulation to enhance gene therapy. Nature Medicine. 1: 887-9. PMID 7585212 DOI: 10.1038/Nm0995-887  0.358
1995 Fang B, Eisensmith RC, Wang H, Kay MA, Cross RE, Landen CN, Gordon G, Bellinger DA, Read MS, Hu PC. Gene therapy for hemophilia B: host immunosuppression prolongs the therapeutic effect of adenovirus-mediated factor IX expression. Human Gene Therapy. 6: 1039-44. PMID 7578416 DOI: 10.1089/Hum.1995.6.8-1039  0.45
1995 Lieber A, Peeters MJ, Gown A, Perkins J, Kay MA. A modified urokinase plasminogen activator induces liver regeneration without bleeding. Human Gene Therapy. 6: 1029-37. PMID 7578415 DOI: 10.1089/Hum.1995.6.8-1029  0.499
1995 Kay MA, Holterman AX, Meuse L, Gown A, Ochs HD, Linsley PS, Wilson CB. Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4Ig administration. Nature Genetics. 11: 191-7. PMID 7550348 DOI: 10.1038/Ng1095-191  0.494
1994 Kay MA. Hepatocyte transplantation for liver gene therapy. Cell Transplantation. 2: 405-6. PMID 8162281 DOI: 10.1177/096368979300200506  0.367
1994 Kay MA, Landen CN, Rothenberg SR, Taylor LA, Leland F, Wiehle S, Fang B, Bellinger D, Finegold M, Thompson AR. In vivo hepatic gene therapy: complete albeit transient correction of factor IX deficiency in hemophilia B dogs. Proceedings of the National Academy of Sciences of the United States of America. 91: 2353-7. PMID 8134398 DOI: 10.1073/Pnas.91.6.2353  0.432
1994 Kay MA, Woo SL. Gene therapy for metabolic disorders. Trends in Genetics : Tig. 10: 253-7. PMID 8091506 DOI: 10.1016/0168-9525(94)90173-2  0.562
1994 Kay MA, Woo SLC. Gene Therapy for Metabolic Diseases Ilar Journal. 36: 47-53. DOI: 10.1093/Ilar.36.3-4.47  0.308
1994 Kolodka TM, Finegold M, Kay MA, Woo SL. Hepatic gene therapy: Efficient retroviral mediated gene transfer into rat hepatocytes in vivo Somatic Cell and Molecular Genetics. 20: 251. DOI: 10.1007/BF02254765  0.547
1993 Li Q, Kay MA, Finegold M, Stratford-Perricaudet LD, Woo SL. Assessment of recombinant adenoviral vectors for hepatic gene therapy. Human Gene Therapy. 4: 403-9. PMID 8399487 DOI: 10.1089/Hum.1993.4.4-403  0.622
1993 Cristiano RJ, Smith LC, Kay MA, Brinkley BR, Woo SL. Hepatic gene therapy: efficient gene delivery and expression in primary hepatocytes utilizing a conjugated adenovirus-DNA complex. Proceedings of the National Academy of Sciences of the United States of America. 90: 11548-52. PMID 8265587 DOI: 10.1073/Pnas.90.24.11548  0.629
1993 Kay MA, Rothenberg S, Landen CN, Bellinger DA, Leland F, Toman C, Finegold M, Thompson AR, Read MS, Brinkhous KM, Woo SLC. In vivo gene therapy of hemophilia B: Sustained partial correction in factor IX-deficient dogs Science. 262: 117. PMID 8211118 DOI: 10.1126/Science.8211118  0.468
1993 Kolodka TM, Finegold M, Kay MA, Woo SL. Hepatic gene therapy: efficient retroviral-mediated gene transfer into rat hepatocytes in vivo. Somatic Cell and Molecular Genetics. 19: 491-7. PMID 7980740 DOI: 10.1007/Bf01233254  0.603
1992 Kay MA, Baley P, Rothenberg S, Leland F, Fleming L, Ponder KP, Liu TJ, Finegold M, Darlington G, Pokorny W, Woo SLC. Expression of human α1-antitrypsin in dogs after autologous transplantation of retroviral transduced hepatocytes Proceedings of the National Academy of Sciences of the United States of America. 89: 89-93. PMID 1729724 DOI: 10.1073/Pnas.89.1.89  0.41
1992 Kay MA, Ponder KP, Woo SL. Human gene therapy: present and future. Breast Cancer Research and Treatment. 21: 83-93. PMID 1627818 DOI: 10.1007/Bf01836954  0.625
1992 Kay MA, Li Q, Liu TJ, Leland F, Toman C, Finegold M, Woo SL. Hepatic gene therapy: persistent expression of human alpha 1-antitrypsin in mice after direct gene delivery in vivo. Human Gene Therapy. 3: 641-7. PMID 1482704 DOI: 10.1089/Hum.1992.3.6-641  0.652
1992 Liu TJ, Kay MA, Darlington GJ, Woo SL. Reconstitution of enzymatic activity in hepatocytes of phenylalanine hydroxylase-deficient mice. Somatic Cell and Molecular Genetics. 18: 89-96. PMID 1312261 DOI: 10.1007/Bf01233451  0.612
1988 Kay MA, Zhang JY, Jacobs-Lorena M. Identification and germline transformation of the ribosomal protein rp21 gene of Drosophila: Complementation analysis with the Minute QIII locus reveals nonidentity Mgg Molecular & General Genetics. 213: 354-358. PMID 3185506 DOI: 10.1007/Bf00339602  0.386
1987 Qian S, Zhang JY, Kay MA, Jacobs-Lorena M. Structural analysis of the Drosophila rpA1 gene, a member of the eucaryotic 'A' type ribosomal protein family Nucleic Acids Research. 15: 987-1003. PMID 3103101 DOI: 10.1093/Nar/15.3.987  0.356
1987 Kay MA, Jacobs-Lorena M. Developmental genetics of ribosome synthesis in Drosophila Trends in Genetics. 3: 347-351. DOI: 10.1016/0168-9525(87)90295-2  0.355
Low-probability matches (unlikely to be authored by this person)
2018 Winters IP, Rogers ZN, McFarland CD, Lalgudi PV, Chiou S, Kay MA, Petrov D, Winslow MM. Abstract IA03: Functional lung cancer genomics through in vivo genome editing Clinical Cancer Research. 24. DOI: 10.1158/1557-3265.Aacriaslc18-Ia03  0.3
1985 Kay MA, Jacobs-Lorena M. Selective translational regulation of ribosomal protein gene expression during early development of Drosophila melanogaster Molecular and Cellular Biology. 5: 3583-3592. PMID 3939320 DOI: 10.1128/mcb.5.12.3583-3592.1985  0.3
2016 Paulk NK, Charville G, Maguire K, Pekrun K, Zhang Y, Tiffany M, Vilches-Moure J, Lee G, Shrager J, Rando T, Kay MA. 722. AAV Capsid Evolution for Enhanced Antibody Delivery to Human Skeletal Muscle for Use in Next-Generation HIV Vaccines and Muscle Gene Therapies Molecular Therapy. 24: S284-S285. DOI: 10.1016/S1525-0016(16)33530-4  0.298
2004 Ohashi K, Yokoyama T, Kuge H, Kanehiro H, Hisanaga M, Ko S, Nagao M, Sho M, Ikeda N, Akashi S, Okayama J, Kashizuka H, Tsurui Y, Nakajima Y, Kay MA. TOWARDS ESTABLISHING A HETEROLOGOUS LIVER TISSUE USING HEPATOCYTE TRANSPLANTATION Transplantation. 78: 437-438. DOI: 10.1097/00007890-200407271-01172  0.296
2003 Kay MA, Nakai H. Looking into the safety of AAV vectors. Nature. 424: 251. PMID 12867952 DOI: 10.1038/424251B  0.294
1999 Vilain E, Merrer MLE, Lecointre C, Desangles F, Kay MA, Maroteaux P, Mccabe ERB. IMAGe, a new clinical association of Intrauterine growth retardation, Metaphyseal dysplasia, adrenal hypoplasia congenita, and Genital anomalies Journal of Clinical Endocrinology and Metabolism. 84: 4335-4340. PMID 10599684 DOI: 10.1210/Jcem.84.12.6186  0.289
2021 Liu Z, Kim HK, Xu J, Jing Y, Kay MA. The 3'tsRNAs are aminoacylated: Implications for their biogenesis. Plos Genetics. 17: e1009675. PMID 34324497 DOI: 10.1371/journal.pgen.1009675  0.289
2004 Ohashi K, Waugh JM, Dake MD, Yokoyama T, Kuge H, Nakajima Y, Kay MA. A NOVEL APPROACH FOR LIVER TISSUE ENGINEERING INTO THE SUBCUTANEOUS SPACE USING HEPATOCYTE TRANSPLANTATION Transplantation. 78: 437. DOI: 10.1097/00007890-200407271-01170  0.288
1999 Mizuguchi H, Kay MA. A simple method for constructing E1- and E1/E4-deleted recombinant adenoviral vectors Human Gene Therapy. 10: 2013-2017. PMID 10466635 DOI: 10.1089/10430349950017374  0.287
2023 Aaron KA, Pekrun K, Atkinson PJ, Billings SE, Abitbol JM, Lee IA, Eltawil Y, Chen YS, Dong W, Nelson RF, Kay MA, Cheng AG. Selection of viral capsids and promoters affects the efficacy of rescue of -deficient cochlea. Molecular Therapy. Methods & Clinical Development. 30: 413-428. PMID 37663645 DOI: 10.1016/j.omtm.2023.08.004  0.284
2014 Kay MA, Walker BD. Engineering cellular resistance to HIV. The New England Journal of Medicine. 370: 968-9. PMID 24597871 DOI: 10.1056/Nejme1400593  0.282
1999 Kay MA, High K. Gene therapy for the hemophilias Proceedings of the National Academy of Sciences of the United States of America. 96: 9973-9975. PMID 10468539 DOI: 10.1073/Pnas.96.18.9973  0.282
2021 de Alencastro G, Puzzo F, Pavel-Dinu M, Zhang F, Pillay S, Majzoub K, Tiffany M, Jang H, Sheikali A, Cromer MK, Meetei R, Carette JE, Porteus MH, Pekrun K, Kay MA. Improved Genome Editing through Inhibition of FANCM and Members of the BTR Dissolvase Complex. Molecular Therapy : the Journal of the American Society of Gene Therapy. 29: 1016-1027. PMID 33678249 DOI: 10.1016/j.ymthe.2020.10.020  0.281
2008 Kay MA. Prime time for small RNA-based therapeutics. Human Gene Therapy. 19: 15-6. PMID 18211227 DOI: 10.1089/Hum.2007.1220  0.281
2018 Paulk NK, Pekrun K, Charville GW, Maguire-Nguyen K, Wosczyna MN, Xu J, Zhang Y, Lisowski L, Yoo B, Vilches-Moure JG, Lee GK, Shrager JB, Rando TA, Kay MA. Bioengineered Viral Platform for Intramuscular Passive Vaccine Delivery to Human Skeletal Muscle. Molecular Therapy. Methods & Clinical Development. 10: 144-155. PMID 30101152 DOI: 10.1016/J.Omtm.2018.06.001  0.277
2011 Deuse T, Seifert M, Fire A, Philipps N, Hua X, Velden J, Kay M, Volk D, Reichenspurner H, Robbins R, Schrepfer S. Generation of genetically engineered low-antigenicity MHC I knock-down human embryonic stem cells to prevent immune rejection The Thoracic and Cardiovascular Surgeon. 59. DOI: 10.1055/S-0030-1269180  0.277
2010 Deuse T, Seifert M, Fire A, Phillips N, Kay M, Reichenspurner H, Robbins R, Schrepfer S. 347: Generation of Genetically Engineered Low-Antigenicity MHC I Knock-Down Human Embryonic Stem Cells To Prevent Immune Rejection The Journal of Heart and Lung Transplantation. 29: S116-S117. DOI: 10.1016/J.Healun.2009.11.360  0.277
1999 Stempien-Otero A, Karsan A, Cornejo CJ, Xiang H, Eunson T, Morrison RS, Kay M, Winn R, Harlan J. Mechanisms of hypoxia-induced endothelial cell death. Role of p53 in apoptosis. The Journal of Biological Chemistry. 274: 8039-45. PMID 10075703 DOI: 10.1074/Jbc.274.12.8039  0.277
2014 Wang Y, Liang P, Lan F, Wu H, Lisowski L, Gu M, Hu S, Kay MA, Urnov FD, Shinnawi R, Gold JD, Gepstein L, Wu JC. Genome editing of isogenic human induced pluripotent stem cells recapitulates long QT phenotype for drug testing. Journal of the American College of Cardiology. 64: 451-9. PMID 25082577 DOI: 10.1016/J.Jacc.2014.04.057  0.276
2012 Gu S, Jin L, Zhang Y, Huang Y, Zhang F, Valdmanis PN, Kay MA. The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing in vivo. Cell. 151: 900-11. PMID 23141545 DOI: 10.1016/J.Cell.2012.09.042  0.273
2015 Kay MA. Selecting the Best AAV Capsid for Human Studies. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 1800-1. PMID 26689120 DOI: 10.1038/Mt.2015.206  0.271
2022 Song R, Pekrun K, Khan TA, Zhang F, Paşca SP, Kay MA. Selection of rAAV vectors that cross the human blood-brain barrier and target the central nervous system using a transwell model. Molecular Therapy. Methods & Clinical Development. 27: 73-88. PMID 36186955 DOI: 10.1016/j.omtm.2022.09.002  0.27
2006 Manno CS, Arruda VR, Pierce GF, Glader B, Ragni M, Rasko J, Ozelo MC, Hoots K, Blatt P, Konkle B, Dake M, Kaye R, Razavi M, Zajko A, Zehnder J, ... ... Kay MA, et al. Erratum: CORRIGENDUM: Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response Nature Medicine. 12: 592-592. DOI: 10.1038/Nm0506-592B  0.269
2012 Deuse T, Seifert M, Phillips N, Fire A, Tyan D, Kay M, Tsao P, Hua X, Velden J, Eiermann T, Volk H, Reichenspurner H, Robbins R, Schrepfer S. Immunobiology of naïve and genetically-modified HLA I knockdown human embryonic stem cells The Thoracic and Cardiovascular Surgeon. 60. DOI: 10.1055/S-0031-1297531  0.268
2009 Gu S, Jin L, Zhang F, Sarnow P, Kay MA. Biological basis for restriction of microRNA targets to the 3' untranslated region in mammalian mRNAs. Nature Structural & Molecular Biology. 16: 144-50. PMID 19182800 DOI: 10.1038/Nsmb.1552  0.267
2013 Tahara H, Kay MA, Yasui W, Tahara E. MicroRNAs in Cancer: the 22nd Hiroshima Cancer Seminar/the 4th Japanese Association for RNA Interference Joint International Symposium, 30 August 2012, Grand Prince Hotel Hiroshima. Japanese Journal of Clinical Oncology. 43: 579-82. PMID 23487440 DOI: 10.1093/Jjco/Hyt037  0.263
2005 Sylvester KG, Jenkins D, Streetz K, Doyannis R, Perryman S, Kay M, Blau H. Cell therapy for hepatocyte replacement through bone marrow derived myelomonocytic progenitors Journal of the American College of Surgeons. 201: S47-S48. DOI: 10.1016/J.Jamcollsurg.2005.06.102  0.262
2020 Spector LP, Tiffany M, Ferraro NM, Abell NS, Montgomery SB, Kay MA. Evaluating the genomic parameters governing rAAV-mediated homologous recombination. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 33248247 DOI: 10.1016/j.ymthe.2020.11.025  0.26
2015 Munding EM, Kay MA. 578. microRNA Inhibition Through Gapmer Activated RNase H-Mediated Degradation Molecular Therapy. 23: S230. DOI: 10.1016/S1525-0016(16)34187-9  0.259
2020 Jackson CB, Richard AS, Ojha A, Conkright KA, Trimarchi JM, Bailey CC, Alpert MD, Kay MA, Farzan M, Choe H. AAV vectors engineered to target insulin receptor greatly enhance intramuscular gene delivery. Molecular Therapy. Methods & Clinical Development. 19: 496-506. PMID 33313337 DOI: 10.1016/j.omtm.2020.11.004  0.257
2015 Haussecker D, Kay MA. RNA interference. Drugging RNAi. Science (New York, N.Y.). 347: 1069-70. PMID 25745148 DOI: 10.1126/Science.1252967  0.254
1997 Nelson JE, Kay MA. Persistence of recombinant adenovirus in vivo is not dependent on vector DNA replication. Journal of Virology. 71: 8902-8907. DOI: 10.1128/jvi.71.11.8902-8907.1997  0.254
2014 Sebastiano V, Zhen HH, Haddad B, Bashkirova E, Melo SP, Wang P, Leung TL, Siprashvili Z, Tichy A, Li J, Ameen M, Hawkins J, Lee S, Li L, Schwertschkow A, ... ... Kay MA, et al. Erratum: Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa (Science Translational Medicine (2014) 6 (267er8)) Science Translational Medicine. 6. DOI: 10.1126/Scitranslmed.Aaa4871  0.254
2016 Chu J, Oh Y, Sens A, Ataie N, Dana H, Macklin JJ, Laviv T, Welf ES, Dean KM, Zhang F, Kim BB, Tang CT, Hu M, Baird MA, Davidson MW, ... Kay MA, et al. A bright cyan-excitable orange fluorescent protein facilitates dual-emission microscopy and enhances bioluminescence imaging in vivo. Nature Biotechnology. PMID 27240196 DOI: 10.1038/Nbt.3550  0.252
2010 Tang-Quan K, Kolk M, Deuse T, Philipp N, Kay M, Robbins R, Reichenspurner H, Schrepfer S. 128: Immunogenicity of Fetal Mesenchymal Stem Cells from the Umbilical Cord Line for Regenerative Therapies The Journal of Heart and Lung Transplantation. 29: S48-S48. DOI: 10.1016/J.Healun.2009.11.137  0.252
2005 Streetz KL, Doyonnas R, Jenkins DD, Lin S, Shizuru JA, Blau H, Sylvester K, Kay MA. 467. Allogeneic Bone-Marrow Transplantation in Mice Provides Tolerance and Promotes Massive In Vivo Selection of Subsequently Transplanted Hepatocytes Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.007  0.248
2022 Than PA, Davis CR, Rennert RC, Morrison SD, Findlay MW, Kay MA, Gurtner GC. Selective Microvascular Tissue Transfection Using Minicircle DNA for Systemic Delivery of Human Coagulation Factor IX in a Rat Model Using a Therapeutic Flap. Plastic and Reconstructive Surgery. 149: 117-129. PMID 34757962 DOI: 10.1097/PRS.0000000000008630  0.229
1999 Zen K, Karsan A, Stempien-Otero A, Yee E, Tupper J, Li X, Eunson T, Kay MA, Wilson CB, Winn RK, Harlan JM. NF-kappaB activation is required for human endothelial survival during exposure to tumor necrosis factor-alpha but not to interleukin-1beta or lipopolysaccharide. The Journal of Biological Chemistry. 274: 28808-15. PMID 10497254 DOI: 10.1074/Jbc.274.40.28808  0.227
2014 Roy-Chaudhuri B, Valdmanis PN, Zhang Y, Wang Q, Luo QJ, Kay MA. Regulation of microRNA-mediated gene silencing by microRNA precursors. Nature Structural & Molecular Biology. 21: 825-32. PMID 25086740 DOI: 10.1038/Nsmb.2862  0.226
2016 Chak K, Roy-Chaudhuri B, Kim HK, Kemp KC, Porter BE, Kay MA. Increased precursor microRNA-21 following status epilepticus can compete with mature microRNA-21 to alter translation. Experimental Neurology. PMID 27725160 DOI: 10.1016/J.Expneurol.2016.10.003  0.226
1997 Bethune C, Bui T, Liu ML, Kay MA, Ho RJ. Development of a high-performance liquid chromatographic assay for G418 sulfate (Geneticin). Antimicrobial Agents and Chemotherapy. 41: 661-664. DOI: 10.1128/Aac.41.3.661  0.216
2019 Oh Y, Park Y, Cho JH, Wu H, Paulk NK, Liu LX, Kim N, Kay MA, Wu JC, Lin MZ. An orange calcium-modulated bioluminescent indicator for non-invasive activity imaging. Nature Chemical Biology. PMID 30936501 DOI: 10.1038/S41589-019-0256-Z  0.215
2004 Ganaha F, Ohashi K, Do YS, Lee J, Sugimoto K, Minamiguchi H, Elkins CJ, Sameni D, Modanlou S, Ali M, Kao EY, Kay MA, Waugh JM, Dake MD. Efficient inhibition of in-stent restenosis by controlled stent-based inhibition of elastase: a pilot study. Journal of Vascular and Interventional Radiology : Jvir. 15: 1287-93. PMID 15525749 DOI: 10.1097/01.Rvi.0000141340.67588.4F  0.213
2015 Valdmanis PN, Roy-Chaudhuri B, Kim HK, Sayles LC, Zheng Y, Chuang CH, Caswell DR, Chu K, Zhang Y, Winslow MM, Sweet-Cordero EA, Kay MA. Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinoma. Oncogene. 34: 94-103. PMID 24317514 DOI: 10.1038/onc.2013.523  0.201
2023 Davis-Gardner ME, Weber JA, Xie J, Pekrun K, Alexander EA, Weisgrau KL, Furlott JR, Rakasz EG, Kay MA, Gao G, Farzan M, Gardner MR. A strategy for high antibody expression with low anti-drug antibodies using AAV9 vectors. Frontiers in Immunology. 14: 1105617. PMID 37153616 DOI: 10.3389/fimmu.2023.1105617  0.194
1997 Bennett RL, Karayiorgou M, Sobin CA, Norwood TH, Kay MA. Identification of an interstitial deletion in an adult female with schizophrenia, mental retardation, and dysmorphic features: further support for a putative schizophrenia-susceptibility locus at 5q21-23.1. American Journal of Human Genetics. 61: 1450-4. PMID 9399892 DOI: 10.1086/301634  0.184
1995 Jones D, Kay M, Craigen W, McCabe E, Hawkins H, Dominey A. Coal-black hyperpigmentation at birth in a child with congenital adrenal hypoplasia Journal of the American Academy of Dermatology. 33: 323-326. PMID 7615878 DOI: 10.1016/0190-9622(95)91426-9  0.184
2008 Rossi J, Zamore P, Kay MA. Wandering eye for RNAi. Nature Medicine. 14: 611. PMID 18535575 DOI: 10.1038/Nm0608-611  0.177
2005 Ohashi K, Kay MA, Kuge H, Yokoyama T, Kanehiro H, Hisanaga M, Ko S, Nagao M, Sho M, Nakajima Y. Heterotopically transplanted hepatocyte survival depends on extracellular matrix components. Transplantation Proceedings. 37: 4587-8. PMID 16387176 DOI: 10.1016/j.transproceed.2005.11.049  0.152
2006 Streetz K, Doyonnas R, Jenkins D, Perryman S, Lin S, Trautwein C, Shizuru J, Blau H, Sylvester K, Kay M. In vivo selection of liver cells in a model of allogeneic bone-marrow-transplantation Zeitschrift FüR Gastroenterologie. 44. DOI: 10.1055/s-2006-950752  0.146
2023 Holmes AD, Chan PP, Chen Q, Ivanov P, Drouard L, Polacek N, Kay MA, Lowe TM. A standardized ontology for naming tRNA-derived RNAs based on molecular origin. Nature Methods. PMID 36869120 DOI: 10.1038/s41592-023-01813-2  0.143
2021 Luo QJ, Zhang J, Li P, Wang Q, Zhang Y, Roy-Chaudhuri B, Xu J, Kay MA, Zhang QC. RNA structure probing reveals the structural basis of Dicer binding and cleavage. Nature Communications. 12: 3397. PMID 34099665 DOI: 10.1038/s41467-021-23607-w  0.141
2005 Streetz K, Elazar M, Levenberg S, Chua M, Wang D, Glenn J, So S, Ludlow J, Kay M. Evaluation of cryopreserved human hepatocytes for functional studies in vitro and in a small animal model Zeitschrift FüR Gastroenterologie. 43. DOI: 10.1055/s-2005-920012  0.132
2003 McCaffrey AP, Kay MA. RNA interference gets infectious Gene Therapy. 10: 1205. DOI: 10.1038/sj.gt.3302035  0.122
2004 Ohashi K, Kay MA. Extracellular matrix component cotransplantation prolongs survival of heterotopically transplanted human hepatocytes in mice. Transplantation Proceedings. 36: 2469-70. PMID 15561284 DOI: 10.1016/j.transproceed.2004.07.072  0.12
2006 Streetz K, Doyonnas R, Jenkins D, Perryman S, Fuess S, Lin S, Shizuru J, Blau H, Trautwein C, Sylvester K, Kay M. 75 In vivo selection of primary and bone-marrowderived hepatocytes after allogeneic transplantation in mice Journal of Hepatology. 44: S33. DOI: 10.1016/S0168-8278(06)80076-0  0.117
2004 Streetz K, Jenkins D, Longaker G, Sylvester K, Kay M. 361 Functional measurement of fusion in the liver after bone-marrow transplantation over time Journal of Hepatology. 40: 109. DOI: 10.1016/S0168-8278(04)90361-3  0.117
2008 Lazarus JJ, Kay MA, McCarter AL, Wooten RM. Viable Borrelia burgdorferi enhances interleukin-10 production and suppresses activation of murine macrophages. Infection and Immunity. 76: 1153-62. PMID 18086805 DOI: 10.1128/IAI.01404-07  0.099
2019 Premaratne S, Hopkins J, Duddy M, Sang KT, Kay M, Rogoveanu R, Nicholl P, Tiwari A. Abdominal Aortic Aneurysm Repair in Renal and Liver Transplant Recipients. Vascular and Endovascular Surgery. 1538574419880673. PMID 31601161 DOI: 10.1177/1538574419880673  0.078
2019 Premaratne S, Hopkins J, Duddy M, Sang KT, Kay M, Rogoveanu R, Nicholl P, Tiwari A. Abdominal Aortic Aneurysm Repair in Renal and Liver Transplant Recipients European Journal of Vascular and Endovascular Surgery. 58: e848-e850. DOI: 10.1016/j.ejvs.2019.09.468  0.078
2017 Al Shakarchi J, Kay M, Kuyumdzhiev S, Psarros V, Rogoveanu R, Vohra R. Effect of tumescent anesthesia and patient positioning on laser tip junctional distance during endovenous laser ablation. Journal of Vascular Surgery. Venous and Lymphatic Disorders. PMID 29097173 DOI: 10.1016/j.jvsv.2017.08.013  0.05
2021 Mehanna H, Mistry P, Golusinski P, Maio PD, Nankivell P, Snider F, Ferrante AMR, Montalto N, Nicolai P, Marcantoni A, Grandi C, Zavatta M, Grego F, Malec K, Hosal S, ... ... Kay M, et al. Development and validation of an improved classification and risk stratification system for carotid body tumors: A multinational collaborative cohort study. Head & Neck. PMID 34418219 DOI: 10.1002/hed.26844  0.049
2016 Mak JK, Kay M. Carotid body tumour associated with cyanotic heart disease. Bmj Case Reports. 2016. PMID 26961564 DOI: 10.1136/bcr-2016-214728  0.042
2017 Vitalis A, Shantsila A, Vohra RK, Kay M, Bennett PC, Lip GYH, Gill PS. Peripheral arterial disease amongst British ethnic minorities in a community based population: The Ethnic-Echocardiographic Heart of England Screening Study (E-ECHOES). International Journal of Clinical Practice. 71. PMID 28741813 DOI: 10.1111/ijcp.12977  0.041
2014 Sharples A, Kay M, Sykes T, Fox A, Houghton A. Multilevel bypass grafting: is it worth it? Annals of Vascular Surgery. 28: 1697-702. PMID 24704851 DOI: 10.1016/j.avsg.2014.03.027  0.04
2004 Turner BL, Kay MA, Westermann DT. Colloidal phosphorus in surface runoff and water extracts from semiarid soils of the western United States. Journal of Environmental Quality. 33: 1464-72. PMID 15254129  0.039
2005 Samarsky D, Taylor M, Kay MA, McCaffrey AP. RNAi in drug development: Practical considerations Rna Interference Technology: From Basic Science to Drug Development. 384-395. DOI: 10.1017/CBO9780511546402.030  0.039
2017 Vitalis A, Lip GY, Kay M, Vohra RK, Shantsila A. Ethnic differences in the prevalence of peripheral arterial disease: a systematic review and meta-analysis. Expert Review of Cardiovascular Therapy. PMID 28290228 DOI: 10.1080/14779072.2017.1305890  0.037
2013 Beehler GP, Rodrigues AE, Kay MA, Kiviniemi MT, Steinbrenner L. Lasting impact: understanding the psychosocial implications of cancer among military veterans. Journal of Psychosocial Oncology. 31: 430-50. PMID 23844923 DOI: 10.1080/07347332.2013.798762  0.036
2022 Vitalis A, Shantsila A, Kay M, Vohra RK, Lip GYH. Outcome of Femoral Angioplasty/Stenting Procedures in Different Ethnic Groups in England: A Retrospective Analysis of Hospital Episode Statistics and Review of Literature. Journal of Endovascular Therapy : An Official Journal of the International Society of Endovascular Specialists. 15266028211070967. PMID 35023390 DOI: 10.1177/15266028211070967  0.032
2014 Sharples A, Kay M, Sykes T, Fox A, Houghton A. Vein graft aneurysms following popliteal aneurysm repair are more common than we think. Vascular. PMID 25331071 DOI: 10.1177/1708538114557070  0.029
2014 Beehler GP, Rodrigues AE, Kay MA, Kiviniemi MT, Steinbrenner L. Perceptions of barriers and facilitators to health behavior change among veteran cancer survivors. Military Medicine. 179: 998-1005. PMID 25181718 DOI: 10.7205/Milmed-D-14-00027  0.029
2021 Vitalis A, Shantsila A, Kay M, Vohra RK, Lip GYH. Outcome of femoral-popliteal bypass procedures in different ethnic groups in England: A retrospective analysis of Hospital Episode Statistics. Annals of Vascular Surgery. PMID 33951529 DOI: 10.1016/j.avsg.2021.04.018  0.028
1973 Kay MA, Gray DH, Vogt JR. Determination of aluminum in technetium-99m generator eluants by neutron activation analysis Analytical Chemistry. 45: 2261-2262. DOI: 10.1021/ac60335a042  0.028
1981 Riggs CA, Kay MA, Troutner DE. 123mTe as a calibration standard for123I Journal of Radioanalytical Chemistry. 62: 285-290. DOI: 10.1007/BF02517358  0.028
2021 Vitalis A, Nirantharakumar K, Thayakaran R, Vohra RK, Kay M, Shantsila A, Lip GYH. The Impact of Atrial Fibrillation on Outcomes of Peripheral Arterial Disease: Analysis of Routinely Collected Primary Care Data. The American Journal of Medicine. PMID 34793748 DOI: 10.1016/j.amjmed.2021.10.021  0.026
2017 Cragg J, Lowry D, Hopkins J, Parker D, Kay M, Duddy M, Tiwari A. Safety and Outcomes of Ipsilateral Antegrade Angioplasty for Femoropopliteal Disease. Vascular and Endovascular Surgery. 1538574417739762. PMID 29237359 DOI: 10.1177/1538574417739762  0.025
2015 Kay M, Rogoveanu R, Hodson J, Tallowin S, Hopkins J, Duddy M, Vohra R. Factors Affecting the Results of Superficial Femoral Artery Stenting. Vascular and Endovascular Surgery. PMID 26584581 DOI: 10.1177/1538574415614405  0.025
2023 Elsabbagh MA, Kay M, Tiwari A. PAEDIATRIC VASCULAR SURGERY: A review of cases from a dedicated paediatric vascular surgery clinic. Annals of Vascular Surgery. PMID 37940085 DOI: 10.1016/j.avsg.2023.09.083  0.023
1994 Westermann DT, Bosma SM, Kay MA. Nutrient concentration relationships between the fourth petiole and upper-stem of potato plants American Potato Journal. 71: 817-828. DOI: 10.1007/BF02849377  0.021
2020 Vitalis A, Shantsila A, Proietti M, Vohra RK, Kay M, Olshansky B, Lip GYH. Peripheral arterial disease in patients with atrial fibrillation: The Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) study. The American Journal of Medicine. PMID 32956630 DOI: 10.1016/j.amjmed.2020.08.026  0.021
2004 Turner BL, Kay MA, Westermann DT. Phosphorus in surface runoff from calcareous arable soils of the semiarid Western United States. Journal of Environmental Quality. 33: 1814-21. PMID 15356242  0.02
2016 Disterer P, Kay MA, Parker GC. Dieter C. Gruenert, PhD (1949-2016). Nucleic Acid Therapeutics. 26: 266-7. PMID 27500925 DOI: 10.1089/nat.2016.29002.par  0.01
2016 Srivastava A, Kay MA, Athanasopoulos T, Angastiniotis M, Anagnostopoulos A, Karponi G, Yannaki E, Zon LI, Lederer CW, Phylactides MS, Kleanthous M. A Tribute to George Stamatoyannopoulos. Human Gene Therapy. 27: 280-6. PMID 27074151 DOI: 10.1089/hum.2016.29025.gst  0.01
2011 Nicassio PM, Kay MA, Custodio MK, Irwin MR, Olmstead R, Weisman MH. An evaluation of a biopsychosocial framework for health-related quality of life and disability in rheumatoid arthritis. Journal of Psychosomatic Research. 71: 79-85. PMID 21767687 DOI: 10.1016/J.Jpsychores.2011.01.008  0.01
2006 Kay MA, Main IG, Elphick SC, Ngwenya BT. Fault gouge diagenesis at shallow burial depth: Solution-precipitation reactions in well-sorted and poorly sorted powders of crushed sandstone Earth and Planetary Science Letters. 243: 607-614. DOI: 10.1016/j.epsl.2006.01.017  0.01
2001 Kay MA. Anthropologist of domestic care Western Journal of Nursing Research. 23: 783-794. PMID 11728028 DOI: 10.1177/01939450122045618  0.01
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