Robert M. Kotin, PhD - Publications

National Institutes of Health, Bethesda, MD 

74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2013 Li L, Dimitriadis EK, Yang Y, Li J, Yuan Z, Qiao C, Beley C, Smith RH, Garcia L, Kotin RM. Production and characterization of novel recombinant adeno-associated virus replicative-form genomes: a eukaryotic source of DNA for gene transfer. Plos One. 8: e69879. PMID 23936358 DOI: 10.1371/journal.pone.0069879  0.72
2013 Airenne KJ, Hu YC, Kost TA, Smith RH, Kotin RM, Ono C, Matsuura Y, Wang S, Ylä-Herttuala S. Baculovirus: an insect-derived vector for diverse gene transfer applications. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 739-49. PMID 23439502 DOI: 10.1038/mt.2012.286  0.72
2013 Barbash IM, Cecchini S, Faranesh AZ, Virag T, Li L, Yang Y, Hoyt RF, Kornegay JN, Bogan JR, Garcia L, Lederman RJ, Kotin RM. MRI roadmap-guided transendocardial delivery of exon-skipping recombinant adeno-associated virus restores dystrophin expression in a canine model of Duchenne muscular dystrophy. Gene Therapy. 20: 274-82. PMID 22551778 DOI: 10.1038/gt.2012.38  0.72
2012 Denard J, Beley C, Kotin R, Lai-Kuen R, Blot S, Leh H, Asokan A, Samulski RJ, Moullier P, Voit T, Garcia L, Svinartchouk F. Human galectin 3 binding protein interacts with recombinant adeno-associated virus type 6. Journal of Virology. 86: 6620-31. PMID 22496229 DOI: 10.1128/JVI.00297-12  0.72
2011 Kotin RM. Large-scale recombinant adeno-associated virus production. Human Molecular Genetics. 20: R2-6. PMID 21531790 DOI: 10.1093/hmg/ddr141  0.72
2011 Cecchini S, Virag T, Kotin RM. Reproducible high yields of recombinant adeno-associated virus produced using invertebrate cells in 0.02- to 200-liter cultures. Human Gene Therapy. 22: 1021-30. PMID 21381980 DOI: 10.1089/hum.2010.250  0.72
2009 Virag T, Cecchini S, Kotin RM. Producing recombinant adeno-associated virus in foster cells: overcoming production limitations using a baculovirus-insect cell expression strategy. Human Gene Therapy. 20: 807-17. PMID 19604040 DOI: 10.1089/hum.2009.092  0.72
2009 Smith RH, Levy JR, Kotin RM. A simplified baculovirus-AAV expression vector system coupled with one-step affinity purification yields high-titer rAAV stocks from insect cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 1888-96. PMID 19532142 DOI: 10.1038/mt.2009.128  0.72
2009 Cecchini S, Negrete A, Virag T, Graham BS, Cohen JI, Kotin RM. Evidence of prior exposure to human bocavirus as determined by a retrospective serological study of 404 serum samples from adults in the United States. Clinical and Vaccine Immunology : Cvi. 16: 597-604. PMID 19244471 DOI: 10.1128/CVI.00470-08  0.72
2008 Negrete A, Kotin RM. Large-scale production of recombinant adeno-associated viral vectors. Methods in Molecular Biology (Clifton, N.J.). 433: 79-96. PMID 18679618 DOI: 10.1007/978-1-59745-237-3_5  0.72
2008 Negrete A, Kotin RM. Strategies for manufacturing recombinant adeno-associated virus vectors for gene therapy applications exploiting baculovirus technology. Briefings in Functional Genomics & Proteomics. 7: 303-11. PMID 18632744 DOI: 10.1093/bfgp/eln034  0.72
2008 Smith RH, Yang L, Kotin RM. Chromatography-based purification of adeno-associated virus. Methods in Molecular Biology (Clifton, N.J.). 434: 37-54. PMID 18470638 DOI: 10.1007/978-1-60327-248-3_4  0.72
2008 Cecchini S, Negrete A, Kotin RM. Toward exascale production of recombinant adeno-associated virus for gene transfer applications. Gene Therapy. 15: 823-30. PMID 18401433 DOI: 10.1038/gt.2008.61  0.72
2008 Hsu PY, Kotin RM, Yang YW. Glucose- and metabolically regulated hepatic insulin gene therapy for diabetes. Pharmaceutical Research. 25: 1460-8. PMID 18293064 DOI: 10.1007/s11095-008-9539-x  0.72
2007 Szerlip NJ, Walbridge S, Yang L, Morrison PF, Degen JW, Jarrell ST, Kouri J, Kerr PB, Kotin R, Oldfield EH, Lonser RR. Real-time imaging of convection-enhanced delivery of viruses and virus-sized particles. Journal of Neurosurgery. 107: 560-7. PMID 17886556 DOI: 10.3171/JNS-07/09/0560  0.72
2007 Negrete A, Yang LC, Mendez AF, Levy JR, Kotin RM. Economized large-scale production of high yield of rAAV for gene therapy applications exploiting baculovirus expression system. The Journal of Gene Medicine. 9: 938-48. PMID 17764098 DOI: 10.1002/jgm.1092  0.72
2007 Negrete A, Esteban G, Kotin RM. Process optimization of large-scale production of recombinant adeno-associated vectors using dielectric spectroscopy. Applied Microbiology and Biotechnology. 76: 761-72. PMID 17680241 DOI: 10.1007/s00253-007-1030-9  0.72
2007 Negrete A, Kotin RM. Production of recombinant adeno-associated vectors using two bioreactor configurations at different scales. Journal of Virological Methods. 145: 155-61. PMID 17606302 DOI: 10.1016/j.jviromet.2007.05.020  0.72
2007 Schirmer JM, Miyagi N, Rao VP, Ricci D, Federspiel MJ, Kotin RM, Russell SJ, McGregor CG. Recombinant adeno-associated virus vector for gene transfer to the transplanted rat heart. Transplant International : Official Journal of the European Society For Organ Transplantation. 20: 550-7. PMID 17403107 DOI: 10.1111/j.1432-2277.2007.00479.x  0.72
2007 Li L, Yang L, Scudiero DA, Miller SA, Yu ZX, Stukenberg PT, Shoemaker RH, Kotin RM. Development of recombinant adeno-associated virus vectors carrying small interfering RNA (shHec1)-mediated depletion of kinetochore Hec1 protein in tumor cells. Gene Therapy. 14: 814-27. PMID 17330085 DOI: 10.1038/  0.72
2006 Thorsen F, Afione S, Huszthy PC, Tysnes BB, Svendsen A, Bjerkvig R, Kotin RM, Lønning PE, Hoover F. Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human glioma. The Journal of Gene Medicine. 8: 1131-40. PMID 16810631 DOI: 10.1002/jgm.939  0.72
2006 Urabe M, Nakakura T, Xin KQ, Obara Y, Mizukami H, Kume A, Kotin RM, Ozawa K. Scalable generation of high-titer recombinant adeno-associated virus type 5 in insect cells. Journal of Virology. 80: 1874-85. PMID 16439543 DOI: 10.1128/JVI.80.4.1874-1885.2006  0.72
2005 Li W, Yu ZX, Kotin RM. Profiles of PrKX expression in developmental mouse embryo and human tissues. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 53: 1003-9. PMID 15879576 DOI: 10.1369/jhc.4A6568.2005  0.72
2005 Huszthy PC, Svendsen A, Wilson JM, Kotin RM, Lønning PE, Bjerkvig R, Hoover F. Widespread dispersion of adeno-associated virus serotype 1 and adeno-associated virus serotype 6 vectors in the rat central nervous system and in human glioblastoma multiforme xenografts. Human Gene Therapy. 16: 381-92. PMID 15812233 DOI: 10.1089/hum.2005.16.381  0.72
2005 Harper SQ, Staber PD, He X, Eliason SL, Martins IH, Mao Q, Yang L, Kotin RM, Paulson HL, Davidson BL. RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model. Proceedings of the National Academy of Sciences of the United States of America. 102: 5820-5. PMID 15811941 DOI: 10.1073/pnas.0501507102  0.72
2005 Li L, Yang L, Kotin RM. The DNA minor groove binding agents Hoechst 33258 and 33342 enhance recombinant adeno-associated virus (rAAV) transgene expression. The Journal of Gene Medicine. 7: 420-31. PMID 15538728 DOI: 10.1002/jgm.681  0.72
2004 Xia H, Mao Q, Eliason SL, Harper SQ, Martins IH, Orr HT, Paulson HL, Yang L, Kotin RM, Davidson BL. RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia. Nature Medicine. 10: 816-20. PMID 15235598 DOI: 10.1038/nm1076  0.72
2004 Hickman AB, Ronning DR, Perez ZN, Kotin RM, Dyda F. The nuclease domain of adeno-associated virus rep coordinates replication initiation using two distinct DNA recognition interfaces. Molecular Cell. 13: 403-14. PMID 14967147 DOI: 10.1016/S1097-2765(04)00023-1  0.72
2003 Lotery AJ, Yang GS, Mullins RF, Russell SR, Schmidt M, Stone EM, Lindbloom JD, Chiorini JA, Kotin RM, Davidson BL. Adeno-associated virus type 5: transduction efficiency and cell-type specificity in the primate retina. Human Gene Therapy. 14: 1663-71. PMID 14633408 DOI: 10.1089/104303403322542301  0.72
2003 Smith RH, Ding C, Kotin RM. Serum-free production and column purification of adeno-associated virus type 5. Journal of Virological Methods. 114: 115-24. PMID 14625046 DOI: 10.1016/j.jviromet.2003.09.002  0.72
2002 Urabe M, Ding C, Kotin RM. Insect cells as a factory to produce adeno-associated virus type 2 vectors. Human Gene Therapy. 13: 1935-43. PMID 12427305 DOI: 10.1089/10430340260355347  0.72
2002 Hickman AB, Ronning DR, Kotin RM, Dyda F. Structural unity among viral origin binding proteins: crystal structure of the nuclease domain of adeno-associated virus Rep. Molecular Cell. 10: 327-37. PMID 12191478 DOI: 10.1016/S1097-2765(02)00592-0  0.72
2002 Smith RH, Afione SA, Kotin RM. Transposase-mediated construction of an integrated adeno-associated virus type 5 helper plasmid. Biotechniques. 33: 204-6, 208, 210-1. PMID 12139247  0.72
2002 Mastakov MY, Baer K, Symes CW, Leichtlein CB, Kotin RM, During MJ. Immunological aspects of recombinant adeno-associated virus delivery to the mammalian brain. Journal of Virology. 76: 8446-54. PMID 12134047 DOI: 10.1128/JVI.76.16.8446-8454.2002  0.72
2002 Yang GS, Schmidt M, Yan Z, Lindbloom JD, Harding TC, Donahue BA, Engelhardt JF, Kotin R, Davidson BL. Virus-mediated transduction of murine retina with adeno-associated virus: effects of viral capsid and genome size. Journal of Virology. 76: 7651-60. PMID 12097579 DOI: 10.1128/JVI.76.15.7651-7660.2002  0.72
2002 Mastakov MY, Baer K, Kotin RM, During MJ. Recombinant adeno-associated virus serotypes 2- and 5-mediated gene transfer in the mammalian brain: quantitative analysis of heparin co-infusion. Molecular Therapy : the Journal of the American Society of Gene Therapy. 5: 371-80. PMID 11945063 DOI: 10.1006/mthe.2002.0564  0.72
2002 Yamano S, Huang LY, Ding C, Chiorini JA, Goldsmith CM, Wellner RB, Golding B, Kotin RM, Scott DE, Baum BJ. Recombinant adeno-associated virus serotype 2 vectors mediate stable interleukin 10 secretion from salivary glands into the bloodstream. Human Gene Therapy. 13: 287-98. PMID 11812284 DOI: 10.1089/10430340252769806  0.72
2002 Schmidt M, Chiorini JA, Afione S, Kotin R. Adeno-associated virus type 2 Rep78 inhibition of PKA and PRKX: Fine mapping and analysis of mechanism Journal of Virology. 76: 1033-1042. PMID 11773379  0.72
2002 Ding C, Urabe M, Bergoin M, Kotin RM. Biochemical characterization of Junonia coenia densovirus nonstructural protein NS-1. Journal of Virology. 76: 338-45. PMID 11739698 DOI: 10.1128/JVI.76.1.338-345.2002  0.72
2002 Afione S, Kotin RM. Gene transfer on target Chemistry and Industry (London). 16-18.  0.72
2000 Yang YW, Kotin RM. Glucose-responsive gene delivery in pancreatic Islet cells via recombinant adeno-associated viral vectors. Pharmaceutical Research. 17: 1056-61. PMID 11087036  0.72
2000 Schmidt M, Afione S, Kotin RM. Adeno-associated virus type 2 Rep78 induces apoptosis through caspase activation independently of p53. Journal of Virology. 74: 9441-50. PMID 11000213 DOI: 10.1128/JVI.74.20.9441-9450.2000  0.72
2000 Zabner J, Seiler M, Walters R, Kotin RM, Fulgeras W, Davidson BL, Chiorini JA. Adeno-associated virus type 5 (AAV5) but not AAV2 binds to the apical surfaces of airway epithelia and facilitates gene transfer. Journal of Virology. 74: 3852-8. PMID 10729159 DOI: 10.1128/JVI.74.8.3852-3858.2000  0.72
2000 Smith RH, Kotin RM. An adeno-associated virus (AAV) initiator protein, Rep78, catalyzes the cleavage and ligation of single-stranded AAV ori DNA. Journal of Virology. 74: 3122-9. PMID 10708427 DOI: 10.1128/JVI.74.7.3122-3129.2000  0.72
2000 Davidson BL, Stein CS, Heth JA, Martins I, Kotin RM, Derksen TA, Zabner J, Ghodsi A, Chiorini JA. Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system. Proceedings of the National Academy of Sciences of the United States of America. 97: 3428-32. PMID 10688913 DOI: 10.1073/pnas.050581197  0.72
1999 Chiorini JA, Afione S, Kotin RM. Adeno-associated virus (AAV) type 5 Rep protein cleaves a unique terminal resolution site compared with other AAV serotypes. Journal of Virology. 73: 4293-8. PMID 10196327  0.72
1999 Zimmermann B, Chiorini JA, Ma Y, Kotin RM, Herberg FW. PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I. The Journal of Biological Chemistry. 274: 5370-8. PMID 10026146 DOI: 10.1074/jbc.274.9.5370  0.72
1999 Chiorini JA, Kim F, Yang L, Kotin RM. Cloning and characterization of adeno-associated virus type 5. Journal of Virology. 73: 1309-19. PMID 9882336  0.72
1998 Braddon VR, Chiorini JA, Wang S, Kotin RM, Baum BJ. Adenoassociated virus-mediated transfer of a functional water channel into salivary epithelial cells in vitro and in vivo. Human Gene Therapy. 9: 2777-85. PMID 9874275 DOI: 10.1089/hum.1998.9.18-2777  0.72
1998 Chiorini JA, Zimmermann B, Yang L, Smith RH, Ahearn A, Herberg F, Kotin RM. Inhibition of PrKX, a novel protein kinase, and the cyclic AMP-dependent protein kinase PKA by the regulatory proteins of adeno-associated virus type 2. Molecular and Cellular Biology. 18: 5921-9. PMID 9742109  0.72
1998 Maass G, Bogedain C, Scheer U, Michl D, Hörer M, Braun-Falco M, Volkenandt M, Schadendorf D, Wendtner CM, Winnacker EL, Kotin RM, Hallek M. Recombinant adeno-associated virus for the generation of autologous, gene-modified tumor vaccines: evidence for a high transduction efficiency into primary epithelial cancer cells. Human Gene Therapy. 9: 1049-59. PMID 9607416 DOI: 10.1089/hum.1998.9.7-1049  0.72
1998 Smith RH, Kotin RM. The Rep52 gene product of adeno-associated virus is a DNA helicase with 3'-to-5' polarity. Journal of Virology. 72: 4874-81. PMID 9573254  0.72
1997 Wendtner CM, Nolte A, Mangold E, Buhmann R, Maass G, Chiorini JA, Winnacker EL, Emmerich B, Kotin RM, Hallek M. Gene transfer of the costimulatory molecules B7-1 and B7-2 into human multiple myeloma cells by recombinant adeno-associated virus enhances the cytolytic T cell response. Gene Therapy. 4: 726-35. PMID 9282174 DOI: 10.1038/  0.72
1997 Chiorini JA, Yang L, Liu Y, Safer B, Kotin RM. Cloning of adeno-associated virus type 4 (AAV4) and generation of recombinant AAV4 particles. Journal of Virology. 71: 6823-33. PMID 9261407  0.72
1997 Smith RH, Spano AJ, Kotin RM. The Rep78 gene product of adeno-associated virus (AAV) self-associates to form a hexameric complex in the presence of AAV ori sequences. Journal of Virology. 71: 4461-71. PMID 9151837  0.72
1996 Chiorini JA, Wiener SM, Yang L, Smith RH, Safer B, Kilcoin NP, Liu Y, Urcelay E, Kotin RM. The roles of AAV Rep proteins in gene expression and targeted integration. Current Topics in Microbiology and Immunology. 218: 25-33. PMID 8794243  0.72
1995 Chiorini JA, Wendtner CM, Urcelay E, Safer B, Hallek M, Kotin RM. High-efficiency transfer of the T cell co-stimulatory molecule B7-2 to lymphoid cells using high-titer recombinant adeno-associated virus vectors. Human Gene Therapy. 6: 1531-41. PMID 8664378 DOI: 10.1089/hum.1995.6.12-1531  0.72
1995 Urcelay E, Ward P, Wiener SM, Safer B, Kotin RM. Asymmetric replication in vitro from a human sequence element is dependent on adeno-associated virus Rep protein. Journal of Virology. 69: 2038-46. PMID 7884849  0.72
1995 Chiorini JA, Yang L, Safer B, Kotin RM. Determination of adeno-associated virus Rep68 and Rep78 binding sites by random sequence oligonucleotide selection. Journal of Virology. 69: 7334-8. PMID 7474165  0.72
1994 Chiorini JA, Weitzman MD, Owens RA, Urcelay E, Safer B, Kotin RM. Biologically active Rep proteins of adeno-associated virus type 2 produced as fusion proteins in Escherichia coli. Journal of Virology. 68: 797-804. PMID 8289383  0.72
1994 Ward P, Urcelay E, Kotin R, Safer B, Berns KI. Adeno-associated virus DNA replication in vitro: activation by a maltose binding protein/Rep 68 fusion protein. Journal of Virology. 68: 6029-37. PMID 8057478  0.72
1994 Weitzman MD, Kyöstiö SR, Kotin RM, Owens RA. Adeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNA. Proceedings of the National Academy of Sciences of the United States of America. 91: 5808-12. PMID 8016070 DOI: 10.1073/pnas.91.13.5808  0.72
1994 Kotin RM. Prospects for the use of adeno-associated virus as a vector for human gene therapy. Human Gene Therapy. 5: 793-801. PMID 7981305 DOI: 10.1089/hum.1994.5.7-793  0.72
1994 Batchu RB, Kotin RM, Hermonat PL. The regulatory rep protein of adeno-associated virus binds to sequences within the c-H-ras promoter. Cancer Letters. 86: 23-31. PMID 7954351 DOI: 10.1016/0304-3835(94)90176-7  0.72
1994 Chiorini JA, Wiener SM, Owens RA, Kyöstió SR, Kotin RM, Safer B. Sequence requirements for stable binding and function of Rep68 on the adeno-associated virus type 2 inverted terminal repeats. Journal of Virology. 68: 7448-57. PMID 7933128  0.72
1992 Kotin RM, Linden RM, Berns KI. Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by non-homologous recombination. The Embo Journal. 11: 5071-8. PMID 1334463  0.72
1991 Kotin RM, Menninger JC, Ward DC, Berns KI. Mapping and direct visualization of a region-specific viral DNA integration site on chromosome 19q13-qter. Genomics. 10: 831-4. PMID 1653762 DOI: 10.1016/0888-7543(91)90470-Y  0.72
1990 Kotin RM, Siniscalco M, Samulski RJ, Zhu XD, Hunter L, Laughlin CA, McLaughlin S, Muzyczka N, Rocchi M, Berns KI. Site-specific integration by adeno-associated virus. Proceedings of the National Academy of Sciences of the United States of America. 87: 2211-5. PMID 2156265  0.72
1989 Kotin RM, Berns KI. Organization of adeno-associated virus DNA in latently infected Detroit 6 cells. Virology. 170: 460-7. PMID 2543124 DOI: 10.1016/0042-6822(89)90437-6  0.72
1988 Berns KI, Kotin RM, Labow MA. Regulation of adeno-associated virus DNA replication. Biochimica Et Biophysica Acta. 951: 425-9. PMID 2850017 DOI: 10.1016/0167-4781(88)90116-9  0.72
1987 Fink AL, Kar D, Kotin R. Ribonuclease structure and catalysis: Effects of crystalline enzyme, alcohol, cryosolvents, low temperatures, and product inhibition Biochemistry. 26: 8571-8579. PMID 3442677  0.72
1986 Prince DL, Kotin RM, Dubin DT. Evidence that the methylation inhibitor cycloleucine causes accumulation of a discrete ribosomal RNA precursor in hamster mitochondria. Molecular Biology Reports. 11: 51-5. PMID 3633018 DOI: 10.1007/BF00417596  0.72
1984 Kotin RM, Dubin DT. Sequences around the 3'-end of a ribosomal RNA gene of hamster mitochondria. Further support for the 'transcriptional attenuation' model. Biochimica Et Biophysica Acta. 782: 106-8. PMID 6722155 DOI: 10.1016/0167-4781(84)90112-X  0.72
1984 HsuChen CC, Kotin RM, Dubin DT. Sequences of the coding and flanking regions of the large ribosomal subunit RNA gene of mosquito mitochondria. Nucleic Acids Research. 12: 7771-85. PMID 6093053 DOI: 10.1093/nar/12.20.7771  0.72
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