R. Michael Linden, PhD - Publications

Affiliations: 
King's College London, London, UK 

44 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Musayev FN, Zarate-Perez F, Bardelli M, Bishop C, Saniev EF, Linden RM, Henckaerts E, Escalante CR. Structural Studies of AAV2 Rep68 Reveal a Partially Structured Linker and Compact Domain Conformation. Biochemistry. 54: 5907-19. PMID 26314310 DOI: 10.1021/acs.biochem.5b00610  1
2015 Petri K, Gabriel R, Agundez L, Fronza R, Afzal S, Kaeppel C, Linden RM, Henckaerts E, Schmidt M. Presence of a trs-Like Motif Promotes Rep-Mediated Wild-Type Adeno-Associated Virus Type 2 Integration. Journal of Virology. 89: 7428-32. PMID 25972561 DOI: 10.1128/JVI.00426-15  1
2014 Petri K, Fronza R, Gabriel R, Käppel C, Nowrouzi A, Linden RM, Henckaerts E, Schmidt M. Comparative next-generation sequencing of adeno-associated virus inverted terminal repeats. Biotechniques. 56: 269-73. PMID 24806228 DOI: 10.2144/000114170  1
2013 González-Prieto C, Agúndez L, Linden RM, Llosa M. HUH site-specific recombinases for targeted modification of the human genome. Trends in Biotechnology. 31: 305-12. PMID 23545167 DOI: 10.1016/j.tibtech.2013.02.002  1
2013 Zarate-Perez F, Mansilla-Soto J, Bardelli M, Burgner JW, Villamil-Jarauta M, Kekilli D, Samso M, Linden RM, Escalante CR. Oligomeric properties of adeno-associated virus Rep68 reflect its multifunctionality. Journal of Virology. 87: 1232-41. PMID 23152528 DOI: 10.1128/JVI.02441-12  1
2012 Kohlbrenner E, Henckaerts E, Rapti K, Gordon RE, Linden RM, Hajjar RJ, Weber T. Quantification of AAV particle titers by infrared fluorescence scanning of coomassie-stained sodium dodecyl sulfate-polyacrylamide gels. Human Gene Therapy Methods. 23: 198-203. PMID 22816378 DOI: 10.1089/hgtb.2012.049  0.48
2012 Zarate-Perez F, Bardelli M, Burgner JW, Villamil-Jarauta M, Das K, Kekilli D, Mansilla-Soto J, Linden RM, Escalante CR. The interdomain linker of AAV-2 Rep68 is an integral part of its oligomerization domain: role of a conserved SF3 helicase residue in oligomerization. Plos Pathogens. 8: e1002764. PMID 22719256 DOI: 10.1371/journal.ppat.1002764  1
2011 Weitzman MD, Linden RM. Adeno-associated virus biology. Methods in Molecular Biology (Clifton, N.J.). 807: 1-23. PMID 22034024 DOI: 10.1007/978-1-61779-370-7_1  1
2010 Henckaerts E, Linden RM. Adeno-associated virus: a key to the human genome? Future Virology. 5: 555-574. PMID 21212830 DOI: 10.2217/fvl.10.48  1
2010 Wang X, Blanchard J, Kohlbrenner E, Clement N, Linden RM, Radu A, Grundke-Iqbal I, Iqbal K. The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 4420-32. PMID 20651003 DOI: 10.1096/fj.10-158477  1
2010 Zeltner N, Kohlbrenner E, Clément N, Weber T, Linden RM. Near-perfect infectivity of wild-type AAV as benchmark for infectivity of recombinant AAV vectors. Gene Therapy. 17: 872-9. PMID 20336156 DOI: 10.1038/gt.2010.27  1
2009 Dutheil N, Henckaerts E, Kohlbrenner E, Linden RM. Transcriptional analysis of the adeno-associated virus integration site. Journal of Virology. 83: 12512-25. PMID 19759129 DOI: 10.1128/JVI.01754-09  1
2009 Clément N, Battaglioli G, Jensen RL, Schnepp BC, Johnson PR, St George K, Linden RM. Prevalence of human bocavirus in human tonsils and adenoids. Emerging Infectious Diseases. 15: 1149-50. PMID 19624951 DOI: 10.3201/eid1507.090102  1
2009 Mansilla-Soto J, Yoon-Robarts M, Rice WJ, Arya S, Escalante CR, Linden RM. DNA structure modulates the oligomerization properties of the AAV initiator protein Rep68. Plos Pathogens. 5: e1000513. PMID 19593381 DOI: 10.1371/journal.ppat.1000513  1
2009 Henckaerts E, Dutheil N, Zeltner N, Kattman S, Kohlbrenner E, Ward P, Clément N, Rebollo P, Kennedy M, Keller GM, Linden RM. Site-specific integration of adeno-associated virus involves partial duplication of the target locus. Proceedings of the National Academy of Sciences of the United States of America. 106: 7571-6. PMID 19372372 DOI: 10.1073/pnas.0806821106  1
2008 Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, Henckaerts E, Bonham K, Abbott GW, Linden RM, Field LJ, Keller GM. Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature. 453: 524-8. PMID 18432194 DOI: 10.1038/nature06894  1
2007 Ward P, Clément N, Linden RM. cis effects in adeno-associated virus type 2 replication. Journal of Virology. 81: 9976-89. PMID 17626079 DOI: 10.1128/JVI.00630-07  1
2007 Hirosue S, Senn K, Clément N, Nonnenmacher M, Gigout L, Linden RM, Weber T. Effect of inhibition of dynein function and microtubule-altering drugs on AAV2 transduction. Virology. 367: 10-8. PMID 17588632 DOI: 10.1016/j.virol.2007.05.009  1
2007 Glauser DL, Strasser R, Laimbacher AS, Saydam O, Clément N, Linden RM, Ackermann M, Fraefel C. Live covisualization of competing adeno-associated virus and herpes simplex virus type 1 DNA replication: molecular mechanisms of interaction. Journal of Virology. 81: 4732-43. PMID 17314170 DOI: 10.1128/JVI.02476-06  1
2006 Vasileva A, Linden RM, Jessberger R. Homologous recombination is required for AAV-mediated gene targeting. Nucleic Acids Research. 34: 3345-60. PMID 16822856 DOI: 10.1093/nar/gkl455  1
2005 Zhang N, Clément N, Chen D, Fu S, Zhang H, Rebollo P, Linden RM, Bromberg JS. Transduction of pancreatic islets with pseudotyped adeno-associated virus: effect of viral capsid and genome conversion. Transplantation. 80: 683-90. PMID 16177645 DOI: 10.1097/01.tp.0000173381.97556.0d  1
2005 Glauser DL, Saydam O, Balsiger NA, Heid I, Linden RM, Ackermann M, Fraefel C. Four-dimensional visualization of the simultaneous activity of alternative adeno-associated virus replication origins. Journal of Virology. 79: 12218-30. PMID 16160148 DOI: 10.1128/JVI.79.19.12218-12230.2005  1
2005 Gigout L, Rebollo P, Clement N, Warrington KH, Muzyczka N, Linden RM, Weber T. Altering AAV tropism with mosaic viral capsids. Molecular Therapy : the Journal of the American Society of Gene Therapy. 11: 856-65. PMID 15922956 DOI: 10.1016/j.ymthe.2005.03.005  1
2004 Yoon-Robarts M, Blouin AG, Bleker S, Kleinschmidt JA, Aggarwal AK, Escalante CR, Linden RM. Residues within the B' motif are critical for DNA binding by the superfamily 3 helicase Rep40 of adeno-associated virus type 2. The Journal of Biological Chemistry. 279: 50472-81. PMID 15371437 DOI: 10.1074/jbc.M403900200  1
2004 James JA, Aggarwal AK, Linden RM, Escalante CR. Structure of adeno-associated virus type 2 Rep40-ADP complex: insight into nucleotide recognition and catalysis by superfamily 3 helicases. Proceedings of the National Academy of Sciences of the United States of America. 101: 12455-60. PMID 15310852 DOI: 10.1073/pnas.0403454101  1
2004 Dutheil N, Yoon-Robarts M, Ward P, Henckaerts E, Skrabanek L, Berns KI, Campagne F, Linden RM. Characterization of the mouse adeno-associated virus AAVS1 ortholog. Journal of Virology. 78: 8917-21. PMID 15280500 DOI: 10.1128/JVI.78.16.8917-8921.2004  1
2003 Ward P, Elias P, Linden RM. Rescue of the adeno-associated virus genome from a plasmid vector: evidence for rescue by replication. Journal of Virology. 77: 11480-90. PMID 14557633 DOI: 10.1128/JVI.77.21.11480-11490.2003  1
2003 James JA, Escalante CR, Yoon-Robarts M, Edwards TA, Linden RM, Aggarwal AK. Crystal structure of the SF3 helicase from adeno-associated virus type 2. Structure (London, England : 1993). 11: 1025-35. PMID 12906833 DOI: 10.1016/S0969-2126(03)00152-7  1
2003 Yoon-Robarts M, Linden RM. Identification of active site residues of the adeno-associated virus type 2 Rep endonuclease. The Journal of Biological Chemistry. 278: 4912-8. PMID 12480938 DOI: 10.1074/jbc.M209750200  1
2002 Linden RM. Gene therapy gets the Beauty treatment. Nature Biotechnology. 20: 987-8. PMID 12355113 DOI: 10.1038/nbt1002-987  1
2001 Ward P, Falkenberg M, Elias P, Weitzman M, Linden RM. Rep-dependent initiation of adeno-associated virus type 2 DNA replication by a herpes simplex virus type 1 replication complex in a reconstituted system. Journal of Virology. 75: 10250-8. PMID 11581393 DOI: 10.1128/JVI.75.21.10250-10258.2001  1
2001 Nony P, Tessier J, Chadeuf G, Ward P, Giraud A, Dugast M, Linden RM, Moullier P, Salvetti A. Novel cis-acting replication element in the adeno-associated virus type 2 genome is involved in amplification of integrated rep-cap sequences. Journal of Virology. 75: 9991-4. PMID 11559833 DOI: 10.1128/JVI.75.20.9991-9994.2001  1
2001 Yoon M, Smith DH, Ward P, Medrano FJ, Aggarwal AK, Linden RM. Amino-terminal domain exchange redirects origin-specific interactions of adeno-associated virus rep78 in vitro. Journal of Virology. 75: 3230-9. PMID 11238849 DOI: 10.1128/JVI.75.7.3230-3239.2001  1
2000 Linden RM, Berns KI. Molecular biology of adeno-associated viruses. Contributions to Microbiology. 4: 68-84. PMID 10941571  1
2000 Dutheil N, Shi F, Dupressoir T, Linden RM. Adeno-associated virus site-specifically integrates into a muscle-specific DNA region. Proceedings of the National Academy of Sciences of the United States of America. 97: 4862-6. PMID 10758163 DOI: 10.1073/pnas.080079397  1
2000 Ward P, Linden RM. A role for single-stranded templates in cell-free adeno-associated virus DNA replication. Journal of Virology. 74: 744-54. PMID 10623736 DOI: 10.1128/JVI.74.2.744-754.2000  1
1999 Smith DH, Ward P, Linden RM. Comparative characterization of rep proteins from the helper-dependent adeno-associated virus type 2 and the autonomous goose parvovirus. Journal of Virology. 73: 2930-7. PMID 10074142  1
1999 Linden RM, Woo SL. AAVant-garde gene therapy. Nature Medicine. 5: 21-2. PMID 9883831 DOI: 10.1038/4698  1
1997 Linden RM, Berns KI. Site-specific integration by adeno-associated virus: a basis for a potential gene therapy vector. Gene Therapy. 4: 4-5. PMID 9068788 DOI: 10.1038/sj.gt.3300357  1
1996 Linden RM, Ward P, Giraud C, Winocour E, Berns KI. Site-specific integration by adeno-associated virus. Proceedings of the National Academy of Sciences of the United States of America. 93: 11288-94. PMID 8876128 DOI: 10.1073/pnas.93.21.11288  1
1996 Linden RM, Winocour E, Berns KI. The recombination signals for adeno-associated virus site-specific integration. Proceedings of the National Academy of Sciences of the United States of America. 93: 7966-72. PMID 8755586 DOI: 10.1073/pnas.93.15.7966  1
1995 Berns KI, Linden RM. The cryptic life style of adeno-associated virus. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 17: 237-45. PMID 7748178 DOI: 10.1002/bies.950170310  1
1992 Schilling B, Linden RM, Kupper U, Lerch K. Expression of Neurospora crassa laccase under the control of the copper-inducible metallothionein-promoter. Current Genetics. 22: 197-203. PMID 1388108 DOI: 10.1007/BF00351726  1
1992 Kotin RM, Linden RM, Berns KI. Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by non-homologous recombination. The Embo Journal. 11: 5071-8. PMID 1334463  1
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