Michael J. Mitchell, Ph.D. - Publications

Affiliations: 
Department of Bioengineering University of Pennsylvania, Philadelphia, PA, United States 

92 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Xue L, Zhao G, Gong N, Han X, Shepherd SJ, Xiong X, Xiao Z, Palanki R, Xu J, Swingle KL, Warzecha CC, El-Mayta R, Chowdhary V, Yoon IC, Xu J, ... ... Mitchell MJ, et al. Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery. Nature Nanotechnology. PMID 39354147 DOI: 10.1038/s41565-024-01747-6  0.301
2024 Kim EH, Teerdhala SV, Padilla MS, Joseph RA, Li JJ, Haley RM, Mitchell MJ. Lipid nanoparticle-mediated RNA delivery for immune cell modulation. European Journal of Immunology. e2451008. PMID 39279550 DOI: 10.1002/eji.202451008  0.357
2024 Palanki R, Riley JS, Bose SK, Luks V, Dave A, Kus N, White BM, Ricciardi AS, Swingle KL, Xue L, Sung D, Thatte AS, Safford HC, Chaluvadi VS, Carpenter M, ... ... Mitchell MJ, et al. In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 121: e2400783121. PMID 39078677 DOI: 10.1073/pnas.2400783121  0.725
2024 Palanki R, Han EL, Murray AM, Maganti R, Tang S, Swingle KL, Kim D, Yamagata H, Safford HC, Mrksich K, Peranteau WH, Mitchell MJ. Optimized microfluidic formulation and organic excipients for improved lipid nanoparticle mediated genome editing. Lab On a Chip. PMID 39037068 DOI: 10.1039/d4lc00283k  0.312
2024 Hamilton AG, Swingle KL, Thatte AS, Mukalel AJ, Safford HC, Billingsley MM, El-Mayta RD, Han X, Nachod BE, Joseph RA, Metzloff AE, Mitchell MJ. High-Throughput Screening Identifies Differential Influences on mRNA Lipid Nanoparticle Immune Cell Delivery by Administration Route. Acs Nano. PMID 38861479 DOI: 10.1021/acsnano.4c01171  0.801
2024 Geisler HC, Ghalsasi AA, Safford HC, Swingle KL, Thatte AS, Mukalel AJ, Gong N, Hamilton AG, Han EL, Nachod BE, Padilla MS, Mitchell MJ. EGFR-targeted ionizable lipid nanoparticles enhance in vivo mRNA delivery to the placenta. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 38789090 DOI: 10.1016/j.jconrel.2024.05.036  0.794
2024 Atsavapranee E, Haley RM, Billingsley MM, Chan A, Ruan B, Figueroa-Espada CG, Gong N, Mukalel AJ, Bryan PN, Mitchell MJ. Ionizable lipid nanoparticles for RAS protease delivery to inhibit cancer cell proliferation. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 38729436 DOI: 10.1016/j.jconrel.2024.05.015  0.794
2024 Gong N, Han X, Xue L, Billingsley MM, Huang X, El-Mayta R, Qin J, Sheppard NC, June CH, Mitchell MJ. Author Correction: Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager. Nature Biomedical Engineering. PMID 38491330 DOI: 10.1038/s41551-024-01198-3  0.678
2024 Xue L, Hamilton AG, Zhao G, Xiao Z, El-Mayta R, Han X, Gong N, Xiong X, Xu J, Figueroa-Espada CG, Shepherd SJ, Mukalel AJ, Alameh MG, Cui J, Wang K, ... ... Mitchell MJ, et al. High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models. Nature Communications. 15: 1884. PMID 38424061 DOI: 10.1038/s41467-024-45422-9  0.8
2024 Metzloff AE, Padilla MS, Gong N, Billingsley MM, Han X, Merolle M, Mai D, Figueroa-Espada CG, Thatte AS, Haley RM, Mukalel AJ, Hamilton AG, Alameh MG, Weissman D, Sheppard NC, ... ... Mitchell MJ, et al. Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy. Advanced Materials (Deerfield Beach, Fla.). e2313226. PMID 38419362 DOI: 10.1002/adma.202313226  0.799
2024 Gong N, Han X, Xue L, Billingsley MM, Huang X, El-Mayta R, Qin J, Sheppard NC, June CH, Mitchell MJ. Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager. Nature Biomedical Engineering. PMID 38378820 DOI: 10.1038/s41551-023-01147-6  0.697
2024 Thatte AS, Billingsley MM, Weissman D, Melamed JR, Mitchell MJ. Emerging strategies for nanomedicine in autoimmunity. Advanced Drug Delivery Reviews. 207: 115194. PMID 38342243 DOI: 10.1016/j.addr.2024.115194  0.702
2024 Guimaraes LC, Costa PAC, Scalzo Júnior SRA, Ferreira HAS, Braga ACS, de Oliveira LC, Figueiredo MM, Shepherd S, Hamilton A, Queiroz-Junior CM, da Silva WN, da Silva NJA, Rodrigues Alves MT, Santos AK, de Faria KKS, ... ... Mitchell MJ, et al. Nanoparticle-based DNA vaccine protects against SARS-CoV-2 variants in female preclinical models. Nature Communications. 15: 590. PMID 38238326 DOI: 10.1038/s41467-024-44830-1  0.679
2024 Patel SK, Billingsley MM, Mukalel AJ, Thatte AS, Hamilton AG, Gong N, El-Mayta R, Safford HC, Merolle M, Mitchell MJ. Bile acid-containing lipid nanoparticles enhance extrahepatic mRNA delivery. Theranostics. 14: 1-16. PMID 38164140 DOI: 10.7150/thno.89913  0.804
2023 Mossburg KJ, Shepherd SJ, Barragan D, O NH, Berkow EK, Maidment PSN, Berrios DNR, Hsu JC, Siedlik MJ, Yadavali S, Mitchell MJ, Issadore D, Cormode DP. Towards the Clinical Translation of a Silver Sulfide Nanoparticle Contrast Agent: Large Scale Production with a Highly Parallelized Microfluidic Chip. Biorxiv : the Preprint Server For Biology. PMID 38106126 DOI: 10.1101/2023.12.02.569706  0.655
2023 Billingsley MM, Gong N, Mukalel AJ, Thatte AS, El-Mayta R, Patel SK, Metzloff AE, Swingle KL, Han X, Xue L, Hamilton AG, Safford HC, Alameh MG, Papp TE, Parhiz H, ... ... Mitchell MJ, et al. In Vivo mRNA CAR T Cell Engineering via Targeted Ionizable Lipid Nanoparticles with Extrahepatic Tropism. Small (Weinheim An Der Bergstrasse, Germany). e2304378. PMID 38072809 DOI: 10.1002/smll.202304378  0.812
2023 Thatte AS, Hamilton AG, Nachod BE, Mukalel AJ, Billingsley MM, Palanki R, Swingle KL, Mitchell MJ. mRNA Lipid Nanoparticles for Engineering of Immunosuppressive T Cells for Autoimmunity Therapies. Nano Letters. PMID 37906000 DOI: 10.1021/acs.nanolett.3c02573  0.79
2023 Prazeres PHDM, Ferreira H, Costa PAC, da Silva W, Alves MT, Padilla M, Thatte A, Santos AK, Lobo AO, Sabino A, Del Puerto HL, Mitchell MJ, Guimaraes PPG. Delivery of Plasmid DNA by Ionizable Lipid Nanoparticles to Induce CAR Expression in T Cells. International Journal of Nanomedicine. 18: 5891-5904. PMID 37873551 DOI: 10.2147/IJN.S424723  0.306
2023 Figueroa-Espada CG, Guimarães PPG, Riley RS, Xue L, Wang K, Mitchell MJ. siRNA Lipid-Polymer Nanoparticles Targeting E-Selectin and Cyclophilin A in Bone Marrow for Combination Multiple Myeloma Therapy. Cellular and Molecular Bioengineering. 16: 383-392. PMID 37810998 DOI: 10.1007/s12195-023-00774-y  0.693
2023 Gong N, Han X, Xue L, El-Mayta R, Metzloff AE, Billingsley MM, Hamilton AG, Mitchell MJ. In situ PEGylation of CAR T cells alleviates cytokine release syndrome and neurotoxicity. Nature Materials. PMID 37696939 DOI: 10.1038/s41563-023-01646-6  0.701
2023 Hamilton AG, Swingle KL, Joseph RA, Mai D, Gong N, Billingsley MM, Alameh MG, Weissman D, Sheppard NC, June CH, Mitchell MJ. Lonizable Lipid Nanoparticles with Integrated Immune Checkpoint Inhibition for mRNA CAR T Cell Engineering. Advanced Healthcare Materials. e2301515. PMID 37602495 DOI: 10.1002/adhm.202301515  0.726
2023 Shepherd SJ, Han X, Mukalel AJ, El-Mayta R, Thatte AS, Wu J, Padilla MS, Alameh MG, Srikumar N, Lee D, Weissman D, Issadore D, Mitchell MJ. Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines. Proceedings of the National Academy of Sciences of the United States of America. 120: e2303567120. PMID 37556502 DOI: 10.1073/pnas.2303567120  0.785
2023 Safford HC, Swingle KL, Geisler HC, Hamilton AG, Thatte AS, Ghalsasi AA, Billingsley MM, Alameh MG, Weissman D, Mitchell MJ. Orthogonal Design of Experiments for Engineering of Lipid Nanoparticles for mRNA Delivery to the Placenta. Small (Weinheim An Der Bergstrasse, Germany). e2303568. PMID 37537704 DOI: 10.1002/smll.202303568  0.735
2023 Palanki R, Bose SK, Dave A, White BM, Berkowitz C, Luks V, Yaqoob F, Han E, Swingle KL, Menon P, Hodgson E, Biswas A, Billingsley MM, Li L, Yiping F, ... ... Mitchell MJ, et al. Ionizable Lipid Nanoparticles for Therapeutic Base Editing of Congenital Brain Disease. Acs Nano. PMID 37458484 DOI: 10.1021/acsnano.3c02268  0.703
2023 Nong J, Glassman PM, Myerson JW, Zuluaga-Ramirez V, Rodriguez-Garcia A, Mukalel A, Omo-Lamai S, Walsh LR, Zamora ME, Gong X, Wang Z, Bhamidipati K, Kiseleva RY, Villa CH, Greineder CF, ... ... Mitchell MJ, et al. Targeted Nanocarriers Co-Opting Pulmonary Intravascular Leukocytes for Drug Delivery to the Injured Brain. Acs Nano. PMID 37432926 DOI: 10.1021/acsnano.2c08275  0.764
2023 Guimarães PPG, Figueroa-Espada CG, Riley RS, Gong N, Xue L, Sewastianik T, Dennis PS, Loebel C, Chung A, Shepherd SJ, Haley RM, Hamilton AG, El-Mayta R, Wang K, Langer R, ... ... Mitchell MJ, et al. In vivo bone marrow microenvironment siRNA delivery using lipid-polymer nanoparticles for multiple myeloma therapy. Proceedings of the National Academy of Sciences of the United States of America. 120: e2215711120. PMID 37310997 DOI: 10.1073/pnas.2215711120  0.786
2023 Haley RM, Chan A, Billingsley MM, Gong N, Padilla MS, Kim EH, Wang H, Yin D, Wangensteen KJ, Tsourkas A, Mitchell MJ. Lipid Nanoparticle Delivery of Small Proteins for Potent RAS Inhibition. Acs Applied Materials & Interfaces. PMID 37115558 DOI: 10.1021/acsami.3c01501  0.7
2023 McDonald CL, Qasba P, Anderson DG, Bao G, Colvin RA, Kohn DB, Malik P, Mitchell MJ, Pu WT, Rawlings DJ, Williams DA, Flotte TR. Future Directions and Resource Needs for National Heart, Lung, and Blood Institute (NHLBI) Gene Therapy Research: A Report of an NHLBI Workshop. Human Gene Therapy. 34: 83-89. PMID 36794978 DOI: 10.1089/hum.2022.29233.tga  0.317
2023 Swingle KL, Safford HC, Geisler HC, Hamilton AG, Thatte AS, Billingsley MM, Joseph RA, Mrksich K, Padilla MS, Ghalsasi AA, Alameh MG, Weissman D, Mitchell MJ. Ionizable Lipid Nanoparticles for mRNA Delivery to the Placenta during Pregnancy. Journal of the American Chemical Society. PMID 36789893 DOI: 10.1021/jacs.2c12893  0.727
2023 El-Mayta R, Padilla MS, Billingsley MM, Han X, Mitchell MJ. Testing the In Vitro and In Vivo Efficiency of mRNA-Lipid Nanoparticles Formulated by Microfluidic Mixing. Journal of Visualized Experiments : Jove. PMID 36744791 DOI: 10.3791/64810  0.723
2023 Bashiri G, Padilla MS, Swingle KL, Shepherd SJ, Mitchell MJ, Wang K. Nanoparticle protein corona: from structure and function to therapeutic targeting. Lab On a Chip. PMID 36655824 DOI: 10.1039/d2lc00799a  0.657
2023 Han X, Gong N, Xue L, Billingsley MM, El-Mayta R, Shepherd SJ, Alameh MG, Weissman D, Mitchell MJ. Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis. Nature Communications. 14: 75. PMID 36650129 DOI: 10.1038/s41467-022-35637-z  0.797
2022 Butowska K, Han X, Gong N, El-Mayta R, Haley RM, Xue L, Zhong W, Guo W, Wang K, Mitchell MJ. Doxorubicin-conjugated siRNA lipid nanoparticles for combination cancer therapy. Acta Pharmaceutica Sinica. B. 13: 1429-1437. PMID 37139433 DOI: 10.1016/j.apsb.2022.07.011  0.307
2022 Qin J, Xue L, Gong N, Zhang H, Shepherd SJ, Haley RM, Swingle KL, Mitchell MJ. RGD peptide-based lipids for targeted mRNA delivery and gene editing applications. Rsc Advances. 12: 25397-25404. PMID 36199352 DOI: 10.1039/d2ra02771b  0.716
2022 Xue L, Gong N, Shepherd SJ, Xiong X, Liao X, Han X, Zhao G, Song C, Huang X, Zhang H, Padilla MS, Qin J, Shi Y, Alameh MG, Pochan DJ, ... ... Mitchell MJ, et al. Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment. Journal of the American Chemical Society. PMID 35616998 DOI: 10.1021/jacs.2c02706  0.666
2022 Patel SK, Billingsley MM, Frazee C, Han X, Swingle KL, Qin J, Alameh MG, Wang K, Weissman D, Mitchell MJ. Hydroxycholesterol substitution in Ionizable lipid nanoparticles for mRNA delivery to T cells. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 35569584 DOI: 10.1016/j.jconrel.2022.05.020  0.757
2022 Metzloff AE, Billingsley MM, Mitchell MJ. Lighting the way to personalized mRNA immune cell therapies. Science Advances. 8: eabo2423. PMID 35196095 DOI: 10.1126/sciadv.abo2423  0.703
2022 Zhang H, Han X, Alameh MG, Shepherd SJ, Padilla MS, Xue L, Butowska K, Weissman D, Mitchell MJ. Rational design of anti-inflammatory lipid nanoparticles for mRNA delivery. Journal of Biomedical Materials Research. Part A. PMID 35076171 DOI: 10.1002/jbm.a.37356  0.7
2021 Parhiz H, Brenner JS, Patel P, Papp TE, Shahnawaz H, Li Q, Shi R, Zamora M, Yadegari A, Marcos-Contreras OA, Natesan A, Pardi N, Shuvaev VV, Kiseleva R, Myerson J, ... ... Mitchell MJ, et al. Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE). Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 34953981 DOI: 10.1016/j.jconrel.2021.12.027  0.697
2021 Swingle KL, Billingsley MM, Bose SK, White B, Palanki R, Dave A, Patel SK, Gong N, Hamilton AG, Alameh MG, Weissman D, Peranteau WH, Mitchell MJ. Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic mRNA delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 34742747 DOI: 10.1016/j.jconrel.2021.10.031  0.727
2021 Billingsley MM, Hamilton AG, Mai D, Patel SK, Swingle KL, Sheppard NC, June CH, Mitchell MJ. Orthogonal Design of Experiments for Optimization of Lipid Nanoparticles for mRNA Engineering of CAR T Cells. Nano Letters. PMID 34669421 DOI: 10.1021/acs.nanolett.1c02503  0.749
2021 Zhang D, Atochina-Vasserman EN, Maurya DS, Huang N, Xiao Q, Ona N, Liu M, Shahnawaz H, Ni H, Kim K, Billingsley MM, Pochan DJ, Mitchell MJ, Weissman D, Percec V. One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA. Journal of the American Chemical Society. PMID 34324336 DOI: 10.1021/jacs.1c05813  0.73
2021 Shepherd SJ, Warzecha CC, Yadavali S, El-Mayta R, Alameh MG, Wang L, Weissman D, Wilson JM, Issadore D, Mitchell MJ. Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device. Nano Letters. PMID 34189917 DOI: 10.1021/acs.nanolett.1c01353  0.7
2021 Shepherd SJ, Issadore D, Mitchell MJ. Microfluidic formulation of nanoparticles for biomedical applications. Biomaterials. 274: 120826. PMID 33965797 DOI: 10.1016/j.biomaterials.2021.120826  0.671
2021 Atsavapranee ES, Billingsley MM, Mitchell MJ. Delivery technologies for T cell gene editing: Applications in cancer immunotherapy. Ebiomedicine. 67: 103354. PMID 33910123 DOI: 10.1016/j.ebiom.2021.103354  0.716
2021 Riley RS, Kashyap MV, Billingsley MM, White B, Alameh MG, Bose SK, Zoltick PW, Li H, Zhang R, Cheng AY, Weissman D, Peranteau WH, Mitchell MJ. Ionizable lipid nanoparticles for in utero mRNA delivery. Science Advances. 7. PMID 33523869 DOI: 10.1126/sciadv.aba1028  0.815
2021 Gong N, Sheppard NC, Billingsley MM, June CH, Mitchell MJ. Nanomaterials for T-cell cancer immunotherapy. Nature Nanotechnology. 16: 25-36. PMID 33437036 DOI: 10.1038/s41565-020-00822-y  0.712
2021 Zhang R, El-Mayta R, Murdoch TJ, Warzecha CC, Billingsley MM, Shepherd SJ, Gong N, Wang L, Wilson JM, Lee D, Mitchell MJ. Helper lipid structure influences protein adsorption and delivery of lipid nanoparticles to spleen and liver. Biomaterials Science. PMID 33404020 DOI: 10.1039/d0bm01609h  0.804
2020 Mitchell MJ, Billingsley MM, Haley RM, Wechsler ME, Peppas NA, Langer R. Engineering precision nanoparticles for drug delivery. Nature Reviews. Drug Discovery. PMID 33277608 DOI: 10.1038/s41573-020-0090-8  0.735
2020 Krohn-Grimberghe M, Mitchell MJ, Schloss MJ, Khan OF, Courties G, Guimaraes PPG, Rohde D, Cremer S, Kowalski PS, Sun Y, Tan M, Webster J, Wang K, Iwamoto Y, Schmidt SP, et al. Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche. Nature Biomedical Engineering. PMID 33020600 DOI: 10.1038/s41551-020-00623-7  0.527
2020 Figueroa-Espada CG, Mitchell MJ, Riley RS. Exploiting the placenta for nanoparticle-mediated drug delivery during pregnancy. Advanced Drug Delivery Reviews. PMID 32956719 DOI: 10.1016/J.Addr.2020.09.006  0.719
2020 Choueiri TK, Atkins MB, Bakouny Z, Carlo MI, Drake CG, Jonasch E, Kapur P, Lewis B, Linehan WM, Mitchell MJ, Pal SK, Pels K, Poteat S, Rathmell WK, Rini BI, et al. Summary from the First Kidney Cancer Research Summit, September 12-13, 2019: A Focus on Translational Research. Journal of the National Cancer Institute. PMID 32359162 DOI: 10.1093/Jnci/Djaa064  0.307
2020 Haley RM, Gottardi R, Langer R, Mitchell MJ. Cyclodextrins in drug delivery: applications in gene and combination therapy. Drug Delivery and Translational Research. PMID 32077052 DOI: 10.1007/S13346-020-00724-5  0.456
2020 Billingsley M, Singh N, Ravikumar P, Zhang R, June CH, Mitchell MJ. Ionizable Lipid Nanoparticle Mediated mRNA Delivery for Human CAR T Cell Engineering. Nano Letters. PMID 31951421 DOI: 10.1021/Acs.Nanolett.9B04246  0.765
2019 Yeom J, Guimaraes PPG, Ahn HM, Jung BK, Hu Q, McHugh K, Mitchell MJ, Yun CO, Langer R, Jaklenec A. Chiral Supraparticles for Controllable Nanomedicine. Advanced Materials (Deerfield Beach, Fla.). e1903878. PMID 31686433 DOI: 10.1002/Adma.201903878  0.42
2019 Guimaraes PP, Zhang R, Spektor R, Tan M, Chung A, Billingsley MM, El-Mayta R, Riley RS, Wang L, Wilson JM, Mitchell MJ. Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 31678653 DOI: 10.1016/J.Jconrel.2019.10.028  0.808
2019 Mukalel AJ, Riley RS, Zhang R, Mitchell MJ. Nanoparticles for Nucleic Acid Delivery: Applications in Cancer Immunotherapy. Cancer Letters. PMID 31100411 DOI: 10.1016/J.Canlet.2019.04.040  0.809
2019 Riley RS, June CH, Langer R, Mitchell MJ. Delivery technologies for cancer immunotherapy. Nature Reviews. Drug Discovery. PMID 30622344 DOI: 10.1038/S41573-018-0006-Z  0.76
2018 Bisso PW, Gaglione S, Guimarães PPG, Mitchell MJ, Langer R. Nanomaterial Interactions with Human Neutrophils. Acs Biomaterials Science & Engineering. 4: 4255-4265. PMID 31497639 DOI: 10.1021/Acsbiomaterials.8B01062  0.408
2018 Mitchell MJ, Jain RK, Langer R. Publisher Correction: Engineering and physical sciences in oncology: challenges and opportunities. Nature Reviews. Cancer. PMID 30337715 DOI: 10.1038/S41568-018-0072-X  0.337
2018 Zhang R, Billingsley MM, Mitchell MJ. Biomaterials for vaccine-based cancer immunotherapy. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 30312721 DOI: 10.1016/J.Jconrel.2018.10.008  0.721
2018 Guimaraes PPG, Tan M, Tammela T, Wu K, Chung A, Oberli M, Wang K, Spektor R, Riley RS, Viana CTR, Jacks T, Langer R, Mitchell MJ. Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 30290244 DOI: 10.1016/J.Jconrel.2018.09.025  0.718
2018 Fenton OS, Olafson KN, Pillai PS, Mitchell MJ, Langer R. Advances in Biomaterials for Drug Delivery. Advanced Materials (Deerfield Beach, Fla.). e1705328. PMID 29736981 DOI: 10.1002/Adma.201705328  0.439
2018 Guimaraes PPG, Gaglione S, Sewastianik T, Carrasco RD, Langer R, Mitchell MJ. Nanoparticles for Immune Cytokine TRAIL-Based Cancer Therapy. Acs Nano. PMID 29378114 DOI: 10.1021/Acsnano.7B05876  0.518
2017 Mitchell MJ, Jain RK, Langer R. Engineering and physical sciences in oncology: challenges and opportunities. Nature Reviews. Cancer. PMID 29026204 DOI: 10.1038/Nrc.2017.83  0.403
2017 Nasajpour A, Mandla S, Shree S, Mostafavi E, Sharifi R, Khalilpour A, Saghazadeh S, Hassan S, Mitchell MJ, Leijten J, Hou X, Moshaverinia A, Annabi N, Adelung R, Mishra YK, et al. Nanostructured fibrous membranes with rose spike-like architecture. Nano Letters. PMID 28819978 DOI: 10.1021/Acs.Nanolett.7B02929  0.461
2017 Mitchell MJ, Webster J, Chung A, Guimarães PP, Khan OF, Langer R. Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis. Nature Communications. 8: 14179. PMID 28317839 DOI: 10.1038/Ncomms14179  0.452
2017 Oberli MA, Reichmuth AM, Dorkin JR, Mitchell MJ, Fenton OS, Jaklenec A, Anderson DG, Langer R, Blankschtein D. Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy. Nano Letters. 17: 1326-1335. PMID 28273716 DOI: 10.1021/Acs.Nanolett.6B03329  0.6
2017 Mitchell MJ, Langer R. Abstract PR09: Polymeric mechanical amplifiers of tumor apoptosis Cancer Research. 77. DOI: 10.1158/1538-7445.Epso16-Pr09  0.34
2016 Mitchell MJ, Langer R. Abstract 3901: Polymeric mechanical amplifiers of tumor cell receptor-mediated apoptosis Cancer Research. 76: 3901-3901. DOI: 10.1158/1538-7445.Am2016-3901  0.411
2015 Wayne EC, Chandrasekaran S, Mitchell MJ, Chan MF, Lee RE, Schaffer CB, King MR. TRAIL-coated leukocytes that prevent the bloodborne metastasis of prostate cancer. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 26732555 DOI: 10.1016/J.Jconrel.2015.12.048  0.482
2015 Mitchell MJ, Denais C, Chan M, Wang Z, Lammerding J, King MR. Lamin A/C Deficiency Reduces Circulating Tumor Cell Resistance to Fluid Shear Stress. American Journal of Physiology. Cell Physiology. ajpcell.00050.2015. PMID 26447202 DOI: 10.1152/Ajpcell.00050.2015  0.455
2015 Mitchell MJ, Castellanos CA, King MR. Surfactant functionalization induces robust, differential adhesion of tumor cells and blood cells to charged nanotube-coated biomaterials under flow. Biomaterials. 56: 179-86. PMID 25934290 DOI: 10.1016/J.Biomaterials.2015.03.045  0.493
2015 Mitchell MJ, Castellanos CA, King MR. Immobilized surfactant-nanotube complexes support selectin-mediated capture of viable circulating tumor cells in the absence of capture antibodies. Journal of Biomedical Materials Research. Part A. PMID 25761664 DOI: 10.1002/Jbm.A.35445  0.482
2015 Kohn JC, Zhou DW, Bordeleau F, Zhou AL, Mason BN, Mitchell MJ, King MR, Reinhart-King CA. Cooperative effects of matrix stiffness and fluid shear stress on endothelial cell behavior. Biophysical Journal. 108: 471-8. PMID 25650915 DOI: 10.1016/J.Bpj.2014.12.023  0.567
2015 Mitchell MJ, King MR. Leukocytes as carriers for targeted cancer drug delivery. Expert Opinion On Drug Delivery. 12: 375-92. PMID 25270379 DOI: 10.1517/17425247.2015.966684  0.524
2014 Bajpai S, Mitchell MJ, King MR, Reinhart-King CA. A microfluidic device to select for cells based on chemotactic phenotype. Technology. 2: 101-105. PMID 24999488 DOI: 10.1142/S2339547814200015  0.382
2014 Mitchell MJ, Lin KS, King MR. Fluid shear stress increases neutrophil activation via platelet-activating factor. Biophysical Journal. 106: 2243-53. PMID 24853753 DOI: 10.1016/J.Bpj.2014.04.001  0.409
2014 Mitchell MJ, King MR. Unnatural killer cells to prevent bloodborne metastasis: inspiration from biology and engineering. Expert Review of Anticancer Therapy. 14: 641-4. PMID 24791860 DOI: 10.1586/14737140.2014.916619  0.515
2014 Mitchell MJ, Wayne E, Rana K, Schaffer CB, King MR. TRAIL-coated leukocytes that kill cancer cells in the circulation. Proceedings of the National Academy of Sciences of the United States of America. 111: 930-5. PMID 24395803 DOI: 10.1073/Pnas.1316312111  0.79
2014 Mitchell MJ, King MR. Physical biology in cancer. 3. The role of cell glycocalyx in vascular transport of circulating tumor cells. American Journal of Physiology. Cell Physiology. 306: C89-97. PMID 24133067 DOI: 10.1152/Ajpcell.00285.2013  0.488
2013 Mitchell MJ, King MR. Fluid Shear Stress Sensitizes Cancer Cells to Receptor-Mediated Apoptosis via Trimeric Death Receptors. New Journal of Physics. 15: 015008. PMID 25110459 DOI: 10.1088/1367-2630/15/1/015008  0.463
2013 Cao TM, Mitchell MJ, Liesveld J, King MR. Stem cell enrichment with selectin receptors: mimicking the pH environment of trauma. Sensors (Basel, Switzerland). 13: 12516-26. PMID 24048341 DOI: 10.3390/S130912516  0.455
2013 Mitchell MJ, King MR. Computational and experimental models of cancer cell response to fluid shear stress. Frontiers in Oncology. 3: 44. PMID 23467856 DOI: 10.3389/Fonc.2013.00044  0.459
2013 Mitchell MJ, King MR. Computational and experimental models of cancer cell response to fluid shear stress Frontiers in Oncology. 3. DOI: 10.3389/fonc.2013.00044  0.384
2013 Mitchell MJ, King MR. Fluid shear stress sensitizes cancer cells to receptor-mediated apoptosis via trimeric death receptors New Journal of Physics. 15. DOI: 10.1088/1367-2630/15/1/015008  0.389
2012 Mitchell MJ, Castellanos CA, King MR. Nanostructured Surfaces to Target and Kill Circulating Tumor Cells While Repelling Leukocytes. Journal of Nanomaterials. 2012. PMID 25152752 DOI: 10.1155/2012/831263  0.514
2012 Mitchell MJ, King MR. Shear-induced resistance to neutrophil activation via the formyl peptide receptor. Biophysical Journal. 102: 1804-14. PMID 22768936 DOI: 10.1016/j.bpj.2012.03.053  0.331
2012 Mitchell MJ, Chen CS, Ponmudi V, Hughes AD, King MR. E-selectin liposomal and nanotube-targeted delivery of doxorubicin to circulating tumor cells. Journal of Controlled Release : Official Journal of the Controlled Release Society. 160: 609-17. PMID 22421423 DOI: 10.1016/J.Jconrel.2012.02.018  0.67
2011 Mitchell MJ, King MR. Shear-induced resistance to neutrophil activation via the formyl peptide receptor 2011 Ieee 37th Annual Northeast Bioengineering Conference, Nebec 2011. DOI: 10.1109/NEBC.2011.5778708  0.328
2008 Ehrmann I, Dalgliesh C, Tsaousi A, Paronetto MP, Heinrich B, Kist R, Cairns P, Li W, Mueller C, Jackson M, Peters H, Nayernia K, Saunders P, Mitchell M, Stamm S, et al. Haploinsufficiency of the germ cell-specific nuclear RNA binding protein hnRNP G-T prevents functional spermatogenesis in the mouse. Human Molecular Genetics. 17: 2803-18. PMID 18562473 DOI: 10.1093/Hmg/Ddn179  0.353
1999 Sargent CA, Boucher CA, Kirsch S, Brown G, Weiss B, Trundley A, Burgoyne P, Saut N, Durand C, Levy N, Terriou P, Hargreave T, Cooke H, Mitchell M, Rappold GA, et al. The critical region of overlap defining the AZFa male infertility interval of proximal Yq contains three transcribed sequences. Journal of Medical Genetics. 36: 670-677. DOI: 10.1136/Jmg.36.9.670  0.316
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