Scott Q. Harper, PhD - Publications

Pediatrics and Center for Gene Therapy The Ohio State University and Nationwide Children's Hospital 
muscle gene therapy, RNAi, FSHD, LGMD1A, DMD

38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Ansseau E, Eidahl JO, Lancelot C, Tassin A, Matteotti C, Yip C, Liu J, Leroy B, Hubeau C, Gerbaux C, Cloet S, Wauters A, Zorbo S, Meyer P, Pirson I, ... ... Harper SQ, et al. Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation. Plos One. 11: e0146893. PMID 26816005 DOI: 10.1371/Journal.Pone.0146893  0.88
2015 Ansseau E, Domire JS, Wallace LM, Eidahl JO, Guckes SM, Giesige CR, Pyne NK, Belayew A, Harper SQ. Aberrant splicing in transgenes containing introns, exons, and V5 epitopes: lessons from developing an FSHD mouse model expressing a D4Z4 repeat with flanking genomic sequences. Plos One. 10: e0118813. PMID 25742305 DOI: 10.1371/Journal.Pone.0118813  0.88
2014 Liu J, Wallace LM, Garwick-Coppens SE, Sloboda DD, Davis CS, Hakim CH, Hauser MA, Brooks SV, Mendell JR, Harper SQ. RNAi-mediated Gene Silencing of Mutant Myotilin Improves Myopathy in LGMD1A Mice. Molecular Therapy. Nucleic Acids. 3: e160. PMID 24781192 DOI: 10.1038/Mtna.2014.13  0.88
2014 O'Reilly M, Federoff HJ, Fong Y, Kohn DB, Patterson AP, Ahmed N, Asokan A, Boye SE, Crystal RG, De Oliveira S, Gargiulo L, Harper SQ, Ikeda Y, Jambou R, Montgomery M, et al. Gene therapy: charting a future course--summary of a National Institutes of Health Workshop, April 12, 2013. Human Gene Therapy. 25: 488-97. PMID 24773122 DOI: 10.1089/Hum.2014.045  0.88
2013 Wallace LM, Moreo A, Clark KR, Harper SQ. Dose-dependent Toxicity of Humanized Renilla reniformis GFP (hrGFP) Limits Its Utility as a Reporter Gene in Mouse Muscle. Molecular Therapy. Nucleic Acids. 2: e86. PMID 23591809 DOI: 10.1038/Mtna.2013.16  0.88
2013 Harper SQ. Molecular dissection of dystrophin identifies the docking site for nNOS. Proceedings of the National Academy of Sciences of the United States of America. 110: 387-8. PMID 23277550 DOI: 10.1073/Pnas.1220256110  0.88
2012 Liu J, Harper SQ. RNAi-based gene therapy for dominant Limb Girdle Muscular Dystrophies. Current Gene Therapy. 12: 307-14. PMID 22856606 DOI: 10.2174/156652312802083585  0.88
2012 Wallace LM, Liu J, Domire JS, Garwick-Coppens SE, Guckes SM, Mendell JR, Flanigan KM, Harper SQ. RNA interference inhibits DUX4-induced muscle toxicity in vivo: implications for a targeted FSHD therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 1417-23. PMID 22508491 DOI: 10.1038/Mt.2012.68  0.88
2011 Garwick-Coppens SE, Herman A, Harper SQ. Construction of permanently inducible miRNA-based expression vectors using site-specific recombinases. Bmc Biotechnology. 11: 107. PMID 22087765 DOI: 10.1186/1472-6750-11-107  0.88
2011 Wallace LM, Garwick-Coppens SE, Tupler R, Harper SQ. RNA interference improves myopathic phenotypes in mice over-expressing FSHD region gene 1 (FRG1). Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 2048-54. PMID 21730972 DOI: 10.1038/Mt.2011.118  0.88
2011 Wallace LM, Garwick SE, Mei W, Belayew A, Coppee F, Ladner KJ, Guttridge D, Yang J, Harper SQ. DUX4, a candidate gene for facioscapulohumeral muscular dystrophy, causes p53-dependent myopathy in vivo. Annals of Neurology. 69: 540-52. PMID 21446026 DOI: 10.1002/Ana.22275  0.88
2011 Boudreau RL, Garwick-Coppens SE, Liu J, Wallace LM, Harper SQ. Rapid cloning and validation of MicroRNA shuttle vectors: A practical guide Neuromethods. 58: 19-37. DOI: 10.1007/978-1-61779-114-7_2  0.88
2011 Harper SQ. Neuromethods: Preface Neuromethods. 58: vii.  0.88
2010 Jin Z, Wallace L, Harper SQ, Yang J. PP2A:B56{epsilon}, a substrate of caspase-3, regulates p53-dependent and p53-independent apoptosis during development. The Journal of Biological Chemistry. 285: 34493-502. PMID 20807766 DOI: 10.1074/Jbc.M110.169581  0.88
2010 Wallace LM, Garwick SE, Harper SQ. RNAi therapy for dominant muscular dystrophies and other myopathies Muscle Gene Therapy. 99-115. DOI: 10.1007/978-1-4419-1207-7_7  0.88
2009 Blankinship MJ, Gregorevic P, Allen JM, Harper SQ, Harper H, Halbert CL, Miller AD, Chamberlain JS. Erratum to "Efficient Transduction of Skeletal Muscle Using Vectors Based on Adeno-associated Virus Serotype 6". Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 1482. PMID 28160909 DOI: 10.1038/Mt.2009.135  0.4
2009 Harper SQ. Progress and challenges in RNA interference therapy for Huntington disease. Archives of Neurology. 66: 933-8. PMID 19667213 DOI: 10.1001/Archneurol.2009.180  0.88
2008 Packer AN, Xing Y, Harper SQ, Jones L, Davidson BL. The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 14341-6. PMID 19118166 DOI: 10.1523/Jneurosci.2390-08.2008  0.88
2008 McBride JL, Boudreau RL, Harper SQ, Staber PD, Monteys AM, Martins I, Gilmore BL, Burstein H, Peluso RW, Polisky B, Carter BJ, Davidson BL. Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi. Proceedings of the National Academy of Sciences of the United States of America. 105: 5868-73. PMID 18398004 DOI: 10.1073/Pnas.0801775105  0.88
2008 Harper SQ, Gonzalez-Alegre P. Lentivirus-mediated RNA interference in mammalian neurons. Methods in Molecular Biology (Clifton, N.J.). 442: 95-112. PMID 18369781 DOI: 10.1007/978-1-59745-191-8_8  0.88
2006 Allaire PD, Ritter B, Thomas S, Burman JL, Denisov AY, Legendre-Guillemin V, Harper SQ, Davidson BL, Gehring K, McPherson PS. Connecdenn, a novel DENN domain-containing protein of neuronal clathrin-coated vesicles functioning in synaptic vesicle endocytosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 13202-12. PMID 17182770 DOI: 10.1523/Jneurosci.4608-06.2006  0.88
2006 Harper SQ, Staber PD, Beck CR, Fineberg SK, Stein C, Ochoa D, Davidson BL. Optimization of feline immunodeficiency virus vectors for RNA interference. Journal of Virology. 80: 9371-80. PMID 16973543 DOI: 10.1128/Jvi.00958-06  0.88
2006 Staber PD, Vargeese C, Martins IH, Polisky B, Mas-Monteys A, Harper SQ, Davidson BL. 88. Synthetic siRNAs for Huntington's Disease Therapy Molecular Therapy. 13. DOI: 10.1016/J.Ymthe.2006.08.106  0.56
2005 Miller VM, Nelson RF, Gouvion CM, Williams A, Rodriguez-Lebron E, Harper SQ, Davidson BL, Rebagliati MR, Paulson HL. CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 9152-61. PMID 16207874 DOI: 10.1523/Jneurosci.3001-05.2005  0.88
2005 Harper SQ, Davidson BL. Plasmid-based RNA interference: construction of small-hairpin RNA expression vectors. Methods in Molecular Biology (Clifton, N.J.). 309: 219-35. PMID 15990403 DOI: 10.1385/1-59259-935-4:219  0.88
2005 Harper SQ, Staber PD, He X, Eliason SL, Martins IH, Mao Q, Yang L, Kotin RM, Paulson HL, Davidson BL. RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model. Proceedings of the National Academy of Sciences of the United States of America. 102: 5820-5. PMID 15811941 DOI: 10.1073/Pnas.0501507102  0.88
2005 Liu M, Yue Y, Harper SQ, Grange RW, Chamberlain JS, Duan D. Adeno-associated virus-mediated microdystrophin expression protects young mdx muscle from contraction-induced injury. Molecular Therapy : the Journal of the American Society of Gene Therapy. 11: 245-56. PMID 15668136 DOI: 10.1016/J.Ymthe.2004.09.013  0.88
2005 Davidson BL, Harper SQ. Viral delivery of recombinant short hairpin RNAs. Methods in Enzymology. 392: 145-73. PMID 15644180 DOI: 10.1016/S0076-6879(04)92009-5  0.88
2005 Harper SQ, Staber PD, He X, Martins IH, Mao Q, Paulson HL, Kotin RM, Davidson BL. 52. AAV-Delivered RNAi Improves Cellular and Motor Phenotypes in a Mouse Model for Huntington's Disease Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.080  0.56
2004 Blankinship MJ, Gregorevic P, Allen JM, Harper SQ, Harper H, Halbert CL, Miller AD, Miller DA, Chamberlain JS. Efficient transduction of skeletal muscle using vectors based on adeno-associated virus serotype 6. Molecular Therapy : the Journal of the American Society of Gene Therapy. 10: 671-8. PMID 15451451 DOI: 10.1016/J.Ymthe.2004.07.016  0.88
2004 Xia H, Mao Q, Eliason SL, Harper SQ, Martins IH, Orr HT, Paulson HL, Yang L, Kotin RM, Davidson BL. RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia. Nature Medicine. 10: 816-20. PMID 15235598 DOI: 10.1038/Nm1076  0.88
2004 Xia H, Mao Q, Eliason SL, Kiewiet N, Critchfield J, Martins IH, Harper SQ, He X, Kotin RM, Zoghbi HY, Orr HT, Paulson HL, Davidson BL. 717. RNAi Therapy for Dominant Neurodegenerative Diseases Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.623  0.56
2004 Harper SQ, Staber PD, Rowley CR, He X, Martins IH, Mao Q, Paulson HL, Davidson BL. 209. Gene Silencing of Human Huntingtin Using Lentivirus-Delivered shRNA Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.150  0.56
2003 Yue Y, Li Z, Harper SQ, Davisson RL, Chamberlain JS, Duan D. Microdystrophin gene therapy of cardiomyopathy restores dystrophin-glycoprotein complex and improves sarcolemma integrity in the mdx mouse heart. Circulation. 108: 1626-32. PMID 12952841 DOI: 10.1161/01.Cir.0000089371.11664.27  0.88
2002 Scott JM, Li S, Harper SQ, Welikson R, Bourque D, DelloRusso C, Hauschka SD, Chamberlain JS. Viral vectors for gene transfer of micro-, mini-, or full-length dystrophin. Neuromuscular Disorders : Nmd. 12: S23-9. PMID 12206791 DOI: 10.1016/S0960-8966(02)00078-0  0.88
2002 Harper SQ, Crawford RW, DelloRusso C, Chamberlain JS. Spectrin-like repeats from dystrophin and alpha-actinin-2 are not functionally interchangeable. Human Molecular Genetics. 11: 1807-15. PMID 12140183 DOI: 10.1093/Hmg/11.16.1807  0.88
2002 Harper SQ, Hauser MA, DelloRusso C, Duan D, Crawford RW, Phelps SF, Harper HA, Robinson AS, Engelhardt JF, Brooks SV, Chamberlain JS. Modular flexibility of dystrophin: implications for gene therapy of Duchenne muscular dystrophy. Nature Medicine. 8: 253-61. PMID 11875496 DOI: 10.1038/Nm0302-253  0.88
1998 Han CD, Chun SB, Hahn SF, Harper SQ, Savickas PJ, Meunier DM, Li L, Yalcin T. Phase behavior of polystyrene/polybutadiene and polystyrene/hydrogenated polybutadiene mixtures: Effect of the microstructure of polybutadiene Macromolecules. 31: 394-402. DOI: 10.1021/Ma971309E  0.88
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