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Leah Caroline Thomas Byrne, Ph.D. - Publications

Affiliations: 
School of Veterinary Medicine, Ophthalmology University of Pennsylvania, Philadelphia, PA, United States 
Area:
Viral gene therapy, retinal degeneration
Website:
http://www.cchem.berkeley.edu/schaffer/leah.html

24 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Aweidah H, Xi Z, Sahel JA, Byrne LC. PRPF31-retinitis pigmentosa: Challenges and opportunities for clinical translation. Vision Research. 213: 108315. PMID 37714045 DOI: 10.1016/j.visres.2023.108315  0.535
2023 Zin EA, Ozturk BE, Dalkara D, Byrne LC. Developing New Vectors for Retinal Gene Therapy. Cold Spring Harbor Perspectives in Medicine. PMID 36987583 DOI: 10.1101/cshperspect.a041291  0.716
2022 Xi Z, Vats A, Sahel JA, Chen Y, Byrne LC. Gene augmentation prevents retinal degeneration in a CRISPR/Cas9-based mouse model of PRPF31 retinitis pigmentosa. Nature Communications. 13: 7695. PMID 36509783 DOI: 10.1038/s41467-022-35361-8  0.613
2022 Rodrigues A, Slembrouck-Brec A, Nanteau C, Terray A, Tymoshenko Y, Zagar Y, Reichman S, Xi Z, Sahel JA, Fouquet S, Orieux G, Nandrot EF, Byrne LC, Audo I, Roger JE, et al. Modeling PRPF31 retinitis pigmentosa using retinal pigment epithelium and organoids combined with gene augmentation rescue. Npj Regenerative Medicine. 7: 39. PMID 35974011 DOI: 10.1038/s41536-022-00235-6  0.558
2022 Xi Z, Öztürk BE, Johnson ME, Turunç S, Stauffer WR, Byrne LC. Quantitative single-cell transcriptome-based ranking of engineered AAVs in human retinal explants. Molecular Therapy. Methods & Clinical Development. 25: 476-489. PMID 35615708 DOI: 10.1016/j.omtm.2022.04.014  0.589
2022 Miyadera K, Santana E, Roszak K, Iffrig S, Visel M, Iwabe S, Boyd RF, Bartoe JT, Sato Y, Gray A, Ripolles-Garcia A, Dufour VL, Byrne LC, Flannery JG, Beltran WA, et al. Targeting ON-bipolar cells by AAV gene therapy stably reverses -congenital stationary night blindness. Proceedings of the National Academy of Sciences of the United States of America. 119: e2117038119. PMID 35316139 DOI: 10.1073/pnas.2117038119  0.69
2021 Öztürk BE, Johnson ME, Kleyman M, Turunç S, He J, Jabalameli S, Xi Z, Visel M, Dufour VL, Iwabe S, Pompeo Marinho F, Aguirre GD, Sahel JA, Schaffer DV, Pfenning AR, ... ... Byrne LC, et al. scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution. Elife. 10. PMID 34664552 DOI: 10.7554/eLife.64175  0.634
2021 Gemayel M, Byrne LC, Ciulla T, Sahel JA. Delivery of Genetic Information: Viral Vector and Nonviral Vector Gene Therapies. International Ophthalmology Clinics. 61: 35-57. PMID 34196317 DOI: 10.1097/IIO.0000000000000360  0.313
2020 Liu X, Feng B, Vats A, Tang H, Seibel W, Swaroop M, Tawa G, Zheng W, Byrne L, Schurdak M, Chen Y. Pharmacological clearance of misfolded rhodopsin for the treatment of RHO-associated retinitis pigmentosa. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32536017 DOI: 10.1096/Fj.202000282R  0.491
2020 Byrne LC, Day TP, Visel M, Fortuny C, Dalkara D, Merigan WH, Schaffer DV, Flannery JG. In vivo directed evolution of AAV in the primate retina. Jci Insight. PMID 32271719 DOI: 10.1172/Jci.Insight.135112  0.784
2018 Day TP, Byrne LC, Flannery JG, Schaffer DV. Screening for Neutralizing Antibodies Against Natural and Engineered AAV Capsids in Nonhuman Primate Retinas. Methods in Molecular Biology (Clifton, N.J.). 1715: 239-249. PMID 29188518 DOI: 10.1007/978-1-4939-7522-8_17  0.687
2017 Byrne L. Rounding up sickle cells with gene therapy. Science Translational Medicine. 9. PMID 28298423 DOI: 10.1126/Scitranslmed.Aam9864  0.436
2015 Shen SQ, Myers CA, Hughes AE, Byrne LC, Flannery JG, Corbo JC. Massively parallel cis-regulatory analysis in the mammalian central nervous system. Genome Research. PMID 26576614 DOI: 10.1101/Gr.193789.115  0.572
2015 Aït-Ali N, Fridlich R, Millet-Puel G, Clérin E, Delalande F, Jaillard C, Blond F, Perrocheau L, Reichman S, Byrne LC, Olivier-Bandini A, Bellalou J, Moyse E, Bouillaud F, Nicol X, et al. Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis. Cell. 161: 817-32. PMID 25957687 DOI: 10.1016/J.Cell.2015.03.023  0.625
2015 Xue Y, Shen SQ, Jui J, Rupp AC, Byrne LC, Hattar S, Flannery JG, Corbo JC, Kefalov VJ. CRALBP supports the mammalian retinal visual cycle and cone vision. The Journal of Clinical Investigation. 125: 727-38. PMID 25607845 DOI: 10.1172/Jci79651  0.66
2015 Byrne LC, Dalkara D, Luna G, Fisher SK, Clérin E, Sahel JA, Léveillard T, Flannery JG. Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration. The Journal of Clinical Investigation. 125: 105-16. PMID 25415434 DOI: 10.1172/Jci65654  0.777
2015 Byrne LC, Lin YJ, Lee T, Schaffer DV, Flannery JG. The expression pattern of systemically injected AAV9 in the developing mouse retina is determined by age. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 290-6. PMID 25224467 DOI: 10.1038/Mt.2014.181  0.716
2015 Aït-Ali N, Fridlich R, Millet-Puel G, Clérin E, Delalande F, Jaillard C, Blond F, Perrocheau L, Reichman S, Byrne LC, Olivier-Bandini A, Bellalou J, Moyse E, Bouillaud F, Nicol X, et al. Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis Cell. 161: 817-832. DOI: 10.1016/j.cell.2015.03.023  0.57
2014 Byrne LC, Oztürk BE, Lee T, Fortuny C, Visel M, Dalkara D, Schaffer DV, Flannery JG. Retinoschisin gene therapy in photoreceptors, Müller glia or all retinal cells in the Rs1h-/- mouse. Gene Therapy. 21: 585-92. PMID 24694538 DOI: 10.1038/Gt.2014.31  0.799
2014 Day TP, Byrne LC, Schaffer DV, Flannery JG. Advances in AAV vector development for gene therapy in the retina. Advances in Experimental Medicine and Biology. 801: 687-93. PMID 24664759 DOI: 10.1007/978-1-4614-3209-8_86  0.736
2014 Cheong S, Song W, Byrne L, Balasubramanian R, Merigan W. In vivo imaging of ChR2-RCaMP expression in retinal neurons of a transgenic blind mouse model Journal of Vision. 14: 35-35. DOI: 10.1167/14.15.35  0.45
2013 Byrne LC, Khalid F, Lee T, Zin EA, Greenberg KP, Visel M, Schaffer DV, Flannery JG. AAV-mediated, optogenetic ablation of Müller Glia leads to structural and functional changes in the mouse retina. Plos One. 8: e76075. PMID 24086689 DOI: 10.1371/Journal.Pone.0076075  0.771
2013 Dalkara D, Byrne LC, Klimczak RR, Visel M, Yin L, Merigan WH, Flannery JG, Schaffer DV. In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous. Science Translational Medicine. 5: 189ra76. PMID 23761039 DOI: 10.1126/Scitranslmed.3005708  0.738
2012 Dalkara D, Byrne LC, Lee T, Hoffmann NV, Schaffer DV, Flannery JG. Enhanced gene delivery to the neonatal retina through systemic administration of tyrosine-mutated AAV9. Gene Therapy. 19: 176-81. PMID 22011645 DOI: 10.1038/Gt.2011.163  0.798
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