| Year |
Citation |
Score |
| 2024 |
Basheer N, Buee L, Brion JP, Smolek T, Muhammadi MK, Hritz J, Hromadka T, Dewachter I, Wegmann S, Landrieu I, Novak P, Mudher A, Zilka N. Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models. Acta Neuropathologica Communications. 12: 52. PMID 38576010 DOI: 10.1186/s40478-024-01748-5 |
0.517 |
|
| 2023 |
Rodrigues S, Anglada-Huguet M, Hochgräfe K, Kaniyappan S, Wegmann S, Mandelkow EM. Spreading of Tau Protein Does Not Depend on Aggregation Propensity. Journal of Molecular Neuroscience : Mn. PMID 37606769 DOI: 10.1007/s12031-023-02143-w |
0.639 |
|
| 2023 |
Davies C, Tulloch J, Yip E, Currie L, Colom-Cadena M, Wegmann S, Hyman BT, Wilkins L, Hooley M, Tzioras M, Spires-Jones TL. Apolipoprotein E isoform does not influence trans-synaptic spread of tau pathology in a mouse model. Brain and Neuroscience Advances. 7: 23982128231191046. PMID 37600228 DOI: 10.1177/23982128231191046 |
0.779 |
|
| 2023 |
Prince PR, Hochmair J, Brognaro H, Gevorgyan S, Franck M, Schubert R, Lorenzen K, Yazici S, Mandelkow E, Wegmann S, Betzel C. Initiation and modulation of Tau protein phase separation by the drug suramin. Scientific Reports. 13: 3963. PMID 36894559 DOI: 10.1038/s41598-023-29846-9 |
0.699 |
|
| 2022 |
Hochmair J, Exner C, Betzel C, Mandelkow E, Wegmann S. Light Microscopy and Dynamic Light Scattering to Study Liquid-Liquid Phase Separation of Tau Proteins In Vitro. Methods in Molecular Biology (Clifton, N.J.). 2551: 225-243. PMID 36310206 DOI: 10.1007/978-1-0716-2597-2_15 |
0.687 |
|
| 2022 |
Diez L, Kapinos LE, Lim RYH, Wegmann S. Analysis of Tau/Nucleoporin Interactions by Surface Plasmon Resonance Spectroscopy. Methods in Molecular Biology (Clifton, N.J.). 2551: 95-109. PMID 36310199 DOI: 10.1007/978-1-0716-2597-2_8 |
0.407 |
|
| 2022 |
Diez L, Kapinos LE, Hochmair J, Huebschmann S, Dominguez-Baquero A, Vogt A, Rankovic M, Zweckstetter M, Lim RYH, Wegmann S. Phosphorylation but Not Oligomerization Drives the Accumulation of Tau with Nucleoporin Nup98. International Journal of Molecular Sciences. 23. PMID 35408855 DOI: 10.3390/ijms23073495 |
0.595 |
|
| 2022 |
Hochmair J, Exner C, Franck M, Dominguez-Baquero A, Diez L, Brognaro H, Kraushar ML, Mielke T, Radbruch H, Kaniyappan S, Falke S, Mandelkow E, Betzel C, Wegmann S. Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates. The Embo Journal. e108882. PMID 35298090 DOI: 10.15252/embj.2021108882 |
0.678 |
|
| 2021 |
Wegmann S, Biernat J, Mandelkow E. A current view on Tau protein phosphorylation in Alzheimer's disease. Current Opinion in Neurobiology. 69: 131-138. PMID 33892381 DOI: 10.1016/j.conb.2021.03.003 |
0.735 |
|
| 2021 |
Caballero B, Bourdenx M, Luengo E, Diaz A, Sohn PD, Chen X, Wang C, Juste YR, Wegmann S, Patel B, Young ZT, Kuo SY, Rodriguez-Navarro JA, Shao H, Lopez MG, et al. Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice. Nature Communications. 12: 2238. PMID 33854069 DOI: 10.1038/s41467-021-22501-9 |
0.69 |
|
| 2021 |
Wegmann S, DeVos SL, Zeitler B, Marlen K, Bennett RE, Perez-Rando M, MacKenzie D, Yu Q, Commins C, Bannon RN, Corjuc BT, Chase A, Diez L, Nguyen HB, Hinkley S, et al. Persistent repression of tau in the brain using engineered zinc finger protein transcription factors. Science Advances. 7. PMID 33741591 DOI: 10.1126/sciadv.abe1611 |
0.794 |
|
| 2021 |
Ash PEA, Lei S, Shattuck J, Boudeau S, Carlomagno Y, Medalla M, Mashimo BL, Socorro G, Al-Mohanna LFA, Jiang L, Öztürk MM, Knobel M, Ivanov P, Petrucelli L, Wegmann S, et al. TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33619090 DOI: 10.1073/pnas.2014188118 |
0.498 |
|
| 2021 |
Amaral AC, Perez-Nievas BG, Siao Tick Chong M, Gonzalez-Martinez A, Argente-Escrig H, Rubio-Guerra S, Commins C, Muftu S, Eftekharzadeh B, Hudry E, Fan Z, Ramanan P, Takeda S, Frosch MP, Wegmann S, et al. Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3β) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation. Iscience. 24: 102058. PMID 33554064 DOI: 10.1016/j.isci.2021.102058 |
0.494 |
|
| 2020 |
Diez L, Wegmann S. Nuclear Transport Deficits in Tau-Related Neurodegenerative Diseases. Frontiers in Neurology. 11: 1056. PMID 33101165 DOI: 10.3389/fneur.2020.01056 |
0.485 |
|
| 2020 |
Rauch JN, Luna G, Guzman E, Audouard M, Challis C, Sibih YE, Leshuk C, Hernandez I, Wegmann S, Hyman BT, Gradinaru V, Kampmann M, Kosik KS. LRP1 is a master regulator of tau uptake and spread. Nature. 580: 381-385. PMID 32296178 DOI: 10.1038/S41586-020-2156-5 |
0.713 |
|
| 2019 |
Wegmann S. Liquid-Liquid Phase Separation of Tau Protein in Neurobiology and Pathology. Advances in Experimental Medicine and Biology. 1184: 341-357. PMID 32096048 DOI: 10.1007/978-981-32-9358-8_25 |
0.484 |
|
| 2019 |
Ukmar-Godec T, Wegmann S, Zweckstetter M. Biomolecular condensation of the microtubule-associated protein tau. Seminars in Cell & Developmental Biology. PMID 31260737 DOI: 10.1016/j.semcdb.2019.06.007 |
0.416 |
|
| 2019 |
Wegmann S, Bennett RE, Delorme L, Robbins AB, Hu M, McKenzie D, Kirk MJ, Schiantarelli J, Tunio N, Amaral AC, Fan Z, Nicholls S, Hudry E, Hyman BT. Experimental evidence for the age dependence of tau protein spread in the brain. Science Advances. 5: eaaw6404. PMID 31249873 DOI: 10.1126/Sciadv.Aaw6404 |
0.791 |
|
| 2019 |
Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, ... ... Wegmann S, et al. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 101: 349. PMID 30653936 DOI: 10.1016/J.Neuron.2018.12.031 |
0.802 |
|
| 2019 |
Busche MA, Wegmann S, Dujardin S, Commins C, Schiantarelli J, Klickstein N, Kamath TV, Carlson GA, Nelken I, Hyman BT. Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo. Nature Neuroscience. 22: 57-64. PMID 30559471 DOI: 10.1038/S41593-018-0289-8 |
0.823 |
|
| 2018 |
Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburgh CR, ... ... Wegmann S, et al. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 99: 925-940.e7. PMID 30189209 DOI: 10.1016/J.Neuron.2018.07.039 |
0.849 |
|
| 2018 |
Kara E, Marks JD, Roe AD, Commins C, Fan Z, Calvo-Rodriguez M, Wegmann S, Hudry E, Hyman BT. A flow cytometry-based in vitro assay reveals that formation of apolipoprotein E (ApoE)-amyloid beta complexes depends on ApoE isoform- and cell type. The Journal of Biological Chemistry. PMID 29950521 DOI: 10.1074/Jbc.Ra117.001388 |
0.563 |
|
| 2018 |
Mari SA, Wegmann S, Tepper K, Hyman BT, Mandelkow EM, Mandelkow E, Müller DJ. Reversible Cation-Selective Attachment and Self-Assembly of Human Tau on Supported Brain Lipid Membranes. Nano Letters. PMID 29644863 DOI: 10.1021/Acs.Nanolett.8B01085 |
0.661 |
|
| 2018 |
Wegmann S, Eftekharzadeh B, Tepper K, Zoltowska KM, Bennett RE, Dujardin S, Laskowski PR, MacKenzie D, Kamath T, Commins C, Vanderburg C, Roe AD, Fan Z, Molliex AM, Hernandez-Vega A, et al. Tau protein liquid-liquid phase separation can initiate tau aggregation. The Embo Journal. PMID 29472250 DOI: 10.15252/Embj.201798049 |
0.832 |
|
| 2017 |
Sotiropoulos I, Galas MC, Silva JM, Skoulakis E, Wegmann S, Maina MB, Blum D, Sayas CL, Mandelkow EM, Mandelkow E, Spillantini MG, Sousa N, Avila J, Medina M, Mudher A, et al. Atypical, non-standard functions of the microtubule associated Tau protein. Acta Neuropathologica Communications. 5: 91. PMID 29187252 DOI: 10.1186/S40478-017-0489-6 |
0.721 |
|
| 2017 |
Wegmann S, Bennett RE, Amaral AS, Hyman BT. Studying tau protein propagation and pathology in the mouse brain using adeno-associated viruses. Methods in Cell Biology. 141: 307-322. PMID 28882310 DOI: 10.1016/Bs.Mcb.2017.06.014 |
0.802 |
|
| 2017 |
Hernández-Vega A, Braun M, Scharrel L, Jahnel M, Wegmann S, Hyman BT, Alberti S, Diez S, Hyman AA. Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase. Cell Reports. 20: 2304-2312. PMID 28877466 DOI: 10.1016/j.celrep.2017.08.042 |
0.546 |
|
| 2017 |
Kara E, Marks JD, Fan Z, Klickstein JA, Roe AD, Krogh KA, Wegmann S, Maesako M, Luo CC, Mylvaganam R, Berezovska O, Hudry E, Hyman BT. Isoform and cell type-specific structure of Apolipoprotein E lipoparticles as revealed by a novel Forster Resonance Energy Transfer assay. The Journal of Biological Chemistry. PMID 28684412 DOI: 10.1074/Jbc.M117.784264 |
0.709 |
|
| 2017 |
Nicholls SB, DeVos SL, Commins C, Nobuhara C, Bennett RE, Corjuc DL, Maury E, Eftekharzadeh B, Akingbade O, Fan Z, Roe AD, Takeda S, Wegmann S, Hyman BT. Characterization of TauC3 antibody and demonstration of its potential to block tau propagation. Plos One. 12: e0177914. PMID 28531180 DOI: 10.1371/Journal.Pone.0177914 |
0.795 |
|
| 2017 |
Nobuhara CK, DeVos SL, Commins C, Wegmann S, Moore BD, Roe AD, Costantino I, Frosch MP, Pitstick R, Carlson GA, Hock C, Nitsch RM, Montrasio F, Grimm J, Cheung AE, et al. Tau Antibody-Targeting Pathological Species Block Neuronal Uptake and Interneuron Propagation of Tau in Vitro. The American Journal of Pathology. PMID 28408124 DOI: 10.1016/J.Ajpath.2017.01.022 |
0.668 |
|
| 2017 |
Pickett EK, Henstridge CM, Allison E, Pitstick R, Pooler A, Wegmann S, Carlson G, Hyman BT, Spires-Jones TL. Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease. Synapse (New York, N.Y.). PMID 28196395 DOI: 10.1002/Syn.21965 |
0.739 |
|
| 2017 |
Kastanenka KV, Hou SS, Shakerdge N, Logan R, Feng D, Wegmann S, Chopra V, Hawkes JM, Chen X, Bacskai BJ. Optogenetic Restoration of Disrupted Slow Oscillations Halts Amyloid Deposition and Restores Calcium Homeostasis in an Animal Model of Alzheimer's Disease. Plos One. 12: e0170275. PMID 28114405 DOI: 10.1371/Journal.Pone.0170275 |
0.37 |
|
| 2016 |
Jackson RJ, Rudinskiy N, Herrmann AG, Croft S, Kim JM, Petrova V, Ramos-Rodriguez JJ, Pitstick R, Wegmann S, Garcia-Alloza M, Carlson GA, Hyman BT, Spires-Jones TL. Human tau increases amyloid β plaque size but not amyloid β-mediated synapse loss in a novel mouse model of Alzheimer's disease. The European Journal of Neuroscience. PMID 27748574 DOI: 10.1111/Ejn.13442 |
0.765 |
|
| 2016 |
Wegmann S, Nicholls S, Takeda S, Fan Z, Hyman BT. Formation, release, and internalization of stable tau oligomers in cells. Journal of Neurochemistry. PMID 27731899 DOI: 10.1111/Jnc.13866 |
0.702 |
|
| 2016 |
Fu H, Hussaini SA, Wegmann S, Profaci C, Daniels JD, Herman M, Emrani S, Figueroa HY, Hyman BT, Davies P, Duff KE. 3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice. Plos One. 11: e0159463. PMID 27466814 DOI: 10.1371/Journal.Pone.0159463 |
0.713 |
|
| 2016 |
Takeda S, Commins C, DeVos SL, Nobuhara CK, Wegmann S, Roe AD, Costantino I, Fan Z, Nicholls SB, Sherman AE, Trisini Lipsanopoulos AT, Scherzer CR, Carlson GA, Pitstick R, Peskind ER, et al. Seed-competent HMW tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients. Annals of Neurology. PMID 27351289 DOI: 10.1002/Ana.24716 |
0.663 |
|
| 2016 |
Pickett EK, Koffie RM, Wegmann S, Henstridge CM, Herrmann AG, Colom-Cadena M, Lleo A, Kay KR, Vaught M, Soberman R, Walsh DM, Hyman BT, Spires-Jones TL. Non-Fibrillar Oligomeric Amyloid-β within Synapses. Journal of Alzheimer's Disease : Jad. PMID 27258414 DOI: 10.3233/Jad-160007 |
0.722 |
|
| 2016 |
Eftekharzadeh B, Hyman BT, Wegmann S. Structural studies on the mechanism of protein aggregation in age related neurodegenerative diseases. Mechanisms of Ageing and Development. 156: 1-13. PMID 27005270 DOI: 10.1016/J.Mad.2016.03.001 |
0.479 |
|
| 2016 |
Pickett E, Henstridge C, Jackson RJ, Herrmann AG, Wegmann S, Hyman BT, Carlson GA, Spires-Jones TL. EC-03-03: Tau Spreading and Toxicity Alzheimer's & Dementia. 12: P269-P269. DOI: 10.1016/J.Jalz.2016.06.2381 |
0.729 |
|
| 2015 |
Wegmann S, Maury EA, Kirk MJ, Saqran L, Roe A, DeVos SL, Nicholls S, Fan Z, Takeda S, Cagsal-Getkin O, William CM, Spires-Jones TL, Pitstick R, Carlson GA, Pooler AM, et al. Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity. The Embo Journal. PMID 26538322 DOI: 10.15252/Embj.201592748 |
0.808 |
|
| 2015 |
Takeda S, Wegmann S, Cho H, DeVos SL, Commins C, Roe AD, Nicholls SB, Carlson GA, Pitstick R, Nobuhara CK, Costantino I, Frosch MP, Müller DJ, Irimia D, Hyman BT. Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain. Nature Communications. 6: 8490. PMID 26458742 DOI: 10.1038/Ncomms9490 |
0.701 |
|
| 2015 |
Pooler AM, Polydoro M, Maury EA, Nicholls SB, Reddy SM, Wegmann S, William C, Saqran L, Cagsal-Getkin O, Pitstick R, Beier DR, Carlson GA, Spires-Jones TL, Hyman BT. Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease. Acta Neuropathologica Communications. 3: 14. PMID 25853174 DOI: 10.1186/S40478-015-0199-X |
0.829 |
|
| 2015 |
Hori Y, Takeda S, Cho H, Wegmann S, Shoup TM, Takahashi K, Irimia D, Elmaleh DR, Hyman BT, Hudry E. A Food and Drug Administration-approved asthma therapeutic agent impacts amyloid β in the brain in a transgenic model of Alzheimer disease. The Journal of Biological Chemistry. 290: 1966-78. PMID 25468905 DOI: 10.1074/Jbc.M114.586602 |
0.544 |
|
| 2015 |
Wegmann S, Maury EA, Kirk MJ, Saqran L, Roe AD, Fan Z, Nicholls SB, DeVos SL, Takeda S, William CM, Spires-Jones TL, Pitstick R, Carlson GA, Pooler A, Hyman BT. O2-06-01: Lack of endogenous tau permits tau spreading and protects against tau toxicity in transgenic mice Alzheimer's & Dementia. 11: P186-P186. DOI: 10.1016/J.Jalz.2015.07.159 |
0.729 |
|
| 2015 |
Takeda S, Commins C, Wegmann S, Roe AD, Fan Z, DeVos SL, Costantino I, Trisini Lipsanopoulos A, Frosch MP, Hyman BT. P3-071: A unique high-molecular-weight tau species is involved in propagation and accumulates in the cerebrospinal fluid of Alzheimer's disease patients Alzheimer's & Dementia. 11: P644-P644. DOI: 10.1016/J.Jalz.2015.06.938 |
0.532 |
|
| 2014 |
Tepper K, Biernat J, Kumar S, Wegmann S, Timm T, Hübschmann S, Redecke L, Mandelkow EM, Müller DJ, Mandelkow E. Oligomer formation of tau protein hyperphosphorylated in cells. The Journal of Biological Chemistry. 289: 34389-407. PMID 25339173 DOI: 10.1074/Jbc.M114.611368 |
0.661 |
|
| 2014 |
Rudinskiy N, Hawkes JM, Wegmann S, Kuchibhotla KV, Muzikansky A, Betensky RA, Spires-Jones TL, Hyman BT. Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses. Acta Neuropathologica Communications. 2: 63. PMID 24915991 DOI: 10.1186/2051-5960-2-63 |
0.716 |
|
| 2014 |
Kumar S, Tepper K, Kaniyappan S, Biernat J, Wegmann S, Mandelkow EM, Müller DJ, Mandelkow E. Stages and conformations of the Tau repeat domain during aggregation and its effect on neuronal toxicity. The Journal of Biological Chemistry. 289: 20318-32. PMID 24825901 DOI: 10.1074/Jbc.M114.554725 |
0.633 |
|
| 2014 |
Kuchibhotla KV, Wegmann S, Kopeikina KJ, Hawkes J, Rudinskiy N, Andermann ML, Spires-Jones TL, Bacskai BJ, Hyman BT. Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo. Proceedings of the National Academy of Sciences of the United States of America. 111: 510-4. PMID 24368848 DOI: 10.1073/Pnas.1318807111 |
0.78 |
|
| 2014 |
Hudry E, Kuchibhotla K, Wrobleski L, Wegmann S, Arbel-Ornath M, Hyman B. O4-09-04: UNRAVELING THE ROLE OF APOLIPOPROTEIN E IN AGE- AND ABETA-RELATED NEURONAL DYSFUNCTION Alzheimer's & Dementia. 10: P269-P269. DOI: 10.1016/J.Jalz.2014.04.436 |
0.427 |
|
| 2013 |
Kopeikina KJ, Wegmann S, Pitstick R, Carlson GA, Bacskai BJ, Betensky RA, Hyman BT, Spires-Jones TL. Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy. Plos One. 8: e80834. PMID 24278327 DOI: 10.1371/Journal.Pone.0080834 |
0.712 |
|
| 2013 |
Pooler AM, Polydoro M, Wegmann S, Nicholls SB, Spires-Jones TL, Hyman BT. Propagation of tau pathology in Alzheimer's disease: identification of novel therapeutic targets. Alzheimer's Research & Therapy. 5: 49. PMID 24152385 DOI: 10.1186/Alzrt214 |
0.858 |
|
| 2013 |
Pooler AM, Polydoro M, Wegmann SK, Pitstick R, Kay KR, Sanchez L, Carlson GA, Gomez-Isla T, Albers MW, Spires-Jones TL, Hyman BT. Tau-amyloid interactions in the rTgTauEC model of early Alzheimer's disease suggest amyloid-induced disruption of axonal projections and exacerbated axonal pathology. The Journal of Comparative Neurology. 521: 4236-48. PMID 23839581 DOI: 10.1002/Cne.23411 |
0.825 |
|
| 2013 |
Wegmann S, Medalsy ID, Mandelkow E, Müller DJ. The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush. Proceedings of the National Academy of Sciences of the United States of America. 110: E313-21. PMID 23269837 DOI: 10.1073/Pnas.1212100110 |
0.6 |
|
| 2013 |
Kuchibhotla K, Wegmann S, Spires-Jones T, Bacskai B, Hyman B. O2-01-01: Neurofibrillary tangles remain functionally integrated in cortical networks Alzheimer's & Dementia. 9: P314-P314. DOI: 10.1016/J.Jalz.2013.04.135 |
0.567 |
|
| 2012 |
Wegmann S, Muller DJ, Mandelkow E. Investigating fibrillar aggregates of Tau protein by atomic force microscopy. Methods in Molecular Biology (Clifton, N.J.). 849: 169-83. PMID 22528090 DOI: 10.1007/978-1-61779-551-0_12 |
0.523 |
|
| 2011 |
Wegmann S, Schöler J, Bippes CA, Mandelkow E, Muller DJ. Competing interactions stabilize pro- and anti-aggregant conformations of human Tau. The Journal of Biological Chemistry. 286: 20512-24. PMID 21498513 DOI: 10.1074/Jbc.M111.237875 |
0.619 |
|
| 2010 |
Wegmann S, Jung YJ, Chinnathambi S, Mandelkow EM, Mandelkow E, Muller DJ. Human Tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability. The Journal of Biological Chemistry. 285: 27302-13. PMID 20566652 DOI: 10.1074/Jbc.M110.145318 |
0.592 |
|
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