2002 — 2005 |
Moasser, Bahram (co-PI) [⬀] Kemp, Richard |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Goali: Fixation of Co2 For Use in Radiopharmaceuticals @ University of New Mexico
Dr. Richard Kemp, Department of Chemistry, University of New Mexico, is supported by the Inorganic, Bioinorganic, and Organometallic Chemistry Program of the Chemistry Division for research into the rapid fixation of carbon dioxide into organic molecules. There is a need for C-11 containing compounds for several applications, including positron emission tomography (PET). Due to the short half-life of C-11 rapid incorporation of C-11 carbon dioxide is required if these species are to be obtained. The objective of this research is to develop routes to incorporate C-11 carbon dioxide into organic products in less than one hour. Carbon dioxide is known to slowly insert into subvalent group 14 amides to produce isocyanate and/or carbodiimide. Building on the observation that changes in ligand structure and main group metal can dramatically affect CO2 incorporation rates, low-valent Ge, Sn, and Pb reagents will be prepared with a variety of ligands. Their reaction with carbon dioxide will be studied in order to determine the factors that influence the reaction rate. Group 14 compounds will then be developed into catalysts by using various silylated organic amines as substrates. Finally, related compounds not based on Group 14 bis(amides), which should also react with CO2 to produce isocyanates, will be studied.
In this project, methods will be developed to rapidly incorporate radioactive C-11 into organic molecules. These species are required for several applications including PET. This is a GOALI project that involves collaborative efforts between the University of New Mexico and General Electric Corp. The research includes developing the basic science behind rapid carbon dioxide incorporation. The eventual goal is new industrial preparations of valuable radioactive products. Both graduate and postdoctoral students will gain experience in multitask interdisciplinary objectives as part of a collaboration with industry. It is likely that students from traditionally under-represented groups will participate in this research.
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0.915 |
2004 — 2007 |
Kemp, Richard Baker, R |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Nsf Inorganic Chemistry Workshops, 2004-2006 @ University of New Mexico
Dr. Richard Kemp (PI) of the Department of Chemistry, University of New Mexico, and Dr. R. Thomas Baker (co-PI) are supported by the Inorganic, Bioinorganic and Organometallic Chemistry program of the Division of Chemistry to host the 2004, 2005 and 2006 NSF-sponsored Annual Inorganic Workshops. The purpose of these workshops is to assemble researchers from different geographical areas and broad diversity at different stages of their careers to encourage informal and detailed discussion of in progress investigations. The workshops will focus on emerging ideas, new techniques, and unsolved problems. A group of Scientific Advisors will assist in selecting the participants.
The aim of the proposed workshop is to provide a means for efficient, concentrated communication and discussion of current research ideas, progress, problems, and new opportunities in inorganic chemistry. An effort will be made to involve researchers from interfacial areas to encourage new research initiatives. Areas such as materials science, pharmaceutical chemistry, asymmetric synthesis, industrial catalysis, polymer chemistry, analytical chemistry, biochemistry, spectroscopy, theoretical chemistry, gas phase chemistry, and experimental physical chemistry are but a few where creative breakthroughs might occur by cross fertilization of research approaches.
The NSF Inorganic Chemistry Workshop has been an essential element of U.S. education and communication in Inorganic and Organometallic Chemistry over the last 25 years. The workshops bring together inorganic chemists, particularly younger chemists at the Assistant and Associate Professor levels to give them an occasion to test their ideas. An annual report will be made available to the NSF IBO program and to the community based on input from the participants to provide insight into emerging research areas.
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0.915 |
2005 — 2008 |
Kemp, Richard Paine, Robert Mariano, Patrick (co-PI) [⬀] Niemczyk, Thomas [⬀] Tierney, David |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Purchase of An X-Ray Diffractometer @ University of New Mexico
With support from the Chemistry Research Instrumentation and Facilities: Departmental Multi-User Instrumentation (CRIF:MU) Program, the Department of Chemistry at the University of New Mexico (UNM) will acquire an X-ray diffractometer with CCD detector and low-temperature system. Some of the research projects that this instrument will support include: preparation of metal complexes and compounds for fixation of carbon dioxide, olefin oligomerization catalysts, and lanthanide- and actinide-ion separations; structural studies in main group and coordination chemistry; and studies of catalysis in pyranopterin molybdenum enzymes and and in using cobalt as a spectroscopic probe of catalytic Zn enzymes. The UNM Chemistry Department will include X-ray crystallography as part of the teaching curriculum in at least two upper-level undergraduate courses and two laboratory classes, as well as at least one graduate-level class. Due to the ethnic diversity of the UNM student population, many chemistry students from traditionally under-represented groups will participate in courses and research projects having X-ray crystallography as a core technique. This is true of the other New Mexico universities that will also make use of the new instrument.
The X-ray diffractometer allows accurate and precise measurements of the full three dimensional structure of a molecule, including bond distances and angles, and it provides accurate information about the spatial arrangement of the molecule relative to the neighboring molecules. Such structural studies have a large impact in a number of areas, especially in the synthesis of important organic and inorganic chemicals and in understanding chemical interactions with biomolecules.
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0.915 |
2009 — 2013 |
Kemp, Richard |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Heteroallenes as Building Blocks For Synthesis and Sequestration @ University of New Mexico
The Inorganic, Bioinorganic, and Organometallic Chemistry Program supports the research of Professor Richard Kemp of the University of New Mexico to investigate the reaction chemistry of CO2 and its heteroallene analogs, COS and CS2, with main group metals. This research project has three parts: to reduce or fix CO2 under mild reaction conditions to produce products (such as CO) that are more amenable to further reaction, to explore the differences in reactivity that are observed during heteroallene reactions with main group compounds, and to investigate the potential catalytic routes to convert CO2 into methylcarbamate or dimethylcarbamate using a nitrogen-ligated, Zn-based cycle. These projects may impact the fixation and sequestration of CO2 on a large scale, reducing CO2 (a greenhouse gas which contributes to global warming) and providing new starting materials for chemical synthesis. Professor Kemp has been successful in attracting and graduating both women and underrepresented minority students. He has developed close interactions with a university in East Africa (Tanzania), bringing promising graduate students from this country to the U.S. for training. It is expected that the majority of these students will return to their former universities as faculty, aiding the economic development of their home institutions and country.
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0.915 |
2010 — 2012 |
Wang, Wei Kemp, Richard Paine, Robert Kirk, Martin [⬀] Mariano, Patrick (co-PI) [⬀] |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
Acquisition of a Low-Field Nmr Spectrometer For Research and Teaching @ University of New Mexico
With this award from the Chemistry Research Instrumentation and Facilities: Departmental Multi-User Instrumentation program (CRIF:MU), Professors Martin L. Kirk, Richard Kemp, Patrick S. Mariano, Robert T. Paine and Wei Wang from the Department of Chemistry and Chemical Biology at the University of New Mexico will acquire a low-field (300 MHz) multinuclear NMR spectrometer. The instrument will be used to support research activities such as: 1) synthetic methodologies that allow for step by-step (atom-by-atom) assembly of new families of main group element ring and polycyclic cage compounds rich in Group 13, 14 and 15 elements; 2) activation and fixing of small molecules such as carbon dioxide, COS, carbon disulfide, and oxygen to produce more valuable products; 3) homogeneous catalytic routes to epoxides and other partially-oxidized organics using late transition metal pincer complexes; 4) characterization of structures and stereochemistry of synthetic intermediates and natural and non-natural products; 5) rational design of Giardia lamblia growth inhibitors as well as study of phosphoproteins; 6) study of donor-bridge-acceptor systems as potential components of molecular wire devices and, 7) synthesis of new inhibitors of the proteins cholesterol esterase, lactate dehydrogenase, NfKB, urokinase, aldose reductase, HIV protease and Abeta aggregates.
Multinuclear NMR spectroscopy is an essential analytical tool in chemistry and biochemistry research. The spectra enable researchers to identify unknown substances and to provide information on the atom arrangement and structures in species ranging from small molecules to large proteins by detecting transitions between energy levels arising from the nuclear spin properties of atoms. This spectrometer will enhance many research activities of investigators and students, many of whom are from underrepresented groups.
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0.915 |
2012 — 2016 |
Kemp, Richard |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
New Earth-Abundant Metal Complexes For Co2 Conversion and Reduction @ University of New Mexico
While many view carbon dioxide (CO2) as a waste gas, there exist efforts in many laboratories to use CO2 as a building block and C1 synthon to produce more complex organic molecules. Most of these ongoing studies utilize rare and expensive late-transition metal complexes as catalysts. In this project funded by the Chemical Synthesis (SYN) section of NSF's Division of Chemistry, Professor Richard Kemp of the University of New Mexico and his students are examining the fundamental reactions of earth-abundant main group and transition metals to reduce CO2 to more valuable, small organic molecules via electrocatalysis. The long-term goal is to eventually use a renewable source of electrons (such as wind or solar derived) to re-energize CO2 back into transportation fuel precursors. If successful, the funded efforts will help lead to a closed carbon loop that allows recycle of CO2 back into transportation fuels for re-use.
While the primary work outputs of this grant will be the trained students and postdoctoral fellows and the published scientific results they generate, the broader impacts of this project extend into environmental chemistry, public policy debate, and the greenhouse gas reduction issue, with long-term implications in the transportation sector as fossil fuels continue to be depleted. UNM is a minority/Hispanic-serving university, and the PI's group has a long-standing history of educating students from under-represented groups, and aiding their entry into STEM careers. This tradition is expected to continue during this current funding period, and the interactions between UNM and overseas partners in third world countries will be further expanded.
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0.915 |