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William F. DeGrado, Ph.D. - US grants

Affiliations: 
1996-2011 University of Pennsylvania, Philadelphia, PA, United States 
 2011- Pharmaceutical Chemistry University of California, San Francisco, San Francisco, CA 
Area:
Organic Chemistry, Chemical Biology, De Novo Protein Design
Website:
http://www.degradolab.org/index.php

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High-probability grants

According to our matching algorithm, William F. DeGrado is the likely recipient of the following grants.
Years Recipients Code Title / Keywords Matching
score
1996 — 2003 Degrado, William F
R01Activity Code Description:
To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies.

De Novo Design of Alpha Helical Bundles

@ University of Pennsylvania

1
1997 — 2000 Degrado, William F
R01Activity Code Description:
To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies.

Bio-Organic Models For Ion Channel Proteins

@ University of Pennsylvania

1
1997 Degrado, William F
S10Activity Code Description:
To make available to institutions with a high concentration of NIH extramural research awards, research instruments which will be used on a shared basis.

Purchase of Analytical Ultracentrifuge

@ University of Pennsylvania

1
1998 — 2007 Degrado, William F
P01Activity Code Description:
For the support of a broadly based, multidisciplinary, often long-term research program which has a specific major objective or a basic theme. A program project generally involves the organized efforts of relatively large groups, members of which are conducting research projects designed to elucidate the various aspects or components of this objective. Each research project is usually under the leadership of an established investigator. The grant can provide support for certain basic resources used by these groups in the program, including clinical components, the sharing of which facilitates the total research effort. A program project is directed toward a range of problems having a central research focus, in contrast to the usually narrower thrust of the traditional research project. Each project supported through this mechanism should contribute or be directly related to the common theme of the total research effort. These scientifically meritorious projects should demonstrate an essential element of unity and interdependence, i.e., a system of research activities and projects directed toward a well-defined research program goal.

Fast Conformational Relaxation in Model Peptides

@ University of Pennsylvania

1
1999 — 2002 Degrado, William
Scialdone, Mark
N/AActivity Code Description:
No activity code was retrieved: click on the grant title for more information

Protein Mimetics Based On Beta Amino Acids

@ University of Pennsylvania

0.915
2001 — 2016 Degrado, William F
R01Activity Code Description:
To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies.

Structure of M2 Proton Channel From Influenza a Virus

@ University of Pennsylvania

1
2001 — 2005 Degrado, William
Percec, Virgil [⬀]
Heiney, Paul (co-PI) [⬀]
Winey, Karen (co-PI) [⬀]
Kamien, Randall (co-PI) [⬀]
N/AActivity Code Description:
No activity code was retrieved: click on the grant title for more information

Nse/Nirt: Single Molecule Functional Nanostructures

@ University of Pennsylvania

0.915
2002 — 2005 Degrado, William F
R01Activity Code Description:
To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies.

Proteomics to Biomimetic Polymers: Engineering Principle

@ University of Pennsylvania

1
2002 — 2007 Goulian, Mark (co-PI) [⬀]
Saven, Jeffery (co-PI) [⬀]
Degrado, William
Boder, Eric [⬀]
N/AActivity Code Description:
No activity code was retrieved: click on the grant title for more information

Nirt: Combinatorial Engineering of Nanomachines: Building Novel Membrane Proteins Via De Novo Design and Directed Evolution

@ University of Pennsylvania

0.915
2003 — 2008 Degrado, William
Bonnell, Dawn [⬀]
Johnson, Alan
Evoy, Stephane (co-PI) [⬀]
N/AActivity Code Description:
No activity code was retrieved: click on the grant title for more information

Nirt: Complex Nanostructures of Dissimilar Elements: Synthesis, Assembly & Proximal Electrical and Optical Interactions

@ University of Pennsylvania

0.915
2004 — 2016 Degrado, William F
R01Activity Code Description:
To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies.
R37Activity Code Description:
To provide long-term grant support to investigators whose research competence and productivity are distinctly superior and who are highly likely to continue to perform in an outstanding manner. Investigators may not apply for a MERIT award. Program staff and/or members of the cognizant National Advisory Council/Board will identify candidates for the MERIT award during the course of review of competing research grant applications prepared and submitted in accordance with regular PHS requirements.

De Novo Design of Alpha-Helical Bundles

@ University of Pennsylvania

1
2004 — 2007 Degrado, William F
P41Activity Code Description:
Undocumented code - click on the grant title for more information.

Time Resolved Ir Studies of Helix Coil Transition in Small Peptides

@ University of Pennsylvania

1
2004 — 2006 Degrado, William F
P41Activity Code Description:
Undocumented code - click on the grant title for more information.

Dynamics &Structure of Individual Calmodulin Peptide Complex

@ University of Pennsylvania

1
2004 — 2006 Degrado, William F
P41Activity Code Description:
Undocumented code - click on the grant title for more information.

2d Ir of Isotope Heptaproline Peptide

@ University of Pennsylvania

1
2005 — 2006 Degrado, William F
P41Activity Code Description:
Undocumented code - click on the grant title for more information.

Structure Prediction of Membrane Proteins

@ Mellon Pitts Corporation (Mpc Corp)

0.939
2005 — 2007 Degrado, William F
P41Activity Code Description:
Undocumented code - click on the grant title for more information.

Using Nitrile-Derivatized Amino Acids as Infrared Probes of Local Environment

@ University of Pennsylvania

1
2005 — 2006 Degrado, William F
P41Activity Code Description:
Undocumented code - click on the grant title for more information.

2d Ir of Membrane Proteins

@ University of Pennsylvania

1
2005 — 2006 Degrado, William F
P41Activity Code Description:
Undocumented code - click on the grant title for more information.

Association and Dissociation Dynamics of Transmembrane Helices

@ University of Pennsylvania

1
2006 — 2009 Degrado, William F
R01Activity Code Description:
To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies.

Bioorganic Models For Transmembrane Proteins

@ University of Pennsylvania

1
2007 — 2008 Degrado, William F
P41Activity Code Description:
Undocumented code - click on the grant title for more information.

Design of Biologically Active Novel Proteins

@ Carnegie-Mellon University

0.939
2007 Degrado, William F
P41Activity Code Description:
Undocumented code - click on the grant title for more information.

2d Ir of Trans-Membrane Structures

@ University of Pennsylvania

1
2008 — 2012 Degrado, William F
U01Activity Code Description:
To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies.

Development of Drugs That Target the M2 Proton Channel From the Influenza a Virus

@ University of Pennsylvania

1
2008 — 2013 Degrado, William F
R01Activity Code Description:
To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies.
R56Activity Code Description:
To provide limited interim research support based on the merit of a pending R01 application while applicant gathers additional data to revise a new or competing renewal application. This grant will underwrite highly meritorious applications that if given the opportunity to revise their application could meet IC recommended standards and would be missed opportunities if not funded. Interim funded ends when the applicant succeeds in obtaining an R01 or other competing award built on the R56 grant. These awards are not renewable.

Design and Mechanistic Studies of Mimics of Antimicrobial Peptides

@ University of California, San Francisco

1
2008 — 2011 Degrado, William F
P41Activity Code Description:
Undocumented code - click on the grant title for more information.

2d Ir of Trans-Membrane Helix Structures

@ University of Pennsylvania

1
2008 — 2009 Degrado, William F
P41Activity Code Description:
Undocumented code - click on the grant title for more information.

Time Resolved Studies of Helix Coil Transition in Small Peptides

@ University of Pennsylvania

1
2009 Degrado, William F
P41Activity Code Description:
Undocumented code - click on the grant title for more information.

Probing the Proton Gating Dynamics of the Influenza Virus M2 Channel Using Fcs

@ University of Pennsylvania

1
2010 — 2011 Degrado, William F
P41Activity Code Description:
Undocumented code - click on the grant title for more information.

2d Ir Spectroscopy of Collagen Domain Structures

@ University of Pennsylvania

1
2011 Degrado, William F
P41Activity Code Description:
Undocumented code - click on the grant title for more information.

Develpment of Drugs That Target the M2 Proton Channel

@ University of Wisconsin-Madison

0.958
2011 Degrado, William F
P41Activity Code Description:
Undocumented code - click on the grant title for more information.

Transmembrane Domain of Influenza a M2 Proton Channel

@ Cornell University

0.957
2012 — 2015 Degrado, William F
Lu, Shan (co-PI) [⬀]
Nieva, Jose
Scott, Jamie Kathleen
R01Activity Code Description:
To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies.

Vaccines That Replicate the Neutralization-Competent Structure of the Gp41 Mper

@ Simon Fraser University

0.942
2014 — 2021 Degrado, William
N/AActivity Code Description:
No activity code was retrieved: click on the grant title for more information

Collaborative Research: De Novo Protein Constructs For Photosynthetic Energy Transduction

@ University of California-San Francisco

0.915
2014 — 2018 Degrado, William F
Sheppard, Dean [⬀]
UH2Activity Code Description:
To support the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.)
UH3Activity Code Description:
The UH3 award is to provide a second phase for the support for innovative exploratory and development research activities initiated under the UH2 mechanism. Although only UH2 awardees are generally eligible to apply for UH3 support, specific program initiatives may establish eligibility criteria under which applications could be accepted from applicants demonstrating progress equivalent to that expected under UH2.

Treatment of Pulmonary Fibrosis With Inhibitors of Integrin Alphavbeta1.

@ University of California, San Francisco

1
2015 — 2019 Degrado, William F
P01Activity Code Description:
For the support of a broadly based, multidisciplinary, often long-term research program which has a specific major objective or a basic theme. A program project generally involves the organized efforts of relatively large groups, members of which are conducting research projects designed to elucidate the various aspects or components of this objective. Each research project is usually under the leadership of an established investigator. The grant can provide support for certain basic resources used by these groups in the program, including clinical components, the sharing of which facilitates the total research effort. A program project is directed toward a range of problems having a central research focus, in contrast to the usually narrower thrust of the traditional research project. Each project supported through this mechanism should contribute or be directly related to the common theme of the total research effort. These scientifically meritorious projects should demonstrate an essential element of unity and interdependence, i.e., a system of research activities and projects directed toward a well-defined research program goal.

Project 3: Assembly and Structures of Abeta Peptides.

@ University of California, San Francisco

1
2017 — 2021 Degrado, William F
R35Activity Code Description:
To provide long term support to an experienced investigator with an outstanding record of research productivity. This support is intended to encourage investigators to embark on long-term projects of unusual potential.

Deciphering the Relationship Between Structure, Dynamics and Function in Helical Bundle Proteins

@ University of California, San Francisco

1
2020 Degrado, William F
P01Activity Code Description:
For the support of a broadly based, multidisciplinary, often long-term research program which has a specific major objective or a basic theme. A program project generally involves the organized efforts of relatively large groups, members of which are conducting research projects designed to elucidate the various aspects or components of this objective. Each research project is usually under the leadership of an established investigator. The grant can provide support for certain basic resources used by these groups in the program, including clinical components, the sharing of which facilitates the total research effort. A program project is directed toward a range of problems having a central research focus, in contrast to the usually narrower thrust of the traditional research project. Each project supported through this mechanism should contribute or be directly related to the common theme of the total research effort. These scientifically meritorious projects should demonstrate an essential element of unity and interdependence, i.e., a system of research activities and projects directed toward a well-defined research program goal.

Project 2: Conformation and Propagation of Misfolded Forms of Tau and Abeta

@ University of California, San Francisco

1
2021 — 2024 Degrado, William
N/AActivity Code Description:
No activity code was retrieved: click on the grant title for more information

Collaborative Research: De Novo Protein Constructs For Photosynthetic Energy Transduction

@ University of California-San Francisco

0.915