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Chun Pong Tam

Affiliations: 
2011- Chemistry Harvard University, Cambridge, MA, United States 
Area:
Chemistry
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"Chun Pong Tam"
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Jack W. Szostak grad student 2013-2018 Harvard Medical School

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Albert C. Fahrenbach collaborator 2013- Harvard Medical School
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Walton T, Zhang W, Li L, et al. (2019) The mechanism of nonenzymatic template copying with imidazole-activated nucleotides. Angewandte Chemie (International Ed. in English)
Zhang W, Tam CP, Zhou L, et al. (2018) A structural rationale for the enhanced catalysis of nonenzymatic RNA primer extension by a downstream oligonucleotide. Journal of the American Chemical Society
Tam CP, Zhou L, Fahrenbach AC, et al. (2017) Synthesis of a nonhydrolyzable nucleotide phosphoroimidazolide analogue that catalyzes nonenzymatic RNA primer extension. Journal of the American Chemical Society
Giurgiu C, Li L, O'Flaherty DK, et al. (2017) A Mechanistic Explanation for the Regioselectivity of Nonenzymatic RNA Primer Extension. Journal of the American Chemical Society
Zhang W, Tam CP, Walton T, et al. (2017) Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex. Proceedings of the National Academy of Sciences of the United States of America
Fahrenbach AC, Giurgiu C, Tam CP, et al. (2017) Common and Potentially Prebiotic Origin for Precursors of Nucleotide Synthesis and Activation. Journal of the American Chemical Society
Li L, Prywes N, Tam CP, et al. (2017) Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides. Journal of the American Chemical Society
Tam CP, Fahrenbach AC, Björkbom A, et al. (2017) Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer-Template Complexes. Journal of the American Chemical Society
Zhang W, Tam CP, Wang J, et al. (2016) Unusual Base-Pairing Interactions in Monomer-Template Complexes. Acs Central Science. 2: 916-926
Tan L, Gurbani D, Weisberg EL, et al. (2016) Structure-guided development of covalent TAK1 inhibitors. Bioorganic & Medicinal Chemistry
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