Michael L. Schulte
Affiliations: | 2009-2013 | Chemistry | Vanderbilt University, Nashville, TN |
Area:
PET Imaging, Drug Discovery, Organic SynthesisWebsite:
http://www.vuiis.vanderbilt.edu/bio/michael.l.schulteGoogle:
"Michael Schulte"Mean distance: 8.52 | S | N | B | C | P |
Parents
Sign in to add mentor| Craig W. Lindsley | grad student | 2009-2013 | Vanderbilt | |
| (Application of organocatalysis to the synthesis of pharmaceutically relevant scaffolds: Chiral aziridines and beta-fluoroamines; total synthesis of stemaphylline; and discovery of selective PAR4 antagonists.) | ||||
| H. Charles Manning | post-doc | 2013-2015 | Vanderbilt University Medical School | |
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Publications
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| Yamada Y, Gilliland K, Xiang Z, et al. (2021) Positive allosteric modulators (PAMs) of the group II metabotropic glutamate receptors: Design, synthesis, and evaluation as ex-vivo tool compounds. Bioorganic & Medicinal Chemistry Letters. 128342 |
| Cohen AS, Geng L, Zhao P, et al. (2020) Combined blockade of EGFR and glutamine metabolism in preclinical models of colorectal cancer. Translational Oncology. 13: 100828 |
| Yamada Y, Yohn SE, Gilliland K, et al. (2019) Further exploration of an N-aryl phenoxyethoxy pyridinone-based series of mGlu NAMs: Challenging SAR, enantiospecific activity and in vivo efficacy. Bioorganic & Medicinal Chemistry Letters |
| Rosenberg AJ, Nickels ML, Schulte ML, et al. (2018) Automated radiosynthesis of 5-[C]l-glutamine, an important tracer for glutamine utilization. Nuclear Medicine and Biology. 67: 10-14 |
| Zhang Q, Jeppesen DK, Higginbotham JN, et al. (2018) Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells. Cellular and Molecular Gastroenterology and Hepatology. 5: 627-629.e6 |
| Schulte ML, Fu A, Zhao P, et al. (2018) Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models. Nature Medicine |
| Li J, Smith JA, Dawson ES, et al. (2017) An Optimized Translocator Protein Ligand for Optical Molecular Imaging and Screening. Bioconjugate Chemistry |
| Schulte ML, Hight MR, Ayers GD, et al. (2016) Non-Invasive Glutamine PET Reflects Pharmacological Inhibition of BRAF(V600E) In Vivo. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging |
| Li J, Schulte ML, Nickels ML, et al. (2016) New structure-activity relationships of N-acetamide substituted pyrazolopyrimidines as pharmacological ligands of TSPO. Bioorganic & Medicinal Chemistry Letters |
| Schulte ML, Khodadadi AB, Cuthbertson ML, et al. (2015) 2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport. Bioorganic & Medicinal Chemistry Letters |